LOCUS       c00080_NZ_FQXK..       15577 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_FQXK01000040.1 Butyrivibrio fibrisolvens DSM 3071, whole genome
            shotgun sequence.
ACCESSION   NZ_FQXK01000040
VERSION     NZ_FQXK01000040
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 01:20:59
            Original ID  :: NZ_FQXK01000040.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15577
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..207)
                     /locus_tag="ctg80_1"
                     /transl_table=11
                     /translation="MNFTQNDRLKQVTANTLIVGVDVGSQTHFCRAFDWRGFELSRRVF
                     KFSNDRMGFLTFLRWTEELMNKTE"
     protocluster    1..15577
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[535:5577]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      536..5577
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15577
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15577
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(536..1060)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg80_2"
                     /sec_met_domain="ALS_ss_C (E-value: 8.7e-32, bitscore:
                     100.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADTEVKTYKKVFQLLVDNTSGTLSRISGLFSRRGYNIESITAGT
                     TADPRFTRITIVASGDDDILEQIEKQVAKLVDVRDIHELKPGDSVYRELALVKVKADVD
                     QRQQIIAIANVFRGNIVDVSNESLIIEITGGQDKIDAFLKLLDGYTILELARTGLAGLG
                     RGIENVVYLDE"
     CDS             complement(1491..3437)
                     /locus_tag="ctg80_3"
                     /transl_table=11
                     /translation="MFCPNCGKELPDGSKFCGFCGADISKEQKGNDAINGGMNDAATGM
                     GGQSFGGYDPLGNGQGMSQPDNGQFYGGQNTNQYGGQFNQFDNNQYSGGQFDNNQYYNN
                     NQYGAQQFGAQNPNMQYGAYGPMNQQPQPPKKSKKGIIAAIVSVILVLVIGGSAAAYHF
                     ISADKAKKKDDDDDKKIDVATSASTEEEEKKDDSSNAATEATTEPEEEEISGEEALELA
                     CENLSKVKDMTTEFSYVMECTMAAPDEGVSGDVVESAEFKIVTDYDVNAKNSDADALEL
                     AEGTVSREILGVEFDQEISVFRGDISGSYVSGIEYDTGERYVASESEVVTELLGFYDYD
                     VYKAELQDKTEKVDGVECYVYVSEDTYDQGGISGVFSPISGIYNGDTDLCTVTIYVSKE
                     DAQLVKVETEFTDIQDEPLQDSLRTYTGADDIEFTMDKLEYSLTFVEFDTGVDIDPDFE
                     DLDDETVNVYTSFMLYLGGLLEMGDFDFTDTDDDVTEDDKTKYITDTYGALTYEVPEDW
                     YGQEVDMSDDMSGYIYAPDKNAMSGILVMYSEVDTTSLTDSQLKQGIDSVLIYVADSYG
                     VSYDEKDIKKGTVNGGYAENVRGPVDGSDMEMDIMVFETGGSGIGIVIFISEDIENSEY
                     LAQYYHLLESLEF"
     CDS             complement(3437..3934)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg80_4"
                     /sec_met_domain="ALS_ss_C (E-value: 7.3e-25, bitscore:
                     78.7, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIYSVLVENRTGVLSKVAGLFSRRSFNIDSLTVGETEDPTVSR
                     MTIVSSGDKAILEQVEKQLNKKLDIIKVKTFDEPASISRELMLIKVKYNKSNRRDIIEN
                     CDIMKAQIVDMSKSYMMIQICDVPERSQLLLSMLRGISIVEVARTGTLALTKCVENENG
                     GK"
     CDS             complement(3949..5577)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg80_5"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.7e-43, bitscore:
                     138.2, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGADAIVECLKKENVEILFGYPGVAIAPFFNSLLNSDIKSVLIR
                     TEQNAAHCASGYARISGKPGVCVVTSGPGATNLITGIATAFADSIPLIAITGQVNSSMI
                     GSDVFQEADITGAVESFVKYSYLVRNVNDIPKIFKEAFYIANSGRKGPVLIDIPIDIQQ
                     AQINKFSYPETVSMRTYKPTVEGNMAQIKKLVKEVERSKKPVMCVGGGVHLSDAAQEIR
                     DFAAKCQIPVVSTMMGLGTITNDNPLYFGMVGNNGRAYANKALKDSDLVLMVGARVADR
                     AVNRPELITDNTVLIHIDVDPAEIGKNVGPTIPLVGDLKHIFTKLNTIDINARDHKEWL
                     EFLTDYKAGHPDPRPDISKEYVDPKEFLGKLAKAMDDNGVFVADVGQNQIWATAFFRIK
                     EHQRFMTSGGMGTMGYAIPAALGAKLADPDRQVVASCGDGGFQMSMMELATMDQQKVPL
                     KIIVYRNNYLGMVREYQHYSYKDKYAMVDIAGKPELDMIAKAYGMDYQKIDGGSDIDKE
                     IKDFLNNEHAVLLEVMTDPMDLAKG"
     CDS             complement(5701..8214)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) B12-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pterin_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg80_6"
                     /sec_met_domain="B12-binding (E-value: 1e-24, bitscore:
                     78.5, seeds: 91, tool: rule-based-clusters)"
                     /sec_met_domain="Pterin_bind (E-value: 2.3e-32, bitscore:
                     104.1, seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LTRQDFENFFKNNHPIFLDGATGTNLMKAGMPAGVCPEEWILNHR
                     DVMIDLQRRYANAGSNIVYAPTFTASRIKLKEYGLEDKLVQMNTDLIKLSKEAVEGKAL
                     VAGDITMTGRQLQPVGDLSFEELIEVYKEQIKVIDEAGADLLVVETMMSLQECRAAMIA
                     AKEVSDLPVMVTLTFEGDGKTLYGTTPECAAVVLESLGACAVGANCSTGPDKMAAVIRR
                     MAQVTNIPIIAKPNAGMPSVVDGQTIYDMQPSEFADDMELLLNSGASIIGGCCGSTPDF
                     IKALKDKFTDFDTTSARDEEGNPLTRGDKSLRRLTSERELLSFSLNDPFMIVGERINPT
                     GKKKLQAQLREGSLDMVCDFTTKQEEDGAAILDVNVGMSGIDEHEMMMKVLNEVIQLTS
                     LPICIDSSNVDVMEEALRWYPGRALINSISLEEGKAERCLPLAKKYGAMFILLPVGRDG
                     IPTTIEEKIANIKELTDMALSYGLTKSDIVVDGLVATVGADPEAAIKTLETIQWCYENG
                     YATICGLSNISFGLPQRSFINTAFLTMAIDRGLTMAISNPSQELLVNAAFASDLLKHKE
                     ESDLRYITRMQRYDGDAGKIAVSISGSSASNAASGTGTPTDEKSSDPIQRNMDILYKDV
                     MGGNKRKIAQNTQTAIDAGCEPAKILNDVLMPAINDVGAKFDKGTYFLPQLIASAEAMK
                     LSIAVLEPLLKQSGEQSEPKGTVIIATVHGDVHDIGKNLVALMLGNCGYRVIDLGKDVE
                     SELIIETAMKENAKIIALSALMTTTMVEMKNVIQLAKERGCTAKIIIGGACVTEDYAKE
                     INADGYSTDAADCVRVVNELMEQTA"
     CDS             8954..9505
                     /locus_tag="ctg80_7"
                     /transl_table=11
                     /translation="LNFIKRNITILSILLVSVIGLCGCGKNSELESYKTSMKTFFTEVS
                     DCNDAMNSIDPNADDAPAQLLTYIDKLNASFATMATLEVPSEFKAAEGLADEAADNMAK
                     AAISYHEAYDGEFNAQAESTASQYYERAFVRVQYIVSILHGEIPEGEGVTVTTQEAGQI
                     DPVEEGTTEQQQQQQQQQQQ"
     CDS             complement(9600..10028)
                     /locus_tag="ctg80_8"
                     /transl_table=11
                     /translation="MANVNTFGLQVMSINGIFFDGRAASITLPCSDGELCIQSHHEEMW
                     VAIYAGEIKIRKPDGEVVTGVCGNGSVQFANNRCLVLADTIERPEDIDIRRAKEALEVA
                     KERMRQKNSIAEYKMSQAAMARALSRLKATNKRIGGLD"
     CDS             complement(10155..11543)
                     /locus_tag="ctg80_9"
                     /transl_table=11
                     /translation="VKDGRIVQVMGPVVDVEFQDSDLPHIDDALEVINNNKKVVMEVAQ
                     HIGDNTVRCIMLAASEGLSKDMTVHPTGAPIQVPVGDDTLGRLFNVTGQTIDNGPSLEH
                     GEHWSIHREAPPLSEQSPVVEILETGIKVIDLLAPYSKGGKVGLFGGAGVGKTVLIQEL
                     IQNVASEHGGYSIFTGVGERSREGNDLWSEMKESGVLSKTALVFGQMNEPPGARMRVAE
                     TGLTMAEYFRDVKNQDVLLFIDNIFRFIQAGSEVSSLLGRMPSAVGYQPTLATDLGSLQ
                     ERIASTKTGSVTSVQAVYVPADDLTDPAPATTFAHLDAQTVLSRKIVEQGIYPAVDPLE
                     SSSRILEADVVGERHYNIARKVTEMLQKYKELQDIIAILGMEELGEDDKQTVYRARKIQ
                     RFLSQPFHVAEQFTGVPGKYVSLEDTIKGFEAIVGGEMDQYPEVAFFNVGKIDDVVEKA
                     KSLE"
     CDS             complement(11562..12518)
                     /locus_tag="ctg80_10"
                     /transl_table=11
                     /translation="LADIKEIQDRIKSVNDTMKITNAMYMIASNKLRKARKMLEETEPY
                     FYAARGMLDRVMRHLPEDSNDPFLNQHKEKDPKEIKRGYIIITDDKGLAGAYNHNVLKI
                     AEEHLKEDGDNWKLYVIGEMGRQYFLRKNIPVEEEFHYTAQNPTLSRARWISSMVLDPY
                     LRGELEEINIIYTAMKNSLVCETHFEKLLPLERPKNNDEMMRMAGITTPLEEFLMLPSP
                     EAVLDNIVPSLVTGYIYGAMVEAFCSVQNSRMMAMDTANDNAKQMIHDLSIQYNRQRQA
                     RITQEITEIAAGARALKRAHELQAQMREATKQALIKQ"
     CDS             complement(12548..14341)
                     /locus_tag="ctg80_11"
                     /transl_table=11
                     /translation="MSNISGFGGSGSQYSTAVVRYAGEPPKQEQLDKIKKILCDRIGIS
                     DVTITTQLDPSIGGGFIIRCGNYEYDWSDKGRAEQLRNKLKNIRHNDTSPSKSVVSMLR
                     GHVDIFDLSIESREVGKVSWVGDGIAQVVGLDRAFYGEIVQFEDGTKGMVQDIRRDHVG
                     CILFGSDENITQSSQVMRTYKEAGVPVGDELIGRVVNALGEPLDGKPPISTTEYYPVER
                     PAPGIIDRQSVNEPMETGILSIDTMFPIGRGQRELIIGDRQTGKTSIATDTIMNQKGKN
                     VICIYVAIGQKASTVAHIINTLTQAGAMDYTVVVSSTAADTSPLQYIAPYAGTAIGEYF
                     MQQGRDVLIVYDDLSKHAVAYRALSLLLERSPGREAYPGDVFYLHSRLLERSSKLSPEN
                     GGGSMTALPIIETQAGDVSAYIPTNVISITDGQIFLESDLFFEGQRPAVNVGLSVSRVG
                     SAAQTKAMKKAAGSIRIDLAQYREMAVFTQFSSDLDETTKKQLNHGKVLMELLKQPLGH
                     PLAMYEQVITLVAANSGKLDKVEPSQVKSVQAKLLDWFEKNEKDVIAELTNGKELPDEL
                     RKEIEKSVDAFFEKNKNLISE"
     CDS             complement(14380..14886)
                     /locus_tag="ctg80_12"
                     /transl_table=11
                     /translation="MELLNINANVIYNIINLLILVVAFRIILFKKVDKILEQRRKDVDG
                     QLQDASDDRIKAADLKREYEEKLSIQEAEKDKVMSEAREKGYAQYNEIITNAHKEADTI
                     IEEARVHAKADAERERAKYLAELSDVVIDAAAKIAANSHTAEGDSSLYDAFIENAFDKG
                     TEKQD"
     CDS             complement(14916..15131)
                     /locus_tag="ctg80_13"
                     /transl_table=11
                     /translation="MNLTAIGAAIAAFTGIGAGIGIGIATAKAVDAVARQPEASGKIMT
                     LLILGGALAEATAIYGMIVALLIIFA"
ORIGIN
        1 ttcggtctta ttcatgagtt cctcagtcca tcgaaggaat gtaaggaatc ccattcggtc
       61 gttactaaac ttaaacactc ttctggatag ctcaaatccc ctccagtcaa acgctctaca
      121 gaaatgtgtc tgtgatccaa catcaacccc aacaatcaat gtatttgccg taacttgctt
      181 aagtctgtca ttctgtgtaa aattcatttt gagaaacctc cggttagcat aagatgtttt
      241 ttcatccgcc aagatgaaca cctttatctt acttagaggt ttctttttat tcaattggcg
      301 ttatttctga attacaggaa tgctccatcc tttttaatat gatcggctgt attaaaatat
      361 agtcgaaatg tcaatttata tctatcaaca cgggtaaata tcaacattta tagatatatc
      421 aaatatttat aaatactcgt aaagatattc ttttttataa cgcctgaact tatctatatc
      481 tctgatctta tacgtaatca ttgggtaaga tcataaatca ataagatctt tagtattatt
      541 catcgagata taccacgttc tcgattcctc ttccaagacc tgcaaggcct gtacgtgcaa
      601 gctctaagat agtgtatccg tcaaggagct taaggaatgc gtcgatcttg tcttgtccac
      661 ctgtgatctc gatgataaga ctttcattgg atacatctac gatattgcct ctgaatacgt
      721 tagcaatagc aatgatctgc tgtctctggt ctacgtctgc cttaaccttg acaagtgcaa
      781 gctctctgta aactgaatca ccaggcttaa gctcatgtat gtctcgtaca tcaacaagct
      841 ttgcaacctg cttctcaatc tgctcgagaa tgtcatcatc acctgaagca acgatggtga
      901 tccttgtgaa tctcgggtca gctgttgtac cagctgtgat actttcaatg ttatatcctc
      961 ttctggaaaa gagtccggat attctgctaa gggttcctga tgtgttatca acgagaagct
     1021 ggaacacctt tttatatgtc ttaacctcag tatctgccat attcctttac ctctttaaag
     1081 tgtgaaatat tatattgaat aatggtgaaa ttttgatccc caaacatcaa tttaggtcaa
     1141 ttatatccgt gcaattttaa tgcgtcaata tgaagaattt aatgacttta tcattacaaa
     1201 attaatatta tcgtattacc gtttactttg caacgtcgtc tcatgggtca ttgaccatgc
     1261 aatacattat cactttaaac cataaaagtc aagcttattt tgcagccttt gaacgactta
     1321 ttctatttct aaatgcccaa aaataaatga cagaaaaaaa taaacggaag aaaaaagctg
     1381 ccgttacgcc agttcgtaac gacagctttg tagattgcat tatataccgg cttattgcca
     1441 gtttttttac caataagatc taatgatcat tgattcacaa gttcttggtt ttaaaactca
     1501 agtgattcaa gaaggtgata atactgagca aggtactcag aattttcaat atcctctgat
     1561 atgaagatta cgataccgat tccagatccg cctgtttcaa ataccatgat atccatttcc
     1621 atatccgaac catcaacagg tcctcttacg ttctcagcgt atcctccgtt aacagtaccc
     1681 ttctttatat ctttctcatc ataagaaact ccatatgaat ctgcaacgta gataagaacg
     1741 ctatcaattc cctgtttgag ctgggaatct gtcaggcttg tagtatcaac ttctgagtac
     1801 attacgagaa taccggacat tgcattctta tcaggagcat aaatatatcc ggacatatca
     1861 tctgacatat ctacttcctg tccataccag tcttccggta cttcatatgt cagagctccg
     1921 tatgtatcag ttatatactt ggtcttgtca tcttctgtta catcatcatc tgtatcagta
     1981 aagtcgaaat cgcccatctc aaggagaccg ccaagataca gcatgaaact ggtgtatacg
     2041 ttaactgtct catcatcaag atcttcaaaa tcaggatcga tatctacgcc tgtatcaaac
     2101 tctacaaatg taagtgagta ctcaagctta tccattgtaa actcgatatc atctgcgcct
     2161 gtatatgttc ttaatgaatc ctgtaaaggc tcatcctgga tatcagtaaa ctctgtctca
     2221 accttcacaa gctgagcatc ctcttttgaa acataaatag ttactgtgca aagatcagta
     2281 tctccattgt aaatacctga aataggagaa aatacgccgc tgataccgcc ctgatcatag
     2341 gtatcttcgc tgacataaac gtagcactca acaccgtcaa ctttttctgt cttatcctga
     2401 agctcagcct tatagacatc ataatcataa aaacctaaga gctcagttac aacctcgctt
     2461 tcagatgcaa catatctttc gcctgtatca tattcaatac cggaaacata cgaacctgaa
     2521 atatcaccac ggaatactga gatctcctga tcaaattcaa ctccaaggat ctctcttgaa
     2581 acagtaccct ctgccaattc taaagcatca gcatcagagt tctttgcgtt tacatcataa
     2641 tctgtaacga tcttaaattc tgcagactca actacgtcac cggatacgcc ttcatcagga
     2701 gctgccattg tacattccat tacataagag aactctgttg tcatatcctt gacttttgaa
     2761 agattctcac aggcaagctc aagagcttct tctcctgaga tttcttcctc ttcaggttct
     2821 gtagttgctt ctgttgcagc atttgaactg tcatccttct tctcttcttc ctctgtagaa
     2881 gcggatgtag ctacatcgat cttcttgtcg tcatcatcat cttttttctt agccttatct
     2941 gcacttatga aatgataagc tgctgcagat cctccgataa caagaacaag gatcactgaa
     3001 actattgcag cgatgatacc ctttttgctc ttcttaggcg gctgaggctg ctgattcatc
     3061 gggccataag caccgtattg catgttggga ttctgagcac caaactgttg ggcaccatac
     3121 tgattattgt tgtaatactg gttattatca aactgaccac cgctgtactg gttattatca
     3181 aactgattaa actgcccgcc atactgatta gtattctgac cgccataaaa ctgaccatta
     3241 tcaggctggc tcataccctg accattacca agaggatcat atcctccaaa gctctgaccg
     3301 cccataccgg ttgcagcgtc attcattccc ccgttaattg catcattccc cttttgttct
     3361 ttactgatat ctgctccgca gaaaccacag aacttgcttc catccggaag ttcttttcca
     3421 caattaggac aaaacattac ttccctccat tctcattttc aacacatttc gtcaaggcca
     3481 gagttcctgt acgagccact tccacaatag agatccctct cagcatagaa agaagaagct
     3541 gtgaacgctc cgggacatcg cagatttgga tcatcatata ggatttagac atatccacga
     3601 tctgtgcctt catgatgtca cagttttcta ttatatcacg tctgttggat ttgttgtact
     3661 taacctttat gagcataagt tctctgctta tggatgcagg ctcatcgaag gttttgacct
     3721 tgatgatatc aagctttttg ttgagctgct tctcaacctg ctcaaggata gccttgtcgc
     3781 cgcttgatac aattgtcatt ctcgatacag tcggatcttc cgtctcacca actgtaagag
     3841 aatcaatgtt aaaagatctt cttgaaaaaa gacctgcaac ttttgaaaga acacctgttc
     3901 tgttttcaac aagaactgaa tatatctttt tcataagtaa tctccgtttt aacctttcgc
     3961 cagatccatc ggatcagtca taacttccag aaggacagcg tgctcgttat taaggaaatc
     4021 cttgatctcc ttatcaatgt cgctacctcc gtcaatcttc tgataatcca taccgtatgc
     4081 ctttgcgatc atatcaagtt caggtttacc tgcgatatca accattgcat acttatcttt
     4141 ataagaataa tgctgatatt cgcggaccat tccaaggtag ttgtttctat atacgattat
     4201 cttgagcgga accttctgct gatccatagt tgcaagctcc atcatagaca tctggaagcc
     4261 gccgtctccg caggatgcaa caacctgtct gtcagggtcc gcaagcttag cgccaagagc
     4321 cgcaggaata gcatatccca tggttcccat accaccactt gtcataaatc tctgatgctc
     4381 tttgatcctg aaaaacgctg ttgcccagat ctggttctgt cctacatctg caacgaatac
     4441 tccgttgtca tccatagctt tagcgagctt tccaaggaac tctttgggat caacatattc
     4501 ttttgatata tcaggtcttg gatcaggatg ccctgcttta taatccgtaa ggaattcaag
     4561 ccattcttta tgatcccttg catttatatc aattgtattg agctttgtga aaatatgttt
     4621 aagatcacca acaagcggaa tcgtaggtcc tacgttcttg cctatctcgg cgggatctac
     4681 atctatatga ataagaactg tattatctgt gataagttca ggtctgttga ctgctctgtc
     4741 tgcaacgcgg gcaccaacca taaggacaag atctgaatcc ttcagagctt tattggcata
     4801 agctcttccg ttattgccga ccatgccgaa ataaagagga ttgtcattag taatagtgcc
     4861 aagtcccatc attgtagata ctacaggtat ctggcactta gccgcaaaat cccttatctc
     4921 ctgcgccgca tcagaaaggt gaacgcctcc gccaacgcac attacaggct ttttggatct
     4981 ttctacttct ttgacaagct tcttgatctg agccatattg ccttcaacag tgggcttgta
     5041 ggttctcatg ctgactgttt caggataaga gaacttatta atctgagcct gctgtatatc
     5101 aataggaata tcaataagga caggtccttt tcttccggaa ttagctatat aaaaggcttc
     5161 cttgaagatc ttagggatgt cgttaacgtt tcttacaaga tagctgtatt taacaaaaga
     5221 ctctacagcg cctgtgatat cagcttcctg gaatacgtca gagcctatca tagagctgtt
     5281 aacctggcct gttatggcaa taagcgggat gctgtcagca aaggctgtag ctatgcctgt
     5341 tataaggtta gttgcacctg ggcctgatgt aacgacgcag acaccgggct taccgcttat
     5401 ccttgcatat ccgcttgcac agtgggcagc attctgctct gtacgtatga ggacggattt
     5461 aatatctgaa tttaataagc tgttaaaaaa tggagcgatc gcaactccgg gataaccgaa
     5521 gaggatctca acattttcct ttttcaaaca ctcaacaatc gcatctgcac ctatcatgta
     5581 ggggcctcct tatatttgta ttactttaat cctattatat atcaaaacaa ttgataatat
     5641 ttatctagtt aatactatat atcgtacaat tgtgtgtatt aataaataat atgttaaaaa
     5701 ttatgctgtc tgctccataa gttcattgac cactcgtacg cagtctgctg catcggtgga
     5761 gtagccgtct gcgtttattt ctttggcata gtcttctgtt acgcaggcgc cgccgatgat
     5821 gatcttggcg gtacagccac gctctttggc aagctggatt acatttttca tttcaaccat
     5881 tgttgtggtc atgagggcgc ttaatgctat tatctttgca ttttctttca tggccgtttc
     5941 tataatcagc tctgactcta cgtctttgcc aaggtcgata actctataac cgcagttgcc
     6001 aagcatcagc gctaccaggt ttttgccgat gtcgtggacg tcgccgtgga ctgtagcgat
     6061 aattacggtt cctttgggtt cgctctgctc tccgctttgt ttaaggagag gctcaaggac
     6121 tgcaattgag agtttcatgg cttcggcgct ggcgataagc tgaggaagga aataggttcc
     6181 tttatcaaac ttggcgccta cgtcgttgat tgcaggcatt aagacgtcgt ttaggatctt
     6241 agcgggttcg cagcctgcgt ctattgcggt ctgggtgttt tgggctattt ttcttttgtt
     6301 tccgcccatg acatctttat agagaatgtc catgttgcgc tgaattggat ctgaactttt
     6361 ctcatcagta ggtgttcctg tgccggatgc ggcattggaa gctgaacttc cggatatgct
     6421 tacggctatt ttgccggcgt ctccgtcata gcgctgcatt cttgtgatgt atctaaggtc
     6481 tgattcttcc ttgtgtttga gcaggtctga tgcaaatgcg gcgttgacga ggagttcctg
     6541 ggacggattt gagatcgcca ttgtaaggcc tctgtcgatc gccattgtaa gaaaggctgt
     6601 atttatgaag cttctctggg gcaagccaaa agagatattg gaaaggccac agattgttgc
     6661 atagccgttc tcatagcacc actggatagt ttcaagggtc ttgatggcag cttcagggtc
     6721 agcgccgact gttgctacaa ggccgtcaac tactatatct gatttggtaa gaccgtagga
     6781 aagagccata tcagtgagtt ctttgatgtt agcgatcttt tcttctatag tagtaggaat
     6841 tccgtctctg cctaccggaa gaaggatgaa cattgcgcca tatttttttg caagaggtag
     6901 acatcgttct gccttgcctt cttcgagtga tattgagtta atgagcgcac gtcccggata
     6961 ccagcgaagg gcttcttcca taacgtctac gttacttgaa tctatacata taggaagtga
     7021 tgtgagctga attacttcgt ttaagacttt catcatcatc tcatgctcgt cgattccgct
     7081 cattccgaca ttgacatcga gaatggcagc gccgtcctct tcctgcttgg tcgtgaagtc
     7141 gcagaccata tcaagggagc cttcacgaag ctgagcctga agtttctttt taccagtagg
     7201 attgattcgc tcgccgacga tcatgaatgg atcatttaag gaaaaagaaa gtaactctct
     7261 ttcagaagta aggcgtctta agctcttatc gcctcttgta aggggattac cctcttcgtc
     7321 gcgagcgctt gttgtatcaa aatcagtgaa tttatctttt aacgctttga taaaatcagg
     7381 tgttgaaccg cagcagccac caataatgct ggcgccgcta tttaataaaa gctccatgtc
     7441 atctgcaaat tcagatggct gcatgtcgta tatggtctgg ccgtctacaa cggaaggcat
     7501 tccggcgttg ggcttagcga ttatcggaat gtttgtaacc tgagccatac gtcttattac
     7561 agccgccatc ttgtcagggc ctgttgagca gttagcacca actgcgcagg cgccaaggga
     7621 ttcgagaact actgcagcgc actcgggagt tgttccgtat agtgtcttgc cgtcaccttc
     7681 gaacgtaagt gttaccatta caggaaggtc tgaaacttcc ttggcagcga tcattgctgc
     7741 tctgcattcc tgaaggctca tcattgtttc tactacgagg aggtctgctc ctgcctcgtc
     7801 tataactttg atctgttcct tatatacttc tatgagttct tcaaaagaaa ggtcgcctac
     7861 aggctggagt tggcggcctg tcattgtgat atcgcctgca acgagggctt tgccttctac
     7921 tgcttctttt gaaagtttaa taaggtctgt attcatctgg actagcttat cttctagtcc
     7981 gtattctttt aacttaattc ttgatgcggt gaatgttggt gcgtagacta tgttacttcc
     8041 tgcatttgca tatcttcttt gcagatctat catgacatcg cggtggttta agatccactc
     8101 ttcggggcat acgcctgcgg gcattcctgc tttcatgagg ttggtgccgg tggcaccgtc
     8161 taaaaaaatg gggtggttat ttttgaaaaa attttcgaaa tcttgcctgg tcaaaaaggg
     8221 cctcctataa aaacgcattt cactttactg cgttaattta cgatatttgt attatcctat
     8281 cacagacacc cgcaaactac aactcttcat ttggggggcg tggtagcgta gctgcgggac
     8341 tgaggaaata aagtcataag cctcagttga aaataatacg gatattccta agtgtcttat
     8401 ccgctttcgt ggacatgcta tactgcagct cctaagacac taaggaaaat ctgtattttt
     8461 tcaaaatcgg cttatgactt tatttcctca gtcccgccat ctacgttcac gcacgttgta
     8521 gttaatgagg gtgtttgcca agcgtaatta gatataaaaa gcaatacttg tgttgccctt
     8581 tttattatga cgtattagaa tatgttgata ggttttctta agtatatatg cagttttata
     8641 atatatgctt ttatcgagaa tataagcatt ttctagttat ttagctaatt atatattatg
     8701 acgtaagggt caaaagtcat ttcgattcga gcttgctcga aatcgaatat gaatttatga
     8761 cccgcaaaac atgagcaaag tagcacgtag tgcggatttg cgaatgtttt aggattgtga
     8821 gagtttcgaa gaaacggaac aatccgttag tcataaggtg tcaaaaggaa cttttgacac
     8881 ctacctcata ttattataag aaatacaacc tacaaataac aaaaatactt tttagcgtaa
     8941 ggggaatgag attttgaatt ttattaaaag gaatataact atattatcga tattattagt
     9001 ctccgttatt ggtttatgcg gatgtggtaa gaatagtgag cttgagtctt ataagactag
     9061 tatgaagact ttttttacag aggtttccga ttgtaatgat gctatgaaca gtattgatcc
     9121 taatgctgat gatgcaccgg cgcagctgct tacttatatt gataagttaa atgcaagttt
     9181 tgctactatg gcgacattgg aggttccgag tgaattcaag gctgcggagg ggctggctga
     9241 tgaggcggca gataatatgg ctaaggctgc gatttcttat catgaggctt atgatgggga
     9301 gtttaatgcc caggctgaat ctactgcgag ccagtactat gaaagagctt ttgtaagggt
     9361 tcagtatatt gtttctattc ttcatgggga gattccggag ggtgaaggtg ttactgtaac
     9421 tacgcaggaa gctggtcaga tcgatcctgt tgaagaagga acaactgaac aacaacaaca
     9481 acaacaacaa caacaacaac aataataaac agcaacaaaa atagtgacag aaaagcgagc
     9541 agcttatgat aactgctcgc ttttttatcc aataatttta ttttatttaa ctgctcgcct
     9601 tagtcaagtc cgccgattct cttgtttgtg gctttaagtc ttgaaagagc tcttgccatg
     9661 gcggcttggg acattttgta ttctgcgatg gagttcttct gacgcatacg ctctttggca
     9721 acttcaagag cttcttttgc tcttctgatg tcgatatctt caggtcgctc tatggtgtcg
     9781 gcaaggacga ggcatctgtt gttggcgaac tgaacagagc cgttgccgca tacgcctgtg
     9841 actacttcgc cgtcaggttt tctgatcttg atttcgccgg cgtagatggc aacccacatt
     9901 tcctcatgat gagactggat acacagttcg ccgtcgctac aaggcagggt gatactggca
     9961 gctcttccgt caaaaaatat tccgtttatt gacatgacct gaaggccaaa tgtattaaca
    10021 tttgccataa actactcctg gtaaatatcg tcttaatctg tttgacattt attctgacag
    10081 acttaaaact tttgtattag catcttgtca taagaatctg aaacagctaa gactatatat
    10141 ctattacatt ctttttattc aagtgattta gctttctcta ctacatcgtc gatcttacca
    10201 acgttgaaga atgctacttc cggatactga tccatttctc cgccgacaat agcttcgaag
    10261 ccttttattg tatcttcgag agaaacgtac ttgccgggaa cacctgtaaa ctgctcagct
    10321 acgtggaatg gctgagacaa gaatctctgt atcttacgtg ctctgtaaac tgtctgctta
    10381 tcatcttcgc caagttcttc cataccgagg atagcgatga tgtcctgaag ctctttatac
    10441 ttctgaagca tctcagttac tttgcgggcg atattgtagt gtctttcacc aacaacatct
    10501 gcttcaagga tacggcttga agattcaaga ggatcaacag ccggatagat accctgctct
    10561 acgatcttac gggacaaaac tgtctgcgca tcaaggtgag caaaggttgt agcaggtgca
    10621 gggtctgtaa ggtcatctgc aggtacgtat acagcctgaa ctgatgtaac agatcctgtc
    10681 ttggttgaag cgattcgctc ctgcaaggat ccaaggtcag ttgcaagtgt aggctgataa
    10741 cctacggctg aaggcatacg tccaaggagt gatgaaacct cagaaccagc ctgaataaat
    10801 ctgaaaatat tatcaatgaa aagaagtacg tcctgattct taacatcacg gaaatactca
    10861 gccattgtaa gtcctgtctc agcaacacgc atacgtgctc ccgggggctc attcatctgt
    10921 ccgaatacca gggctgtttt tgataaaaca cctgattctt tcatttcgga ccaaaggtcg
    10981 ttaccttcac ggcttctctc tccaactcct gtgaaaatag agtatccacc gtgctcggat
    11041 gctacgttct ggataagttc ctgtataagt acagtcttac caacgccggc accgccgaag
    11101 agtccgacct taccaccttt agaatatggc gcaaggaggt ctataacctt gatacctgtc
    11161 tcgagtatct caacaacagg gctctgctca gaaagtggcg gagcttctct gtgtatagac
    11221 cagtgctctc cgtgttccag agaaggccca ttatcaatgg tctgtcctgt aacattgaag
    11281 agtcttccaa gggtatcatc accaacaggt acctgaatag gagcccctgt aggatgaact
    11341 gtcatgtctt tggaaaggcc ttctgatgca gcaagcataa tacatcttac tgtattatcg
    11401 ccaatgtgct gggcaacttc cattacaact tttttgttat tgttgataac ttcaagagca
    11461 tcgtcgatat gtggcagatc agaatcctga aactcaacgt ctacaacagg acccatgacc
    11521 tgtactattc tgccatcttt cactttgcac ctcttttact attattgctt aattaatgcc
    11581 tgtttggttg cttctctcat ctgtgcctga agctcgtggg ctctttttaa ggctctggct
    11641 ccggctgcga tctcagttat ttcctgtgtg atcctcgcct gcctctgcct gttatactgg
    11701 atcgaaagat catgtatcat ctgcttggca ttgtcatttg cagtatccat agccatcata
    11761 cggctgttct gcaccgagca gaaagcttca accatagctc cgtatatata acctgttacc
    11821 agtgacggga ctatgttatc aagtaccgct tccggacttg gcagcatcaa gaactcttcc
    11881 aaaggagtcg taatacctgc cattctcatc atttcatcgt tgttcttagg tctttcaaga
    11941 ggaaggagct tttcgaaatg tgtctcacat acaaggctat tcttcatagc tgtgtagata
    12001 atgttaattt cttcgagttc tcctctaaga taaggatcaa gaaccattga agatatccat
    12061 cttgcacgtg acagagttgg attttgtgct gtatagtgga actcttcttc gacaggaata
    12121 ttttttctca aaaaatattg tctgcccatc tctcctatta cataaagctt ccagttatct
    12181 ccatcttctt taagatgttc ttctgcaatt tttaggacat tatgattata agctcccgca
    12241 agtcccttat cgtcagtgat gatgatgtag cctcttttga tctctttagg atccttttct
    12301 ttgtgctggt tgaggaatgg atcgttggaa tcttcgggaa gatgtctcat aactctgtcc
    12361 agcattcctc tggcagcata aaagtaaggc tctgtctctt caagcatttt tctggctttg
    12421 cggagcttat tggacgcaat catatacatt gcgttcgtga ttttcatggt gtcattgaca
    12481 cttttgattc tgtcctgaat ctcttttata tcagccaaat cattgcctca tttaaactaa
    12541 aaatttgtta ctcagaaata agattcttgt tcttttcaaa gaaagcgtca acagatttct
    12601 cgatttcttt tctcagttca tcaggaagct ctttgccgtt ggtaagttca gctattacat
    12661 ccttttcgtt cttctcaaac cagtcaagga gcttagcctg aacgctctta acctgagaag
    12721 gttcaacctt atcaagctta ccgctgttag ctgcaacaag tgtgataacc tgttcgtaca
    12781 ttgcaagcgg atgtccaagt ggctgtttca aaagttccat gagaacttta ccgtggttga
    12841 gctgtttctt ggttgtctca tcaagatctg aagaaaactg tgtgaaaaca gccatttctc
    12901 tgtactgggc aaggtcgata cggatagaac ctgcagcttt tttcatagct ttggtctgag
    12961 ccgcggaacc tacacgggat acagaaagac ctacgttaac agcgggtctc tggccttcaa
    13021 agaaaaggtc actttcaagg aatatctgac catccgtgat agagataacg ttggtcggaa
    13081 tgtaagcaga aacgtcaccc gcctgggttt caatgattgg aagtgctgtc attgaaccgc
    13141 cgccattctc gggtgaaagc ttacttgatc tttcaagaag tcttgagtga agatagaaaa
    13201 cgtctccggg atatgcttca cgtcctggtg atctttcaag aaggagtgac agcgctctat
    13261 aagcaactgc atgcttggaa agatcatcat aaacgataag gacatcgcgt ccctgctgca
    13321 tgaagtattc accgatcgca gtacctgcat atggtgcaat gtactgaaga ggagatgtat
    13381 cagctgcagt tgaggataca actactgtgt aatccatagc accggcctga gtcagtgtgt
    13441 ttatgatatg ggcaactgtt gatgccttct gacctatggc tacatagata cagataacat
    13501 ttttgccctt ctgattcatg atagtatctg ttgctataga tgtcttaccg gtctgtctgt
    13561 caccgatgat aagctcacgc tgaccacggc cgatagggaa cattgtatcg atagaaagga
    13621 tacctgtctc cataggctca ttaacagact gtctgtctat aattccggga gccggtctct
    13681 caaccggata atattccgtt gttgagattg gcggcttacc atcaaggggc tcaccaagag
    13741 cattgactac tcttcctata agttcatcac ctacaggaac accggcttct ttatatgtac
    13801 gcataacctg acttgactgg gttatgtttt catctgaacc aaaaagtata catccgacgt
    13861 ggtcacgtct tatatcctgt accattcctt tggtaccatc ttcaaactgg acgatctcac
    13921 catagaaggc tctgtcgagt cctactacct gggcgatacc atcaccaacc catgatactt
    13981 taccaacttc tctactttcg atagagaggt caaaaatatc tacatggcca cgaagcatag
    14041 aaacaacgct ttttgaagga ctggtatcat tgtgtcttat attcttaagc ttgttacgaa
    14101 gctgctcagc tcttccttta tcgctccagt catattcata attgccgcag cgaataataa
    14161 atccaccacc aatagatgga tccaactgag ttgtgatcgt gacatcactt ataccaattc
    14221 tgtcacaaag tatttttttg atcttatcaa gttgttcctg ttttggtggt tctccggcat
    14281 atcttacgac tgcagttgaa tactgcgagc cggatccgcc aaatccacta atattactca
    14341 ttcagtctcc ttagggccat ctactggcca aaagttaaat taatcctgtt tttctgtgcc
    14401 cttatcaaat gcattttcaa tgaatgcatc ataaagactg ctgtcgcctt ctgctgtatg
    14461 tgaatttgca gcgatcttgg cagcggcatc gattacaaca tcactaagtt cagccagata
    14521 tttagcacgt tcacgctcgg catcagcctt agcatgtact ctggcttctt caatgattgt
    14581 atctgcttct ttgtgggcgt tggttatgat ctcattgtac tgagcatagc ctttttcacg
    14641 ggcttcactc ataaccttat ccttctcagc ttcctgaata gagagctttt cttcatactc
    14701 tctcttaaga tcagcagctt tgatcctgtc atctgacgca tcctgaagtt gtccgtcaac
    14761 atcttttctt ctctgttcaa ggatcttatc aaccttttta aaaagaatta tacggaaagc
    14821 aacaaccagt ataagcagat ttattatgtt gtatataaca ttcgcgttaa tgtttaatag
    14881 ttccattttc gcgcttcctt tcccgtcccc tattcttatg caaatatgat cagaagagct
    14941 acgatcatac cataaatagc tgttgcttct gcgagagctc cgcccaggat aagaagtgtc
    15001 atgatcttac cacttgcctc aggctgacgt gctactgcat caacggcttt agcagttgca
    15061 ataccaatac cgatacctgc gccaattcct gtgaatgctg ctattgctgc tccgattgct
    15121 gttaagttca tactataatc tcctttcgtc aaaagtcgtt tttatgcgac tcaataacta
    15181 ccatattttg tttttacaat gcgatcagca tttatgatga tcgcacctta ttaagttttt
    15241 attactgtgg gagttaaaaa tgtctatgac atttttaact cttagcgatc aatattggaa
    15301 atattgatcg ccttattctg ttgcttcttt gatatacaaa cttgtcagga atataaatac
    15361 atatgcctga agaagtccat caaacaagtc aaaataaact gataaaatag cgggtgcaat
    15421 gacaggaacc atcttcttca aaagttccat aatgatggtc gcaccaagaa cattaccaaa
    15481 aagacgcatg caaagtgata atggtctgat tccaacctca agaatgttca ttggggtaat
    15541 gatagcaacc ggctgagcga aagacttaag ccagcct
//
