LOCUS       NC_014376.1            25419 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_014376.1 [Clostridium] saccharolyticum WM1, complete sequence.
ACCESSION   NC_014376
VERSION     NC_014376.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 00:47:57
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1415462
            Orig. end    :: 1440881
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..25419
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[1425462:1430881]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..15419
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..25419
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..25419
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="succinate2propionate"
                     /region_number="5"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             151..765
                     /locus_tag="ctg1_1306"
                     /transl_table=11
                     /translation="MEKIVDARGLACPQPVIKAKEALKGMGEGTLKVLVDNEIAVQNVM
                     KLGNFEGLAPVSEKKGEKEFEILFHVSGTSGQVKETVLEEECIPDTRKKGLVAVLSSDQ
                     MGGGNEELGRILMKGFVYALTQLEELPETVLLYNGGARLSVEGSQSLEDLKSLEAQGVE
                     ILTCGTCLNYYGMSDQLRVGAVTNMYEIAEKMAGARLVMRP"
     CDS             complement(983..1546)
                     /locus_tag="ctg1_1307"
                     /transl_table=11
                     /translation="MSLLTITAYFIIPIYTILFAWGTDWFNVNFSVLGNLADRKNLFLL
                     WGVIVGTYFYYVLKQIIGGLPRNKKETLVSTSALLLLALAVVTPYLPDSQPIHAVLHVV
                     LSFLASISLLVCLYMIIWKLYCMNQEVYRPYLHCLLMITAVSAFLFFLTGIVSTVLEIF
                     FTLSCTIMLQKLYRRNRVPKILWR"
     CDS             1653..3053
                     /locus_tag="ctg1_1308"
                     /transl_table=11
                     /translation="MIQLPDGFREKMKGLLEEEYDSFMESYHKERVQGLRINPLKISRE
                     NFMEICPFQLKKIPWAEEGYYYPADERPGKHPYHEAGLYYIQEPSAMAVVELLDPRPGE
                     RILDLCAAPGGKTTHIAGRLKGNGFLLSNEIHPARARILSQNVERLGIGNCVVSNEDSQ
                     SLSRRFPSFFDRIVVDAPCSGEGMFRKDETARQEWTPGHVTVCAARQEEILSNAAVMLK
                     PGGTMVYSTCTFSPEENEQVIEAFLFSHPDFSIKDEGKRPGLSPGRPEWSRTGLGDLKK
                     TFRIWPDRSEGEGHFLAVLKKSGEHMSEKKKTMPEYTRDKTVLTELAGFLKDFLVDPAP
                     LMSRKEFILFGDQLYLLPPEMIDFKGMKIIRPGLHIGTVKKNRFEPSHGFALSLKKEEV
                     KCWIDLPPDGEEIVRYLKGETLPQDAAFSRDNKKGWILVNTGGYSIGFSKLAGGILKNH
                     YPKGLRWM"
     CDS             complement(3016..3939)
                     /locus_tag="ctg1_1309"
                     /transl_table=11
                     /translation="MKLTMNYTITQTHEAMTVKQYLLDLGYSQSLIRQLRSRSNGIVVG
                     GEPVSSTRILKPGDHLSVFICEDESSENIVPTPMPLQIEYEDEHILVVNKEAGVPIHPS
                     QGNFDHTLANGMAYYFMKRGESFVYRAINRLDRDTTGLLVLAKNPLSACILSDMVQKRE
                     IRRRYLAITCGKPPLEGTIDAPIARVDGSTIERCVDFIRGEKARTHYKRLYYDPVTGQS
                     LVGLCLETGRTHQIRVHLKSIGYPLPGDFLYHPDYRYISRQALHSFRLDFLHPIKKEPL
                     SFEAPLPKDMQYIGVTSTEGLWDNDF"
     CDS             4028..4297
                     /locus_tag="ctg1_1310"
                     /transl_table=11
                     /translation="MFDQDTYEALEMEFEKNHILEDVEEVLLDFAEALADKGLMDKELV
                     LTESYGKIPIQVSGICSEEEGDVNVLIKRLRIGKREFEIDDYFL"
     CDS             4336..5214
                     /locus_tag="ctg1_1311"
                     /transl_table=11
                     /translation="MMTIRQEYSPKELGVDLLCDLAGAFLFNIGIYNFAVNAEFAPVGV
                     SGIALILRYLFGLPMGITSMVLNIPIVLVSYRLLGRRFLLRSMKSMIIFALVLDYVVPY
                     LPVYQGNPLYASACTGIFSGLGLTIVYLRNCSTGGTDFLVMAIRKLLPHRTIGQISLVV
                     DAIVIIAGGFVFRNLDAVILGLVSSIVTTMVIDKIMYGLGAGKLVFVVTSRESEVAQRI
                     EENTGRGCTFLKGQGSYSLDEKKVVMCACNNSQVVPIRRAIHEIDKEAFIIITDSNEVY
                     GEGFKAIGGQL"
     CDS             complement(5260..6504)
                     /locus_tag="ctg1_1312"
                     /transl_table=11
                     /translation="MATEPLIFHIDVNSAYLSWESVRRLEEDSSALDLRTIPSAVGGDA
                     SLRHGIVLAKSTPAKAFGISTGESISQALRKCPSLTVVPARFDVYLKKSEQLMEILSDY
                     TPDMEKFSIDEAFLDMSSTIHLFGPPLVAANRIRERIWRELGFTVNIGVAPNKLLAKMA
                     SDFKKPNLCHTLFTHEISSKMWPLPIGDLFFVGHSARKKLEGIGIHTIGELASCSISHL
                     KPLLGEKYALLIHDYAWGIDSSPVAERESFNKGYGNSTTLSHDIDDFDVACQVLLSLSE
                     TVGARLRTDHVMSDCICVEIKDWNFQTRSHQITLNNPTDSTAVIYENACKLLKELWDRT
                     PLRLIGVRTTKISEEGYFQLNLFESEHTRKMKEMEKAVDRIRSKFGTDSVKRASFLKKD
                     AIVDHTAGRGKSGIK"
     CDS             6632..7951
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S11"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_1313"
                     /sec_met_domain="Peptidase_S11 (E-value: 5.7e-48, bitscore:
                     161.4, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRHAIGMLLTAVFVLLLVTGTAGIRLAGKEAVNEKTTVTEEKGEK
                     SGSVQTKDELNLYAQSAVLMDASTGRILYGKNEDIARPMASTTKIMTCILALEYGNLSD
                     TVTASQNASSQPKVHLGVYKGETFLLKDLLYSLMLESHNDAAMMIAEHIGGSQEGFAGL
                     MNQKARDLGCTDTYFITPNGLDAREEKDGQVKEHSTTAADLARIMNYCIGQSPKKKEFL
                     EITGTKSYSFTDLEGKRSYSCNNHNTLLAMMNGAFSGKTGFTGGAGYSYVGAAQDNGRI
                     YTIALLGCGWPPHKAYKWSDARKLFQYGMERFHYRNVYKDLSLPDIPVKEGIPASGRLD
                     EPVTVSCIIGGEEEKDLTLLLADEEEVTVQTEIPKELIAPVRKGQAVGNVIYRLNGEVI
                     KSYTVCLNQGADRLTRAWCIKNIVSKYISMPGVKGILSGF"
     CDS             8175..9020
                     /locus_tag="ctg1_1314"
                     /transl_table=11
                     /translation="MNMRKIATVLAGNTIYALAVSLFILPGGLITGGTTGLALVAYHQL
                     GIPVSVFVGGFNLLMFAAGAMVLGKQFAFTTMISTFYYPFILGVFENLFGQAAMTGDRM
                     LATVFSGLFIGVGIGMVIRAGASTGGMDIPPLILNKKWNLSVSMTMSVFDCLILLSQMI
                     FSNKEQILYGILLVLTYSMVLDKVLLIGRNQMQVKIISEKYEEINQAIQTRMDRGTTLL
                     ASEGGYLRTASFTVLTVISGRQVSRLNELVMGIDPNAFMIINQVNEVRGRGFTLHKEYK
                     "
     CDS             9156..9734
                     /locus_tag="ctg1_1315"
                     /transl_table=11
                     /translation="MLRKKIGLFCFAAVFVVALAAGCARKEAGDLGGSLPEAAQSETAA
                     VRMEKARIEEEADDEAAVKEDMDQSGPGTEATEEVESTGPGKKVEAFAEKIQEAVGDRD
                     LQAFGDLLFYPCVLLTGDEETITLKSREDLLKQNPDMVFGDDLMIAVANVDTVSLKKTD
                     QGVVMGEGDSRITFQERSDGSYGITEIRE"
     CDS             10001..11455
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1316"
                     /sec_met_domain="CT_Vparvula (E-value: 5.6e-143, bitscore:
                     475.1, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNSTETSASDRIHALLDENSFVEVGGYVTARSTDFNMTAKETPA
                     DGVVTGYGTVEGCLVYVYSQDASVLGGSVGEMHARKITKLYAMAMKTGAPVIGLVDCAG
                     LRLQEATDSLNGFGEIYMSQTLASGVIPQITAIFGTCGGGMAVSAAMADFTLMETRGGK
                     LFVNSPNAIEGNYTGKCNTASADYQSRETGLVDFTGDEDDILNKIRTLISILPSNSEDD
                     MSYDECSDDLNRVCSDLENYVGDTAVALAQISDNQFFMETRKEYAASMVTGFIRLNGMT
                     VGCVANRTESYNESGLKTAEYDALLSGQGCEKAARFINFCDAFSIPVLTLVNVKGYEAT
                     PCSEKRIARAAAGLTYAFANATVPKVTVILGQALGTAYLTMNSKSIGADVVYAWPSATI
                     GMMEPSEAVKIMYADEISKAEDGKALINDKAESYRSLQSSALSAAKRGYVDDIIDAGET
                     RARVIAAFEMLFTKREDRPAKKHGTI"
     CDS             11473..12243
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1317"
                     /sec_met_domain="OAD_gamma (E-value: 1.5e-22, bitscore:
                     77.9, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLNMKRVALGLIMAVCLFSLSACSKADTGSQEIDAGVQTQMEKL
                     PGSFLELYAGLEDSQVAEFKKNMLSQDQYAALAEGVDSWENVKDDLGALVSIGDTVKVE
                     AIDHGYSATVDAAFEKRNLEFSITTDLKLTKITGVAFVPEYTLGERMEKAVFNTLMGMG
                     TVFLVLIFISLLIGGFQYIGKFESKMKGKAQEPALQPIPAAPVPVAEEAEELVDDLELV
                     AVITAAIAASTGGSPQGLVVRSIKRAPVSKWKKA"
     CDS             12265..12660
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.8; E-value:
                     3.7e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1318"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.5e-19, bitscore:
                     66.8, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNYTITVNGNVYEVTVEEGSSLSAPAAGKKPSAPVPAAAPAPAA
                     APAAAPMKAASAGTEGSVKVAAPMPGKILGVKTSAGQAVKKGDVLVVLEAMKMENEIVA
                     PSDGTVAGVNVAVGDSVEAGATLATLN"
     CDS             12716..13864
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1319"
                     /sec_met_domain="OAD_beta (E-value: 5e-156, bitscore:
                     517.0, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYIGNTFNNLLQQTAFFNLTAGNMIMILVAFVFLYLAIRKGFEP
                     LLLVPISFGMLLVNIYPDIMKETGADGSGGGLLQYFFKLDEWGILPPLIFMGVGAMTDF
                     GPLIANPKSFLLGAAAQFGIYSAYFLAIFMGFNDKAAAAISIIGGADGPTSIFLAGKLG
                     MTALMGPIAVAAYSYMALVPIIQPPIMKLLTTEKERKIKMEQLRPVSRLERILFPIIVT
                     TVVCMILPTTAPLVGMLMLGNLFKESGVVKQLTETAGNAMMYIVVILLGTSVGATTSAE
                     AFLNLNTIKIVVLGLVAFSIGTAAGVLFGKLMCKVTGGKVNPLIGSAGVSAVPMSARVS
                     QKVGAEADPSNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGVR"
     CDS             14007..15419
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1320"
                     /sec_met_domain="HMGL-like (E-value: 1.8e-41, bitscore:
                     140.4, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 1.3e-52, bitscore:
                     176.4, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEIEKKPVKIVETVLRDAHQSLLATRMTTEQMLPVVEKMDRVGY
                     HAVECWGGATFDACLRFLKEDPWIRLRKLRDGFKNTKLQMLFRGQNILGYNHYADDVVE
                     YFVQKSLANGVDIIRIFDCFNDLRNLQTAVTACNREKGHAQVALCYTLGEAYTLDYWKD
                     IAKRIEDMGADSIGIKDMAGLLTPYKADELVRALKESTTLPIDMHTHYTSGVASMTYLK
                     GVEAGCDIIDTAMSPLALGTSQPATEVMVETFRGTPYDTGFDQNLLAEICAYFQPIREE
                     ALKSGRLNPKVLGVDIKTLQYQVPGGMLSNLVSQLKEAGQEDRYMDVLQEIPRVRKEFG
                     EPPLVTPSSQIVGTQAVLNVISGERYKIVTKETKKIFLGEFGQTVKPFDAEVQKKIIGD
                     ETPITCRPADLIAPQLPQFEKECAQWKQQDEDVLSYALFPGVAKEFFEYRAAQQTGVDS
                     SMADKENKVYPV"
     CDS             15780..18122
                     /locus_tag="ctg1_1321"
                     /transl_table=11
                     /translation="MKKYRKARKMAIILASVLVMDSYTGVISPYINTYAYTEKAATVNA
                     TSLNVRSGPGTTYSVVTKLTNGASVTVIDEKNASDGALWYQIRVSGSGGQKVTGYVSKS
                     FLRFPASYTNDADFESRLTAEGFPESYKVRLRALHAQYPKWVFRAQHTNLDWNTAVKEE
                     SLAGKTLVHTNSLSSWKSTIDGAYNWDTSTWIGYDGSSWVTASADIVKYYMDPRNFLDE
                     TNVFQFMTHTYDSSKHTADGLKTMVKGTFLSGESSGGSGGNGSTPGNTDSSGGGTVIGP
                     GAAIGPGASVSPSTGAAQDSGSGKASLEGPQASITPKNLPVLMEYGPGASLSGPSSSNS
                     SGTVTGSSAYVNMIMNAAAQSGVNPYVLAAMIIQEQGSSGAGKSISGKEPGYEGYYNFF
                     NIEAYQSGSMTAVQRGLWWASQSGNYERPWNSPEKSILGGAFYYGNNYVKVGQDTFYLK
                     KFNVQGSNLYKHQYMTNVQGAASEGAVYSKAYNSDMKQTELEFKIPVYNNMPDNPCSQP
                     TGDGNPNNKLSGLSVEGFAMTPTFSRDTLEYNLIVDPGVSSINLYATPLSSLASVNGTG
                     TITLSNGNNDIKVAVTAQNGSVREYVLHVVRQSNGPTYSSGVGASPGGNASSGQGSSSS
                     GGNPSSGPGSSSGPGVSKPSGTDNAGTPGGSNVTIAPNGSANISVQTSTGVISQGPGTD
                     IKVTEAALGSPQQTQASAAAGQSSAYAKGDINGDGKINSLDTLKLQRYLLGLETIPEKG
                     MLSADFNGDGKVNSQDLLLLQKKILGL"
     CDS             18244..20106
                     /locus_tag="ctg1_1322"
                     /transl_table=11
                     /translation="MNRKLKKLTAGLMLACVIAIAGPAGRLVSWAADAKIAFSDPSVMV
                     GNEVTVSMKVTSDSPLGTAEIMLAYDPNVLEFVSGTNANGGAGAIKVLGTMDSANQKAF
                     SFTLKFKALQAGNTQISVTSQEIYDVDSQALSLSKQGSSSVKVTSPATYSKDATLKSLK
                     ISPGTLTPGFSPTVDSYGAEVDANTTDLVVNAVAANAGAHVSLQGEKGLKAGTNQVVVK
                     VTAEDGQTIKNYTIQVKKAEGGETVPATGGSTEPSEAEFGAATVTMNGTEYSIATSFDE
                     ASLPEGFEAGTYSYKGTEVMSGKGLEKDLLLLYLKDSGGNGGFYIYNEGSDSWSQFVQV
                     ETIAKAIVILPLDGDAALPDGFRERQADIDGVRVTGWVENSEAEPQYCLFYAMNWNGEK
                     HFYRYDLTEKTIQRYYASGVSNEEYVKMVNTYNQLTKDYRIQFYILIAVSVMALGLLVA
                     VIILVRKGGRSDPGRSGRDSMGKGKTEKAADGRMWAETEEEIPASKIKRYTREEFDREN
                     SKSEGFRADGPASPISPEYQEESMDMPVDMAEGEQENPEEDDFILESSLEDLERNLALS
                     QERHPVRTNGKSGQRPLGKERGRFQEVEESGEDEDDFEFLDLDD"
     CDS             20455..20877
                     /locus_tag="ctg1_1323"
                     /transl_table=11
                     /translation="MCITDITKDGENMFLQIDFNSDEAIYIQLRNQIIIGIARSNIREG
                     DPLPSVRQMADNIGINMHTVNKAYSVLKQEGFVKLDRRKGAVVSLDVDKIQVLDEMRRD
                     LGVVLARGVCKNVTCEEVHQLVDEIFQSFLKSQMEE"
     CDS             20900..21505
                     /locus_tag="ctg1_1324"
                     /transl_table=11
                     /translation="MLCEKCKIREANIQYTEVVNGIKKEHHFCAQCAKEMDFGVYAAIF
                     DGEFPLGKLLSGLLGIEDKDQGPDKLHQITCPACGTSYEEFVRDSRFGCADCYGIFGPL
                     MEDSLKQLHGNLVHTGKTPVYQKPDYMPLSLGTGENSSQEKDGPGGISSNPNNIGGREE
                     IFQWDARLKEALRFEDYETAAVCRDKIRELKKGYETNA"
     CDS             21498..22529
                     /locus_tag="ctg1_1325"
                     /transl_table=11
                     /translation="MLRWFEQKDTGRPGVISSRIRLVRNWQDYRFPAALDDKESGEMVR
                     KLEFGLKDLGKDEGRIYEFSMLGELEELDRAALRERRILNSAAVSNKKPAGLLVSENED
                     TGIVFNCDDHIRIQLLQMGLHLEELWERANKIDDYINERFAYAFDDRYGYLTSFPTNVG
                     TGLRASVVVHLPMLSQGRKFQGLISDMGRFGASVRGVHGERDENFGSLYEISNQKTLGQ
                     TEREIIDTVSKAAIQLTNQELQVRKLSMQRHREEREDEVYKSYGVLKYARRLTSRDAMI
                     FLSQIMAGLADGLIHTEEDFSVYRLMLGIQPANLQKISDRPLSKEELDGARAEFIRREL
                     PEL"
     CDS             22643..25093
                     /locus_tag="ctg1_1326"
                     /transl_table=11
                     /translation="MIDRFTTKARTAINLAVQAAERLGHGYVGTEHLLIGLLEEGGGVA
                     ARVLEENGVKEDKVLNLISQLIAPDQALRLKEDGGYTPGARRVLENSYREAVRFKANLI
                     GTEHLLISIIRDNDCVASRLLNTIGISIQKLYIDVLSAMGEDAPANKEELMKSPKAKGS
                     TPTLDSYSRDLTELAAQGKLDPVIGRESEIKRLIQILSRRTKNNPCLIGEPGVGKTAVV
                     EGLAQMIAGGDVPETIAGKRLLTLDLSGMVAGSKYRGEFEERIKKVIAEVIDDGEVLLF
                     IDEIHTIIGAGGAEGAIDASNILKPSLARGELQLIGATTIEEYRKYIEKDSALERRFQP
                     VTVEEPSEEAAIGILRGLKGRYEDHHRVTITDDALQAAVKLSSRYINDRFLPDKAIDVI
                     DEASSKVRLTTYVEPAEIKELEAEIELLEDQKEAAIKAEAYEKAGAIKKKQEKKREKVE
                     KIRERWQKEKTSKNLIVDEGEIADVVSSWTKIPVRKLEEGESERLRNLETILHERVIGQ
                     EEAVTAVSKAIRRGRVGLKDPKRPIGSFLFLGPTGVGKTELSKALSEAMFGTEHALIRV
                     DMSEYMEKHSVSKMIGSPPGYIGYDEGGQLSEKVRRNPYSVILFDEIEKAHPDVFNILL
                     QVLDDGHITDAQGRKIDFKNTVIIMTSNAGAENIISPKRLGFGAVADEKADYKIMKDRV
                     MEEVKRLFKPEFINRIDEIIVFHPLNKTHMKDIVTIMMKDIMKRTREQMSITLEIGEDA
                     KEYLINKGYDEKYGARPLRRTIQNCLEDKLAEEILNGTVKTGDEVAVTAGAEGLKFSVR
                     ELVK"
ORIGIN
        1 acagggaagt ttgccaaaat aattacgaaa tcattgagat ggtccaaatg gcggcaacgc
       61 tgtccaagaa taaccggcgt ctgctgcggt ccatgattct tgtgatggaa gaactggaaa
      121 gagaaaatag aagaaaagga gaatgtaata atggaaaaga ttgttgacgc cagaggtctt
      181 gcatgtcctc agccggtgat taaggcaaaa gaggcattaa aaggcatggg agaggggaca
      241 ttaaaggttc ttgtggataa tgaaatcgca gttcagaacg taatgaaact tggaaatttt
      301 gaaggacttg cccctgtttc tgagaaaaag ggtgaaaagg aatttgagat cctgttccac
      361 gtaagcggaa catccggtca ggtgaaagaa acggtgctgg aggaagaatg cattcccgac
      421 accagaaaga aaggtcttgt ggccgtacta tcctcagatc agatgggggg aggcaatgaa
      481 gaacttggcc gcattctcat gaagggcttt gtgtatgcgc tgacccagtt agaggagctt
      541 cccgaaacgg ttcttcttta taacggggga gccagattgt ctgtggaagg ctcccagtcc
      601 ctggaggatt taaagagtct ggaagcccag ggtgtggaga tccttacctg cggcacctgt
      661 ctgaattact atggaatgtc cgatcagtta agagtaggtg ctgtcacaaa tatgtatgaa
      721 attgcagaaa aaatggcagg tgcccgtctg gtcatgaggc cttaaaaacg tccggtttcc
      781 cagacagggg tagtttttat tgacaaacca ggggatttcg ttctataatt cactcagcta
      841 tttttaacat caaagcagga agattctgca gtaaaaacca tgccccctgc atgctctctt
      901 tctgggggcc ggcccggaac aatggaagtg cccgtaagaa atcttctttc ttccgggtac
      961 tttccttttg accacgggct ttttatctcc aaaggatttt tggaacacgg ttccggcggt
     1021 aaagcttttg aagcatgatg gtacaggaga gggtgaagaa tatttccagt accgtgctca
     1081 cgattccggt caggaaaaag agaaaggcgg atacggctgt tatcatcagc aggcaatgca
     1141 ggtaaggccg gtaaacctcc tggttcatgc agtaaagctt ccagatgatc atatacaggc
     1201 agaccagaag agaaatggat gccaaaaagg ataataccac atgaaggacc gcatgaatcg
     1261 gctgggaatc cggcagataa ggcgtgacga cagccagagc cagaagcaat agggcagagg
     1321 tgctgaccag ggtttccttt ttatttctgg gcaggccgcc tatgatctgt tttagaacgt
     1381 aataaaaata cgttcccaca atgacgcccc ataggaggaa taaatttttc ctgtcagcca
     1441 gattccctaa aacggaaaaa ttcacattga accagtcagt tccccaggca aacaaaatgg
     1501 tatatatggg aataatgaaa taagcggtta tggttaataa ggacataaag cacctccgga
     1561 gatttgtctc ttcctatttt ggcatttaat tcggaaatta ataaggaaac tgcgttattt
     1621 ttatataaaa tttaaaattc agaggaaaaa taatgattca attaccggat gggttcaggg
     1681 aaaaaatgaa agggctttta gaggaggaat atgattcctt tatggaaagc tatcataagg
     1741 agcgggttca ggggctgagg ataaatcctt taaagatttc ccgggaaaat tttatggaga
     1801 tatgtccctt tcagcttaag aagatcccat gggcagaaga agggtattat tatccggctg
     1861 atgaaaggcc gggaaagcat ccataccatg aagcaggact ttattatatc caggagccga
     1921 gcgccatggc tgttgtggag ctcctcgatc ccaggcccgg agagcggatc cttgatttat
     1981 gtgctgcgcc gggagggaaa accacccata ttgcaggtcg gcttaaggga aacggatttc
     2041 ttttaagcaa tgagatccat cccgccagag ccaggatcct ttcccagaac gtagaacgtc
     2101 tggggatcgg aaattgtgtg gtgtctaatg aggattccca aagcctgtcc cggcgcttcc
     2161 ctagtttttt tgaccgtatt gtggtggatg cgccctgctc cggggagggc atgttccgaa
     2221 aggatgagac ggccaggcag gaatggacgc caggtcacgt tacggtttgt gccgcccgtc
     2281 aggaggagat tctttccaat gctgctgtaa tgttaaagcc tggaggaacc atggtttatt
     2341 ccacctgcac cttttcccct gaagaaaatg aacaggtcat agaagccttt ctattttctc
     2401 atcctgattt ttccattaag gacgaaggaa aacggcccgg gctgtccccc ggacggccgg
     2461 aatggagcag aaccggtctg ggagacttaa aaaagacctt ccgcatctgg cctgaccggt
     2521 cagaaggaga aggacatttt cttgctgtat taaaaaaatc tggggagcac atgtctgaaa
     2581 aaaagaaaac gatgccggag tataccaggg acaagactgt gttaacggaa ttggctgggt
     2641 ttctgaagga ttttctggta gaccctgctc ccctgatgtc acggaaggaa tttattcttt
     2701 ttggggatca gctttatctg ctccccccgg aaatgattga ttttaagggc atgaaaatca
     2761 tccgtccggg actgcacatt ggaaccgtga aaaagaaccg gtttgagcct tcccatgggt
     2821 ttgccctttc ccttaaaaaa gaagaggtaa aatgctggat cgacctgccg ccggacggag
     2881 aggagattgt cagatattta aagggagaga ccctgcccca ggatgctgct ttttcccggg
     2941 acaataagaa aggctggata ctggtaaaca ccggaggata ctctatcggg ttttccaagc
     3001 tggccggggg aatccttaaa aatcattatc ccaaaggcct tcggtggatg tgactccaat
     3061 gtactgcatg tccttcggca gaggcgcctc aaaggacaga ggctcctttt tgattgggtg
     3121 aaggaaatcc agccggaagg agtggagtgc ctgacgactg atgtaacggt aatccggatg
     3181 ataaagaaaa tctcccggca aggggtaccc aatggatttt aaatggaccc ggatctgatg
     3241 tgtccggccg gtttccaggc aaagaccaac aagggattgt ccggttacag gatcataata
     3301 aagccgttta taatgggtac gggccttttc tccccggatg aagtccacac accgttcaat
     3361 ggtggaacca tccacccggg caatgggagc gtcaatggtt ccttccaggg gaggctttcc
     3421 gcaggtaata gcaagatatc ggcggcggat ctctcttttt tgcaccatat ccgataggat
     3481 gcaggcgctt agaggatttt ttgccagcac cagaagtccg gtggtgtccc ggtccagacg
     3541 gttgatggcc cggtagacaa aggactcccc cctcttcata aaataatatg ccatgccgtt
     3601 ggccagggta tggtcaaaat tgccctgaga cggatggatg ggaacgcctg cctccttatt
     3661 gactaccagg atatgctcat cctcgtactc aatttgaagg ggcattggag ttgggacgat
     3721 gttttcagag ctttcatctt cacaaataaa gacggataaa tggtcccccg gtttcagaat
     3781 ccgggtggag gatacaggtt ctcctcccac cacaattccg ttggatctgc tgcgcagctg
     3841 ccggataagg ctctgggagt atcctaggtc taagagatac tgttttacgg tcattgcttc
     3901 atgggtttgg gttatggtat aattcatagt cagtttcata aaccgattct accatggagg
     3961 ggagtgattg acaaggagaa tctatgggtt ataattagct ggtagaaaat aaaagaggga
     4021 gttaatcatg tttgatcagg atacttatga agcgctggaa atggaatttg agaaaaacca
     4081 tatcttggag gatgtggagg aggttctgct ggattttgcg gaagcccttg cagataaggg
     4141 tttgatggat aaagaactgg ttttaacgga atcctatgga aagataccaa ttcaggtgtc
     4201 agggatctgc tccgaagaag agggagatgt aaatgtcctc atcaaacgtc tgcggatcgg
     4261 taaaagggaa tttgaaattg acgattattt tctttaagag gaaagcaggg cggaagaaat
     4321 ggaggcagca cacttatgat gacaatcaga caggaatatt cgccgaagga gctgggggtg
     4381 gatctcctgt gcgatctggc gggagcattt ttatttaata ttggaatcta taattttgca
     4441 gtaaacgcag agtttgcacc agtgggagtc tccggcattg cactgattct gcgatatctg
     4501 ttcggcttac ccatgggaat caccagcatg gtcttaaaca ttcctatcgt actggtgagc
     4561 tacaggcttt tgggcaggcg ttttttactc cgttccatga aaagtatgat catctttgct
     4621 cttgtgctgg attatgtggt gccttatctg ccggtttacc agggaaatcc actgtatgct
     4681 tccgcctgca ccgggatttt ctccggtctg ggactgacca tcgtatattt aagaaactgc
     4741 tccacaggag gaaccgactt cctggtcatg gctatccgta agctgcttcc tcaccggacc
     4801 atcggtcaaa tatcacttgt ggtagatgcc attgtaatca ttgccggtgg atttgtattc
     4861 cgcaacctgg atgcagttat tctgggttta gtctcctcca tagtgaccac catggtaatt
     4921 gataagatta tgtatggact gggagccgga aagctggtct ttgttgttac ttcccgcgag
     4981 tcagaggtgg ctcagaggat tgaagaaaat accgggagag gctgtacctt ccttaagggc
     5041 cagggctctt attccttaga tgagaagaag gtggtcatgt gtgcctgcaa caacagccag
     5101 gtggtgccca tccggcgtgc catccatgag attgacaaag aggcttttat tattatcacg
     5161 gattccaacg aagtttatgg cgaggggttt aaagccatcg gaggacagct ttagcagaag
     5221 gggggtgccg gaaaactcat agagttttcc ggtgccccct tattttatgc ctgattttcc
     5281 tctccccgcc gtatgatcca caatggcatc cttttttaaa aagctggctc ttttcacgct
     5341 gtcggtcccg aatttgctgc ggatgcgatc cacagccttt tccatttcct tcatctttcg
     5401 ggtatgctct gattcaaaaa gattaagctg gaaatagcct tcttcagaaa tcttggtggt
     5461 ccgtacaccg attaagcgca ggggagtacg gtcccaaagc tccttaagca atttgcaggc
     5521 attctcataa atgactgcgg tggagtctgt cggattgttt aaagttatct gatgagacct
     5581 ggtctgaaaa ttccagtcct tgatctccac acagatgcag tcggacatga catggtccgt
     5641 ccggagacgg gcacctacgg tctcacttaa ggataacagg acctggcagg ccacatcaaa
     5701 atcgtcgata tcatgggaaa gggtggtgct gtttccgtaa cccttattga aagactcccg
     5761 ctctgccacc ggggaggaat caatgcccca ggcataatca tggattaaaa gcgcgtattt
     5821 ttctcccaaa agaggtttta aatggcttat actgcaggag gccagctctc cgatggtgtg
     5881 tatgccgatg ccttccagct ttttccgggc agaatggccc acaaaaaaca gatcccctat
     5941 gggcaggggc cacattttag aggaaatttc atgggtaaat aaggtatggc agagattggg
     6001 ttttttaaag tccgatgcca tctttgccag gagtttattt ggagccacgc cgatattcac
     6061 tgtaaagcca agttcccgcc atattctttc ccgtatccgg tttgccgcca ctaaaggggg
     6121 gccgaagagg tggatggtgg aggacatgtc cagaaaggct tcgtcaatac tgaatttttc
     6181 catgtcaggc gtgtaatcgg acaaaatttc cataagctgt tcggatttct taagatacac
     6241 atcaaaccgg gcaggaacaa cagtcagtga cgggcatttt ctcagggcct ggctgatgga
     6301 ttccccggtg gagataccaa atgctttggc aggggtagat tttgccaata cgatcccatg
     6361 cctgagagag gcgtcgccgc ccactgccga cggaatggtg cgcagatcca gggcacttga
     6421 atcttcctcc agacgtcgga cggattccca gcttaaatat gcggaattaa cgtctatatg
     6481 aaaaattaag ggttccgttg ccatagttcc tcctcctttg atgtaaaatc tccttttcat
     6541 ttattatacc gaaaatacgt tcggaaagta aagggaataa ttaaaaaaaa tgcggaatag
     6601 gataaaataa attcatgggg gaggctcttt catgaggcat gccataggaa tgttactgac
     6661 agcggtattt gtccttcttt tagtgacagg aactgctggg atcaggctgg caggaaaaga
     6721 ggccgtcaat gagaagacaa cagtgacaga ggagaaagga gaaaagagtg ggtcggttca
     6781 gacaaaggat gaattaaatc tttatgccca gtcagcagtt ttgatggatg cctctaccgg
     6841 ccgcatctta tatgggaaga acgaggatat cgcccgtccc atggccagta ccacgaagat
     6901 catgacttgc atccttgccc tggagtatgg gaatctttct gacacagtga ctgccagcca
     6961 gaatgcatct tcccagccca aggtacattt aggggtttat aagggagaga cgtttctgct
     7021 gaaggacctt ctttacagcc tgatgctgga atcccacaat gatgctgcaa tgatgatcgc
     7081 ggagcacata ggtgggagtc aggaggggtt tgccggactg atgaaccaga aagcaaggga
     7141 tttaggctgc acggatacat actttattac acccaatggc cttgatgcca gggaagaaaa
     7201 agatggacag gtgaaggagc actccactac ggcagctgac ctggccagga ttatgaatta
     7261 ctgcatcgga cagtctccga aaaaaaagga attccttgag attacgggaa cgaaaagcta
     7321 ttcttttacc gatctggaag gaaagcgttc ctattcctgc aacaatcaca atacccttct
     7381 tgccatgatg aacggagcct tttcaggaaa aacaggattt acgggaggag ccggatattc
     7441 ctatgttgga gctgcccagg ataatggtag aatctatacc attgcgcttt taggatgcgg
     7501 ctggccgcct cataaagcct ataaatggtc agatgcaaga aagctgtttc aatacggaat
     7561 ggagcgtttt cattacagga acgtatacaa agacttaagc cttccggata taccggtaaa
     7621 ggagggaatc ccggcttccg gccgtttgga tgaaccggtc accgtatcct gcatcatagg
     7681 aggagaggaa gagaaagact taacccttct tctggcagat gaggaggagg tcacagtaca
     7741 gacagaaatc ccaaaggaat taattgctcc ggtgcgtaag ggtcaggcag tgggaaatgt
     7801 catttaccgt ttaaacggag aggtcataaa aagctatacg gtatgtttaa accagggggc
     7861 ggaccgtctg acaagggcct ggtgtataaa aaacattgtt tctaaataca tttccatgcc
     7921 cggagttaag ggaattctct ccggttttta agaaaaacag gcaggaatta taggaaaggg
     7981 tgggaaatcc ttgtctttcc gtgattcctg tttttcattg tcaggaaatc cgggcatgaa
     8041 cggtttcaat gagatggggg attgcgttcc gtggaaaaca tcttttcaaa ttgatgtttc
     8101 atgcactggt tttggattcc ttcttgtgat atagtaaagg tgtttgttat ccaaggaaag
     8161 gaagtcacaa aagtatgaat atgagaaaaa ttgccacagt tcttgcaggc aataccattt
     8221 atgcccttgc cgtatccctg ttcattctgc cgggggggct gattacaggc ggaaccaccg
     8281 gacttgccct ggtggcctat caccagctcg gcatccctgt atccgtcttt gttgggggct
     8341 ttaatctttt aatgtttgcg gcaggagcca tggttttggg aaagcagttt gcttttacca
     8401 ccatgataag taccttttac tatccgttta tactgggagt atttgaaaat ctcttcggcc
     8461 aggcggctat gaccggggat cgtatgcttg ccaccgtttt ttccgggctt ttcatcggcg
     8521 tgggaatcgg catggtgata agggccggcg cttccaccgg aggaatggat attccccctc
     8581 tgatcctgaa caaaaaatgg aatctttccg tatccatgac catgtcggtc tttgactgcc
     8641 tgatcctgct gtcacagatg atattttcca ataaagagca gatcctttac ggcatcctgc
     8701 tggtgcttac ctattccatg gttcttgata aggtgctttt gatcggacgt aaccagatgc
     8761 aggtgaaaat cataagcgaa aaatatgagg agatcaacca ggccatccag accagaatgg
     8821 acaggggaac cacgctgctt gccagcgagg ggggatattt aagaacggct tcctttaccg
     8881 tccttacggt aatatcaggg agacaggttt ccaggctcaa tgagctggtt atgggaatag
     8941 atccgaatgc attcatgatc attaaccagg tcaatgaggt gcgggggaga ggatttaccc
     9001 ttcataaaga atacaaatag tatacaaagg accggcgaga atcttacaga aaaatgacta
     9061 aggtttacgg tttttgaaac tctattgact tatattcctg actggtgcta tactgtggcc
     9121 gaactagaaa atggacgcag ggaggaacca ggaaaatgct gagaaagaaa atcggtttgt
     9181 tttgttttgc tgctgtattt gttgtagcac tggcagccgg atgcgccagg aaggaagccg
     9241 gagatttggg cggctcactt ccggaagcgg cacaatcaga gactgcggcc gtcaggatgg
     9301 agaaagccag gatagaagaa gaggctgatg atgaggctgc agtaaaagag gatatggacc
     9361 agtcagggcc gggaacagag gccacggagg aagtggaaag taccgggcct ggaaaaaagg
     9421 tggaagcctt tgctgaaaag atccaggaag cggttggaga ccgggatctg caggcatttg
     9481 gcgatctgct gttttatccc tgtgttcttc taacagggga tgaggaaacc atcactctaa
     9541 aaagccggga ggacttactg aagcagaacc cggatatggt atttggagat gatttgatga
     9601 tcgcagtggc caatgtggat actgtttcat tgaaaaagac agaccaaggc gtggtcatgg
     9661 gagaaggaga ttccaggatc acctttcagg aacgatcaga cggcagctat gggataacag
     9721 aaatcaggga ataggcagaa aaaagcctgt tgataaaaaa aaaccaaggc gaaccaccca
     9781 gaaacaatga ttgtgataaa atgctaacat aaaaaaaggg caggaaatga tggattgtaa
     9841 gaaattcata atttcctgcc cttttttatg tggaaagtac ttgaaatttg cctaaattag
     9901 ttatacaatt ataattggca taaattggtg ttattctata tttctttgtt aataacttaa
     9961 caaagaaata taaaaaaatt acaaaatgga ggattgcaaa atgagtaatt caacagaaac
    10021 atcggcaagt gatcggattc atgctttgct tgatgagaac agttttgttg aagttggcgg
    10081 ctatgttacc gcaaggagca cagacttcaa catgacggca aaggaaactc ctgctgacgg
    10141 cgttgttaca ggctatggta ccgttgaagg atgccttgtt tatgtgtata gccaggatgc
    10201 atcagttctt ggcggctctg taggagaaat gcatgcaagg aagatcacga aactctatgc
    10261 catggcgatg aagactggtg caccagtcat cggcctggtt gattgtgcag gtctgaggct
    10321 tcaggaagca accgactctc ttaacggatt tggtgaaatc tatatgagcc agaccctggc
    10381 atccggagta attcctcaga taacagcaat atttggaacc tgtggcggcg gcatggctgt
    10441 ttccgcagca atggcagact tcaccttaat ggaaaccagg ggcggcaaac tatttgtgaa
    10501 ttcccccaat gccattgagg gaaattatac aggaaaatgc aatactgctt ccgcggacta
    10561 tcaaagcagg gaaaccggcc tggtggattt cacgggagat gaggatgaca ttttaaataa
    10621 aatcaggact cttatttcca tacttccttc caatagtgag gatgacatgt cttatgatga
    10681 gtgcagtgat gatttaaacc gtgtttgctc cgatctggaa aattatgtgg gagatacggc
    10741 ggtcgcattg gcacagattt ccgataatca gttctttatg gagaccagga aggaatatgc
    10801 ggcttccatg gtaaccggct ttatccgttt aaacggcatg acagtgggct gtgttgcaaa
    10861 cagaacggag tcttataatg aaagcggcct taaaacagca gaatacgatg ccttattaag
    10921 cgggcagggc tgtgaaaaag ctgcaagatt cattaatttc tgtgatgcgt tcagcattcc
    10981 tgtacttacc ttagtaaatg taaaaggata tgaggcgact ccatgttccg agaaaaggat
    11041 tgcaagggct gccgcagggc ttacctatgc ctttgccaac gccactgtgc ccaaagtaac
    11101 ggttattctc ggtcaggccc ttggaacggc atatctgact atgaacagca agtccattgg
    11161 agccgatgtg gtttatgcct ggccgtctgc gaccattggc atgatggaac cgtccgaagc
    11221 ggtcaagatc atgtatgccg atgagatatc gaaagcagag gatggaaagg cccttattaa
    11281 cgataaggca gaaagctacc gaagccttca gtccagtgcc ctttctgcgg caaagagagg
    11341 atatgttgac gatatcattg atgccggtga aacaagagcc cgtgtcattg cggcatttga
    11401 gatgctgttc acaaagagag aggatcgtcc cgcgaaaaaa catggcacga tatagaatga
    11461 ggtgacaggt atatgaaact gaatatgaaa cgagtagcat tgggactaat tatggcagtc
    11521 tgcctctttt cattatctgc atgcagcaaa gccgataccg gatcacagga aatcgatgcc
    11581 ggtgtccaga cgcagatgga gaagcttccc ggttctttcc tggaactgta tgccggtctt
    11641 gaagacagcc aggtggctga atttaagaag aacatgctat cccaggatca gtatgctgct
    11701 ttggcagagg gagtggattc ctgggaaaat gtaaaagatg atcttggggc tttggtatcc
    11761 attggcgata cagtaaaggt agaggccatt gatcatggat acagcgccac ggttgatgcg
    11821 gcatttgaaa agagaaatct ggagttttct attacaacgg atttaaagct tacaaagatc
    11881 accggtgtgg cgtttgtacc ggaatatacg ttgggcgaac ggatggaaaa ggctgtgttc
    11941 aataccctga tgggcatggg taccgtattc cttgtactga tttttatcag cctgctgatc
    12001 gggggctttc agtatatcgg taaatttgaa tcgaagatga agggcaaggc gcaggagcct
    12061 gctttacagc caattcctgc agctcctgtc cctgttgcag aagaggcaga agaacttgtg
    12121 gatgacttag agctggtggc agtgatcacc gcagcaatcg cagcatctac aggaggttct
    12181 ccccagggtc tggtggtccg ttccatcaaa cgagcaccgg tcagtaaatg gaaaaaagct
    12241 taatcaatca ggaggatgat catcatgaag aattatacaa ttacagtaaa cggaaatgta
    12301 tatgaagtaa ccgtggaaga aggctcatca ttaagtgcac ccgcagcggg taagaaacca
    12361 tcggctcctg taccagcggc agctccggcc ccggcggcag ctccggcagc ggctcccatg
    12421 aaagcagcca gtgcaggtac ggaaggctct gtcaaggtgg cagctcccat gccgggcaag
    12481 atccttggcg taaagaccag cgcaggccag gccgtaaaga aaggcgatgt gcttgttgtg
    12541 cttgaggcta tgaaaatgga aaatgaaatc gtggcacctt ccgatggaac agttgccggc
    12601 gttaatgtag cggtgggcga ttcagtagaa gcaggagcaa ccttggctac attaaactag
    12661 tacggaagga tccgctgaac actcaataga gcggattcca tatggaggga ttaacatgga
    12721 ttatattggt aatacattta acaatcttct tcagcagacc gcgttcttta acctgaccgc
    12781 aggaaatatg atcatgatcc tggtagcctt tgtgttttta tacctggcta tcaggaaagg
    12841 gtttgagcca ctgcttctgg tgccgatttc ctttggtatg ctgttagtca atatctatcc
    12901 ggatattatg aaggagactg gagcagatgg ttccggaggc ggactgctgc agtatttctt
    12961 taaactggat gaatggggca tcctgcctcc cctgattttc atgggcgtgg gagccatgac
    13021 ggatttcggc cctctgatcg ccaacccaaa gagctttctt ctgggtgctg ctgcccagtt
    13081 cggaatttat tccgcttatt ttctagcgat atttatgggc tttaacgata aggctgctgc
    13141 ggccatctcc atcatcggag gagctgacgg gccgacttcc atattccttg cagggaagct
    13201 gggaatgact gctctcatgg gacccattgc ggttgcggct tattcttata tggcgctggt
    13261 gccaattatc cagccgccga tcatgaagct tctgacaacg gagaaagaaa gaaagatcaa
    13321 gatggaacag cttcgtcccg tatcaaggct tgagagaatt ttattcccta ttattgtaac
    13381 aacggtagta tgtatgattc ttcctacaac ggcccccctg gtgggcatgc tgatgttggg
    13441 caacttattt aaggagtccg gtgtagtgaa gcagttaacg gagactgcag gcaatgccat
    13501 gatgtatatc gtagtaatcc tgctgggaac ttccgtaggt gccaccacaa gcgcggaagc
    13561 attcctgaat ttaaacacca ttaagatcgt ggttcttgga ctggtggcat tttccatagg
    13621 aacggcagcc ggcgttcttt ttggcaaact gatgtgcaag gtaaccggtg gcaaggtgaa
    13681 tcctctcatt ggttccgcag gagtatctgc tgtccctatg tctgcccgtg tatcccagaa
    13741 agtgggcgct gaggcagacc ccagcaattt cctgctgatg catgccatgg gaccaaatgt
    13801 ggcaggcgtt atcggtacgg cggtagctgc cggtacgttt atggcaatat ttggagtaag
    13861 atgatttggc gtcataccca caggtctttc gggaatatgt tctatggcca aatgatcaat
    13921 ggcatggctg aactatagcg gcacttggaa gggctttatg cctttctgtc aatcagataa
    13981 atgaacaata accaggaggt aagacaatgg cagaaataga aaaaaagccg gttaagattg
    14041 tggagacagt ccttcgtgac gctcaccagt ctttgcttgc tacaagaatg actaccgaac
    14101 agatgcttcc cgttgtggag aagatggatc gggttggtta tcatgcggtg gaatgctggg
    14161 gcggtgcaac ttttgacgca tgccttcgct ttctgaagga agatccttgg ataaggctta
    14221 gaaagctgag agatggcttt aaaaatacaa agctgcagat gctgttcaga ggacagaata
    14281 ttctgggcta taaccattat gcagatgatg tggtagagta ttttgtgcag aaatccctgg
    14341 ctaacggcgt tgatattatc cgcatctttg actgctttaa cgatctccgc aacttacaga
    14401 ccgcagtgac tgcctgcaac agggaaaagg gccatgcaca ggtggctttg tgctacactc
    14461 tgggagaggc ctataccctg gactactgga aggacattgc caaaaggatc gaggatatgg
    14521 gagcggattc tatcggaatc aaggacatgg cagggctttt aacgccttat aaggctgacg
    14581 agctggtgcg cgctttaaaa gagtctacaa cccttcctat tgacatgcac actcattaca
    14641 cctccggtgt tgcatccatg acctatttaa agggagtgga agcaggctgt gatattattg
    14701 atactgcaat gtcacccctt gctctgggaa ccagccagcc ggcaacggag gtcatggtgg
    14761 agaccttccg gggaacccca tatgatacag gctttgacca gaatcttctg gcagaaatct
    14821 gcgcatattt ccagccgatc cgggaggaag ctttaaagag cggacgctta aatcccaagg
    14881 tattaggcgt ggatatcaag acccttcagt atcaggtacc cgggggcatg ctgtccaacc
    14941 tagtcagcca gcttaaggaa gcaggtcagg aagaccgtta catggatgtt cttcaggaga
    15001 ttccaagagt aagaaaagaa ttcggagagc cgcctcttgt tactccgtct tcccagatcg
    15061 ttggcactca ggcggtattg aatgtcataa gcggggaacg atataagatt gtaacaaaag
    15121 agactaagaa gatattttta ggtgagtttg gacagacggt taagcccttt gatgcagagg
    15181 tacagaaaaa gatcatcggt gatgagacgc ctattacctg ccgtccggca gatttaatcg
    15241 ctccccagct ccctcagttt gagaaggaat gtgcccagtg gaagcagcag gatgaggatg
    15301 ttttatccta tgccctgttc ccaggcgttg caaaagagtt ctttgagtat cgggccgccc
    15361 agcagaccgg cgtggattct tctatggctg ataaggaaaa taaggtttat ccggtataat
    15421 tatataatat gtttgatttt attaagctta ttcaggtgtc cgttatggat gcctgaataa
    15481 gcttttttct atggaagctt ttatgaaacc ttctgacgtt tgaggtgttc ctttgcaact
    15541 actgcaaaaa tgctcctttt ccatggttga tttgtttgct gggtttttat tctcttatga
    15601 tgccggttta tgatctgcct tgttccaact ttaaagattt tcttacaaat atttccattt
    15661 gtctgaactt tagctgattc ggttgacaca tggtatcatt tgtcattata ataaataaat
    15721 gtattattta catataactg gaaatttaaa aatacaagag gacatattgg gagaaacaca
    15781 tgaaaaagta tagaaaagct cgtaagatgg ccattatcct ggccagtgtc ctggtgatgg
    15841 actcttatac gggagttatt tcgccataca taaataccta tgcctatacg gaaaaggcag
    15901 caaccgtaaa tgctacctcg ctgaatgtaa gaagcgggcc tggcacgacc tattctgttg
    15961 ttacaaagct gacgaatggg gcatctgtaa ctgtgattga tgaaaaaaat gcttcggatg
    16021 gagcgctttg gtatcagatc cgtgtgtccg gttcaggagg ccagaaggtt accggatatg
    16081 tttccaaaag ctttctccgg tttccggcat cctatacgaa tgatgcggat tttgagtccc
    16141 ggctaacggc agaaggcttt cctgaaagct ataaggtgag gctgcgtgcc cttcatgccc
    16201 agtaccccaa gtgggtgttc cgcgcccagc atacaaatct tgactggaac acagccgtta
    16261 aggaagaaag cctggctgga aagactctgg ttcacaccaa cagtctgtct tcctggaagt
    16321 ctaccataga cggcgcttac aactgggaca ccagcacatg gatcggatat gacggaagct
    16381 cctgggtcac tgcttctgca gatattgtga aatattatat ggatcccaga aactttcttg
    16441 atgaaaccaa tgtgttccag tttatgaccc atacatatga cagcagcaaa catacggcag
    16501 atggattaaa gaccatggta aagggaacct ttctatccgg cgaatcttcc ggaggaagcg
    16561 gcggcaacgg cagtacaccg ggaaatacag actcatccgg aggcggcacc gtcatagggc
    16621 caggggcagc catagggccg ggggcatccg tcagcccatc cacaggggca gcccaggatt
    16681 ccggctcagg aaaggccagc ctggagggac cccaggcgtc cataacgccg aaaaaccttc
    16741 cggtccttat ggaatacgga cctggagcca gcctttcggg accgtcctct tccaattcgt
    16801 caggaaccgt tacaggcagc agcgcctatg tgaacatgat catgaatgcg gcagcccagt
    16861 caggagtaaa tccttacgtc cttgcggcta tgatcattca ggagcaggga tcttcaggag
    16921 caggcaaaag tatttcaggt aaagagcctg gttacgaagg atattataat ttttttaata
    16981 tagaagcgta tcagtccggt tccatgactg cggtgcaaag aggcttatgg tgggcatctc
    17041 aatccggcaa ttatgaacgg ccctggaatt cacctgaaaa atcaatttta ggcggagctt
    17101 tctattatgg taataactat gtaaaagttg ggcaggatac tttttatctg aagaaattta
    17161 acgtacaggg gtctaattta tataaacacc agtatatgac caatgtgcag ggagctgcat
    17221 cagagggggc tgtttattca aaagcctata acagtgacat gaaacagaca gagcttgaat
    17281 ttaaaatccc tgtttataac aacatgcctg ataatccatg cagccagcca acaggtgacg
    17341 gcaaccccaa taataaactg tcaggcttaa gcgtggaggg ctttgcaatg actcctacct
    17401 ttagccgtga tacgctggaa tacaacctga ttgtggatcc cggtgtgtca agcatcaacc
    17461 tgtatgcaac acccctcagt tctctggcct ccgtcaacgg aaccgggacg atcacacttt
    17521 caaacggcaa taatgatata aaggtggcgg ttaccgccca aaacggcagc gtaagggaat
    17581 atgtcctcca tgtcgtgcgt cagagcaacg gcccgactta ttcctcagga gtaggagcca
    17641 gtcctggggg caacgcctct tccggacagg gcagcagcag ttcgggaggc aacccctctt
    17701 ccgggccagg cagcagcagc ggaccgggag tatccaagcc ttccggcact gacaatgcag
    17761 gcacaccggg aggaagcaat gtaaccatag cgcctaatgg ctccgcgaac atttccgtac
    17821 agacctctac gggagttatt tcccagggac cgggcacaga catcaaggtg acggaagcag
    17881 cgttagggag tccgcagcag acacaggctt ctgctgccgc aggccagtca tctgcctatg
    17941 caaaaggtga tatcaatggg gatggaaaaa taaacagtct ggataccctg aagcttcagc
    18001 gttatcttct gggtctggaa accattccgg agaaaggcat gctttcagcc gactttaatg
    18061 gagacggcaa agtgaattca caggatcttc tgcttttgca gaaaaaaatc ctaggacttt
    18121 aatttgcgcg agcaaggagt ccaatgactg tgcctgcatt ttcattgggc gaatcccgcg
    18181 gcaactaagg aaaacccgct aagtgtgtct tttcttagtt gtccaactaa aataggagat
    18241 aatatgaata ggaaactaaa aaaactgacg gccggtttga tgctggcctg tgtgattgcc
    18301 atagccggcc cggccggccg gctggtatcc tgggctgcgg atgccaagat cgcattttcc
    18361 gatccatcgg ttatggtggg gaacgaagtg acggtaagca tgaaagtgac cagtgacagc
    18421 ccgcttggca cagcggaaat catgctggct tacgatccca atgttttgga gttcgtcagc
    18481 ggaaccaatg caaatggcgg tgcaggagcg attaaggtct tgggaaccat ggattcagcc
    18541 aatcagaaag cctttagctt taccctgaaa tttaaggctc tccaggctgg taatactcag
    18601 atcagcgtaa cttcccagga aatttatgat gtggattccc aggctctttc tttaagcaag
    18661 cagggaagct cgtcggtaaa ggttacatcg ccagccacat attccaagga tgcaacgctg
    18721 aaatcgttaa agatttctcc gggaaccctg actccaggtt tttcccctac ggttgacagc
    18781 tatggggctg aggttgacgc aaatacaaca gatctggtgg taaatgcagt ggcagccaat
    18841 gcgggagccc acgtaagcct tcagggcgag aagggcttaa aggccggaac aaaccaggtg
    18901 gttgtaaagg taactgctga agatgggcag acaataaaga attataccat tcaggtaaag
    18961 aaagcagagg ggggagaaac agtccctgcc acgggaggca gcacggaacc gtctgaagcc
    19021 gaattcggag ctgcaacggt gaccatgaac ggaaccgaat acagcattgc gacctccttt
    19081 gatgaagcat cgcttccgga gggctttgaa gccgggactt attcctataa gggaacagaa
    19141 gtcatgtccg gaaaaggact ggaaaaagac cttctactgc tttatttaaa ggactcagga
    19201 ggaaacggcg ggttctatat ttataacgaa ggctcagatt cctggtccca gttcgtacag
    19261 gtggaaacta ttgcaaaggc cattgtgatt ctccctcttg atggagatgc tgcattaccg
    19321 gatggcttcc gtgaacgcca ggccgatata gatggcgtac gtgtgaccgg ctgggtggaa
    19381 aactcagaag ctgagcctca gtattgtctt ttctatgcaa tgaactggaa tggagaaaag
    19441 catttctacc gctacgatct tacggaaaag accattcaaa gatactatgc ttccggagta
    19501 tccaatgagg aatatgtgaa aatggtcaac acatacaacc agctaaccaa ggattaccgc
    19561 atccagttct atattctcat tgcagtaagt gtcatggctc ttggcttgct ggtagctgtc
    19621 atcattcttg tgagaaaagg aggcagatcc gatcccggca ggtccggcag ggacagtatg
    19681 ggaaaaggga agacagagaa agcagctgat ggcaggatgt gggcggaaac tgaggaagaa
    19741 atccctgcaa gcaagatcaa aagatacacc agggaagagt ttgacagaga gaattccaag
    19801 tcagaaggtt tcagagccga tggccctgcc tccccaatca gcccggaata ccaggaagaa
    19861 tccatggaca tgcctgttga tatggctgaa ggagaacagg aaaacccgga agaggatgat
    19921 tttatcctgg agtccagtct ggaagacctg gaacggaatc tggcgctatc tcaagaaaga
    19981 catcctgtta ggaccaacgg aaagagcggc caaagaccgt tgggaaagga gcggggacgc
    20041 tttcaggaag tggaggaatc tggggaagat gaggacgact ttgagttctt ggatctggat
    20101 gattaagaaa atgtaaataa ccggattcta tatggttgga ttatttgaac ggaattttaa
    20161 ataattatct cacaaataac ggaaaagaaa gtaacgaaag cacctgaatg aaggtgcttt
    20221 cgttataagt ttttgttagt tgaaagagag gctttcatga caaaagtgat gttacggttt
    20281 aattgaaacg gaatacggga taccagaata gctgtctggg tactgaaaaa ataaattgat
    20341 atttttcaga atttaaccat ataatgtcca ccaggacagc acccagataa cattaaaaag
    20401 gggaattata ccaaaccata ttttatgttg aaaaaagcgg cggtttgtgc tatcatgtgt
    20461 ataacagata taacgaaaga tggtgaaaat atgttcttgc aaattgattt taatagtgat
    20521 gaagcgattt atattcagct tcggaaccag atcatcatag gaatcgccag gtcaaatata
    20581 agagaaggag accccctgcc ttccgtacgc cagatggccg acaacatagg tattaatatg
    20641 catacggtaa ataaggcgta ttctgtgctg aaacaggaag ggtttgtcaa gctggaccgc
    20701 cgcaaagggg ccgttgtatc tctggacgtg gataaaatcc aggtccttga cgaaatgcgt
    20761 agagatttag gcgttgtgct ggccagagga gtctgtaaaa atgtgacgtg tgaagaggtt
    20821 caccagttgg ttgacgaaat tttccagtca tttttaaaga gtcagatgga agagtgattc
    20881 actggattgg aggttcatta tgttatgtga aaaatgtaag attcgcgaag ctaatataca
    20941 atatacagaa gttgtaaatg gaataaagaa ggagcatcat ttttgcgccc agtgtgcaaa
    21001 agagatggat tttggtgtgt atgcagctat ttttgatggg gagtttcctt taggtaagct
    21061 gctttccggt cttttgggga ttgaggataa ggatcaggga ccggataaac tccatcagat
    21121 cacatgtcct gcctgcggga ccagctatga ggagtttgtc agggacagca gatttggctg
    21181 cgccgactgc tacggtattt ttggccctct catggaggac agtttaaagc agcttcatgg
    21241 aaatctggtt catacaggaa aaacgccggt atatcagaag ccggattata tgcctttaag
    21301 tctgggaacc ggggaaaact ccagtcagga gaaggatggc cccggcggaa tatcatcaaa
    21361 tcccaataac ataggcggac gtgaggaaat ctttcagtgg gatgcccggc tgaaagaagc
    21421 cttacgtttc gaggattatg aaacggcagc cgtatgccga gacaagatca gagagctgaa
    21481 gaaaggatat gagacaaatg cttagatggt ttgaacagaa ggatactggt cggcctggag
    21541 taataagcag ccggatccgc ctggtcagaa actggcagga ttaccggttt cccgcagccc
    21601 tggatgataa ggaaagcggg gaaatggtcc gcaagctgga atttggctta aaggatttgg
    21661 gtaaggatga aggcaggatt tatgaatttt ccatgcttgg agagctggaa gagctggacc
    21721 gggcggccct tagggagcgg cgtattttga attcagcagc cgtttccaat aaaaaacctg
    21781 ctggcctcct ggtctccgaa aatgaagaca ccggcatcgt gtttaactgc gatgaccaca
    21841 tcaggatcca gcttctccag atggggcttc atctggaaga gctttgggaa agagccaaca
    21901 agatcgatga ttacatcaac gaacggtttg cctatgcctt tgatgaccgt tatgggtatc
    21961 ttacctcctt ccccactaat gtggggaccg gcttaagggc ttcggtggtg gtgcacctcc
    22021 ccatgctttc ccagggaagg aaattccagg gccttatcag cgatatgggc cgcttcggag
    22081 catctgtccg tggcgttcat ggggaaaggg atgagaattt cggttccctt tatgagatat
    22141 caaaccagaa aacactggga cagacagagc gggaaatcat agatacggtt tcaaaagcgg
    22201 ccatacagct gaccaatcag gagcttcagg tgaggaagct ttctatgcag aggcaccggg
    22261 aagagagaga ggatgaagtc tataaatcct acggggtatt aaaatatgcc agaaggctga
    22321 cttccaggga tgccatgatt ttcttgtcac agatcatggc ggggctggca gacggcctga
    22381 ttcatacaga ggaggacttt tccgtctacc gtctgatgct tggtatccag ccggcgaatc
    22441 tgcagaagat ttccgaccgt cccttaagca aggaggagct ggatggagcc agggcggaat
    22501 ttatccggag ggaattgccg gaactatgag aaattgcctt tcgagtttct tatagcgacc
    22561 gcgacagtgg ccgaaagagc atgcctgcat gttttcccgg ttcattgccc gcgtaaatga
    22621 aaatgacagg aggattgcat ttatgataga cagatttacg acaaaggcca ggacggccat
    22681 taatctggcc gtacaggcgg cggagcgtct cggccacgga tacgtgggaa cagaacacct
    22741 gttaatcggg cttttagaag agggcggcgg agttgccgcc agggttctgg aagagaatgg
    22801 agtaaaggaa gataaagttt taaaccttat tagccaatta attgccccgg accaggcgct
    22861 tcgtttaaaa gaggatggag gatacactcc cggtgcaaga agggttttgg aaaacagtta
    22921 ccgggaagcc gtacggttta aggcaaactt aatcgggaca gagcatttgc ttatatccat
    22981 tatccgggac aacgactgtg ttgcctccag gcttttaaat accataggga tcagcatcca
    23041 gaagctttat atcgacgtgc tgtcagccat gggcgaagac gctcctgcaa ataaagagga
    23101 gctgatgaaa tcgccaaagg caaaaggaag cactccaacc cttgacagct acagcaggga
    23161 tctgacggag cttgcggcac aggggaagct tgaccctgtt attggaaggg agtctgaaat
    23221 caaacgcctg atccagatcc tcagccggag aaccaagaat aatccatgcc tgatcggaga
    23281 gcctggagtg ggaaagacag cagttgtgga gggcctggca cagatgatag ctggaggaga
    23341 tgtgcctgaa accattgccg gaaaaagact tctgaccctg gatttatccg gtatggttgc
    23401 cggttccaaa tacaggggag aatttgagga aagaattaaa aaggtgatcg ccgaagtgat
    23461 cgatgatggg gaagtgcttc ttttcattga cgagattcat acgattatcg gagcgggagg
    23521 agcggaagga gccattgacg cctccaacat tttaaagccc tcccttgcaa ggggagaact
    23581 gcagctgatc ggtgcaacca ccattgaaga gtaccggaaa tacattgaaa aggattctgc
    23641 tctggaaagg cgtttccagc cggttaccgt agaggaacct tccgaagagg cagccatcgg
    23701 aatattaaga ggccttaagg gacggtatga ggatcatcat agggttacca ttacggatga
    23761 tgcattacaa gcggcggtga agctgtcttc ccggtatatc aatgaccgtt ttcttccgga
    23821 taaggccatt gatgtcattg acgaggcttc atccaaggtg cgtctgacca catatgtaga
    23881 gccggctgag attaaggagc tggaagctga gatcgaattg ctggaggatc aaaaggaagc
    23941 tgccattaag gcggaagcct atgaaaaagc gggagctatt aagaaaaagc aggaaaagaa
    24001 acgggaaaag gtggaaaaga tccgggagcg gtggcagaag gaaaaaactt caaagaacct
    24061 cattgtagat gagggagaga tcgctgatgt agtatcaagc tggaccaaga tccccgtaag
    24121 aaagctggaa gaaggggaga gcgaacgtct ccgcaatctt gagaccatcc ttcatgagcg
    24181 ggtgattgga caggaagaag cggtcaccgc tgtgtcaaag gccatacggc ggggaagagt
    24241 gggccttaag gaccccaagc gccccattgg ttccttcctg ttcttaggcc ctaccggtgt
    24301 ggggaaaact gagctttcaa aggcgctttc cgaggcaatg tttggaacgg aacatgcttt
    24361 gatccgtgta gatatgtcgg aatatatgga aaagcacagc gtttccaaga tgatagggtc
    24421 cccccccgga tatataggat atgacgaagg cgggcagctc agcgagaagg tccgcaggaa
    24481 tccatattcc gtaattttgt ttgatgagat tgaaaaagcc catcccgatg tgttcaatat
    24541 cctgcttcag gtgctggatg acggtcatat caccgatgcc cagggacgga aaattgattt
    24601 taaaaacacc gtcattatca tgacctccaa tgccggagcg gaaaacatca tatctcccaa
    24661 gcgtctgggt tttggcgcag ttgcggatga aaaggctgat tataagatta tgaaggaccg
    24721 ggtaatggag gaagtaaaac gcctgttcaa gccggaattc attaacagaa ttgatgagat
    24781 catcgtattc catccgttga ataagaccca catgaaggat attgtgacga ttatgatgaa
    24841 ggatatcatg aaacggaccc gggaacagat gagcatcacc ctggaaattg gagaggatgc
    24901 caaggaatac ctgattaaca agggctacga tgagaaatac ggcgcaaggc ccttaaggcg
    24961 taccattcag aactgcctgg aggataaact ggcggaagag atcttaaatg gaacggtaaa
    25021 aacaggagat gaagttgctg tgaccgcagg tgcggaggga ttaaaatttt ctgtcaggga
    25081 gctggtaaaa tagctagcca ttttaaatca attcgtgtat aatagctaca agcgagtcat
    25141 ctgttcatcg ccaataggga taagtaaaca aaatactagg agggcaaacc aatgccggta
    25201 attgaagaat taatccgcac agagcaagac gggaccatca gttttgggaa tcacaaatta
    25261 aagacaaagt caaagctgca ggattttgag cacgatggtg atttatataa agtaaaaacc
    25321 ttttatgaga taaccaagct ggaacgcaac ggtatgtttg tatatgaatc cgtgccggga
    25381 acgactgcca tgaatttcac cgtatcagat gatggagtg
//
