GCF_008632635.1_ASM863263v1_genomic - 6 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP043953.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	NAPAA	917,621	951,619
Region 1.2	redox-cofactor	1,970,990	1,993,180	lankacidin C	NRP + Polyketide	13%
Region 1.3	siderophore	2,103,171	2,121,614	acinetoferrin	NRP	30%
Region 1.4	betalactone	2,370,059	2,399,140	mycosubtilin	NRP + Polyketide	20%
Region 1.5	arylpolyene	3,074,939	3,115,456	berninamycin A	RiPP	26%
Region 1.6	NRPS,hserlactone,arylpolyene	3,801,003	3,877,984

Region	Type	From	To	Most similar known cluster	Similarity
Region 1.1	NAPAA	917,621	951,619
Region 1.2	redox-cofactor	1,970,990	1,993,180	lankacidin C	NRP + Polyketide	13%
Region 1.3	siderophore	2,103,171	2,121,614	acinetoferrin	NRP	30%
Region 1.4	betalactone	2,370,059	2,399,140	mycosubtilin	NRP + Polyketide	20%
Region 1.5	arylpolyene	3,074,939	3,115,456	berninamycin A	RiPP	26%
Region 1.6	NRPS,hserlactone,arylpolyene	3,801,003	3,877,984

No secondary metabolite regions were found in these records:: NZ_CP043954.1

Compact view

NZ_CP043953.1 - Region 1 - NAPAA

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Location: 917,621 - 951,619 nt. (total: 33,999 nt) Show pHMM detection rules used

NAPAA: (AMP-binding and PP-binding and TIGR02353)

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core biosynthetic genes

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000427.1	0.22	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001135.1	0.18	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001641.1	0.18	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001479.1	0.18	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001758.1	0.18	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000375.1	0.18	NRP	indigoidine	Streptomyces chromofuscus
BGC0001833.1	0.18	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001844.1	0.18	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001128.1	0.18	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001615.1	0.18	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000427.1	0.54	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001135.1	0.50	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001641.1	0.50	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001479.1	0.50	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001758.1	0.50	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000375.1	0.50	NRP	indigoidine	Streptomyces chromofuscus
BGC0001833.1	0.50	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001844.1	0.50	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001128.1	0.49	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001615.1	0.49	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10

Similar known gene clusters

No matches found.

Module view

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 917620 - 951619:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_833

Search NORINE for peptide: strict or relaxed

AMP-binding (29..418): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DmEHNgTVSK
Nearest Stachelhaus code:: dab
Stachelhaus code match:: 80% (moderate)

NZ_CP043953.1 - Region 2 - redox-cofactor

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Location: 1,970,990 - 1,993,180 nt. (total: 22,191 nt) Show pHMM detection rules used

redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

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core biosynthetic genes

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001645.1	0.22	RiPP	lagmysin	Streptomyces sp. NRRL S-118
BGC0001176.1	0.20	RiPP	streptomonomicin	Streptomonospora alba
BGC0000575.1	0.20	RiPP	lariatin	Rhodococcus jostii
BGC0001496.1	0.20	RiPP	actinokineosin	Actinokineospora spheciospongiae
BGC0001889.1	0.20	RiPP	fusilassin	Thermobifida fusca YX
BGC0001549.1	0.19	RiPP	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0001550.1	0.19	RiPP	citrulassin D	Streptomyces katrae
BGC0001552.1	0.19	RiPP	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001551.1	0.19	RiPP	citrulassin E	Streptomyces glaucescens
BGC0001634.1	0.19	RiPP	keywimysin	Streptomyces sp. NRRL F-5702

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001645.1	0.55	RiPP	lagmysin	Streptomyces sp. NRRL S-118
BGC0001176.1	0.52	RiPP	streptomonomicin	Streptomonospora alba
BGC0000575.1	0.52	RiPP	lariatin	Rhodococcus jostii
BGC0001496.1	0.52	RiPP	actinokineosin	Actinokineospora spheciospongiae
BGC0001889.1	0.52	RiPP	fusilassin	Thermobifida fusca YX
BGC0001549.1	0.52	RiPP	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0001550.1	0.51	RiPP	citrulassin D	Streptomyces katrae
BGC0001552.1	0.51	RiPP	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001551.1	0.51	RiPP	citrulassin E	Streptomyces glaucescens
BGC0001634.1	0.51	RiPP	keywimysin	Streptomyces sp. NRRL F-5702

Similar known gene clusters

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_CP043953.1 - Region 3 - siderophore

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Location: 2,103,171 - 2,121,614 nt. (total: 18,444 nt) Show pHMM detection rules used

siderophore: IucA_IucC

Legend:

core biosynthetic genes

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transport-related genes

regulatory genes

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resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001478.1	0.31	Other	desferrioxamine E	Streptomyces sp. ID38640
BGC0000942.1	0.28	Other	petrobactin	Bacillus anthracis str. Ames
BGC0001572.1	0.27	Other	desferrioxamine E	Pantoea agglomerans
BGC0000295.1	0.23	NRP	acinetoferrin	Acinetobacter haemolyticus
BGC0001499.1	0.22	Other	aerobactin	Pantoea ananatis
BGC0000941.1	0.22	Other	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001453.1	0.21	Other	desferrioxamine	Streptomyces argillaceus
BGC0000940.1	0.21	Other	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001531.1	0.21	Other	bisucaberin B	Tenacibaculum mesophilum
BGC0001870.1	0.20	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001478.1	0.64	Other	desferrioxamine E	Streptomyces sp. ID38640
BGC0000942.1	0.61	Other	petrobactin	Bacillus anthracis str. Ames
BGC0001572.1	0.60	Other	desferrioxamine E	Pantoea agglomerans
BGC0000295.1	0.57	NRP	acinetoferrin	Acinetobacter haemolyticus
BGC0001499.1	0.55	Other	aerobactin	Pantoea ananatis
BGC0000941.1	0.54	Other	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001453.1	0.54	Other	desferrioxamine	Streptomyces argillaceus
BGC0000940.1	0.54	Other	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001531.1	0.54	Other	bisucaberin B	Tenacibaculum mesophilum
BGC0001870.1	0.52	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis

Similar known gene clusters

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_CP043953.1 - Region 4 - betalactone

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Location: 2,370,059 - 2,399,140 nt. (total: 29,082 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

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core biosynthetic genes

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000234.1	0.21	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000258.1	0.21	Polyketide	prodigiosin	Serratia sp.
BGC0001897.1	0.20	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0000259.1	0.20	Polyketide	prodigiosin	Serratia marcescens
BGC0000890.1	0.20	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas phenolica O-BC30
BGC0000891.1	0.20	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas luteoviolacea 2ta16
BGC0001983.1	0.17	Other	triacsins	Kitasatospora aureofaciens
BGC0000373.1	0.16	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0001940.1	0.16	Polyketide	pyxidicycline A, pyxidicycline B	Pyxidicoccus fallax
BGC0001730.1	0.15	Polyketide	paramagnetoquinone 1, paramagnetoquinone 2	Actinoallomurus sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000234.1	0.54	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000258.1	0.53	Polyketide	prodigiosin	Serratia sp.
BGC0001897.1	0.52	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0000259.1	0.52	Polyketide	prodigiosin	Serratia marcescens
BGC0000890.1	0.52	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas phenolica O-BC30
BGC0000891.1	0.52	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas luteoviolacea 2ta16
BGC0001983.1	0.48	Other	triacsins	Kitasatospora aureofaciens
BGC0000373.1	0.47	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0001940.1	0.46	Polyketide	pyxidicycline A, pyxidicycline B	Pyxidicoccus fallax
BGC0001730.1	0.45	Polyketide	paramagnetoquinone 1, paramagnetoquinone 2	Actinoallomurus sp.

Similar known gene clusters

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_CP043953.1 - Region 5 - arylpolyene

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Location: 3,074,939 - 3,115,456 nt. (total: 40,518 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

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transport-related genes

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000779.1	0.22	Saccharide	lipopolysaccharide	Aeromonas piscicola
BGC0000780.1	0.19	Saccharide	O&K-antigen	Vibrio parahaemolyticus
BGC0002008.1	0.17	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0001343.1	0.17	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000836.1	0.17	Other	APE Ec	Escherichia coli CFT073
BGC0001897.1	0.17	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0001739.1	0.16	Other	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0001120.1	0.15	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0001917.1	0.15	Polyketide	5-alkyl-1,2,3,4-tetrahydroquinolines, streptoaminals	Streptomyces nigrescens
BGC0001366.1	0.14	Polyketide	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000779.1	0.54	Saccharide	lipopolysaccharide	Aeromonas piscicola
BGC0000780.1	0.51	Saccharide	O&K-antigen	Vibrio parahaemolyticus
BGC0002008.1	0.48	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0001343.1	0.48	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000836.1	0.48	Other	APE Ec	Escherichia coli CFT073
BGC0001897.1	0.48	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0001739.1	0.47	Other	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0001120.1	0.45	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0001917.1	0.45	Polyketide	5-alkyl-1,2,3,4-tetrahydroquinolines, streptoaminals	Streptomyces nigrescens
BGC0001366.1	0.44	Polyketide	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2

Similar known gene clusters

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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NZ_CP043953.1 - Region 6 - NRPS,arylpolyene,hserlactone

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Location: 3,801,003 - 3,877,984 nt. (total: 76,982 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))
hserlactone: Autoind_synth
arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001947.1	0.83	Saccharide	K53 capsular polysaccharide	Acinetobacter baumannii
BGC0001983.1	0.63	Other	triacsins	Kitasatospora aureofaciens
BGC0001343.1	0.62	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000343.1	0.58	NRP	enterobactin	Pseudomonas sp. J465
BGC0000220.1	0.54	Polyketide	enterocin	Streptomyces maritimus
BGC0000246.1	0.52	Polyketide	mithramycin	Streptomyces argillaceus
BGC0000274.1	0.52	Polyketide	tetarimycin A, tetarimycin B	uncultured bacterium
BGC0000313.1	0.49	NRP	beauvericin	Beauveria bassiana
BGC0001739.1	0.49	Other	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0001897.1	0.48	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001947.1	0.94	Saccharide	K53 capsular polysaccharide	Acinetobacter baumannii
BGC0001890.1	0.65	NRP	amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4	Vibrio campbellii ATCC BAA-1116
BGC0001615.1	0.65	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001399.1	0.64	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001778.1	0.61	Other	showdomycin	Streptomyces showdoensis
BGC0000417.1	0.60	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000389.1	0.60	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000255.1	0.59	Polyketide	pederin	Uncultured bacterium
BGC0001386.1	0.59	Polyketide	JBIR-76, JBIR-77	Streptomyces sp. RI-77
BGC0001625.1	0.59	Polyketide	isofuranonaphthoquinone	Streptomyces sp. CB01883

Similar known gene clusters

No matches found.

Module view

Legend

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 6, location 3801002 - 3877984:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (gly)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 7, location 3801002 - 3844962:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (gly)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_3491

Search NORINE for peptide: strict or relaxed

AMP-binding (491..872): gly

NRPSPredictor2: gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: gly

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGvVWK
Nearest Stachelhaus code:: gly
Stachelhaus code match:: 90% (moderate)

ctg1_3494

CAL_domain (162..486): pk

minowa: NH2

Prediction, score:

NH2: 119.3
Acetyl-CoA: 60.3
fatty_acid: 21.4
shikimic_acid: 0.0
AHBA: 0.0

ctg1_3502

Search NORINE for peptide: strict or relaxed

AMP-binding (38..443): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: ayyaSAHmVK
Nearest Stachelhaus code:: pip
Stachelhaus code match:: 50% (weak)