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Overview
1.1
1.2
1.3
1.4

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP014230.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | NRPS,T1PKS | 360,558 | 417,259 | myxothiazol | NRP + Polyketide:Modular type I | 28%
Region 2 | arylpolyene | 1,360,988 | 1,402,532 |
Region 3 | arylpolyene | 1,526,510 | 1,567,700 |
Region 4 | LAP | 2,267,718 | 2,294,871 |

NZ_CP014230.1 - Region 1 - NRPS,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 360,558 - 417,259 nt. (total: 56,702 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000412.1 |  |  | 0.67 | NRP | pyochelin | Pseudomonas aeruginosa PAO1
BGC0000389.1 |  |  | 0.66 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000426.1 |  |  | 0.65 | NRP | sevadicin | Paenibacillus larvae
BGC0000373.1 |  |  | 0.61 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064
BGC0000400.1 |  |  | 0.60 | NRP | paenibacterin | Paenibacillus sp. OSY-SE
BGC0000438.1 |  |  | 0.56 | NRP | syringopeptin 25A | Pseudomonas syringae pv. syringae
BGC0000351.1 |  |  | 0.56 | NRP | exochelin | Mycolicibacterium smegmatis
BGC0001187.1 |  |  | 0.56 | NRP, Polyketide | xenolozoyenone | Glarea lozoyensis
BGC0001023.1 |  |  | 0.53 | NRP, Polyketide | myxochromide S1 | Stigmatella aurantiaca
BGC0000632.1 |  |  | 0.51 | Terpene, Saccharide | brasilicardin A | Nocardia terpenica

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000412.1 |  | 0.66 | NRP | pyochelin | Pseudomonas aeruginosa PAO1
BGC0000389.1 |  | 0.66 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000426.1 |  | 0.66 | NRP | sevadicin | Paenibacillus larvae
BGC0000373.1 |  | 0.64 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064
BGC0000400.1 |  | 0.64 | NRP | paenibacterin | Paenibacillus sp. OSY-SE
BGC0000438.1 |  | 0.62 | NRP | syringopeptin 25A | Pseudomonas syringae pv. syringae
BGC0000351.1 |  | 0.62 | NRP | exochelin | Mycolicibacterium smegmatis
BGC0001187.1 |  | 0.62 | NRP, Polyketide | xenolozoyenone | Glarea lozoyensis
BGC0001023.1 |  | 0.60 | NRP, Polyketide | myxochromide S1 | Stigmatella aurantiaca
BGC0000632.1 |  | 0.59 | Terpene, Saccharide | brasilicardin A | Nocardia terpenica

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 360557 - 417259:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (cys) + (cys) + (ohmal) + (Me-cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_346: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (518..918): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLwNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      90% (moderate)
ctg1_347: mal
  PKS_AT (526..814): mal
  ATSignature: Malonyl-CoA, inactive
  Top 3 matches:
    Malonyl-CoA: 58.3%
    inactive: 58.3%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 106.9
    inactive: 64.3
    Methoxymalonyl-CoA: 48.7
    Methylmalonyl-CoA: 34.9
    Isobutyryl-CoA: 17.3
    Propionyl-CoA: 13.5
    CHC-CoA: 10.7
    Ethylmalonyl-CoA: 10.4
    Benzoyl-CoA: 9.5
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg1_348: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (426..828): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)
ctg1_349: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (560..958): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNMSMIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)
ctg1_350: dhb
  Search NORINE for peptide: strict or relaxed
  AMP-binding (24..431): dhb
  NRPSPredictor2: dhb
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      dhb, sal
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      sLPAeGVICK
    Nearest Stachelhaus code:
      sal
    Stachelhaus code match:
      80% (moderate)
ctg1_356: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (53..484): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      cVlYIAcpVK
    Nearest Stachelhaus code:
      pro
    Stachelhaus code match:
      60% (weak)

NZ_CP014230.1 - Region 2 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,360,988 - 1,402,532 nt. (total: 41,545 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001903.1 |  | 0.26 | Other | neocarazostatin A | Streptomyces sp. MA37
BGC0000937.1 |  | 0.23 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0000248.1 |  | 0.23 | Polyketide | naphtocyclinone | Streptomyces arenae
BGC0000272.1 |  | 0.22 | Polyketide | spore pigment | Streptomyces collinus
BGC0001739.1 |  | 0.22 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0000846.1 |  | 0.22 | Other | tabtoxin | Pseudomonas syringae
BGC0000228.1 |  | 0.21 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0000194.1 |  | 0.21 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)
BGC0000885.1 |  | 0.20 | Other | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000219.1 |  | 0.20 | Polyketide, Saccharide | elloramycin | Streptomyces olivaceus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001903.1 |  | 0.60 | Other | neocarazostatin A | Streptomyces sp. MA37
BGC0000937.1 |  | 0.56 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0000248.1 |  | 0.56 | Polyketide | naphtocyclinone | Streptomyces arenae
BGC0000272.1 |  | 0.55 | Polyketide | spore pigment | Streptomyces collinus
BGC0001739.1 |  | 0.55 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0000846.1 |  | 0.55 | Other | tabtoxin | Pseudomonas syringae
BGC0000228.1 |  | 0.54 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0000194.1 |  | 0.53 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)
BGC0000885.1 |  | 0.53 | Other | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000219.1 |  | 0.52 | Polyketide, Saccharide | elloramycin | Streptomyces olivaceus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP014230.1 - Region 3 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,526,510 - 1,567,700 nt. (total: 41,191 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000836.1 |  | 0.24 | Other | APE Ec | Escherichia coli CFT073
BGC0000410.1 |  | 0.19 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0000880.1 |  | 0.18 | Other (Nucleoside) | tunicamycin B1 | Streptomyces chartreusis NRRL 3882
BGC0001964.1 |  | 0.18 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0001699.1 |  | 0.18 | Polyketide | nidulanin A | Aspergillus nidulans FGSC A4
BGC0001588.1 |  | 0.18 | Saccharide | exopolysaccharides | Burkholderia pseudomallei 1026b
BGC0000204.1 |  | 0.17 | Polyketide | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0000248.1 |  | 0.17 | Polyketide | naphtocyclinone | Streptomyces arenae
BGC0001895.1 |  | 0.17 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0000234.1 |  | 0.17 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000836.1 |  | 0.58 | Other | APE Ec | Escherichia coli CFT073
BGC0000410.1 |  | 0.50 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0000880.1 |  | 0.50 | Other (Nucleoside) | tunicamycin B1 | Streptomyces chartreusis NRRL 3882
BGC0001964.1 |  | 0.50 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0001699.1 |  | 0.49 | Polyketide | nidulanin A | Aspergillus nidulans FGSC A4
BGC0001588.1 |  | 0.49 | Saccharide | exopolysaccharides | Burkholderia pseudomallei 1026b
BGC0000204.1 |  | 0.49 | Polyketide | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0000248.1 |  | 0.49 | Polyketide | naphtocyclinone | Streptomyces arenae
BGC0001895.1 |  | 0.49 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0000234.1 |  | 0.49 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP014230.1 - Region 4 - LAP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,267,718 - 2,294,871 nt. (total: 27,154 nt) Show pHMM detection rules used
LAP: ((((goadsporin_like or PF00881 or TIGR03605) and (YcaO or TIGR03882 or TIGR03604)) or TIGR03603 or TIGR03602) and not cyanobactin_synth)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | LAP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001174.1 |  | 0.26 | RiPP | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0000569.1 |  | 0.24 | RiPP | plantazolicin | Bacillus velezensis FZB42
BGC0001173.1 |  | 0.23 | RiPP | plantazolicin | Bacillus pumilus ATCC 7061
BGC0001170.1 |  | 0.21 | RiPP | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0000564.1 |  | 0.21 | RiPP | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0000451.1 |  | 0.18 | NRP | turnerbactin | Teredinibacter turnerae T7901
BGC0000475.1 |  | 0.18 | RiPP | patellamide A, patellamide C | Prochloron didemni
BGC0001588.1 |  | 0.17 | Saccharide | exopolysaccharides | Burkholderia pseudomallei 1026b
BGC0000565.1 |  | 0.16 | RiPP | goadsporin | Streptomyces sp. TP-A0584
BGC0002013.1 |  | 0.16 | RiPP | curacozole | Streptomyces curacoi

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001174.1 |  | 0.59 | RiPP | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0000569.1 |  | 0.57 | RiPP | plantazolicin | Bacillus velezensis FZB42
BGC0001173.1 |  | 0.56 | RiPP | plantazolicin | Bacillus pumilus ATCC 7061
BGC0001170.1 |  | 0.54 | RiPP | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0000564.1 |  | 0.54 | RiPP | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0000451.1 |  | 0.50 | NRP | turnerbactin | Teredinibacter turnerae T7901
BGC0000475.1 |  | 0.49 | RiPP | patellamide A, patellamide C | Prochloron didemni
BGC0001588.1 |  | 0.48 | Saccharide | exopolysaccharides | Burkholderia pseudomallei 1026b
BGC0000565.1 |  | 0.47 | RiPP | goadsporin | Streptomyces sp. TP-A0584
BGC0002013.1 |  | 0.46 | RiPP | curacozole | Streptomyces curacoi

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names