GCF_000145035.1_ASM14503v1_genomic - 4 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NC_014387.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	NRPS	305,838	363,384
Region 1.2	RRE-containing	1,226,005	1,244,280
Region 1.3	ranthipeptide	2,425,157	2,446,899
Region 1.4	lassopeptide,RRE-containing	2,900,191	2,926,460	capsular polysaccharide	Saccharide	40%

Region	Type	From	To	Most similar known cluster	Similarity
Region 1.1	NRPS	305,838	363,384
Region 1.2	RRE-containing	1,226,005	1,244,280
Region 1.3	ranthipeptide	2,425,157	2,446,899
Region 1.4	lassopeptide,RRE-containing	2,900,191	2,926,460	capsular polysaccharide	Saccharide	40%

No secondary metabolite regions were found in these records:: NC_014388.1; NC_014390.1; NC_014389.1

Compact view

NC_014387.1 - Region 1 - NRPS

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Location: 305,838 - 363,384 nt. (total: 57,547 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001479.1	0.25	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001185.1	0.24	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001833.1	0.23	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0000401.1	0.23	NRP	paenibactin	Paenibacillus elgii B69
BGC0001132.1	0.22	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.1	0.22	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000309.1	0.22	NRP	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0001844.1	0.22	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001131.1	0.22	NRP	ambactin	Xenorhabdus miraniensis
BGC0001767.1	0.21	NRP	salinichelins	Salinispora pacifica CNY331

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001479.1	0.59	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001185.1	0.57	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001833.1	0.56	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0000401.1	0.56	NRP	paenibactin	Paenibacillus elgii B69
BGC0001132.1	0.55	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.1	0.55	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000309.1	0.55	NRP	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0001844.1	0.55	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001131.1	0.55	NRP	ambactin	Xenorhabdus miraniensis
BGC0001767.1	0.54	NRP	salinichelins	Salinispora pacifica CNY331

Similar known gene clusters

No matches found.

Module view

Legend

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 305837 - 363384:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X - X - tyr - D-X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_248

Search NORINE for peptide: strict or relaxed

AMP-binding (58..458): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: gLTvIGgpiK
Nearest Stachelhaus code:: asn
Stachelhaus code match:: 50% (weak)

ctg1_251

Search NORINE for peptide: strict or relaxed

AMP-binding (95..534): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: gFnFiGggaK
Nearest Stachelhaus code:: pip
Stachelhaus code match:: 40% (weak)

ctg1_253

Search NORINE for peptide: strict or relaxed

AMP-binding (442..811): X

NRPSPredictor2: tyr, bht

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAdtMGGvCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 70% (weak)

AMP-binding (1431..1801): X

NRPSPredictor2: val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DgiFmGImFK
Nearest Stachelhaus code:: ile
Stachelhaus code match:: 60% (weak)

AMP-binding (2423..2791): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: tyr

Stachelhaus prediction details:

Stachelhaus sequence:: DSEgTikniK
Nearest Stachelhaus code:: his
Stachelhaus code match:: 50% (weak)

AMP-binding (3409..3782): tyr

NRPSPredictor2: tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: tyr

Stachelhaus prediction details:

Stachelhaus sequence:: DVdHrStVDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 70% (weak)

AMP-binding (4399..4767): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DgdtMGGvCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 60% (weak)

NC_014387.1 - Region 2 - RRE-containing

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Location: 1,226,005 - 1,244,280 nt. (total: 18,276 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000592.1	0.15	RiPP	microviridin B	Microcystis aeruginosa NIES-298
BGC0001407.1	0.15	RiPP	bicereucin	Bacillus cereus SJ1
BGC0000766.1	0.14	Saccharide	exopolysaccharide	Lactobacillus johnsonii
BGC0000623.1	0.13	RiPP	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000703.1	0.13	Saccharide	kanamycin	Streptomyces kanamyceticus
BGC0002009.1	0.13	Polyketide	kanglemycin A, kanglemycin V1, kanglemycin V2	Amycolatopsis vancoresmycina
BGC0000560.1	0.13	RiPP	subtilomycin	Bacillus subtilis
BGC0000543.1	0.13	RiPP	pep5	Staphylococcus epidermidis
BGC0001210.1	0.12	RiPP	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000521.1	0.12	RiPP	lacticin 481	Lactococcus lactis subsp. lactis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000592.1	0.45	RiPP	microviridin B	Microcystis aeruginosa NIES-298
BGC0001407.1	0.45	RiPP	bicereucin	Bacillus cereus SJ1
BGC0000766.1	0.43	Saccharide	exopolysaccharide	Lactobacillus johnsonii
BGC0000623.1	0.42	RiPP	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000703.1	0.41	Saccharide	kanamycin	Streptomyces kanamyceticus
BGC0002009.1	0.41	Polyketide	kanglemycin A, kanglemycin V1, kanglemycin V2	Amycolatopsis vancoresmycina
BGC0000560.1	0.41	RiPP	subtilomycin	Bacillus subtilis
BGC0000543.1	0.41	RiPP	pep5	Staphylococcus epidermidis
BGC0001210.1	0.40	RiPP	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000521.1	0.39	RiPP	lacticin 481	Lactococcus lactis subsp. lactis

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

NC_014387.1 - Region 3 - ranthipeptide

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Location: 2,425,157 - 2,446,899 nt. (total: 21,743 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000599.1	0.13	RiPP	thuricin CD α, thuricin CD β	Bacillus thuringiensis
BGC0002034.1	0.08	Other	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6
BGC0000273.1	0.07	Polyketide, Saccharide	steffimycin D	Streptomyces steffisburgensis
BGC0002026.1	0.06	NRP	thaxteramide A1, thaxteramide A2, thaxteramide B1, thaxteramide B2	Jahnella sp. MSr9139
BGC0001211.1	0.06	NRP	albachelin	Amycolatopsis alba DSM 44262
BGC0000344.1	0.05	NRP	entolysin	Pseudomonas entomophila L48
BGC0000203.1	0.05	Polyketide	BE-7585A	Amycolatopsis orientalis subsp. vinearia
BGC0000413.1	0.03	NRP	pyoverdin	Pseudomonas protegens Pf-5

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000599.1	0.42	RiPP	thuricin CD α, thuricin CD β	Bacillus thuringiensis
BGC0002034.1	0.30	Other	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6
BGC0000273.1	0.27	Polyketide, Saccharide	steffimycin D	Streptomyces steffisburgensis
BGC0002026.1	0.26	NRP	thaxteramide A1, thaxteramide A2, thaxteramide B1, thaxteramide B2	Jahnella sp. MSr9139
BGC0001211.1	0.26	NRP	albachelin	Amycolatopsis alba DSM 44262
BGC0000344.1	0.23	NRP	entolysin	Pseudomonas entomophila L48
BGC0000203.1	0.21	Polyketide	BE-7585A	Amycolatopsis orientalis subsp. vinearia
BGC0000413.1	0.17	NRP	pyoverdin	Pseudomonas protegens Pf-5

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NC_014387.1 - Region 4 - RRE-containing,lassopeptide

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Location: 2,900,191 - 2,926,460 nt. (total: 26,270 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Lasso peptides

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001356.1	0.61	RiPP	paeninodin	Paenibacillus dendritiformis C454
BGC0001634.1	0.61	RiPP	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001645.1	0.54	RiPP	lagmysin	Streptomyces sp. NRRL S-118
BGC0000742.1	0.41	Saccharide	capsular polysaccharide	Streptococcus agalactiae
BGC0000743.1	0.41	Saccharide	capsular polysaccharide	Streptococcus agalactiae
BGC0000578.1	0.40	RiPP	SRO15-2005	Streptomyces filamentosus NRRL 15998
BGC0001894.1	0.39	Saccharide	heteropolysaccharide (HePS)	Lactobacillus plantarum
BGC0000763.1	0.36	Saccharide	stewartan	Pantoea stewartii subsp. stewartii DC283
BGC0000803.1	0.32	Saccharide	GG exopolysaccharide	Lactobacillus rhamnosus GG
BGC0001410.1	0.32	Saccharide	polysaccharide A	Bacteroides fragilis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001356.1	0.64	RiPP	paeninodin	Paenibacillus dendritiformis C454
BGC0001634.1	0.64	RiPP	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001645.1	0.61	RiPP	lagmysin	Streptomyces sp. NRRL S-118
BGC0000742.1	0.53	Saccharide	capsular polysaccharide	Streptococcus agalactiae
BGC0000743.1	0.53	Saccharide	capsular polysaccharide	Streptococcus agalactiae
BGC0000578.1	0.53	RiPP	SRO15-2005	Streptomyces filamentosus NRRL 15998
BGC0001894.1	0.51	Saccharide	heteropolysaccharide (HePS)	Lactobacillus plantarum
BGC0000763.1	0.50	Saccharide	stewartan	Pantoea stewartii subsp. stewartii DC283
BGC0000803.1	0.47	Saccharide	GG exopolysaccharide	Lactobacillus rhamnosus GG
BGC0001410.1	0.47	Saccharide	polysaccharide A	Bacteroides fragilis

Similar known gene clusters

Lasso peptide predictions

Lassopeptides - No core peptides found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Lasso peptides

Core peptide predictions

No core peptides found.