GCF_902374465.1_MGYG-HGUT-01384_genomic - 7 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

c00001_NZ_CABK.. (original name was: NZ_CABKQE010000001.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	arylpolyene,redox-cofactor	1,357,855	1,399,255	APE Vf	Other	10%
Region 1.2	siderophore	1,499,219	1,511,186
Region 1.3	betalactone	1,554,572	1,579,597

c00002_NZ_CABK.. (original name was: NZ_CABKQE010000002.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 2.1	RiPP-like	1,115,172	1,126,041

c00003_NZ_CABK.. (original name was: NZ_CABKQE010000003.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 3.1	terpene	1	16,617
Region 3.2	T1PKS	101,729	149,399	lipopolysaccharide	Saccharide:Lipopolysaccharide	11%
Region 3.3	redox-cofactor	615,549	637,686	lankacidin C	NRP + Polyketide	13%

No secondary metabolite regions were found in these records:: c00004_NZ_CABK.. (original name was: NZ_CABKQE010000004.1); c00005_NZ_CABK.. (original name was: NZ_CABKQE010000005.1); c00006_NZ_CABK.. (original name was: NZ_CABKQE010000006.1); c00007_NZ_CABK.. (original name was: NZ_CABKQE010000007.1); c00008_NZ_CABK.. (original name was: NZ_CABKQE010000008.1); c00009_NZ_CABK.. (original name was: NZ_CABKQE010000009.1); c00010_NZ_CABK.. (original name was: NZ_CABKQE010000010.1); c00011_NZ_CABK.. (original name was: NZ_CABKQE010000011.1); c00012_NZ_CABK.. (original name was: NZ_CABKQE010000012.1); c00013_NZ_CABK.. (original name was: NZ_CABKQE010000013.1); c00014_NZ_CABK.. (original name was: NZ_CABKQE010000014.1); c00015_NZ_CABK.. (original name was: NZ_CABKQE010000015.1); c00016_NZ_CABK.. (original name was: NZ_CABKQE010000016.1); c00017_NZ_CABK.. (original name was: NZ_CABKQE010000017.1)

Compact view

c00001_NZ_CABK.. - Region 1 - arylpolyene,redox-cofactor

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Location: 1,357,855 - 1,399,255 nt. (total: 41,401 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)
redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

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Pfam domains

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002008.1	0.37	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000928.1	0.34	Other	T3 toxin	Cylindrospermopsis raciborskii T3
BGC0000188.1	0.34	Alkaloid	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0001589.1	0.34	Saccharide	exopolysaccharides	Burkholderia cenocepacia J2315
BGC0001588.1	0.33	Saccharide	exopolysaccharides	Burkholderia pseudomallei 1026b
BGC0000883.1	0.32	Other	arginomycin	Streptomyces arginensis
BGC0001120.1	0.32	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0001917.1	0.31	Polyketide	5-alkyl-1,2,3,4-tetrahydroquinolines, streptoaminals	Streptomyces nigrescens
BGC0000255.1	0.29	Polyketide	pederin	Uncultured bacterium
BGC0000700.1	0.29	Saccharide	istamycin	Streptomyces tenjimariensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002008.1	0.62	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000838.1	0.55	Polyketide	flexirubin	Flavobacterium johnsoniae UW101
BGC0000343.1	0.53	NRP	enterobactin	Pseudomonas sp. J465
BGC0001897.1	0.52	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0000255.1	0.52	Polyketide	pederin	Uncultured bacterium
BGC0000260.1	0.50	Polyketide	prodigiosin	Hahella chejuensis KCTC 2396
BGC0001292.1	0.50	Other	A33853	Streptomyces sp. NRRL 12068
BGC0000700.1	0.50	Saccharide	istamycin	Streptomyces tenjimariensis
BGC0002000.1	0.50	Polyketide	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000722.1	0.49	Other (Cyclitol), Polyketide	validamycin A	Streptomyces hygroscopicus subsp. jinggangensis

Similar known gene clusters

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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c00001_NZ_CABK.. - Region 2 - siderophore

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Location: 1,499,219 - 1,511,186 nt. (total: 11,968 nt) Show pHMM detection rules used

siderophore: IucA_IucC

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Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000944.1	0.18	Other (Non-NRP siderophore)	staphyloferrin A	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001408.1	0.15	Other	xanthoferrin	Xanthomonas oryzae pv. oryzae KACC 10331
BGC0001919.1	0.03	NRP, Polyketide	neoantimycin	Streptomyces orinoci

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000944.1	0.50	Other (Non-NRP siderophore)	staphyloferrin A	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001408.1	0.46	Other	xanthoferrin	Xanthomonas oryzae pv. oryzae KACC 10331
BGC0001919.1	0.16	NRP, Polyketide	neoantimycin	Streptomyces orinoci

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

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c00001_NZ_CABK.. - Region 3 - betalactone

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Location: 1,554,572 - 1,579,597 nt. (total: 25,026 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

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transport-related genes

regulatory genes

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001778.1	0.28	Other	showdomycin	Streptomyces showdoensis
BGC0001983.1	0.22	Other	triacsins	Kitasatospora aureofaciens
BGC0000234.1	0.21	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000261.1	0.21	Polyketide	R1128	Streptomyces sp. R1128
BGC0000886.1	0.20	Other	allylmalonyl-CoA	Streptomyces tsukubensis
BGC0001730.1	0.20	Polyketide	paramagnetoquinone 1, paramagnetoquinone 2	Actinoallomurus sp.
BGC0000258.1	0.20	Polyketide	prodigiosin	Serratia sp.
BGC0000891.1	0.19	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas luteoviolacea 2ta16
BGC0000890.1	0.19	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas phenolica O-BC30
BGC0001465.1	0.19	Other	bromopyrroles/bromophenols	Marinomonas mediterranea MMB-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001778.1	0.61	Other	showdomycin	Streptomyces showdoensis
BGC0001983.1	0.55	Other	triacsins	Kitasatospora aureofaciens
BGC0000234.1	0.54	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000261.1	0.54	Polyketide	R1128	Streptomyces sp. R1128
BGC0000886.1	0.53	Other	allylmalonyl-CoA	Streptomyces tsukubensis
BGC0001730.1	0.52	Polyketide	paramagnetoquinone 1, paramagnetoquinone 2	Actinoallomurus sp.
BGC0000258.1	0.52	Polyketide	prodigiosin	Serratia sp.
BGC0000891.1	0.51	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas luteoviolacea 2ta16
BGC0000890.1	0.51	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas phenolica O-BC30
BGC0001465.1	0.51	Other	bromopyrroles/bromophenols	Marinomonas mediterranea MMB-1

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Detailed TIGRFAM domain annotation

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c00002_NZ_CABK.. - Region 1 - RiPP-like

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Location: 1,115,172 - 1,126,041 nt. (total: 10,870 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

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core biosynthetic genes

additional biosynthetic genes

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KnownClusterBlast

Pfam domains

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001120.1	0.18	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0000783.1	0.14	Saccharide	O-antigen	Xanthomonas oryzae pv. oryzae
BGC0000774.1	0.14	Saccharide	lipopolysaccharide	Xanthomonas campestris pv. campestris
BGC0001312.1	0.06	NRP	viscosin	Pseudomonas fluorescens SBW25
BGC0000721.1	0.06	Saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0000133.1	0.04	Polyketide	quartromicin A1	Amycolatopsis orientalis
BGC0000144.1	0.04	Polyketide	salinomycin	Streptomyces albus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001120.1	0.49	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0000783.1	0.44	Saccharide	O-antigen	Xanthomonas oryzae pv. oryzae
BGC0000774.1	0.43	Saccharide	lipopolysaccharide	Xanthomonas campestris pv. campestris
BGC0001312.1	0.27	NRP	viscosin	Pseudomonas fluorescens SBW25
BGC0000721.1	0.26	Saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0000133.1	0.20	Polyketide	quartromicin A1	Amycolatopsis orientalis
BGC0000144.1	0.17	Polyketide	salinomycin	Streptomyces albus

Similar known gene clusters

No matches found.

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Detailed TIGRFAM domain annotation

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c00003_NZ_CABK.. - Region 1 - terpene

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Location: 1 - 16,617 nt. (total: 16,617 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

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core biosynthetic genes

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KnownClusterBlast

Pfam domains

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001120.1	0.18	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0000643.1	0.18	Terpene	carotenoid	Brevundimonas vesicularis
BGC0000634.1	0.18	Terpene	carotenoid	Brevundimonas sp. SD212
BGC0000630.1	0.15	Terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000527.1	0.15	RiPP	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000515.1	0.14	RiPP	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0001727.1	0.13	RiPP	paenilan	Paenibacillus polymyxa E681
BGC0000928.1	0.13	Other	T3 toxin	Cylindrospermopsis raciborskii T3
BGC0000188.1	0.13	Alkaloid	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000642.1	0.12	Terpene	carotenoid	Enterobacteriaceae bacterium DC413

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001120.1	0.50	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0000643.1	0.50	Terpene	carotenoid	Brevundimonas vesicularis
BGC0000634.1	0.49	Terpene	carotenoid	Brevundimonas sp. SD212
BGC0000630.1	0.46	Terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000527.1	0.45	RiPP	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000515.1	0.43	RiPP	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0001727.1	0.41	RiPP	paenilan	Paenibacillus polymyxa E681
BGC0000928.1	0.41	Other	T3 toxin	Cylindrospermopsis raciborskii T3
BGC0000188.1	0.41	Alkaloid	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000642.1	0.39	Terpene	carotenoid	Enterobacteriaceae bacterium DC413

Similar known gene clusters

No matches found.

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Detailed TIGRFAM domain annotation

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c00003_NZ_CABK.. - Region 2 - T1PKS

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Location: 101,729 - 149,399 nt. (total: 47,671 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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NRPS/PKS domains

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NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

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Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.31	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001697.1	0.31	Polyketide	neurosporin A	Neurospora crassa OR74A
BGC0001067.1	0.31	Polyketide, Terpene	fumagillin, β-trans-bergamotene, fumagillol	Aspergillus fumigatus Af293
BGC0001913.1	0.29	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0001124.1	0.28	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0001749.1	0.28	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0001340.1	0.28	Polyketide	byssochlamic acid	Byssochlamys fulva
BGC0000046.1	0.27	Polyketide	depudecin	Alternaria brassicicola
BGC0000800.1	0.25	Saccharide	xanthan	Xanthomonas campestris
BGC0001504.1	0.25	Polyketide	amycomicin	Amycolatopsis sp. AA4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.65	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001697.1	0.65	Polyketide	neurosporin A	Neurospora crassa OR74A
BGC0001067.1	0.64	Polyketide, Terpene	fumagillin, β-trans-bergamotene, fumagillol	Aspergillus fumigatus Af293
BGC0001913.1	0.62	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0001124.1	0.62	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0001749.1	0.62	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0001340.1	0.62	Polyketide	byssochlamic acid	Byssochlamys fulva
BGC0000046.1	0.61	Polyketide	depudecin	Alternaria brassicicola
BGC0000800.1	0.59	Saccharide	xanthan	Xanthomonas campestris
BGC0001504.1	0.59	Polyketide	amycomicin	Amycolatopsis sp. AA4

Similar known gene clusters

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 2, location 101728 - 149399:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg3_104

PKS_AT (541..840): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 66.7%; Methoxymalonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 105.0
Methoxymalonyl-CoA: 93.8
Malonyl-CoA: 81.4
Ethylmalonyl-CoA: 59.0
Isobutyryl-CoA: 53.8
2-Methylbutyryl-CoA: 49.4
trans-1,2-CPDA: 48.0
Propionyl-CoA: 43.3
inactive: 31.2
fatty_acid: 30.5
Benzoyl-CoA: 26.3
CHC-CoA: 25.6
3-Methylbutyryl-CoA: 17.3
Acetyl-CoA: 6.5

c00003_NZ_CABK.. - Region 3 - redox-cofactor

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Location: 615,549 - 637,686 nt. (total: 22,138 nt) Show pHMM detection rules used

redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001588.1	0.16	Saccharide	exopolysaccharides	Burkholderia pseudomallei 1026b
BGC0001589.1	0.16	Saccharide	exopolysaccharides	Burkholderia cenocepacia J2315
BGC0001925.1	0.14	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0001057.1	0.12	NRP, Polyketide	zearalenone	Fusarium graminearum
BGC0001838.1	0.11	NRP	WLIP	Pseudomonas putida
BGC0001865.1	0.10	Polyketide	elsinochrome C	Parastagonospora nodorum SN15
BGC0001739.1	0.10	Other	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0001100.1	0.09	NRP, Polyketide	lankacidin C	Streptomyces rochei
BGC0001120.1	0.09	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0001338.1	0.09	Polyketide	citrinin	Monascus ruber

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001588.1	0.47	Saccharide	exopolysaccharides	Burkholderia pseudomallei 1026b
BGC0001589.1	0.47	Saccharide	exopolysaccharides	Burkholderia cenocepacia J2315
BGC0001925.1	0.43	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0001057.1	0.39	NRP, Polyketide	zearalenone	Fusarium graminearum
BGC0001838.1	0.38	NRP	WLIP	Pseudomonas putida
BGC0001865.1	0.35	Polyketide	elsinochrome C	Parastagonospora nodorum SN15
BGC0001739.1	0.35	Other	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0001100.1	0.34	NRP, Polyketide	lankacidin C	Streptomyces rochei
BGC0001120.1	0.33	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0001338.1	0.33	Polyketide	citrinin	Monascus ruber

Similar known gene clusters

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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