GCF_002206385.2_ASM220638v2_genomic - 8 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_NJFR02000001 (original name was: NZ_NJFR02000001.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	thiopeptide	679,944	706,378
Region 1.2	terpene	1,361,714	1,382,805
Region 1.3	redox-cofactor	1,392,825	1,414,990	lankacidin C	NRP + Polyketide	13%
Region 1.4	NRPS	2,451,922	2,495,866	turnerbactin	NRP	38%
Region 1.5	hserlactone	4,102,818	4,121,067
Region 1.6	hserlactone	4,122,457	4,142,999
Region 1.7	betalactone	4,732,746	4,758,406
Region 1.8	arylpolyene,siderophore	4,888,590	4,937,020	APE Ec	Other	84%

Region	Type	From	To	Most similar known cluster	Similarity
Region 1.1	thiopeptide	679,944	706,378
Region 1.2	terpene	1,361,714	1,382,805
Region 1.3	redox-cofactor	1,392,825	1,414,990	lankacidin C	NRP + Polyketide	13%
Region 1.4	NRPS	2,451,922	2,495,866	turnerbactin	NRP	38%
Region 1.5	hserlactone	4,102,818	4,121,067
Region 1.6	hserlactone	4,122,457	4,142,999
Region 1.7	betalactone	4,732,746	4,758,406
Region 1.8	arylpolyene,siderophore	4,888,590	4,937,020	APE Ec	Other	84%

No secondary metabolite regions were found in these records:: NZ_NJFR02000002 (original name was: NZ_NJFR02000002.1); NZ_NJFR02000003 (original name was: NZ_NJFR02000003.1); NZ_NJFR02000004 (original name was: NZ_NJFR02000004.1); NZ_NJFR02000005 (original name was: NZ_NJFR02000005.1); NZ_NJFR02000006 (original name was: NZ_NJFR02000006.1)

Compact view

c00001_NZ_NJFR.. - Region 1 - thiopeptide

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Location: 679,944 - 706,378 nt. (total: 26,435 nt) Show pHMM detection rules used

thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

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Thiopeptides

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	thiopeptide	Similarity score	Type	Compound(s)	Organism
BGC0001285.1		0.12	Other (Fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0001441.1		0.09	Other	belactosin A, belactosin C	Streptomyces sp.

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0001285.1		0.39	Other (Fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0001441.1		0.33	Other	belactosin A, belactosin C	Streptomyces sp.

Similar known gene clusters

No matches found.

Thiopeptide predictions

No core peptides found.

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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Thiopeptides

Core peptide predictions

No core peptides found.

c00001_NZ_NJFR.. - Region 2 - terpene

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Location: 1,361,714 - 1,382,805 nt. (total: 21,092 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

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Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000859.1	0.26	Other	ectoine	Methylomicrobium alcaliphilum
BGC0000854.1	0.26	Other	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000857.1	0.26	Other	ectoine	Methylophaga alcalica
BGC0000855.1	0.25	Other	ectoine	Methylomicrobium kenyense
BGC0000852.1	0.25	Other	ectoine	Sporosarcina pasteurii
BGC0000858.1	0.25	Other	ectoine	Methylobacter marinus
BGC0000853.1	0.25	Other	ectoine	Streptomyces anulatus
BGC0000856.1	0.25	Other	ectoine	Methylophaga thalassica
BGC0000860.1	0.25	Other	ectoine	Methylarcula marina
BGC0000664.1	0.21	Terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000859.1	0.59	Other	ectoine	Methylomicrobium alcaliphilum
BGC0000854.1	0.59	Other	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000857.1	0.59	Other	ectoine	Methylophaga alcalica
BGC0000855.1	0.59	Other	ectoine	Methylomicrobium kenyense
BGC0000852.1	0.59	Other	ectoine	Sporosarcina pasteurii
BGC0000858.1	0.59	Other	ectoine	Methylobacter marinus
BGC0000853.1	0.59	Other	ectoine	Streptomyces anulatus
BGC0000856.1	0.58	Other	ectoine	Methylophaga thalassica
BGC0000860.1	0.58	Other	ectoine	Methylarcula marina
BGC0000664.1	0.53	Terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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c00001_NZ_NJFR.. - Region 3 - redox-cofactor

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Location: 1,392,825 - 1,414,990 nt. (total: 22,166 nt) Show pHMM detection rules used

redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

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Pfam domains

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000905.1	0.13	Other	heme D1	Heliobacillus mobilis
BGC0000320.1	0.12	NRP	cereulide	Bacillus cereus
BGC0000297.1	0.11	NRP, Polyketide, Saccharide	aeruginoside 126B, aeruginoside 126A	Planktothrix agardhii NIVA-CYA 126
BGC0001365.1	0.09	NRP	clapurines	Claviceps purpurea 20.1
BGC0000321.1	0.09	NRP	chaetocin	Collariella virescens
BGC0001100.1	0.09	NRP, Polyketide	lankacidin C	Streptomyces rochei
BGC0001212.1	0.08	NRP, Polyketide	nannocystin a	Nannocystis sp. MB1016
BGC0000292.1	0.08	NRP	acetylaranotin	Aspergillus terreus NIH2624
BGC0001656.1	0.08	Polyketide	luminaolide	Planktothrix paucivesiculata PCC 9631
BGC0000361.1	0.08	NRP	gliotoxin, bisdethiobis(methylthio)gliotoxin	Aspergillus fumigatus Af293

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000905.1	0.41	Other	heme D1	Heliobacillus mobilis
BGC0000320.1	0.39	NRP	cereulide	Bacillus cereus
BGC0000297.1	0.38	NRP, Polyketide, Saccharide	aeruginoside 126B, aeruginoside 126A	Planktothrix agardhii NIVA-CYA 126
BGC0001365.1	0.34	NRP	clapurines	Claviceps purpurea 20.1
BGC0000321.1	0.33	NRP	chaetocin	Collariella virescens
BGC0001100.1	0.33	NRP, Polyketide	lankacidin C	Streptomyces rochei
BGC0001212.1	0.32	NRP, Polyketide	nannocystin a	Nannocystis sp. MB1016
BGC0000292.1	0.32	NRP	acetylaranotin	Aspergillus terreus NIH2624
BGC0001656.1	0.30	Polyketide	luminaolide	Planktothrix paucivesiculata PCC 9631
BGC0000361.1	0.30	NRP	gliotoxin, bisdethiobis(methylthio)gliotoxin	Aspergillus fumigatus Af293

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Detailed TIGRFAM domain annotation

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c00001_NZ_NJFR.. - Region 4 - NRPS

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Location: 2,451,922 - 2,495,866 nt. (total: 43,945 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

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NRPS/PKS domains

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NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.1	0.34	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001615.1	0.32	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0000401.1	0.29	NRP	paenibactin	Paenibacillus elgii B69
BGC0001132.1	0.25	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001302.1	0.25	Other	lomofungin	Streptomyces lomondensis
BGC0000454.1	0.25	NRP	vanchrobactin	Vibrio anguillarum RV22
BGC0001833.1	0.25	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.1	0.24	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001131.1	0.24	NRP	ambactin	Xenorhabdus miraniensis
BGC0001844.1	0.24	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.1	0.67	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001615.1	0.66	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0000401.1	0.62	NRP	paenibactin	Paenibacillus elgii B69
BGC0001132.1	0.58	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001302.1	0.58	Other	lomofungin	Streptomyces lomondensis
BGC0000454.1	0.58	NRP	vanchrobactin	Vibrio anguillarum RV22
BGC0001833.1	0.58	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.1	0.58	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001131.1	0.58	NRP	ambactin	Xenorhabdus miraniensis
BGC0001844.1	0.57	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454

Similar known gene clusters

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Detailed TIGRFAM domain annotation

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 4, location 2451921 - 2495866:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_2338

Search NORINE for peptide: strict or relaxed

AMP-binding (33..438): dhb

NRPSPredictor2: dhb

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: PMPAQGVVNK
Nearest Stachelhaus code:: dhb
Stachelhaus code match:: 100% (strong)

ctg1_2345

Search NORINE for peptide: strict or relaxed

AMP-binding (475..877): ser

NRPSPredictor2: ser

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLVDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

c00001_NZ_NJFR.. - Region 5 - hserlactone

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Location: 4,102,818 - 4,121,067 nt. (total: 18,250 nt) Show pHMM detection rules used

hserlactone: Autoind_synth

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core biosynthetic genes

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KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001120.1	0.18	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0001475.1	0.17	Polyketide	aspterric acid	Aspergillus terreus NIH2624
BGC0001387.1	0.16	Other	nucleocidin	Streptomyces calvus
BGC0001928.1	0.15	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000294.1	0.15	NRP	acinetobactin	Acinetobacter baumannii
BGC0000243.1	0.14	Polyketide	macrotetrolide	Streptomyces griseus subsp. griseus
BGC0001289.1	0.14	RiPP	penisin	Paenibacillus ehimensis
BGC0001221.1	0.13	Other (Phenazine)	marinophenazine A, phenaziterpene A	Streptomyces sp. CNQ-509
BGC0001047.1	0.08	NRP, Polyketide	syringolin A	Pseudomonas syringae
BGC0000145.1	0.08	Polyketide	salinosporamide A	Salinispora tropica

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001120.1	0.49	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0001475.1	0.47	Polyketide	aspterric acid	Aspergillus terreus NIH2624
BGC0001387.1	0.47	Other	nucleocidin	Streptomyces calvus
BGC0001928.1	0.45	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000294.1	0.45	NRP	acinetobactin	Acinetobacter baumannii
BGC0000243.1	0.44	Polyketide	macrotetrolide	Streptomyces griseus subsp. griseus
BGC0001289.1	0.43	RiPP	penisin	Paenibacillus ehimensis
BGC0001221.1	0.42	Other (Phenazine)	marinophenazine A, phenaziterpene A	Streptomyces sp. CNQ-509
BGC0001047.1	0.31	NRP, Polyketide	syringolin A	Pseudomonas syringae
BGC0000145.1	0.30	Polyketide	salinosporamide A	Salinispora tropica

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

Selected features only

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c00001_NZ_NJFR.. - Region 6 - hserlactone

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Location: 4,122,457 - 4,142,999 nt. (total: 20,543 nt) Show pHMM detection rules used

hserlactone: Autoind_synth

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002007.1	0.09	Terpene	atolypene A, atolypene B	Amycolatopsis tolypomycina
BGC0001469.1	0.08	NRP	marthiapeptide A	Brevibacillus sp. Leaf182
BGC0001437.1	0.07	NRP	obafluorin	Pseudomonas fluorescens
BGC0001710.1	0.07	NRP	obafluorin	Pseudomonas fluorescens
BGC0001480.1	0.06	Other	tundrenone	Methylobacter tundripaludum 21/22
BGC0000080.1	0.04	Polyketide	jerangolid A, jerangolid D	Sorangium cellulosum
BGC0000014.1	0.04	Polyketide	ambruticin	Sorangium cellulosum
BGC0000182.1	0.03	Polyketide	pseudomonic acid A	Pseudomonas fluorescens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002007.1	0.33	Terpene	atolypene A, atolypene B	Amycolatopsis tolypomycina
BGC0001469.1	0.30	NRP	marthiapeptide A	Brevibacillus sp. Leaf182
BGC0001437.1	0.28	NRP	obafluorin	Pseudomonas fluorescens
BGC0001710.1	0.28	NRP	obafluorin	Pseudomonas fluorescens
BGC0001480.1	0.26	Other	tundrenone	Methylobacter tundripaludum 21/22
BGC0000080.1	0.20	Polyketide	jerangolid A, jerangolid D	Sorangium cellulosum
BGC0000014.1	0.18	Polyketide	ambruticin	Sorangium cellulosum
BGC0000182.1	0.17	Polyketide	pseudomonic acid A	Pseudomonas fluorescens

Similar known gene clusters

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Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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c00001_NZ_NJFR.. - Region 7 - betalactone

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Location: 4,732,746 - 4,758,406 nt. (total: 25,661 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

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Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001859.1	0.20	Other (Phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000904.1	0.16	Other	FR-900098	Streptomyces rubellomurinus
BGC0001441.1	0.14	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0001758.1	0.14	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001132.1	0.14	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000597.1	0.13	RiPP	SWA-2138	Streptomyces sp. e14
BGC0000207.1	0.13	Polyketide	chartreusin	Streptomyces chartreusis
BGC0000595.1	0.13	RiPP	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000596.1	0.13	RiPP	SLI-2138	Streptomyces lividans TK24
BGC0000805.1	0.13	Saccharide	moenomycin	Streptomyces viridosporus ATCC 14672

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001859.1	0.52	Other (Phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000904.1	0.46	Other	FR-900098	Streptomyces rubellomurinus
BGC0001441.1	0.44	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0001758.1	0.43	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001132.1	0.43	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000597.1	0.41	RiPP	SWA-2138	Streptomyces sp. e14
BGC0000207.1	0.41	Polyketide	chartreusin	Streptomyces chartreusis
BGC0000595.1	0.41	RiPP	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000596.1	0.41	RiPP	SLI-2138	Streptomyces lividans TK24
BGC0000805.1	0.41	Saccharide	moenomycin	Streptomyces viridosporus ATCC 14672

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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c00001_NZ_NJFR.. - Region 8 - arylpolyene,siderophore

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Location: 4,888,590 - 4,937,020 nt. (total: 48,431 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)
siderophore: IucA_IucC

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core biosynthetic genes

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MIBiG comparison

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Pfam domains

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001499.1	1.05	Other	aerobactin	Pantoea ananatis
BGC0001498.1	0.75	Other	aerobactin	Xenorhabdus szentirmaii DSM 16338
BGC0001478.1	0.65	Other	desferrioxamine E	Streptomyces sp. ID38640
BGC0001572.1	0.58	Other	desferrioxamine E	Pantoea agglomerans
BGC0001713.1	0.57	Other	ochrobactin	Ochrobactrum anthropi
BGC0000939.1	0.54	Other	aerobactin	Grimontia hollisae
BGC0001555.1	0.47	RiPP	colicin V	Escherichia coli chi7122
BGC0000940.1	0.45	Other	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0002008.1	0.45	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000941.1	0.41	Other	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001499.1	0.82	Other	aerobactin	Pantoea ananatis
BGC0002008.1	0.75	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0001498.1	0.73	Other	aerobactin	Xenorhabdus szentirmaii DSM 16338
BGC0000836.1	0.70	Other	APE Ec	Escherichia coli CFT073
BGC0001478.1	0.66	Other	desferrioxamine E	Streptomyces sp. ID38640
BGC0000837.1	0.65	Other	APE Vf	Aliivibrio fischeri ES114
BGC0001572.1	0.63	Other	desferrioxamine E	Pantoea agglomerans
BGC0001713.1	0.62	Other	ochrobactin	Ochrobactrum anthropi
BGC0000939.1	0.59	Other	aerobactin	Grimontia hollisae
BGC0001723.1	0.58	Polyketide	oviedomycin	Streptomyces antibioticus

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Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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