Select genomic region:
Overview
2.1
2.2
2.3
2.4

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_UIGE01000001 (original name was: NZ_UIGE01000001.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | resorcinol | 321,430 | 362,566 |
Region 2.2 | RRE-containing | 1,299,521 | 1,319,227 |
Region 2.3 | lassopeptide | 1,560,725 | 1,583,135 |
Region 2.4 | NRPS | 2,472,885 | 2,516,760 | fuscachelin A / fuscachelin B / fuscachelin C | NRP | 44%

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | resorcinol | 321,430 | 362,566 |
Region 2.2 | RRE-containing | 1,299,521 | 1,319,227 |
Region 2.3 | lassopeptide | 1,560,725 | 1,583,135 |
Region 2.4 | NRPS | 2,472,885 | 2,516,760 | fuscachelin A / fuscachelin B / fuscachelin C | NRP | 44%

No secondary metabolite regions were found in these records:
  NZ_UIGE01000002 (original name was: NZ_UIGE01000002.1)

Compact view
c00002_NZ_UIGE.. - Region 1 - resorcinol
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 321,430 - 362,566 nt. (total: 41,137 nt) Show pHMM detection rules used
resorcinol: DarB

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | resorcinol | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001526.1 |  | 0.21 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0001525.1 |  | 0.20 | Other | bartoloside 2, bartoloside 3, bartoloside 4 | Synechocystis salina LEGE 06155
BGC0000249.1 |  | 0.17 | Polyketide | nogalamycin | Streptomyces nogalater
BGC0000922.1 |  | 0.16 | Other | pseudomonas quinolone signal (PQS) | Pseudomonas aeruginosa PAO1
BGC0001736.1 |  | 0.14 | NRP | pepteridine A, pepteridine B | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000894.1 |  | 0.14 | Other | citrinin | Monascus aurantiacus
BGC0000010.1 |  | 0.13 | Polyketide | aflatoxin | Aspergillus flavus
BGC0001615.1 |  | 0.11 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000838.1 |  | 0.09 | Polyketide | flexirubin | Flavobacterium johnsoniae UW101
BGC0000321.1 |  | 0.09 | NRP | chaetocin | Collariella virescens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001526.1 |  | 0.54 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0001525.1 |  | 0.52 | Other | bartoloside 2, bartoloside 3, bartoloside 4 | Synechocystis salina LEGE 06155
BGC0000249.1 |  | 0.49 | Polyketide | nogalamycin | Streptomyces nogalater
BGC0000922.1 |  | 0.47 | Other | pseudomonas quinolone signal (PQS) | Pseudomonas aeruginosa PAO1
BGC0001736.1 |  | 0.44 | NRP | pepteridine A, pepteridine B | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000894.1 |  | 0.43 | Other | citrinin | Monascus aurantiacus
BGC0000010.1 |  | 0.42 | Polyketide | aflatoxin | Aspergillus flavus
BGC0001615.1 |  | 0.37 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000838.1 |  | 0.33 | Polyketide | flexirubin | Flavobacterium johnsoniae UW101
BGC0000321.1 |  | 0.32 | NRP | chaetocin | Collariella virescens

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00002_NZ_UIGE.. - Region 2 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,299,521 - 1,319,227 nt. (total: 19,707 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001779.1 |  | 0.23 | RiPP | siamycin | Streptomyces nodosus
BGC0000554.1 |  | 0.21 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000516.1 |  | 0.21 | RiPP | geobacillin II | Geobacillus thermodenitrificans
BGC0000571.1 |  | 0.21 | RiPP | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000576.1 |  | 0.20 | RiPP | rubrivinodin | Rubrivivax gelatinosus IL144
BGC0000572.1 |  | 0.20 | RiPP | capistruin | Burkholderia thailandensis E444
BGC0000502.1 |  | 0.20 | RiPP | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0001210.1 |  | 0.20 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000580.1 |  | 0.19 | RiPP | xanthomonin I, xanthomonin II | Xanthomonas gardneri ATCC 19865
BGC0000504.1 |  | 0.19 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001779.1 |  | 0.57 | RiPP | siamycin | Streptomyces nodosus
BGC0000554.1 |  | 0.54 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000516.1 |  | 0.54 | RiPP | geobacillin II | Geobacillus thermodenitrificans
BGC0000571.1 |  | 0.53 | RiPP | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000576.1 |  | 0.53 | RiPP | rubrivinodin | Rubrivivax gelatinosus IL144
BGC0000572.1 |  | 0.53 | RiPP | capistruin | Burkholderia thailandensis E444
BGC0000502.1 |  | 0.52 | RiPP | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0001210.1 |  | 0.52 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000580.1 |  | 0.52 | RiPP | xanthomonin I, xanthomonin II | Xanthomonas gardneri ATCC 19865
BGC0000504.1 |  | 0.52 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00002_NZ_UIGE.. - Region 3 - lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,560,725 - 1,583,135 nt. (total: 22,411 nt) Show pHMM detection rules used
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lasso peptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lassopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000576.1 |  | 0.32 | RiPP | rubrivinodin | Rubrivivax gelatinosus IL144
BGC0000570.1 |  | 0.31 | RiPP | astexin-1 | Asticcacaulis excentricus CB 48
BGC0000580.1 |  | 0.29 | RiPP | xanthomonin I, xanthomonin II | Xanthomonas gardneri ATCC 19865
BGC0000574.1 |  | 0.28 | RiPP | caulosegnin I, caulosegnin II, caulosegnin III | Caulobacter segnis ATCC 21756
BGC0000577.1 |  | 0.22 | RiPP | sphingonodin II | Sphingobium japonicum UT26S
BGC0000573.1 |  | 0.22 | RiPP | caulonodin I, caulonodin II | Caulobacter sp. K31
BGC0001786.1 |  | 0.20 | RiPP | subterisin | Novosphingobium subterraneum
BGC0001189.1 |  | 0.05 | NRP | taiwachelin | Cupriavidus taiwanensis LMG 19424

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000576.1 |  | 0.65 | RiPP | rubrivinodin | Rubrivivax gelatinosus IL144
BGC0000570.1 |  | 0.65 | RiPP | astexin-1 | Asticcacaulis excentricus CB 48
BGC0000580.1 |  | 0.63 | RiPP | xanthomonin I, xanthomonin II | Xanthomonas gardneri ATCC 19865
BGC0000574.1 |  | 0.62 | RiPP | caulosegnin I, caulosegnin II, caulosegnin III | Caulobacter segnis ATCC 21756
BGC0000577.1 |  | 0.55 | RiPP | sphingonodin II | Sphingobium japonicum UT26S
BGC0000573.1 |  | 0.55 | RiPP | caulonodin I, caulonodin II | Caulobacter sp. K31
BGC0001786.1 |  | 0.53 | RiPP | subterisin | Novosphingobium subterraneum
BGC0001189.1 |  | 0.23 | NRP | taiwachelin | Cupriavidus taiwanensis LMG 19424

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.
Lassopeptides - No core peptides found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lasso peptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.
c00002_NZ_UIGE.. - Region 4 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,472,885 - 2,516,760 nt. (total: 43,876 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001185.1 |  | 0.27 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0001302.1 |  | 0.26 | Other | lomofungin | Streptomyces lomondensis
BGC0001833.1 |  | 0.25 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000401.1 |  | 0.25 | NRP | paenibactin | Paenibacillus elgii B69
BGC0001758.1 |  | 0.24 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001132.1 |  | 0.24 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.1 |  | 0.23 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.1 |  | 0.23 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001149.1 |  | 0.23 | NRP, Saccharide | brabantamide A | Pseudomonas sp. SHC52
BGC0001131.1 |  | 0.23 | NRP | ambactin | Xenorhabdus miraniensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001185.1 |  | 0.61 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0001302.1 |  | 0.59 | Other | lomofungin | Streptomyces lomondensis
BGC0001833.1 |  | 0.59 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000401.1 |  | 0.58 | NRP | paenibactin | Paenibacillus elgii B69
BGC0001758.1 |  | 0.57 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001132.1 |  | 0.57 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.1 |  | 0.57 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.1 |  | 0.57 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001149.1 |  | 0.57 | NRP, Saccharide | brabantamide A | Pseudomonas sp. SHC52
BGC0001131.1 |  | 0.56 | NRP | ambactin | Xenorhabdus miraniensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 4, location 2472884 - 2516760:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ser)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg2_2414: ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (458..846): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
ctg2_2417: dhb
  Search NORINE for peptide: strict or relaxed
  AMP-binding (31..437): dhb
  NRPSPredictor2: dhb
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      dhb, sal
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      PMPglGVVNK
    Nearest Stachelhaus code:
      dhb
    Stachelhaus code match:
      80% (moderate)