Select genomic region:
Overview
1.1
2.1
2.2
6.1
9.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_BJML01000001 (original name was: NZ_BJML01000001.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | betalactone | 727,275 | 755,571 | microansamycin | Polyketide | 7%

NZ_BJML01000002 (original name was: NZ_BJML01000002.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | NRPS-like,NAPAA | 207,246 | 265,523 | qinichelins | NRP | 11%
Region 2.2 | T3PKS | 380,782 | 421,876 | herboxidiene | Polyketide | 2%

NZ_BJML01000006 (original name was: NZ_BJML01000006.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 6.1 | terpene | 83,125 | 103,994 | carotenoid | Terpene | 21%

NZ_BJML01000009 (original name was: NZ_BJML01000009.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 9.1 | NRPS | 138,440 | 188,427 | coelichelin | NRP | 45%

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | betalactone | 727,275 | 755,571 | microansamycin | Polyketide | 7%
Region 2.1 | NRPS-like,NAPAA | 207,246 | 265,523 | qinichelins | NRP | 11%
Region 2.2 | T3PKS | 380,782 | 421,876 | herboxidiene | Polyketide | 2%
Region 6.1 | terpene | 83,125 | 103,994 | carotenoid | Terpene | 21%
Region 9.1 | NRPS | 138,440 | 188,427 | coelichelin | NRP | 45%

No secondary metabolite regions were found in these records:
  NZ_BJML01000003 (original name was: NZ_BJML01000003.1)
  NZ_BJML01000004 (original name was: NZ_BJML01000004.1)
  NZ_BJML01000005 (original name was: NZ_BJML01000005.1)
  NZ_BJML01000007 (original name was: NZ_BJML01000007.1)
  NZ_BJML01000008 (original name was: NZ_BJML01000008.1)
  NZ_BJML01000010 (original name was: NZ_BJML01000010.1)
  NZ_BJML01000011 (original name was: NZ_BJML01000011.1)
  NZ_BJML01000012 (original name was: NZ_BJML01000012.1)
  NZ_BJML01000013 (original name was: NZ_BJML01000013.1)
  NZ_BJML01000014 (original name was: NZ_BJML01000014.1)
  NZ_BJML01000015 (original name was: NZ_BJML01000015.1)
  NZ_BJML01000016 (original name was: NZ_BJML01000016.1)
  NZ_BJML01000017 (original name was: NZ_BJML01000017.1)
  NZ_BJML01000018 (original name was: NZ_BJML01000018.1)
  NZ_BJML01000019 (original name was: NZ_BJML01000019.1)
  NZ_BJML01000020 (original name was: NZ_BJML01000020.1)
  NZ_BJML01000021 (original name was: NZ_BJML01000021.1)
  NZ_BJML01000022 (original name was: NZ_BJML01000022.1)
  NZ_BJML01000023 (original name was: NZ_BJML01000023.1)
  NZ_BJML01000024 (original name was: NZ_BJML01000024.1)
  NZ_BJML01000025 (original name was: NZ_BJML01000025.1)

Compact view
c00001_NZ_BJML.. - Region 1 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 727,275 - 755,571 nt. (total: 28,297 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000649.1 |  | 0.22 | Terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001935.1 |  | 0.19 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0001487.1 |  | 0.19 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0000698.1 |  | 0.18 | Saccharide | hygromycin A | Streptomyces hygroscopicus
BGC0001483.1 |  | 0.18 | Other | 5-isoprenylindole-3-carboxylate β-D-glycosyl ester | Streptomyces sp. RM-5-8
BGC0001910.1 |  | 0.17 | Terpene | cyslabdan | Streptomyces cyslabdanicus
BGC0001911.1 |  | 0.17 | Terpene | raimonol | Streptomyces anulatus
BGC0000936.1 |  | 0.17 | Other | pyocyanine | Pseudomonas aeruginosa PAO1
BGC0000286.1 |  | 0.17 | Polyketide | viguiepinol | Streptomyces sp. KO-3988
BGC0000633.1 |  | 0.17 | Terpene | carotenoid | Streptomyces avermitilis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000649.1 |  | 0.55 | Terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001935.1 |  | 0.51 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0001487.1 |  | 0.51 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0000698.1 |  | 0.49 | Saccharide | hygromycin A | Streptomyces hygroscopicus
BGC0001483.1 |  | 0.49 | Other | 5-isoprenylindole-3-carboxylate β-D-glycosyl ester | Streptomyces sp. RM-5-8
BGC0001910.1 |  | 0.49 | Terpene | cyslabdan | Streptomyces cyslabdanicus
BGC0001911.1 |  | 0.49 | Terpene | raimonol | Streptomyces anulatus
BGC0000936.1 |  | 0.48 | Other | pyocyanine | Pseudomonas aeruginosa PAO1
BGC0000286.1 |  | 0.48 | Polyketide | viguiepinol | Streptomyces sp. KO-3988
BGC0000633.1 |  | 0.48 | Terpene | carotenoid | Streptomyces avermitilis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00002_NZ_BJML.. - Region 1 - NAPAA,NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 207,246 - 265,523 nt. (total: 58,278 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
NAPAA: (AMP-binding and PP-binding and TIGR02353)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | NAPAA | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000375.1 |  |  | 0.41 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001900.1 |  |  | 0.38 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001168.1 |  |  | 0.38 | NRP | livipeptin | Streptomyces lividans 1326
BGC0000410.1 |  |  | 0.36 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001758.1 |  |  | 0.35 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000928.1 |  |  | 0.35 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  |  | 0.35 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0001844.1 |  |  | 0.35 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001131.1 |  |  | 0.35 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001641.1 |  |  | 0.35 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001399.1 |  | 0.60 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000410.1 |  | 0.57 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001168.1 |  | 0.55 | NRP | livipeptin | Streptomyces lividans 1326
BGC0001900.1 |  | 0.54 | NRP | fragin | Burkholderia cenocepacia H111
BGC0000375.1 |  | 0.54 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000427.1 |  | 0.54 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000389.1 |  | 0.54 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001627.1 |  | 0.53 | NRP | isonitrile lipopeptides | Mycobacterium tuberculosis H37Rv
BGC0001964.1 |  | 0.52 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0000343.1 |  | 0.52 | NRP | enterobactin | Pseudomonas sp. J465

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 207245 - 265523:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 207245 - 246588:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 231584 - 265523:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg2_201: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (11..442): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      ltAVagVsIK
    Nearest Stachelhaus code:
      pro
    Stachelhaus code match:
      50% (weak)
ctg2_220: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (29..416): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAESIGtVvK
    Nearest Stachelhaus code:
      lys
    Stachelhaus code match:
      80% (moderate)

c00002_NZ_BJML.. - Region 2 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 380,782 - 421,876 nt. (total: 41,095 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001962.1 |  | 0.35 | Polyketide | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0001938.1 |  | 0.35 | Polyketide | entotheonella | Candidatus Entotheonella serta
BGC0000282.1 |  | 0.33 | Polyketide | alkylresorcinol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001077.1 |  | 0.26 | Terpene, Polyketide | alkyl-O-dihydrogeranyl-methoxyhydroquinones | Actinoplanes missouriensis 431
BGC0001831.1 |  | 0.23 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001904.1 |  | 0.22 | Polyketide | fluostatin | Micromonospora rosaria
BGC0001334.1 |  | 0.21 | Alkaloid | caldoniamide A, cladoniamide B, cladoniamide C7, cladoniamide D, cladoniamide E, cladoniamide F, cladoniamide G | Streptomyces uncialis
BGC0001177.1 |  | 0.21 | Polyketide | mensacaricin | Streptomyces bottropensis
BGC0001687.1 |  | 0.20 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSL12
BGC0001333.1 |  | 0.20 | Alkaloid | BE-54017 | uncultured bacterium AB1650

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001962.1 |  | 0.68 | Polyketide | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0001938.1 |  | 0.68 | Polyketide | entotheonella | Candidatus Entotheonella serta
BGC0000282.1 |  | 0.66 | Polyketide | alkylresorcinol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001077.1 |  | 0.60 | Terpene, Polyketide | alkyl-O-dihydrogeranyl-methoxyhydroquinones | Actinoplanes missouriensis 431
BGC0001831.1 |  | 0.56 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001904.1 |  | 0.54 | Polyketide | fluostatin | Micromonospora rosaria
BGC0001334.1 |  | 0.53 | Alkaloid | caldoniamide A, cladoniamide B, cladoniamide C7, cladoniamide D, cladoniamide E, cladoniamide F, cladoniamide G | Streptomyces uncialis
BGC0001177.1 |  | 0.53 | Polyketide | mensacaricin | Streptomyces bottropensis
BGC0001687.1 |  | 0.53 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSL12
BGC0001333.1 |  | 0.52 | Alkaloid | BE-54017 | uncultured bacterium AB1650

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00006_NZ_BJML.. - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 83,125 - 103,994 nt. (total: 20,870 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000637.1 |  | 0.26 | Terpene | carotenoid | Corynebacterium glutamicum
BGC0000650.1 |  | 0.25 | Terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000648.1 |  | 0.22 | Terpene | carotenoid | Myxococcus xanthus
BGC0000644.1 |  | 0.22 | Terpene | carotenoid | Dietzia sp. CQ4
BGC0000646.1 |  | 0.20 | Terpene | β-carotein | uncultured bacterium
BGC0000645.1 |  | 0.18 | Terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000649.1 |  | 0.17 | Terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000764.1 |  | 0.16 | Saccharide | exopolysaccharide | Lactococcus lactis
BGC0000765.1 |  | 0.16 | Saccharide | exopolysaccharide | Lactobacillus johnsonii
BGC0000767.1 |  | 0.16 | Saccharide | exopolysaccharide | Lactobacillus johnsonii

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000637.1 |  | 0.59 | Terpene | carotenoid | Corynebacterium glutamicum
BGC0000650.1 |  | 0.59 | Terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000648.1 |  | 0.55 | Terpene | carotenoid | Myxococcus xanthus
BGC0000644.1 |  | 0.55 | Terpene | carotenoid | Dietzia sp. CQ4
BGC0000646.1 |  | 0.53 | Terpene | β-carotein | uncultured bacterium
BGC0000645.1 |  | 0.50 | Terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000649.1 |  | 0.48 | Terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000764.1 |  | 0.47 | Saccharide | exopolysaccharide | Lactococcus lactis
BGC0000765.1 |  | 0.46 | Saccharide | exopolysaccharide | Lactobacillus johnsonii
BGC0000767.1 |  | 0.46 | Saccharide | exopolysaccharide | Lactobacillus johnsonii

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00009_NZ_BJML.. - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 138,440 - 188,427 nt. (total: 49,988 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000389.1 |  | 0.35 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001050.1 |  | 0.34 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0000417.1 |  | 0.33 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001890.1 |  | 0.32 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116
BGC0000457.1 |  | 0.31 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001615.1 |  | 0.31 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001185.1 |  | 0.30 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0000401.1 |  | 0.30 | NRP | paenibactin | Paenibacillus elgii B69
BGC0000351.1 |  | 0.28 | NRP | exochelin | Mycolicibacterium smegmatis
BGC0001833.1 |  | 0.28 | NRP | icosalide A, icosalide B | Burkholderia gladioli

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000389.1 |  | 0.68 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001050.1 |  | 0.67 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0000417.1 |  | 0.66 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001890.1 |  | 0.65 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116
BGC0000457.1 |  | 0.65 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001615.1 |  | 0.64 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001185.1 |  | 0.64 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0000401.1 |  | 0.63 | NRP | paenibactin | Paenibacillus elgii B69
BGC0000351.1 |  | 0.62 | NRP | exochelin | Mycolicibacterium smegmatis
BGC0001833.1 |  | 0.61 | NRP | icosalide A, icosalide B | Burkholderia gladioli

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 138439 - 188427:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (orn - ser) + (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg9_156: orn - ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (458..857): orn
  NRPSPredictor2: orn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      orn, lys, arg
    Small clusters prediction:
      orn, horn
    Single AA prediction:
      orn
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DINYWGGIGK
    Nearest Stachelhaus code:
      orn
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1461..1817): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHVSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
ctg9_157: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (1232..1634): X
  NRPSPredictor2: hydrophilic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWdsGLInK
    Nearest Stachelhaus code:
      gln
    Stachelhaus code match:
      70% (weak)