GCF_000967305.2_ASM96730v2_genomic - 7 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP013119.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	ectoine	608,223	618,615	ectoine	Other	75%
Region 1.2	terpene	1,091,874	1,113,604	burkholderic acid	NRP + Polyketide:Modular type I	13%
Region 1.3	resorcinol,NRPS	1,974,123	2,050,563	bacillibactin	NRP:NRP siderophore	60%
Region 1.4	betalactone	2,088,912	2,115,321
Region 1.5	phosphonate	2,295,442	2,336,320
Region 1.6	T1PKS	2,696,181	2,740,098	emulsan	Saccharide	9%
Region 1.7	betalactone	3,851,748	3,882,936	quinolobactin	Other	26%

No secondary metabolite regions were found in these records:: NZ_CP013143.1

Compact view

NZ_CP013119.1 - Region 1 - ectoine

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Location: 608,223 - 618,615 nt. (total: 10,393 nt) Show pHMM detection rules used

ectoine: ectoine_synt

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000859.1	0.41	Other	ectoine	Methylomicrobium alcaliphilum
BGC0000853.1	0.41	Other	ectoine	Streptomyces anulatus
BGC0000856.1	0.41	Other	ectoine	Methylophaga thalassica
BGC0000852.1	0.39	Other	ectoine	Sporosarcina pasteurii
BGC0000857.1	0.36	Other	ectoine	Methylophaga alcalica
BGC0000855.1	0.34	Other	ectoine	Methylomicrobium kenyense
BGC0000858.1	0.33	Other	ectoine	Methylobacter marinus
BGC0000854.1	0.32	Other	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000860.1	0.23	Other	ectoine	Methylarcula marina
BGC0000703.1	0.14	Saccharide	kanamycin	Streptomyces kanamyceticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000859.1	0.72	Other	ectoine	Methylomicrobium alcaliphilum
BGC0000853.1	0.72	Other	ectoine	Streptomyces anulatus
BGC0000856.1	0.72	Other	ectoine	Methylophaga thalassica
BGC0000852.1	0.71	Other	ectoine	Sporosarcina pasteurii
BGC0000857.1	0.68	Other	ectoine	Methylophaga alcalica
BGC0000855.1	0.67	Other	ectoine	Methylomicrobium kenyense
BGC0000858.1	0.67	Other	ectoine	Methylobacter marinus
BGC0000854.1	0.66	Other	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000860.1	0.56	Other	ectoine	Methylarcula marina
BGC0000703.1	0.43	Saccharide	kanamycin	Streptomyces kanamyceticus

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Detailed TIGRFAM domain annotation

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NZ_CP013119.1 - Region 2 - terpene

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Location: 1,091,874 - 1,113,604 nt. (total: 21,731 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

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Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000647.1	0.33	Terpene	carotenoid	Rhodobacter sphaeroides
BGC0000646.1	0.24	Terpene	β-carotein	uncultured bacterium
BGC0000656.1	0.24	Terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000664.1	0.24	Terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000630.1	0.24	Terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000643.1	0.24	Terpene	carotenoid	Brevundimonas vesicularis
BGC0001227.1	0.24	Terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000634.1	0.24	Terpene	carotenoid	Brevundimonas sp. SD212
BGC0000633.1	0.24	Terpene	carotenoid	Streptomyces avermitilis
BGC0000640.1	0.23	Terpene	carotenoid	Enterobacteriaceae bacterium DC404

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000647.1	0.66	Terpene	carotenoid	Rhodobacter sphaeroides
BGC0000646.1	0.58	Terpene	β-carotein	uncultured bacterium
BGC0000656.1	0.57	Terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000664.1	0.57	Terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000630.1	0.57	Terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000643.1	0.57	Terpene	carotenoid	Brevundimonas vesicularis
BGC0001227.1	0.57	Terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000634.1	0.57	Terpene	carotenoid	Brevundimonas sp. SD212
BGC0000633.1	0.57	Terpene	carotenoid	Streptomyces avermitilis
BGC0000640.1	0.57	Terpene	carotenoid	Enterobacteriaceae bacterium DC404

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Detailed TIGRFAM domain annotation

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NZ_CP013119.1 - Region 3 - NRPS,resorcinol

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Location: 1,974,123 - 2,050,563 nt. (total: 76,441 nt) Show pHMM detection rules used

resorcinol: DarB
NRPS: cds(Condensation and (AMP-binding or A-OX))

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NRPS/PKS domains

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NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000513.1	0.38	RiPP	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0001940.1	0.34	Polyketide	pyxidicycline A, pyxidicycline B	Pyxidicoccus fallax
BGC0001343.1	0.34	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000225.1	0.33	Polyketide	frenolicin B	Streptomyces roseofulvus
BGC0000554.1	0.33	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001615.1	0.32	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0000487.1	0.32	RiPP	carnocyclin	Carnobacterium maltaromaticum
BGC0000519.1	0.32	RiPP	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0001407.1	0.32	RiPP	bicereucin	Bacillus cereus SJ1
BGC0001765.1	0.32	Saccharide	salecan	Agrobacterium tumefaciens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001615.1	0.66	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001302.1	0.60	Other	lomofungin	Streptomyces lomondensis
BGC0001132.1	0.57	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.1	0.57	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0000426.1	0.57	NRP	sevadicin	Paenibacillus larvae
BGC0000225.1	0.57	Polyketide	frenolicin B	Streptomyces roseofulvus
BGC0001128.1	0.57	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.1	0.57	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001825.1	0.57	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001964.1	0.56	Polyketide	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium

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Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 3, location 1974122 - 2050563:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ser)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 2006639 - 2050563:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_1824

Search NORINE for peptide: strict or relaxed

AMP-binding (34..442): dhb

NRPSPredictor2: dhb

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: pMPSQGVVNK
Nearest Stachelhaus code:: dhb
Stachelhaus code match:: 90% (moderate)

ctg1_1826

Search NORINE for peptide: strict or relaxed

AMP-binding (466..851): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLVDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

NZ_CP013119.1 - Region 4 - betalactone

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Location: 2,088,912 - 2,115,321 nt. (total: 26,410 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000938.1	0.21	Other (Aminocoumarin)	fosfomycin	Streptomyces fradiae
BGC0000544.1	0.16	RiPP	planosporicin	Planomonospora alba
BGC0000410.1	0.16	NRP	pseudomonine	Pseudomonas fluorescens
BGC0000537.1	0.16	RiPP	nisin U	Streptococcus uberis
BGC0001789.1	0.16	RiPP	suicin 90-1330	Streptococcus suis
BGC0000887.1	0.16	Alkaloid	saxitoxin, gonyautoxin 2, gonyautoxin 3, toxin C2, toxin C3, gonyautoxin 5, decarbamoylsaxitoxin, decarbamoylgonyautoxin 2, decarbamoylgonyautoxin 3	Dolichospermum circinale AWQC131C
BGC0000498.1	0.15	RiPP	bovicin HJ50	Streptococcus equinus
BGC0000561.1	0.15	RiPP	thermophilin 1277	Streptococcus thermophilus
BGC0000547.1	0.15	RiPP	salivaricin 9	Streptococcus salivarius
BGC0000634.1	0.15	Terpene	carotenoid	Brevundimonas sp. SD212

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000938.1	0.53	Other (Aminocoumarin)	fosfomycin	Streptomyces fradiae
BGC0000544.1	0.47	RiPP	planosporicin	Planomonospora alba
BGC0000410.1	0.46	NRP	pseudomonine	Pseudomonas fluorescens
BGC0000537.1	0.46	RiPP	nisin U	Streptococcus uberis
BGC0001789.1	0.46	RiPP	suicin 90-1330	Streptococcus suis
BGC0000887.1	0.46	Alkaloid	saxitoxin, gonyautoxin 2, gonyautoxin 3, toxin C2, toxin C3, gonyautoxin 5, decarbamoylsaxitoxin, decarbamoylgonyautoxin 2, decarbamoylgonyautoxin 3	Dolichospermum circinale AWQC131C
BGC0000498.1	0.46	RiPP	bovicin HJ50	Streptococcus equinus
BGC0000561.1	0.46	RiPP	thermophilin 1277	Streptococcus thermophilus
BGC0000547.1	0.46	RiPP	salivaricin 9	Streptococcus salivarius
BGC0000634.1	0.46	Terpene	carotenoid	Brevundimonas sp. SD212

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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NZ_CP013119.1 - Region 5 - phosphonate

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Location: 2,295,442 - 2,336,320 nt. (total: 40,879 nt) Show pHMM detection rules used

phosphonate: phosphonates

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KnownClusterBlast

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000897.1	0.36	Other	dehydrophos	Streptomyces luridus
BGC0001859.1	0.26	Other (Phosphonate)	fosfomycin	Pseudomonas syringae
BGC0001343.1	0.23	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000343.1	0.22	NRP	enterobactin	Pseudomonas sp. J465
BGC0000937.1	0.22	Other	fosfazinomycin A	Streptomyces sp. WM6372
BGC0002036.1	0.20	Other	dehydrofosmidomycin	Streptomyces lavendulae
BGC0000926.1	0.20	Other	rhizocticin A	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001739.1	0.20	Other	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0000874.1	0.19	Other	blasticidin S	Streptomyces griseochromogenes
BGC0001895.1	0.19	Polyketide	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000897.1	0.69	Other	dehydrophos	Streptomyces luridus
BGC0001859.1	0.59	Other (Phosphonate)	fosfomycin	Pseudomonas syringae
BGC0001343.1	0.56	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000343.1	0.55	NRP	enterobactin	Pseudomonas sp. J465
BGC0000937.1	0.55	Other	fosfazinomycin A	Streptomyces sp. WM6372
BGC0002036.1	0.53	Other	dehydrofosmidomycin	Streptomyces lavendulae
BGC0000926.1	0.53	Other	rhizocticin A	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001739.1	0.53	Other	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0000874.1	0.51	Other	blasticidin S	Streptomyces griseochromogenes
BGC0001895.1	0.51	Polyketide	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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NZ_CP013119.1 - Region 6 - T1PKS

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Location: 2,696,181 - 2,740,098 nt. (total: 43,918 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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Pfam domains

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Detailed domain annotation

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.31	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001749.1	0.31	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0001124.1	0.30	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0001340.1	0.30	Polyketide	byssochlamic acid	Byssochlamys fulva
BGC0000046.1	0.29	Polyketide	depudecin	Alternaria brassicicola
BGC0001067.1	0.28	Polyketide, Terpene	fumagillin, β-trans-bergamotene, fumagillol	Aspergillus fumigatus Af293
BGC0001913.1	0.28	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0001697.1	0.26	Polyketide	neurosporin A	Neurospora crassa OR74A
BGC0001141.1	0.23	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0001205.1	0.23	Polyketide	communesin A, communesin B, communesin C, communesin D, communesin E, communesin G, communesin H	Penicillium expansum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.65	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001749.1	0.64	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0001124.1	0.64	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0001340.1	0.63	Polyketide	byssochlamic acid	Byssochlamys fulva
BGC0000046.1	0.63	Polyketide	depudecin	Alternaria brassicicola
BGC0001067.1	0.61	Polyketide, Terpene	fumagillin, β-trans-bergamotene, fumagillol	Aspergillus fumigatus Af293
BGC0001913.1	0.61	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0001697.1	0.59	Polyketide	neurosporin A	Neurospora crassa OR74A
BGC0001141.1	0.57	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0001205.1	0.57	Polyketide	communesin A, communesin B, communesin C, communesin D, communesin E, communesin G, communesin H	Penicillium expansum

Similar known gene clusters

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Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 8, location 2696180 - 2740098:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_2456

PKS_AT (557..857): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 66.7%; Propionyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 99.4
Malonyl-CoA: 89.6
Methoxymalonyl-CoA: 78.9
Ethylmalonyl-CoA: 62.0
Propionyl-CoA: 51.1
Isobutyryl-CoA: 49.4
2-Methylbutyryl-CoA: 40.5
trans-1,2-CPDA: 34.5
CHC-CoA: 31.7
fatty_acid: 22.1
Acetyl-CoA: 21.8
inactive: 21.7
Benzoyl-CoA: 20.1
3-Methylbutyryl-CoA: 15.2

NZ_CP013119.1 - Region 7 - betalactone

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Location: 3,851,748 - 3,882,936 nt. (total: 31,189 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001441.1	0.34	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0000585.1	0.21	RiPP	microcin C7	Escherichia coli
BGC0000343.1	0.20	NRP	enterobactin	Pseudomonas sp. J465
BGC0001444.1	0.19	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.19	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001831.1	0.19	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0000469.1	0.18	RiPP	bottromycin A2	Streptomyces sp. BC16019
BGC0000774.1	0.17	Saccharide	lipopolysaccharide	Xanthomonas campestris pv. campestris
BGC0000917.1	0.17	Other	molybdenum cofactor	Rhodobacter capsulatus
BGC0001440.1	0.17	Other	cystargolide A, cystargolide B	Kitasatospora cystarginea

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001441.1	0.67	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0000585.1	0.54	RiPP	microcin C7	Escherichia coli
BGC0000343.1	0.53	NRP	enterobactin	Pseudomonas sp. J465
BGC0001444.1	0.51	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.51	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001831.1	0.51	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0000469.1	0.50	RiPP	bottromycin A2	Streptomyces sp. BC16019
BGC0000774.1	0.49	Saccharide	lipopolysaccharide	Xanthomonas campestris pv. campestris
BGC0000917.1	0.48	Other	molybdenum cofactor	Rhodobacter capsulatus
BGC0001440.1	0.48	Other	cystargolide A, cystargolide B	Kitasatospora cystarginea

Similar known gene clusters

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

Selected features only

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