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Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7

### Identified secondary metabolite regions using strictness 'relaxed'

NC_016603.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | arylpolyene | 113,999 | 153,057 | berninamycin A | RiPP | 26%
Region 2 | RiPP-like | 615,540 | 626,403 |
Region 3 | betalactone | 782,859 | 811,938 | mycosubtilin | NRP + Polyketide | 20%
Region 4 | redox-cofactor | 1,169,694 | 1,191,884 | lankacidin C | NRP + Polyketide | 13%
Region 5 | siderophore | 1,599,829 | 1,616,256 | staphylobactin | Other | 12%
Region 6 | NRPS,hserlactone | 3,246,015 | 3,289,974 |
Region 7 | arylpolyene | 3,666,921 | 3,710,523 | APE Vf | Other | 45%

NC_016603.1 - Region 1 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 113,999 - 153,057 nt. (total: 39,059 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000779.1 |  | 0.22 | Saccharide | lipopolysaccharide | Aeromonas piscicola
BGC0000780.1 |  | 0.19 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0002008.1 |  | 0.17 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0001897.1 |  | 0.17 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001739.1 |  | 0.16 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0001343.1 |  | 0.16 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000836.1 |  | 0.16 | Other | APE Ec | Escherichia coli CFT073
BGC0001120.1 |  | 0.15 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000275.1 |  | 0.14 | Polyketide | tetracenomycin C | Streptomyces glaucescens
BGC0001366.1 |  | 0.14 | Polyketide | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000779.1 |  | 0.54 | Saccharide | lipopolysaccharide | Aeromonas piscicola
BGC0000780.1 |  | 0.51 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0002008.1 |  | 0.48 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0001897.1 |  | 0.48 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001739.1 |  | 0.47 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0001343.1 |  | 0.47 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000836.1 |  | 0.46 | Other | APE Ec | Escherichia coli CFT073
BGC0001120.1 |  | 0.45 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000275.1 |  | 0.44 | Polyketide | tetracenomycin C | Streptomyces glaucescens
BGC0001366.1 |  | 0.44 | Polyketide | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_016603.1 - Region 2 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 615,540 - 626,403 nt. (total: 10,864 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

No matches found.

No matches found.

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_016603.1 - Region 3 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 782,859 - 811,938 nt. (total: 29,080 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000662.1 |  | 0.24 | Terpene | grixazone | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000258.1 |  | 0.20 | Polyketide | prodigiosin | Serratia sp.
BGC0001897.1 |  | 0.20 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0000259.1 |  | 0.20 | Polyketide | prodigiosin | Serratia marcescens
BGC0000890.1 |  | 0.20 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas phenolica O-BC30
BGC0000234.1 |  | 0.20 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000891.1 |  | 0.20 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas luteoviolacea 2ta16
BGC0001940.1 |  | 0.17 | Polyketide | pyxidicycline A, pyxidicycline B | Pyxidicoccus fallax
BGC0001983.1 |  | 0.17 | Other | triacsins | Kitasatospora aureofaciens
BGC0000373.1 |  | 0.16 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000662.1 |  | 0.58 | Terpene | grixazone | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000258.1 |  | 0.53 | Polyketide | prodigiosin | Serratia sp.
BGC0001897.1 |  | 0.52 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0000259.1 |  | 0.52 | Polyketide | prodigiosin | Serratia marcescens
BGC0000890.1 |  | 0.52 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas phenolica O-BC30
BGC0000234.1 |  | 0.52 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000891.1 |  | 0.52 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas luteoviolacea 2ta16
BGC0001940.1 |  | 0.48 | Polyketide | pyxidicycline A, pyxidicycline B | Pyxidicoccus fallax
BGC0001983.1 |  | 0.48 | Other | triacsins | Kitasatospora aureofaciens
BGC0000373.1 |  | 0.47 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_016603.1 - Region 4 - redox-cofactor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,169,694 - 1,191,884 nt. (total: 22,191 nt) Show pHMM detection rules used
redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | redox-cofactor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001733.1 |  | 0.25 | RiPP | PcpA | Pleurocapsa sp. PCC 7327
BGC0001645.1 |  | 0.22 | RiPP | lagmysin | Streptomyces sp. NRRL S-118
BGC0000575.1 |  | 0.20 | RiPP | lariatin | Rhodococcus jostii
BGC0001496.1 |  | 0.20 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0001889.1 |  | 0.20 | RiPP | fusilassin | Thermobifida fusca YX
BGC0001549.1 |  | 0.19 | RiPP | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0001176.1 |  | 0.19 | RiPP | streptomonomicin | Streptomonospora alba
BGC0001550.1 |  | 0.19 | RiPP | citrulassin D | Streptomyces katrae
BGC0001552.1 |  | 0.19 | RiPP | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001551.1 |  | 0.19 | RiPP | citrulassin E | Streptomyces glaucescens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001733.1 |  | 0.59 | RiPP | PcpA | Pleurocapsa sp. PCC 7327
BGC0001645.1 |  | 0.55 | RiPP | lagmysin | Streptomyces sp. NRRL S-118
BGC0000575.1 |  | 0.52 | RiPP | lariatin | Rhodococcus jostii
BGC0001496.1 |  | 0.52 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0001889.1 |  | 0.52 | RiPP | fusilassin | Thermobifida fusca YX
BGC0001549.1 |  | 0.52 | RiPP | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0001176.1 |  | 0.52 | RiPP | streptomonomicin | Streptomonospora alba
BGC0001550.1 |  | 0.51 | RiPP | citrulassin D | Streptomyces katrae
BGC0001552.1 |  | 0.51 | RiPP | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001551.1 |  | 0.51 | RiPP | citrulassin E | Streptomyces glaucescens

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_016603.1 - Region 5 - siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,599,829 - 1,616,256 nt. (total: 16,428 nt) Show pHMM detection rules used
siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001572.1 |  | 0.31 | Other | desferrioxamine E | Pantoea agglomerans
BGC0000295.1 |  | 0.30 | NRP | acinetoferrin | Acinetobacter haemolyticus
BGC0001453.1 |  | 0.27 | Other | desferrioxamine | Streptomyces argillaceus
BGC0000942.1 |  | 0.27 | Other | petrobactin | Bacillus anthracis str. Ames
BGC0000939.1 |  | 0.19 | Other | aerobactin | Grimontia hollisae
BGC0000946.1 |  | 0.19 | Other | vibrioferrin | Vibrio parahaemolyticus
BGC0000943.1 |  | 0.17 | Other | staphylobactin | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000947.1 |  | 0.16 | Other | vibrioferrin | Vibrio alginolyticus
BGC0000896.1 |  | 0.14 | Other | cycloserine | Streptomyces lavendulae subsp. lavendulae
BGC0000774.1 |  | 0.14 | Saccharide | lipopolysaccharide | Xanthomonas campestris pv. campestris

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001572.1 |  | 0.64 | Other | desferrioxamine E | Pantoea agglomerans
BGC0000295.1 |  | 0.63 | NRP | acinetoferrin | Acinetobacter haemolyticus
BGC0001453.1 |  | 0.61 | Other | desferrioxamine | Streptomyces argillaceus
BGC0000942.1 |  | 0.61 | Other | petrobactin | Bacillus anthracis str. Ames
BGC0000939.1 |  | 0.51 | Other | aerobactin | Grimontia hollisae
BGC0000946.1 |  | 0.50 | Other | vibrioferrin | Vibrio parahaemolyticus
BGC0000943.1 |  | 0.48 | Other | staphylobactin | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000947.1 |  | 0.47 | Other | vibrioferrin | Vibrio alginolyticus
BGC0000896.1 |  | 0.44 | Other | cycloserine | Streptomyces lavendulae subsp. lavendulae
BGC0000774.1 |  | 0.44 | Saccharide | lipopolysaccharide | Xanthomonas campestris pv. campestris

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_016603.1 - Region 6 - NRPS,hserlactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,246,015 - 3,289,974 nt. (total: 43,960 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))
hserlactone: Autoind_synth

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | hserlactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000343.1 |  |  | 0.59 | NRP | enterobactin | Pseudomonas sp. J465
BGC0001343.1 |  |  | 0.52 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001983.1 |  |  | 0.51 | Other | triacsins | Kitasatospora aureofaciens
BGC0001831.1 |  |  | 0.47 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0000220.1 |  |  | 0.46 | Polyketide | enterocin | Streptomyces maritimus
BGC0001458.1 |  |  | 0.42 | Other (Aminocoumarin) | salinipostin G | Salinispora tropica CNB-440
BGC0000274.1 |  |  | 0.41 | Polyketide | tetarimycin A, tetarimycin B | uncultured bacterium
BGC0002034.1 |  |  | 0.41 | Other | perquinoline A, perquinoline B, perquinoline C | Streptomyces sp. IB2014 016-6
BGC0000246.1 |  |  | 0.40 | Polyketide | mithramycin | Streptomyces argillaceus
BGC0001185.1 |  |  | 0.40 | NRP | bacillibactin | Bacillus velezensis FZB42

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000343.1 |  | 0.68 | NRP | enterobactin | Pseudomonas sp. J465
BGC0001890.1 |  | 0.65 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116
BGC0001615.1 |  | 0.65 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001343.1 |  | 0.62 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000426.1 |  | 0.62 | NRP | sevadicin | Paenibacillus larvae
BGC0001778.1 |  | 0.61 | Other | showdomycin | Streptomyces showdoensis
BGC0001983.1 |  | 0.61 | Other | triacsins | Kitasatospora aureofaciens
BGC0000389.1 |  | 0.60 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000417.1 |  | 0.59 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0002034.1 |  | 0.58 | Other | perquinoline A, perquinoline B, perquinoline C | Streptomyces sp. IB2014 016-6

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 6, location 3246014 - 3289974:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (gly)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_3017: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (38..363): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      ayyaSAHmVK
    Nearest Stachelhaus code:
      pip
    Stachelhaus code match:
      50% (weak)
ctg1_3026: pk
  CAL_domain (162..486): pk
  minowa: NH2
  Prediction, score:
    NH2: 118.0
    Acetyl-CoA: 57.4
    fatty_acid: 20.6
    shikimic_acid: 0.0
    AHBA: 0.0
ctg1_3029: gly
  Search NORINE for peptide: strict or relaxed
  AMP-binding (487..872): gly
  NRPSPredictor2: gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      gly
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DIvQLGVvWK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      80% (moderate)

NC_016603.1 - Region 7 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,666,921 - 3,710,523 nt. (total: 43,603 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002008.1 |  | 0.30 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0000836.1 |  | 0.28 | Other | APE Ec | Escherichia coli CFT073
BGC0000231.1 |  | 0.24 | Polyketide | griseusin | Streptomyces griseus
BGC0001723.1 |  | 0.24 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0001591.1 |  | 0.23 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.23 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000219.1 |  | 0.22 | Polyketide, Saccharide | elloramycin | Streptomyces olivaceus
BGC0000234.1 |  | 0.22 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000228.1 |  | 0.22 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0001366.1 |  | 0.22 | Polyketide | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002008.1 |  | 0.63 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0000836.1 |  | 0.61 | Other | APE Ec | Escherichia coli CFT073
BGC0000231.1 |  | 0.57 | Polyketide | griseusin | Streptomyces griseus
BGC0001723.1 |  | 0.57 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0001591.1 |  | 0.56 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.56 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000219.1 |  | 0.56 | Polyketide, Saccharide | elloramycin | Streptomyces olivaceus
BGC0000234.1 |  | 0.55 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000228.1 |  | 0.55 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0001366.1 |  | 0.54 | Polyketide | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names