GCF_018916625.1_ASM1891662v1_genomic - 6 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

c00001_NZ_JAHL.. (original name was: NZ_JAHLNC010000001.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	ranthipeptide	662,099	681,369
Region 1.2	ranthipeptide	995,532	1,016,968

c00005_NZ_JAHL.. (original name was: NZ_JAHLNC010000005.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 5.1	RiPP-like	239,146	246,808

c00006_NZ_JAHL.. (original name was: NZ_JAHLNC010000006.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 6.1	cyanobactin	44,573	67,710	locillomycin	NRP + Polyketide	14%

c00014_NZ_JAHL.. (original name was: NZ_JAHLNC010000014.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 14.1	NRPS	1	45,349	equibactin	NRP	14%

c00017_NZ_JAHL.. (original name was: NZ_JAHLNC010000017.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 17.1	cyclic-lactone-autoinducer	1	16,701

Region	Type	From	To	Most similar known cluster	Similarity
Region 1.1	ranthipeptide	662,099	681,369
Region 1.2	ranthipeptide	995,532	1,016,968
Region 5.1	RiPP-like	239,146	246,808
Region 6.1	cyanobactin	44,573	67,710	locillomycin	NRP + Polyketide	14%
Region 14.1	NRPS	1	45,349	equibactin	NRP	14%
Region 17.1	cyclic-lactone-autoinducer	1	16,701

No secondary metabolite regions were found in these records:: c00002_NZ_JAHL.. (original name was: NZ_JAHLNC010000002.1); c00003_NZ_JAHL.. (original name was: NZ_JAHLNC010000003.1); c00004_NZ_JAHL.. (original name was: NZ_JAHLNC010000004.1); c00007_NZ_JAHL.. (original name was: NZ_JAHLNC010000007.1); c00008_NZ_JAHL.. (original name was: NZ_JAHLNC010000008.1); c00009_NZ_JAHL.. (original name was: NZ_JAHLNC010000009.1); c00010_NZ_JAHL.. (original name was: NZ_JAHLNC010000010.1); c00011_NZ_JAHL.. (original name was: NZ_JAHLNC010000011.1); c00012_NZ_JAHL.. (original name was: NZ_JAHLNC010000012.1); c00013_NZ_JAHL.. (original name was: NZ_JAHLNC010000013.1); c00015_NZ_JAHL.. (original name was: NZ_JAHLNC010000015.1); c00016_NZ_JAHL.. (original name was: NZ_JAHLNC010000016.1); c00018_NZ_JAHL.. (original name was: NZ_JAHLNC010000018.1); c00019_NZ_JAHL.. (original name was: NZ_JAHLNC010000019.1); c00020_NZ_JAHL.. (original name was: NZ_JAHLNC010000020.1); c00021_NZ_JAHL.. (original name was: NZ_JAHLNC010000021.1); c00022_NZ_JAHL.. (original name was: NZ_JAHLNC010000022.1); c00023_NZ_JAHL.. (original name was: NZ_JAHLNC010000023.1); c00024_NZ_JAHL.. (original name was: NZ_JAHLNC010000024.1); c00025_NZ_JAHL.. (original name was: NZ_JAHLNC010000025.1); c00026_NZ_JAHL.. (original name was: NZ_JAHLNC010000026.1); c00027_NZ_JAHL.. (original name was: NZ_JAHLNC010000027.1); c00028_NZ_JAHL.. (original name was: NZ_JAHLNC010000028.1); c00029_NZ_JAHL.. (original name was: NZ_JAHLNC010000029.1); c00030_NZ_JAHL.. (original name was: NZ_JAHLNC010000030.1); c00031_NZ_JAHL.. (original name was: NZ_JAHLNC010000031.1); c00032_NZ_JAHL.. (original name was: NZ_JAHLNC010000032.1); c00033_NZ_JAHL.. (original name was: NZ_JAHLNC010000033.1)

Compact view

c00001_NZ_JAHL.. - Region 1 - ranthipeptide

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Location: 662,099 - 681,369 nt. (total: 19,271 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

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core biosynthetic genes

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001387.1	0.17	Other	nucleocidin	Streptomyces calvus
BGC0000599.1	0.17	RiPP	thuricin CD α, thuricin CD β	Bacillus thuringiensis
BGC0000700.1	0.11	Saccharide	istamycin	Streptomyces tenjimariensis
BGC0000604.1	0.09	RiPP	GE2270A	Nonomuraea sp. WU8817
BGC0001860.1	0.09	RiPP	thiomuracin	Thermobispora bispora DSM 43833
BGC0000613.1	0.09	RiPP	thiomuracin A	Nonomuraea sp. Bp3714-39
BGC0001155.1	0.08	RiPP	GE2270	Planobispora rosea
BGC0001591.1	0.07	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.07	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000027.1	0.06	Polyketide	ankaflavin, monascin, rubropunctatine, monascorubrin	Monascus pilosus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001387.1	0.48	Other	nucleocidin	Streptomyces calvus
BGC0000599.1	0.48	RiPP	thuricin CD α, thuricin CD β	Bacillus thuringiensis
BGC0000700.1	0.38	Saccharide	istamycin	Streptomyces tenjimariensis
BGC0000604.1	0.33	RiPP	GE2270A	Nonomuraea sp. WU8817
BGC0001860.1	0.33	RiPP	thiomuracin	Thermobispora bispora DSM 43833
BGC0000613.1	0.33	RiPP	thiomuracin A	Nonomuraea sp. Bp3714-39
BGC0001155.1	0.32	RiPP	GE2270	Planobispora rosea
BGC0001591.1	0.28	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.28	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000027.1	0.26	Polyketide	ankaflavin, monascin, rubropunctatine, monascorubrin	Monascus pilosus

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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c00001_NZ_JAHL.. - Region 2 - ranthipeptide

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Location: 995,532 - 1,016,968 nt. (total: 21,437 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000502.1	0.19	RiPP	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0000504.1	0.19	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.1	0.19	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001407.1	0.18	RiPP	bicereucin	Bacillus cereus SJ1
BGC0000883.1	0.16	Other	arginomycin	Streptomyces arginensis
BGC0000535.1	0.16	RiPP	nisin A	Lactococcus lactis subsp. lactis
BGC0000551.1	0.16	RiPP	SapB	Streptomyces coelicolor A3(2)
BGC0000547.1	0.16	RiPP	salivaricin 9	Streptococcus salivarius
BGC0001526.1	0.16	Other	bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K	Synechocystis salina LEGE 06099
BGC0001525.1	0.16	Other	bartoloside 2, bartoloside 3, bartoloside 4	Synechocystis salina LEGE 06155

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000502.1	0.51	RiPP	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0000504.1	0.51	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.1	0.51	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001407.1	0.50	RiPP	bicereucin	Bacillus cereus SJ1
BGC0000883.1	0.47	Other	arginomycin	Streptomyces arginensis
BGC0000535.1	0.47	RiPP	nisin A	Lactococcus lactis subsp. lactis
BGC0000551.1	0.46	RiPP	SapB	Streptomyces coelicolor A3(2)
BGC0000547.1	0.46	RiPP	salivaricin 9	Streptococcus salivarius
BGC0001526.1	0.46	Other	bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K	Synechocystis salina LEGE 06099
BGC0001525.1	0.46	Other	bartoloside 2, bartoloside 3, bartoloside 4	Synechocystis salina LEGE 06155

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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c00005_NZ_JAHL.. - Region 1 - RiPP-like

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Location: 239,146 - 246,808 nt. (total: 7,663 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

Similar gene clusters

Analysis type:

No matches found.

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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c00006_NZ_JAHL.. - Region 1 - cyanobactin

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Location: 44,573 - 67,710 nt. (total: 23,138 nt) Show pHMM detection rules used

cyanobactin: (cyanobactin_synth or TIGR03678)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001632.1	0.35	RiPP	kawaguchipeptin A	Microcystis aeruginosa NIES-88
BGC0000586.1	0.19	RiPP	microcin E492	Klebsiella pneumoniae RYC492
BGC0000487.1	0.18	RiPP	carnocyclin	Carnobacterium maltaromaticum
BGC0001505.1	0.17	RiPP	anacyclamide D8P	Sphaerospermopsis sp. LEGE 00249
BGC0001933.1	0.17	RiPP	sphaerocyclamide	Sphaerospermopsis sp. LEGE 00249
BGC0000472.1	0.17	RiPP	anacyclamide A10	Anabaena sp. 90
BGC0000479.1	0.17	RiPP	prenylagaramide B, prenylagaramide C	Planktothrix agardhii NIES-596
BGC0001167.1	0.17	RiPP	piricyclamide	Microcystis aeruginosa PCC 7005
BGC0000502.1	0.17	RiPP	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0001222.1	0.17	RiPP	acidocin B	Lactobacillus acidophilus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001632.1	0.68	RiPP	kawaguchipeptin A	Microcystis aeruginosa NIES-88
BGC0000586.1	0.50	RiPP	microcin E492	Klebsiella pneumoniae RYC492
BGC0000487.1	0.49	RiPP	carnocyclin	Carnobacterium maltaromaticum
BGC0001505.1	0.49	RiPP	anacyclamide D8P	Sphaerospermopsis sp. LEGE 00249
BGC0001933.1	0.49	RiPP	sphaerocyclamide	Sphaerospermopsis sp. LEGE 00249
BGC0000472.1	0.49	RiPP	anacyclamide A10	Anabaena sp. 90
BGC0000479.1	0.49	RiPP	prenylagaramide B, prenylagaramide C	Planktothrix agardhii NIES-596
BGC0001167.1	0.48	RiPP	piricyclamide	Microcystis aeruginosa PCC 7005
BGC0000502.1	0.48	RiPP	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0001222.1	0.48	RiPP	acidocin B	Lactobacillus acidophilus

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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c00014_NZ_JAHL.. - Region 1 - NRPS

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Location: 1 - 45,349 nt. (total: 45,349 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000373.1	0.24	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0000412.1	0.24	NRP	pyochelin	Pseudomonas aeruginosa PAO1
BGC0000410.1	0.21	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001636.1	0.21	NRP	KK-1	Curvularia clavata
BGC0001825.1	0.21	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001641.1	0.20	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001615.1	0.20	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001479.1	0.20	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001560.1	0.20	NRP, Polyketide	cryptomaldamide	Moorea producens JHB
BGC0001131.1	0.20	NRP	ambactin	Xenorhabdus miraniensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000373.1	0.57	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0000412.1	0.57	NRP	pyochelin	Pseudomonas aeruginosa PAO1
BGC0000410.1	0.54	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001636.1	0.54	NRP	KK-1	Curvularia clavata
BGC0001825.1	0.54	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001641.1	0.53	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001615.1	0.53	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001479.1	0.53	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001560.1	0.53	NRP, Polyketide	cryptomaldamide	Moorea producens JHB
BGC0001131.1	0.53	NRP	ambactin	Xenorhabdus miraniensis

Similar known gene clusters

Module view

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 45349:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys - Me-cys) + (Me-cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg14_10

Search NORINE for peptide: strict or relaxed

AMP-binding (535..931): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

ctg14_13

Search NORINE for peptide: strict or relaxed

AMP-binding (568..967): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNMSMIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

AMP-binding (1646..2046): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

ctg14_14

Search NORINE for peptide: strict or relaxed

AMP-binding (31..433): dhb

NRPSPredictor2: dhb

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: aLPsQGVICK
Nearest Stachelhaus code:: sal
Stachelhaus code match:: 80% (moderate)

c00017_NZ_JAHL.. - Region 1 - cyclic-lactone-autoinducer

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Location: 1 - 16,701 nt. (total: 16,701 nt) Show pHMM detection rules used

Region on contig edge.

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001586.1	0.14	Saccharide	EPS273	Pseudomonas stutzeri
BGC0001488.1	0.13	Other	4-formylaminooxyvinylglycine	Pseudomonas fluorescens WH6
BGC0001560.1	0.11	NRP, Polyketide	cryptomaldamide	Moorea producens JHB
BGC0001686.1	0.08	NRP	N-octanoyl-Met-Phe-H	Clostridium sp. CAG:567
BGC0000343.1	0.06	NRP	enterobactin	Pseudomonas sp. J465
BGC0000721.1	0.06	Saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0000172.1	0.06	Polyketide	basiliskamide A, basiliskamide B	Brevibacillus laterosporus PE36
BGC0000381.1	0.06	NRP	lichenysin	Bacillus licheniformis DSM 13 = ATCC 14580
BGC0000433.1	0.05	NRP	surfactin	Bacillus velezensis FZB42
BGC0000993.1	0.05	NRP, Polyketide	FR901228	Chromobacterium violaceum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001586.1	0.44	Saccharide	EPS273	Pseudomonas stutzeri
BGC0001488.1	0.41	Other	4-formylaminooxyvinylglycine	Pseudomonas fluorescens WH6
BGC0001560.1	0.38	NRP, Polyketide	cryptomaldamide	Moorea producens JHB
BGC0001686.1	0.30	NRP	N-octanoyl-Met-Phe-H	Clostridium sp. CAG:567
BGC0000343.1	0.26	NRP	enterobactin	Pseudomonas sp. J465
BGC0000721.1	0.25	Saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0000172.1	0.25	Polyketide	basiliskamide A, basiliskamide B	Brevibacillus laterosporus PE36
BGC0000381.1	0.24	NRP	lichenysin	Bacillus licheniformis DSM 13 = ATCC 14580
BGC0000433.1	0.23	NRP	surfactin	Bacillus velezensis FZB42
BGC0000993.1	0.21	NRP, Polyketide	FR901228	Chromobacterium violaceum

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names