GCF_900445995.1_48290_B02_genomic - 4 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_UIGE01000001 (original name was: NZ_UIGE01000001.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 2.1	resorcinol	321,430	362,566
Region 2.2	RRE-containing	1,299,521	1,319,227
Region 2.3	lassopeptide	1,560,725	1,583,135
Region 2.4	NRPS	2,472,885	2,516,760	fuscachelin A / fuscachelin B / fuscachelin C	NRP	44%

Region	Type	From	To	Most similar known cluster	Similarity
Region 2.1	resorcinol	321,430	362,566
Region 2.2	RRE-containing	1,299,521	1,319,227
Region 2.3	lassopeptide	1,560,725	1,583,135
Region 2.4	NRPS	2,472,885	2,516,760	fuscachelin A / fuscachelin B / fuscachelin C	NRP	44%

No secondary metabolite regions were found in these records:: NZ_UIGE01000002 (original name was: NZ_UIGE01000002.1)

Compact view

c00002_NZ_UIGE.. - Region 1 - resorcinol

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Location: 321,430 - 362,566 nt. (total: 41,137 nt) Show pHMM detection rules used

resorcinol: DarB

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001526.1	0.21	Other	bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K	Synechocystis salina LEGE 06099
BGC0001525.1	0.20	Other	bartoloside 2, bartoloside 3, bartoloside 4	Synechocystis salina LEGE 06155
BGC0000249.1	0.17	Polyketide	nogalamycin	Streptomyces nogalater
BGC0000922.1	0.16	Other	pseudomonas quinolone signal (PQS)	Pseudomonas aeruginosa PAO1
BGC0001736.1	0.14	NRP	pepteridine A, pepteridine B	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000894.1	0.14	Other	citrinin	Monascus aurantiacus
BGC0000010.1	0.13	Polyketide	aflatoxin	Aspergillus flavus
BGC0001615.1	0.11	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0000838.1	0.09	Polyketide	flexirubin	Flavobacterium johnsoniae UW101
BGC0000321.1	0.09	NRP	chaetocin	Collariella virescens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001526.1	0.54	Other	bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K	Synechocystis salina LEGE 06099
BGC0001525.1	0.52	Other	bartoloside 2, bartoloside 3, bartoloside 4	Synechocystis salina LEGE 06155
BGC0000249.1	0.49	Polyketide	nogalamycin	Streptomyces nogalater
BGC0000922.1	0.47	Other	pseudomonas quinolone signal (PQS)	Pseudomonas aeruginosa PAO1
BGC0001736.1	0.44	NRP	pepteridine A, pepteridine B	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000894.1	0.43	Other	citrinin	Monascus aurantiacus
BGC0000010.1	0.42	Polyketide	aflatoxin	Aspergillus flavus
BGC0001615.1	0.37	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0000838.1	0.33	Polyketide	flexirubin	Flavobacterium johnsoniae UW101
BGC0000321.1	0.32	NRP	chaetocin	Collariella virescens

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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c00002_NZ_UIGE.. - Region 2 - RRE-containing

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Location: 1,299,521 - 1,319,227 nt. (total: 19,707 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001779.1	0.23	RiPP	siamycin	Streptomyces nodosus
BGC0000554.1	0.21	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000516.1	0.21	RiPP	geobacillin II	Geobacillus thermodenitrificans
BGC0000571.1	0.21	RiPP	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000576.1	0.20	RiPP	rubrivinodin	Rubrivivax gelatinosus IL144
BGC0000572.1	0.20	RiPP	capistruin	Burkholderia thailandensis E444
BGC0000502.1	0.20	RiPP	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0001210.1	0.20	RiPP	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000580.1	0.19	RiPP	xanthomonin I, xanthomonin II	Xanthomonas gardneri ATCC 19865
BGC0000504.1	0.19	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001779.1	0.57	RiPP	siamycin	Streptomyces nodosus
BGC0000554.1	0.54	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000516.1	0.54	RiPP	geobacillin II	Geobacillus thermodenitrificans
BGC0000571.1	0.53	RiPP	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000576.1	0.53	RiPP	rubrivinodin	Rubrivivax gelatinosus IL144
BGC0000572.1	0.53	RiPP	capistruin	Burkholderia thailandensis E444
BGC0000502.1	0.52	RiPP	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0001210.1	0.52	RiPP	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000580.1	0.52	RiPP	xanthomonin I, xanthomonin II	Xanthomonas gardneri ATCC 19865
BGC0000504.1	0.52	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

c00002_NZ_UIGE.. - Region 3 - lassopeptide

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Location: 1,560,725 - 1,583,135 nt. (total: 22,411 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG comparison

KnownClusterBlast

Lasso peptides

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000576.1	0.32	RiPP	rubrivinodin	Rubrivivax gelatinosus IL144
BGC0000570.1	0.31	RiPP	astexin-1	Asticcacaulis excentricus CB 48
BGC0000580.1	0.29	RiPP	xanthomonin I, xanthomonin II	Xanthomonas gardneri ATCC 19865
BGC0000574.1	0.28	RiPP	caulosegnin I, caulosegnin II, caulosegnin III	Caulobacter segnis ATCC 21756
BGC0000577.1	0.22	RiPP	sphingonodin II	Sphingobium japonicum UT26S
BGC0000573.1	0.22	RiPP	caulonodin I, caulonodin II	Caulobacter sp. K31
BGC0001786.1	0.20	RiPP	subterisin	Novosphingobium subterraneum
BGC0001189.1	0.05	NRP	taiwachelin	Cupriavidus taiwanensis LMG 19424

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000576.1	0.65	RiPP	rubrivinodin	Rubrivivax gelatinosus IL144
BGC0000570.1	0.65	RiPP	astexin-1	Asticcacaulis excentricus CB 48
BGC0000580.1	0.63	RiPP	xanthomonin I, xanthomonin II	Xanthomonas gardneri ATCC 19865
BGC0000574.1	0.62	RiPP	caulosegnin I, caulosegnin II, caulosegnin III	Caulobacter segnis ATCC 21756
BGC0000577.1	0.55	RiPP	sphingonodin II	Sphingobium japonicum UT26S
BGC0000573.1	0.55	RiPP	caulonodin I, caulonodin II	Caulobacter sp. K31
BGC0001786.1	0.53	RiPP	subterisin	Novosphingobium subterraneum
BGC0001189.1	0.23	NRP	taiwachelin	Cupriavidus taiwanensis LMG 19424

Similar known gene clusters

No matches found.

Lasso peptide predictions

Lassopeptides - No core peptides found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Lasso peptides

Core peptide predictions

No core peptides found.

c00002_NZ_UIGE.. - Region 4 - NRPS

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Location: 2,472,885 - 2,516,760 nt. (total: 43,876 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.1	0.27	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001302.1	0.26	Other	lomofungin	Streptomyces lomondensis
BGC0001833.1	0.25	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0000401.1	0.25	NRP	paenibactin	Paenibacillus elgii B69
BGC0001758.1	0.24	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001132.1	0.24	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.1	0.23	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.1	0.23	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001149.1	0.23	NRP, Saccharide	brabantamide A	Pseudomonas sp. SHC52
BGC0001131.1	0.23	NRP	ambactin	Xenorhabdus miraniensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.1	0.61	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001302.1	0.59	Other	lomofungin	Streptomyces lomondensis
BGC0001833.1	0.59	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0000401.1	0.58	NRP	paenibactin	Paenibacillus elgii B69
BGC0001758.1	0.57	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001132.1	0.57	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.1	0.57	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.1	0.57	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001149.1	0.57	NRP, Saccharide	brabantamide A	Pseudomonas sp. SHC52
BGC0001131.1	0.56	NRP	ambactin	Xenorhabdus miraniensis

Similar known gene clusters

Module view

Legend

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 4, location 2472884 - 2516760:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg2_2414

Search NORINE for peptide: strict or relaxed

AMP-binding (458..846): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLVDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

ctg2_2417

Search NORINE for peptide: strict or relaxed

AMP-binding (31..437): dhb

NRPSPredictor2: dhb

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: PMPglGVVNK
Nearest Stachelhaus code:: dhb
Stachelhaus code match:: 80% (moderate)