Select genomic region:
Overview
1.1
1.2
1.3
1.4
1.5
1.6

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP043953.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | NAPAA | 917,621 | 951,619 |
Region 1.2 | redox-cofactor | 1,970,990 | 1,993,180 | lankacidin C | NRP + Polyketide | 13%
Region 1.3 | siderophore | 2,103,171 | 2,121,614 | acinetoferrin | NRP | 30%
Region 1.4 | betalactone | 2,370,059 | 2,399,140 | mycosubtilin | NRP + Polyketide | 20%
Region 1.5 | arylpolyene | 3,074,939 | 3,115,456 | berninamycin A | RiPP | 26%
Region 1.6 | NRPS,hserlactone,arylpolyene | 3,801,003 | 3,877,984 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | NAPAA | 917,621 | 951,619 |
Region 1.2 | redox-cofactor | 1,970,990 | 1,993,180 | lankacidin C | NRP + Polyketide | 13%
Region 1.3 | siderophore | 2,103,171 | 2,121,614 | acinetoferrin | NRP | 30%
Region 1.4 | betalactone | 2,370,059 | 2,399,140 | mycosubtilin | NRP + Polyketide | 20%
Region 1.5 | arylpolyene | 3,074,939 | 3,115,456 | berninamycin A | RiPP | 26%
Region 1.6 | NRPS,hserlactone,arylpolyene | 3,801,003 | 3,877,984 |

No secondary metabolite regions were found in these records:
  NZ_CP043954.1

Compact view
NZ_CP043953.1 - Region 1 - NAPAA
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 917,621 - 951,619 nt. (total: 33,999 nt) Show pHMM detection rules used
NAPAA: (AMP-binding and PP-binding and TIGR02353)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NAPAA | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.22 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001135.1 |  | 0.18 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001641.1 |  | 0.18 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001479.1 |  | 0.18 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001758.1 |  | 0.18 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000375.1 |  | 0.18 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001833.1 |  | 0.18 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001844.1 |  | 0.18 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001128.1 |  | 0.18 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001615.1 |  | 0.18 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.54 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001135.1 |  | 0.50 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001641.1 |  | 0.50 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001479.1 |  | 0.50 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001758.1 |  | 0.50 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000375.1 |  | 0.50 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001833.1 |  | 0.50 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001844.1 |  | 0.50 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001128.1 |  | 0.49 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001615.1 |  | 0.49 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 917620 - 951619:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_833: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (29..418): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DmEHNgTVSK
    Nearest Stachelhaus code:
      dab
    Stachelhaus code match:
      80% (moderate)

NZ_CP043953.1 - Region 2 - redox-cofactor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,970,990 - 1,993,180 nt. (total: 22,191 nt) Show pHMM detection rules used
redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | redox-cofactor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001645.1 |  | 0.22 | RiPP | lagmysin | Streptomyces sp. NRRL S-118
BGC0001176.1 |  | 0.20 | RiPP | streptomonomicin | Streptomonospora alba
BGC0000575.1 |  | 0.20 | RiPP | lariatin | Rhodococcus jostii
BGC0001496.1 |  | 0.20 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0001889.1 |  | 0.20 | RiPP | fusilassin | Thermobifida fusca YX
BGC0001549.1 |  | 0.19 | RiPP | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0001550.1 |  | 0.19 | RiPP | citrulassin D | Streptomyces katrae
BGC0001552.1 |  | 0.19 | RiPP | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001551.1 |  | 0.19 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0001634.1 |  | 0.19 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001645.1 |  | 0.55 | RiPP | lagmysin | Streptomyces sp. NRRL S-118
BGC0001176.1 |  | 0.52 | RiPP | streptomonomicin | Streptomonospora alba
BGC0000575.1 |  | 0.52 | RiPP | lariatin | Rhodococcus jostii
BGC0001496.1 |  | 0.52 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0001889.1 |  | 0.52 | RiPP | fusilassin | Thermobifida fusca YX
BGC0001549.1 |  | 0.52 | RiPP | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0001550.1 |  | 0.51 | RiPP | citrulassin D | Streptomyces katrae
BGC0001552.1 |  | 0.51 | RiPP | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001551.1 |  | 0.51 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0001634.1 |  | 0.51 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP043953.1 - Region 3 - siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,103,171 - 2,121,614 nt. (total: 18,444 nt) Show pHMM detection rules used
siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001478.1 |  | 0.31 | Other | desferrioxamine E | Streptomyces sp. ID38640
BGC0000942.1 |  | 0.28 | Other | petrobactin | Bacillus anthracis str. Ames
BGC0001572.1 |  | 0.27 | Other | desferrioxamine E | Pantoea agglomerans
BGC0000295.1 |  | 0.23 | NRP | acinetoferrin | Acinetobacter haemolyticus
BGC0001499.1 |  | 0.22 | Other | aerobactin | Pantoea ananatis
BGC0000941.1 |  | 0.22 | Other | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001453.1 |  | 0.21 | Other | desferrioxamine | Streptomyces argillaceus
BGC0000940.1 |  | 0.21 | Other | desferrioxamin B, desferrioxamine E | Streptomyces coelicolor A3(2)
BGC0001531.1 |  | 0.21 | Other | bisucaberin B | Tenacibaculum mesophilum
BGC0001870.1 |  | 0.20 | Other | putrebactin, avaroferrin | Xenorhabdus budapestensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001478.1 |  | 0.64 | Other | desferrioxamine E | Streptomyces sp. ID38640
BGC0000942.1 |  | 0.61 | Other | petrobactin | Bacillus anthracis str. Ames
BGC0001572.1 |  | 0.60 | Other | desferrioxamine E | Pantoea agglomerans
BGC0000295.1 |  | 0.57 | NRP | acinetoferrin | Acinetobacter haemolyticus
BGC0001499.1 |  | 0.55 | Other | aerobactin | Pantoea ananatis
BGC0000941.1 |  | 0.54 | Other | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001453.1 |  | 0.54 | Other | desferrioxamine | Streptomyces argillaceus
BGC0000940.1 |  | 0.54 | Other | desferrioxamin B, desferrioxamine E | Streptomyces coelicolor A3(2)
BGC0001531.1 |  | 0.54 | Other | bisucaberin B | Tenacibaculum mesophilum
BGC0001870.1 |  | 0.52 | Other | putrebactin, avaroferrin | Xenorhabdus budapestensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP043953.1 - Region 4 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,370,059 - 2,399,140 nt. (total: 29,082 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000234.1 |  | 0.21 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000258.1 |  | 0.21 | Polyketide | prodigiosin | Serratia sp.
BGC0001897.1 |  | 0.20 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0000259.1 |  | 0.20 | Polyketide | prodigiosin | Serratia marcescens
BGC0000890.1 |  | 0.20 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas phenolica O-BC30
BGC0000891.1 |  | 0.20 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas luteoviolacea 2ta16
BGC0001983.1 |  | 0.17 | Other | triacsins | Kitasatospora aureofaciens
BGC0000373.1 |  | 0.16 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064
BGC0001940.1 |  | 0.16 | Polyketide | pyxidicycline A, pyxidicycline B | Pyxidicoccus fallax
BGC0001730.1 |  | 0.15 | Polyketide | paramagnetoquinone 1, paramagnetoquinone 2 | Actinoallomurus sp.

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000234.1 |  | 0.54 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000258.1 |  | 0.53 | Polyketide | prodigiosin | Serratia sp.
BGC0001897.1 |  | 0.52 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0000259.1 |  | 0.52 | Polyketide | prodigiosin | Serratia marcescens
BGC0000890.1 |  | 0.52 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas phenolica O-BC30
BGC0000891.1 |  | 0.52 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas luteoviolacea 2ta16
BGC0001983.1 |  | 0.48 | Other | triacsins | Kitasatospora aureofaciens
BGC0000373.1 |  | 0.47 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064
BGC0001940.1 |  | 0.46 | Polyketide | pyxidicycline A, pyxidicycline B | Pyxidicoccus fallax
BGC0001730.1 |  | 0.45 | Polyketide | paramagnetoquinone 1, paramagnetoquinone 2 | Actinoallomurus sp.

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP043953.1 - Region 5 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,074,939 - 3,115,456 nt. (total: 40,518 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000779.1 |  | 0.22 | Saccharide | lipopolysaccharide | Aeromonas piscicola
BGC0000780.1 |  | 0.19 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0002008.1 |  | 0.17 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0001343.1 |  | 0.17 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000836.1 |  | 0.17 | Other | APE Ec | Escherichia coli CFT073
BGC0001897.1 |  | 0.17 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001739.1 |  | 0.16 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0001120.1 |  | 0.15 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001917.1 |  | 0.15 | Polyketide | 5-alkyl-1,2,3,4-tetrahydroquinolines, streptoaminals | Streptomyces nigrescens
BGC0001366.1 |  | 0.14 | Polyketide | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000779.1 |  | 0.54 | Saccharide | lipopolysaccharide | Aeromonas piscicola
BGC0000780.1 |  | 0.51 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0002008.1 |  | 0.48 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0001343.1 |  | 0.48 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000836.1 |  | 0.48 | Other | APE Ec | Escherichia coli CFT073
BGC0001897.1 |  | 0.48 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001739.1 |  | 0.47 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0001120.1 |  | 0.45 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001917.1 |  | 0.45 | Polyketide | 5-alkyl-1,2,3,4-tetrahydroquinolines, streptoaminals | Streptomyces nigrescens
BGC0001366.1 |  | 0.44 | Polyketide | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP043953.1 - Region 6 - NRPS,arylpolyene,hserlactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,801,003 - 3,877,984 nt. (total: 76,982 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))
hserlactone: Autoind_synth
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | hserlactone | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0001947.1 |  |  |  | 0.83 | Saccharide | K53 capsular polysaccharide | Acinetobacter baumannii
BGC0001983.1 |  |  |  | 0.63 | Other | triacsins | Kitasatospora aureofaciens
BGC0001343.1 |  |  |  | 0.62 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000343.1 |  |  |  | 0.58 | NRP | enterobactin | Pseudomonas sp. J465
BGC0000220.1 |  |  |  | 0.54 | Polyketide | enterocin | Streptomyces maritimus
BGC0000246.1 |  |  |  | 0.52 | Polyketide | mithramycin | Streptomyces argillaceus
BGC0000274.1 |  |  |  | 0.52 | Polyketide | tetarimycin A, tetarimycin B | uncultured bacterium
BGC0000313.1 |  |  |  | 0.49 | NRP | beauvericin | Beauveria bassiana
BGC0001739.1 |  |  |  | 0.49 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0001897.1 |  |  |  | 0.48 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001947.1 |  | 0.94 | Saccharide | K53 capsular polysaccharide | Acinetobacter baumannii
BGC0001890.1 |  | 0.65 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116
BGC0001615.1 |  | 0.65 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001399.1 |  | 0.64 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001778.1 |  | 0.61 | Other | showdomycin | Streptomyces showdoensis
BGC0000417.1 |  | 0.60 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0000389.1 |  | 0.60 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000255.1 |  | 0.59 | Polyketide | pederin | Uncultured bacterium
BGC0001386.1 |  | 0.59 | Polyketide | JBIR-76, JBIR-77 | Streptomyces sp. RI-77
BGC0001625.1 |  | 0.59 | Polyketide | isofuranonaphthoquinone | Streptomyces sp. CB01883

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 6, location 3801002 - 3877984:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (gly)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 7, location 3801002 - 3844962:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (gly)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_3491: gly
  Search NORINE for peptide: strict or relaxed
  AMP-binding (491..872): gly
  NRPSPredictor2: gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      gly
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQLGvVWK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      90% (moderate)
ctg1_3494: pk
  CAL_domain (162..486): pk
  minowa: NH2
  Prediction, score:
    NH2: 119.3
    Acetyl-CoA: 60.3
    fatty_acid: 21.4
    shikimic_acid: 0.0
    AHBA: 0.0
ctg1_3502: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (38..443): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      ayyaSAHmVK
    Nearest Stachelhaus code:
      pip
    Stachelhaus code match:
      50% (weak)