GCF_000191145.1_ASM19114v1_genomic - 7 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NC_016603.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	arylpolyene	113,999	153,057	berninamycin A	RiPP	26%
Region 2	RiPP-like	615,540	626,403
Region 3	betalactone	782,859	811,938	mycosubtilin	NRP + Polyketide	20%
Region 4	redox-cofactor	1,169,694	1,191,884	lankacidin C	NRP + Polyketide	13%
Region 5	siderophore	1,599,829	1,616,256	staphylobactin	Other	12%
Region 6	NRPS,hserlactone	3,246,015	3,289,974
Region 7	arylpolyene	3,666,921	3,710,523	APE Vf	Other	45%

NC_016603.1 - Region 1 - arylpolyene

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Location: 113,999 - 153,057 nt. (total: 39,059 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

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Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000779.1	0.22	Saccharide	lipopolysaccharide	Aeromonas piscicola
BGC0000780.1	0.19	Saccharide	O&K-antigen	Vibrio parahaemolyticus
BGC0002008.1	0.17	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0001897.1	0.17	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0001739.1	0.16	Other	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0001343.1	0.16	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000836.1	0.16	Other	APE Ec	Escherichia coli CFT073
BGC0001120.1	0.15	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0000275.1	0.14	Polyketide	tetracenomycin C	Streptomyces glaucescens
BGC0001366.1	0.14	Polyketide	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000779.1	0.54	Saccharide	lipopolysaccharide	Aeromonas piscicola
BGC0000780.1	0.51	Saccharide	O&K-antigen	Vibrio parahaemolyticus
BGC0002008.1	0.48	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0001897.1	0.48	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0001739.1	0.47	Other	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0001343.1	0.47	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000836.1	0.46	Other	APE Ec	Escherichia coli CFT073
BGC0001120.1	0.45	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0000275.1	0.44	Polyketide	tetracenomycin C	Streptomyces glaucescens
BGC0001366.1	0.44	Polyketide	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2

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NC_016603.1 - Region 2 - RiPP-like

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Location: 615,540 - 626,403 nt. (total: 10,864 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

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Analysis type:

No matches found.

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

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NC_016603.1 - Region 3 - betalactone

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Location: 782,859 - 811,938 nt. (total: 29,080 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000662.1	0.24	Terpene	grixazone	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000258.1	0.20	Polyketide	prodigiosin	Serratia sp.
BGC0001897.1	0.20	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0000259.1	0.20	Polyketide	prodigiosin	Serratia marcescens
BGC0000890.1	0.20	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas phenolica O-BC30
BGC0000234.1	0.20	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000891.1	0.20	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas luteoviolacea 2ta16
BGC0001940.1	0.17	Polyketide	pyxidicycline A, pyxidicycline B	Pyxidicoccus fallax
BGC0001983.1	0.17	Other	triacsins	Kitasatospora aureofaciens
BGC0000373.1	0.16	NRP	holomycin	Streptomyces clavuligerus ATCC 27064

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000662.1	0.58	Terpene	grixazone	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000258.1	0.53	Polyketide	prodigiosin	Serratia sp.
BGC0001897.1	0.52	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0000259.1	0.52	Polyketide	prodigiosin	Serratia marcescens
BGC0000890.1	0.52	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas phenolica O-BC30
BGC0000234.1	0.52	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000891.1	0.52	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas luteoviolacea 2ta16
BGC0001940.1	0.48	Polyketide	pyxidicycline A, pyxidicycline B	Pyxidicoccus fallax
BGC0001983.1	0.48	Other	triacsins	Kitasatospora aureofaciens
BGC0000373.1	0.47	NRP	holomycin	Streptomyces clavuligerus ATCC 27064

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NC_016603.1 - Region 4 - redox-cofactor

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Location: 1,169,694 - 1,191,884 nt. (total: 22,191 nt) Show pHMM detection rules used

redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

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KnownClusterBlast

Pfam domains

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Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001733.1	0.25	RiPP	PcpA	Pleurocapsa sp. PCC 7327
BGC0001645.1	0.22	RiPP	lagmysin	Streptomyces sp. NRRL S-118
BGC0000575.1	0.20	RiPP	lariatin	Rhodococcus jostii
BGC0001496.1	0.20	RiPP	actinokineosin	Actinokineospora spheciospongiae
BGC0001889.1	0.20	RiPP	fusilassin	Thermobifida fusca YX
BGC0001549.1	0.19	RiPP	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0001176.1	0.19	RiPP	streptomonomicin	Streptomonospora alba
BGC0001550.1	0.19	RiPP	citrulassin D	Streptomyces katrae
BGC0001552.1	0.19	RiPP	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001551.1	0.19	RiPP	citrulassin E	Streptomyces glaucescens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001733.1	0.59	RiPP	PcpA	Pleurocapsa sp. PCC 7327
BGC0001645.1	0.55	RiPP	lagmysin	Streptomyces sp. NRRL S-118
BGC0000575.1	0.52	RiPP	lariatin	Rhodococcus jostii
BGC0001496.1	0.52	RiPP	actinokineosin	Actinokineospora spheciospongiae
BGC0001889.1	0.52	RiPP	fusilassin	Thermobifida fusca YX
BGC0001549.1	0.52	RiPP	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0001176.1	0.52	RiPP	streptomonomicin	Streptomonospora alba
BGC0001550.1	0.51	RiPP	citrulassin D	Streptomyces katrae
BGC0001552.1	0.51	RiPP	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001551.1	0.51	RiPP	citrulassin E	Streptomyces glaucescens

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Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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NC_016603.1 - Region 5 - siderophore

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Location: 1,599,829 - 1,616,256 nt. (total: 16,428 nt) Show pHMM detection rules used

siderophore: IucA_IucC

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Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001572.1	0.31	Other	desferrioxamine E	Pantoea agglomerans
BGC0000295.1	0.30	NRP	acinetoferrin	Acinetobacter haemolyticus
BGC0001453.1	0.27	Other	desferrioxamine	Streptomyces argillaceus
BGC0000942.1	0.27	Other	petrobactin	Bacillus anthracis str. Ames
BGC0000939.1	0.19	Other	aerobactin	Grimontia hollisae
BGC0000946.1	0.19	Other	vibrioferrin	Vibrio parahaemolyticus
BGC0000943.1	0.17	Other	staphylobactin	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000947.1	0.16	Other	vibrioferrin	Vibrio alginolyticus
BGC0000896.1	0.14	Other	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0000774.1	0.14	Saccharide	lipopolysaccharide	Xanthomonas campestris pv. campestris

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001572.1	0.64	Other	desferrioxamine E	Pantoea agglomerans
BGC0000295.1	0.63	NRP	acinetoferrin	Acinetobacter haemolyticus
BGC0001453.1	0.61	Other	desferrioxamine	Streptomyces argillaceus
BGC0000942.1	0.61	Other	petrobactin	Bacillus anthracis str. Ames
BGC0000939.1	0.51	Other	aerobactin	Grimontia hollisae
BGC0000946.1	0.50	Other	vibrioferrin	Vibrio parahaemolyticus
BGC0000943.1	0.48	Other	staphylobactin	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000947.1	0.47	Other	vibrioferrin	Vibrio alginolyticus
BGC0000896.1	0.44	Other	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0000774.1	0.44	Saccharide	lipopolysaccharide	Xanthomonas campestris pv. campestris

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Detailed TIGRFAM domain annotation

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NC_016603.1 - Region 6 - NRPS,hserlactone

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Location: 3,246,015 - 3,289,974 nt. (total: 43,960 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))
hserlactone: Autoind_synth

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NRPS/PKS domains

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NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

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Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000343.1	0.59	NRP	enterobactin	Pseudomonas sp. J465
BGC0001343.1	0.52	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0001983.1	0.51	Other	triacsins	Kitasatospora aureofaciens
BGC0001831.1	0.47	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0000220.1	0.46	Polyketide	enterocin	Streptomyces maritimus
BGC0001458.1	0.42	Other (Aminocoumarin)	salinipostin G	Salinispora tropica CNB-440
BGC0000274.1	0.41	Polyketide	tetarimycin A, tetarimycin B	uncultured bacterium
BGC0002034.1	0.41	Other	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6
BGC0000246.1	0.40	Polyketide	mithramycin	Streptomyces argillaceus
BGC0001185.1	0.40	NRP	bacillibactin	Bacillus velezensis FZB42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000343.1	0.68	NRP	enterobactin	Pseudomonas sp. J465
BGC0001890.1	0.65	NRP	amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4	Vibrio campbellii ATCC BAA-1116
BGC0001615.1	0.65	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001343.1	0.62	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000426.1	0.62	NRP	sevadicin	Paenibacillus larvae
BGC0001778.1	0.61	Other	showdomycin	Streptomyces showdoensis
BGC0001983.1	0.61	Other	triacsins	Kitasatospora aureofaciens
BGC0000389.1	0.60	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000417.1	0.59	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0002034.1	0.58	Other	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 6, location 3246014 - 3289974:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (gly)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_3017

Search NORINE for peptide: strict or relaxed

AMP-binding (38..363): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: ayyaSAHmVK
Nearest Stachelhaus code:: pip
Stachelhaus code match:: 50% (weak)

ctg1_3026

CAL_domain (162..486): pk

minowa: NH2

Prediction, score:

NH2: 118.0
Acetyl-CoA: 57.4
fatty_acid: 20.6
shikimic_acid: 0.0
AHBA: 0.0

ctg1_3029

Search NORINE for peptide: strict or relaxed

AMP-binding (487..872): gly

NRPSPredictor2: gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: gly

Stachelhaus prediction details:

Stachelhaus sequence:: DIvQLGVvWK
Nearest Stachelhaus code:: gly
Stachelhaus code match:: 80% (moderate)

NC_016603.1 - Region 7 - arylpolyene

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Location: 3,666,921 - 3,710,523 nt. (total: 43,603 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

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KnownClusterBlast

Pfam domains

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002008.1	0.30	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.1	0.28	Other	APE Ec	Escherichia coli CFT073
BGC0000231.1	0.24	Polyketide	griseusin	Streptomyces griseus
BGC0001723.1	0.24	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0001591.1	0.23	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.23	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000219.1	0.22	Polyketide, Saccharide	elloramycin	Streptomyces olivaceus
BGC0000234.1	0.22	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000228.1	0.22	Polyketide	granaticin	Streptomyces violaceoruber
BGC0001366.1	0.22	Polyketide	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002008.1	0.63	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.1	0.61	Other	APE Ec	Escherichia coli CFT073
BGC0000231.1	0.57	Polyketide	griseusin	Streptomyces griseus
BGC0001723.1	0.57	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0001591.1	0.56	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.56	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000219.1	0.56	Polyketide, Saccharide	elloramycin	Streptomyces olivaceus
BGC0000234.1	0.55	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000228.1	0.55	Polyketide	granaticin	Streptomyces violaceoruber
BGC0001366.1	0.54	Polyketide	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2

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Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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