LOCUS       NZ_CP028105.1          24230 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP028105.1 Fusobacterium ulcerans strain ATCC 49185 chromosome,
            complete genome.
ACCESSION   NZ_CP028105
VERSION     NZ_CP028105.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-13 23:32:31
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 213901
            Orig. end    :: 238131
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..24230
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[223901:228131](+)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14230
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..24230
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..24230
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             50..1252
                     /locus_tag="ctg1_208"
                     /transl_table=11
                     /translation="MSKNIENDAHDEKYILSVKNLTKLYGLNKNEAVKMLKAGAEKSEV
                     FKKTGVTSAIWDMSFDVKQGEIFVIIGLSGSGKSTVIRCLNRLHNPTSGNILFDGKEIS
                     KFSQKELIDFRRNKISMVFQNFGLMSHRDVISNIEYGLEIKGISKEEREKKAMEVLKMV
                     GLEGLEHESINSLSGGMKQRVGIARALANDPEILLMDEPFSALDPLVRSDMQFELLSIQ
                     KKLKKTIIFITHDINEAFKLGDKVAIMKDSRLIQLDTPENMSANPADDYVRQFIDSADK
                     TKVISVKQIMFNPSCIIRLKEGAGIAIREMKSNRVSSAYVIDNHMKFLGIITIDSALKC
                     RNENGFLSDYIIGEIPTTSSDTLINDILPIAVNTKFPIAVIDDGELMGIVSKASILSTL
                     I"
     CDS             complement(1519..4101)
                     /locus_tag="ctg1_209"
                     /transl_table=11
                     /translation="MKKRIFWGQLIAALLYIGNTTFSQTIWTDADFTTPKGHTWVNSGN
                     WDYGGDVHIQNVNEVIFESNMSGKPGTGVLSIETGGKLTADGMVIVNQLGPTTGDAVLV
                     TDGGKAYFNGGLTANIMNSNNDYYAIGVIRGNSQLHVKGDTNINANFEKGYGLYLGEGT
                     TNSFSKNDSGNGSVNIYAGKIGIYSLGNTDFNQDVNISLNSNGATGIISNTTNTLSTTN
                     FNGFVTVENNSISDNTSTAYGVAVSNANGILNLNAGGKIVFGDNYTNGNEIGIYANKGI
                     INITGDLTVQSNSGGIQAVFYTTNGGRITAVDSVMDLKGNMYANNSSEITVAMNSGSLW
                     EGASYIGNGSTVDIKMTGSKWKMTEDSTVTNLDILSGTTVYLNAAPDYSNFIGRTLTIT
                     ENYHGNGGTIVFNTQLEDDNSVTDKMIVEGDTSGTTKVRVNNMGGQGAHTENGIELISI
                     LGISDGEFVKDGRIVAGAYEYFLNRGDGITTDSNNWYLTSTIPSIIPPPVTPPDTEDPI
                     DPEILDPPLGPELPNVIEPIYRPESGSYLANARAVNSLFVHTLHDRLGETQYTDALKNG
                     EQVSSIWVRNVGGYGTFRDGSNQLKTRNKKNVIQVGGDIADWSSNENNRYHLGIMAGYG
                     FNHSKTESNKTSYTSKGETEGFNLGVYGTYYANENDKSGFYADTWLTYSWFDNEVRGDE
                     LEKEKYKSQGITASLESGYSFKIKSDDSDRKTYYIQPKAQIIYMGVDTDDHTEANGTKV
                     ETKGDGNIQTRIGARVYVNHFNPADRDNSKEIQPFVEANWIHNSKDVNVSMDDINNKIK
                     GTKDIGEVKVGTEVKLNPSFNVWGNVSHQWGGSGYRDTKVTIGIKYSF"
     CDS             complement(5184..6446)
                     /locus_tag="ctg1_210"
                     /transl_table=11
                     /translation="MDNSMEKIGSKTKLLLGAQHVLAMFGATVLVPFLTGLNPSIALIA
                     AGAGTLIFHFCTKRIVPVFLGSSFAFIGALSLVLKDEGIGAVKGGVIAAGFIYLLMAYL
                     VKVFGVEKIKSFFPPVVTGPIIMVIGLRMSPVALSMAGYANGKFDPKSLIIALVVIISM
                     ISITIMKKSFFRLVPILISVTLGYVVAMFMGLVSFEPIAKANWIGLSAEAANDLFTLPH
                     FSVSAVLAIAPIALVVFIEHIGDITTNGAVVGKDFFKNPGIHRTLMGDGVATIVAGLLG
                     GPANTTYGENTGVLAVTKVYDPSILRIAACYAIVLGLLGKFGVILQTIPAPVMGGVSII
                     LFGMISSVGARTLVDAGLDFSNSRNLIIASLIFVFGIAVDNIVIWKTVSLSGLALAALA
                     GVVLNKVLPLDREVAINKKID"
     CDS             complement(6512..6889)
                     /locus_tag="ctg1_211"
                     /transl_table=11
                     /translation="MLKEGMSLTLEKIVNENETAAKIASGALNVFATPILIAFMENASF
                     ELVQKELPAGETTVGISVDIKHLKANLVGDKIKCVSVLEKIDGKKLDFSVKVYHGDTLV
                     GEGKHGRFIVNEEKFLSKLKG"
     CDS             complement(6953..7210)
                     /locus_tag="ctg1_212"
                     /transl_table=11
                     /translation="MLKVWIVIGISLLIIAAYVGILLASSTKESDDKYVVGILKTGYKV
                     FEYFNRKKNNLGVYFSYAILWVGYMVLNGRKPKLKKDTMK"
     CDS             complement(7233..7865)
                     /locus_tag="ctg1_213"
                     /transl_table=11
                     /translation="MKTAYVFFNGQLEGSREFYIKLLAKEKGDIYCADGGANHLETLGI
                     LPLEIWGDLDSVTKEIIEKYRNNKVTIKKFPKDKDYTDGELILQHISKMDYDKITIIGG
                     LGGRIDHLLTNLNLIFKFKNLMFVTEKEKIFSIEKKAELTELNGKTISFVPFSEKVEGL
                     TLEGFKYPLNKYTLHQGDSICMSNVAVEDRCRVTFDTGKLMGIVLNG"
     CDS             complement(7881..8705)
                     /locus_tag="ctg1_214"
                     /transl_table=11
                     /translation="MKKIKLVFIYFLLAMTIFAQEGYIASFNTLRLGKSQKDYILTAQA
                     LEMFDIAGLIEVMDAEGVEKLINALEKVSGEKWDYHISPYPVGKNSYKEYFAYVWKKDK
                     VEFLKERGFYKDTEEKFARPPYGADFKIGEFDFTFVLVHSVFGKNESARRAEAFKMNEV
                     YDYFQNLDLKENDVIIAGDFNLSGFDESFEKLLSHPDKIIYALSPVIKTTLGKKSLASS
                     YDNMFLSTIYTKEFTGKSGALDFTQGQYRLMKDKISDHLPIFIVVKISEDDD"
     CDS             8861..9577
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_215"
                     /sec_met_domain="HAD (E-value: 6.2e-21, bitscore: 73.2,
                     seeds: 107, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIAAFFDIDGTIYRNSLLTEHFKKLIKYELLDFREYDTRVKEAFK
                     LWDERVGDYDKYLLGLTQTYVDAIKGLSTKYNDFVADQVVELKGNRVYSYTRRMIKWHK
                     EQGHKVIFISGSPDFLVSRMAKKWKADDFCGSVYHIKDGVLSGKISPMWDSENKMKSIH
                     MFCQKYGIDLMKSYAYGDTHGDYSMLLSVGHPRAINPSLELLNSIRESDYLKKNTEIII
                     ERKDIIYKVHSDVETL"
     CDS             9604..9942
                     /locus_tag="ctg1_216"
                     /transl_table=11
                     /translation="MTVRLFYFIISFMFMFFTSNFDIQEKHSAFKDLPQNILLLGKIES
                     SREYSFIKIDKIELADRTNLKNPIPAFLEMTEIVTEEPCINTVIYPQKDSLTFYTILER
                     YGSRILLI"
     CDS             10001..14230
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_217"
                     /sec_met_domain="HGD-D (E-value: 2.9e-47, bitscore: 159.6,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 4.1e-35, bitscore:
                     119.1, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MREFHIGMDVGSTTIKIVCLDEKDNIIYSIYQRHLSNVRETTKKM
                     FDEFLEHIKSNFGEDIRYRISITGSSGMGISSWIGIDFVQEVIACIKSIETLIPETDVA
                     IELGGEDAKITFLKNDMDQRMNGSCAGGTGAFIDQIATLLDTDASGLNELAKGFDSIYP
                     IAARCGVFAKTDIQPLINEGVKKENIAVSVLQAVVNQTITGLACGKKITGKVAFLGGPL
                     FFLSELRNRFIDTLKLTPEDVVFPENSQLFVAQGAAFLAKENESVFSYDELKTKIERLN
                     EKDTSDTSRLQPLFENEDALNEFLERHEKEKIETRDLSTYEGNAYLGIDAGSTTIKVVL
                     ISEEKEILFSHYSHNKGNPLDNIIATLKNLYSKMSEKVIIKGSCVTGYGESLIKAALRV
                     DIGIVETMAHYKGSQFFQPNVDFILDIGGQDMKCLKIQDGIITSILLNEACSSGCGSFL
                     ETFAHSLGMDILEFSRLGMESKSPADLGTRCTVFMNSKVKQAQKDGVEVSDISAGLSYS
                     VVKNTLFKVIKIKNKDELGKNIVVQGGTFLNNSVLRAFELVSERNVIRPNVAGLMGAFG
                     AALIAMEQAEESSTIMTLDELNNFNCTTNLTRCKLCNNHCLLTIHKFKNGETFISGNRC
                     DNPLGKMKKNTAPNMFDYKYNRLFNYTPLEPSKATRGEIGVPRVLNFYDSYPFWFTLLT
                     HLGFRVIISDDSSKKLYEKGIDTISSDSICYPAKLVHGHIVDLIEKGVKRIFYPCVIFE
                     EKEDIKSSNQFNCPIVMSYPEVINNNMDILKEKHIDLILPFFSFESKEVLYKTVFEEFE
                     RFGITKSEAKMAVDAAWEEKYNFRKDMRNKALEIIADLERTGKTGVVLCGRPYHCDKEI
                     HHGIPNIINSFGIAVLTGDAVASLASLDEELRVIDQWTYHSRLYRAAAYVGKSSCLELI
                     ELNSFSCGIDAVTTDQVEEILANHGKVHTLLKIDEISNLGSVKIRIRSLLAALDYKKNA
                     LRSSLKKKIEYKKAQFTKKMKKEYTILAPQMAPMHFKLLKTAFKAEGYNLEVLEETQEA
                     LDCGLQYVNNDACYPSILVIGELIAALKSGKYDLDKTAVMISQTGGSCRATNYVGFLKK
                     AIRDSGFEKIPILSLNASGFEKQEGFSITLPFAHKCLIAVSYGDILMKLLYHVRPYEKI
                     KGSALELYEKWNEKVKENIANGKFSQFKSNINAIVEDFSKIEVSDEKKIKVGIVGEILV
                     KFSPFANNNLADFIEAEGGEVYTSSLMSFVKYCIYSDIFITERFKGKIAAMKLKAALWV
                     IDQYTKVLNNALQKNPRFGHEDSIQDLAKKTSQYISIGNQSGEGWFLMGEMIEFIEKDV
                     PNIVCVQPFGCLPNHITGKGMIKKLRSEYSNVNIAPIDYDPAYSEVNQLNRIKLMLSVA
                     RKNLKNS"
     CDS             14296..15402
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_218"
                     /sec_met_domain="Aminotran_5 (E-value: 2e-33, bitscore:
                     113.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LYKANYLMMTPGPTMVRENVLKARCSFFGNPDLDPNFFAFYEELC
                     KKTGKLFGAKKAQTIIMNGEGMLGLDTACASLTEPGDKVLVISNGIFGEGFKGLVETYG
                     GEVTLFETDVKKALDIDKLRIFLEKNKDFKYATMVHCDTPSGVLNNVEVICKILKSEGI
                     MTVVDSVAAVGGVQLEVDEWGIDIALGGSQKVFSAPSGITIMTVSNDAWEAIENRKTPI
                     ASFYCNLSLWKNSVKEQLFPYTMPASDLMAFDVAIDNIYKEGVEKVRERHYTAAEYVRT
                     RLMDMGVDLYLKNGYSPTVTAFCLPEGYNCKEVSDYLLHNFEVMIADSYSYLSNKVLRI
                     GHMGENARFYRLDYTLKAIEKTLRVLKK"
     CDS             15548..16276
                     /locus_tag="ctg1_219"
                     /transl_table=11
                     /translation="MCDFDKNNKMPLYGQLMNFLLSEIECDKFKEHEKIPSERDLCDKF
                     NLSRDTVRQAIFQLEKMGYIYKKHGKGTFVAQKQLKPDLYKFYDFTEEMKKLGKEAVSK
                     VLSFEIIPADKYISKALKIKENSNVHRITRLRLVDSIPLIFEKAYLSTEKFDFFSIDEL
                     SNSSLCNILKNRFSVKFSKGEETFYPITPDDEITRYLNLMKFQPVIKIERTTFEDEIPV
                     MFTERIIRGDKFKYTITTSF"
     CDS             16445..16879
                     /locus_tag="ctg1_220"
                     /transl_table=11
                     /translation="MKITQETNCAIKTILYLSTLQKGEISPAKTIGKSIGFSDKFVLKV
                     LRPLTSANIVLPFRGVTGGYCLGKTTDKITLFDVIVAVQNDINILTVMKNMSKKDIKKD
                     EIFSIFDQIQELEKKILKKITFDMIINNKVNLKNILEDTL"
     CDS             complement(16942..17493)
                     /locus_tag="ctg1_221"
                     /transl_table=11
                     /translation="MTNQYNKDGKKEGLWVKTYDNGRIQEEKNYVNGIREGEYKSYYMN
                     GQVETHKFYKDGNIHGVYETFYSDGKLSSRRTLVNGETVGLYEEFFPNGKLKKSSEHVS
                     NSTTTKNVKYFPNGQVKLDVNFKNGAMYGSYKEYFSNGVLYIECNYGDNGKLDGVYKEY
                     DAEGKLVKECHYSNGSEQFR"
     CDS             complement(17588..18712)
                     /locus_tag="ctg1_222"
                     /transl_table=11
                     /translation="MSGVILKNIEKVYPNGFKAVHGIDLEIKPGEFMVLVGPSGCAKST
                     MLRMIAGLEEITEGELWIEGKLANKLPPKDRGIAMVFQNYALYPHMTTYENMAFGLKMA
                     KFPKKEIDKRVRETAERLEISDILDRKPKEMSGGQKQRVALGRAIVREPKVFLFDEPLS
                     NLDAKLRVSMRVRITQLHKELLSEGKETMMIYVTHDQVEAMTMGDRICVLNKGKVMQVD
                     TPMNIYNFPVNKFVAGFIGSPAMNIVEGELLEKNGEVLVKLDTDTYLILDKEKAEKAKN
                     NIGEKIWFGIRPENIKVSDENSQEKNRAQGVVSVVENMGNEVYIYFKIGEKEFTARAST
                     DVIKNISFGKKLFFDFNMLNIHIFHYKTEKNILK"
     CDS             19022..19903
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MTHFR"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_223"
                     /sec_met_domain="MTHFR (E-value: 9.3e-86, bitscore: 285.2,
                     seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISELFKNKKTVVSFEVFPPNTIYSLEDVYSSIDELAKLQPDFM
                     SVTYGAGGATRGRTVEIASKIKNDNKIEALAHLTCLGAKANEIDDILEQLRKNNIENIL
                     ALRGDKPKDGLPVEEGDFKYAQDLISYVKGRKDFSIGGAYYPEGHQETNDLLDLFNLKT
                     KVDSGTDFLISQIFFDNESFYRFRDKVDKLQINVPLVAGIMPVANAKQIRKITSMCGCS
                     IPEKFQKILNRYEDNPKALKEAGTAYATEQIIDLITSDIDGIHLYTMNKVDTAKKIMAN
                     IAHIREISGGSR"
     CDS             19903..23244
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) B12-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pterin_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_224"
                     /sec_met_domain="B12-binding (E-value: 5.4e-17, bitscore:
                     59.5, seeds: 91, tool: rule-based-clusters)"
                     /sec_met_domain="Pterin_bind (E-value: 3.4e-43, bitscore:
                     145.7, seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINELKKRVLVLDGATGTAIQKYNLTDEDFQGKKGCNEILNITRP
                     DVIKEIHTKYIEAGADIIETNSFNCNRISLKDYEIEDMSYTLSKKGAELARETADNFYK
                     TSGKKIYVAGSIGPTSKSLSLPMGDVPYEREINFDQMKKIYSEQIEGVIDGGVDCLLIE
                     TIFDGLSAKAALVAAEELFEKKNIQLPIMISATVNRQGKIFSGQSIESLITALDRPSII
                     SFGLNCSFGARDLIPMIKRIASFTDKYISLYPNAGLPNEEGEYEETPEITAGYLKELVD
                     EKKVNILGGCCGTHFSHIKAIADLVKDKEPRLPVSKENRYFLSGNEIYDFSNKFTIVGE
                     RNNVAGSKIFKTLIEEKNYIKALEIARSQIEKGAAVLDINLDDGLLIPHEEMERFLRII
                     QNDPIVSKISIMIDSSDFFTIETALKNIAGKSIVNSISLKEGEEAFRKKARIIKKYGAA
                     MVVMAFDENGQGVSYERKVEICNRSYKILAEEGVPSSDIAFDPNILTIGTGSEDDRYNG
                     LNFIKTVQWIKENLPQCSITGGLSNLSFAFRGNNPLRAAIHSLFIENAKEKGMNFAIMN
                     PGEKAPQLTSEEKNTILSLINGEEDSLDSILELAVKLKNASDLLKKNSSSAPKIIKNDF
                     DSLKDRIENALIYGGSTTFDTDINTAMETMTPLDIIQNILMKGMDKIGVLFEKGELYLP
                     QLIRSASVMNRAVDILKPHMKIEANIGIKGKVLMATVDGDVHDIGKNIAGTVLKCNGYE
                     VIDLGVMVSKEKILEEAVKNNVDIITLSGLISPSLKEMKKILSLLDISKLSIPVLIAGA
                     ATSKLHTAVKLEPFYQGKTFHTTDALDTLTIINKLIYGDRDLFITEKTKELRELCKVYL
                     NNKKDTSKISVSPKEDFTSEVIAPKQLGKQYIEFPLQKIEKYINWNFLLHNMKVKNTPL
                     EENTLNDAKYILEKMKENDIKVKCAFGIFPCTKDSDNLTIKDSDKNWSISFIRGEVKNN
                     DIGISDFFNENDFIGTFIISVNSSLFDEDNYMSIMESILLTRIAEAASEFMENYLKEEN
                     IWLPNIRPAIGYSSIPDHSIKKTIFEITEGERTGAYLTNNFAMSPLSTVCGIYISNPKS
                     FYFDLK"
     CDS             23299..23586
                     /locus_tag="ctg1_225"
                     /transl_table=11
                     /translation="MIVVYAKSIVPEKNIDKYLEIAKKLAEETRKEKGNIFYEMVQDKN
                     NRSVLAFIEKWENMEVLDKHMKTPHFTTFVPQLNELREGESELAIHEVLF"
ORIGIN
        1 accgtatcac tcaggcatgg atcaatagaa gcgaggtgaa gaaaaaataa tgagcaaaaa
       61 tatagagaat gatgcacatg atgaaaaata tattttaagt gtaaaaaatt taacaaaact
      121 ttatggactt aataaaaatg aagctgtaaa aatgcttaaa gctggagcag agaaaagtga
      181 agttttcaaa aaaacagggg ttacttctgc tatttgggat atgtcttttg atgtaaaaca
      241 aggagaaatc tttgttatta ttggactgtc tggttcagga aaatctacag ttattcgttg
      301 ccttaacaga cttcataacc ctacatcagg taatatatta tttgatggta aagaaatcag
      361 taaattttct caaaaagagc ttatagattt tagaagaaat aaaatttcta tggttttcca
      421 aaatttcgga ttgatgtctc acagagacgt tatcagcaat attgagtatg gacttgaaat
      481 caaaggtatt tcaaaagaag aaagagaaaa aaaggctatg gaagtattaa aaatggtagg
      541 acttgaaggt ctggagcacg aaagcatcaa cagcctttct ggtggaatga agcagagagt
      601 tggaattgcc agagctttag ctaatgatcc tgaaatactt ctcatggatg agcccttctc
      661 ggctcttgac ccattagttc gtagtgatat gcagtttgag ctgctttcaa tacaaaaaaa
      721 attgaagaag acaataatat ttattactca tgatataaat gaagctttta aacttggtga
      781 taaggttgct atcatgaaag attcaagact tattcagctg gatacacctg aaaatatgtc
      841 tgctaatcct gctgacgatt atgttcgtca attcattgat agtgctgata aaactaaagt
      901 tataagtgta aaacagataa tgtttaatcc ttcttgtatt attcgtttaa aagaaggagc
      961 aggtattgct attcgtgaaa tgaaaagcaa cagagtttca agtgcttatg ttatagacaa
     1021 ccacatgaaa tttttaggaa taataactat tgatagtgca cttaaatgca gaaatgaaaa
     1081 tggattcctt tctgattata taattggaga aatcccaact acatcttctg atacactaat
     1141 aaatgatata cttcctattg ctgtaaatac taagttccct attgcagtta ttgatgatgg
     1201 agaacttatg ggaatagttt ctaaagcatc tattctttca acactaatat agaatatgaa
     1261 aatatatagt ataaagcatg gttaaaataa ccatgctttt ttagttatta ctctgctgtt
     1321 tctataattt caattataaa ataacataaa gttactaaga tgttctaaat ttttattgta
     1381 aatacaattt taaatataat taagatttct tctattttct tctacacatt aaaacagcct
     1441 cctatgaaat atttacttta tcatagaaag ctgttattat ttttaattta cagaaattat
     1501 ttcgcaaaac ctaaaaatct aaaaactata ttttatacct atagtaactt ttgtatctct
     1561 atatccactt ccgccccatt gatgagagac atttccccag acattaaaac taggatttaa
     1621 ttttacttct gtccctactt ttacttctcc aatatctttt gttcctttta tcttattatt
     1681 tatatcatcc atagatacat ttacatcttt actgttatga atccagtttg cttcaacaaa
     1741 aggttgaatt tctttgctgt tatctctgtc agcaggattg aaatgattta catataccct
     1801 tgctcctata cgagtttgaa tatttccatc acctttagtt tcaactttag ttccatttgc
     1861 ttcagtatga tcatcagtat caacacccat gtatataatt tgggcttttg gctgtatata
     1921 atatgtcttt ctatcagagt catcgctttt tattttaaag ctgtatccac tttctaatga
     1981 agctgtaatt ccttgtgact tatatttttc tttttctaat tcatctccac gaacttcatt
     2041 atcaaaccag ctgtatgtca gccatgtatc agcataaaat ccagacttgt cattttcatt
     2101 agcataatat gttccataga ctcctaaatt aaatccttct gtttctcctt tagaagtata
     2161 agaagtttta tttgattcag tcttactatg attaaagcca taccctgcca tgattcccaa
     2221 atggtaacga ttattttcat tactgctcca gtctgctata tctcctccta cctgaattac
     2281 attcttttta tttcttgttt tcaattgatt tgaaccatct ctaaatgtcc catatcctcc
     2341 aacatttctc acccagatac tagatacctg ctctccattc ttaagagcat ctgtatactg
     2401 cgtttcacct aaacgatcat gaagagtgtg aacaaataga gaatttaccg ctcttgcatt
     2461 tgcaagataa cttccagatt caggacgata aataggttca attacattag gcaattctgg
     2521 tcctaatggt ggatctaaaa tttcaggatc tatcggatct tctgtatctg gtggtgtaac
     2581 tggtggtgga ataatagaag gaatagtact tgtcaaatac cagttattac tgtctgtagt
     2641 aattccatca ccacgattta aaaaatattc ataagctcct gctacaattc ttccatcttt
     2701 tacaaactca ccatctgaaa ttccaagaat tgaaataagt tcgattccat tttctgtatg
     2761 agctccttgt ccacccatat tattaactct aacctttgtt gttccagaag tatctccttc
     2821 tactatcatt ttatcagtaa cagaattatc atcttcaagc tgagtattaa aaactattgt
     2881 accaccattc ccatgataat tttcagttat tgtgagagtt cttccaataa aattactgta
     2941 atcaggagca gcattaagat aaactgttgt tccagataga atatccagat tagtcactgt
     3001 tgaatcttct gtcattttcc atttacttcc agtcatttta atatcaacag tactcccatt
     3061 tcctatataa gaagctcctt cccaaagaga gccgctattc attgctactg ttatttcaga
     3121 actattatta gcatacatat ttccctttaa atccataaca gaatctacag cagttattct
     3181 cccgccattt gtagtataga aaacagcctg tattcctcca gaattacttt gaacagtcaa
     3241 atcacctgtt atatttataa ttcctttatt agcatatatt cctatttcat ttccattagt
     3301 gtaattatct ccaaatacta tttttccacc agcatttaaa ttaaggattc cattagcatt
     3361 agatacagct actccataag cagtagaagt attgtcactg atagaattat tttctacagt
     3421 aacaaatcca ttaaagtttg tagtagataa agtattagtt gtattggaaa ttattcctgt
     3481 tgccccattg gaattaagag aaatatttac atcttgatta aaatctgtat ttcccagact
     3541 ataaattcct atttttccag catatatatt tacgctgcca tttccactgt catttttgct
     3601 aaagctgtta gtagttcctt ctcctagata taacccatac cccttttcga aattggcatt
     3661 gatattagta tctcccttaa catgaagctg tgagttccct ctaataactc caatagcata
     3721 ataatcatta ttactattca ttatattagc agtaagtcct ccattaaaat atgcctttcc
     3781 tccatcagtt actaatactg catcaccagt agtaggtcct agttgattta caattaccat
     3841 tccatcagct gtaagtttcc ctcctgtttc tatacttaac acgcccgtgc caggttttcc
     3901 agacatattt gattcaaata ttacttcatt tacattttga atatggacat ctccaccata
     3961 atcccaattt cctgaattta cccaagtatg ccccttaggt gtagtaaaat ctgcatctgt
     4021 ccaaatcgtt tgagaaaatg ttgtgtttcc tatatataga agagctgcaa tcagctgtcc
     4081 ccagaatatt cttttcttca tttagttctc ctaattatat taaaataaaa aataaaattc
     4141 tccattaaag tacccttgaa atatcatgta tactttacat caacagcaat tatgctttct
     4201 actaaataat atttatattt ttatccctcc taattgttat cacaggagta tttttcccca
     4261 aagaaattta tccatgacta ttcatatata ctttctattg ctgcattatc caaagatgtt
     4321 tttaatatct gtgatttttt attttaaaaa attttaagta ttataattta taactaatct
     4381 ttatttttct ttttaaaatt ctttttttaa tgacatttat tttttctaaa acattcttaa
     4441 aacaaaatat ttattcgtgt aaattcgaca attaaattaa catacattaa atttaatatt
     4501 tttgtatgtt aaaaaaatgt gataattatg ttgaaaatta taaaaaaata atgagaacat
     4561 tattaaaaat ttatttattc aatcaaaaaa atatatttaa agaatacatt taaaaactta
     4621 taagttaata ttcgacctgg aaaactttga ataaagagga aatgaaaaga agatttaaaa
     4681 actttttaat taatattcaa aaaataaaaa agaaggtata tttcaacctt cttttctttt
     4741 taaaaaactt ataagttact agtcaatctt aaaatttata aaataccatt aaataaacct
     4801 gtatttaaaa acttatcaag ttactagtca attttgtatt agctaacaga tggggaagag
     4861 cagcatttga tttaaaaact tatcaagtta ctagtcaatt tatctactgc ttttatcttt
     4921 tcagcaccac ttaatttaaa aacttatcaa gttactagtc aatattcagc aattcacaac
     4981 ttcttttttc ctttagcttc tccattgctc taattatacc actttatatt tatttttcca
     5041 acctaaacaa agattttttt catttttatt tttctcttct atttatatct ttatttctta
     5101 acttaatttc cattggtatc ttttcccttg gaaaataaaa aatccatcaa tcataaattt
     5161 tgcatgatca atggattttc aaattaatct atttttttat ttattgctac ttctctatct
     5221 aaaggaagaa ccttatttaa aactactcct gcaagagctg caagtgcaag tccagaaaga
     5281 gaaactgttt tccagataac aatattatct actgctattc caaatacaaa tattaatgat
     5341 gctatgataa gatttcttga gttagaaaaa tccaatcctg catctactaa tgttcttgct
     5401 cctactgatg aaatcattcc aaacaatatt attgaaaccc ctcccattac tggagcaggt
     5461 atagtttgaa ggataacccc aaatttacct agaagtccta aaacaatagc ataacaagct
     5521 gctattctca aaattgatgg atcataaact ttagttactg ctagaactcc tgtattttct
     5581 ccataagtag tatttgcagg tccacctaaa agtcctgcca ctattgtagc aactccatct
     5641 cccataagtg ttctgtgtat tccgggattt ttaaagaaat cttttcctac aacagcacca
     5701 tttgttgtaa tatctccaat atgctcaata aaaactacta aagctatagg agctattgca
     5761 agtactgcac ttacagaaaa gtgaggaagt gtaaaaagat catttgcagc ttctgctgaa
     5821 aggcctatcc aatttgcttt tgcaataggc tcaaagctta caagccccat aaacatagcc
     5881 accacatatc ccaatgttac agatattaaa attggaacta gtctaaaaaa tgattttttc
     5941 attattgtaa tacttatcat agaaataata actaccaaag caattatcaa gcttttagga
     6001 tcaaacttac catttgcata tcctgccatg ctcaaagcta ctggactcat tctaagccct
     6061 attaccatta taattggtcc tgttactact ggcgggaaaa aagatttaat cttttctaca
     6121 ccaaaaactt ttaccaagta agccattaac agataaataa atcctgctgc tataactccg
     6181 ccttttacag ctcctatccc ttcatctttc aatacaagag ataaagctcc tataaacgca
     6241 aaagaagatc ccaaaaatac tggtactatc ctcttagtac aaaagtgaaa tatcagtgtt
     6301 cctgctcctg ctgctataag tgcgatagaa ggattcaatc cagttaaaaa aggaactaaa
     6361 actgttgctc caaacattgc aagcacgtgt tgtgccccta acagaagctt tgtcttgctt
     6421 cctatttttt ccatgctatt atccattttt ccccctttta aaatatatta ttaaaattta
     6481 tttactcctt aaaaaaagga tagtactggg actacccttt taatttactt aaaaatttct
     6541 cttcgtttac tataaatctt ccatgctttc cttctccaac tagagtatct ccatgataca
     6601 cttttacaga gaaatcaagt tttttaccat caattttttc aagaacagat acacatttaa
     6661 ttttatctcc tacaagatta gctttcaaat gctttatatc tactgatatt cctactgttg
     6721 tttctcctgc tggaagttct ttctgtacca gttcaaatga ggcattttcc ataaatgcta
     6781 taagtattgg tgttgcaaaa acatttaaag ctccagatgc gatcttagct gctgtttcat
     6841 tttcatttac tattttttca agtgttaagc tcattccttc tttcagcatt ttatcctcct
     6901 gatattaaat tctcgaaaaa ttatactaca ataatgtgct tctgtcaata gtttacttca
     6961 ttgtatcttt tttcagttta ggttttcttc cattcaagac catatatcct acccatagaa
     7021 tagcataaga gaaatataca cctaaattat ttttctttct attgaagtat tcaaatacct
     7081 tatatcctgt ttttaatatt cccacaacat atttatcatc tgattctttt gttgaactcg
     7141 ccaaaagaat tccgacatat gctgcaatta ttaataatga tatccctata actatccata
     7201 cctttaacat atgctccccc tcctacagta atttatccat ttaatactat ccccatcaat
     7261 ttccctgtat caaaagttac tctgcacctg tcttctacag ctacattgct catacagatg
     7321 gaatccccct gatggagtgt atatttattc aatggatact tgaatccttc taatgtaagc
     7381 ccttcaactt tttcagagaa aggaacaaaa gaaatagttt ttccatttaa ttctgttaat
     7441 tcagcttttt tctcaataga aaatattttt tctttttctg tcacaaacat aagattctta
     7501 aatttaaata tgagattcag gttagtcaat aaatgatcta ttcttcctcc cagtcctcca
     7561 attatagtaa tcttatcata atccatcttg gaaatatgct gtaatatcaa ctcaccatct
     7621 gtataatctt tatccttagg aaattttttt attgttactt tattattacg atatttctct
     7681 atgatttcct ttgttacaga atcaagatct ccccatattt ctaagggtaa aatccctaaa
     7741 gtctctaaat ggttagctcc accatcagca caataaatgt ctcctttttc tttagccaat
     7801 aattttatat aaaattctct gctcccttca agctgtccat taaaaaatac atatgctgtt
     7861 ttcatcgtta cctctatgtt ttagtcatca tcctctgata tttttactac tatgaatata
     7921 ggaagatgat ctgatatttt atctttcata agtctatatt gtccctgagt aaaatccaag
     7981 gctccacttt tccctgtaaa ttctttagta tatattgtag agagaaacat attatcataa
     8041 gaacttgcca agcttttctt tcccagtgtt gttttaataa ctgggcttaa agcatatatt
     8101 attttatcag gatgggaaag caatttctca aatgattcat caaatccaga taaattaaaa
     8161 tctccagcaa taataacatc attttctttc aaatccagat tttgaaaata atcgtatact
     8221 tcattcattt taaaagcttc cgctctcctt gcactttcat tttttccaaa tactgaatgt
     8281 acaagaacaa atgtaaaatc aaactctcct attttaaaat ctgctccata tggaggtctt
     8341 gcaaattttt cttctgtatc tttatagaat cctctttctt ttaaaaattc tactttatct
     8401 tttttccaca cataagcaaa atattcctta tagctatttt ttcctactgg atatggagaa
     8461 atgtgataat cccatttttc tcctgacacc ttctccagag cattgataag tttttctaca
     8521 ccttctgcat ccattacttc tataagccct gctatatcaa acatctcaag tgcctgtgct
     8581 gtcaatatat agtctttctg acttttcccc agccttagtg tattaaaaga tgctatatat
     8641 ccctcttgag caaaaattgt cattgctaac agaaaatata taaaaactag ttttattttt
     8701 ttcatatttc acacaccttt tttgtaaaaa atactattat gttaatttta ccatatttta
     8761 gtcaataaac aatgagaaaa attgactttt tttcattttt gaactataat ttcttaacat
     8821 ggagaattaa tttcatataa aaaatgaggg gatgatatat atgattgcag cattttttga
     8881 cattgatggg acaatttata gaaattctct tctgactgag cattttaaga aacttataaa
     8941 atatgaattg ctggatttta gagaatatga cacaagagta aaagaagctt tcaagctttg
     9001 ggatgagaga gttggagact atgataaata tctccttgga cttactcaaa cttatgttga
     9061 tgctataaaa gggctctcta caaaatataa tgattttgta gcagatcagg tagtcgagtt
     9121 aaaaggaaac agagtttatt cttatactag aagaatgata aaatggcata aggaacaggg
     9181 acataaagtt attttcatct ctggaagtcc tgatttttta gtgtctagaa tggctaaaaa
     9241 atggaaagct gatgatttct gcggttctgt ataccatata aaagatggag ttctttctgg
     9301 aaaaatttca cctatgtggg attcagaaaa taaaatgaaa tctatacata tgttctgcca
     9361 gaaatatggc attgatttga tgaaaagtta tgcttatgga gatactcatg gagattacag
     9421 tatgcttctc agtgtcggac acccaagagc tattaatccc agccttgaac ttctaaacag
     9481 tataagggaa tctgattatc tcaaaaaaaa tacagaaata atcatagaac ggaaagatat
     9541 tatttataaa gttcactctg atgtagaaac tttataattt ttaggtttac aaaggaggca
     9601 aatatgacag tgagattatt ttattttata atttcattta tgtttatgtt ttttacttct
     9661 aattttgata ttcaggaaaa gcattctgcc tttaaagatt tacctcaaaa cattcttctt
     9721 ttaggtaaaa tagagagcag tcgagaatat agcttcataa aaatagacaa aatagaactt
     9781 gcagacagga caaatttaaa aaatcctata cctgcatttt tagaaatgac agagattgtt
     9841 acagaagagc cttgcataaa tactgttatt tatccacaaa aagatagttt aacattttat
     9901 acaatccttg aacggtatgg ttcccgaatt cttttgattt aacaatctct cataaaaatc
     9961 acattatatt taaatgaaac aataataagg agattaattt atgagagaat ttcatatagg
    10021 aatggatgtt ggttctacta ctataaaaat agtctgtctt gatgaaaagg ataatattat
    10081 ttactcaatt tatcaaagac acctttcaaa tgttagagaa acaacaaaga aaatgtttga
    10141 tgaattttta gaacatatta aaagtaattt tggtgaagat ataagataca gaataagtat
    10201 cactggttcc agtggaatgg gaatatcttc atggattgga atagattttg ttcaagaagt
    10261 tattgcctgt atcaaatcta tcgaaacact tataccagaa actgatgtag ctatagaatt
    10321 aggtggagaa gatgcaaaaa taactttcct taaaaatgat atggatcaaa gaatgaatgg
    10381 aagctgtgct ggtggtacag gagcattcat tgatcaaata gctactcttt tagatacaga
    10441 tgcttcaggt cttaatgaac ttgctaaggg attcgattct atctatccta ttgctgcaag
    10501 atgtggagta tttgcaaaaa ctgacataca gcctcttatc aatgaagggg taaaaaaaga
    10561 aaatatagct gtatctgtac ttcaggctgt agtcaaccaa actataacag gtcttgcctg
    10621 tggtaaaaaa ataactggaa aagtagcttt tttaggaggg cctcttttct ttttaagtga
    10681 gcttagaaat agatttatcg acactttgaa acttactcct gaagatgtcg ttttccctga
    10741 aaattcacag ctttttgttg ctcagggagc tgctttcctt gctaaagaaa atgaatctgt
    10801 attttcatat gatgaactta aaacaaaaat agaacgtctt aatgaaaaag atacttctga
    10861 tacttcaagg ttgcagccat tatttgaaaa cgaagatgca cttaatgaat ttcttgaaag
    10921 acatgaaaaa gaaaaaatag aaacaagaga tttaagtact tatgaaggaa atgcttattt
    10981 aggaatagat gcaggttcta ctactattaa agtggttctt atttcagaag aaaaagagat
    11041 attattctct cactattctc ataataaagg aaatccactt gataatatta ttgctacact
    11101 taagaatttg tattcaaaga tgtctgaaaa agttattatc aaaggttcat gtgttactgg
    11161 atatggagaa agccttatta aagcagcact gagagttgat attggtatag ttgaaactat
    11221 ggctcattac aaaggatctc aattcttcca gccaaatgtt gattttatac ttgatattgg
    11281 tggacaggac atgaaatgtc tgaaaataca ggatggtatt ataacttcca ttcttttaaa
    11341 tgaagcttgt tcttcagggt gtggatcatt ccttgaaaca tttgctcatt cacttggaat
    11401 ggatatttta gaattttcaa gattgggaat ggaatctaaa tctcctgctg accttggtac
    11461 cagatgtact gtatttatga actcaaaagt taaacaggct caaaaagatg gagtagaagt
    11521 ctcagatatc tctgctggac tttcttattc tgttgtaaaa aatactcttt ttaaagttat
    11581 aaaaataaaa aataaagatg aattaggtaa aaatatagtt gtacaaggtg gaactttcct
    11641 taacaattct gtactaagag cttttgaatt agtttcagaa agaaatgtaa tcagacctaa
    11701 tgttgctgga cttatgggag cttttggagc tgcccttata gccatggagc aagctgaaga
    11761 aagttcaact attatgactc ttgatgagct taataatttc aactgtacta caaatcttac
    11821 tagatgtaaa ctttgtaata atcattgtct gctgactatt cataagttca aaaatggaga
    11881 aactttcatc tctggtaaca gatgcgacaa tccacttgga aaaatgaaga aaaatacagc
    11941 tcctaatatg tttgattata agtacaacag attatttaat tacacacctt tagagccttc
    12001 aaaagctaca agaggagaaa ttggtgttcc tagagtattg aatttttacg attcatatcc
    12061 attctggttt acattattga ctcatcttgg atttagggta attatatctg atgactcatc
    12121 taaaaaatta tacgaaaaag gaatagacac aatatcttct gattctatat gctatcctgc
    12181 aaaacttgtt catggacata ttgtagatct tatagaaaaa ggggtaaaaa gaatattcta
    12241 tccttgtgtt atatttgagg aaaaagagga tataaaatct tctaatcagt ttaactgtcc
    12301 aattgttatg tcttatccag aagttattaa taacaacatg gatatcttaa aagaaaaaca
    12361 tattgatttg atattacctt tcttctcatt tgaaagtaag gaagtacttt acaaaactgt
    12421 atttgaagaa tttgaaagat ttggaataac aaaatccgaa gctaaaatgg ctgtagatgc
    12481 agcatgggaa gaaaaatata atttcagaaa agatatgaga aacaaagctc ttgaaataat
    12541 tgctgattta gaaagaactg gaaaaactgg agtagttctt tgtggaagac cttaccattg
    12601 tgataaagag attcatcatg gtatcccaaa tataataaat tcatttggaa tagctgttct
    12661 tacaggagat gctgttgcca gtctcgcttc tttagatgaa gagcttagag taatagatca
    12721 gtggacatat cattcaagat tgtacagagc tgctgcctat gttggaaaaa gcagctgtct
    12781 tgaacttatt gaattaaata gtttcagctg tggtatagat gctgtaacta ctgatcaggt
    12841 agaagaaatt ttagctaatc acggaaaagt tcatactctt ctgaaaatag atgaaataag
    12901 caatcttggt tctgtaaaaa taagaataag aagtctttta gctgctcttg attacaagaa
    12961 aaatgctctt agatcttctc ttaaaaagaa aatagaatac aaaaaagccc aatttacaaa
    13021 gaaaatgaaa aaagaataca ctattttagc tccacaaatg gcacctatgc actttaaatt
    13081 attgaaaact gctttcaaag ctgaaggata taatcttgaa gttttagaag agacacagga
    13141 agcattagat tgtggacttc aatatgtcaa caatgatgcc tgctatccat ctatattagt
    13201 tattggagaa cttattgcag cacttaaatc aggaaaatac gaccttgata aaactgctgt
    13261 tatgatctct caaactggtg gaagctgtcg tgctaccaac tatgttggat ttttgaaaaa
    13321 agctattaga gacagcggct ttgaaaaaat accaatttta tctttaaatg caagcggttt
    13381 tgaaaaacag gaaggtttct ctatcactct tccttttgct cataaatgtc tgatagctgt
    13441 atcatatgga gatattctta tgaagcttct ctatcatgta cgtccttatg aaaaaatcaa
    13501 aggaagtgct ttggaattat atgaaaaatg gaatgaaaaa gttaaagaaa acatagcaaa
    13561 tggtaaattt tctcaattta aaagtaatat aaatgcaata gtagaagatt tttctaagat
    13621 tgaagtctct gatgaaaaga aaataaaagt aggaatagtt ggagaaattc ttgttaagtt
    13681 cagtcctttt gccaataata atttagctga cttcattgaa gctgaaggtg gagaagtata
    13741 tacttcaagt cttatgagct ttgtaaaata ttgtatatat agtgatatat ttattacaga
    13801 aagattcaaa ggtaaaattg cagcaatgaa acttaaagct gccctttggg taatagacca
    13861 gtatacaaaa gtattaaata atgctttaca aaagaatcct agatttggtc atgaagattc
    13921 tattcaagac cttgctaaaa aaacttctca atatatctca ataggaaatc aatctggaga
    13981 aggatggttt cttatgggag aaatgataga attcattgaa aaagatgttc ctaatatagt
    14041 ttgtgttcaa ccttttggat gtcttccaaa tcatataaca ggaaaaggta tgattaagaa
    14101 gttgagatca gaatattcta atgtcaatat agctcctata gattatgacc ctgcttattc
    14161 tgaagttaat caattaaata ggataaaact tatgctgtct gttgccagaa aaaacctaaa
    14221 aaattcttaa aaaatattta atttgtgata taattaaaga aataaagagg ttttaatttt
    14281 ttggaggtgg attgattgta taaagctaat tatcttatga tgactcctgg acctacaatg
    14341 gtaagagaaa atgtgttgaa agctagatgc agcttttttg gaaatcctga tctagaccct
    14401 aattttttcg ctttttatga agaactatgt aaaaaaactg gaaaattatt tggtgctaaa
    14461 aaagctcaaa ctataataat gaatggggaa ggtatgctgg ggttagatac tgcatgtgct
    14521 tcacttactg agcctggaga taaagtttta gttatatcaa atggtatttt tggagaggga
    14581 tttaaaggac ttgtagaaac ttatggtgga gaagtcactc tttttgaaac tgatgtaaaa
    14641 aaagctcttg atattgacaa attaagaata ttccttgaaa aaaacaaaga ttttaaatat
    14701 gctactatgg ttcattgtga tactccatct ggagtactca acaatgtgga agttatttgc
    14761 aaaatcttaa aatctgaagg aattatgaca gtagttgata gtgttgctgc tgtaggtgga
    14821 gtacaattag aagtagatga atggggaatt gatattgccc ttggaggttc tcaaaaagtt
    14881 ttctctgctc cttctggaat tacaattatg acagtaagca atgatgcatg ggaagctatt
    14941 gaaaatagaa aaactccaat tgcttctttc tattgtaatt tatctctatg gaaaaattct
    15001 gtaaaagaac agcttttccc ttatacaatg cctgccagtg atctaatggc gtttgacgtt
    15061 gctattgata atatttataa agaaggagta gaaaaagtca gagaaagaca ctatactgct
    15121 gctgaatatg taagaacaag acttatggat atgggagttg acctttatct gaaaaatgga
    15181 tactctccaa cagtgactgc tttctgtctt ccagaaggat ataactgtaa ggaagtttct
    15241 gattatcttc tgcataattt tgaagtaatg attgctgatt cttattctta cttaagcaac
    15301 aaagtcctta gaataggaca tatgggtgaa aatgctcgtt tttacagact tgactatact
    15361 ttaaaagcta ttgaaaaaac tttaagagtt ctaaaaaaat aatgttttac attaaaagtc
    15421 tcttttatga cacttcaagt cctaaaagag actttttaag tccaaactat tgtttttatt
    15481 ttattttaga gatattatat aatgctacta ttataaataa tttcaaattc aaggggaagg
    15541 agaatttatg tgtgattttg ataaaaacaa taagatgcca ttatatgggc aattgatgaa
    15601 ctttttactt tcagaaatag aatgtgacaa atttaaggag catgaaaaaa ttccttctga
    15661 aagagatcta tgcgataaat ttaatttaag ccgtgatact gtaagacagg ctatttttca
    15721 gttggaaaaa atgggttata tctataaaaa acatggaaaa ggaacttttg tagcccaaaa
    15781 gcaattaaaa cctgatctat acaaatttta tgattttaca gaagaaatga aaaaacttgg
    15841 aaaggaagct gtttctaaag ttttatcttt tgaaataatt cctgctgata aatatatatc
    15901 gaaagctttg aagataaaag aaaacagtaa tgttcacaga attactcgtt taagacttgt
    15961 agattctatt cctcttattt ttgaaaaagc atatctgtct acagaaaaat ttgacttctt
    16021 ttctatagat gaattaagca attcatctct ttgcaacata ttgaaaaata gattttctgt
    16081 aaagttttct aaaggagagg aaacttttta tcctattact cctgatgatg aaataacaag
    16141 atatttgaat ttaatgaaat ttcagccagt tataaaaata gagagaacta cttttgaaga
    16201 tgaaattcct gttatgttta ctgaaagaat aattagagga gataagttta aatatacaat
    16261 tactacttcg ttctaatttt taaagaaaac taaatttata gaaattcttt ataataaata
    16321 gatataaatg tttatctgct tgttataaag gatttctttt tttctttcta aaaaaactat
    16381 actaaaaaac tatattttat gatataatag aatgtaacat ataaaaatga taaaggagtt
    16441 gaaaatgaaa ataactcagg aaacaaattg cgctataaag actattttat atctatctac
    16501 acttcaaaaa ggtgaaatct ctcctgcaaa aactattgga aaatccattg gtttttctga
    16561 taaatttgta cttaaagttt taagaccttt aaccagtgca aatatagttc ttcctttcag
    16621 aggtgttact ggaggttatt gtttaggaaa aactactgat aaaattactc tttttgatgt
    16681 tatagttgca gtacaaaatg atattaatat cttaacagtt atgaaaaata tgtctaaaaa
    16741 agatataaaa aaagatgaaa tattttctat atttgatcaa atacaggaat tagaaaaaaa
    16801 gattttgaaa aaaattactt ttgatatgat tataaataac aaagttaatc taaaaaatat
    16861 attagaagat actctttaat aatataaaag ctgcctgcaa ggatatcctt atcttcaggc
    16921 agctgctatt ttcttttctg attatctaaa ttgttcagaa ccattagaat aatggcactc
    16981 ttttactaat ttaccttctg cgtcatactc tttgtaaaca ccatctaatt ttccattgtc
    17041 tccatagttg cattctatat ataaaacacc atttgaaaaa tactctttgt aagaaccata
    17101 catagctcca tttttaaaat taacatcaag tttcacttgt ccattcggga aatactttac
    17161 attttttgtt gttgttgagt tgctgacatg ttctgacgat ttttttaatt ttccatttgg
    17221 aaaaaattct tcataaagtc caactgtctc tccatttact agagtacgtc tagaacttaa
    17281 ttttccatca ctatagaaag tttcatatac tccatggata tttccatctt tatagaattt
    17341 atgagtttct acctgaccat tcatataata tgatttatat tctccttctc taattccatt
    17401 tacataattt ttttcttctt gaattctccc attatcgtaa gtttttaccc atagtccttc
    17461 tttttttcca tctttattat actgatttgt catgattatt ccccctttga ataatgataa
    17521 tgatgtatag ttaatattag tatacctcat aatctttaag aaataaagag attaaattaa
    17581 atttttccta ttttaatata tttttttctg ttttataatg gaaaatatga atatttaaca
    17641 tattaaagtc aaaaaatagt tttttaccaa atgaaatgtt tttaattaca tctgttgaag
    17701 cccttgctgt aaactccttt tctcctattt tgaaatatat atatacttca tttcccatgt
    17761 tttcaacaac acttactaca ccctgggctc tatttttttc ctgactgttt tcatctgaaa
    17821 cttttatatt ttctggtctt attccaaacc agattttttc tccaatatta ttttttgctt
    17881 tttcagcttt ttctttatcc aaaattaaat aggtatcagt atccagcttt actagaactt
    17941 ctccattttt ttccagaagt tctccttcaa ctatgttcat agctggtgac ccgataaacc
    18001 ctgctacaaa tttatttaca ggaaaattgt atatgttcat aggcgtatct acctgcataa
    18061 cttttccctt attgagtaca catattctat ctcccatagt cattgcttct acctgatcat
    18121 gagttacata tatcatcata gtttcttttc cttcactgag aagttcctta tggagctgtg
    18181 ttatccttac tctcatagac actcttaact tagcatccag attagaaaga ggttcatcaa
    18241 aaagaaatac tttaggctct cttactatgg ctcttcctaa ggccactctc tgcttctgtc
    18301 cacctgacat ctctttaggc tttctatcta aaatatcgct tatttccaat ctttcagcag
    18361 tttccctcac tcttttatct atctcttttt taggaaattt tgccattttc aatccaaagg
    18421 ccatattttc ataagtagtc atatgaggat aaagagcata gttttgaaat accatggcta
    18481 tacctctgtc tttaggagga agcttattgg ctagttttcc ctctatccat aattctccct
    18541 ctgttatttc ctccagtcca gctatcattc taagcatagt tgacttggca cagccagaag
    18601 gacctacaag caccataaat tctcccggct ttatctctaa atctattcca tgaacagcct
    18661 taaagccgtt tggatatact ttttcaatat tttttaaaat aactccgctc atatctgctc
    18721 ctttttctgt attcttcaat aagaattata ccatattttt cccctattgc ataaagacaa
    18781 aagctcaatc ttatattttt cctctattga caataatttt tgaatatgat acaattcatg
    18841 aaataattaa gtccatagag agagatggag ggacaggccc tttgatatct cagcaacctg
    18901 ctttaaatgt aagcgtggtg ctaattcctg atagatggtt tagattctag aaattttaag
    18961 cttttttcat ctatcaggtg gaaaaagctt tttttattgg attcaaacag gagatgagca
    19021 gatgaaaatt tcagaattat ttaaaaacaa aaaaacagtt gtatcctttg aagtatttcc
    19081 accaaacact atatattctt tagaggatgt ttattcttcc attgatgagc tggcaaaatt
    19141 acagcctgac ttcatgagcg tcacatatgg agctggggga gcaactagag gaagaacagt
    19201 agagattgca tcaaagatta agaatgataa taaaatagaa gctctggcac acctcacttg
    19261 tcttggagct aaggcaaatg aaattgatga tatattagaa cagttaagaa aaaataatat
    19321 agaaaatatt cttgctttga ggggagacaa gcctaaagat ggacttcctg ttgaagaggg
    19381 ggattttaaa tatgcacagg atcttatttc ttatgtaaag ggaagaaagg atttttcaat
    19441 aggaggggca tattatcctg aggggcatca ggagacaaat gatcttctgg atctctttaa
    19501 cttaaaaaca aaagtagatt ctggaactga ttttcttatc tctcaaatat tctttgataa
    19561 cgaatctttc tatcgtttca gagataaagt ggataagctt caaataaatg ttccattagt
    19621 tgctggaata atgcctgttg ctaatgcaaa gcagatcaga aaaataactt caatgtgtgg
    19681 atgcagcatc cctgaaaaat ttcaaaaaat attaaacaga tatgaggata atcctaaagc
    19741 attgaaagag gctggaactg catatgcaac agagcagatt atagatttaa taacttccga
    19801 cattgatgga atacacctgt atactatgaa taaagtagat acagctaaaa aaataatggc
    19861 aaatatagca catataagag aaatttctgg aggtagcaga taatgataaa tgaactgaaa
    19921 aaaagagtac ttgtattaga tggagctact ggaacagcta tccaaaaata taatcttact
    19981 gatgaagatt ttcaaggtaa aaaaggctgc aatgaaatcc tgaatataac aagacctgat
    20041 gtaataaaag agatacacac taagtatatt gaagctggtg ctgacattat agaaacaaac
    20101 tcattcaact gcaacagaat atctctgaaa gattatgaaa tagaagatat gtcttacact
    20161 ctttcaaaaa aaggagctga actggctaga gaaacagcag ataattttta taaaacttct
    20221 gggaagaaaa tatatgttgc tggttctatt ggtcctacaa gcaaaagtct ttctcttcca
    20281 atgggagatg ttccctatga aagagaaatt aactttgatc agatgaaaaa aatctattct
    20341 gagcagatag aaggggtcat agatggcggt gtagattgcc tcttgataga gactatattt
    20401 gatggactaa gtgccaaggc tgcccttgta gctgccgagg aactttttga aaaaaagaat
    20461 atacagcttc caattatgat atctgcaact gtaaacagac agggaaaaat tttctcagga
    20521 cagagcatag aatctttaat tacagctttg gacagacctt caattatttc ctttggtctt
    20581 aactgttctt ttggagcaag ggatcttatt ccaatgataa aaagaatagc ttcttttaca
    20641 gataaatata tttctctcta tcctaatgct ggacttccta atgaagaggg agaatatgag
    20701 gagactcctg agataactgc tggatattta aaagaattag tagatgaaaa aaaggtaaat
    20761 attcttggtg gatgctgtgg aacacatttt tcgcacataa aagcaatagc tgatttagta
    20821 aaagacaaag aacctagact tccagtttcg aaagaaaata gatattttct ctctggaaat
    20881 gaaatatatg atttcagcaa taaattcaca atagttggag aaagaaataa tgtagctggt
    20941 tctaaaattt tcaaaacatt gattgaagaa aaaaactata taaaagcttt agaaatagct
    21001 cgttcacaaa tagaaaaagg agctgctgta ctggatatca accttgatga cgggctgttg
    21061 atacctcatg aggaaatgga aagattttta agaataattc aaaatgatcc catagtctca
    21121 aaaatttcta taatgataga ttcatcagac tttttcacta ttgaaactgc cttaaaaaac
    21181 atagctggaa aatcaatagt aaattccatc tctctaaaag agggagaaga agctttcaga
    21241 aaaaaagcca gaataataaa aaaatatggt gctgctatgg ttgttatggc ttttgatgaa
    21301 aatgggcagg gagtctctta tgaaagaaag gtagaaatct gcaatcgttc atataaaata
    21361 ttggctgaag aaggagttcc cagctcagat atagcttttg atccaaatat actgactata
    21421 ggtactggaa gtgaagatga cagatataat gggctgaatt ttataaaaac agttcaatgg
    21481 ataaaagaaa atcttcctca atgcagtatc actggaggac ttagcaattt atcctttgcc
    21541 ttcagaggaa acaatccttt gagagcagct atacactctt tgtttattga aaatgcaaaa
    21601 gaaaaaggaa tgaattttgc tataatgaat cctggtgaga aagctcctca gcttacttca
    21661 gaagaaaaaa atacaatcct atccttaata aacggagaag aggattctct tgattctata
    21721 ttggaacttg ctgtaaaatt aaaaaatgcc tctgatcttc ttaaaaagaa cagctcctct
    21781 gctcctaaaa taataaagaa tgattttgat tctttaaagg acagaataga aaatgctctt
    21841 atttacggag gcagtacaac ttttgataca gatataaata ctgctatgga aactatgaca
    21901 cctttagata ttatacaaaa tattctgatg aaaggtatgg ataaaatagg tgttcttttt
    21961 gaaaagggag aactatacct tccacagctt ataagatcag caagtgttat gaacagagct
    22021 gttgatattt tgaaacctca tatgaaaata gaagccaata taggaataaa aggcaaagtt
    22081 cttatggcta ctgtagatgg agatgttcat gatattggta aaaatattgc tggaacagtt
    22141 ttgaaatgca atggttatga agtgatagac ttaggggtaa tggtaagcaa agaaaaaata
    22201 cttgaagaag ctgtaaaaaa caatgtggat atcattacat taagcggtct tatcagtcct
    22261 tcattaaaag aaatgaaaaa gattctttct cttttagaca tcagcaaact ttctatccct
    22321 gtattaattg caggagcagc tacttctaaa ttgcatactg ctgtaaaatt agagccattt
    22381 tatcaaggaa aaacttttca tactacagat gctttagata ctcttacaat aataaataag
    22441 ttgatttatg gtgacagaga tttatttata actgaaaaaa caaaagaact cagagagtta
    22501 tgcaaagtat atttgaataa taaaaaagac acttctaaaa tatcagtatc tcctaaagaa
    22561 gattttactt cagaagttat agctcctaaa caattaggaa aacaatatat agaatttcct
    22621 ctgcaaaaga ttgaaaaata tattaactgg aattttcttc ttcataatat gaaagtaaaa
    22681 aatacacctt tagaagaaaa tacactaaat gatgctaagt atattttaga aaaaatgaaa
    22741 gaaaatgata taaaggtcaa atgtgctttt ggaattttcc cttgcacaaa agattctgat
    22801 aatttaacaa taaaagatag tgataaaaat tggtctatct cttttataag aggggaagta
    22861 aaaaataatg atattggaat aagtgatttt ttcaatgaaa atgactttat agggactttt
    22921 attatttcag taaacagctc tctatttgat gaagacaact atatgagcat aatggaaagc
    22981 attcttctta caagaattgc tgaagctgct tctgaattta tggaaaatta tttgaaagaa
    23041 gaaaatatct ggctgcctaa tatcagacct gctataggtt attcatctat tccagatcat
    23101 tctatcaaga aaactatttt cgaaatcact gaaggtgaaa gaacaggagc atatcttact
    23161 aataattttg ctatgtctcc actgagtact gtatgtggta tttatatttc caatccaaag
    23221 agtttttatt ttgatttgaa ataattttaa atacctgata cagtatattt atactaagaa
    23281 aattaaggag gcaatattat gatagttgta tatgcaaaat ctattgtacc tgaaaaaaat
    23341 attgataaat atttagagat agcaaaaaaa ttagcagagg aaacaagaaa agaaaaagga
    23401 aatatttttt atgaaatggt acaggacaaa aataacagaa gtgttcttgc ttttatagag
    23461 aaatgggaaa atatggaagt tttagataaa catatgaaaa ctccacattt cactacattt
    23521 gttcctcaat taaatgaatt aagagaagga gaatctgaac tcgctataca tgaagttcta
    23581 ttctaaaaaa aattggcagc ctgtataaaa cagactgcct ttttatttat taatctctgc
    23641 atattccttg ttcttttgct actttttcaa ctgctgctgc tactgcatct gcaactcttt
    23701 tatcaaaagc atctggaatg atgtaatttt cattcatttc ttcatcagta ataagagaag
    23761 ctaatcctct tgctgctgca agtttcattt cttcagttat ttttctagat tttgctctta
    23821 aagccccttt gaataatcct gggaatacaa gaacgttatt tatttggtta ggatagtctg
    23881 atcttccagt tcctactatt tttgctcctc ctgctaaagc atcttctggc attatttcag
    23941 gagtaggatt tgccattgca aatattacag catctttatt cattgttttt accatttcag
    24001 tagtaagaat atttcctaca gatactccaa caaaaacgtc ggctccttgt actgcaaatg
    24061 ctaaatctcc agcaagatca ttagggttag ttatttcagc taactctctc ttagagaagt
    24121 cataagattc tttatcactt tttctaagga ttccaggttt atcaagaact aatatttctt
    24181 ttgctcctaa atctcttata agtttagtta tagaacttcc tgctgcccct
//
