Select genomic region:
Overview
16.1
17.1
20.1
27.1
27.2
29.1
33.1
39.1
40.1
40.2

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_FRCP01000014 (original name was: NZ_FRCP01000014.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 16.1 | ranthipeptide | 143,252 | 164,948 | locillomycin | NRP + Polyketide | 14%

NZ_FRCP01000018 (original name was: NZ_FRCP01000018.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 17.1 | ranthipeptide | 25,206 | 46,615 |

NZ_FRCP01000005 (original name was: NZ_FRCP01000005.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 20.1 | NRPS | 1 | 44,170 |

NZ_FRCP01000009 (original name was: NZ_FRCP01000009.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 27.1 | NRPS-like | 49,336 | 92,644 |
Region 27.2 | RRE-containing | 191,476 | 211,766 |

NZ_FRCP01000012 (original name was: NZ_FRCP01000012.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 29.1 | cyclic-lactone-autoinducer | 66,328 | 86,924 |

NZ_FRCP01000015 (original name was: NZ_FRCP01000015.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 33.1 | cyclic-lactone-autoinducer | 65,060 | 85,771 |

NZ_FRCP01000017 (original name was: NZ_FRCP01000017.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 39.1 | betalactone | 72,210 | 97,062 | pseudaminic acid | Other | 33%

NZ_FRCP01000011 (original name was: NZ_FRCP01000011.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 40.1 | transAT-PKS,NRPS | 37,829 | 129,054 |
Region 40.2 | NRPS-like | 152,138 | 193,979 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 16.1 | ranthipeptide | 143,252 | 164,948 | locillomycin | NRP + Polyketide | 14%
Region 17.1 | ranthipeptide | 25,206 | 46,615 |
Region 20.1 | NRPS | 1 | 44,170 |
Region 27.1 | NRPS-like | 49,336 | 92,644 |
Region 27.2 | RRE-containing | 191,476 | 211,766 |
Region 29.1 | cyclic-lactone-autoinducer | 66,328 | 86,924 |
Region 33.1 | cyclic-lactone-autoinducer | 65,060 | 85,771 |
Region 39.1 | betalactone | 72,210 | 97,062 | pseudaminic acid | Other | 33%
Region 40.1 | transAT-PKS,NRPS | 37,829 | 129,054 |
Region 40.2 | NRPS-like | 152,138 | 193,979 |

No secondary metabolite regions were found in these records:
  NZ_FRCP01000042 (original name was: NZ_FRCP01000042.1)
  NZ_FRCP01000040 (original name was: NZ_FRCP01000040.1)
  NZ_FRCP01000038 (original name was: NZ_FRCP01000038.1)
  NZ_FRCP01000037 (original name was: NZ_FRCP01000037.1)
  NZ_FRCP01000034 (original name was: NZ_FRCP01000034.1)
  NZ_FRCP01000033 (original name was: NZ_FRCP01000033.1)
  NZ_FRCP01000032 (original name was: NZ_FRCP01000032.1)
  NZ_FRCP01000041 (original name was: NZ_FRCP01000041.1)
  NZ_FRCP01000030 (original name was: NZ_FRCP01000030.1)
  NZ_FRCP01000036 (original name was: NZ_FRCP01000036.1)
  NZ_FRCP01000029 (original name was: NZ_FRCP01000029.1)
  NZ_FRCP01000026 (original name was: NZ_FRCP01000026.1)
  NZ_FRCP01000025 (original name was: NZ_FRCP01000025.1)
  NZ_FRCP01000024 (original name was: NZ_FRCP01000024.1)
  NZ_FRCP01000023 (original name was: NZ_FRCP01000023.1)
  NZ_FRCP01000008 (original name was: NZ_FRCP01000008.1)
  NZ_FRCP01000027 (original name was: NZ_FRCP01000027.1)
  NZ_FRCP01000043 (original name was: NZ_FRCP01000043.1)
  NZ_FRCP01000007 (original name was: NZ_FRCP01000007.1)
  NZ_FRCP01000004 (original name was: NZ_FRCP01000004.1)
  NZ_FRCP01000006 (original name was: NZ_FRCP01000006.1)
  NZ_FRCP01000031 (original name was: NZ_FRCP01000031.1)
  NZ_FRCP01000028 (original name was: NZ_FRCP01000028.1)
  NZ_FRCP01000010 (original name was: NZ_FRCP01000010.1)
  NZ_FRCP01000045 (original name was: NZ_FRCP01000045.1)
  NZ_FRCP01000013 (original name was: NZ_FRCP01000013.1)
  NZ_FRCP01000016 (original name was: NZ_FRCP01000016.1)
  NZ_FRCP01000019 (original name was: NZ_FRCP01000019.1)
  NZ_FRCP01000020 (original name was: NZ_FRCP01000020.1)
  NZ_FRCP01000044 (original name was: NZ_FRCP01000044.1)
  NZ_FRCP01000039 (original name was: NZ_FRCP01000039.1)
  NZ_FRCP01000035 (original name was: NZ_FRCP01000035.1)
  NZ_FRCP01000021 (original name was: NZ_FRCP01000021.1)
  NZ_FRCP01000022 (original name was: NZ_FRCP01000022.1)

Compact view
c00016_NZ_FRCP.. - Region 1 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 143,252 - 164,948 nt. (total: 21,697 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000600.1 |  | 0.19 | RiPP | thurincin H | Bacillus thuringiensis
BGC0000548.1 |  | 0.16 | RiPP | salivaricin A | Streptococcus salivarius
BGC0000554.1 |  | 0.16 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000556.1 |  | 0.16 | RiPP | streptin | Streptococcus pyogenes
BGC0000547.1 |  | 0.16 | RiPP | salivaricin 9 | Streptococcus salivarius
BGC0001289.1 |  | 0.16 | RiPP | penisin | Paenibacillus ehimensis
BGC0000506.1 |  | 0.16 | RiPP | entianin | Bacillus subtilis subsp. spizizenii
BGC0000502.1 |  | 0.16 | RiPP | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0000517.1 |  | 0.16 | RiPP | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001391.1 |  | 0.16 | RiPP | thusin | Bacillus thuringiensis serovar rongseni

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000600.1 |  | 0.51 | RiPP | thurincin H | Bacillus thuringiensis
BGC0000548.1 |  | 0.47 | RiPP | salivaricin A | Streptococcus salivarius
BGC0000554.1 |  | 0.47 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000556.1 |  | 0.47 | RiPP | streptin | Streptococcus pyogenes
BGC0000547.1 |  | 0.47 | RiPP | salivaricin 9 | Streptococcus salivarius
BGC0001289.1 |  | 0.47 | RiPP | penisin | Paenibacillus ehimensis
BGC0000506.1 |  | 0.47 | RiPP | entianin | Bacillus subtilis subsp. spizizenii
BGC0000502.1 |  | 0.47 | RiPP | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0000517.1 |  | 0.47 | RiPP | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001391.1 |  | 0.46 | RiPP | thusin | Bacillus thuringiensis serovar rongseni

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00017_NZ_FRCP.. - Region 1 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 25,206 - 46,615 nt. (total: 21,410 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000600.1 |  | 0.20 | RiPP | thurincin H | Bacillus thuringiensis
BGC0000521.1 |  | 0.17 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000539.1 |  | 0.17 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0000626.1 |  | 0.17 | RiPP | thuricin | Bacillus thuringiensis
BGC0000498.1 |  | 0.17 | RiPP | bovicin HJ50 | Streptococcus equinus
BGC0000561.1 |  | 0.17 | RiPP | thermophilin 1277 | Streptococcus thermophilus
BGC0000616.1 |  | 0.16 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0000486.1 |  | 0.16 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0001222.1 |  | 0.16 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000491.1 |  | 0.16 | RiPP | gassericin A | Lactobacillus gasseri

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000600.1 |  | 0.52 | RiPP | thurincin H | Bacillus thuringiensis
BGC0000521.1 |  | 0.49 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000539.1 |  | 0.48 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0000626.1 |  | 0.48 | RiPP | thuricin | Bacillus thuringiensis
BGC0000498.1 |  | 0.48 | RiPP | bovicin HJ50 | Streptococcus equinus
BGC0000561.1 |  | 0.48 | RiPP | thermophilin 1277 | Streptococcus thermophilus
BGC0000616.1 |  | 0.47 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0000486.1 |  | 0.47 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0001222.1 |  | 0.47 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000491.1 |  | 0.47 | RiPP | gassericin A | Lactobacillus gasseri

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00020_NZ_FRCP.. - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 44,170 nt. (total: 44,170 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000426.1 |  | 0.39 | NRP | sevadicin | Paenibacillus larvae
BGC0000389.1 |  | 0.32 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000457.1 |  | 0.31 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001671.1 |  | 0.29 | NRP | monobactam | Agrobacterium tumefaciens
BGC0000349.1 |  | 0.29 | NRP | erythrochelin | Saccharopolyspora erythraea NRRL 2338
BGC0001479.1 |  | 0.28 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001502.1 |  | 0.28 | NRP | amonabactin P 750 | Aeromonas hydrophila subsp. hydrophila ATCC 7966
BGC0000351.1 |  | 0.27 | NRP | exochelin | Mycolicibacterium smegmatis
BGC0000430.1 |  | 0.26 | NRP, Polyketide | spumigin E | Nodularia spumigena CCY9414
BGC0000417.1 |  | 0.26 | NRP | rhodochelin | Rhodococcus jostii RHA1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000426.1 |  | 0.71 | NRP | sevadicin | Paenibacillus larvae
BGC0000389.1 |  | 0.66 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000457.1 |  | 0.64 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001671.1 |  | 0.63 | NRP | monobactam | Agrobacterium tumefaciens
BGC0000349.1 |  | 0.62 | NRP | erythrochelin | Saccharopolyspora erythraea NRRL 2338
BGC0001479.1 |  | 0.61 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001502.1 |  | 0.61 | NRP | amonabactin P 750 | Aeromonas hydrophila subsp. hydrophila ATCC 7966
BGC0000351.1 |  | 0.61 | NRP | exochelin | Mycolicibacterium smegmatis
BGC0000430.1 |  | 0.59 | NRP, Polyketide | spumigin E | Nodularia spumigena CCY9414
BGC0000417.1 |  | 0.59 | NRP | rhodochelin | Rhodococcus jostii RHA1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 44170:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (asp - D-glu) + (D-X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg20_10: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (524..926): X
  NRPSPredictor2: asp, asn, glu, gln, aad
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAKDvGVdvK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      70% (weak)
ctg20_11: pk - asp - glu
  Search NORINE for peptide: strict or relaxed
  CAL_domain (179..493): pk
  minowa: fatty_acid
  Prediction, score:
    fatty_acid: 88.2
    shikimic_acid: 0.0
    NH2: 0.0
    Acetyl-CoA: 0.0
    AHBA: 0.0
  AMP-binding (1142..1546): asp
  NRPSPredictor2: asp
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      asp, asn
    Single AA prediction:
      asp
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKVGHIGK
    Nearest Stachelhaus code:
      asp
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2187..2597): glu
  NRPSPredictor2: glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      glu, gln
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAKDLGVVDK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      100% (strong)

c00027_NZ_FRCP.. - Region 1 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 49,336 - 92,644 nt. (total: 43,309 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000427.1 |  |  | 0.65 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  |  | 0.65 | NRP | indigoidine | Streptomyces chromofuscus
BGC0002002.1 |  |  | 0.59 | NRP | 1,6-phenazinedimethanol, fontizine A | Serratia fonticola
BGC0000426.1 |  |  | 0.58 | NRP | sevadicin | Paenibacillus larvae
BGC0000465.1 |  |  | 0.57 | NRP | xenortide A, xenortide B, xenortide C, xenortide D | Xenorhabdus nematophila ATCC 19061
BGC0000389.1 |  |  | 0.56 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001527.1 |  |  | 0.55 | Other | basidioferrin | Gelatoporia subvermispora
BGC0000921.1 |  |  | 0.55 | Other (Shikimate-derived), Polyketide, NRP | promysalin | Pseudomonas putida
BGC0000348.1 |  |  | 0.54 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0001050.1 |  |  | 0.54 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.66 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.66 | NRP | indigoidine | Streptomyces chromofuscus
BGC0002002.1 |  | 0.63 | NRP | 1,6-phenazinedimethanol, fontizine A | Serratia fonticola
BGC0000426.1 |  | 0.62 | NRP | sevadicin | Paenibacillus larvae
BGC0000465.1 |  | 0.62 | NRP | xenortide A, xenortide B, xenortide C, xenortide D | Xenorhabdus nematophila ATCC 19061
BGC0000389.1 |  | 0.61 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001527.1 |  | 0.61 | Other | basidioferrin | Gelatoporia subvermispora
BGC0000921.1 |  | 0.61 | Other (Shikimate-derived), Polyketide, NRP | promysalin | Pseudomonas putida
BGC0000348.1 |  | 0.61 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0001050.1 |  | 0.61 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 49335 - 92644:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 49335 - 90648:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 50829 - 92644:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg27_72: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (15..403): X
  NRPSPredictor2: hydrophobic-aromatic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DiWeLtadDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      50% (weak)
ctg27_73: thr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (18..422): thr
  NRPSPredictor2: thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      thr
    Single AA prediction:
      thr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DYWSVGMVHK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      100% (strong)

c00027_NZ_FRCP.. - Region 2 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 191,476 - 211,766 nt. (total: 20,291 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001859.1 |  | 0.24 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000904.1 |  | 0.21 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0001496.1 |  | 0.17 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0000504.1 |  | 0.16 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001576.1 |  | 0.16 | RiPP | divamide A | Prochloron didemni
BGC0000500.1 |  | 0.16 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000554.1 |  | 0.16 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000558.1 |  | 0.16 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001526.1 |  | 0.16 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0001120.1 |  | 0.16 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001859.1 |  | 0.57 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000904.1 |  | 0.54 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0001496.1 |  | 0.49 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0000504.1 |  | 0.47 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001576.1 |  | 0.46 | RiPP | divamide A | Prochloron didemni
BGC0000500.1 |  | 0.46 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000554.1 |  | 0.46 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000558.1 |  | 0.46 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001526.1 |  | 0.46 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0001120.1 |  | 0.46 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00029_NZ_FRCP.. - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 66,328 - 86,924 nt. (total: 20,597 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000600.1 |  | 0.18 | RiPP | thurincin H | Bacillus thuringiensis
BGC0000616.1 |  | 0.16 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0000486.1 |  | 0.16 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0000528.1 |  | 0.16 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001743.1 |  | 0.16 | RiPP | plantaricyclin | Lactobacillus plantarum
BGC0001222.1 |  | 0.16 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000491.1 |  | 0.16 | RiPP | gassericin A | Lactobacillus gasseri
BGC0001551.1 |  | 0.16 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0001576.1 |  | 0.16 | RiPP | divamide A | Prochloron didemni
BGC0000620.1 |  | 0.15 | RiPP | lacticin Q | Lactococcus lactis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000600.1 |  | 0.50 | RiPP | thurincin H | Bacillus thuringiensis
BGC0000616.1 |  | 0.47 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0000486.1 |  | 0.47 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0000528.1 |  | 0.46 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001743.1 |  | 0.46 | RiPP | plantaricyclin | Lactobacillus plantarum
BGC0001222.1 |  | 0.46 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000491.1 |  | 0.46 | RiPP | gassericin A | Lactobacillus gasseri
BGC0001551.1 |  | 0.46 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0001576.1 |  | 0.46 | RiPP | divamide A | Prochloron didemni
BGC0000620.1 |  | 0.46 | RiPP | lacticin Q | Lactococcus lactis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00033_NZ_FRCP.. - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 65,060 - 85,771 nt. (total: 20,712 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001472.1 |  | 0.09 | RiPP | berninamycin A | Streptomyces bernensis
BGC0000615.1 |  | 0.08 | RiPP | TP-1161 | Nocardiopsis sp. TFS65-07
BGC0000260.1 |  | 0.07 | Polyketide | prodigiosin | Hahella chejuensis KCTC 2396
BGC0001591.1 |  | 0.06 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.06 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0001205.1 |  | 0.05 | Polyketide | communesin A, communesin B, communesin C, communesin D, communesin E, communesin G, communesin H | Penicillium expansum
BGC0000269.1 |  | 0.03 | Polyketide, Saccharide | SF2575 | Streptomyces sp. SF2575

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001472.1 |  | 0.33 | RiPP | berninamycin A | Streptomyces bernensis
BGC0000615.1 |  | 0.30 | RiPP | TP-1161 | Nocardiopsis sp. TFS65-07
BGC0000260.1 |  | 0.27 | Polyketide | prodigiosin | Hahella chejuensis KCTC 2396
BGC0001591.1 |  | 0.26 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.26 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0001205.1 |  | 0.23 | Polyketide | communesin A, communesin B, communesin C, communesin D, communesin E, communesin G, communesin H | Penicillium expansum
BGC0000269.1 |  | 0.15 | Polyketide, Saccharide | SF2575 | Streptomyces sp. SF2575

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00039_NZ_FRCP.. - Region 1 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 72,210 - 97,062 nt. (total: 24,853 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000719.1 |  | 0.22 | Saccharide | tobramycin | Streptoalloteichus hindustanus
BGC0000720.1 |  | 0.20 | Saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0001444.1 |  | 0.19 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001538.1 |  | 0.19 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0000907.1 |  | 0.16 | Other | lincomycin | Streptomyces lincolnensis
BGC0000690.1 |  | 0.16 | Saccharide | hydroxystreptomycin | Streptomyces glaucescens
BGC0000795.1 |  | 0.15 | Saccharide | S-layer glycan | Aneurinibacillus thermoaerophilus
BGC0000758.1 |  | 0.15 | Saccharide | capsular polysaccharide | Staphylococcus aureus
BGC0000789.1 |  | 0.15 | Saccharide | O-antigen | Escherichia coli
BGC0002036.1 |  | 0.15 | Other | dehydrofosmidomycin | Streptomyces lavendulae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000719.1 |  | 0.54 | Saccharide | tobramycin | Streptoalloteichus hindustanus
BGC0000720.1 |  | 0.52 | Saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0001444.1 |  | 0.51 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001538.1 |  | 0.51 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0000907.1 |  | 0.46 | Other | lincomycin | Streptomyces lincolnensis
BGC0000690.1 |  | 0.46 | Saccharide | hydroxystreptomycin | Streptomyces glaucescens
BGC0000795.1 |  | 0.46 | Saccharide | S-layer glycan | Aneurinibacillus thermoaerophilus
BGC0000758.1 |  | 0.46 | Saccharide | capsular polysaccharide | Staphylococcus aureus
BGC0000789.1 |  | 0.46 | Saccharide | O-antigen | Escherichia coli
BGC0002036.1 |  | 0.45 | Other | dehydrofosmidomycin | Streptomyces lavendulae

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00040_NZ_FRCP.. - Region 1 - NRPS,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 37,829 - 129,054 nt. (total: 91,226 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001479.1 |  |  | 0.67 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000145.1 |  |  | 0.58 | Polyketide | salinosporamide A | Salinispora tropica
BGC0000979.1 |  |  | 0.57 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  |  | 0.57 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0001135.1 |  |  | 0.56 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001041.1 |  |  | 0.56 | NRP, Polyketide | salinosporamide A | Salinispora tropica CNB-440
BGC0001561.1 |  |  | 0.55 | NRP | curacomycin | Streptomyces curacoi
BGC0001132.1 |  |  | 0.53 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.1 |  |  | 0.52 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000971.1 |  |  | 0.52 | NRP, Polyketide | cinnabaramide A | Streptomyces cinnabarigriseus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001479.1 |  | 0.66 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000389.1 |  | 0.66 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001135.1 |  | 0.66 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000457.1 |  | 0.65 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001767.1 |  | 0.65 | NRP | salinichelins | Salinispora pacifica CNY331
BGC0001844.1 |  | 0.65 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001131.1 |  | 0.64 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001041.1 |  | 0.64 | NRP, Polyketide | salinosporamide A | Salinispora tropica CNB-440
BGC0000979.1 |  | 0.64 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  | 0.64 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 37828 - 129054:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ccmal) + (phe - D-phe) + (X - asn - X - val - val - val - leu)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 37828 - 91640:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ccmal) + (phe - D-phe) + (X - asn - X - val - val - val - leu)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 59164 - 129054:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ccmal) + (phe - D-phe) + (X - asn - X - val - val - val - leu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg40_47: mal
  PKS_AT (6..284): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 66.7%
    inactive: 58.3%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 75.0
    inactive: 36.7
    Methoxymalonyl-CoA: 35.0
    Methylmalonyl-CoA: 29.8
    Propionyl-CoA: 14.1
    2-Methylbutyryl-CoA: 12.4
    fatty_acid: 11.5
    CHC-CoA: 11.0
    Ethylmalonyl-CoA: 9.5
    trans-1,2-CPDA: 0.0
    Isobutyryl-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
ctg40_50: pk
  PKS_AT (6..119): pk
  ATSignature: (unknown)
  No matches above 50%
  minowa: trans-1,2-CPDA
  Prediction, score:
    trans-1,2-CPDA: 0.0
    inactive: 0.0
    fatty_acid: 0.0
    Propionyl-CoA: 0.0
    Methylmalonyl-CoA: 0.0
    Methoxymalonyl-CoA: 0.0
    Malonyl-CoA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg40_58: phe - phe
  Search NORINE for peptide: strict or relaxed
  AMP-binding (283..667): phe
  NRPSPredictor2: phe
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      phe, trp
    Single AA prediction:
      phe
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWTiAAVCK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      90% (moderate)
  AMP-binding (1305..1686): phe
  NRPSPredictor2: phe
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      phe, trp
    Single AA prediction:
      phe
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWTiAAVCK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      90% (moderate)
ctg40_60: X - asn - X - val - val - val - leu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (486..875): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLpKVGEVfK
    Nearest Stachelhaus code:
      asn
    Stachelhaus code match:
      80% (moderate)
  AMP-binding (1510..1905): asn
  NRPSPredictor2: asn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      asp, asn
    Single AA prediction:
      asn
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKIGEVGK
    Nearest Stachelhaus code:
      asn
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2540..2922): X
  NRPSPredictor2: val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAwLtGAVlK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      70% (weak)
  AMP-binding (3565..3952): val
  NRPSPredictor2: val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      val
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAfWLGGTFK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      90% (moderate)
  AMP-binding (4587..4974): val
  NRPSPredictor2: val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      val
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAfWLGGTFK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      90% (moderate)
  AMP-binding (5609..5996): val
  NRPSPredictor2: val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      val
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAfWLGGTFK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      90% (moderate)
  AMP-binding (6633..7014): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWFLGNVVK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      100% (strong)

c00040_NZ_FRCP.. - Region 2 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 152,138 - 193,979 nt. (total: 41,842 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001184.1 |  | 0.27 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000888.1 |  | 0.27 | Other | bacilysin | Bacillus sp. CS93
BGC0001132.1 |  | 0.22 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001641.1 |  | 0.22 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001479.1 |  | 0.22 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000375.1 |  | 0.21 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001844.1 |  | 0.21 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000427.1 |  | 0.21 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001166.1 |  | 0.21 | NRP | HC-toxin | Alternaria jesenskae
BGC0001131.1 |  | 0.21 | NRP | ambactin | Xenorhabdus miraniensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001184.1 |  | 0.60 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000888.1 |  | 0.60 | Other | bacilysin | Bacillus sp. CS93
BGC0001132.1 |  | 0.55 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001641.1 |  | 0.55 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001479.1 |  | 0.55 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000375.1 |  | 0.54 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001844.1 |  | 0.54 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000427.1 |  | 0.54 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001166.1 |  | 0.54 | NRP | HC-toxin | Alternaria jesenskae
BGC0001131.1 |  | 0.53 | NRP | ambactin | Xenorhabdus miraniensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names