GCF_900142955.1_IMG-taxon_2588253509_annotated_assembly_genomic - 10 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_FRCP01000014 (original name was: NZ_FRCP01000014.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 16.1	ranthipeptide	143,252	164,948	locillomycin	NRP + Polyketide	14%

NZ_FRCP01000018 (original name was: NZ_FRCP01000018.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 17.1	ranthipeptide	25,206	46,615

NZ_FRCP01000005 (original name was: NZ_FRCP01000005.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 20.1	NRPS	1	44,170

NZ_FRCP01000009 (original name was: NZ_FRCP01000009.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 27.1	NRPS-like	49,336	92,644
Region 27.2	RRE-containing	191,476	211,766

NZ_FRCP01000012 (original name was: NZ_FRCP01000012.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 29.1	cyclic-lactone-autoinducer	66,328	86,924

NZ_FRCP01000015 (original name was: NZ_FRCP01000015.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 33.1	cyclic-lactone-autoinducer	65,060	85,771

NZ_FRCP01000017 (original name was: NZ_FRCP01000017.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 39.1	betalactone	72,210	97,062	pseudaminic acid	Other	33%

NZ_FRCP01000011 (original name was: NZ_FRCP01000011.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 40.1	transAT-PKS,NRPS	37,829	129,054
Region 40.2	NRPS-like	152,138	193,979

No secondary metabolite regions were found in these records:: NZ_FRCP01000042 (original name was: NZ_FRCP01000042.1); NZ_FRCP01000040 (original name was: NZ_FRCP01000040.1); NZ_FRCP01000038 (original name was: NZ_FRCP01000038.1); NZ_FRCP01000037 (original name was: NZ_FRCP01000037.1); NZ_FRCP01000034 (original name was: NZ_FRCP01000034.1); NZ_FRCP01000033 (original name was: NZ_FRCP01000033.1); NZ_FRCP01000032 (original name was: NZ_FRCP01000032.1); NZ_FRCP01000041 (original name was: NZ_FRCP01000041.1); NZ_FRCP01000030 (original name was: NZ_FRCP01000030.1); NZ_FRCP01000036 (original name was: NZ_FRCP01000036.1); NZ_FRCP01000029 (original name was: NZ_FRCP01000029.1); NZ_FRCP01000026 (original name was: NZ_FRCP01000026.1); NZ_FRCP01000025 (original name was: NZ_FRCP01000025.1); NZ_FRCP01000024 (original name was: NZ_FRCP01000024.1); NZ_FRCP01000023 (original name was: NZ_FRCP01000023.1); NZ_FRCP01000008 (original name was: NZ_FRCP01000008.1); NZ_FRCP01000027 (original name was: NZ_FRCP01000027.1); NZ_FRCP01000043 (original name was: NZ_FRCP01000043.1); NZ_FRCP01000007 (original name was: NZ_FRCP01000007.1); NZ_FRCP01000004 (original name was: NZ_FRCP01000004.1); NZ_FRCP01000006 (original name was: NZ_FRCP01000006.1); NZ_FRCP01000031 (original name was: NZ_FRCP01000031.1); NZ_FRCP01000028 (original name was: NZ_FRCP01000028.1); NZ_FRCP01000010 (original name was: NZ_FRCP01000010.1); NZ_FRCP01000045 (original name was: NZ_FRCP01000045.1); NZ_FRCP01000013 (original name was: NZ_FRCP01000013.1); NZ_FRCP01000016 (original name was: NZ_FRCP01000016.1); NZ_FRCP01000019 (original name was: NZ_FRCP01000019.1); NZ_FRCP01000020 (original name was: NZ_FRCP01000020.1); NZ_FRCP01000044 (original name was: NZ_FRCP01000044.1); NZ_FRCP01000039 (original name was: NZ_FRCP01000039.1); NZ_FRCP01000035 (original name was: NZ_FRCP01000035.1); NZ_FRCP01000021 (original name was: NZ_FRCP01000021.1); NZ_FRCP01000022 (original name was: NZ_FRCP01000022.1)

Compact view

c00016_NZ_FRCP.. - Region 1 - ranthipeptide

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Location: 143,252 - 164,948 nt. (total: 21,697 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

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core biosynthetic genes

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000600.1	0.19	RiPP	thurincin H	Bacillus thuringiensis
BGC0000548.1	0.16	RiPP	salivaricin A	Streptococcus salivarius
BGC0000554.1	0.16	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000556.1	0.16	RiPP	streptin	Streptococcus pyogenes
BGC0000547.1	0.16	RiPP	salivaricin 9	Streptococcus salivarius
BGC0001289.1	0.16	RiPP	penisin	Paenibacillus ehimensis
BGC0000506.1	0.16	RiPP	entianin	Bacillus subtilis subsp. spizizenii
BGC0000502.1	0.16	RiPP	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0000517.1	0.16	RiPP	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001391.1	0.16	RiPP	thusin	Bacillus thuringiensis serovar rongseni

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000600.1	0.51	RiPP	thurincin H	Bacillus thuringiensis
BGC0000548.1	0.47	RiPP	salivaricin A	Streptococcus salivarius
BGC0000554.1	0.47	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000556.1	0.47	RiPP	streptin	Streptococcus pyogenes
BGC0000547.1	0.47	RiPP	salivaricin 9	Streptococcus salivarius
BGC0001289.1	0.47	RiPP	penisin	Paenibacillus ehimensis
BGC0000506.1	0.47	RiPP	entianin	Bacillus subtilis subsp. spizizenii
BGC0000502.1	0.47	RiPP	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0000517.1	0.47	RiPP	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001391.1	0.46	RiPP	thusin	Bacillus thuringiensis serovar rongseni

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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c00017_NZ_FRCP.. - Region 1 - ranthipeptide

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Location: 25,206 - 46,615 nt. (total: 21,410 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000600.1	0.20	RiPP	thurincin H	Bacillus thuringiensis
BGC0000521.1	0.17	RiPP	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000539.1	0.17	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0000626.1	0.17	RiPP	thuricin	Bacillus thuringiensis
BGC0000498.1	0.17	RiPP	bovicin HJ50	Streptococcus equinus
BGC0000561.1	0.17	RiPP	thermophilin 1277	Streptococcus thermophilus
BGC0000616.1	0.16	RiPP	amylocyclicin	Bacillus velezensis FZB42
BGC0000486.1	0.16	RiPP	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0001222.1	0.16	RiPP	acidocin B	Lactobacillus acidophilus
BGC0000491.1	0.16	RiPP	gassericin A	Lactobacillus gasseri

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000600.1	0.52	RiPP	thurincin H	Bacillus thuringiensis
BGC0000521.1	0.49	RiPP	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000539.1	0.48	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0000626.1	0.48	RiPP	thuricin	Bacillus thuringiensis
BGC0000498.1	0.48	RiPP	bovicin HJ50	Streptococcus equinus
BGC0000561.1	0.48	RiPP	thermophilin 1277	Streptococcus thermophilus
BGC0000616.1	0.47	RiPP	amylocyclicin	Bacillus velezensis FZB42
BGC0000486.1	0.47	RiPP	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0001222.1	0.47	RiPP	acidocin B	Lactobacillus acidophilus
BGC0000491.1	0.47	RiPP	gassericin A	Lactobacillus gasseri

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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c00020_NZ_FRCP.. - Region 1 - NRPS

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Location: 1 - 44,170 nt. (total: 44,170 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000426.1	0.39	NRP	sevadicin	Paenibacillus larvae
BGC0000389.1	0.32	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000457.1	0.31	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001671.1	0.29	NRP	monobactam	Agrobacterium tumefaciens
BGC0000349.1	0.29	NRP	erythrochelin	Saccharopolyspora erythraea NRRL 2338
BGC0001479.1	0.28	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001502.1	0.28	NRP	amonabactin P 750	Aeromonas hydrophila subsp. hydrophila ATCC 7966
BGC0000351.1	0.27	NRP	exochelin	Mycolicibacterium smegmatis
BGC0000430.1	0.26	NRP, Polyketide	spumigin E	Nodularia spumigena CCY9414
BGC0000417.1	0.26	NRP	rhodochelin	Rhodococcus jostii RHA1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000426.1	0.71	NRP	sevadicin	Paenibacillus larvae
BGC0000389.1	0.66	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000457.1	0.64	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001671.1	0.63	NRP	monobactam	Agrobacterium tumefaciens
BGC0000349.1	0.62	NRP	erythrochelin	Saccharopolyspora erythraea NRRL 2338
BGC0001479.1	0.61	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001502.1	0.61	NRP	amonabactin P 750	Aeromonas hydrophila subsp. hydrophila ATCC 7966
BGC0000351.1	0.61	NRP	exochelin	Mycolicibacterium smegmatis
BGC0000430.1	0.59	NRP, Polyketide	spumigin E	Nodularia spumigena CCY9414
BGC0000417.1	0.59	NRP	rhodochelin	Rhodococcus jostii RHA1

Similar known gene clusters

No matches found.

Module view

Legend

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 44170:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (asp - D-glu) + (D-X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg20_10

Search NORINE for peptide: strict or relaxed

AMP-binding (524..926): X

NRPSPredictor2: asp, asn, glu, gln, aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAKDvGVdvK
Nearest Stachelhaus code:: glu
Stachelhaus code match:: 70% (weak)

ctg20_11

Search NORINE for peptide: strict or relaxed

CAL_domain (179..493): pk

minowa: fatty_acid

Prediction, score:

fatty_acid: 88.2
shikimic_acid: 0.0
NH2: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

AMP-binding (1142..1546): asp

NRPSPredictor2: asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: asp

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKVGHIGK
Nearest Stachelhaus code:: asp
Stachelhaus code match:: 100% (strong)

AMP-binding (2187..2597): glu

NRPSPredictor2: glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: glu, gln
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAKDLGVVDK
Nearest Stachelhaus code:: glu
Stachelhaus code match:: 100% (strong)

c00027_NZ_FRCP.. - Region 1 - NRPS-like

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Location: 49,336 - 92,644 nt. (total: 43,309 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000427.1	0.65	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000375.1	0.65	NRP	indigoidine	Streptomyces chromofuscus
BGC0002002.1	0.59	NRP	1,6-phenazinedimethanol, fontizine A	Serratia fonticola
BGC0000426.1	0.58	NRP	sevadicin	Paenibacillus larvae
BGC0000465.1	0.57	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0000389.1	0.56	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001527.1	0.55	Other	basidioferrin	Gelatoporia subvermispora
BGC0000921.1	0.55	Other (Shikimate-derived), Polyketide, NRP	promysalin	Pseudomonas putida
BGC0000348.1	0.54	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001050.1	0.54	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000427.1	0.66	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000375.1	0.66	NRP	indigoidine	Streptomyces chromofuscus
BGC0002002.1	0.63	NRP	1,6-phenazinedimethanol, fontizine A	Serratia fonticola
BGC0000426.1	0.62	NRP	sevadicin	Paenibacillus larvae
BGC0000465.1	0.62	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0000389.1	0.61	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001527.1	0.61	Other	basidioferrin	Gelatoporia subvermispora
BGC0000921.1	0.61	Other (Shikimate-derived), Polyketide, NRP	promysalin	Pseudomonas putida
BGC0000348.1	0.61	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001050.1	0.61	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis

Similar known gene clusters

No matches found.

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 49335 - 92644:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 49335 - 90648:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 50829 - 92644:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg27_72

Search NORINE for peptide: strict or relaxed

AMP-binding (15..403): X

NRPSPredictor2: hydrophobic-aromatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DiWeLtadDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 50% (weak)

ctg27_73

Search NORINE for peptide: strict or relaxed

AMP-binding (18..422): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DYWSVGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

c00027_NZ_FRCP.. - Region 2 - RRE-containing

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Location: 191,476 - 211,766 nt. (total: 20,291 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001859.1	0.24	Other (Phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000904.1	0.21	Other	FR-900098	Streptomyces rubellomurinus
BGC0001496.1	0.17	RiPP	actinokineosin	Actinokineospora spheciospongiae
BGC0000504.1	0.16	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001576.1	0.16	RiPP	divamide A	Prochloron didemni
BGC0000500.1	0.16	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000554.1	0.16	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000558.1	0.16	RiPP	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001526.1	0.16	Other	bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K	Synechocystis salina LEGE 06099
BGC0001120.1	0.16	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001859.1	0.57	Other (Phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000904.1	0.54	Other	FR-900098	Streptomyces rubellomurinus
BGC0001496.1	0.49	RiPP	actinokineosin	Actinokineospora spheciospongiae
BGC0000504.1	0.47	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001576.1	0.46	RiPP	divamide A	Prochloron didemni
BGC0000500.1	0.46	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000554.1	0.46	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000558.1	0.46	RiPP	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001526.1	0.46	Other	bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K	Synechocystis salina LEGE 06099
BGC0001120.1	0.46	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

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c00029_NZ_FRCP.. - Region 1 - cyclic-lactone-autoinducer

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Location: 66,328 - 86,924 nt. (total: 20,597 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

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Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000600.1	0.18	RiPP	thurincin H	Bacillus thuringiensis
BGC0000616.1	0.16	RiPP	amylocyclicin	Bacillus velezensis FZB42
BGC0000486.1	0.16	RiPP	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0000528.1	0.16	RiPP	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001743.1	0.16	RiPP	plantaricyclin	Lactobacillus plantarum
BGC0001222.1	0.16	RiPP	acidocin B	Lactobacillus acidophilus
BGC0000491.1	0.16	RiPP	gassericin A	Lactobacillus gasseri
BGC0001551.1	0.16	RiPP	citrulassin E	Streptomyces glaucescens
BGC0001576.1	0.16	RiPP	divamide A	Prochloron didemni
BGC0000620.1	0.15	RiPP	lacticin Q	Lactococcus lactis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000600.1	0.50	RiPP	thurincin H	Bacillus thuringiensis
BGC0000616.1	0.47	RiPP	amylocyclicin	Bacillus velezensis FZB42
BGC0000486.1	0.47	RiPP	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0000528.1	0.46	RiPP	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001743.1	0.46	RiPP	plantaricyclin	Lactobacillus plantarum
BGC0001222.1	0.46	RiPP	acidocin B	Lactobacillus acidophilus
BGC0000491.1	0.46	RiPP	gassericin A	Lactobacillus gasseri
BGC0001551.1	0.46	RiPP	citrulassin E	Streptomyces glaucescens
BGC0001576.1	0.46	RiPP	divamide A	Prochloron didemni
BGC0000620.1	0.46	RiPP	lacticin Q	Lactococcus lactis

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No matches found.

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Detailed TIGRFAM domain annotation

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c00033_NZ_FRCP.. - Region 1 - cyclic-lactone-autoinducer

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Location: 65,060 - 85,771 nt. (total: 20,712 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

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KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001472.1	0.09	RiPP	berninamycin A	Streptomyces bernensis
BGC0000615.1	0.08	RiPP	TP-1161	Nocardiopsis sp. TFS65-07
BGC0000260.1	0.07	Polyketide	prodigiosin	Hahella chejuensis KCTC 2396
BGC0001591.1	0.06	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.06	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0001205.1	0.05	Polyketide	communesin A, communesin B, communesin C, communesin D, communesin E, communesin G, communesin H	Penicillium expansum
BGC0000269.1	0.03	Polyketide, Saccharide	SF2575	Streptomyces sp. SF2575

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001472.1	0.33	RiPP	berninamycin A	Streptomyces bernensis
BGC0000615.1	0.30	RiPP	TP-1161	Nocardiopsis sp. TFS65-07
BGC0000260.1	0.27	Polyketide	prodigiosin	Hahella chejuensis KCTC 2396
BGC0001591.1	0.26	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.26	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0001205.1	0.23	Polyketide	communesin A, communesin B, communesin C, communesin D, communesin E, communesin G, communesin H	Penicillium expansum
BGC0000269.1	0.15	Polyketide, Saccharide	SF2575	Streptomyces sp. SF2575

Similar known gene clusters

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Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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c00039_NZ_FRCP.. - Region 1 - betalactone

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Location: 72,210 - 97,062 nt. (total: 24,853 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

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KnownClusterBlast

Pfam domains

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000719.1	0.22	Saccharide	tobramycin	Streptoalloteichus hindustanus
BGC0000720.1	0.20	Saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0001444.1	0.19	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.19	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0000907.1	0.16	Other	lincomycin	Streptomyces lincolnensis
BGC0000690.1	0.16	Saccharide	hydroxystreptomycin	Streptomyces glaucescens
BGC0000795.1	0.15	Saccharide	S-layer glycan	Aneurinibacillus thermoaerophilus
BGC0000758.1	0.15	Saccharide	capsular polysaccharide	Staphylococcus aureus
BGC0000789.1	0.15	Saccharide	O-antigen	Escherichia coli
BGC0002036.1	0.15	Other	dehydrofosmidomycin	Streptomyces lavendulae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000719.1	0.54	Saccharide	tobramycin	Streptoalloteichus hindustanus
BGC0000720.1	0.52	Saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0001444.1	0.51	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.51	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0000907.1	0.46	Other	lincomycin	Streptomyces lincolnensis
BGC0000690.1	0.46	Saccharide	hydroxystreptomycin	Streptomyces glaucescens
BGC0000795.1	0.46	Saccharide	S-layer glycan	Aneurinibacillus thermoaerophilus
BGC0000758.1	0.46	Saccharide	capsular polysaccharide	Staphylococcus aureus
BGC0000789.1	0.46	Saccharide	O-antigen	Escherichia coli
BGC0002036.1	0.45	Other	dehydrofosmidomycin	Streptomyces lavendulae

Similar known gene clusters

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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c00040_NZ_FRCP.. - Region 1 - NRPS,transAT-PKS

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Location: 37,829 - 129,054 nt. (total: 91,226 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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NRPS/PKS domains

MIBiG comparison

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NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001479.1	0.67	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000145.1	0.58	Polyketide	salinosporamide A	Salinispora tropica
BGC0000979.1	0.57	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.1	0.57	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0001135.1	0.56	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001041.1	0.56	NRP, Polyketide	salinosporamide A	Salinispora tropica CNB-440
BGC0001561.1	0.55	NRP	curacomycin	Streptomyces curacoi
BGC0001132.1	0.53	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.1	0.52	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000971.1	0.52	NRP, Polyketide	cinnabaramide A	Streptomyces cinnabarigriseus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001479.1	0.66	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000389.1	0.66	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001135.1	0.66	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000457.1	0.65	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001767.1	0.65	NRP	salinichelins	Salinispora pacifica CNY331
BGC0001844.1	0.65	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001131.1	0.64	NRP	ambactin	Xenorhabdus miraniensis
BGC0001041.1	0.64	NRP, Polyketide	salinosporamide A	Salinispora tropica CNB-440
BGC0000979.1	0.64	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.1	0.64	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11

Similar known gene clusters

No matches found.

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Detailed Pfam domain annotation

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 37828 - 129054:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ccmal) + (phe - D-phe) + (X - asn - X - val - val - val - leu)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 37828 - 91640:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ccmal) + (phe - D-phe) + (X - asn - X - val - val - val - leu)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 59164 - 129054:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ccmal) + (phe - D-phe) + (X - asn - X - val - val - val - leu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg40_47

PKS_AT (6..284): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 75.0
inactive: 36.7
Methoxymalonyl-CoA: 35.0
Methylmalonyl-CoA: 29.8
Propionyl-CoA: 14.1
2-Methylbutyryl-CoA: 12.4
fatty_acid: 11.5
CHC-CoA: 11.0
Ethylmalonyl-CoA: 9.5
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

ctg40_50

PKS_AT (6..119): pk

ATSignature: (unknown)

No matches above 50%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg40_58

Search NORINE for peptide: strict or relaxed

AMP-binding (283..667): phe

NRPSPredictor2: phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: phe, trp
Single AA prediction:: phe

Stachelhaus prediction details:

Stachelhaus sequence:: DAWTiAAVCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 90% (moderate)

AMP-binding (1305..1686): phe

NRPSPredictor2: phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: phe, trp
Single AA prediction:: phe

Stachelhaus prediction details:

Stachelhaus sequence:: DAWTiAAVCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 90% (moderate)

ctg40_60

Search NORINE for peptide: strict or relaxed

AMP-binding (486..875): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DLpKVGEVfK
Nearest Stachelhaus code:: asn
Stachelhaus code match:: 80% (moderate)

AMP-binding (1510..1905): asn

NRPSPredictor2: asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: asn

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIGEVGK
Nearest Stachelhaus code:: asn
Stachelhaus code match:: 100% (strong)

AMP-binding (2540..2922): X

NRPSPredictor2: val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAwLtGAVlK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 70% (weak)

AMP-binding (3565..3952): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAfWLGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 90% (moderate)

AMP-binding (4587..4974): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAfWLGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 90% (moderate)

AMP-binding (5609..5996): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAfWLGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 90% (moderate)

AMP-binding (6633..7014): leu

NRPSPredictor2: leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: leu

Stachelhaus prediction details:

Stachelhaus sequence:: DAWFLGNVVK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 100% (strong)

c00040_NZ_FRCP.. - Region 2 - NRPS-like

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Location: 152,138 - 193,979 nt. (total: 41,842 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

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Gene details

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NRPS/PKS domains

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KnownClusterBlast

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001184.1	0.27	Other	bacilysin	Bacillus velezensis FZB42
BGC0000888.1	0.27	Other	bacilysin	Bacillus sp. CS93
BGC0001132.1	0.22	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001641.1	0.22	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001479.1	0.22	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000375.1	0.21	NRP	indigoidine	Streptomyces chromofuscus
BGC0001844.1	0.21	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000427.1	0.21	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001166.1	0.21	NRP	HC-toxin	Alternaria jesenskae
BGC0001131.1	0.21	NRP	ambactin	Xenorhabdus miraniensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001184.1	0.60	Other	bacilysin	Bacillus velezensis FZB42
BGC0000888.1	0.60	Other	bacilysin	Bacillus sp. CS93
BGC0001132.1	0.55	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001641.1	0.55	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001479.1	0.55	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000375.1	0.54	NRP	indigoidine	Streptomyces chromofuscus
BGC0001844.1	0.54	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000427.1	0.54	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001166.1	0.54	NRP	HC-toxin	Alternaria jesenskae
BGC0001131.1	0.53	NRP	ambactin	Xenorhabdus miraniensis

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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