LOCUS       c00107_NZ_JAJB..       13642 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_JAJBNW010000046.1 Anaerosalibacter bizertensis strain MSK.14.19
            PBLBGLII_46, whole genome shotgun sequence.
ACCESSION   c00107_NZ_JAJB..
VERSION     c00107_NZ_JAJB..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 01:45:24
            Original ID  :: NZ_JAJBNW010000046.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2734
            Orig. end    :: 16376
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13642
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[12734:14694]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..11960
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..13642
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13642
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             318..1802
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg107_3"
                     /sec_met_domain="PALP (E-value: 2.2e-18, bitscore: 56.7,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYISTRNKTIPISSSEAIIQGISKDGGLFVPINIPKIENIGALK
                     EADYKELAFIIMSKFFTDFELSILKNCINNAYDNKFSEKEIVPLLKVGDVFFLELFHGP
                     TLAFKDMALSILPHLLKEAININKIDREVVILTATSGDTGKAALEGFANVGGIKIIVFF
                     PEDGVSKIQKKQMLTQEGSNTFVVGIDGNFDDAQNGVKGIFNDQNFVRFLDKNKYILSS
                     ANSINIGRLIPQIVYYFYGYLTLLREGKIEDNEKINIVVPTGNFGNILAAYYAKEMGLP
                     INKLICASNENNVLTDFIKTGIYDKRRELILTSSPSMDILISSNLERLLFHISGGDSIF
                     VKNKMDELVKDGYYKIDKSNLKDFYGSYSTEEGISSSINKVFAENNYIMDPHTAVAYNV
                     YEKYKEETCDNTKTIIVSTASPFKFGTKVASSIGIDIKNKDEFNIIEALATKTDIEIPK
                     AISNLKDKEVIHNNKCNKEDMKGLIEKFLEVGDIDD"
     CDS             1795..2691
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GHMP_kinases_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GHMP_kinases_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg107_4"
                     /sec_met_domain="GHMP_kinases_C (E-value: 4.9e-11,
                     bitscore: 33.1, seeds: 112, tool: rule-based-clusters)"
                     /sec_met_domain="GHMP_kinases_N (E-value: 3.6e-13,
                     bitscore: 39.8, seeds: 447, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKVKVPATSANIGPGFDTLGIALQLYNTFFFEEIDEGLEINGCD
                     NDYANENNLVYTSMLETFKKIGYEAKGIKITLNTNIPIARGLGSSAACILGGVIGANEI
                     AKASLSKGEILEIATEIEGHPDNIAPALFGGLVVSVTEDENIYYNKINIANGIKFVVLI
                     PDFTLSTSEAREVLPSTVNYKDAIYNVGRVSLLLSALSNGRFDLLKASLMDRLHQPYRK
                     KLIPKGDEIINKSYELGALGTYISGAGPTIMAIIKDNNMNFTVSIKNYLNFINCNWTVK
                     ELDLNLSGVGIEKGIKE"
     CDS             2762..3562
                     /locus_tag="ctg107_5"
                     /transl_table=11
                     /translation="MVIDGGVYMWTRKELKSEAKKFLKRNYWKAFIVCLITALLSGGIS
                     NSSTNSSIDNENGEPFFQQEYHNIKISPSMDLLSSLDKGLENPFVFKVTSKAFILLIII
                     GLILRIVVGNVLEVGQKRFFIDGFKGCPEIGKLFTTFKNGEWLPITGKMLLMNIYLLLW
                     TLLLVIPGIIKGYEYRMVPYILSENPYISLSDAIQISKEMTNDEKWEIFILDLSFLGWL
                     LLGSLLFGIGGIFVLPYKEATIAKLYEHYRENIPLEEQFNYILD"
     CDS             3752..3898
                     /locus_tag="ctg107_6"
                     /transl_table=11
                     /translation="MDNNSLSHMKWNCKYHIVFAPKYRRQIIYGKIKQDVGRILVNYVN
                     IKE"
     CDS             3937..4047
                     /locus_tag="ctg107_7"
                     /transl_table=11
                     /translation="MLVSIPPKLSVSSFMGYLKGKSSLMIFDRHANLKYK"
     CDS             4424..5092
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) B12-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg107_8"
                     /sec_met_domain="B12-binding (E-value: 2.3e-25, bitscore:
                     79.1, seeds: 91, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHVKEKLLNDLAESVVDMEEDDAVQVANDFIESGYDAYEGISNG
                     LAVGMDEAGKLYEEEEYYIPELLMCSDAMYAGMDVLKPYLKYDETEEKYKAVVGVVEGD
                     THDIGKNLFKIMLETTGFEVYDLGRDVPPSEFINKAKELGAKLIGLSTLMTTTMDNMEI
                     VINLLKEEGIRDDVVVMVGGGPISQSFADKIGADGYAPEASRAARLAKDLVRGKMNVAV
                     "
     CDS             5079..6170
                     /locus_tag="ctg107_9"
                     /transl_table=11
                     /translation="MSLFKDEMTPMERAIALSKGEDVDRIQCNPNLSNGIARVLGCKIS
                     EFNHSARTLADAVIATHRRFGGDGAKVFTDLFIIAEAMGAKMKYPEDETVDLLEPAIKD
                     ISEISKLEPIDPYKDARLPIHIEAMKYVQDEIGEEVPCTALVVGPFTSAFFLIGVETMT
                     KMMIKDPESVHKLCEISLENCMRFADATIKQGIGISIAEPMSSCTVVSPKHFREFSKPY
                     LKRFVDFIKSKGSGTSIHICGKTDGIWEDVVDIGVGALSIDNIASLKDCTETVGDRIKI
                     MGNVDPSSIMYAGTKEDVRKATLQCVKDGYKSPKGYGIMSGCGLPVETPIENIDAMLDT
                     AREIGWPITDEKLEELMSFNRYE"
     CDS             6197..7255
                     /locus_tag="ctg107_10"
                     /transl_table=11
                     /translation="MPINSLSKKERLFRAIKREKVDRPPCICPGGMMNMIIEDIMDITE
                     VEWPEAHKDPKMMAKLTMGVCENGGFENFGVPFCMTVEAESMGAVVGLGTKINEPRVIE
                     YPINSVTEWKKLKELDLTKGRTKVVLDAIEILKSESSGIPIIANLVGPVSTASSLMEPV
                     DYYKELRRKPKEAHEFMEFVTENLIGFAKAQIQAGADILAISDPSGTGEILGPKLFKEF
                     AAPYLNKIVNSVKEDAPGGTIIHICGKLKSVYGILNSLDSDAISFDSIASVREVANNVN
                     NKAIMGNVSTLALEKSSPDIIKNLAKGCIKSGVDILSPACGIGPRTKLENIQSMVEVAK
                     ESTSENIVLKSS"
     CDS             7272..9083
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RACo_C_ter"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg107_11"
                     /sec_met_domain="Fer2 (E-value: 7.1e-11, bitscore: 32.1,
                     seeds: 206, tool: rule-based-clusters)"
                     /sec_met_domain="RACo_C_ter (E-value: 5.6e-77, bitscore:
                     248.3, seeds: 142, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNMLEIYNKDISYSYEEGKSLLDILQDSGEIIESPCGGKGYCGKC
                     KVQIIKGKLEKPTEEELKYLSKKDLEKNIRLGCFVYPKGYTCVKFLNKEEKNYKALSDG
                     YIPDIELNPIIYKEVITWEKPTLKNNFSYEETLEKSIGEELYHNDTEILKALANVDNEE
                     KVTLLYYEDKLIGIESGDTKDELYGAAVDIGTTTVVVSLIDLNTGKEIGTETSINPQKE
                     YGLDVLSRIDFVKRKDNGLYLLQKAIVECINFLLENLCNKNGIDIQNVYEIAVGANATM
                     MHLLLGIGTNTIGKSPYATIFSKEKNLWAKSIGLKISSFGRLYCLPGVSSFIGADIVAG
                     AVVANLKDTKDNVFFIDIGTNGEMLLSKGGKLVSCSCAAGPALEGANISCGMRAAEGAI
                     EGIQFNEDGVELQVIGDVEPIGICGSGILEAIAELHKKEIIKKSGRLKRKEDLEKEERH
                     ILAEHLMEEGKKRKVILYKNGDEMISITQEDIRQVQLAKGAISSGFYALLDFMDMGMED
                     LDSIVIAGQFGRHLKTGSLTGVGIIPENLKDKINYIGNSSKTGAMICLLSKYARKEMED
                     IAKDIEYFELSTKEGYEKLFTKCLTFN"
     CDS             9101..9976
                     /locus_tag="ctg107_12"
                     /transl_table=11
                     /translation="MSEIMDFKCISDKMEEIPEDIVKKTGLSFPEVHTKAEYIATLSKE
                     LKEYKKDNLCRVPFCNTVETEALGGNIKLGDAKAGPRVESYAFNSIDELMEIEEIDLNR
                     KRINEVLKAVEILNSQGETVVLNVEGPFTIITSLVDSRIFYKAIRKNKEMIYEILNVIE
                     DSVIKYMQEGINRGANIISYGDPVGSLDIVGPRVYKEFSGRVTYNILKRMESELDNSIM
                     HICGKTSTAFQNMGYIKSHPIRFENKITYGQAIDHILENKKDIKIIGHNCIKRTALELK
                     NSTIWSIEFL"
     CDS             10001..11167
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg107_13"
                     /sec_met_domain="HGD-D (E-value: 1.2e-90, bitscore: 294.6,
                     seeds: 370, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGEITMNNLPKAFDDFSEARRNSFIKVKDYKDEGEHIVGIFCTF
                     TPIEVIYAAGAHPISLCGMSDETIPDAERDLPKNLCPLIKSSYGFALTDKCPFTYFSDI
                     IVGETTCDGKKKMYEYLNQIKPMHVMQLPQATDREHALSVWKNEIIILKERLEKEFNVK
                     ITDDDLKKAIKKCNEERRALKELYSLSKICPPPITGMELHTVLHGASFTFDKDEQNKKI
                     MDMVEQLKEEHANGVRKVEEDAPRILITGCPMGGVADKLVPIIESNGAVVVCYENCSGI
                     KEKSRLVDETKDPVEAIAEKYLNVGCSVMAPNDNRIELMSELIDEYKVDGVIDVILQAC
                     HTYNVETRRIKEFVTGEKDIPYMSIETDYSQADEGQLKTRVAAFIEML"
     CDS             11202..11960
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg107_14"
                     /sec_met_domain="BcrAD_BadFG (E-value: 3e-55, bitscore:
                     177.6, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYYAGVDIGSTAAKTALFENDKLIDAFVVPTGWSSIETANTIKEK
                     IVSKGIKEEEMKVVATGYGRVSVPYAHKTITEITCHGKGAAYLTGEDCTVVDIGGQDTK
                     VITVENGMIVDFLMNDKCSAGTGRFLEIMANTLGVDIDTLCDLAETGSGISISSMCTVF
                     AESEVISLIGRGEKKEDIAYAIVDSIISKVASLCNKHSKGTNYYLTGGLCECDYIVRSL
                     SEKLKSPVKTNPMARYAGAIGAGVLAQKIK"
     CDS             complement(12067..13140)
                     /locus_tag="ctg107_15"
                     /transl_table=11
                     /translation="MGLRFRKSVKIAPGVRVNFNKKSTSVSFGSKGVRHTISSTGRRTS
                     SVGIPGSGLYYTKSSSAKKSRNRKNNTYTTNNEYTYEDPYYEVEQFNSFIETITSFHKN
                     CDYSMDWDKIRKEPPPFNLEKKGPNEIEALESLNNYKPNLIEKIFKNVNKKKIDKLKNN
                     VELSKTKDMELYRNWEKQNIQAQSILEGNLTTYTNILNDMDFLNNLSEFVPKFDFQFSN
                     KDEMIIEYNLNIDNVVPEKYATLTKTGKLSIRKYTKTDYYEVVQQYVSSLAIRIARNIF
                     GLLPIKTVIINTKNNILDTSIGEIKNITILSVKIDRNTLNGLNFDLINPFDAMSNFEHN
                     VRFLKTKGFQPVEKINI"
     CDS             13313..13642
                     /locus_tag="ctg107_16"
                     /transl_table=11
                     /translation="MSKLFDIHPLVVDKDIATTLGLNEAIILQQVHYWIEINKKHKRNC
                     HKGRYWTYNTIEEWQEEFPFWSTSTVKRIFKRLRDRKIIIVDNFNTYQMDRTLWYTIDY
                     EELEKI"
ORIGIN
        1 gtagaagata cctatagaaa aggcaatcca ctaggggaaa ggaagcttaa caacctaaat
       61 gaaaaattaa aagctgaata ttatttaaga atttctttac ctgaagaaca agagggaaaa
      121 gtttttaaag ctattaaaaa tatttctaaa aaactgttat ctgaaaaaga aaatattgca
      181 attataacta atgaaattga gtatttagaa ataattaaat tgttatcatc cttagaaatt
      241 gataaaaata attattttat tgctagaatt attaagtaaa attttatttt aagtatggtg
      301 aagggaagga tattaatatg gaatatataa gtactaggaa caaaacaata cctatttcat
      361 caagtgaagc aataatacaa ggaatttcaa aagatggagg gctatttgtt ccaatcaata
      421 tacctaaaat tgagaatatt ggagctttga aagaagcaga ttataaagaa ctagctttta
      481 taataatgag caaatttttt acagatttcg aattaagtat acttaaaaat tgcattaata
      541 atgcttatga taataaattt agtgaaaaag agattgtacc cttattaaag gttggagatg
      601 tattttttct tgaacttttc catggtccaa ctttagcatt taaagatatg gcattatcta
      661 tacttccaca tttattaaag gaagctataa atataaataa aatagatagg gaagtagtta
      721 tactgactgc tacttctgga gatacaggca aagcagcgtt agaggggttt gccaatgttg
      781 gtggaattaa aataatagta ttttttcctg aagacggtgt aagtaaaata cagaagaaac
      841 aaatgcttac tcaagaagga agcaacacct ttgtagtagg tattgatgga aattttgatg
      901 atgctcaaaa tggagtaaag gggattttta atgatcagaa ttttgtaaga tttttagata
      961 aaaataaata tatattatcc tctgccaatt caatcaatat aggtaggcta attcctcaaa
     1021 ttgtttacta tttctatgga tatctgaccc ttctaaggga aggaaaaata gaagataatg
     1081 aaaagataaa tattgtagtt cccacaggta attttggaaa tatcttagca gcatattatg
     1141 caaaggaaat gggacttcct ataaataagt taatatgtgc ttctaatgaa aacaatgttt
     1201 taaccgattt tatcaaaact ggaatatatg ataagagaag ggagcttatt ttaacttcat
     1261 ctccatctat ggatattcta atatctagta atttagaaag acttttattc catataagtg
     1321 ggggagacag tatatttgtt aagaataaaa tggatgagct tgttaaggat ggctattata
     1381 aaatagataa atcaaatttg aaagattttt atggttctta ttcaactgaa gaagggataa
     1441 gttcttcaat caacaaggta tttgcagaaa ataactacat aatggatcct catactgcag
     1501 tagcttataa tgtctatgaa aaatacaagg aagagacttg tgataataca aaaactataa
     1561 ttgtatcaac tgctagtcca ttcaaatttg gaacaaaagt agcatcgtct attggtatag
     1621 atataaaaaa taaagatgaa ttcaatataa tagaagcatt agcaactaag acagatattg
     1681 aaatacctaa agccatatca aatcttaagg ataaagaggt tatacataat aacaaatgta
     1741 ataaagaaga catgaaaggt ttaattgaaa aatttttaga agtaggtgat atagatgatt
     1801 aaagttaaag tacctgccac aagtgcaaac ataggaccgg gatttgatac cttaggcatt
     1861 gccctccagc tctataatac atttttcttt gaagaaatag atgaaggttt agaaattaat
     1921 ggctgtgata atgattatgc caatgaaaat aatttagtat atacttcaat gttagaaact
     1981 tttaaaaaaa taggatatga agctaagggt ataaaaataa ctttaaatac taatatacct
     2041 atagctagag gactaggaag tagtgcagca tgtattttag gaggggttat aggtgctaat
     2101 gagatagcta aagcttcttt atcaaaaggg gaaattctag aaatagctac agaaatagaa
     2161 ggccatccag acaatattgc tcctgcacta tttggaggcc ttgtagtctc tgttacagag
     2221 gatgaaaata tatactataa taagattaat atagctaatg ggattaaatt tgtagtattg
     2281 attcctgatt ttaccctatc aacatctgag gctagagaag ttttaccttc aaccgttaat
     2341 tataaagatg ctatatataa tgtaggaagg gtgtctttat tactctctgc tttgtccaat
     2401 ggtagatttg atttattgaa agcttcatta atggatagac tacatcagcc ctataggaaa
     2461 aaactaatac ctaaaggtga tgaaattata aacaaatctt atgaactagg tgctttaggt
     2521 acatatataa gtggtgcagg ccctactata atggctatta ttaaagataa taatatgaat
     2581 tttacagtaa gtattaaaaa ttatctcaat tttattaatt gtaactggac tgttaaagaa
     2641 ttagacttaa acttatctgg ggtgggtata gagaagggta taaaagagta gttaattatg
     2701 ttacaattgg aagtgaatat attctattat ttaacataaa ttgaagtata tttataatat
     2761 aatggttatt gatgggggtg tatacatgtg gactagaaaa gagctaaaat ctgaggccaa
     2821 gaaatttttg aaaaggaact attggaaagc atttatagta tgtttaatta cagcccttct
     2881 ttcaggaggt attagtaata gttcaacaaa tagcagcata gataatgaaa atggagaacc
     2941 tttttttcag caagaatacc ataatattaa aataagtcca agtatggatc tgctaagttc
     3001 tttagataaa ggtttagaaa acccttttgt atttaaagta acttcaaaag cttttattct
     3061 cttgataatc attggactaa tacttaggat agtagttgga aatgtattgg aagtaggaca
     3121 aaagcgattt tttattgatg gatttaaagg atgtccagag attggcaaat tatttaccac
     3181 ctttaaaaat ggagagtggt tgcctattac aggaaaaatg cttcttatga atatttatct
     3241 cttgttatgg acactgttac ttgttatacc tggtatcata aagggttatg aatataggat
     3301 ggttccatat attttatctg aaaatccata tataagtcta tcagatgcca tacaaattag
     3361 taaagaaatg accaatgatg agaaatggga aatatttatt ttagatcttt cttttttagg
     3421 ttggcttctt ttaggctcat tactttttgg cattggaggt atatttgtac ttccatacaa
     3481 ggaagcaact attgccaagc tatatgaaca ctacagagaa aacattcctt tagaagaaca
     3541 gtttaactat attttagatt aaaaatacat atataatatt ttaaaataag gctgtttcaa
     3601 aatttaattt tgaaacagcc ttattatatt atgaatacca cctgctaagc gggtggttga
     3661 aaaaagcttc tagcgttaag cagaaaaaac ctctagtgat atgataagtt taggtctagc
     3721 caaccaaact taagtcaaag gaggtatcca tatggataat aatagtttat cacatatgaa
     3781 atggaattgt aaatatcaca tagtttttgc accaaaatat aggagacaaa taatatatgg
     3841 aaagataaag caagatgttg gaaggatact agtcaattat gtgaatataa aggagtagaa
     3901 ttaatagaag cagagacctg caaagaccat attcatatgc tagttagtat accacctaaa
     3961 ttaagtgtat caagttttat gggatattta aaaggtaaaa gtagtttaat gatatttgat
     4021 agacatgcaa atttaaaata taaataaaga atatatagat cctttcacag gaaaaaagac
     4081 aaataagtaa ggataataat taaatccctt aagggatagt gtgagaaggt acagcggttg
     4141 gcaggccttt ttcggggtgt cttgagatac agtaaataac atgcccttac agggctaaag
     4201 caaaccaccc gttttatagg tggctatgat ttagtaaaac agatgtaaat ctatggttaa
     4261 aaataattaa atctttagta tatataataa caatagttga aagccttatc attgaaaaat
     4321 ctaataatat tggaaatttt ttttatttac atatagtata ttaattggaa taagaaagat
     4381 cttaaaatca gttaaagtaa aactagagtg gaggttgata ctgatgtccc atgtaaaaga
     4441 aaagctttta aatgatttgg cggaatctgt agtggatatg gaagaagatg atgctgttca
     4501 agtcgcaaac gatttcatag aaagtggata tgatgcatat gaaggaattt ctaatggctt
     4561 agctgttgga atggatgaag caggcaagct ttacgaagaa gaagagtact atattccaga
     4621 acttctaatg tgttcagatg ccatgtatgc aggtatggac gttttgaaac cctatttaaa
     4681 atatgatgaa actgaagaaa aatataaagc agtagttggg gtagtagagg gagataccca
     4741 tgatatagga aagaatctat ttaaaatcat gttagaaact acagggtttg aagtatatga
     4801 tttgggaaga gatgtgccac ctagtgaatt tattaacaaa gcaaaggaat tgggagctaa
     4861 attaattggt ctttcaactt taatgacaac tactatggac aatatggaaa tagttattaa
     4921 tttattgaaa gaagaaggta taagggatga tgtagtagtt atggttggag gaggtccaat
     4981 atcacagagt tttgcagata aaataggtgc agatggatat gcaccagaag cttcaagggc
     5041 tgcaagatta gctaaagatt tagtaagggg gaagatgaat gtcgctgttt aaagatgaaa
     5101 tgacacctat ggaaagggct atcgctcttt caaaaggaga agatgtagat agaattcagt
     5161 gcaatcctaa tctatctaat ggtattgcaa gggttttagg atgcaagatt tcagagttta
     5221 accacagtgc tagaacttta gctgatgcag ttattgcaac tcatagaagg tttggtggag
     5281 atggtgcaaa ggtatttaca gatcttttta taattgcgga ggctatgggt gctaagatga
     5341 aatatccaga ggatgaaaca gtagaccttt tagaaccagc cataaaggat atttcagaaa
     5401 tatctaaatt agaacctata gatccataca aggatgcaag attgccaatc catattgaag
     5461 ccatgaaata tgtacaagat gaaataggag aagaagttcc ttgtacagcc ttagttgttg
     5521 gacccttcac ttctgctttc tttttaattg gtgtagaaac tatgacaaag atgatgataa
     5581 aagatcctga atcggttcat aaattatgtg aaatttcatt agaaaactgc atgagatttg
     5641 cggatgccac tattaaacag ggaataggca taagtattgc agaacctatg tcctcttgta
     5701 ctgtagtgag tccaaaacac tttagagaat tttcaaagcc atatttaaaa agatttgtag
     5761 attttattaa gtctaaaggc tctggaactt cgatacatat atgtggaaaa acagatggca
     5821 tatgggaaga tgtagtagat ataggcgtag gagctttaag tatagataat attgcaagcc
     5881 ttaaagattg cacggaaact gtaggagata ggataaagat aatgggaaat gtagaccctt
     5941 cttctataat gtatgcaggt actaaggagg atgttaggaa ggctacgcta cagtgtgtaa
     6001 aagatggata taagtctcct aaaggatatg gcattatgtc aggctgtgga cttccagtag
     6061 aaacacctat agaaaatatt gatgccatgc tggatacagc tagggaaata ggatggccaa
     6121 ttacagatga aaaactagaa gagttaatga gctttaatag atatgaataa tatgaattga
     6181 tttaaggggg atttttatgc ctataaattc tttatctaaa aaagaaagac tatttcgtgc
     6241 aataaaaagg gaaaaagtag atcggcctcc atgtatctgt cctggtggta tgatgaatat
     6301 gattatagaa gatattatgg atattactga agtagagtgg ccagaagcac acaaggatcc
     6361 aaagatgatg gcaaagctta ctatgggagt ttgtgaaaat ggaggttttg aaaatttcgg
     6421 agtacctttt tgtatgactg tagaagcaga atctatgggt gctgttgtag gtttaggtac
     6481 taagataaat gagcctaggg ttatagaata tccaataaat tctgttacag agtggaaaaa
     6541 gcttaaagag ttagacttaa ccaaagggag aactaaagta gttttagatg ctatagagat
     6601 acttaaaagt gaaagttcag gtattcctat tatagctaat ttagtgggac ctgtaagtac
     6661 agcgtcttct ttgatggaac cagtagatta ttataaggag cttagaagaa aacctaaaga
     6721 agctcatgaa tttatggaat ttgttacgga aaatcttata ggttttgcta aggctcagat
     6781 acaagctgga gcagatatat tagctatttc agatcctagt ggtacgggag aaattttagg
     6841 cccaaagcta tttaaagaat ttgccgctcc ttatttaaac aaaatagtca attcagttaa
     6901 agaggatgct ccaggaggga ctataatcca tatatgtggg aagctaaaaa gtgtatatgg
     6961 aatacttaat tcccttgaca gtgatgctat aagttttgat tctatagcta gtgtgagaga
     7021 agtagcaaat aatgtaaaca acaaagctat tatgggaaat gtaagtacct tagcccttga
     7081 aaaaagctct ccagatatta taaaaaatct tgctaaaggt tgtataaaaa gtggggtgga
     7141 tatattatct ccagcctgtg gtataggtcc aagaactaaa ttagaaaata tacagtcaat
     7201 ggtagaggtt gcaaaagaat caacatcaga aaatatagta ttaaaatcat catagatgga
     7261 gtgaagaatt tatgaatatg ttggaaatat acaacaaaga tatatcctat agctatgaag
     7321 aagggaaaag ccttcttgat atattgcaag atagtggaga aattatagaa agtccttgtg
     7381 gtggaaaagg ctattgtgga aaatgtaagg ttcaaataat taaagggaag ctagagaagc
     7441 ctacagaaga ggaactaaaa tatctttcaa agaaagacct agaaaaaaat ataaggcttg
     7501 gttgctttgt ctatcctaag ggttatacat gtgtaaaatt tttaaataaa gaagaaaaaa
     7561 attataaggc attatcagat ggctatattc ctgatataga actaaatcct attatttata
     7621 aagaagttat tacctgggaa aagcctactt tgaaaaataa tttctcttac gaggagactt
     7681 tagaaaaatc tataggtgag gaactatatc ataatgatac tgaaatttta aaggctttgg
     7741 ccaatgtaga taatgaagaa aaagttactt tactatatta tgaagataaa ttaataggta
     7801 tagaatctgg agacacaaaa gatgaattat atggggctgc agtggatatt ggaactacta
     7861 cagtagttgt atcccttata gatttaaata ctggtaaaga gattggaaca gaaacttcta
     7921 taaatcctca gaaagaatat ggccttgatg tactatctcg tatagatttt gtaaaaagaa
     7981 aggataatgg tctctattta ttgcagaagg ctatagtaga gtgtataaac ttcctattag
     8041 aaaatctatg taataaaaat ggtatagata ttcaaaatgt ctatgaaata gctgtaggag
     8101 ctaatgctac tatgatgcat ctactattgg ggattggaac caacactata ggcaaatcac
     8161 catatgctac aattttttca aaagaaaaaa acttatgggc caagagtata ggccttaaaa
     8221 tatcatcatt tggaagacta tattgcttgc caggagtatc tagtttcatt ggtgcagata
     8281 tcgtagctgg agctgtagta gctaatttaa aagatactaa agacaatgta ttttttattg
     8341 atattggaac aaatggggaa atgctattgt ctaaaggtgg aaagcttgtc tcgtgttcct
     8401 gtgctgctgg tccagcacta gaaggggcaa atataagttg tggcatgaga gcggcagaag
     8461 gagctattga aggcatacaa tttaacgaag atggagttga acttcaagta attggagatg
     8521 tagaacctat aggaatatgt ggaagcggca tattagaagc catagctgag ctccataaaa
     8581 aagagattat aaagaagtct ggcagattga aaagaaaaga ggatttagaa aaagaagaac
     8641 gtcatatatt agctgaacat ctaatggaag aaggcaagaa aaggaaagtt attttatata
     8701 aaaatggaga tgaaatgata tctataaccc aagaagatat tagacaagtc caattagcta
     8761 aaggtgctat ttcctctgga ttctatgcac ttttagattt tatggatatg ggtatggaag
     8821 atcttgacag tatagttata gcaggacagt ttggcagaca tttaaagaca ggtagtttga
     8881 ctggtgtagg gattatacca gaaaatttga aggacaagat aaattatata ggaaactcat
     8941 ctaaaactgg agctatgata tgtttattat ctaagtatgc aagaaaggaa atggaggaca
     9001 tagctaagga tatagaatac tttgagctat ctacaaaaga aggttatgaa aagttattta
     9061 ctaaatgttt aacttttaat taatatagac aggtgataaa atgagtgaaa tcatggactt
     9121 taagtgtata agtgacaaaa tggaagaaat ccctgaggat atagtgaaaa aaacaggatt
     9181 aagctttcca gaagttcata ctaaagctga atatatagca actctgtcga aagaactaaa
     9241 ggagtataaa aaagataact tatgcagagt tcctttttgc aatactgtag aaacagaagc
     9301 attaggagga aatattaaac taggagatgc taaagcaggt cctagggtgg aaagttatgc
     9361 ttttaattct atagatgaat tgatggaaat tgaagaaata gacttaaaca ggaaaagaat
     9421 aaatgaagtt ttaaaagctg tagaaatatt gaattcacaa ggagaaactg tagttctaaa
     9481 tgtagaaggg ccttttacca ttataacctc tctagtagat tcaaggatat tttataaagc
     9541 tataagaaaa aacaaggaaa tgatttatga aattttaaat gttatagaag acagtgttat
     9601 aaagtatatg caggaaggaa taaatagagg agcaaatata atatcttatg gagatcctgt
     9661 aggctcttta gatattgtag ggccaagagt atataaggag tttagtggaa gggttactta
     9721 taatatatta aaacgtatgg aaagtgaatt agataatagc ataatgcata tttgtggaaa
     9781 gacatctaca gcttttcaaa atatgggata tattaaatct catcctatta gatttgaaaa
     9841 taagataacc tatggtcaag ctatagatca tattttggaa aataagaaag atataaaaat
     9901 aataggccac aattgtatca aaagaacagc tttagaactt aaaaattcaa ctatttggtc
     9961 tatagagttt ttatagaaat agaataataa atttactttt atgaaagggg aaataacgat
    10021 gaataactta ccaaaagcat ttgatgattt tagtgaggca agaagaaatt cctttataaa
    10081 ggttaaagat tataaagatg aaggagaaca tatagtaggt attttttgta ctttcacccc
    10141 tatagaggtt atatatgcag caggagctca tccaatttca ttatgtggta tgagtgatga
    10201 aacaatacca gatgctgaaa gggatcttcc taagaattta tgtcctctta taaaatcaag
    10261 ttatggtttt gccttaacag ataaatgtcc ctttacatac ttttcagata taattgtagg
    10321 agaaacaact tgtgatggaa agaaaaagat gtatgaatat ttaaatcaaa taaaaccaat
    10381 gcatgttatg caacttcctc aagctacaga tagagaacat gcactttcgg tttggaaaaa
    10441 tgagattatt atattgaaag aaagactaga aaaagaattt aatgttaaga taacagatga
    10501 tgatttgaaa aaagctataa aaaaatgtaa tgaagaaaga agagcactga aagaattgta
    10561 ttctctaagt aaaatatgtc ctcctcctat aactggaatg gaacttcaca ccgtactaca
    10621 tggtgcgtcc tttacttttg ataaagatga gcaaaacaaa aagataatgg atatggtaga
    10681 acagttaaaa gaagaacatg caaatggagt tagaaaggta gaagaagatg ctccaagaat
    10741 tttaataaca ggttgtccaa tgggaggagt tgcagataaa cttgtaccta ttatagagtc
    10801 aaatggagca gtagttgtat gttatgaaaa ctgtagtgga ataaaggaaa aatcacgttt
    10861 agtagatgaa actaaggatc cagttgaggc aatagctgaa aaatatttaa atgttggatg
    10921 ttcagttatg gcaccaaatg ataatagaat tgaactaatg tctgagctaa tagatgaata
    10981 caaagttgat ggtgtaatag atgttatttt acaagcttgc catacctata atgtagagac
    11041 tcgtaggatt aaagaatttg taactggaga aaaagatata ccatatatga gtatagaaac
    11101 agactattca caagcagatg aaggacaatt gaagactaga gtagcagctt ttatagagat
    11161 gttataatta ttttgtattt gttttgagga gggataggaa tatgtattat gctggggttg
    11221 atattggatc tacagcagct aaaacagctt tatttgaaaa tgataaacta atagatgctt
    11281 ttgttgtgcc tacaggctgg agcagtattg aaacagccaa tacaataaaa gaaaaaattg
    11341 tatctaaagg aataaaagaa gaagaaatga aagtagtagc tacaggttat ggaagggttt
    11401 ctgtccctta tgctcacaaa actattacgg aaataacttg ccatggaaaa ggggctgcat
    11461 atcttacagg ggaagattgt actgtagtag atataggcgg acaggataca aaagttataa
    11521 ctgtagaaaa cggtatgata gtggattttt taatgaatga taaatgttct gcaggtacag
    11581 gtagattttt agagattatg gcaaatactt taggtgtaga tatagacact ctttgcgatt
    11641 tagctgaaac tggtagcggt atctctataa gttccatgtg tacagttttt gcagaatcag
    11701 aagtaataag ccttattggt agaggagaga aaaaagaaga tatagcctat gctatagttg
    11761 attcaataat aagcaaagta gctagtctgt gtaataagca ttcaaaaggt acaaactatt
    11821 atctcacagg tggactatgt gaatgtgact atatagttag aagtttatca gaaaaactta
    11881 aaagtccagt aaaaacaaat cctatggcaa gatatgctgg agccatagga gcaggggttt
    11941 tagcacaaaa gataaaatag atgtggaaaa tgggaaagtt atatataaag aataattaac
    12001 aaaaaagctt taacatagat atccatgtta aagctttttt agtacattaa tattataata
    12061 aataatttat atatttattt tttcaacagg ttgaaatcct ttggttttaa gaaatctaac
    12121 attatgttca aaattactca tagcatcaaa aggattgatt aaatcaaaat ttaacccatt
    12181 taatgtattt ctatctattt taacagaaag tatagttata ttttttattt ctcctatcga
    12241 agtatccaat atattatttt ttgtatttat tataacagtt tttataggca atagaccaaa
    12301 tatatttctt gctattctta tggccaaact ggatacatat tgttgaacaa cttcataata
    12361 atcagttttt gtatattttc taatagagag ttttcctgtt ttagtcagtg tagcatactt
    12421 ttcaggtaca acattatcta tattcaaatt gtactctatt atcatctcat ctttattaga
    12481 aaattggaaa tcaaactttg gtacaaattc acttaagtta tttaaaaaat ccatatcatt
    12541 taaaatattc gtataggtgg ttaagtttcc ttccaaaata gattgagcct gtatattctg
    12601 tttttcccaa tttctataaa gttccatatc ctttgtttta gataattcta cgttattttt
    12661 taatttgtct attttctttt tattcacatt tttaaatatt ttttctatta agttaggttt
    12721 ataattattt agagattcta aagcttctat ttcatttgga cctttctttt ctaaattaaa
    12781 agggggaggt tctttacgta ttttgtccca gtccatactg tagtcacaat ttttatggaa
    12841 agaggttatt gtttcaataa aggaattaaa ttgttcaact tcataataag gatcttcata
    12901 ggtatattca ttatttgtgg tatatgtatt attttttcta tttctagatt ttttagcaga
    12961 gctacttttt gtataatata gtcctgatcc aggtataccc acacttgaag ttcttctccc
    13021 tgttgagctt atagtatgtc taactccttt gctaccgaag cttacactag tacttttttt
    13081 attaaaattg actcttacac caggagcgat ttttacactt tttctaaatc ttaatcccat
    13141 aaaaacatca cctcatataa taaattatac catatttata atttatatct attatctata
    13201 ctaaaaatag tatagcaaat aataaattta gaaataaaaa tttaaaaaac aatagtaaga
    13261 ttcctcctgt ttttctatat aagaagtaga tagaaaaata ggagggattt ttatgtctaa
    13321 attattcgat atacatccat tagtagtgga taaagatata gcaactacat taggcctaaa
    13381 tgaagcaata atacttcaac aagtacatta ttggatagag ataaataaaa agcataaaag
    13441 gaattgtcat aaaggtagat attggaccta caatactata gaagaatggc aggaagaatt
    13501 tccattctgg agtacctcaa cagtgaaaag aatatttaaa agattgagag acagaaaaat
    13561 aattattgtg gataacttca acacatacca aatggataga accctttggt atacaattga
    13621 ctatgaagaa ttagaaaaaa ta
//
