LOCUS       c00014_NZ_LEKH..       14491 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_LEKH01000022.1 Rubrobacter aplysinae strain RV113
            contig22_size45326, whole genome shotgun sequence.
ACCESSION   NZ_LEKH01000022
VERSION     NZ_LEKH01000022
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-13 23:51:07
            Original ID  :: NZ_LEKH01000022.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 30835
            Orig. end    :: 45326
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14491
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[40835:41873](+)"
                     /cutoff="20000"
                     /detection_rule="((Fe-ADH or Fe-ADH_2) and Dak1 and Dak2)"
                     /neighbourhood="10000"
                     /product="Oxidative_glycerol"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..11038
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="20000"
                     /detection_rule="((Fe-ADH or Fe-ADH_2) and Dak1 and Dak2)"
                     /neighbourhood="10000"
                     /product="Oxidative_glycerol"
                     /protocluster_number="1"
     cand_cluster    1..14491
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((Fe-ADH or Fe-ADH_2) and Dak1 and Dak2)"
                     /kind="single"
                     /product="Oxidative_glycerol"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14491
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Oxidative_glycerol"
                     /region_number="1"
                     /rules="((Fe-ADH or Fe-ADH_2) and Dak1 and Dak2)"
                     /tool="gutsmash"
     CDS             23..1390
                     /locus_tag="ctg14_35"
                     /transl_table=11
                     /translation="MQDRHGAREDTGNVEDMLRDSRRRTLELVGDLDEEQMMGPQLKIV
                     NPPLWEIGHLAWFQEYWNLRRRDGTRDEFSGSEFLERPDEIYNSAEIDHDSRWGADLLS
                     TSGTHDYMQNVLDRTLDRLDREGGPELSYYSRLATFHEDMHAEAFTYTRHTHGLPAPEL
                     SDYDPHALDGQPTGPLPGDAEIPGGEFMLGADPGSVERGEVPFVFDNEKWAHPVQVAPF
                     KMARGQVTYGQFAEFVESGGYEKPGLWSEAGWRWREENGIERPLYWEKRGTGDGEWHRR
                     HFDRLEPIPENAAVIHVGYHEAEAYCNWAGRRLPTEAEWELAAAAEPAPDGGISSRKRL
                     YPWGDKPPVPGDRRANLDGILMGTVDVAAFPEGESAFGVRQMLGNVWEWCSDVFQPYPG
                     YERDPYKEYSEPWFGDHMVLRGGCWATRSRMLRNTWRNFYMPDRRDTFVGFRTCAR"
     CDS             complement(1397..2248)
                     /locus_tag="ctg14_36"
                     /transl_table=11
                     /translation="MPSAAGLTSRWMAAARARESARADRLFDDPLAADFAGPEGFAWLR
                     TMDLAATTLGAGPGLFSVVRTRFYDEFLARAVRQSGARQIVLLAAGMDARAFRLEWPAG
                     TRLYELDLPEVLELKEELLTHKKPPGNCKRRPVGVDLSGGGWPRALNEAGHDPEEPSVW
                     LAEGFFLYLRRAEVHALLDRVGTLSAPGSRLGADFINRDFLFSPVAWPLLESFSRLGSP
                     LRFGTNDPESLLAGHGWRARAVQPGEPGASYGRWPYPVPPRGLPGLPRSFLLTARRETG
                     DA"
     misc_feature    complement(1883..1885)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="gutsmash"
     CDS             complement(2324..4210)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 277.9; E-value:
                     4e-85)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg14_37"
                     /sec_met_domain="AMP-binding (E-value: 3.1e-85, bitscore:
                     277.9, seeds: 145, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding_C (E-value: 2.9e-26, bitscore:
                     84.0, seeds: 272, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIAEYREFHRRSVEEPEAFWAEKARLIDWQKEWDEVLDFSSPPF
                     ARWFVGGETNLCYNMVDRHLSERSDQAALVYVSTETGERETYTYRELYDEVNAFAAALR
                     GLGVGRGDRVVIYMPMMAEALFAMLACVRLGAIHSVVFGGFAAPNLASRIDDARPKALV
                     TADAGSRGGNVIPYKPLVDEALETAEHPPPSVVIRNRGLDPDMNVVEGRDLDYATLRKE
                     HWGAEVPVEWVESSEPSYILYTSGTTGTPKGIQRDTGGYAVALAASMRDVFDSEPGETM
                     FTASDIGWVVGHSYIVYAPLLHGMTTVVYEGLPTRPDPGVWWSIVEEYGVNTMFTSPTA
                     IRALRKQDPEYMQRHDTSSLRKLYLAGEPLDEPTSRWAAESLGVSIRDNYWQTETGWPI
                     LSSMLPGLEDGPLKPGSAGFACAGYDLRLLEEGTGEEVGPDERGVLTIVPPLPPGCMST
                     IWGDDQRFVETYFRDFPQEVYSTFDWGTRDEEGHYFILGRSDDVINVAGHRLGTREIEE
                     AISDHPDVAEAAAVGVKDEYKGQVVLAYVVAGDPESAGPELEQSVKDIVDKQVGAIARP
                     ASVHFVEALPKTRSGKMLRRGIQALAESRDPGDLSTLEDPSALESVRASSEG"
     CDS             4317..4640
                     /locus_tag="ctg14_38"
                     /transl_table=11
                     /translation="VREWLYKKDEKGGPRRFLSHRELAAWDALKVGRFAGPPLGLCVVA
                     TIFDPQELGRLAFLSLGLMLLAFCVAVVAVMYLYVALSGGVMGPEERLRYRERLRESRR
                     GRW"
     misc_feature    4509..4511
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="gutsmash"
     CDS             complement(4644..5507)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 55.1; E-value: 2.6e-17)"
                     /gene_kind="transport"
                     /locus_tag="ctg14_39"
                     /sec_met_domain="BPD_transp_1 (E-value: 2.1e-17, bitscore:
                     55.1, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASPRTERRPSVSKTPQIGGALPRVSWKTSLAVLVILGLTGWSGL
                     GVGFDLLDLLSGAQPVQSFVSEMFPPDLSASTLQTTFTGVVETFQMAFLGALIGAVVAF
                     PLAALGTREASTVGASRARRLALAVPYHAARLLTNVFRSVPDILWALVFVVALGLGPFP
                     GMLALAVHSAGVLGKLYSETLEAVPERPVEALHETGASGFGAFIFGRMPQAMASVTSLS
                     LYQWECNLRSATILGFVGAGGIGQEILVSMQLFDYPKVATLVGATIIVVLIVDRFSAAL
                     RSRLVN"
     CDS             complement(5488..6381)
                     /locus_tag="ctg14_40"
                     /transl_table=11
                     /translation="LNEAPGNSSRVSKSSRDSLGFELDDATVSYGGAPALKHVSLSVKP
                     GERLAVIGASGAGKSTLFRLLTRGVALGSGRVTIGGDDLFGLSWRELKELRSRVGVVRQ
                     AYNLVPQLPVGVNAGLGEVGSIGGWRALKMLAAGPDAGLASRVREALERLGLLELARSR
                     TSDISGGQQQRVAVARLLVQRPGLVLADEPFAAVDPQTTERVLEAVAELNGEGSTLVVN
                     LHDVELARRFPRIVALREGRLFYDGGPEGLTDERLAGVYSGDPYHPSPHPEAPDGTGPR
                     GVSPRVTGGQDGVTSH"
     CDS             complement(6389..7264)
                     /locus_tag="ctg14_41"
                     /transl_table=11
                     /translation="LRGRRNVRRAGVIALGAISLALVGCGSSQDEEALSVGLIPNQNPE
                     EVQAQYQPLEEYLSGELDRPVELEVPTSYNAVVEAMTSGELDLAYFGGLTYAQARERAD
                     ISPLVTEINPRTGDTKYRSAIIAPANGEVEEVEDIEGKDFAFGSASSTSGSLYPSIMLD
                     EAGVDYRTDLGEYTYTGGHDATAQAVANERVAAGGLEYRILLDLVEQGTIDEDSYRVIQ
                     TILVEGYPWVVRDDLPENLREEVAQAYLDLEDPELLDLLRAQGYERVEPGDYDEVEEQA
                     RELDLLTPTE"
     CDS             7677..8045
                     /locus_tag="ctg14_42"
                     /transl_table=11
                     /translation="VSEAYKEPVESVEEGAGDHASVVVLGGDAFELLERLQGWRRPPVY
                     ANVDLTSGISSEAPGLRFLSWHVESVTPTRRRIIELARKVSSLLAPGVSCVSTSDRGLC
                     GFCRYCGYRGYEYYESRG"
     CDS             8420..9946
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg14_43"
                     /sec_met_domain="FGGY_C (E-value: 3e-64, bitscore: 208.0,
                     seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="FGGY_N (E-value: 5.3e-81, bitscore: 263.4,
                     seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGTHILAIDQGTTGTTVLVFNHDGEVVGRSYSEFTQHYPKPGWV
                     EHDANEIWSVTLRCIGTALGDANISASKELEAIGITNQRETAVMWDRSTGEPVHHAIVW
                     QDRRGAELCDSLNDQGYGPMVREKTGLNIDAYFSGSKVKWLLDNVDGLRERAERGEICF
                     GTIDSWLVYKLTGGREHVTDYTNASRTLLYNIFDLQWDDDLLGMLEVPREILPEVKPSS
                     HVYGNTDPEAFFRAEIPVAGIAGDQQAALFGEACYERGMAKNTYGTGSFALMNTGTEPI
                     KSEGELLTTISWGIGDEPVEYALEGAIFITGAAVQWLRDGLGIIKDASETEELARSVDD
                     NGGVYYVPALVGLGAPHWDPYARGTIIGLTRGTTKAHLARAALESMAYQTRDAVDAMER
                     DSGIKLPSFRADGGAAANSWMMQFQADILGVPVEVPDITETTALGAAYLAGIATGFWKS
                     RQDVADKWRLSSRYEPQMSDDDREWLYGRWTGAVERSKGWAREAVESPLT"
     CDS             10001..11038
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Oxidative_glycerol: Dak1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_44"
                     /sec_met_domain="Dak1 (E-value: 7.3e-128, bitscore: 417.4,
                     seeds: 351, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVLNAPDRAVEEMLRGMELAHGGRNGNDGESGLIRRLSGQTVA
                     VRADAPVSGKVAIVSGGGSGHEPAHAGYVGPGMLDAACAGEVFTSPSPEPVLEATKAVD
                     GGAGVFYVVKNYTGDVLNFEMAGELAGTEDIETDYVVINDDVAVEDSTHTTGRRGVAGT
                     VLVHKICGGAADDGKSLPEIKSLAARVNENVRSMGMALTSCVPPERGEPIFDIAEDEME
                     LGIGIHGEPGTERRKIEPADSIVDMLLEKVLGDSVDYSGSGGQDVAVMVNGMGGTPLME
                     LYVAYARVHDVLAENGINVHGAPYVGEYMTSLEMAGFSVTLLKLDDEMKRYLAAPCSVA
                     AGGLF"
     CDS             11107..11862
                     /locus_tag="ctg14_45"
                     /transl_table=11
                     /translation="VDFSVYLAEFVGTLILVLLGDGVVAGVLLRYSKAEDAGWIVITFG
                     WGLAVALAVYSVGWVSGAHINPAVTVGLASIGSFDWAMVPGYILAQMLGAFTGAVLVWL
                     AYYDHWGATEDAGLKLGAFCTAPGIRNTVPNFITEVIGTAMLVFGVVAIGANATAIGSS
                     GGVDLAAVFSTGIAPLLVGFLVLAIGLSLGGPTGYAINPARDLGPRIAHAVLPIAGKGG
                     SDWGYSWIPVVAPIVGGVIGAVAYNILGF"
     CDS             11974..12600
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dak2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg14_46"
                     /sec_met_domain="Dak2 (E-value: 4.5e-57, bitscore: 184.4,
                     seeds: 138, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LGATESTVAAVRAMAAAMKENREHLTQLDAAIGDADHGTNMNRGF
                     EAALERLGEPGSPAEALKAVSTALISKVGGSAGPLYGTAFLRASSELGEEVSAAEAASA
                     LEAALAGVEQRGKAEPGEKTMIDALEPAARAAREAAGAERGVAEVLRAAADAAREGAES
                     TAPMTATKGRASYLGERSAGHVDPGAASTHLLLEAIAGSMEGQEG"
     misc_feature    12358..12360
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="gutsmash"
     CDS             12603..12995
                     /locus_tag="ctg14_47"
                     /transl_table=11
                     /translation="VAVGMVLISHSKQVAEGTVELVRQMAGDVSLAAVGGDAEGGTGTD
                     PDAIRQAVEGLQAREILLFMDLGSAVMSAETVLEMLDEDLKSRVHLVDAPFVEGAFSAG
                     VVASSGAGAEECLEAAEEARTVSKLH"
     CDS             13442..13951
                     /locus_tag="ctg14_48"
                     /transl_table=11
                     /translation="VETSKASQGILSDDMAGKREEIVDLLKKAYFMELETVMSYVTNSV
                     NPDGVRAEEVKESLEEDIQEELGHAQQFASRIKELYGVVPGSMDFKAEQKGLQPPEEQV
                     DVVHVIKGVIAAETGAIEHYTRVIEETEGVDHVTQDMVIAVLRDEQGHRKLFEGYLREY
                     EAMGLA"
     CDS             14190..14489
                     /locus_tag="ctg14_49"
                     /transl_table=11
                     /translation="VSQEYAGYRGLLSPSLVALFLGTFFTMIGFYLLLSVVPLYTESSG
                     GRSSEAGLATAAFMLSTVGVQVAMPAILRRFGYKRVLIAGQALLGLPTLAYSLAG"
ORIGIN
        1 acaaagagcc agagggggcg tgatgcagga tagacacggg gcccgcgagg acacggggaa
       61 cgtagaggac atgctgcgcg actcgcgccg gcgcacgctg gagctggtcg gcgacctcga
      121 cgaagagcag atgatggggc cgcagctcaa gatagtgaac ccgcccttgt gggagatagg
      181 gcacctggcc tggttccagg agtactggaa cctccgccgc cgcgacggca cccgcgacga
      241 gttctcgggc tccgagttcc tggagcggcc ggacgagatc tacaactccg ccgagataga
      301 ccacgactca cgctgggggg cggacctgct ctccacgtcc gggacccacg attacatgca
      361 gaacgtcctc gaccgcaccc tggaccgtct ggaccgggag ggtggccccg agctctccta
      421 ctactcccgg ctcgccacct tccacgagga catgcacgcc gaggcgttca cctacacccg
      481 gcacacccac ggcctgcccg cgccggagct ctccgactac gacccgcacg cgctggacgg
      541 ccagcccacg gggccgctcc cgggcgacgc cgagataccc ggcggcgagt tcatgctcgg
      601 ggccgaccct ggctcggtcg agcgcggcga ggtccccttc gtgttcgaca acgagaagtg
      661 ggcccatccc gtacaggtcg ccccgttcaa gatggctcgg ggccaggtaa cctacggcca
      721 gttcgcggag ttcgtcgaga gcggcgggta cgagaagccc gggctgtgga gcgaggcggg
      781 gtggcgctgg cgcgaggaga acgggatcga gcgtcccctg tactgggaga agcgcggcac
      841 cggagacggc gagtggcacc ggcggcactt cgaccgcctg gagccgatac cggagaacgc
      901 cgccgtgatc cacgtcggct accacgaggc cgaggcctac tgcaactggg ccggccggcg
      961 gctgccgacc gaggccgagt gggagctggc agcggcggca gagcccgctc cagacggcgg
     1021 aatctcctcc cgcaagcggc tctatccctg gggcgacaag ccgccggttc ccggagaccg
     1081 gcgggcgaac ctggacggca tcctgatggg gacggtggac gtggcagcat tccccgaggg
     1141 cgagagcgcc ttcggggtgc gccagatgct gggcaacgtg tgggagtggt gctcggacgt
     1201 gttccagccc taccccggct acgagcggga cccgtacaag gagtactcgg agccctggtt
     1261 cggagaccac atggtgctgc gcggcggctg ctgggctacc cggtccagga tgctccgcaa
     1321 cacctggcgc aacttctaca tgccggaccg ccgggatacc ttcgtcggct tccgcacctg
     1381 cgcacggtag ataccgctat gcatctccgg tctctcgccg ggcggtaagc aagaagctgc
     1441 gagggagccc gggcaggcct ctaggcggga ccgggtaagg ccagcgaccg tagctagcac
     1501 cgggctcacc gggctggacg gcccgggcgc gccagccgtg cccggcgagc agggattcgg
     1561 gatcgttcgt gccgaagcgc agcggcgagc ccagccgcga gaacgactcc agcaggggcc
     1621 acgccacagg cgagaagagg aagtctcggt tgatgaagtc ggctccgagc cggctgccgg
     1681 gcgcggagag ggtgcccacc ctgtcgagca gggcgtgtac ctcggctcgc cgcaggtaca
     1741 ggaagaagcc ttccgcgagc cacaccgagg gctcctccgg atcgtgtccg gcctcgttca
     1801 gggctcgcgg ccaccccccg ccggacaggt ctacgcctac cgggcggcgc ttacagttcc
     1861 cggggggctt tttgtgggtg agtaactcct ccttgagctc caggacctct ggcaggtcga
     1921 gctcgtacag tcgggtgccg gccggccact ccagccgaaa ggcgcgggcg tccataccgg
     1981 cggccagcaa tacgatctgg cgcgccccgc tttgacgcac agcgcgggct agaaactcgt
     2041 cgtagaagcg ggtccgcacc accgagaaca gccccggacc cgcgccgagg gtggtggccg
     2101 cgaggtccat cgtcctcagc cacgcgaagc cttcgggtcc ggcgaagtcg gcggccagcg
     2161 ggtcgtcgaa gagccggtcg gcccgcgcgc tctcccgcgc ccgggccgcg gccatccacc
     2221 tcgaagttag gcccgccgcg ctcggcatgg ggacctccag aagccggaca aaagagactc
     2281 aggacattat aaccaacccg ctaaacgtct ggtcccggcc gcctcaccct tccgaggagg
     2341 ctcggacgct ttcgagtgcc gaggggtctt ccaaggtgga gaggtcgccg gggtcgcggc
     2401 tctcggcgag agcctgtatg ccgcgccgga gcatcttgcc tgagcgggtc ttcggcaggg
     2461 cctcgacgaa gtgtaccgag gcgggccggg ctatcgcgcc gacctgtttg tccacgatgt
     2521 cctttacgga ctgctccagc tcggggcccg cgctctccgg gtcgccggcg acgacgtagg
     2581 cgaggaccac ctgacccttg tactcgtcct tcacgccgac ggcggcggcc tcggccacgt
     2641 cggggtgatc gcttatggcc tcctcgatct cccgcgtccc tagccggtgg ccggcgacat
     2701 tgatcacgtc gtccgagcgg cccaggataa agtagtggcc ctcctcgtcg cgggtgcccc
     2761 agtcgaaggt ggagtagacc tcctgcggaa agtcccggaa gtaggtctcg acgaaccgct
     2821 ggtcgtcgcc ccagatcgtg ctcatgcagc cggggggcag gggagggacg atggtcagca
     2881 ccccgcgctc gtccgggccg acctcctctc ccgtgccctc ctccaggagc cgcagatcgt
     2941 agccggcgca ggcgaagccc gccgagcccg gcttcaaggg gccatcctcg aggccgggga
     3001 gcatgctgga gaggatcggc cacccggtct cggtctgcca gtagttgtcc cggatgctca
     3061 cgccgaggct ctcggctgcc cagcgggagg tcggctcgtc gagcggctcg ccggcgaggt
     3121 acagcttgcg caagctggaa gtgtcgtgac gctgcatgta ctcggggtcc tgttttctaa
     3181 gggcccggat cgcggtcggc gaggtgaaca tcgtgtttac gccgtactcc tcgacgatgc
     3241 tccaccacac gccggggtct ggacgggtgg ggagaccttc gtacaccacg gtcgtcatgc
     3301 cgtggagtag cggcgcgtac acgatgtagg agtggcccac gacccagccg atgtccgagg
     3361 cggtgaacat cgtctcgccg ggctcggagt cgaagacgtc ccgcatcgag gccgcgaggg
     3421 cgacggcgta gcccccggtg tcgcgctgga tgcccttcgg cgtgccggtc gtgccggagg
     3481 tgtacaggat gtagctcggc tcactggact ccacccactc gaccgggacc tccgcacccc
     3541 agtgctcttt tcttagagtg gcgtagtcca ggtcccggcc ctcgacgacg ttcatgtccg
     3601 ggtcgaggcc gcggttgcgg atcacgacgc tcgggggcgg gtgctcggcg gtttcgagcg
     3661 cctcgtccac gagtggcttg taggggatca cgttcccgcc ccggctcccg gcgtcggcgg
     3721 tgacgagcgc cttcgggcgg gcgtcgtcta tgcgggaagc gaggttgggt gccgcgaagc
     3781 cgccgaagac tacggagtgt atggccccga gcctcacgca ggccagcatg gcgaagagcg
     3841 cctcggccat cattggcatg tagatcacga cccggtcccc gcgcccgaca ccgagacccc
     3901 gtagcgcggc ggcgaaggcg tttacctcgt cgtacagctc gcggtaggtg taggtctccc
     3961 gctctccggt ctcggtggag acgtagacta gggcggcctg atcggacctc tccgaaaggt
     4021 gccggtctac catgttgtag cagaggttcg tctcgccccc gacgaaccat ctagcgaacg
     4081 gcgggctcga gaagtccagc acctcgtccc actccttttg ccagtctatg agccgggcct
     4141 tctccgccca gaatgcctcc ggctcctcga cggaacgccg gtggaactcc ctgtactccg
     4201 cgatgctcat cctggaacct cctcggatta gctacctttc cctgacagga gtataacggt
     4261 gcggagatcg gcgcggtgta tctccgggtg cggccctcgg gtagcatagc tttgaagtga
     4321 gagagtggct ctacaagaag gacgagaaag gcgggccccg gcgctttctg agccaccggg
     4381 agttggcggc gtgggatgcg ctcaaggtgg gtagattcgc cgggccgccc ctggggctct
     4441 gcgtggtggc taccatattc gacccacagg agctcggacg gctagcgttc ctctcgctcg
     4501 gcctcatgtt actcgccttt tgtgtcgcgg tcgtggccgt gatgtacctg tacgtcgctc
     4561 tctcgggcgg cgtgatgggc cccgaggagc ggctgcgcta tcgggaacgg ctgcgcgagt
     4621 cccggcgggg tcgttggtag aggttaatta accagccgcg atcggagggc ggcggagaat
     4681 cggtccacta tgaggacgac gatgatcgtg gccccgacga gggtggcgac tttcgggtag
     4741 tcgaagagct gcatggagac caggatctcc tgcccgatcc cgcccgcgcc gacgaagccc
     4801 aggatagtgg ccgagcgcag gttgcactcc cactggtaca gcgagagcga ggtgacgctc
     4861 gccatcgcct ggggcatcct gccgaagata aacgccccga acccactcgc accggtctcg
     4921 tgcagcgcct ccaccggacg ttccggaacg gcttcgagcg tctcgctgta gagcttgccg
     4981 agcaccccgg cggagtgtac ggcgagcgcg agcatccccg gaaatggccc tagcccgagc
     5041 gccacgacga acacgagcgc ccacaggatg tccggcaccg aacggaacac gttcgtgagc
     5101 agccgggcgg cgtgatacgg cacggcgagc gcgagtcgcc gggcgcggct cgccccgacc
     5161 gtggacgcct cgcgggtgcc gagggcggcg agcgggaagg cgacgacggc cccaatcagg
     5221 gctcccagga aggccatctg gaaggtttcc acgacgccgg taaacgtggt ctggagggtt
     5281 gacgccgaga ggtcgggcgg gaacatctcg gagacgaagc tctggaccgg ctgcgccccg
     5341 gagaggagat ccaggaggtc gaaaccgacc ccgagcccgc tccagccggt gagtcccagg
     5401 atcacgagca cggcgaggct cgtcttccac gagaccctgg ggagtgcgcc gcctatctgc
     5461 ggggttttag agaccgatgg tctccgttca gtgcgaggtg acgccatctt gtcctccggt
     5521 aacgcggggt gatacgcccc ggggccccgt gccgtccggg gcttcggggt gtgggctcgg
     5581 gtggtacggg tcgccggagt agaccccggc gagcctctcg tccgtcagac cctccggccc
     5641 gccgtcgtag aagagccggc cttcccgcag ggccactatg cgcgggaagc gccgggccag
     5701 ctccacgtcg tgcaggttta ccacgagcgt cgagccttcc ccgttaagct ccgcgacggc
     5761 ctccagcacc cgctcggtgg tctgcgggtc caccgcggcg aacggctcgt cggcgagcac
     5821 cagacccgga cgctgcacga gcagccgcgc caccgcgacc cgctgctgct gaccgcccga
     5881 gatgtccgag gtccgtgagc gcgccagctc caggagcccg agacgctcta gcgcctcccg
     5941 gacccgggag gcgaggccgg cgtccggccc ggcggccagc atcttcaggg cccgccaccc
     6001 gccgatactc ccgacctccc cgaggccggc gttcaccccg acggggagct ggggcacgag
     6061 attgtatgcc tgacgcacga caccgacacg gctcctcaac tcctttagct cgcgccagga
     6121 gaggccgaag aggtcgtcgc cgccgatggt cacccgtccg ctacccaggg cgacgccgcg
     6181 ggtcaggagc ctgaacaggg tggacttgcc cgcgccggag gccccgatca cggccagcct
     6241 ctcgccaggc tttacggaga ggcttacgtg tttgagggcg ggggcgccgc cgtaggacac
     6301 ggtggcgtcg tccagctcga acccgaggga gtccctggaa ctcttggaaa cccttgaact
     6361 attgcccggt gcctcgttca aggagccgct actccgtggg ggtgagaagg tccagctccc
     6421 gggcctgctc ttccacctcg tcgtagtcgc cgggctctac cctctcgtag ccctgggccc
     6481 ggagaaggtc caggagctcc gggtcttcga gatccaggta tgcttgggcg acctcttccc
     6541 ttaggttttc gggcagatcg tcgcgcacca cccacgggta gccttccacc aggatggtct
     6601 gtataacccg gtaggagtcc tcgtctatgg tgccctgctc gacgaggtcc agcaggatgc
     6661 ggtactccag accacccgcg gccacgcgtt cgttggcgac ggcctgggcg gtggcgtcgt
     6721 ggccgccggt gtaggtgtac tcgccgaggt ccgtccggta gtccacaccg gcctcatcga
     6781 gcattatcga ggggtaaagt gagcccgagg tcgaggaggc gctgccgaag gcgaagtcct
     6841 tgccttcgat gtcctccacc tcttccacct cgccgtttgc cggggcgatg atcgcggagc
     6901 ggtatttggt gtcgccggtt ctggggttga tctcggtgac cagcgggctg atgtcagcgc
     6961 gctcgcgggc ctgcgcatac gtgagaccgc cgaagtaggc gagatccaac tcccccgagg
     7021 tcatcgcctc gaccacggcg ttatagctgg tggggacctc cagctccacg ggccggtcca
     7081 gctcccccga gaggtactcc tccagcggct ggtactgggc ctgtacctcc tcggggttct
     7141 ggttcgggat caaaccaacc gacagcgcct cctcgtcctg cgacgatccg cacccgacca
     7201 gcgccaggga gatcgccccc agggctataa cacccgccct acgtacgtta cgcctgcctc
     7261 tcaaagctcc gctctcctcc aaacttcgcg ccatacacgg aacccgggca acctcgtccg
     7321 tggcttatat gcctggtcag gccccgctaa acgtaccgaa ccgcaacgtc gtatatgtta
     7381 gcacgccctc tcgaaagctc cgtcccggcc tgctcgtata ccgcttctgg aaacggccga
     7441 acttgacacg ggtttcatta ttgaataggt taataaagta acataacgct gtgaggagtt
     7501 ggaggctagt ggctctcttc atggttctct ggtgtgatgg tccacggagg cgcaaggggt
     7561 gacggtggag gctggatcac gattctagag aggattttag agaaggagac ttctgatgct
     7621 gagagccctg tttattcgtg gcgcgccggg tggatcatgc gagtggcgga tgcaccgtga
     7681 gtgaggcgta caaagagccc gtagagtccg tagaggaggg ggccggggac catgcctcgg
     7741 tcgtcgtgct cggcggagac gccttcgagc tgttggagag gctccaggga tggaggcggc
     7801 ccccggtcta cgccaacgtg gatctcacga gcgggatatc gtctgaagcg cccggattgc
     7861 gctttctctc ctggcacgtg gagagtgtga ccccgacccg ccgccggatc atcgagctgg
     7921 cccggaaagt ctcttccctg ctcgccccgg gggtctcctg tgtctccacc agtgacaggg
     7981 gcctctgcgg tttctgccgt tactgtggtt accggggtta cgagtattac gagagccgtg
     8041 gatagccggg agcgttacac accgcccccg cctccggcgg tttttgactc atttgactcg
     8101 cctacctccg ctcgctacca tgcttccgga caacgaaaga tgcagaagct tggtcggggt
     8161 gaagagacca aagagataaa gccccgcacg aagaccctgg gctcgtccgg tgatcggacg
     8221 gtctatctgg tctgcccgtg cggggctttt gcgtagctcc gtgagggaga ggggggacga
     8281 tgcgatgagg ctccgctagg ctcttatgag ctttatgggc tcctgcgggt tctgtaatcg
     8341 gcccgccgtg tggggcgcag ggtaatggga aagtaacagg aaaaagaggg aaaagagaaa
     8401 aaagggaagg ggaagccaaa tggcgggtac acacatactg gctatagatc agggcacgac
     8461 ggggaccacg gtgctcgtgt tcaaccacga cggcgaggtc gtcggacgct cctactcgga
     8521 gttcacgcag cactacccga agccgggctg ggtcgagcac gacgcgaacg agatctggag
     8581 cgtcaccctg cgctgcatcg gcaccgcgct cggcgacgcg aacatctccg ccagcaagga
     8641 gctcgaagcc ataggcataa ccaaccagcg cgagaccgcc gtgatgtggg accggtccac
     8701 cggcgagccc gtacaccacg ccatcgtatg gcaggaccgc cggggcgcgg agctttgcga
     8761 cagcctcaac gatcagggct acggcccgat ggtccgcgag aagaccgggc tcaacataga
     8821 cgcctacttc tccggctcga aggtcaagtg gctgctagac aacgtagacg gcctgcggga
     8881 gcgcgcggaa cggggtgaga tctgcttcgg caccatagac tcctggctcg tctacaagct
     8941 aaccggcggc cgagagcacg tcaccgacta caccaacgcc tcccgcacgc tgctctacaa
     9001 tatcttcgac ctgcagtggg acgacgatct cctcgggatg ctcgaggtgc cgcgcgagat
     9061 actcccggag gtaaagccct ccagccacgt ctacggcaac accgacccgg aggccttctt
     9121 cagggccgag atccccgtgg ccggtatagc cggggaccag caggccgccc tcttcggcga
     9181 ggcctgctac gaacgcggga tggccaagaa cacctacggc accggctcct tcgccctgat
     9241 gaacacgggc acggagccca taaagagcga gggcgaactg ctgaccacca tctcgtgggg
     9301 catcggcgac gagcctgtgg agtacgcact ggagggcgcg atattcatca cgggcgctgc
     9361 ggtgcagtgg ctcagggacg gcctcggcat cataaaggac gcttcggaga ccgaggagct
     9421 tgcccgcagc gtggacgaca acggcggcgt ctactacgtc cccgccctcg tcgggctcgg
     9481 cgcgccccac tgggacccct acgcccgcgg caccatcatc ggcctgaccc ggggcacgac
     9541 caaggcccac ctcgcccgcg ccgccctcga aagcatggcc taccagaccc gcgacgcggt
     9601 agacgccatg gagcgggact ccggcataaa gctcccgagc ttccgcgccg acggcggggc
     9661 cgccgcaaac tcctggatga tgcagttcca ggccgacatc ctcggcgtcc ccgtcgaggt
     9721 ccccgacatc acggagacca ccgctctagg cgcggcttac ctcgccggca tagccaccgg
     9781 gttctggaag agccgccagg acgtcgccga caagtggcgg ctctccagcc gctacgagcc
     9841 ccagatgtcc gacgacgacc gcgagtggct ctacggccgc tggacgggcg ccgtggaacg
     9901 ctccaagggc tgggcccgcg aggccgtgga atccccgctc acctagccgg ccggtagacc
     9961 cgggaaaatc agggaaaacc aggaaaggaa gagcagagcc atgaagaagg tcctgaacgc
    10021 ccccgaccgg gcggtcgagg agatgctgcg cggcatggag ctggcccacg gcgggcgaaa
    10081 cggaaacgac ggagagagcg gcctcatacg ccgcctctcc ggccagaccg tggcggtgcg
    10141 cgccgacgcg cccgttagcg gcaaggtcgc catcgtaagc ggtggcggct ccggccacga
    10201 gcccgcccac gccgggtacg tcggtcccgg catgctcgac gccgcctgcg ccggggaagt
    10261 cttcaccagc ccctcgccgg agccggtgct agaggcgacg aaggccgtgg acggcggagc
    10321 gggagtgttc tacgtcgtaa agaactacac cggcgacgtg ctcaacttcg agatggccgg
    10381 agagctcgcc ggaaccgaag atatagagac cgactacgtc gtcatcaacg acgacgtggc
    10441 ggtcgaggac tcgacgcata ccaccgggcg gcgcggcgtt gccgggacgg tgctcgtgca
    10501 caagatctgc ggcggcgccg ccgacgacgg caagagcctc ccggagataa agtccctggc
    10561 cgcccgcgta aacgagaacg tccgctcgat gggcatggcg ctcacgagct gtgtcccgcc
    10621 cgagcgcggc gagcccatct tcgacatcgc cgaagacgag atggagctcg gcatcggcat
    10681 ccacggcgag cccggcaccg agcgccgcaa gatagagccc gcagacagca tcgtggacat
    10741 gctcctggag aaggtgctcg gcgactccgt ggactactcc ggatcaggcg gtcaagacgt
    10801 ggccgtgatg gtcaacggca tgggcggcac gcccctgatg gagctatacg tagcctacgc
    10861 tcgcgtccat gacgtgctcg cggagaacgg gataaacgtc cacggtgcgc cctacgtcgg
    10921 cgagtacatg acctcgctgg agatggccgg attctcggtg acgctgctca agctggacga
    10981 cgagatgaaa cgctacctcg cagccccgtg cagcgtcgcc gccggcgggt tgttctaagt
    11041 ctgttccaaa cacgagctta cgaatcccta tgatcctgat aaccctgatg aaaggagtct
    11101 cgcgaagtgg actttagcgt atacctcgcc gagttcgtcg gcaccctgat actggttctg
    11161 ctgggcgacg gcgtggtcgc cggcgtacta ctgagatact ccaaggcgga ggatgcgggc
    11221 tggatcgtca ttaccttcgg gtggggcctg gccgtggccc tggcggtcta ctcagtaggc
    11281 tgggttagcg gcgcccacat aaacccggcg gtcaccgtgg gtctggcctc gataggctcc
    11341 ttcgactggg ccatggtgcc gggatacata ctggcccaga tgctcggcgc gttcaccgga
    11401 gccgtgctgg tgtggctcgc ctactacgat cactgggggg ccaccgagga tgccggcctg
    11461 aagctcggcg cgttctgcac cgcgcccggt atccgcaaca ccgtgccgaa cttcattacc
    11521 gaggtcatcg gcaccgccat gctcgtcttc ggcgtcgttg ccatcggcgc gaacgcgacg
    11581 gcgataggct cctccggggg cgtggacctc gccgccgtct tctccacggg tatagcgccg
    11641 ctgctcgtcg gcttcctggt gctcgccatc gggctctcac tcggtggccc gacgggctac
    11701 gccatcaacc cggcccgcga cctcgggccg cgtatagccc acgccgtgct cccgatagcc
    11761 ggcaagggtg gctcggactg gggctactcc tggataccgg tggttgcccc catagtcggc
    11821 ggcgttatcg gcgcggtggc ctacaatatc ctcgggttct aggagacggt tcgtggcggg
    11881 cccactataa ggcccgccgc ttcatggatt ttcgtagact tccctagact ttcataaacc
    11941 tcgtaactca acccggaggg agggtgtaga gatttgggcg ccaccgagag caccgtggcc
    12001 gccgtgcggg cgatggccgc ggcgatgaag gagaaccgcg agcatcttac ccagctggac
    12061 gccgccatag gcgacgccga ccacggcacg aacatgaacc ggggcttcga ggccgccctc
    12121 gaacgcctgg gagagcccgg atctcccgcc gaggcgctaa aagcggtctc cacggccctc
    12181 ataagcaaag tcggaggctc cgcgggccca ctctacggca cggcctttct ccgggcctcc
    12241 tccgagcttg gcgaggaggt ctctgcggct gaagccgcct cggcactcga agcggcgctc
    12301 gccggggtcg agcagcgtgg aaaggcagag cccggtgaga agaccatgat agacgcctta
    12361 gagcccgccg cccgcgccgc ccgggaggcc gccggggcgg agagaggcgt cgcggaggtc
    12421 ctccgggccg ccgcggacgc cgcccgagaa ggggcagagt ccaccgcccc gatgaccgcg
    12481 accaagggcc gcgccagcta tctcggcgag aggtccgccg ggcacgtgga cccgggggcc
    12541 gcctcgacac acctgctgct ggaggccata gccggctcga tggaaggaca ggagggttag
    12601 ccgtggcagt cggaatggtt ttgatctcgc acagcaagca ggtcgccgag ggtaccgtgg
    12661 agctcgtacg ccagatggct ggagacgtct ccctggccgc tgtcggcggc gacgcggagg
    12721 gcggtaccgg caccgacccg gacgctatcc gccaggccgt cgagggcctc caggcccggg
    12781 agatactgtt gttcatggac ctcggcagcg ccgtcatgtc agcggagacc gtgctcgaga
    12841 tgctggacga agacttgaag agccgggtac acctcgtaga cgcgcccttt gtcgaggggg
    12901 cattctctgc cggggtggtc gcctcctccg gcgccggtgc cgaggagtgc ctggaggccg
    12961 cagaggaggc ccgcaccgtc tccaagctcc actaaaaaac ctcccctggc cctcccagaa
    13021 ctgtggcccg tgtcctggat cgcccccggc gtccgggacg tttcggggag accgtgatac
    13081 cgcgccgcgc ggcggagctc ctttccaggt tgttcgcggg gccactggga ccccatgcgc
    13141 ttctggcggt ctctatacct cttggcacct actggatggc cccggtagcc ctccgatagg
    13201 ccaagctttc cctcgcgtgg tcccctcatg cacggccccg gtgcgagctc tgcggcacac
    13261 gtctacgggt ggtcgtgagg ggtgtgtaga gccccgaaaa agccctgcga gaggttgcga
    13321 gatacccggg aggtgctaca ctacgtgact aggaataaaa ctaagaactg ttcttgatta
    13381 ttcgtttcga gtagcggttc actgttagta ttagggcaag cgatagacca ggaggtcgaa
    13441 agtggagacc agcaaggcga gtcagggcat tctgtcggac gatatggccg gtaagcgcga
    13501 ggagatcgtg gatcttctga agaaggctta cttcatggag ctcgagacgg tgatgagcta
    13561 cgtcaccaac tccgtgaacc cggacggcgt gcgggccgag gaggtcaagg agtccctgga
    13621 ggaggacatt caggaggaac tcgggcacgc ccagcagttt gcctcgcgca tcaaggagct
    13681 ctacggtgtg gttccgggtt cgatggactt caaggccgag cagaaagggc tgcagccgcc
    13741 ggaggagcag gtggacgtgg tacacgtcat aaagggcgtg atcgcggccg agaccggggc
    13801 catcgagcac tacacccgcg ttatcgagga gaccgagggc gtggaccacg ttacccagga
    13861 catggtaata gccgtcctgc gcgacgagca gggtcaccgc aagctcttcg agggttacct
    13921 gcgcgagtat gaggcgatgg gcctggccta aacagtttaa ataggctaaa tagcccggat
    13981 aacctggata tacccaggga ctccaaaagt ccgagcccgc gggtctagcg gatcggataa
    14041 ggggacccgg ccttgaggcc gggtcccctt taatcgtgcg ttatcgtgcg ccggttggtg
    14101 atggttggtg ccgggcggtg cgcggtaaag gagtttagac tgcctcgtgt cacgtatccg
    14161 gcggcgcacg aggagcgggg aggaggcttg tgagtcagga gtatgccgga taccgggggc
    14221 ttttgagccc ctctctcgtt gccctgttcc tcggcacttt ctttaccatg atcggcttct
    14281 acctgctgct ctccgtggtg cccctgtaca ccgagagctc cggtggccgg agctcggagg
    14341 ccgggctggc gacggcggct ttcatgcttt ccaccgtggg ggtgcaggtc gccatgcccg
    14401 cgatactgcg gcgctttggt tacaaacgtg tgctgatagc gggccaggcg ctgctcgggc
    14461 tgccgacgct ggcctatagc ctcgcaggct a
//
