GCF_000013425.1_ASM1342v1_genomic - 6 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NC_007795.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	siderophore	77,516	93,234	staphylobactin	Other	87%
Region 2	NRPS	129,045	176,220	aureusimine	NRP	100%
Region 3	lanthipeptide-class-i	1,843,450	1,867,680	hyicin 3682	RiPP	100%
Region 4	cyclic-lactone-autoinducer	2,083,820	2,104,580
Region 5	siderophore	2,253,966	2,268,981	staphyloferrin A	Other:Non-NRP siderophore	100%
Region 6	T3PKS,terpene	2,611,568	2,663,150

NC_007795.1 - Region 1 - siderophore

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Location: 77,516 - 93,234 nt. (total: 15,719 nt) Show pHMM detection rules used

siderophore: IucA_IucC

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000943.1	0.89	Other	staphylobactin	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000295.1	0.30	NRP	acinetoferrin	Acinetobacter haemolyticus
BGC0001453.1	0.30	Other	desferrioxamine	Streptomyces argillaceus
BGC0001870.1	0.30	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0000939.1	0.29	Other	aerobactin	Grimontia hollisae
BGC0000946.1	0.25	Other	vibrioferrin	Vibrio parahaemolyticus
BGC0000942.1	0.23	Other	petrobactin	Bacillus anthracis str. Ames
BGC0001184.1	0.21	Other	bacilysin	Bacillus velezensis FZB42
BGC0000888.1	0.21	Other	bacilysin	Bacillus sp. CS93
BGC0001408.1	0.18	Other	xanthoferrin	Xanthomonas oryzae pv. oryzae KACC 10331

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000943.1	0.96	Other	staphylobactin	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000295.1	0.64	NRP	acinetoferrin	Acinetobacter haemolyticus
BGC0001453.1	0.64	Other	desferrioxamine	Streptomyces argillaceus
BGC0001870.1	0.63	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0000939.1	0.62	Other	aerobactin	Grimontia hollisae
BGC0000946.1	0.59	Other	vibrioferrin	Vibrio parahaemolyticus
BGC0000942.1	0.56	Other	petrobactin	Bacillus anthracis str. Ames
BGC0001184.1	0.54	Other	bacilysin	Bacillus velezensis FZB42
BGC0000888.1	0.54	Other	bacilysin	Bacillus sp. CS93
BGC0001408.1	0.49	Other	xanthoferrin	Xanthomonas oryzae pv. oryzae KACC 10331

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Detailed TIGRFAM domain annotation

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NC_007795.1 - Region 2 - NRPS

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Location: 129,045 - 176,220 nt. (total: 47,176 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

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NRPS/PKS domains

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NRPS/PKS modules

Pfam domains

TIGRFAM domains

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000308.1	0.88	NRP	aureusimine	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001479.1	0.27	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000852.1	0.24	Other	ectoine	Sporosarcina pasteurii
BGC0000853.1	0.23	Other	ectoine	Streptomyces anulatus
BGC0001128.1	0.23	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.1	0.23	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000859.1	0.23	Other	ectoine	Methylomicrobium alcaliphilum
BGC0001135.1	0.23	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000855.1	0.23	Other	ectoine	Methylomicrobium kenyense
BGC0000856.1	0.23	Other	ectoine	Methylophaga thalassica

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000308.1	0.96	NRP	aureusimine	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001479.1	0.61	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000852.1	0.57	Other	ectoine	Sporosarcina pasteurii
BGC0000853.1	0.57	Other	ectoine	Streptomyces anulatus
BGC0001128.1	0.57	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.1	0.57	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000859.1	0.57	Other	ectoine	Methylomicrobium alcaliphilum
BGC0001135.1	0.56	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000855.1	0.56	Other	ectoine	Methylomicrobium kenyense
BGC0000856.1	0.56	Other	ectoine	Methylophaga thalassica

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 2, location 129044 - 176220:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (val - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_125

Search NORINE for peptide: strict or relaxed

AMP-binding (417..807): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAfWLGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 90% (moderate)

AMP-binding (1442..1834): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAmSIGaViK
Nearest Stachelhaus code:: lys
Stachelhaus code match:: 70% (weak)

NC_007795.1 - Region 3 - lanthipeptide-class-i

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Location: 1,843,450 - 1,867,680 nt. (total: 24,231 nt) Show pHMM detection rules used

lanthipeptide-class-i: ((LANC_like and (Lant_dehydr_N or Lant_dehydr_C)) and not (YcaO or TIGR03882))

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MIBiG comparison

KnownClusterBlast

Lanthipeptides

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001618.1	0.54	RiPP	hyicin 3682	Staphylococcus hyicus
BGC0000541.1	0.31	RiPP	paenicidin A	Paenibacillus polymyxa
BGC0000542.1	0.31	RiPP	paenicidin B	Paenibacillus terrae
BGC0000508.1	0.29	RiPP	epidermin	Staphylococcus epidermidis
BGC0000538.1	0.29	RiPP	nisin Z	Lactococcus lactis
BGC0000556.1	0.29	RiPP	streptin	Streptococcus pyogenes
BGC0000543.1	0.28	RiPP	pep5	Staphylococcus epidermidis
BGC0000544.1	0.26	RiPP	planosporicin	Planomonospora alba
BGC0001407.1	0.24	RiPP	bicereucin	Bacillus cereus SJ1
BGC0001727.1	0.24	RiPP	paenilan	Paenibacillus polymyxa E681

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001618.1	0.81	RiPP	hyicin 3682	Staphylococcus hyicus
BGC0000541.1	0.64	RiPP	paenicidin A	Paenibacillus polymyxa
BGC0000542.1	0.64	RiPP	paenicidin B	Paenibacillus terrae
BGC0000508.1	0.63	RiPP	epidermin	Staphylococcus epidermidis
BGC0000538.1	0.62	RiPP	nisin Z	Lactococcus lactis
BGC0000556.1	0.62	RiPP	streptin	Streptococcus pyogenes
BGC0000543.1	0.62	RiPP	pep5	Staphylococcus epidermidis
BGC0000544.1	0.59	RiPP	planosporicin	Planomonospora alba
BGC0001407.1	0.57	RiPP	bicereucin	Bacillus cereus SJ1
BGC0001727.1	0.57	RiPP	paenilan	Paenibacillus polymyxa E681

Similar known gene clusters

Lanthipeptide predictions

Lanthipeptide(s) for ctg1_1692 - Putative Class I

ctg1_1693 leader / core peptide: MEKVLDLDVQVKANNNSNDSAGDE - RIDhbDhaHDhaLCDhbPGCAKDhbGDhaFNDhaFCC
allorf_1858625_1858768 leader / core peptide: LEKVLDLDVQVKGNNNTNDSAGDE - RIDhbDhaHLFCDhaFGCEKDhbGDhaFNDhaFCC

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Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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Lanthipeptides

Core peptide predictions

ctg1_1693 - Class I

Cleavage pHMM score: 3.40

RODEO score: 33

Monoisotopic mass: 2247.1 Da

Molecular weight: 2248.6 Da

Number of bridges: 3

Additional modifications: AviCys

Alternative weights: (assuming N unmodified Ser/Thr residues); 2266.6 Da N = 1; 2284.7 Da N = 2; 2302.7 Da N = 3

allorf_1858625_1858768 - Class I

Cleavage pHMM score: 0.40

RODEO score: 26

Monoisotopic mass: 2419.1 Da

Molecular weight: 2420.8 Da

Number of bridges: 3

Additional modifications: AviCys

Alternative weights: (assuming N unmodified Ser/Thr residues); 2438.8 Da N = 1; 2456.9 Da N = 2

NC_007795.1 - Region 4 - cyclic-lactone-autoinducer

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Location: 2,083,820 - 2,104,580 nt. (total: 20,761 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

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core biosynthetic genes

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001687.1	0.13	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSL12
BGC0000207.1	0.13	Polyketide	chartreusin	Streptomyces chartreusis
BGC0001872.1	0.08	Polyketide	fabclavine-polyamine	Xenorhabdus bovienii SS-2004
BGC0001053.1	0.08	NRP, Polyketide	tubulysin A	Archangium disciforme
BGC0001130.1	0.07	NRP, Polyketide	fabclavine Ia	Xenorhabdus budapestensis
BGC0001700.1	0.05	Polyketide	niphimycins C-E	Streptomyces sp. IMB7-145
BGC0000082.1	0.04	Polyketide	kijanimicin	Actinomadura kijaniata
BGC0000163.1	0.03	Polyketide	tetronasin	Streptomyces longisporoflavus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001687.1	0.42	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSL12
BGC0000207.1	0.41	Polyketide	chartreusin	Streptomyces chartreusis
BGC0001872.1	0.32	Polyketide	fabclavine-polyamine	Xenorhabdus bovienii SS-2004
BGC0001053.1	0.30	NRP, Polyketide	tubulysin A	Archangium disciforme
BGC0001130.1	0.27	NRP, Polyketide	fabclavine Ia	Xenorhabdus budapestensis
BGC0001700.1	0.21	Polyketide	niphimycins C-E	Streptomyces sp. IMB7-145
BGC0000082.1	0.20	Polyketide	kijanimicin	Actinomadura kijaniata
BGC0000163.1	0.17	Polyketide	tetronasin	Streptomyces longisporoflavus

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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NC_007795.1 - Region 5 - siderophore

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Location: 2,253,966 - 2,268,981 nt. (total: 15,016 nt) Show pHMM detection rules used

siderophore: IucA_IucC

Legend:

core biosynthetic genes

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MIBiG comparison

KnownClusterBlast

Pfam domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000944.1	1.00	Other (Non-NRP siderophore)	staphyloferrin A	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001870.1	0.21	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0000939.1	0.20	Other	aerobactin	Grimontia hollisae
BGC0000947.1	0.18	Other	vibrioferrin	Vibrio alginolyticus
BGC0000883.1	0.16	Other	arginomycin	Streptomyces arginensis
BGC0000943.1	0.14	Other	staphylobactin	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000703.1	0.14	Saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001211.1	0.08	NRP	albachelin	Amycolatopsis alba DSM 44262
BGC0000423.1	0.08	NRP	scabichelin	Streptomyces scabiei 87.22
BGC0001767.1	0.08	NRP	salinichelins	Salinispora pacifica CNY331

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000944.1	1.00	Other (Non-NRP siderophore)	staphyloferrin A	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001870.1	0.53	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0000939.1	0.53	Other	aerobactin	Grimontia hollisae
BGC0000947.1	0.49	Other	vibrioferrin	Vibrio alginolyticus
BGC0000883.1	0.47	Other	arginomycin	Streptomyces arginensis
BGC0000943.1	0.44	Other	staphylobactin	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000703.1	0.43	Saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001211.1	0.32	NRP	albachelin	Amycolatopsis alba DSM 44262
BGC0000423.1	0.31	NRP	scabichelin	Streptomyces scabiei 87.22
BGC0001767.1	0.31	NRP	salinichelins	Salinispora pacifica CNY331

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NC_007795.1 - Region 6 - T3PKS,terpene

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Location: 2,611,568 - 2,663,150 nt. (total: 51,583 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

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core biosynthetic genes

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000647.1	0.47	Terpene	carotenoid	Rhodobacter sphaeroides
BGC0000644.1	0.41	Terpene	carotenoid	Dietzia sp. CQ4
BGC0000648.1	0.39	Terpene	carotenoid	Myxococcus xanthus
BGC0000645.1	0.39	Terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000637.1	0.39	Terpene	carotenoid	Corynebacterium glutamicum
BGC0000787.1	0.37	Saccharide	O-antigen	Escherichia coli
BGC0001412.1	0.35	Saccharide	polysaccharide C	Bacteroides fragilis
BGC0000636.1	0.34	Terpene	carotenoid	Brevibacterium linens
BGC0000646.1	0.34	Terpene	β-carotein	uncultured bacterium
BGC0000640.1	0.33	Terpene	carotenoid	Enterobacteriaceae bacterium DC404

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000647.1	0.65	Terpene	carotenoid	Rhodobacter sphaeroides
BGC0000644.1	0.59	Terpene	carotenoid	Dietzia sp. CQ4
BGC0000643.1	0.58	Terpene	carotenoid	Brevundimonas vesicularis
BGC0000634.1	0.58	Terpene	carotenoid	Brevundimonas sp. SD212
BGC0000640.1	0.57	Terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000656.1	0.57	Terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000646.1	0.57	Terpene	β-carotein	uncultured bacterium
BGC0000648.1	0.57	Terpene	carotenoid	Myxococcus xanthus
BGC0000637.1	0.56	Terpene	carotenoid	Corynebacterium glutamicum
BGC0000630.1	0.56	Terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis

Similar known gene clusters

No matches found.

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Detailed TIGRFAM domain annotation

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