GCF_001553625.1_ASM155362v1_genomic - 4 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP014230.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T1PKS	360,558	417,259	myxothiazol	NRP + Polyketide:Modular type I	28%
Region 2	arylpolyene	1,360,988	1,402,532
Region 3	arylpolyene	1,526,510	1,567,700
Region 4	LAP	2,267,718	2,294,871

NZ_CP014230.1 - Region 1 - NRPS,T1PKS

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Location: 360,558 - 417,259 nt. (total: 56,702 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000412.1	0.67	NRP	pyochelin	Pseudomonas aeruginosa PAO1
BGC0000389.1	0.66	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000426.1	0.65	NRP	sevadicin	Paenibacillus larvae
BGC0000373.1	0.61	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0000400.1	0.60	NRP	paenibacterin	Paenibacillus sp. OSY-SE
BGC0000438.1	0.56	NRP	syringopeptin 25A	Pseudomonas syringae pv. syringae
BGC0000351.1	0.56	NRP	exochelin	Mycolicibacterium smegmatis
BGC0001187.1	0.56	NRP, Polyketide	xenolozoyenone	Glarea lozoyensis
BGC0001023.1	0.53	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca
BGC0000632.1	0.51	Terpene, Saccharide	brasilicardin A	Nocardia terpenica

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000412.1	0.66	NRP	pyochelin	Pseudomonas aeruginosa PAO1
BGC0000389.1	0.66	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000426.1	0.66	NRP	sevadicin	Paenibacillus larvae
BGC0000373.1	0.64	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0000400.1	0.64	NRP	paenibacterin	Paenibacillus sp. OSY-SE
BGC0000438.1	0.62	NRP	syringopeptin 25A	Pseudomonas syringae pv. syringae
BGC0000351.1	0.62	NRP	exochelin	Mycolicibacterium smegmatis
BGC0001187.1	0.62	NRP, Polyketide	xenolozoyenone	Glarea lozoyensis
BGC0001023.1	0.60	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca
BGC0000632.1	0.59	Terpene, Saccharide	brasilicardin A	Nocardia terpenica

Similar known gene clusters

Module view

Legend

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 360557 - 417259:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys) + (cys) + (ohmal) + (Me-cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_346

Search NORINE for peptide: strict or relaxed

AMP-binding (518..918): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLwNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 90% (moderate)

ctg1_347

PKS_AT (526..814): mal

ATSignature: Malonyl-CoA, inactive

Top 3 matches:: Malonyl-CoA: 58.3%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 106.9
inactive: 64.3
Methoxymalonyl-CoA: 48.7
Methylmalonyl-CoA: 34.9
Isobutyryl-CoA: 17.3
Propionyl-CoA: 13.5
CHC-CoA: 10.7
Ethylmalonyl-CoA: 10.4
Benzoyl-CoA: 9.5
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg1_348

Search NORINE for peptide: strict or relaxed

AMP-binding (426..828): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

ctg1_349

Search NORINE for peptide: strict or relaxed

AMP-binding (560..958): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNMSMIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

ctg1_350

Search NORINE for peptide: strict or relaxed

AMP-binding (24..431): dhb

NRPSPredictor2: dhb

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: sLPAeGVICK
Nearest Stachelhaus code:: sal
Stachelhaus code match:: 80% (moderate)

ctg1_356

Search NORINE for peptide: strict or relaxed

AMP-binding (53..484): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: cVlYIAcpVK
Nearest Stachelhaus code:: pro
Stachelhaus code match:: 60% (weak)

NZ_CP014230.1 - Region 2 - arylpolyene

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Location: 1,360,988 - 1,402,532 nt. (total: 41,545 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001903.1	0.26	Other	neocarazostatin A	Streptomyces sp. MA37
BGC0000937.1	0.23	Other	fosfazinomycin A	Streptomyces sp. WM6372
BGC0000248.1	0.23	Polyketide	naphtocyclinone	Streptomyces arenae
BGC0000272.1	0.22	Polyketide	spore pigment	Streptomyces collinus
BGC0001739.1	0.22	Other	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0000846.1	0.22	Other	tabtoxin	Pseudomonas syringae
BGC0000228.1	0.21	Polyketide	granaticin	Streptomyces violaceoruber
BGC0000194.1	0.21	Polyketide	actinorhodin	Streptomyces coelicolor A3(2)
BGC0000885.1	0.20	Other	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000219.1	0.20	Polyketide, Saccharide	elloramycin	Streptomyces olivaceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001903.1	0.60	Other	neocarazostatin A	Streptomyces sp. MA37
BGC0000937.1	0.56	Other	fosfazinomycin A	Streptomyces sp. WM6372
BGC0000248.1	0.56	Polyketide	naphtocyclinone	Streptomyces arenae
BGC0000272.1	0.55	Polyketide	spore pigment	Streptomyces collinus
BGC0001739.1	0.55	Other	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0000846.1	0.55	Other	tabtoxin	Pseudomonas syringae
BGC0000228.1	0.54	Polyketide	granaticin	Streptomyces violaceoruber
BGC0000194.1	0.53	Polyketide	actinorhodin	Streptomyces coelicolor A3(2)
BGC0000885.1	0.53	Other	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000219.1	0.52	Polyketide, Saccharide	elloramycin	Streptomyces olivaceus

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NZ_CP014230.1 - Region 3 - arylpolyene

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Location: 1,526,510 - 1,567,700 nt. (total: 41,191 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000836.1	0.24	Other	APE Ec	Escherichia coli CFT073
BGC0000410.1	0.19	NRP	pseudomonine	Pseudomonas fluorescens
BGC0000880.1	0.18	Other (Nucleoside)	tunicamycin B1	Streptomyces chartreusis NRRL 3882
BGC0001964.1	0.18	Polyketide	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0001699.1	0.18	Polyketide	nidulanin A	Aspergillus nidulans FGSC A4
BGC0001588.1	0.18	Saccharide	exopolysaccharides	Burkholderia pseudomallei 1026b
BGC0000204.1	0.17	Polyketide	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0000248.1	0.17	Polyketide	naphtocyclinone	Streptomyces arenae
BGC0001895.1	0.17	Polyketide	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0000234.1	0.17	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000836.1	0.58	Other	APE Ec	Escherichia coli CFT073
BGC0000410.1	0.50	NRP	pseudomonine	Pseudomonas fluorescens
BGC0000880.1	0.50	Other (Nucleoside)	tunicamycin B1	Streptomyces chartreusis NRRL 3882
BGC0001964.1	0.50	Polyketide	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0001699.1	0.49	Polyketide	nidulanin A	Aspergillus nidulans FGSC A4
BGC0001588.1	0.49	Saccharide	exopolysaccharides	Burkholderia pseudomallei 1026b
BGC0000204.1	0.49	Polyketide	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0000248.1	0.49	Polyketide	naphtocyclinone	Streptomyces arenae
BGC0001895.1	0.49	Polyketide	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0000234.1	0.49	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_CP014230.1 - Region 4 - LAP

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Location: 2,267,718 - 2,294,871 nt. (total: 27,154 nt) Show pHMM detection rules used

LAP: ((((goadsporin_like or PF00881 or TIGR03605) and (YcaO or TIGR03882 or TIGR03604)) or TIGR03603 or TIGR03602) and not cyanobactin_synth)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001174.1	0.26	RiPP	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0000569.1	0.24	RiPP	plantazolicin	Bacillus velezensis FZB42
BGC0001173.1	0.23	RiPP	plantazolicin	Bacillus pumilus ATCC 7061
BGC0001170.1	0.21	RiPP	clostridiolysin S	Clostridium sporogenes ATCC 15579
BGC0000564.1	0.21	RiPP	clostridiolysin S	Clostridium botulinum A str. ATCC 3502
BGC0000451.1	0.18	NRP	turnerbactin	Teredinibacter turnerae T7901
BGC0000475.1	0.18	RiPP	patellamide A, patellamide C	Prochloron didemni
BGC0001588.1	0.17	Saccharide	exopolysaccharides	Burkholderia pseudomallei 1026b
BGC0000565.1	0.16	RiPP	goadsporin	Streptomyces sp. TP-A0584
BGC0002013.1	0.16	RiPP	curacozole	Streptomyces curacoi

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001174.1	0.59	RiPP	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0000569.1	0.57	RiPP	plantazolicin	Bacillus velezensis FZB42
BGC0001173.1	0.56	RiPP	plantazolicin	Bacillus pumilus ATCC 7061
BGC0001170.1	0.54	RiPP	clostridiolysin S	Clostridium sporogenes ATCC 15579
BGC0000564.1	0.54	RiPP	clostridiolysin S	Clostridium botulinum A str. ATCC 3502
BGC0000451.1	0.50	NRP	turnerbactin	Teredinibacter turnerae T7901
BGC0000475.1	0.49	RiPP	patellamide A, patellamide C	Prochloron didemni
BGC0001588.1	0.48	Saccharide	exopolysaccharides	Burkholderia pseudomallei 1026b
BGC0000565.1	0.47	RiPP	goadsporin	Streptomyces sp. TP-A0584
BGC0002013.1	0.46	RiPP	curacozole	Streptomyces curacoi

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names