LOCUS       c00018_NZ_JACI..       16533 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_JACICA010000018.1 Alloprevotella rava strain DSM 22548
            Ga0373290_18, whole genome shotgun sequence.
ACCESSION   c00018_NZ_JACI..
VERSION     c00018_NZ_JACI..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 00:51:35
            Original ID  :: NZ_JACICA010000018.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 5043
            Orig. end    :: 21576
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16533
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[15043:19450]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [Aminotran_5, GCV_H, GCV_T,
                     GDC-P, SoxG]) and GCV_H and GCV_T_C)"
                     /neighbourhood="10000"
                     /product="Glycine_cleavage"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14407
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [Aminotran_5, GCV_H, GCV_T,
                     GDC-P, SoxG]) and GCV_H and GCV_T_C)"
                     /neighbourhood="10000"
                     /product="Glycine_cleavage"
                     /protocluster_number="1"
     cand_cluster    1..16533
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [Aminotran_5, GCV_H, GCV_T,
                     GDC-P, SoxG]) and GCV_H and GCV_T_C)"
                     /kind="single"
                     /product="Glycine_cleavage"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16533
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Glycine_cleavage"
                     /region_number="1"
                     /rules="(minimum(2, [Aminotran_5, GCV_H, GCV_T, GDC-P,
                     SoxG]) and GCV_H and GCV_T_C)"
                     /tool="gutsmash"
     CDS             1049..1528
                     /locus_tag="ctg18_4"
                     /transl_table=11
                     /translation="MVKIRVGFGYDVHQLVEGRKLWLGGISIENPKGLLGHSDADVLIH
                     AICDALLGAANLRDIGYHFPDTATEYKNVDSKILLRRTTDLLHKAGWNIGNIDATICAE
                     YPKLNPHIEKMKETLASLMEIEVSEVSLKATTTEKLGFTGREEGISTYAVALIEK"
     CDS             complement(1602..2993)
                     /locus_tag="ctg18_5"
                     /transl_table=11
                     /translation="MKRTKIIDVLKRTDFGAEVLVKGWVRTRRGSKSVSFIALNDGSTI
                     KNVQIVADNEKFDEDLLKDITTGACISVTGTLVESQGSGQAVEVQATQIELLGTCPADY
                     PMQKKGQSFEYMRKYAHLRLRTNTFGAVFRIRHNMAMAIHRYFHEHGFCYFNTPIITAS
                     DAEGAGEMFQVTTLDLARTGKEEKVPYDRDFFGKKASLTVSGQLEGELGATALGAIYTF
                     GPTFRAENSNTPRHLAEFWMIEPEVAFMDQTELMDLEEDFIKYCVQWALDYCMDDLEFL
                     NKMIDKNLIATLQSVVKEDFVRLTYAEGLQILEEAVKKGQKFEFPITGWGMDLSSEHER
                     YLVEIHFQRPVIMTNYPSEIKAFYMKKNEDGKTMQGTDVLFPRIGEIIGGSVREENYEK
                     LVGEIEVRGMEEKDYGWYLDTRKYGSCPHAGFGLGFERLILFVTGMQNIRDVIPFPRTP
                     KSAEF"
     CDS             complement(3002..4357)
                     /locus_tag="ctg18_6"
                     /transl_table=11
                     /translation="MSDLENNFYQDGGHRDDFQPSSNKSNAFQQRSSRPRFNRNQRVGG
                     YSSSAGQNRQGYRPRFNQNREDYQPNNRYNEEERGEQGFRPRYNRDNGYQPRSNNYNRQ
                     GSYNRQQGEYRPRYSQQGEGGYQPRQYNQDYGNEGQGNYQHRSSGYDRQNNGYVRQSNG
                     YNRQGNSYDRQQRGGFNRSRQQRSSSGYDPHAKYSHKKRIEYKEKNIDPNEPIRLNKYL
                     ANAGICSRRDADKYIEAGVITVNGEVVTELGTKVLRTDTVLFHDAPVKIEHKVYILLNK
                     PKGYVTTSEDPQNRKTVMDLVRGACPERIYPVGRLDRNTTGVLLLTNDGEMAAKLTHPQ
                     FMKKKIYHVYLDQNVSAADMRQIAEGITLEDGEIKADEIQYASDTDKKQVGIEIHSGKN
                     RIVRRIFESLGYHVNKLDRVFFAGLTKKHLKRGDWRFLTEEEVNFLRMGSFE"
     CDS             complement(4404..5792)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lyase_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_7"
                     /sec_met_domain="Lyase_1 (E-value: 1.4e-52, bitscore:
                     169.2, seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LRAVYTFFYINHMNLDALTAVSPIDGRYHQKTVSLAPYFSEQALM
                     KYRICVEIEYFIALCELPLPQLQHLDSSLFPRFRSIYENFSEVDGQRVKDIEAVTNHDV
                     KAIEYFIKEKLDEIGDCDTYKEFIHFGLTSQDINNTSFPMMLKESLKDVYLPLVDELIQ
                     QLNAYVEDWKDIPMLAKTHGQPASPTRLGKEIHVFSYRLEQARVQLDKAVQEISGKFGG
                     ATGNFNAHHVAFPQYNWTEFANNFLEKSLNIQRELFTTQISNYDNFGQVFDAMKRLQTI
                     VMDLDRDIWQYISMGYFKQKIKKGEVGSSAMPHKVNPIDFENSEGNIGLSNAILEFLSR
                     KLPISRLQRDLTDSTVIRNIGVPMGHGVIALQSTLKGLRKLVLHKENIDADLDNCWPVV
                     AEAIQTILRREAYPNPYEALKALTRTNEAVTAETILEFVEGLDISEDVKAELRAITPHN
                     YTGL"
     CDS             complement(6374..6709)
                     /locus_tag="ctg18_8"
                     /transl_table=11
                     /translation="VYYIFNGNNSTNSSENGTFYISTLGSTQNIDNFHLIQLECKNGQR
                     WYKYVKVVGFGKVKEEPVGIPVVTTELKHGIYKLTPALPLSRGCYGLFYNYSNGVPTEI
                     YDFDVLF"
     CDS             complement(6693..6935)
                     /locus_tag="ctg18_9"
                     /transl_table=11
                     /translation="LQQTKFEIMKERIFLVYLLAFFISVIGMAQTSRDAQAAAKIYAYG
                     VYYFNANGKLIRMQPLKNAGMKQKGILRPKSVLYF"
     CDS             7056..8822
                     /locus_tag="ctg18_10"
                     /transl_table=11
                     /translation="MYRTNTCGELRIKNVGQKVTLTGWVQRTRKMGGMTFVDLRDRYGI
                     TQLVFNNETNATLCDRANKLGREYVIQIEGLVSERFSKNDKMPTGEIEILVDMLDVLNE
                     SLTPPFTIEDNTDGGDDLRLKYRYLDIRRDAVRSNLELRHKMTLEVRRYLDSQGFLEVE
                     TPALIGSTPEGARDFIVPSRMNPGQFYALPQSPQTLKQLLMVGGVDRYFQIVKCFRDED
                     LRADRQPEFTQIDCEMSFVEQDDIINTFEGMAKYLFKTVRGVELGNEPFLRLPWIEAMK
                     RFGSDKPDMRFGMEFVELMDILKGSGEFSVFNEAEYVGGICVPGCADYTRKQLDELTNF
                     VKSPQIGAKGLVYAKVNEDGTIKSSVDKFYSVDVLQKLQEAMGANPNDLILILSGLNAM
                     KTRKQLCELRLLMGERLGLRDHNKFALLWVVDFPMFEWSEEEQRLMAMHHPFTSPKPSD
                     IALLDTAPEKACADAYDMVCNGIEVGGGSIRIYDAKLQAKIFEVLGFTPEKAQEQFGFL
                     INAFKYGAPPHGGLAYGLDRWVSIFAGLDSIRDCIAFPKNNSGRDVMLDAPTAVDPKQL
                     DELFIKLDLKQI"
     CDS             8961..9971
                     /locus_tag="ctg18_11"
                     /transl_table=11
                     /translation="MSEKSKHFPACHVVFPPNCEERRAAFYLAAEEYVAETFNEDNYIF
                     TWQLSPTCVFGRNQIPHSELDVDFCNKNGIDLCRRKSGGGTIFADRNNIMISLITPACD
                     VESLFAEYAETVSAGLRKLGAPTKVSGRNDIILEDGRKVCGNAFYHQANRNIVHGTMLY
                     GTDVEKMIGALTPDKAKLESKGVISVKSRIGELKEYLPFDVTTLRSRLIAMLTNKSLEL
                     SEKDIKSIEDLEQTYYAPTYLWGHKAKSDICRTERIEQCGTVQVNITLRGSLIDSITLS
                     GDFFEIGKNVKDAFYNLFHEIPYNRAELKHILDLHHPEKLIRNLSEDELLNLLCP"
     CDS             10001..11089
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Glycine_cleavage: GCV_T"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Glycine_cleavage: GCV_T_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_12"
                     /sec_met_domain="GCV_T (E-value: 5.6e-89, bitscore: 288.1,
                     seeds: 72, tool: rule-based-clusters)"
                     /sec_met_domain="GCV_T_C (E-value: 2.1e-18, bitscore: 56.4,
                     seeds: 348, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKITCLHDKHVALGANMVPFGGFDMPLYYDNIVAEHEAVRQKVG
                     VFDVSHMGEVKVTGIEAEKFVQYIFTNDIKDAEIGKIFYGMMLHENGGTIDDLLVYKMG
                     EQDFLLVINAANIEKDYAHIVQYAKDFNVKTENLSDIYGQVAIQGPESEITVENVLGIK
                     CSDLTFYTFKTIHFEDEEIIISRTGYTGEDGFEIYASHTIIQFIWDKLIEAGIQPCGLG
                     CRDTLRFEVGLPLYGDELSDEISPIMSGLSMFVKLEKDNFLGKEACVDQKENKTYKQRV
                     IGIELQEKGIPRNGYPVQAEGKDIGYVTTGYKSISTGKFICMALIDKNYAKLETPVDVL
                     IHNKPRKGIVVKKRFYQKNYKK"
     CDS             11126..11503
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Glycine_cleavage: GCV_H"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_13"
                     /sec_met_domain="GCV_H (E-value: 1.7e-46, bitscore: 147.4,
                     seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKIIEGLYYSESHEFVKVEGEYAYIGITDFAQEQLGNVTYIEFP
                     EIDEEISAGDSFGSVESVKAASDLTSPVSGVVVEVNEVLEDEPELVNKDAYSNWLIKVK
                     LSDPSELESLMDAQAYTDICK"
     CDS             11580..12902
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Glycine_cleavage: Aminotran_5"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Glycine_cleavage: GDC-P"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_14"
                     /sec_met_domain="Aminotran_5 (E-value: 4.8e-11, bitscore:
                     32.4, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="GDC-P (E-value: 2.4e-137, bitscore: 448.4,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYKYFPHTEEEIQEMLKTIGVNSLEELYAEIPEELKVKQELNITS
                     AKSEMEVRKKLQDLAEANITPICFAGAGAYDHYQPSIIPYIASRSEFSTSYTPYQAEIS
                     QGTLAYIFEYQTMMARLTGMEVSNASMYDGATATAEAMMMCIHAARKKNTVLISDTFAP
                     NTLRVVETYANFHNVNLERIPAIHGVTDKEFLAKRLQEEEVAGIIVAQPNYYGVIEDFD
                     GYAELCHSHKALFVINSMASALGVLKTPGEWGADIACGDAQSLGFPLNFGGPYIGYLCT
                     KKEHVRKMPGRLVGATTDANGQRCFVLTLQAREQHIRREKATSNICTAQGVMCLYVAIY
                     LSLMGEKGLREVNEQSYAGAHYLHDKLLKTGKFKQVYDKPFLNEFCLRYKGNVDKFIRE
                     SIEKHHIFPGVKIENSENDILIAVTEKRSKEEIDQYIQLIK"
     CDS             12917..14407
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Glycine_cleavage: Aminotran_5"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Glycine_cleavage: GDC-P"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_15"
                     /sec_met_domain="Aminotran_5 (E-value: 1.3e-08, bitscore:
                     24.3, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="GDC-P (E-value: 2.6e-10, bitscore: 29.9,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNVYYGNLIFEISKAGRVGYSLPKSKIEGYKTAELPSTLLRSNK
                     VELPEADELTVVRHYTNASNNNFGVDTGFYPLGSCTMKYNPKINEEVAALPGFTQIHPL
                     QPVETAQGVLKLYDEEQKTLSEITGMSRFTLNPFAGAHGELTGLMTIRTYHTRRGDTKR
                     TKIIVPDSAHGTNPASAAVCGMQIVEVKSTPEGTVDVEDLKPLLGDDIAGMMMTNPNTL
                     GIFETSIPEIARLVHECGGLMYYDGANFNPMLGVCRPGDMGFDVVHLNLHKTFSTPHGG
                     GGPGAGPVGVRKDLEDYLPNPQVYQKDDGSYSVRVDAEALGSISSFFGNFGILVRSYAY
                     LLSLGKENIAMAGKLAVLNANYIKECLKSHYELPIKGLCKHEFVFNGMKEEYSGKHEDP
                     THVTTLDIAKRLLDYGFHAPTIYFPLLFHEAIMIEPTETESKNTLDNFIQAMKQIAEEA
                     KADKQLLKTAPHRTPIKRLDDVKAVKAAIFRFEDLDKE"
     CDS             14412..15749
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_dim"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_16"
                     /sec_met_domain="Pyr_redox_2 (E-value: 9.4e-71, bitscore:
                     228.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="Pyr_redox_dim (E-value: 2.6e-32, bitscore:
                     101.7, seeds: 83, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METKDLIIIGTGPGGYDVAVKAAKAGLQVAIFEKLHYGGTCLNVG
                     CIPTKTLCKNAELLEEIKAAEDFGIDIKESSLDMSRVIARKNGIVEKLSGAIEALMKTP
                     GITFVKGDAKFIDAHTIGAENQVFTAPNIIIATGSTTKFLPIEGAHSKGVVTSTEMLNL
                     EYVPKRLCVIGGGVIGLEFASIFNAFGSQVTVIEFCKEILPPFDRDIAKRLRTILKKKG
                     IDFKIGSAVVGIQEADDAYLVEFEEKGEKKCVTSDLVLMAVGREANLSSLNLDDVGIHY
                     TKKGIEVDEFMQTNVPGIYAVGDINGRMQLAHAATFQSYVALDHILGVKSQIHLQVCPA
                     VVFTSPEVAMIGKTEEELKSAKINYEVHKSMYRANGKALTMGCDEGLVKVLTDMGGHIL
                     GAHILGAHAADLIHEFALVMNESLKIDTLRNTIHAHPSLSEIIMKI"
     CDS             15954..16106
                     /locus_tag="ctg18_17"
                     /transl_table=11
                     /translation="LCANSRIISSKKQLQIATFTQRKYDKVMSEKVCKILLVLTLMLGV
                     PQASG"
     CDS             complement(16135..16431)
                     /locus_tag="ctg18_18"
                     /transl_table=11
                     /translation="LRTFAQRWGKKYPSLARLGNERNAAYFTYLRFSDSVRRMIYSTNW
                     VERLNRSYKRTLLMRGAMPSPTSVVYLLGSVAKEKTEGTYARRLPYFREWKIR"
ORIGIN
        1 gatgcccgtg ctggtggtat gggtgacatt ggtgctgcta ccgaaccaga tgttaatgca
       61 cagcaatgga atcctgcaaa atatcccttt acaattagta gagctggagt ttctcttaac
      121 tatacgccgt ggctgcgtaa gattacaaca ggcatagctc tcttgaatgc aacaggctat
      181 attcgtctag gagactatca ggcattgagt acttctgtgc gttacttctc attgggtgat
      241 ttttctgtag caaatgacaa cgcaatgact gtaaaacctt atgagtttgg aattgacatg
      301 gcctatagta gaatgttgag tgataacctc tctgctgctg tagctcttcg atacatgtac
      361 tctgacttga gcggtcacta tgatgacaat acaaaagcgg gatcagcctt tgctgctgac
      421 atagcaatgt attggaacaa atatgtgatg ctgggaagcc gtgagagtca acttgccttt
      481 ggtgtcaacg ttagtaacat tggttcaaag ataaattacg ggggcgatta ttcatacttc
      541 attcctacaa atttgcgtat aggtgggagc ttgatgatac cactcaatga atacaatcgc
      601 atctcattta gtgctgatgc aaacaaattg ctagttcctt cgatgccgct tagaaatgca
      661 gatgagagca atgaagatta taacgagcgt gtacgtgaaa agtactatga catgagttcc
      721 ataaagggta ttttcaaaag ttttagcgat gcgcccgatg gttttaaggg agaactcaaa
      781 gaaatcaatt ggggagtcgg agttgaatat acttacaatg ataaattcac tctccgtgga
      841 ggttaccaca atgaaaatgt ctcacaaggc gggcgtagtt tcttttcagt tggtgcaggt
      901 ttccgtatga atgtactatc tattgatgca ggttacgtag ttgcaaccag tgcgtctaat
      961 cctctcgacc aaacattccg agtaggtttg agttttgata tggatggtat caaagattta
     1021 tttggacgca gaagataaac attttattat ggttaagata agagttggtt ttggttatga
     1081 cgtccatcaa ttagtagaag gacgcaagtt atggttggga ggtatctcta tagaaaatcc
     1141 caaaggttta ttaggacata gtgatgcaga tgtactcata catgcaatat gcgacgctct
     1201 acttggagct gctaatctcc gcgatatagg ctaccatttt cctgatactg ctacagaata
     1261 caaaaatgtt gatagcaaaa ttcttcttag gagaacaaca gatcttctgc acaaggctgg
     1321 ctggaacatt ggcaatatag atgcaactat ttgtgccgaa tatccaaaac ttaatcccca
     1381 cattgagaaa atgaaagaaa cattggcatc cttgatggag atcgaagttt cagaggtttc
     1441 tttaaaagca acaactactg aaaagctagg ctttacagga cgtgaagagg gcatatctac
     1501 ttacgctgtt gcacttattg agaagtaaaa atacaaagca caataaaagg gactttcaga
     1561 tgaaagtccc ttttattata atctaagccc aaagctagat tttaaaattc agcagattta
     1621 ggagttcttg ggaaaggaat aacatcacga atattctgca ttcctgtaac gaacagaatt
     1681 aagcgctcaa aaccaaggcc aaatcctgcg tgagggcaag aaccatactt gcgagtatct
     1741 agataccagc catagtcttt ctcttccatt ccacgtactt ctatttcacc aacaagtttt
     1801 tcataattct cttcacgaac agaaccaccg atgatttcac ctatgcgcgg gaaaagaaca
     1861 tctgtccctt gcatagtctt tccatcttcg ttcttcttca tatagaaggc cttaatctcg
     1921 ctaggatagt ttgtcataat cacagggcgt tggaaatgaa tttcaacaag ataacgttca
     1981 tgctcgctgc ttaaatccat tccccaacca gtaattggga actcaaactt ctgccctttt
     2041 tttactgcct cctccaaaat ctgaagtcct tcagcataag taagacgcac aaagtcttcc
     2101 ttcacaacag actgcaaagt tgcaataaga ttcttatcaa tcatcttatt gaggaattct
     2161 aaatcatcca tacagtagtc aagagcccat tgtacacagt atttaatgaa atcttcttca
     2221 agatccatca actctgtctg atccataaaa gctacttcag gctcaatcat ccagaactct
     2281 gctaaatggc ggggagtatt actattttct gcacggaaag tagggccaaa ggtatagata
     2341 gcacctaaag ccgtagctcc aagttctcct tctaattgtc cactaacagt taagctagct
     2401 ttcttgccaa agaaatcacg atcataagga actttctctt cctttcctgt acgtgccaag
     2461 tctaatgttg ttacttggaa catttcgcca gcgccttcag cgtcactagc cgtaattatt
     2521 ggagtattga aatagcagaa tccatgctca tgaaaatacc ggtgaatagc catcgccata
     2581 ttgtgacgaa tacggaagac agcaccaaag gtattcgtac gaagacgaag atgagcatat
     2641 ttacgcatat actcaaagct ttgacctttt ttctgcatag gatagtcagc agggcaagta
     2701 cctaagagtt ctatctgtgt tgcttgaact tccacagcct gaccagagcc ttgactttca
     2761 actaatgttc ctgttacact aatgcaagca cctgttgtta tatctttgag aaggtcctca
     2821 tcaaactttt cgttatcggc tactatttgt acattcttaa ttgtactgcc atcattaaga
     2881 gcgataaagc ttacactttt gctgccacgt cgagtgcgaa cccagccttt aacaagtact
     2941 tcagcaccaa aatctgtgcg cttcagtaca tcaattattt ttgtacgttt catattatca
     3001 attattcaaa tgaccccata cgaaggaaat tcacctcctc ctctgtgagg aaacgccaat
     3061 cccctctttt tagatgcttc ttagtaagac ctgcgaagaa tacgcgatct agtttgttaa
     3121 catgatagcc caaactttca aaaattcggc ggacaatacg attctttcca ctatgaatct
     3181 caataccgac ttgcttctta tctgtatcgc tagcatattg gatttcatca gctttgattt
     3241 caccatcctc aagtgtaatg ccttctgcta tttggcgcat atctgcagca gaaacatttt
     3301 gatcaagata tacatgatat atctttttct tcatgaactg gggatgtgtg agctttgcag
     3361 ccatttcacc atcatttgtc aaaagcaaca caccggttgt attacggtct agacggccaa
     3421 caggataaat acgctcagga cacgcaccgc gaacaagatc cattactgtc ttacgattct
     3481 gtggatcttc acttgttgtc acatagcctt tgggcttatt gagaagaata tataccttat
     3541 gctcaatctt tacaggggca tcatggaaga gaactgtatc tgtacgtagc acctttgttc
     3601 caagttctgt tacaacttcg ccattaactg tgataacgcc tgcttctata tatttgtctg
     3661 catctcgacg tgagcaaata cctgcatttg caagatactt attcaaacgt attggctcat
     3721 tcggatcaat attcttctcc ttatattcaa tacgtttttt gtggctatac tttgcatgtg
     3781 gatcataacc actcgatgaa cgttgctggc gtgaacgatt gaagccacca cgttgttgac
     3841 gatcgtaact atttccttga cggttataac cattgctttg gcgcacataa ccattatttt
     3901 gacgatcata gccgctagaa cgatgttgat aattaccttg accttcatta ccatagtctt
     3961 ggttatactg gcgtggctgg tagccacctt caccttgttg tgaatagcga ggacgatact
     4021 cgccttgctg acgattgtat gagccttgac gattataatt gttggaacgc ggctgataac
     4081 cattatcacg attataccgc ggacgaaaac cttgttcgcc tctttcctct tcattatatc
     4141 gattgttcgg ttgatagtct tccctattct gattaaagcg aggacgatag ccttggcgat
     4201 tttgtcctgc acttgaagag taacctccta ctcgctgatt tcgattaaaa cggggacgag
     4261 aagaacgctg ctgaaaagcg ttggatttgt tacttgacgg ctggaaatca tcacgatggc
     4321 ctccgtcctg ataaaaattg ttttctaaat cactcattgt tattaagtta tattagcctc
     4381 gcggctattt tgtagttagt agtttataaa cctgtgtaat tatgtggtgt aatggcgcgt
     4441 agttctgctt ttacatcttc gctaatatct agcccttcaa caaactcaag tattgtttca
     4501 gcagtaaccg cctcattggt tcttgttagt gccttcaggg cttcataggg attaggataa
     4561 gcctctctgc gcaagatggt ttgaatagcc tctgcaacaa ctggccaaca attgtccaaa
     4621 tctgcatcaa tattctcttt atgtaaaaca agttttcgca aacccttaag agtactttga
     4681 agagctataa ctccatgccc cataggaaca cctatattac gtataaccgt tgaatccgtc
     4741 aaatcacgct gcaacctact gatgggcaat ttccgactca agaattctag aatagcattg
     4801 gacaaaccaa tattaccttc tgaattctca aaatcaatgg gattcacttt atgaggcatt
     4861 gcacttgatc caacttcgcc cttctttatt ttctgcttga aatagcccat agaaatgtac
     4921 tgccagatat ctctatccag gtccattact atagtttgca aacgcttcat agcatcaaag
     4981 acctgtccga agttgtcata gttcgaaatc tgcgttgtaa acagttcgcg ctgaatattc
     5041 agacttttct caagaaagtt attagcaaac tcagtccaat tatactgagg gaaagccacg
     5101 tgatgtgcat tgaaatttcc tgttgcacca ccaaacttac cacttatttc ttgtacagct
     5161 ttatctaatt gtactctagc ttgttctagt ctgtaactaa acacatgaat ttccttgcca
     5221 agacgcgtag gactagctgg ttgtccatga gtttttgcca acatagggat atctttccaa
     5281 tcctcaacgt aggcattcaa ctgctgaata agttcatcaa caagaggcag atacacgtcc
     5341 ttcaaacttt ccttcaacat cattggaaat gatgtattat tgatgtcttg gctagtcaaa
     5401 ccaaaatgaa taaactcttt gtaagtgtca caatcaccta tttcgtcgag tttttccttg
     5461 ataaagtact ctatagcctt aacatcatga ttggtcactg cttctatatc tttcacacgt
     5521 tgtccatcta cttcagaaaa gttctcgtag atactacgaa agcgtgggaa caaactacta
     5581 tcaagatgct gcaactgcgg taatggtagt tcacaaaggg caataaagta ttcaatttca
     5641 acgcaaattc ggtacttcat caacgcttgt tccgaaaaat acggggccaa actaactgtt
     5701 ttctgatgat atctgccgtc aattggcgat acggctgtta gtgcatccaa attcatgtgg
     5761 tttatataaa agaaagtata tacagcgcgc aaatttagcg atttaatttc gaataagata
     5821 ttatataggc aagatacttt tcaaaaaaga agccacaaaa agagcccttt attgaaaaga
     5881 agttgcaaat aattttacat tattactcta aaatacccat actcagataa cgctcgtctg
     5941 tatctggaag taaggctacg atcatttttc ctgcattctc ttcctgcttt gccaaagcca
     6001 gtgttgcaag aaatctggta ccactactaa tatgcatatt ctcctaaata tccttattgt
     6061 attttcaaac actataagga tgtcagctca cacaataagg acattttcaa acgcaataag
     6121 gatatttctt cacctcccta gataagtccg ctattttcac tctgaataac aagaaacttt
     6181 tcctcctaaa aaacaaatcc acaatactag agaaatagta ttgcggagaa aatattaaaa
     6241 gtataaaaag agaagcttga tcaacaataa tattattggc ttttttttcg cctaaattct
     6301 ataacagata ataaagttgc gatatagaat gcttagttca atcaaaattg agtctatcat
     6361 ctctgcagcg ctcctaaaat aggacatcaa aatcataaat ttcagtagga acaccattac
     6421 tataattata gaaaagacca taacagcctc tagataatgg cagagcagga gtcagcttat
     6481 aaatgccgtg cttcaattca gtagtaacaa ctggaattcc aacaggttct tctttcactt
     6541 taccgaagcc cacgactttc acatatttgt accagcgttg tccgttcttg cactccagct
     6601 gaatcaagtg gaagttgtca atgttttggg tgctccctaa tgttgagata tagaaagtcc
     6661 cattttcact agaattcgtt gagttatttc cgttaaaaat ataatacact tttaggacga
     6721 agtattccct tttgcttcat acctgcattt ttcaatggct gcatacgaat gagtttgcca
     6781 ttagcattaa aatagtacac accataagca tatattttag ccgcagcttg cgcgtcacga
     6841 cttgtttgtg ccatgccgat aacagatata aagaatgcaa gaagatagac caagaaaatt
     6901 ctttctttca taatttcaaa ttttgtttgt tgcaaaagta ataaattaga acgtgactta
     6961 gtagtttcgc gctcaagaaa ataatttgat tgctacttct tttcaccttt taattgtatt
     7021 tttgcacgaa ataaaaaatc aaaatataaa taacgatgta tagaactaac acatgcggtg
     7081 agttacgcat taagaatgtt ggtcaaaaag ttactttgac tggctgggta cagagaactc
     7141 gcaaaatggg aggtatgacg ttcgttgatc tgcgtgatcg ttatggcatt acccagcttg
     7201 tttttaacaa tgaaaccaac gctacactat gtgaccgcgc taataagtta ggacgtgaat
     7261 atgttatcca gatagaaggc cttgtaagcg aacgcttttc taagaatgac aagatgccaa
     7321 caggagaaat agaaattctc gtcgacatgc tcgatgtcct caatgaatct cttactccgc
     7381 cctttactat agaggataac acagatggtg gcgacgacct ccgcttgaag tatcgctatc
     7441 tagatatcag acgtgatgct gttcgcagca atttggaact tcgccacaaa atgacacttg
     7501 aagttcgtcg ctatcttgac tcacaaggct tcttggaagt tgaaactcct gctctcattg
     7561 gttccactcc tgaaggagca cgcgatttca ttgttccgag ccgtatgaat cctggacaat
     7621 tctatgcact accacaaagc cctcaaaccc taaagcaatt gctcatggta ggtggcgtag
     7681 accgttattt tcagattgta aagtgcttcc gtgacgaaga tcttcgtgct gatcgtcaac
     7741 cagagtttac acagattgac tgcgaaatga gtttcgtaga acaggacgat atcatcaaca
     7801 cctttgaggg aatggctaaa tatttgttca aaaccgtacg cggtgtagaa ctaggaaatg
     7861 aaccattcct ccgcttgcca tggattgaag ccatgaagcg cttcggttct gacaaacctg
     7921 atatgcgctt cggtatggag tttgtcgagt taatggacat ccttaaaggc tctggcgaat
     7981 ttagcgtttt caatgaagca gaatatgttg gaggtatttg tgtccctggt tgcgctgatt
     8041 atactagaaa acaactggat gaacttacaa actttgtaaa gagtccacaa attggagcca
     8101 agggacttgt ttacgcaaaa gtcaatgaag atggaacaat caaatctagt gttgataagt
     8161 tctatagtgt agatgttttg caaaagctcc aagaagcaat gggggctaat cctaatgatt
     8221 taatccttat cctttctggc ctaaatgcaa tgaaaacacg caagcaactc tgtgagcttc
     8281 gcttgttgat gggagaacgc ttagggctcc gcgaccataa taaatttgct ctcttgtggg
     8341 tcgttgattt ccccatgttc gagtggagcg aagaggaaca gcgactcatg gcaatgcatc
     8401 accccttcac aagtccgaaa ccttctgata tagccctact ggatactgca cctgaaaaag
     8461 cttgtgctga tgcctacgat atggtttgca atggtataga agttggtggg gggagcattc
     8521 gtatctacga tgccaaactc caagctaaaa tattcgaagt ccttggtttt actcctgaaa
     8581 aggcacaaga acaatttggg ttcttaatca atgcatttaa atatggtgca cctcctcatg
     8641 gtggtctcgc ctatggtttg gatcgctggg taagtatctt tgctggactc gatagtattc
     8701 gcgactgcat cgccttccca aagaataaca gcggtagaga tgttatgctc gatgccccaa
     8761 cagcggttga tcctaaacaa ttagatgaat tatttattaa gctagattta aaacagatat
     8821 aatttctaag gcacaggtct cttgacttgt gcctttttta tgcagaaatt agaaaaaagg
     8881 agtattacaa gaaaaaaaac tgtaatattc ctttatttat tgaatctttc tgtatttttg
     8941 aggcaaaata atcgaataca atgagcgaga aaagcaaaca cttcccagcc tgccacgtag
     9001 tattccctcc taattgtgag gaaaggcgag ctgcattcta tcttgcagca gaagaatacg
     9061 tagcagaaac ttttaatgaa gataactata tatttacatg gcagctatcc cctacttgtg
     9121 tctttggaag aaatcaaatt ccacattcag aattagatgt ggatttctgc aacaaaaatg
     9181 ggatagactt gtgtcgtcga aaaagtggag gaggaacaat ctttgccgac cgcaataaca
     9241 taatgattag cttaatcacg cctgcatgcg atgttgaatc tctttttgca gaatatgcag
     9301 aaactgtatc tgcaggatta agaaagctag gcgctccaac aaaggtctcg ggtcgtaatg
     9361 atattattct tgaagatggc agaaaagttt gcggtaatgc attctatcat caagcaaata
     9421 gaaatattgt acatggaact atgctctatg gaacagatgt cgagaaaatg atcggtgcgc
     9481 taacccctga taaagctaag ctagagtcaa agggcgtcat tagcgttaaa agccgtattg
     9541 gtgaactcaa ggaatactta cctttcgatg ttactactct gcgctctcgg ctaatagcca
     9601 tgcttaccaa taagagtttg gaactttcag aaaaagatat aaaatcaatt gaagatttag
     9661 aacagaccta ctatgctcca acctatctat ggggacacaa ggcaaagtct gacatttgca
     9721 gaacagagcg tattgagcag tgcggaacag tccaagtaaa tataaccctt cgtggttcac
     9781 ttatagattc tataacactt tctggagact tctttgaaat tggaaagaac gtaaaagatg
     9841 ctttctataa tctattccat gaaataccat acaatcgagc tgagttaaag catatcctag
     9901 acctacatca tcccgaaaaa ctaattcgta acctgagcga ggatgagctt ctcaatctat
     9961 tgtgtccgtg aaataacatc taaaacctaa ataatcaatt atggataaaa taacttgttt
    10021 acatgacaaa cacgtagcat taggggccaa tatggttccg tttggaggtt ttgatatgcc
    10081 tctatactac gataatattg ttgctgaaca tgaagccgta cggcagaaag tcggagtttt
    10141 cgatgtaagc catatgggcg aagttaaagt tactgggatt gaagcggaaa aatttgttca
    10201 gtacattttt accaacgata ttaaagatgc agagattggt aaaattttct atggcatgat
    10261 gcttcatgaa aatggaggaa ctattgacga cctcttggta tataaaatgg gtgaacaaga
    10321 ctttctcctt gtcataaatg ctgcaaacat agaaaaagac tatgcacata tcgttcaata
    10381 tgccaaggat ttcaatgtaa agacagaaaa cctaagcgac atttatggac aagttgccat
    10441 tcaaggtcca gaaagtgaaa taaccgtaga aaatgtttta ggaataaagt gcagtgatct
    10501 tactttttat acctttaaga ctatccactt tgaggacgaa gaaataatca tctcacgtac
    10561 gggctataca ggtgaagatg gatttgaaat ctatgcatct cataccatca tacaatttat
    10621 ttgggataaa cttattgagg caggcattca accttgtggc ttaggatgtc gagacactct
    10681 gcgttttgaa gttggcctcc cactctatgg cgatgagctc tcagatgaaa ttagccctat
    10741 catgagcgga ctcagtatgt tcgtaaagct tgaaaaggat aattttcttg ggaaagaggc
    10801 ttgcgtagat caaaaagaga acaagacata taagcagcga gttattggta ttgagcttca
    10861 agagaaaggt attcctcgca atgggtatcc tgtacaagct gaaggaaaag atatcggata
    10921 tgtaacaacg ggatataaat ccatatcgac aggaaaattt atttgtatgg ctctcattga
    10981 taaaaactat gcgaaacttg aaactcctgt agatgtttta atccacaata agccacgcaa
    11041 gggtattgtg gtgaagaaac gcttctatca gaagaattat aaaaaataaa agacaagacg
    11101 gcaaacctaa tcaaatataa atattatggc aaaaatcatt gaaggactct attatagtga
    11161 gtcgcatgaa ttcgtgaaag tagaaggcga atatgcatat atcggcatta ccgactttgc
    11221 acaagaacaa ctgggaaacg taacttatat tgaattccca gaaattgatg aagaaataag
    11281 cgcaggtgac agttttggtt ctgtagagag cgttaaagca gcaagcgact taacgtcacc
    11341 tgttagtggc gttgttgtcg aagtaaatga agtccttgaa gatgagcccg agttagtcaa
    11401 taaagacgct tattcaaatt ggcttattaa ggtcaaactt tcagatcctt ctgaacttga
    11461 aagcctgatg gacgctcaag cgtataccga tatctgcaaa taataaagaa catttaggat
    11521 ttggcaatta gattcacccc tttgaatcta aagccaaatc ttttaatttt ccctatacca
    11581 tgtacaaata ctttccacac acagaagaag aaattcagga aatgctgaag acgattggtg
    11641 tgaactcact tgaggaactc tatgcagaaa ttcctgaaga actgaaagtc aaacaagaac
    11701 tgaatattac ttcagcaaaa tccgaaatgg aagttcgcaa aaaacttcaa gatttagccg
    11761 aagcaaatat cactccgata tgctttgccg gtgctggggc ttatgatcac taccaaccaa
    11821 gcatcattcc ctacattgca tctcgctctg aattctcaac ttcttatacc ccgtatcaag
    11881 ctgaaatatc ccaaggcacg cttgcttaca tctttgagta ccaaacaatg atggctcgcc
    11941 tgacaggtat ggaagtaagt aatgcttcca tgtatgatgg tgcaactgcc acagctgagg
    12001 ccatgatgat gtgtattcat gctgcacgca aaaaaaacac ggtgcttatt tctgatactt
    12061 ttgctcctaa cacgcttaga gttgttgaaa catatgccaa cttccacaac gtaaacctag
    12121 aacgtattcc tgccattcac ggtgtaacag ataaggagtt tttagctaaa cgcctccagg
    12181 aggaggaagt agcaggcatt atcgttgctc aacccaacta ctatggcgtt attgaagatt
    12241 tcgatggata tgctgaacta tgtcattctc ataaagcact ttttgttatc aactctatgg
    12301 cttctgcact tggtgtactg aaaactccag gagaatgggg tgcagacatt gcttgtggcg
    12361 atgcacaaag tcttggattc ccgcttaatt ttggaggacc ttatatcggt tatctttgca
    12421 cgaagaaaga acacgttcgt aagatgcctg gacgccttgt cggtgcaaca actgacgcta
    12481 atggtcagcg ttgctttgtc cttacattac aagctcgaga gcagcatatc cgacgagaga
    12541 aagcaacatc taatatctgc acagcccaag gtgtcatgtg tttgtatgtt gcaatctatt
    12601 taagccttat gggagagaaa gggctcagag aagtaaacga acaaagctat gctggtgcac
    12661 actatttaca tgataaactc ctcaaaactg gtaagttcaa acaagtttac gacaaaccct
    12721 ttttaaacga attctgtttg cgttacaaag gcaatgtaga taaattcatt cgtgaaagta
    12781 tagaaaagca tcatatcttc ccaggagtca aaatagagaa ctctgaaaac gacattctta
    12841 tagccgtcac tgaaaaacgc agcaaagaag aaatcgatca atacattcaa ctcatcaagt
    12901 aaaataggga aacactatga ataatgtata ttatgggaat ttaatttttg agatttccaa
    12961 agcaggacgc gttggatatt ctttacccaa aagtaaaata gaaggttaca agacagcaga
    13021 actaccatct acccttctaa gatccaacaa agtagaactc cctgaggccg acgaactaac
    13081 agttgttcgc cattacacaa atgccagcaa taataatttt ggtgttgata ctggctttta
    13141 tcctctcggt agttgtacga tgaagtataa tcccaaaatc aacgaagaag ttgcagccct
    13201 accaggattt acccagatac atcctcttca acccgtagaa acagcgcagg gagttttaaa
    13261 gctctatgat gaggaacaaa aaactctttc tgaaatcacg ggcatgagcc gctttactct
    13321 gaatcctttt gcgggagctc acggagagtt aacgggactc atgaccatcc gtacttatca
    13381 cacaagacgt ggagatacta agcgtacaaa aattattgtt cccgactctg ctcacggcac
    13441 aaatccggct agcgcagcag tctgcggaat gcaaatagtt gaagtcaaga gcacaccaga
    13501 gggcactgtc gatgtagaag atttgaaacc tcttttaggg gacgatattg caggaatgat
    13561 gatgacaaac cccaacacat tgggtatctt cgaaacctca ataccagaaa ttgcacgttt
    13621 agtgcatgaa tgtggcggac ttatgtacta tgatggagca aacttcaacc ctatgctggg
    13681 cgtttgccga ccaggagaca tgggctttga tgttgttcat ctcaatttgc ataaaacttt
    13741 ttcaacacct catggtggtg gcggtccagg tgcaggtcct gttggtgttc gcaaggactt
    13801 agaagactat ttgcccaatc cacaagtcta ccagaaagat gatggcagct actctgtacg
    13861 tgttgatgca gaggcattag gcagtatcag ttctttcttt ggaaacttcg gaattcttgt
    13921 ccgcagctat gcttaccttc tcagcttagg aaaagaaaat atagcaatgg ccggaaaatt
    13981 ggcagtgctg aatgcgaact acatcaaaga atgcctaaag agccattacg aactgccaat
    14041 aaaaggattg tgcaaacacg aattcgtctt caatggaatg aaagaagaat atagtggaaa
    14101 gcatgaagat cccactcatg ttacaacact cgacatagct aaacgtttgc tcgactatgg
    14161 tttccacgcc ccaacaatat acttccccct actattccat gaggccatca tgatagaacc
    14221 tacggaaaca gaaagcaaga atacgctaga caatttcatc caagctatga agcaaatagc
    14281 agaagaggca aaggctgata aacaactcct taagacagct cctcaccgca ctcctatcaa
    14341 acggcttgat gatgtcaaag ctgtgaaagc tgccattttc agatttgaag atcttgataa
    14401 agagtagtgc catggaaaca aaagatttaa ttatcattgg aacaggtcct ggaggatacg
    14461 atgttgctgt aaaggctgct aaagctggtt tgcaggtagc aattttcgaa aagctgcact
    14521 atggtggcac gtgtctcaat gtagggtgta ttccgactaa aaccctctgc aaaaatgccg
    14581 aacttttaga agaaataaaa gcagcagagg atttcggcat agatatcaaa gagagctctc
    14641 tcgatatgtc ccgcgtcatt gctcggaaaa atggaatcgt agaaaagctc tctggagcta
    14701 ttgaggcact tatgaaaaca cctggtatca ccttcgtaaa aggagatgcc aaatttattg
    14761 atgctcacac tataggtgca gaaaatcaag tcttcacggc tcccaatatt atcattgcca
    14821 ctggctcaac cactaagttt ctcccaatag aaggagctca tagtaaaggg gttgttactt
    14881 ccacagagat gctcaaccta gaatatgtgc caaaacgctt atgcgttatc gggggaggtg
    14941 tcataggctt ggaatttgcc tctattttca atgcctttgg aagccaagtt acggtcattg
    15001 aattctgcaa agaaattctc cctccattcg accgcgacat tgcaaagcgg ctacgaacga
    15061 ttctgaagaa aaaaggaatc gatttcaaga ttggttcagc cgtcgtaggt attcaagaag
    15121 ctgacgatgc atatttggta gaatttgaag agaaggggga aaagaaatgt gttacttctg
    15181 atctagtttt gatggctgtt ggccgtgaag ccaacctctc ctccctgaat cttgatgacg
    15241 ttggcattca ttacacaaaa aaaggcatcg aagttgacga atttatgcaa accaacgtgc
    15301 caggcattta tgccgttggt gatatcaatg gtagaatgca attggctcat gctgccactt
    15361 tccaaagcta tgtagcatta gatcatatct taggagttaa aagtcaaata catcttcaag
    15421 tatgccctgc tgttgtgttc acgagtccag aagtagccat gattggaaaa accgaggaag
    15481 aactcaagtc ggcaaagatc aattacgaag tacataaaag tatgtatcgt gcaaacggta
    15541 aagcactaac aatgggctgt gatgaaggat tggttaaagt gcttacggat atgggcggac
    15601 acattcttgg agctcacatc cttggagctc acgctgctga ccttatccat gagtttgcgc
    15661 ttgtgatgaa cgaatcatta aagattgaca ctctaagaaa caccattcat gctcacccat
    15721 cgctcagtga gattatcatg aagatttgat aaattttaga ataccacaaa cgaaagaact
    15781 ccgcaaccag ttggctgcgg agtctttttt aaaaatcgct tgtctcacga caaacaatct
    15841 tcactaacct taaatctaat accatgaaaa acattgcaaa tgtacgggtt cggggcgaag
    15901 tttgcaaaca tatccaataa aaaaaaacat tttatctaag tatgttttgt tttttgtgcg
    15961 ctaattcaag gataatcagt tcaaaaaagc aactccaaat agcaactttc acacaaagaa
    16021 aatatgataa ggtaatgtcc gaaaaagtgt gtaagattct cctcgtcctt accctgatgc
    16081 ttggggtacc ccaagcatca gggtaatttg tggtgttgat atttctttac cattttatct
    16141 gattttccac tcccgaaaat acggcagccg tcttgcatat gtcccttctg ttttctcctt
    16201 ggcaacagat cccaagagat aaactacaga ggtgggagaa ggcatcgccc cacgcatgag
    16261 caaggtgcgc ttgtaacttc tattcaatcg ttccacccag ttggtagagt aaatcattcg
    16321 gcgcacactg tcggagaacc tcaaataggt gaaataggcc gcgttgcgct cattgcccaa
    16381 acgggcaagg ctcgggtact ttttgcccca acgctgcgca aaggttcgca atttctcata
    16441 accccaattc ggtttaagaa acgctttttc atgagtttgt taaaccgcac acgcatcctt
    16501 tcggccttga cctaaaaccg aagtataatt gtt
//
