Select genomic region:
Overview
16.1
20.1
21.1
21.2
22.1
27.1
32.1
33.1
38.1
42.1
49.1
52.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_LOWL01000017 (original name was: NZ_LOWL01000017.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 16.1 | terpene | 165,549 | 186,616 |

NZ_LOWL01000022 (original name was: NZ_LOWL01000022.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 20.1 | hserlactone | 44,400 | 65,008 |

NZ_LOWL01000024 (original name was: NZ_LOWL01000024.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 21.1 | arylpolyene | 83,708 | 128,571 | APE Vf | Other | 35%
Region 21.2 | NRPS-like,NRPS,T1PKS | 196,487 | 280,952 | occidiofungin A | NRP + Polyketide | 94%

NZ_LOWL01000025 (original name was: NZ_LOWL01000025.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 22.1 | redox-cofactor | 3,583 | 25,706 | lankacidin C | NRP + Polyketide | 13%

NZ_LOWL01000030 (original name was: NZ_LOWL01000030.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 27.1 | phosphonate | 96,040 | 137,725 | phosphinothricintripeptide | NRP | 6%

NZ_LOWL01000036 (original name was: NZ_LOWL01000036.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 32.1 | arylpolyene | 150,436 | 175,279 | APE Vf | Other | 10%

NZ_LOWL01000037 (original name was: NZ_LOWL01000037.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 33.1 | terpene | 153,523 | 177,621 |

NZ_LOWL01000042 (original name was: NZ_LOWL01000042.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 38.1 | RiPP-like | 51,071 | 61,886 |

NZ_LOWL01000046 (original name was: NZ_LOWL01000046.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 42.1 | hserlactone | 94,196 | 114,855 | cepacin A | Polyketide | 62%

NZ_LOWL01000056 (original name was: NZ_LOWL01000056.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 49.1 | NRPS | 34,446 | 89,196 | ornibactin | NRP | 93%

NZ_LOWL01000059 (original name was: NZ_LOWL01000059.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 52.1 | terpene | 95,116 | 116,021 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 16.1 | terpene | 165,549 | 186,616 |
Region 20.1 | hserlactone | 44,400 | 65,008 |
Region 21.1 | arylpolyene | 83,708 | 128,571 | APE Vf | Other | 35%
Region 21.2 | NRPS-like,NRPS,T1PKS | 196,487 | 280,952 | occidiofungin A | NRP + Polyketide | 94%
Region 22.1 | redox-cofactor | 3,583 | 25,706 | lankacidin C | NRP + Polyketide | 13%
Region 27.1 | phosphonate | 96,040 | 137,725 | phosphinothricintripeptide | NRP | 6%
Region 32.1 | arylpolyene | 150,436 | 175,279 | APE Vf | Other | 10%
Region 33.1 | terpene | 153,523 | 177,621 |
Region 38.1 | RiPP-like | 51,071 | 61,886 |
Region 42.1 | hserlactone | 94,196 | 114,855 | cepacin A | Polyketide | 62%
Region 49.1 | NRPS | 34,446 | 89,196 | ornibactin | NRP | 93%
Region 52.1 | terpene | 95,116 | 116,021 |

No secondary metabolite regions were found in these records:
  NZ_LOWL01000001 (original name was: NZ_LOWL01000001.1)
  NZ_LOWL01000002 (original name was: NZ_LOWL01000002.1)
  NZ_LOWL01000003 (original name was: NZ_LOWL01000003.1)
  NZ_LOWL01000004 (original name was: NZ_LOWL01000004.1)
  NZ_LOWL01000005 (original name was: NZ_LOWL01000005.1)
  NZ_LOWL01000007 (original name was: NZ_LOWL01000007.1)
  NZ_LOWL01000008 (original name was: NZ_LOWL01000008.1)
  NZ_LOWL01000009 (original name was: NZ_LOWL01000009.1)
  NZ_LOWL01000010 (original name was: NZ_LOWL01000010.1)
  NZ_LOWL01000011 (original name was: NZ_LOWL01000011.1)
  NZ_LOWL01000012 (original name was: NZ_LOWL01000012.1)
  NZ_LOWL01000013 (original name was: NZ_LOWL01000013.1)
  NZ_LOWL01000014 (original name was: NZ_LOWL01000014.1)
  NZ_LOWL01000015 (original name was: NZ_LOWL01000015.1)
  NZ_LOWL01000016 (original name was: NZ_LOWL01000016.1)
  NZ_LOWL01000018 (original name was: NZ_LOWL01000018.1)
  NZ_LOWL01000020 (original name was: NZ_LOWL01000020.1)
  NZ_LOWL01000021 (original name was: NZ_LOWL01000021.1)
  NZ_LOWL01000026 (original name was: NZ_LOWL01000026.1)
  NZ_LOWL01000027 (original name was: NZ_LOWL01000027.1)
  NZ_LOWL01000028 (original name was: NZ_LOWL01000028.1)
  NZ_LOWL01000029 (original name was: NZ_LOWL01000029.1)
  NZ_LOWL01000031 (original name was: NZ_LOWL01000031.1)
  NZ_LOWL01000032 (original name was: NZ_LOWL01000032.1)
  NZ_LOWL01000034 (original name was: NZ_LOWL01000034.1)
  NZ_LOWL01000035 (original name was: NZ_LOWL01000035.1)
  NZ_LOWL01000038 (original name was: NZ_LOWL01000038.1)
  NZ_LOWL01000039 (original name was: NZ_LOWL01000039.1)
  NZ_LOWL01000040 (original name was: NZ_LOWL01000040.1)
  NZ_LOWL01000041 (original name was: NZ_LOWL01000041.1)
  NZ_LOWL01000043 (original name was: NZ_LOWL01000043.1)
  NZ_LOWL01000044 (original name was: NZ_LOWL01000044.1)
  NZ_LOWL01000045 (original name was: NZ_LOWL01000045.1)
  NZ_LOWL01000047 (original name was: NZ_LOWL01000047.1)
  NZ_LOWL01000048 (original name was: NZ_LOWL01000048.1)
  NZ_LOWL01000051 (original name was: NZ_LOWL01000051.1)
  NZ_LOWL01000052 (original name was: NZ_LOWL01000052.1)
  NZ_LOWL01000053 (original name was: NZ_LOWL01000053.1)
  NZ_LOWL01000054 (original name was: NZ_LOWL01000054.1)
  NZ_LOWL01000057 (original name was: NZ_LOWL01000057.1)
  NZ_LOWL01000058 (original name was: NZ_LOWL01000058.1)
  NZ_LOWL01000060 (original name was: NZ_LOWL01000060.1)
  NZ_LOWL01000061 (original name was: NZ_LOWL01000061.1)
  NZ_LOWL01000063 (original name was: NZ_LOWL01000063.1)
  NZ_LOWL01000064 (original name was: NZ_LOWL01000064.1)

Compact view
c00016_NZ_LOWL.. - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 165,549 - 186,616 nt. (total: 21,068 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000648.1 |  | 0.34 | Terpene | carotenoid | Myxococcus xanthus
BGC0000647.1 |  | 0.31 | Terpene | carotenoid | Rhodobacter sphaeroides
BGC0000888.1 |  | 0.22 | Other | bacilysin | Bacillus sp. CS93
BGC0001184.1 |  | 0.22 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000643.1 |  | 0.21 | Terpene | carotenoid | Brevundimonas vesicularis
BGC0001928.1 |  | 0.19 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001444.1 |  | 0.19 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001538.1 |  | 0.19 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0000630.1 |  | 0.19 | Terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000886.1 |  | 0.19 | Other | allylmalonyl-CoA | Streptomyces tsukubensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000648.1 |  | 0.67 | Terpene | carotenoid | Myxococcus xanthus
BGC0000647.1 |  | 0.65 | Terpene | carotenoid | Rhodobacter sphaeroides
BGC0000888.1 |  | 0.54 | Other | bacilysin | Bacillus sp. CS93
BGC0001184.1 |  | 0.54 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000643.1 |  | 0.54 | Terpene | carotenoid | Brevundimonas vesicularis
BGC0001928.1 |  | 0.51 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001444.1 |  | 0.51 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001538.1 |  | 0.51 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0000630.1 |  | 0.51 | Terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000886.1 |  | 0.51 | Other | allylmalonyl-CoA | Streptomyces tsukubensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00020_NZ_LOWL.. - Region 1 - hserlactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 44,400 - 65,008 nt. (total: 20,609 nt) Show pHMM detection rules used
hserlactone: Autoind_synth

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | hserlactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000785.1 |  | 0.20 | Saccharide | O-antigen | Burkholderia mallei
BGC0001973.1 |  | 0.19 | Other | fervenulin | Streptomyces hiroshimensis
BGC0001972.1 |  | 0.19 | Other | toxoflavin, fervenulin | Streptomyces hiroshimensis
BGC0000929.1 |  | 0.18 | Other | xanthothricin | Burkholderia glumae
BGC0001959.1 |  | 0.18 | Other | taylorflavin A, taylorflavin B | Streptomyces hiroshimensis
BGC0000772.1 |  | 0.17 | Saccharide | lipopolysaccharide | Brucella melitensis
BGC0001897.1 |  | 0.12 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001671.1 |  | 0.08 | NRP | monobactam | Agrobacterium tumefaciens
BGC0001480.1 |  | 0.07 | Other | tundrenone | Methylobacter tundripaludum 21/22
BGC0001437.1 |  | 0.06 | NRP | obafluorin | Pseudomonas fluorescens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000785.1 |  | 0.52 | Saccharide | O-antigen | Burkholderia mallei
BGC0001973.1 |  | 0.51 | Other | fervenulin | Streptomyces hiroshimensis
BGC0001972.1 |  | 0.51 | Other | toxoflavin, fervenulin | Streptomyces hiroshimensis
BGC0000929.1 |  | 0.50 | Other | xanthothricin | Burkholderia glumae
BGC0001959.1 |  | 0.50 | Other | taylorflavin A, taylorflavin B | Streptomyces hiroshimensis
BGC0000772.1 |  | 0.49 | Saccharide | lipopolysaccharide | Brucella melitensis
BGC0001897.1 |  | 0.40 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001671.1 |  | 0.30 | NRP | monobactam | Agrobacterium tumefaciens
BGC0001480.1 |  | 0.27 | Other | tundrenone | Methylobacter tundripaludum 21/22
BGC0001437.1 |  | 0.27 | NRP | obafluorin | Pseudomonas fluorescens

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00021_NZ_LOWL.. - Region 1 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 83,708 - 128,571 nt. (total: 44,864 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002008.1 |  | 0.29 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0000836.1 |  | 0.28 | Other | APE Ec | Escherichia coli CFT073
BGC0002029.1 |  | 0.24 | Other | bagremycin A, bagremycin B, bagremycin C, bagremycin E, bagremycin F, bagremycin G, ferroverdin A, ferroverdin B, ferroverdin C | Streptomyces lunaelactis
BGC0001592.1 |  | 0.24 | Other | ferroverdin | Streptomyces lunaelactis
BGC0000231.1 |  | 0.24 | Polyketide | griseusin | Streptomyces griseus
BGC0000889.1 |  | 0.24 | Other | bagremycin A, bagremycin B | Streptomyces sp. WK-5344
BGC0000904.1 |  | 0.23 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0000221.1 |  | 0.23 | Polyketide | erdacin | uncultured soil bacterium V167
BGC0000194.1 |  | 0.22 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)
BGC0000248.1 |  | 0.22 | Polyketide | naphtocyclinone | Streptomyces arenae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002008.1 |  | 0.62 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0000836.1 |  | 0.61 | Other | APE Ec | Escherichia coli CFT073
BGC0002029.1 |  | 0.58 | Other | bagremycin A, bagremycin B, bagremycin C, bagremycin E, bagremycin F, bagremycin G, ferroverdin A, ferroverdin B, ferroverdin C | Streptomyces lunaelactis
BGC0001592.1 |  | 0.58 | Other | ferroverdin | Streptomyces lunaelactis
BGC0000231.1 |  | 0.58 | Polyketide | griseusin | Streptomyces griseus
BGC0000889.1 |  | 0.57 | Other | bagremycin A, bagremycin B | Streptomyces sp. WK-5344
BGC0000904.1 |  | 0.57 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0000221.1 |  | 0.56 | Polyketide | erdacin | uncultured soil bacterium V167
BGC0000194.1 |  | 0.55 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)
BGC0000248.1 |  | 0.55 | Polyketide | naphtocyclinone | Streptomyces arenae

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00021_NZ_LOWL.. - Region 2 - NRPS,NRPS-like,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 196,487 - 280,952 nt. (total: 84,466 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | NRPS | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0001711.1 |  |  |  | 1.18 | NRP, Polyketide | occidiofungin A | Burkholderia pyrrocinia
BGC0000389.1 |  |  |  | 0.88 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001050.1 |  |  |  | 0.88 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0001479.1 |  |  |  | 0.86 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000041.1 |  |  |  | 0.86 | Polyketide | oronofacic acid | Pseudomonas syringae
BGC0000426.1 |  |  |  | 0.84 | NRP | sevadicin | Paenibacillus larvae
BGC0001132.1 |  |  |  | 0.83 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001023.1 |  |  |  | 0.82 | NRP, Polyketide | myxochromide S1 | Stigmatella aurantiaca
BGC0001185.1 |  |  |  | 0.82 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0001790.1 |  |  |  | 0.82 | NRP | sulfazecin | Pseudomonas acidophila

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001711.1 |  | 0.81 | NRP, Polyketide | occidiofungin A | Burkholderia pyrrocinia
BGC0000426.1 |  | 0.73 | NRP | sevadicin | Paenibacillus larvae
BGC0001479.1 |  | 0.69 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000427.1 |  | 0.68 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.68 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000980.1 |  | 0.67 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0000979.1 |  | 0.67 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000457.1 |  | 0.67 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0000901.1 |  | 0.66 | Other | ferrichrome | Aspergillus niger
BGC0001050.1 |  | 0.66 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 196486 - 280952:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal - ser) + (D-X) + (D-X - phe) + (asn - D-ser)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 196486 - 238355:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal - ser) + (D-X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 203249 - 280952:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal - ser) + (D-X) + (D-X - phe) + (asn - D-ser)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg21_230: pk
  CAL_domain (40..481): pk
  minowa: NH2
  Prediction, score:
    NH2: 167.5
    fatty_acid: 18.2
    AHBA: 8.9
    Acetyl-CoA: 3.0
    shikimic_acid: 0.0
ctg21_232: mal - ser
  Search NORINE for peptide: strict or relaxed
  PKS_AT (1945..2227): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 91.7%
    inactive: 87.5%
    2-Rhyd-Malonyl-CoA: 54.2%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 177.2
    inactive: 136.0
    Methoxymalonyl-CoA: 79.9
    Methylmalonyl-CoA: 78.6
    Propionyl-CoA: 63.3
    Isobutyryl-CoA: 51.8
    CHC-CoA: 40.8
    Ethylmalonyl-CoA: 37.3
    2-Methylbutyryl-CoA: 32.0
    fatty_acid: 29.4
    Acetyl-CoA: 27.3
    Benzoyl-CoA: 20.1
    trans-1,2-CPDA: 15.8
    3-Methylbutyryl-CoA: 13.5
  AMP-binding (3444..3845): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHVSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
ctg21_234: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (260..654): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGmniASVCK
    Nearest Stachelhaus code:
      trp
    Stachelhaus code match:
      70% (weak)
ctg21_235: X - phe
  Search NORINE for peptide: strict or relaxed
  AMP-binding (472..874): X
  NRPSPredictor2: hydrophilic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DiWeLtadDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      50% (weak)
  AMP-binding (1969..2372): phe
  NRPSPredictor2: phe
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      phe
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DIwQLiadsK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      50% (weak)
ctg21_236: asn - ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (257..653): asn
  NRPSPredictor2: asn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      asp, asn
    Single AA prediction:
      asn
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFTKIGEVGK
    Nearest Stachelhaus code:
      asn
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1303..1704): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHVSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)

c00022_NZ_LOWL.. - Region 1 - redox-cofactor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,583 - 25,706 nt. (total: 22,124 nt) Show pHMM detection rules used
redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | redox-cofactor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000601.1 |  | 0.22 | RiPP | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168
BGC0001496.1 |  | 0.20 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0001634.1 |  | 0.20 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0001655.1 |  | 0.20 | RiPP | LP2006 | Nocardiopsis alba DSM 43377
BGC0001551.1 |  | 0.20 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0001549.1 |  | 0.19 | RiPP | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0001176.1 |  | 0.19 | RiPP | streptomonomicin | Streptomonospora alba
BGC0001550.1 |  | 0.19 | RiPP | citrulassin D | Streptomyces katrae
BGC0001356.1 |  | 0.18 | RiPP | paeninodin | Paenibacillus dendritiformis C454
BGC0002015.1 |  | 0.18 | RiPP | aborycin | Streptomyces sp. ZS0098

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000601.1 |  | 0.55 | RiPP | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168
BGC0001496.1 |  | 0.52 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0001634.1 |  | 0.52 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0001655.1 |  | 0.52 | RiPP | LP2006 | Nocardiopsis alba DSM 43377
BGC0001551.1 |  | 0.52 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0001549.1 |  | 0.52 | RiPP | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0001176.1 |  | 0.52 | RiPP | streptomonomicin | Streptomonospora alba
BGC0001550.1 |  | 0.51 | RiPP | citrulassin D | Streptomyces katrae
BGC0001356.1 |  | 0.50 | RiPP | paeninodin | Paenibacillus dendritiformis C454
BGC0002015.1 |  | 0.50 | RiPP | aborycin | Streptomyces sp. ZS0098

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00027_NZ_LOWL.. - Region 1 - phosphonate
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 96,040 - 137,725 nt. (total: 41,686 nt) Show pHMM detection rules used
phosphonate: phosphonates

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | phosphonate | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001859.1 |  | 0.28 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000904.1 |  | 0.24 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0001739.1 |  | 0.20 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0002036.1 |  | 0.17 | Other | dehydrofosmidomycin | Streptomyces lavendulae
BGC0001475.1 |  | 0.17 | Polyketide | aspterric acid | Aspergillus terreus NIH2624
BGC0000937.1 |  | 0.16 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0000897.1 |  | 0.16 | Other | dehydrophos | Streptomyces luridus
BGC0001928.1 |  | 0.15 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000884.1 |  | 0.14 | Other | 3-methylarginine | Pseudomonas syringae pv. syringae
BGC0001289.1 |  | 0.14 | RiPP | penisin | Paenibacillus ehimensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001859.1 |  | 0.62 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000904.1 |  | 0.57 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0001739.1 |  | 0.52 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0002036.1 |  | 0.48 | Other | dehydrofosmidomycin | Streptomyces lavendulae
BGC0001475.1 |  | 0.48 | Polyketide | aspterric acid | Aspergillus terreus NIH2624
BGC0000937.1 |  | 0.47 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0000897.1 |  | 0.47 | Other | dehydrophos | Streptomyces luridus
BGC0001928.1 |  | 0.44 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000884.1 |  | 0.43 | Other | 3-methylarginine | Pseudomonas syringae pv. syringae
BGC0001289.1 |  | 0.43 | RiPP | penisin | Paenibacillus ehimensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00032_NZ_LOWL.. - Region 1 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 150,436 - 175,279 nt. (total: 24,844 nt) Show pHMM detection rules used
Region on contig edge.
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000866.1 |  | 0.25 | Other | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0000886.1 |  | 0.23 | Other | allylmalonyl-CoA | Streptomyces tsukubensis
BGC0000231.1 |  | 0.22 | Polyketide | griseusin | Streptomyces griseus
BGC0001723.1 |  | 0.22 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0001947.1 |  | 0.21 | Saccharide | K53 capsular polysaccharide | Acinetobacter baumannii
BGC0000234.1 |  | 0.21 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0001197.1 |  | 0.21 | Polyketide | frankiamicin | Frankia sp. EAN1pec
BGC0001897.1 |  | 0.20 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001895.1 |  | 0.20 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0000867.1 |  | 0.19 | Other | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000866.1 |  | 0.58 | Other | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0000886.1 |  | 0.56 | Other | allylmalonyl-CoA | Streptomyces tsukubensis
BGC0000231.1 |  | 0.55 | Polyketide | griseusin | Streptomyces griseus
BGC0001723.1 |  | 0.55 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0001947.1 |  | 0.54 | Saccharide | K53 capsular polysaccharide | Acinetobacter baumannii
BGC0000234.1 |  | 0.54 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0001197.1 |  | 0.53 | Polyketide | frankiamicin | Frankia sp. EAN1pec
BGC0001897.1 |  | 0.52 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001895.1 |  | 0.52 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0000867.1 |  | 0.52 | Other | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00033_NZ_LOWL.. - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 153,523 - 177,621 nt. (total: 24,099 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000648.1 |  | 0.33 | Terpene | carotenoid | Myxococcus xanthus
BGC0000647.1 |  | 0.32 | Terpene | carotenoid | Rhodobacter sphaeroides
BGC0000646.1 |  | 0.25 | Terpene | β-carotein | uncultured bacterium
BGC0000645.1 |  | 0.20 | Terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000495.1 |  | 0.17 | RiPP | actagardine | Actinoplanes garbadinensis
BGC0001586.1 |  | 0.16 | Saccharide | EPS273 | Pseudomonas stutzeri
BGC0001765.1 |  | 0.15 | Saccharide | salecan | Agrobacterium tumefaciens
BGC0001380.1 |  | 0.15 | Saccharide | salecan | Agrobacterium sp. ZX09
BGC0001374.1 |  | 0.15 | Other | thienodolin | Streptomyces albogriseolus
BGC0000874.1 |  | 0.15 | Other | blasticidin S | Streptomyces griseochromogenes

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000648.1 |  | 0.66 | Terpene | carotenoid | Myxococcus xanthus
BGC0000647.1 |  | 0.65 | Terpene | carotenoid | Rhodobacter sphaeroides
BGC0000646.1 |  | 0.58 | Terpene | β-carotein | uncultured bacterium
BGC0000645.1 |  | 0.53 | Terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000495.1 |  | 0.48 | RiPP | actagardine | Actinoplanes garbadinensis
BGC0001586.1 |  | 0.47 | Saccharide | EPS273 | Pseudomonas stutzeri
BGC0001765.1 |  | 0.45 | Saccharide | salecan | Agrobacterium tumefaciens
BGC0001380.1 |  | 0.45 | Saccharide | salecan | Agrobacterium sp. ZX09
BGC0001374.1 |  | 0.45 | Other | thienodolin | Streptomyces albogriseolus
BGC0000874.1 |  | 0.44 | Other | blasticidin S | Streptomyces griseochromogenes

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00038_NZ_LOWL.. - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 51,071 - 61,886 nt. (total: 10,816 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001882.1 |  | 0.18 | Polyketide | chrysoxanthone A, chrysoxanthone B, chrysoxanthone C | Penicillium rubens Wisconsin 54-1255
BGC0000145.1 |  | 0.04 | Polyketide | salinosporamide A | Salinispora tropica
BGC0000175.1 |  | 0.04 | Polyketide | cycloheximide | Streptomyces sp. YIM 56141
BGC0001041.1 |  | 0.04 | NRP, Polyketide | salinosporamide A | Salinispora tropica CNB-440
BGC0000446.1 |  | 0.04 | NRP | tilivalline, 9-deoxy tilivalline, dihydroxy tilivalline, dehydro tilivalline, dihydroxy-dehydro tilivalline | Klebsiella oxytoca
BGC0001805.1 |  | 0.04 | NRP | tilivalline | Klebsiella oxytoca
BGC0000148.1 |  | 0.03 | Polyketide | A83543A | Saccharopolyspora spinosa

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001882.1 |  | 0.50 | Polyketide | chrysoxanthone A, chrysoxanthone B, chrysoxanthone C | Penicillium rubens Wisconsin 54-1255
BGC0000145.1 |  | 0.21 | Polyketide | salinosporamide A | Salinispora tropica
BGC0000175.1 |  | 0.20 | Polyketide | cycloheximide | Streptomyces sp. YIM 56141
BGC0001041.1 |  | 0.18 | NRP, Polyketide | salinosporamide A | Salinispora tropica CNB-440
BGC0000446.1 |  | 0.17 | NRP | tilivalline, 9-deoxy tilivalline, dihydroxy tilivalline, dehydro tilivalline, dihydroxy-dehydro tilivalline | Klebsiella oxytoca
BGC0001805.1 |  | 0.17 | NRP | tilivalline | Klebsiella oxytoca
BGC0000148.1 |  | 0.16 | Polyketide | A83543A | Saccharopolyspora spinosa

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00042_NZ_LOWL.. - Region 1 - hserlactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 94,196 - 114,855 nt. (total: 20,660 nt) Show pHMM detection rules used
hserlactone: Autoind_synth

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | hserlactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001897.1 |  | 0.45 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0000888.1 |  | 0.26 | Other | bacilysin | Bacillus sp. CS93
BGC0001184.1 |  | 0.26 | Other | bacilysin | Bacillus velezensis FZB42
BGC0001444.1 |  | 0.21 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001521.1 |  | 0.21 | NRP | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0001197.1 |  | 0.20 | Polyketide | frankiamicin | Frankia sp. EAN1pec
BGC0000892.1 |  | 0.18 | Other | caryoynencin | Burkholderia gladioli BSR3
BGC0001241.1 |  | 0.17 | Terpene | ergotamine | Claviceps fusiformis
BGC0001267.1 |  | 0.17 | Terpene | lysergic acid, elymoclavine | Claviceps fusiformis
BGC0000679.1 |  | 0.17 | Terpene | diazepinomicin | Micromonospora sp. M42

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001897.1 |  | 0.75 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0000888.1 |  | 0.60 | Other | bacilysin | Bacillus sp. CS93
BGC0001184.1 |  | 0.60 | Other | bacilysin | Bacillus velezensis FZB42
BGC0001444.1 |  | 0.54 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001521.1 |  | 0.54 | NRP | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0001197.1 |  | 0.53 | Polyketide | frankiamicin | Frankia sp. EAN1pec
BGC0000892.1 |  | 0.49 | Other | caryoynencin | Burkholderia gladioli BSR3
BGC0001241.1 |  | 0.49 | Terpene | ergotamine | Claviceps fusiformis
BGC0001267.1 |  | 0.49 | Terpene | lysergic acid, elymoclavine | Claviceps fusiformis
BGC0000679.1 |  | 0.49 | Terpene | diazepinomicin | Micromonospora sp. M42

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00049_NZ_LOWL.. - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 34,446 - 89,196 nt. (total: 54,751 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001721.1 |  | 0.59 | NRP | ornibactin | Burkholderia cepacia
BGC0000426.1 |  | 0.36 | NRP | sevadicin | Paenibacillus larvae
BGC0000389.1 |  | 0.35 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001479.1 |  | 0.33 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000427.1 |  | 0.33 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001561.1 |  | 0.32 | NRP | curacomycin | Streptomyces curacoi
BGC0000348.1 |  | 0.31 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0000901.1 |  | 0.31 | Other | ferrichrome | Aspergillus niger
BGC0001261.1 |  | 0.31 | NRP | AM-toxin | Alternaria alternata
BGC0000900.1 |  | 0.31 | Other | ferrichrome | Aspergillus oryzae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001721.1 |  | 0.83 | NRP | ornibactin | Burkholderia cepacia
BGC0000426.1 |  | 0.69 | NRP | sevadicin | Paenibacillus larvae
BGC0000389.1 |  | 0.68 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001479.1 |  | 0.66 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000427.1 |  | 0.66 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001561.1 |  | 0.65 | NRP | curacomycin | Streptomyces curacoi
BGC0000348.1 |  | 0.64 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0000901.1 |  | 0.64 | Other | ferrichrome | Aspergillus niger
BGC0001261.1 |  | 0.64 | NRP | AM-toxin | Alternaria alternata
BGC0000900.1 |  | 0.64 | Other | ferrichrome | Aspergillus oryzae

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 34445 - 89196:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - D-asp - ser) + (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg49_50: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (517..923): X
  NRPSPredictor2: asp, asn, glu, gln, aad
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGeYTGgitK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      60% (weak)
ctg49_51: X - asp - ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (15..429): X
  NRPSPredictor2: asp, asn, glu, gln, aad
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAeAaGGisK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      60% (weak)
  AMP-binding (1101..1507): asp
  NRPSPredictor2: asp
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      asp, asn
    Single AA prediction:
      asp
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKVGHVGK
    Nearest Stachelhaus code:
      asp
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2634..3052): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHVSLIDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)

c00052_NZ_LOWL.. - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 95,116 - 116,021 nt. (total: 20,906 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000648.1 |  | 0.23 | Terpene | carotenoid | Myxococcus xanthus
BGC0000928.1 |  | 0.16 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.16 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0001456.1 |  | 0.14 | Terpene | isorenieratene | Streptomyces argillaceus
BGC0000633.1 |  | 0.14 | Terpene | carotenoid | Streptomyces avermitilis
BGC0000043.1 |  | 0.12 | Polyketide | curacin A | Moorea producens 19L
BGC0000545.1 |  | 0.09 | RiPP | ruminococcin A | [Ruminococcus] gnavus E1
BGC0001727.1 |  | 0.09 | RiPP | paenilan | Paenibacillus polymyxa E681
BGC0000897.1 |  | 0.09 | Other | dehydrophos | Streptomyces luridus
BGC0000842.1 |  | 0.09 | Other (Non-NRP beta-lactam) | carbapenem MM4550 | Streptomyces argenteolus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000648.1 |  | 0.56 | Terpene | carotenoid | Myxococcus xanthus
BGC0000928.1 |  | 0.47 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.47 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0001456.1 |  | 0.44 | Terpene | isorenieratene | Streptomyces argillaceus
BGC0000633.1 |  | 0.43 | Terpene | carotenoid | Streptomyces avermitilis
BGC0000043.1 |  | 0.39 | Polyketide | curacin A | Moorea producens 19L
BGC0000545.1 |  | 0.34 | RiPP | ruminococcin A | [Ruminococcus] gnavus E1
BGC0001727.1 |  | 0.34 | RiPP | paenilan | Paenibacillus polymyxa E681
BGC0000897.1 |  | 0.34 | Other | dehydrophos | Streptomyces luridus
BGC0000842.1 |  | 0.33 | Other (Non-NRP beta-lactam) | carbapenem MM4550 | Streptomyces argenteolus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names