GCF_001523705.1_ASM152370v1_genomic - 12 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_LOWL01000017 (original name was: NZ_LOWL01000017.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 16.1	terpene	165,549	186,616

NZ_LOWL01000022 (original name was: NZ_LOWL01000022.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 20.1	hserlactone	44,400	65,008

NZ_LOWL01000024 (original name was: NZ_LOWL01000024.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 21.1	arylpolyene	83,708	128,571	APE Vf	Other	35%
Region 21.2	NRPS-like,NRPS,T1PKS	196,487	280,952	occidiofungin A	NRP + Polyketide	94%

NZ_LOWL01000025 (original name was: NZ_LOWL01000025.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 22.1	redox-cofactor	3,583	25,706	lankacidin C	NRP + Polyketide	13%

NZ_LOWL01000030 (original name was: NZ_LOWL01000030.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 27.1	phosphonate	96,040	137,725	phosphinothricintripeptide	NRP	6%

NZ_LOWL01000036 (original name was: NZ_LOWL01000036.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 32.1	arylpolyene	150,436	175,279	APE Vf	Other	10%

NZ_LOWL01000037 (original name was: NZ_LOWL01000037.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 33.1	terpene	153,523	177,621

NZ_LOWL01000042 (original name was: NZ_LOWL01000042.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 38.1	RiPP-like	51,071	61,886

NZ_LOWL01000046 (original name was: NZ_LOWL01000046.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 42.1	hserlactone	94,196	114,855	cepacin A	Polyketide	62%

NZ_LOWL01000056 (original name was: NZ_LOWL01000056.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 49.1	NRPS	34,446	89,196	ornibactin	NRP	93%

NZ_LOWL01000059 (original name was: NZ_LOWL01000059.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 52.1	terpene	95,116	116,021

Region	Type	From	To	Most similar known cluster	Similarity
Region 16.1	terpene	165,549	186,616
Region 20.1	hserlactone	44,400	65,008
Region 21.1	arylpolyene	83,708	128,571	APE Vf	Other	35%
Region 21.2	NRPS-like,NRPS,T1PKS	196,487	280,952	occidiofungin A	NRP + Polyketide	94%
Region 22.1	redox-cofactor	3,583	25,706	lankacidin C	NRP + Polyketide	13%
Region 27.1	phosphonate	96,040	137,725	phosphinothricintripeptide	NRP	6%
Region 32.1	arylpolyene	150,436	175,279	APE Vf	Other	10%
Region 33.1	terpene	153,523	177,621
Region 38.1	RiPP-like	51,071	61,886
Region 42.1	hserlactone	94,196	114,855	cepacin A	Polyketide	62%
Region 49.1	NRPS	34,446	89,196	ornibactin	NRP	93%
Region 52.1	terpene	95,116	116,021

No secondary metabolite regions were found in these records:: NZ_LOWL01000001 (original name was: NZ_LOWL01000001.1); NZ_LOWL01000002 (original name was: NZ_LOWL01000002.1); NZ_LOWL01000003 (original name was: NZ_LOWL01000003.1); NZ_LOWL01000004 (original name was: NZ_LOWL01000004.1); NZ_LOWL01000005 (original name was: NZ_LOWL01000005.1); NZ_LOWL01000007 (original name was: NZ_LOWL01000007.1); NZ_LOWL01000008 (original name was: NZ_LOWL01000008.1); NZ_LOWL01000009 (original name was: NZ_LOWL01000009.1); NZ_LOWL01000010 (original name was: NZ_LOWL01000010.1); NZ_LOWL01000011 (original name was: NZ_LOWL01000011.1); NZ_LOWL01000012 (original name was: NZ_LOWL01000012.1); NZ_LOWL01000013 (original name was: NZ_LOWL01000013.1); NZ_LOWL01000014 (original name was: NZ_LOWL01000014.1); NZ_LOWL01000015 (original name was: NZ_LOWL01000015.1); NZ_LOWL01000016 (original name was: NZ_LOWL01000016.1); NZ_LOWL01000018 (original name was: NZ_LOWL01000018.1); NZ_LOWL01000020 (original name was: NZ_LOWL01000020.1); NZ_LOWL01000021 (original name was: NZ_LOWL01000021.1); NZ_LOWL01000026 (original name was: NZ_LOWL01000026.1); NZ_LOWL01000027 (original name was: NZ_LOWL01000027.1); NZ_LOWL01000028 (original name was: NZ_LOWL01000028.1); NZ_LOWL01000029 (original name was: NZ_LOWL01000029.1); NZ_LOWL01000031 (original name was: NZ_LOWL01000031.1); NZ_LOWL01000032 (original name was: NZ_LOWL01000032.1); NZ_LOWL01000034 (original name was: NZ_LOWL01000034.1); NZ_LOWL01000035 (original name was: NZ_LOWL01000035.1); NZ_LOWL01000038 (original name was: NZ_LOWL01000038.1); NZ_LOWL01000039 (original name was: NZ_LOWL01000039.1); NZ_LOWL01000040 (original name was: NZ_LOWL01000040.1); NZ_LOWL01000041 (original name was: NZ_LOWL01000041.1); NZ_LOWL01000043 (original name was: NZ_LOWL01000043.1); NZ_LOWL01000044 (original name was: NZ_LOWL01000044.1); NZ_LOWL01000045 (original name was: NZ_LOWL01000045.1); NZ_LOWL01000047 (original name was: NZ_LOWL01000047.1); NZ_LOWL01000048 (original name was: NZ_LOWL01000048.1); NZ_LOWL01000051 (original name was: NZ_LOWL01000051.1); NZ_LOWL01000052 (original name was: NZ_LOWL01000052.1); NZ_LOWL01000053 (original name was: NZ_LOWL01000053.1); NZ_LOWL01000054 (original name was: NZ_LOWL01000054.1); NZ_LOWL01000057 (original name was: NZ_LOWL01000057.1); NZ_LOWL01000058 (original name was: NZ_LOWL01000058.1); NZ_LOWL01000060 (original name was: NZ_LOWL01000060.1); NZ_LOWL01000061 (original name was: NZ_LOWL01000061.1); NZ_LOWL01000063 (original name was: NZ_LOWL01000063.1); NZ_LOWL01000064 (original name was: NZ_LOWL01000064.1)

Compact view

c00016_NZ_LOWL.. - Region 1 - terpene

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Location: 165,549 - 186,616 nt. (total: 21,068 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000648.1	0.34	Terpene	carotenoid	Myxococcus xanthus
BGC0000647.1	0.31	Terpene	carotenoid	Rhodobacter sphaeroides
BGC0000888.1	0.22	Other	bacilysin	Bacillus sp. CS93
BGC0001184.1	0.22	Other	bacilysin	Bacillus velezensis FZB42
BGC0000643.1	0.21	Terpene	carotenoid	Brevundimonas vesicularis
BGC0001928.1	0.19	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0001444.1	0.19	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.19	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0000630.1	0.19	Terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000886.1	0.19	Other	allylmalonyl-CoA	Streptomyces tsukubensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000648.1	0.67	Terpene	carotenoid	Myxococcus xanthus
BGC0000647.1	0.65	Terpene	carotenoid	Rhodobacter sphaeroides
BGC0000888.1	0.54	Other	bacilysin	Bacillus sp. CS93
BGC0001184.1	0.54	Other	bacilysin	Bacillus velezensis FZB42
BGC0000643.1	0.54	Terpene	carotenoid	Brevundimonas vesicularis
BGC0001928.1	0.51	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0001444.1	0.51	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.51	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0000630.1	0.51	Terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000886.1	0.51	Other	allylmalonyl-CoA	Streptomyces tsukubensis

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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c00020_NZ_LOWL.. - Region 1 - hserlactone

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Location: 44,400 - 65,008 nt. (total: 20,609 nt) Show pHMM detection rules used

hserlactone: Autoind_synth

Legend:

core biosynthetic genes

additional biosynthetic genes

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regulatory genes

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000785.1	0.20	Saccharide	O-antigen	Burkholderia mallei
BGC0001973.1	0.19	Other	fervenulin	Streptomyces hiroshimensis
BGC0001972.1	0.19	Other	toxoflavin, fervenulin	Streptomyces hiroshimensis
BGC0000929.1	0.18	Other	xanthothricin	Burkholderia glumae
BGC0001959.1	0.18	Other	taylorflavin A, taylorflavin B	Streptomyces hiroshimensis
BGC0000772.1	0.17	Saccharide	lipopolysaccharide	Brucella melitensis
BGC0001897.1	0.12	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0001671.1	0.08	NRP	monobactam	Agrobacterium tumefaciens
BGC0001480.1	0.07	Other	tundrenone	Methylobacter tundripaludum 21/22
BGC0001437.1	0.06	NRP	obafluorin	Pseudomonas fluorescens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000785.1	0.52	Saccharide	O-antigen	Burkholderia mallei
BGC0001973.1	0.51	Other	fervenulin	Streptomyces hiroshimensis
BGC0001972.1	0.51	Other	toxoflavin, fervenulin	Streptomyces hiroshimensis
BGC0000929.1	0.50	Other	xanthothricin	Burkholderia glumae
BGC0001959.1	0.50	Other	taylorflavin A, taylorflavin B	Streptomyces hiroshimensis
BGC0000772.1	0.49	Saccharide	lipopolysaccharide	Brucella melitensis
BGC0001897.1	0.40	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0001671.1	0.30	NRP	monobactam	Agrobacterium tumefaciens
BGC0001480.1	0.27	Other	tundrenone	Methylobacter tundripaludum 21/22
BGC0001437.1	0.27	NRP	obafluorin	Pseudomonas fluorescens

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

Selected features only

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c00021_NZ_LOWL.. - Region 1 - arylpolyene

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Location: 83,708 - 128,571 nt. (total: 44,864 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002008.1	0.29	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.1	0.28	Other	APE Ec	Escherichia coli CFT073
BGC0002029.1	0.24	Other	bagremycin A, bagremycin B, bagremycin C, bagremycin E, bagremycin F, bagremycin G, ferroverdin A, ferroverdin B, ferroverdin C	Streptomyces lunaelactis
BGC0001592.1	0.24	Other	ferroverdin	Streptomyces lunaelactis
BGC0000231.1	0.24	Polyketide	griseusin	Streptomyces griseus
BGC0000889.1	0.24	Other	bagremycin A, bagremycin B	Streptomyces sp. WK-5344
BGC0000904.1	0.23	Other	FR-900098	Streptomyces rubellomurinus
BGC0000221.1	0.23	Polyketide	erdacin	uncultured soil bacterium V167
BGC0000194.1	0.22	Polyketide	actinorhodin	Streptomyces coelicolor A3(2)
BGC0000248.1	0.22	Polyketide	naphtocyclinone	Streptomyces arenae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002008.1	0.62	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.1	0.61	Other	APE Ec	Escherichia coli CFT073
BGC0002029.1	0.58	Other	bagremycin A, bagremycin B, bagremycin C, bagremycin E, bagremycin F, bagremycin G, ferroverdin A, ferroverdin B, ferroverdin C	Streptomyces lunaelactis
BGC0001592.1	0.58	Other	ferroverdin	Streptomyces lunaelactis
BGC0000231.1	0.58	Polyketide	griseusin	Streptomyces griseus
BGC0000889.1	0.57	Other	bagremycin A, bagremycin B	Streptomyces sp. WK-5344
BGC0000904.1	0.57	Other	FR-900098	Streptomyces rubellomurinus
BGC0000221.1	0.56	Polyketide	erdacin	uncultured soil bacterium V167
BGC0000194.1	0.55	Polyketide	actinorhodin	Streptomyces coelicolor A3(2)
BGC0000248.1	0.55	Polyketide	naphtocyclinone	Streptomyces arenae

Similar known gene clusters

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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c00021_NZ_LOWL.. - Region 2 - NRPS,NRPS-like,T1PKS

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Location: 196,487 - 280,952 nt. (total: 84,466 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

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regulatory genes

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NRPS/PKS domains

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KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001711.1	1.18	NRP, Polyketide	occidiofungin A	Burkholderia pyrrocinia
BGC0000389.1	0.88	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001050.1	0.88	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001479.1	0.86	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000041.1	0.86	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000426.1	0.84	NRP	sevadicin	Paenibacillus larvae
BGC0001132.1	0.83	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001023.1	0.82	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca
BGC0001185.1	0.82	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001790.1	0.82	NRP	sulfazecin	Pseudomonas acidophila

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001711.1	0.81	NRP, Polyketide	occidiofungin A	Burkholderia pyrrocinia
BGC0000426.1	0.73	NRP	sevadicin	Paenibacillus larvae
BGC0001479.1	0.69	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000427.1	0.68	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000375.1	0.68	NRP	indigoidine	Streptomyces chromofuscus
BGC0000980.1	0.67	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0000979.1	0.67	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000457.1	0.67	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000901.1	0.66	Other	ferrichrome	Aspergillus niger
BGC0001050.1	0.66	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis

Similar known gene clusters

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Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 2, location 196486 - 280952:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal - ser) + (D-X) + (D-X - phe) + (asn - D-ser)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 196486 - 238355:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal - ser) + (D-X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 203249 - 280952:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal - ser) + (D-X) + (D-X - phe) + (asn - D-ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg21_230

CAL_domain (40..481): pk

minowa: NH2

Prediction, score:

NH2: 167.5
fatty_acid: 18.2
AHBA: 8.9
Acetyl-CoA: 3.0
shikimic_acid: 0.0

ctg21_232

Search NORINE for peptide: strict or relaxed

PKS_AT (1945..2227): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 177.2
inactive: 136.0
Methoxymalonyl-CoA: 79.9
Methylmalonyl-CoA: 78.6
Propionyl-CoA: 63.3
Isobutyryl-CoA: 51.8
CHC-CoA: 40.8
Ethylmalonyl-CoA: 37.3
2-Methylbutyryl-CoA: 32.0
fatty_acid: 29.4
Acetyl-CoA: 27.3
Benzoyl-CoA: 20.1
trans-1,2-CPDA: 15.8
3-Methylbutyryl-CoA: 13.5

AMP-binding (3444..3845): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHVSLVDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

ctg21_234

Search NORINE for peptide: strict or relaxed

AMP-binding (260..654): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DGmniASVCK
Nearest Stachelhaus code:: trp
Stachelhaus code match:: 70% (weak)

ctg21_235

Search NORINE for peptide: strict or relaxed

AMP-binding (472..874): X

NRPSPredictor2: hydrophilic

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DiWeLtadDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 50% (weak)

AMP-binding (1969..2372): phe

NRPSPredictor2: phe

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: phe

Stachelhaus prediction details:

Stachelhaus sequence:: DIwQLiadsK
Nearest Stachelhaus code:: gly
Stachelhaus code match:: 50% (weak)

ctg21_236

Search NORINE for peptide: strict or relaxed

AMP-binding (257..653): asn

NRPSPredictor2: asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: asn

Stachelhaus prediction details:

Stachelhaus sequence:: DFTKIGEVGK
Nearest Stachelhaus code:: asn
Stachelhaus code match:: 100% (strong)

AMP-binding (1303..1704): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHVSLVDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

c00022_NZ_LOWL.. - Region 1 - redox-cofactor

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Location: 3,583 - 25,706 nt. (total: 22,124 nt) Show pHMM detection rules used

redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000601.1	0.22	RiPP	sporulation killing factor	Bacillus subtilis subsp. subtilis str. 168
BGC0001496.1	0.20	RiPP	actinokineosin	Actinokineospora spheciospongiae
BGC0001634.1	0.20	RiPP	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001655.1	0.20	RiPP	LP2006	Nocardiopsis alba DSM 43377
BGC0001551.1	0.20	RiPP	citrulassin E	Streptomyces glaucescens
BGC0001549.1	0.19	RiPP	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0001176.1	0.19	RiPP	streptomonomicin	Streptomonospora alba
BGC0001550.1	0.19	RiPP	citrulassin D	Streptomyces katrae
BGC0001356.1	0.18	RiPP	paeninodin	Paenibacillus dendritiformis C454
BGC0002015.1	0.18	RiPP	aborycin	Streptomyces sp. ZS0098

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000601.1	0.55	RiPP	sporulation killing factor	Bacillus subtilis subsp. subtilis str. 168
BGC0001496.1	0.52	RiPP	actinokineosin	Actinokineospora spheciospongiae
BGC0001634.1	0.52	RiPP	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001655.1	0.52	RiPP	LP2006	Nocardiopsis alba DSM 43377
BGC0001551.1	0.52	RiPP	citrulassin E	Streptomyces glaucescens
BGC0001549.1	0.52	RiPP	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0001176.1	0.52	RiPP	streptomonomicin	Streptomonospora alba
BGC0001550.1	0.51	RiPP	citrulassin D	Streptomyces katrae
BGC0001356.1	0.50	RiPP	paeninodin	Paenibacillus dendritiformis C454
BGC0002015.1	0.50	RiPP	aborycin	Streptomyces sp. ZS0098

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c00027_NZ_LOWL.. - Region 1 - phosphonate

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Location: 96,040 - 137,725 nt. (total: 41,686 nt) Show pHMM detection rules used

phosphonate: phosphonates

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0001859.1	0.28	Other (Phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000904.1	0.24	Other	FR-900098	Streptomyces rubellomurinus
BGC0001739.1	0.20	Other	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0002036.1	0.17	Other	dehydrofosmidomycin	Streptomyces lavendulae
BGC0001475.1	0.17	Polyketide	aspterric acid	Aspergillus terreus NIH2624
BGC0000937.1	0.16	Other	fosfazinomycin A	Streptomyces sp. WM6372
BGC0000897.1	0.16	Other	dehydrophos	Streptomyces luridus
BGC0001928.1	0.15	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000884.1	0.14	Other	3-methylarginine	Pseudomonas syringae pv. syringae
BGC0001289.1	0.14	RiPP	penisin	Paenibacillus ehimensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001859.1	0.62	Other (Phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000904.1	0.57	Other	FR-900098	Streptomyces rubellomurinus
BGC0001739.1	0.52	Other	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0002036.1	0.48	Other	dehydrofosmidomycin	Streptomyces lavendulae
BGC0001475.1	0.48	Polyketide	aspterric acid	Aspergillus terreus NIH2624
BGC0000937.1	0.47	Other	fosfazinomycin A	Streptomyces sp. WM6372
BGC0000897.1	0.47	Other	dehydrophos	Streptomyces luridus
BGC0001928.1	0.44	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000884.1	0.43	Other	3-methylarginine	Pseudomonas syringae pv. syringae
BGC0001289.1	0.43	RiPP	penisin	Paenibacillus ehimensis

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c00032_NZ_LOWL.. - Region 1 - arylpolyene

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Location: 150,436 - 175,279 nt. (total: 24,844 nt) Show pHMM detection rules used

Region on contig edge.

arylpolyene: (APE_KS1 or APE_KS2)

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0000866.1	0.25	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000886.1	0.23	Other	allylmalonyl-CoA	Streptomyces tsukubensis
BGC0000231.1	0.22	Polyketide	griseusin	Streptomyces griseus
BGC0001723.1	0.22	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0001947.1	0.21	Saccharide	K53 capsular polysaccharide	Acinetobacter baumannii
BGC0000234.1	0.21	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001197.1	0.21	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0001897.1	0.20	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0001895.1	0.20	Polyketide	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0000867.1	0.19	Other	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000866.1	0.58	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000886.1	0.56	Other	allylmalonyl-CoA	Streptomyces tsukubensis
BGC0000231.1	0.55	Polyketide	griseusin	Streptomyces griseus
BGC0001723.1	0.55	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0001947.1	0.54	Saccharide	K53 capsular polysaccharide	Acinetobacter baumannii
BGC0000234.1	0.54	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001197.1	0.53	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0001897.1	0.52	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0001895.1	0.52	Polyketide	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0000867.1	0.52	Other	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii

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c00033_NZ_LOWL.. - Region 1 - terpene

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Location: 153,523 - 177,621 nt. (total: 24,099 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0000648.1	0.33	Terpene	carotenoid	Myxococcus xanthus
BGC0000647.1	0.32	Terpene	carotenoid	Rhodobacter sphaeroides
BGC0000646.1	0.25	Terpene	β-carotein	uncultured bacterium
BGC0000645.1	0.20	Terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000495.1	0.17	RiPP	actagardine	Actinoplanes garbadinensis
BGC0001586.1	0.16	Saccharide	EPS273	Pseudomonas stutzeri
BGC0001765.1	0.15	Saccharide	salecan	Agrobacterium tumefaciens
BGC0001380.1	0.15	Saccharide	salecan	Agrobacterium sp. ZX09
BGC0001374.1	0.15	Other	thienodolin	Streptomyces albogriseolus
BGC0000874.1	0.15	Other	blasticidin S	Streptomyces griseochromogenes

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000648.1	0.66	Terpene	carotenoid	Myxococcus xanthus
BGC0000647.1	0.65	Terpene	carotenoid	Rhodobacter sphaeroides
BGC0000646.1	0.58	Terpene	β-carotein	uncultured bacterium
BGC0000645.1	0.53	Terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000495.1	0.48	RiPP	actagardine	Actinoplanes garbadinensis
BGC0001586.1	0.47	Saccharide	EPS273	Pseudomonas stutzeri
BGC0001765.1	0.45	Saccharide	salecan	Agrobacterium tumefaciens
BGC0001380.1	0.45	Saccharide	salecan	Agrobacterium sp. ZX09
BGC0001374.1	0.45	Other	thienodolin	Streptomyces albogriseolus
BGC0000874.1	0.44	Other	blasticidin S	Streptomyces griseochromogenes

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c00038_NZ_LOWL.. - Region 1 - RiPP-like

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Location: 51,071 - 61,886 nt. (total: 10,816 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0001882.1	0.18	Polyketide	chrysoxanthone A, chrysoxanthone B, chrysoxanthone C	Penicillium rubens Wisconsin 54-1255
BGC0000145.1	0.04	Polyketide	salinosporamide A	Salinispora tropica
BGC0000175.1	0.04	Polyketide	cycloheximide	Streptomyces sp. YIM 56141
BGC0001041.1	0.04	NRP, Polyketide	salinosporamide A	Salinispora tropica CNB-440
BGC0000446.1	0.04	NRP	tilivalline, 9-deoxy tilivalline, dihydroxy tilivalline, dehydro tilivalline, dihydroxy-dehydro tilivalline	Klebsiella oxytoca
BGC0001805.1	0.04	NRP	tilivalline	Klebsiella oxytoca
BGC0000148.1	0.03	Polyketide	A83543A	Saccharopolyspora spinosa

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001882.1	0.50	Polyketide	chrysoxanthone A, chrysoxanthone B, chrysoxanthone C	Penicillium rubens Wisconsin 54-1255
BGC0000145.1	0.21	Polyketide	salinosporamide A	Salinispora tropica
BGC0000175.1	0.20	Polyketide	cycloheximide	Streptomyces sp. YIM 56141
BGC0001041.1	0.18	NRP, Polyketide	salinosporamide A	Salinispora tropica CNB-440
BGC0000446.1	0.17	NRP	tilivalline, 9-deoxy tilivalline, dihydroxy tilivalline, dehydro tilivalline, dihydroxy-dehydro tilivalline	Klebsiella oxytoca
BGC0001805.1	0.17	NRP	tilivalline	Klebsiella oxytoca
BGC0000148.1	0.16	Polyketide	A83543A	Saccharopolyspora spinosa

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c00042_NZ_LOWL.. - Region 1 - hserlactone

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Location: 94,196 - 114,855 nt. (total: 20,660 nt) Show pHMM detection rules used

hserlactone: Autoind_synth

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0001897.1	0.45	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0000888.1	0.26	Other	bacilysin	Bacillus sp. CS93
BGC0001184.1	0.26	Other	bacilysin	Bacillus velezensis FZB42
BGC0001444.1	0.21	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001521.1	0.21	NRP	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0001197.1	0.20	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0000892.1	0.18	Other	caryoynencin	Burkholderia gladioli BSR3
BGC0001241.1	0.17	Terpene	ergotamine	Claviceps fusiformis
BGC0001267.1	0.17	Terpene	lysergic acid, elymoclavine	Claviceps fusiformis
BGC0000679.1	0.17	Terpene	diazepinomicin	Micromonospora sp. M42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001897.1	0.75	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0000888.1	0.60	Other	bacilysin	Bacillus sp. CS93
BGC0001184.1	0.60	Other	bacilysin	Bacillus velezensis FZB42
BGC0001444.1	0.54	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001521.1	0.54	NRP	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0001197.1	0.53	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0000892.1	0.49	Other	caryoynencin	Burkholderia gladioli BSR3
BGC0001241.1	0.49	Terpene	ergotamine	Claviceps fusiformis
BGC0001267.1	0.49	Terpene	lysergic acid, elymoclavine	Claviceps fusiformis
BGC0000679.1	0.49	Terpene	diazepinomicin	Micromonospora sp. M42

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c00049_NZ_LOWL.. - Region 1 - NRPS

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Location: 34,446 - 89,196 nt. (total: 54,751 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

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Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001721.1	0.59	NRP	ornibactin	Burkholderia cepacia
BGC0000426.1	0.36	NRP	sevadicin	Paenibacillus larvae
BGC0000389.1	0.35	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001479.1	0.33	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000427.1	0.33	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001561.1	0.32	NRP	curacomycin	Streptomyces curacoi
BGC0000348.1	0.31	NRP	ergovaline	Epichloe festucae var. lolii
BGC0000901.1	0.31	Other	ferrichrome	Aspergillus niger
BGC0001261.1	0.31	NRP	AM-toxin	Alternaria alternata
BGC0000900.1	0.31	Other	ferrichrome	Aspergillus oryzae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001721.1	0.83	NRP	ornibactin	Burkholderia cepacia
BGC0000426.1	0.69	NRP	sevadicin	Paenibacillus larvae
BGC0000389.1	0.68	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001479.1	0.66	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000427.1	0.66	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001561.1	0.65	NRP	curacomycin	Streptomyces curacoi
BGC0000348.1	0.64	NRP	ergovaline	Epichloe festucae var. lolii
BGC0000901.1	0.64	Other	ferrichrome	Aspergillus niger
BGC0001261.1	0.64	NRP	AM-toxin	Alternaria alternata
BGC0000900.1	0.64	Other	ferrichrome	Aspergillus oryzae

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 34445 - 89196:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - D-asp - ser) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg49_50

Search NORINE for peptide: strict or relaxed

AMP-binding (517..923): X

NRPSPredictor2: asp, asn, glu, gln, aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DGeYTGgitK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 60% (weak)

ctg49_51

Search NORINE for peptide: strict or relaxed

AMP-binding (15..429): X

NRPSPredictor2: asp, asn, glu, gln, aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAeAaGGisK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 60% (weak)

AMP-binding (1101..1507): asp

NRPSPredictor2: asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: asp

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKVGHVGK
Nearest Stachelhaus code:: asp
Stachelhaus code match:: 100% (strong)

AMP-binding (2634..3052): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHVSLIDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

c00052_NZ_LOWL.. - Region 1 - terpene

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Location: 95,116 - 116,021 nt. (total: 20,906 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

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Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000648.1	0.23	Terpene	carotenoid	Myxococcus xanthus
BGC0000928.1	0.16	Other	T3 toxin	Cylindrospermopsis raciborskii T3
BGC0000188.1	0.16	Alkaloid	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0001456.1	0.14	Terpene	isorenieratene	Streptomyces argillaceus
BGC0000633.1	0.14	Terpene	carotenoid	Streptomyces avermitilis
BGC0000043.1	0.12	Polyketide	curacin A	Moorea producens 19L
BGC0000545.1	0.09	RiPP	ruminococcin A	[Ruminococcus] gnavus E1
BGC0001727.1	0.09	RiPP	paenilan	Paenibacillus polymyxa E681
BGC0000897.1	0.09	Other	dehydrophos	Streptomyces luridus
BGC0000842.1	0.09	Other (Non-NRP beta-lactam)	carbapenem MM4550	Streptomyces argenteolus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000648.1	0.56	Terpene	carotenoid	Myxococcus xanthus
BGC0000928.1	0.47	Other	T3 toxin	Cylindrospermopsis raciborskii T3
BGC0000188.1	0.47	Alkaloid	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0001456.1	0.44	Terpene	isorenieratene	Streptomyces argillaceus
BGC0000633.1	0.43	Terpene	carotenoid	Streptomyces avermitilis
BGC0000043.1	0.39	Polyketide	curacin A	Moorea producens 19L
BGC0000545.1	0.34	RiPP	ruminococcin A	[Ruminococcus] gnavus E1
BGC0001727.1	0.34	RiPP	paenilan	Paenibacillus polymyxa E681
BGC0000897.1	0.34	Other	dehydrophos	Streptomyces luridus
BGC0000842.1	0.33	Other (Non-NRP beta-lactam)	carbapenem MM4550	Streptomyces argenteolus

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