GCF_006539145.1_ASM653914v1_genomic - 5 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_BJML01000001 (original name was: NZ_BJML01000001.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	betalactone	727,275	755,571	microansamycin	Polyketide	7%

NZ_BJML01000002 (original name was: NZ_BJML01000002.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 2.1	NRPS-like,NAPAA	207,246	265,523	qinichelins	NRP	11%
Region 2.2	T3PKS	380,782	421,876	herboxidiene	Polyketide	2%

NZ_BJML01000006 (original name was: NZ_BJML01000006.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 6.1	terpene	83,125	103,994	carotenoid	Terpene	21%

NZ_BJML01000009 (original name was: NZ_BJML01000009.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 9.1	NRPS	138,440	188,427	coelichelin	NRP	45%

No secondary metabolite regions were found in these records:: NZ_BJML01000003 (original name was: NZ_BJML01000003.1); NZ_BJML01000004 (original name was: NZ_BJML01000004.1); NZ_BJML01000005 (original name was: NZ_BJML01000005.1); NZ_BJML01000007 (original name was: NZ_BJML01000007.1); NZ_BJML01000008 (original name was: NZ_BJML01000008.1); NZ_BJML01000010 (original name was: NZ_BJML01000010.1); NZ_BJML01000011 (original name was: NZ_BJML01000011.1); NZ_BJML01000012 (original name was: NZ_BJML01000012.1); NZ_BJML01000013 (original name was: NZ_BJML01000013.1); NZ_BJML01000014 (original name was: NZ_BJML01000014.1); NZ_BJML01000015 (original name was: NZ_BJML01000015.1); NZ_BJML01000016 (original name was: NZ_BJML01000016.1); NZ_BJML01000017 (original name was: NZ_BJML01000017.1); NZ_BJML01000018 (original name was: NZ_BJML01000018.1); NZ_BJML01000019 (original name was: NZ_BJML01000019.1); NZ_BJML01000020 (original name was: NZ_BJML01000020.1); NZ_BJML01000021 (original name was: NZ_BJML01000021.1); NZ_BJML01000022 (original name was: NZ_BJML01000022.1); NZ_BJML01000023 (original name was: NZ_BJML01000023.1); NZ_BJML01000024 (original name was: NZ_BJML01000024.1); NZ_BJML01000025 (original name was: NZ_BJML01000025.1)

Compact view

c00001_NZ_BJML.. - Region 1 - betalactone

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Location: 727,275 - 755,571 nt. (total: 28,297 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000649.1	0.22	Terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001935.1	0.19	Other	3,7-dihydroxytropolone	Streptomyces cyaneofuscatus
BGC0001487.1	0.19	Other	3,7-dihydroxytropolone	Streptomyces cyaneofuscatus
BGC0000698.1	0.18	Saccharide	hygromycin A	Streptomyces hygroscopicus
BGC0001483.1	0.18	Other	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0001910.1	0.17	Terpene	cyslabdan	Streptomyces cyslabdanicus
BGC0001911.1	0.17	Terpene	raimonol	Streptomyces anulatus
BGC0000936.1	0.17	Other	pyocyanine	Pseudomonas aeruginosa PAO1
BGC0000286.1	0.17	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0000633.1	0.17	Terpene	carotenoid	Streptomyces avermitilis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000649.1	0.55	Terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001935.1	0.51	Other	3,7-dihydroxytropolone	Streptomyces cyaneofuscatus
BGC0001487.1	0.51	Other	3,7-dihydroxytropolone	Streptomyces cyaneofuscatus
BGC0000698.1	0.49	Saccharide	hygromycin A	Streptomyces hygroscopicus
BGC0001483.1	0.49	Other	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0001910.1	0.49	Terpene	cyslabdan	Streptomyces cyslabdanicus
BGC0001911.1	0.49	Terpene	raimonol	Streptomyces anulatus
BGC0000936.1	0.48	Other	pyocyanine	Pseudomonas aeruginosa PAO1
BGC0000286.1	0.48	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0000633.1	0.48	Terpene	carotenoid	Streptomyces avermitilis

Similar known gene clusters

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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c00002_NZ_BJML.. - Region 1 - NAPAA,NRPS-like

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Location: 207,246 - 265,523 nt. (total: 58,278 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
NAPAA: (AMP-binding and PP-binding and TIGR02353)

Legend:

core biosynthetic genes

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TTA codons

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000375.1	0.41	NRP	indigoidine	Streptomyces chromofuscus
BGC0001900.1	0.38	NRP	fragin	Burkholderia cenocepacia H111
BGC0001168.1	0.38	NRP	livipeptin	Streptomyces lividans 1326
BGC0000410.1	0.36	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001758.1	0.35	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000928.1	0.35	Other	T3 toxin	Cylindrospermopsis raciborskii T3
BGC0000188.1	0.35	Alkaloid	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0001844.1	0.35	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001131.1	0.35	NRP	ambactin	Xenorhabdus miraniensis
BGC0001641.1	0.35	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001399.1	0.60	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0000410.1	0.57	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001168.1	0.55	NRP	livipeptin	Streptomyces lividans 1326
BGC0001900.1	0.54	NRP	fragin	Burkholderia cenocepacia H111
BGC0000375.1	0.54	NRP	indigoidine	Streptomyces chromofuscus
BGC0000427.1	0.54	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000389.1	0.54	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001627.1	0.53	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0001964.1	0.52	Polyketide	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0000343.1	0.52	NRP	enterobactin	Pseudomonas sp. J465

Similar known gene clusters

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Legend

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 207245 - 265523:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 207245 - 246588:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 231584 - 265523:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg2_201

Search NORINE for peptide: strict or relaxed

AMP-binding (11..442): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: ltAVagVsIK
Nearest Stachelhaus code:: pro
Stachelhaus code match:: 50% (weak)

ctg2_220

Search NORINE for peptide: strict or relaxed

AMP-binding (29..416): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAESIGtVvK
Nearest Stachelhaus code:: lys
Stachelhaus code match:: 80% (moderate)

c00002_NZ_BJML.. - Region 2 - T3PKS

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Location: 380,782 - 421,876 nt. (total: 41,095 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001962.1	0.35	Polyketide	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0001938.1	0.35	Polyketide	entotheonella	Candidatus Entotheonella serta
BGC0000282.1	0.33	Polyketide	alkylresorcinol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001077.1	0.26	Terpene, Polyketide	alkyl-O-dihydrogeranyl-methoxyhydroquinones	Actinoplanes missouriensis 431
BGC0001831.1	0.23	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001904.1	0.22	Polyketide	fluostatin	Micromonospora rosaria
BGC0001334.1	0.21	Alkaloid	caldoniamide A, cladoniamide B, cladoniamide C7, cladoniamide D, cladoniamide E, cladoniamide F, cladoniamide G	Streptomyces uncialis
BGC0001177.1	0.21	Polyketide	mensacaricin	Streptomyces bottropensis
BGC0001687.1	0.20	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSL12
BGC0001333.1	0.20	Alkaloid	BE-54017	uncultured bacterium AB1650

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001962.1	0.68	Polyketide	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0001938.1	0.68	Polyketide	entotheonella	Candidatus Entotheonella serta
BGC0000282.1	0.66	Polyketide	alkylresorcinol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001077.1	0.60	Terpene, Polyketide	alkyl-O-dihydrogeranyl-methoxyhydroquinones	Actinoplanes missouriensis 431
BGC0001831.1	0.56	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001904.1	0.54	Polyketide	fluostatin	Micromonospora rosaria
BGC0001334.1	0.53	Alkaloid	caldoniamide A, cladoniamide B, cladoniamide C7, cladoniamide D, cladoniamide E, cladoniamide F, cladoniamide G	Streptomyces uncialis
BGC0001177.1	0.53	Polyketide	mensacaricin	Streptomyces bottropensis
BGC0001687.1	0.53	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSL12
BGC0001333.1	0.52	Alkaloid	BE-54017	uncultured bacterium AB1650

Similar known gene clusters

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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c00006_NZ_BJML.. - Region 1 - terpene

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Location: 83,125 - 103,994 nt. (total: 20,870 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

Legend:

core biosynthetic genes

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other genes

resistance

TTA codons

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000637.1	0.26	Terpene	carotenoid	Corynebacterium glutamicum
BGC0000650.1	0.25	Terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000648.1	0.22	Terpene	carotenoid	Myxococcus xanthus
BGC0000644.1	0.22	Terpene	carotenoid	Dietzia sp. CQ4
BGC0000646.1	0.20	Terpene	β-carotein	uncultured bacterium
BGC0000645.1	0.18	Terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000649.1	0.17	Terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000764.1	0.16	Saccharide	exopolysaccharide	Lactococcus lactis
BGC0000765.1	0.16	Saccharide	exopolysaccharide	Lactobacillus johnsonii
BGC0000767.1	0.16	Saccharide	exopolysaccharide	Lactobacillus johnsonii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000637.1	0.59	Terpene	carotenoid	Corynebacterium glutamicum
BGC0000650.1	0.59	Terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000648.1	0.55	Terpene	carotenoid	Myxococcus xanthus
BGC0000644.1	0.55	Terpene	carotenoid	Dietzia sp. CQ4
BGC0000646.1	0.53	Terpene	β-carotein	uncultured bacterium
BGC0000645.1	0.50	Terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000649.1	0.48	Terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000764.1	0.47	Saccharide	exopolysaccharide	Lactococcus lactis
BGC0000765.1	0.46	Saccharide	exopolysaccharide	Lactobacillus johnsonii
BGC0000767.1	0.46	Saccharide	exopolysaccharide	Lactobacillus johnsonii

Similar known gene clusters

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

Selected features only

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c00009_NZ_BJML.. - Region 1 - NRPS

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Location: 138,440 - 188,427 nt. (total: 49,988 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000389.1	0.35	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001050.1	0.34	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000417.1	0.33	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0001890.1	0.32	NRP	amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4	Vibrio campbellii ATCC BAA-1116
BGC0000457.1	0.31	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001615.1	0.31	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001185.1	0.30	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000401.1	0.30	NRP	paenibactin	Paenibacillus elgii B69
BGC0000351.1	0.28	NRP	exochelin	Mycolicibacterium smegmatis
BGC0001833.1	0.28	NRP	icosalide A, icosalide B	Burkholderia gladioli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000389.1	0.68	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001050.1	0.67	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000417.1	0.66	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0001890.1	0.65	NRP	amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4	Vibrio campbellii ATCC BAA-1116
BGC0000457.1	0.65	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001615.1	0.64	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001185.1	0.64	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000401.1	0.63	NRP	paenibactin	Paenibacillus elgii B69
BGC0000351.1	0.62	NRP	exochelin	Mycolicibacterium smegmatis
BGC0001833.1	0.61	NRP	icosalide A, icosalide B	Burkholderia gladioli

Similar known gene clusters

Module view

Legend

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 138439 - 188427:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (orn - ser) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg9_156

Search NORINE for peptide: strict or relaxed

AMP-binding (458..857): orn

NRPSPredictor2: orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: orn, lys, arg
Small clusters prediction:: orn, horn
Single AA prediction:: orn

Stachelhaus prediction details:

Stachelhaus sequence:: DINYWGGIGK
Nearest Stachelhaus code:: orn
Stachelhaus code match:: 100% (strong)

AMP-binding (1461..1817): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHVSLVDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

ctg9_157

Search NORINE for peptide: strict or relaxed

AMP-binding (1232..1634): X

NRPSPredictor2: hydrophilic

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAWdsGLInK
Nearest Stachelhaus code:: gln
Stachelhaus code match:: 70% (weak)