LOCUS       NC_004337.2            24177 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_004337.2 Shigella flexneri 2a str. 301 chromosome, complete
            genome.
ACCESSION   NC_004337
VERSION     NC_004337.2
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-13 23:39:45
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 3010023
            Orig. end    :: 3034200
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..24177
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[3020023:3024200]"
                     /cutoff="10000"
                     /detection_rule="(minimum(3, [AdoMet_dc, Amidinotransf,
                     Arginase, OKR_DC_1, OKR_DC_1_7_arginine, OTCace]) or
                     ((OKR_DC_1_5_ornithine or OKR_DC_1 or Orn_Arg_deC_N) and
                     minimum(1, [Arginase, OTCace, OTCace_N, PAD_porph])))"
                     /neighbourhood="10000"
                     /product="Arginine2putrescine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14177
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(3, [AdoMet_dc, Amidinotransf,
                     Arginase, OKR_DC_1, OKR_DC_1_7_arginine, OTCace]) or
                     ((OKR_DC_1_5_ornithine or OKR_DC_1 or Orn_Arg_deC_N) and
                     minimum(1, [Arginase, OTCace, OTCace_N, PAD_porph])))"
                     /neighbourhood="10000"
                     /product="Arginine2putrescine"
                     /protocluster_number="1"
     cand_cluster    1..24177
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(minimum(3, [AdoMet_dc, Amidinotransf,
                     Arginase, OKR_DC_1, OKR_DC_1_7_arginine, OTCace]) or
                     ((OKR_DC_1_5_ornithine or OKR_DC_1 or Orn_Arg_deC_N) and
                     minimum(1, [Arginase, OTCace, OTCace_N, PAD_porph])))"
                     /kind="single"
                     /product="Arginine2putrescine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..24177
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="Arginine2putrescine"
                     /region_number="16"
                     /rules="(minimum(3, [AdoMet_dc, Amidinotransf, Arginase,
                     OKR_DC_1, OKR_DC_1_7_arginine, OTCace]) or
                     ((OKR_DC_1_5_ornithine or OKR_DC_1 or Orn_Arg_deC_N) and
                     minimum(1, [Arginase, OTCace, OTCace_N, PAD_porph])))"
                     /tool="gutsmash"
     CDS             531..1208
                     /locus_tag="ctg1_3156"
                     /transl_table=11
                     /translation="MLTLNKISYRWPGAATDCLCDISLQLKQGEWLALTGDNGAGKSTL
                     LRVMAGLLTPTAGTVMLQQQAMKNLKNRQRAAKVGVLFQEAENQLFHSTVADEIAFGLK
                     LQKCPADEITQRTHAALQCCQLADTANSHPLDLHNAQRRMVAVACLEALSPPLLLLDEP
                     SRDFDENWLSVFESWLEKCRQRGTSVVAISHDAAFTRRHFSRVVRLEDGVIRNVNPPDD
                     IHP"
     CDS             complement(1180..1893)
                     /locus_tag="ctg1_3157"
                     /transl_table=11
                     /translation="VKIELTVNGLNVQAQYHDEEIERVHKLLLRMLAALQTVNPQRRTV
                     VFLCAPPGTGKSTLTTFWEYLAQQDPELPAIQALPMDGFHHYNSWLDAHQLRPFKGAPE
                     TFDVAKLAENLRQVVEGDCTWPQYDRQKHDPVEDALHVTAPLVIVEGNWLLLDDEKWCQ
                     LAQFCDFSIFINAPAAALRERLVGRKLAGGVSLADAEAFYDRTDGPNVRRGLEESLPAN
                     LTLMMTATGEYRLVD"
     CDS             complement(1890..2399)
                     /locus_tag="ctg1_3158"
                     /transl_table=11
                     /translation="MATLTEDDVLEQLDAQDNLFSFMKTAHSILLQGIRQFLPSLFVDN
                     DEEIVEYAVKPLLAQSGPLDDIDVALRLIYALGKMDKWLYADITHFSQYWHYLNEQDET
                     PGFADDITWDFISNVNSITRNATLYDALKAMKFADFAVWSEARFSGMVKTALTLAVTTT
                     LKELTP"
     CDS             complement(2421..3197)
                     /locus_tag="ctg1_3159"
                     /transl_table=11
                     /translation="MLWIGEEVGKGDGPEVDIAVDPIEGTRMVAMGQSNALAVMAFAPR
                     DSLLHAPDMYMKKLVVNRLAAGAIDLSLPLADNLRNVARALGKPLDKLRMVTLDKPRLS
                     AAIEEATQLGVKVFALPDGDVAASVLTCWQDNPYDVMYTIGGAPEGVISACAVKALGGD
                     MQAELIDFCQAKGDYTENRQIAEQERKRCKAMGVDVNRVYSLDELVRGNDILFSATGVT
                     GGELVNGIQQTANGVRTQTLLIGGADQTCNIIDSLH"
     CDS             complement(3213..3386)
                     /locus_tag="ctg1_3160"
                     /transl_table=11
                     /translation="MMSLAWPLFRVTEQAALAAWPQTGCGDKNKIDGLAVTAMRQALND
                     VAFRGRVVIGEG"
     CDS             complement(3383..4624)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_3161"
                     /sec_met_domain="ADH_N (E-value: 2.3e-07, bitscore: 28.8,
                     seeds: 68, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 3.4e-25, bitscore:
                     86.7, seeds: 88, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LESLPEFELPEITDNELLVSVISDSVCLSTWKAALLGSEHKRVPD
                     DLENHPVITGHECAGVIVEVGKNLTGKYKKGQRFVLQPAMGLPSGYSAGYSYEYFGGNA
                     TYMIIPEIAINLGCVLPYHGSYFAAASLAEPMCCIIGAYHANYHTTQYVYEHRMGVKPG
                     GNIALLACAGPMGIGAIDYAINGGIQPSRVVVVDIDDKRLAQVQKLLPVDLAASKGIEL
                     VYVNTKGMSDPIQMLRALTGDVGFDDIFVYAAVPAVVEMADELLAEDGCLNFFAGLTDK
                     NFKVPFNFYNVHYNSTHVVGTSGGSTDDMKEAIALSATGQLQPSFMVTHIGGLDAVPET
                     VLNLPDIPGGKKLIYNGVTMPLTAIADFAEKGKTDPLFKELARLVEETHGIWNEQAEKY
                     LLAQFGVDIGEAAQ"
     CDS             complement(4626..5129)
                     /locus_tag="ctg1_3162"
                     /transl_table=11
                     /translation="MSRQCTHYGRWPQHGFTSLKKLRPQSVTSRIQPGSDVIVCAEMDE
                     HWGYVGAKSRQRWLFYAYDRIRRTVVAHVFGERTLATLERLLSLLSAFEVVVWMTDGCP
                     LYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLVRKSLSFSKSVELHDKVIGHYLNI
                     KHYQ"
     CDS             5814..6722
                     /locus_tag="ctg1_3163"
                     /transl_table=11
                     /translation="MKAPVSLTSFRPQKSLAIAIGVLAVVVLPFLSYYTVNEGERGILL
                     RYGKIVKVAEPGLGFKIPFMESVEKISTRNQAVVYQGLQAYSRDQQPAQMTVSVSFHIK
                     PSEAGAVYTTYNTIEALKDRLIVRQLPTQLENIFGQYTAISAVQDRTKLVQDLQNAMRK
                     AVVGPVVIDGVQIENIDFSDAYEKSIENRMKAEVAIATRKQNLETEKIQAQIAVTQAQA
                     EADSKLAAAKAEAETIRVRGAAEAETIRLKSAAEAEAIRLRGEALRDNPGLVALTTAER
                     WDGKLPDTMIPGSTVPFISTK"
     CDS             complement(6768..8759)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transketolase_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transket_pyr"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transketolase_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_3164"
                     /sec_met_domain="Transketolase_C (E-value: 2e-20, bitscore:
                     71.1, seeds: 80, tool: rule-based-clusters)"
                     /sec_met_domain="Transket_pyr (E-value: 9.4e-45, bitscore:
                     150.6, seeds: 81, tool: rule-based-clusters)"
                     /sec_met_domain="Transketolase_N (E-value: 2.3e-175,
                     bitscore: 580.5, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSRKELANAIRALSMDAVQKAKSGHPGAPMGMADIAEVLWRDFL
                     KHNPQNPSWADRDRFVLSNGHGSMLIYSLLHLTGYDLPMEELKNFRQLHSKTPGHPEVG
                     YTAGVETTTGPLGQGIANAVGMAIAEKTLAAQFNRPGHDIVDHYTYAFMGDGCMMEGIS
                     HEVCSLAGTLKLGKLIAFYDDNGISIDGHVEGWFTDDTAMRFEAYGWHVIRDIDGHDAA
                     SIKRAVEEARAVTDKPSLLMCKTIIGFGSPNKAGTHDSHGAPLGDAEIALTREQLGWKY
                     APFEIPSEIYAQWDAKEAGQAKESAWNEKFAAYAKAYPQEAAEFTRRMKGEMPSDFDAK
                     AKEFIAKLQANPAKIASRKASQNAIEAFGPLLPEFLGGSADLAPSNLTLWSGSKAINED
                     AAGNYIHYGVREFGMTAIANGISLHGGFLPYTSTFLMFVEYARNAVRMAALMKQRQVMV
                     YTHDSIGLGEDGPTHQPVEQVASLRVTPNMSTWRPCDQVESAVAWKYGVERQDGPTALI
                     LSRQNLAQQERTEEQLANIARGGYVLKDCAGQPELIFIATGSEVELAVAAYEKLTAEGV
                     KARVVSMPSTDAFDKQDAAYRESVLPKAVTARVAVEAGIADYWYKYVGLNGAIVGMTTF
                     GESAPAELLFEEFGFTVDNVVAKAKALL"
     CDS             9037..9795
                     /locus_tag="ctg1_3165"
                     /transl_table=11
                     /translation="MKIRALLVAMSVATVLTGCQNMDSNGLLSSGAEAFQAYSLSDAQV
                     KTLSDQACQEMDSKATIAPANSEYAKRLTTIANALGNNINGQPVNYKVYMAKDVNAFAM
                     ANGCIRVYSGLMDMMTDNEVEAVIGHEMGHVALGHVKKGMQVALGTNAVRVAAASAGGI
                     VGSLSQSQLGDLGEKLVNSQFSQRQEAEADDYSYDLLHQRGISPAGLATSFEKLAKLEE
                     GRQSSMFDDHPASAERAQHIRDRISADGIK"
     CDS             complement(10001..10921)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2putrescine: Arginase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_3166"
                     /sec_met_domain="Arginase (E-value: 6.6e-86, bitscore:
                     286.4, seeds: 235, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTLGHQYDNSLVSNAFGFLRLPMNFQPYDSDADWVITGVPFDMA
                     TSGRAGGRHGPAAIRQVSTNLAWEHNRFPWNFDMRERLNVVDCGDLVYAFGDAREMSEK
                     LQAHAEKLLAAGKRMLSFGGDHFVTLPLLRAHAKHFGKMALVHFDAHTDTYANGCEFDH
                     GTMFYTAPKEGLIDPNHSVQIGIRTEFDKDNGFTVLDACQVNDRSVDDVIAQVKQIVGD
                     MPVYLTFDIDCLDPAFAPGTGTPVIGGLTSDRAIKLVRGLKDLNIVGMDVVEVAPAYDQ
                     SEITALAAATLALEMLYIQAAKKGE"
     CDS             complement(11057..11431)
                     /locus_tag="ctg1_3167"
                     /transl_table=11
                     /translation="MNYQLYVRNYSRNTNYEIVATADGLDVLNGKQGSLNNNGYIVNAG
                     DSLVIKGFRKDKHTEAAFQFANVADSYAANSAQGDVRNTGVIGFAAFELQGPAQNALPP
                     CSGQAFPADNNGYAPPPCRK"
     CDS             complement(11457..11960)
                     /locus_tag="ctg1_3168"
                     /transl_table=11
                     /translation="MSRQCTHYGRWPQHGFTSLKKLRPQSVTSRIQPGSDVIVCAEMDE
                     HWGYVGAKSRQRWLFYAYDRIRRTVVAHVFGERTLATLERLLSLLSAFEVVVWMTDGWP
                     LYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLVRKPLSFSKSVELHDKVIGHYLNI
                     KHYQ"
     CDS             complement(11971..12183)
                     /locus_tag="ctg1_3169"
                     /transl_table=11
                     /translation="VYDGDFKVLAWLPFPSDVLPAPLLKAWCVTAKALPDISAISALIA
                     VKHGNYSSLTPPLSPVSTRKSLIWP"
     CDS             complement(12183..14177)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2putrescine: Orn_Arg_deC_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_3170"
                     /sec_met_domain="Orn_Arg_deC_N (E-value: 3.5e-73, bitscore:
                     244.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDDMSMGLPSSAGEHGVLRSMQEVAMSSQEASKMLRTYNIAWWG
                     NNYYDVNELGHISVCPDPDVPEARVDLAQLVKTREAQGQRLPALFCFPQILQHRLRSIN
                     AAFKRARESYGYNGDYFLVYPIKVNQHRRVIESLIHSGEPLGLEAGSKAELMAVLAHAG
                     MTRSVIVCNGYKDREYIRLALIGEKMGHKVYLVIEKMSEIAIVLDEAERLNVVPRLGVR
                     ARLASQGSGKWQSSGGEKSKFGLAATQVLQLVETLREAGRLDSLQLLHFHLGSQMANIR
                     DIATGVRESARFYVELHKLGVNIQCFDVGGGLGVDYEGTRSQSDCSVNYGLNEYANNII
                     WAIGDACEENGLPHPTVITESGRAVTAHHTVLVSNIIGVERNEYTVPTAPVEDAPRALQ
                     SMWETWQEMHEPGTRRSLREWLHDSQMDLHDIHIGYSSGTFSLQERAWAEQLYLSMCHE
                     VQKQLDPQNRAHRPIIDELQERMADKMYVNFSLFQSMPDAWGIDQLFPVLPLEGLDQVP
                     ERRAVLLDITCDSDGAIDHYIDGDGIATTMPMPEYDPENPPMLGFFMVGAYQEILGNMH
                     NLFGDTEAVDVFVFPDGSVEVELSDEGDTVADMLQYVQLDPKTLLTQFRDQVKKTDLDA
                     ELQQQFLEEFEAGLYGYTYLEDDAANLLI"
     CDS             complement(14665..14916)
                     /locus_tag="ctg1_3171"
                     /transl_table=11
                     /translation="VVADPTTTLQVKNTGSLSVNRYGWINIWMAILGQFFTRFPLFFES
                     CLILLKTWLEIFPDNAGILRIYLLQFSAIVGYKTRRAA"
     CDS             14972..16126
                     /locus_tag="ctg1_3172"
                     /transl_table=11
                     /translation="MAKHLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETY
                     VKTGMVLVGGEITTSAWVDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPDIN
                     QGVDRADPLEQGAGDQGLMFGYATNETDVLMPAPITYAHRLVQRQAEVRKNGTLPWLRP
                     DAKSQVTFQYDDGKIVGIDAVVLSTQHSEEIDQKSLQEAVMEEIIKPILPAEWLTSATK
                     FFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARY
                     VAKNIVAAGLADRCEIQVSYAIGVAEPTSIMVETFGTEKVPSEQLTLLVREFFDLRPYG
                     LIQMLDLLHPIYKETAAYGHFGREHFPWEKTDKAQLLRDAAGLK"
     CDS             16563..17957
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sugar_tr"
                     /gene_functions="transport (smcogs) SMCOG1007:sugar and
                     other transporter (Score: 471.5; E-value: 9.4e-144)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_3173"
                     /sec_met_domain="Sugar_tr (E-value: 7.2e-142, bitscore:
                     471.5, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDAKKQGRSNKAMTFFVCFLAALAGLLFGLDIGVIAGALPFIAD
                     EFQITSHTQEWVVSSMMFGAAVGAVGIGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPN
                     VEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTA
                     FSYTGAWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFVDAERVLLRLRDTSAEAK
                     RELDEIRESLQVKQSGWALFKENSNFRRAVFLGVLLQVMQQFTGMNVIMYYAPKIFELA
                     GYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLGTMMHI
                     GIHSPSAQYFAIAMLLMFIVGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANM
                     IVGATFLTMLNTLGNANTFWVYAALNVLFILLTLWLVPETKHVSLEHIERNLMKGRKLR
                     EIGAHD"
     CDS             18076..18531
                     /locus_tag="ctg1_3174"
                     /transl_table=11
                     /translation="MRRLREKLAQANLKLGRNYPEPKLSYTQRGTSAGTAWLESYEIRL
                     NPVLLLENSEAFIEEVVPHELAHLLVWKHFGRVAPHGKEWKWMMESVLGVPARRTHQFE
                     LQSVRRNTFPYRCKCQEHQLTVRRHNRVVRGEAIYRCVHCGEQLVAK"
     CDS             18626..19333
                     /locus_tag="ctg1_3175"
                     /transl_table=11
                     /translation="MYRYLSIAAVVLSAAFSGPTLAEGINSFSQAKAAAVKVHADAPGT
                     FYCGCKINWQGKKGVVDLQSCGYQVRKNENRASRVEWEHVVPAWQFGHQRQCWQDGGRK
                     NCAKDPVYRKMESDMHNLQPSVGEVNGDRGNFMYSQWNGGEGQYGQCAMKVDFKEKAAE
                     PPARARGAIARTYFYMRDQYNLTLSRQQTQLFNAWNKMYPVTDWECERDERIAKVQGNH
                     NPYVQRACQARKS"
     CDS             19413..20144
                     /locus_tag="ctg1_3176"
                     /transl_table=11
                     /translation="MRIPRIYHPEPLTSHSHIALCEDAANHIGRVLRMGPGQALQLFDG
                     SNQVFDAEITSASKKSVEVKVLEGQIDDRESPLHIHLGQVMSRGEKMEFTIQKSIELGV
                     SLITPLFSERCGVKLDSERLNKKLQQWQKIAIAACEQCGRNRVPEIRPAMDLEAWCAEQ
                     DEGLKLNLHPRASNSINTLPLPVERVRLLIGPEGGLSADEIAMTARYQFTDILLGPRVL
                     RTETTALTAITALQVRFGDLG"
     CDS             20157..21107
                     /locus_tag="ctg1_3177"
                     /transl_table=11
                     /translation="MIKLGIVMDPIANINIKKDSSFAMLLEAQRRGYELHYMEMGDLYL
                     INGEARAHTRTLNVKQNYEEWFSFVGEQDLPLADLDVILMRKDPPFDTEFIYATYILER
                     AEEKGTLIVNKPQSLRDCNEKLFTAWFSDLTPETLVTRNKAQLKAFWEKHSDIILKPLD
                     GMGGASIFRVKEGDPNLGVIAETLTEHGTCYCMAQNYLPAIKDGDKRVLVVDGEPVPYC
                     LARIPQGGETRGNLAAGGRGEPRPLTESDWKIARQIGPTLKEKGLIFVGLDIIGDRLTE
                     INVTSPTCIREIEAEFPVSITGMLMDAIEARLQQQ"
     CDS             21144..21779
                     /locus_tag="ctg1_3178"
                     /transl_table=11
                     /translation="VTAPFFPRILGAVAFLNQETEPLTMNLQHHFLIAMPALQDPIFRR
                     SVVYICEHNTNGAMGIIVNKPLENLKIEGILEKLKITPEPRDESIRLDKPVMLGGPLAE
                     DRGFILHTPPSNFASSIRISDNTVMTTSRDVLETLGTDKQPSDVLVALGYASWEKGQLE
                     QEILDNAWLTAPADLNILFKTPIADRWREAAKLIGVDILTMPGVAGHA"
     CDS             21779..22195
                     /locus_tag="ctg1_3179"
                     /transl_table=11
                     /translation="MSGTLLAFDFGTKSIGVAVGQRITGTARPLPAIKAQDGTPDWNLI
                     ERLLKEWQPDEIIVGLPLNMDGTEQPLTARARKFANRIHGRFGVEVKLHDERLSTVEAR
                     SGLFEQGGYRALNKGKVDSASAVIILESYFEQGY"
     CDS             complement(22371..23351)
                     /locus_tag="ctg1_3180"
                     /transl_table=11
                     /translation="MNMEEIVALSVKHNVSDLHLCSAWPARWRIRGRMEAAPFDAPDVE
                     ELLREWLDDDQRAILLENGQLDFAVSLAENQRLRGSAFAQRQGISLALRLLPSHCPQLE
                     QLGAPPVLPELLKSENGLILVTGATGSGKSTTLAAMVGYLNQHADAHILTLEDPVEYLY
                     ASQRCLIQQREIGLHCMTFASGLRAALREDPDVILLGELRDSETIRLALTAAETGHLVL
                     ATLHTRGAAQAVERLVDSFPAQEKDPVRNQLAGSLRAVLSQKLEVDKQEGRVALFELLI
                     NTPAVGNLIREGKTHQLPHVIQTGQKVGMLTFQQSYQQRVGEGRL"
     CDS             23369..24073
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Ala_racemase_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_3181"
                     /sec_met_domain="Ala_racemase_N (E-value: 1.6e-30,
                     bitscore: 104.5, seeds: 314, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDIAHNLAQVRDKISAAATRCGRSPEEITLLAVSKTKPASAIAE
                     AIDAGQRQFGENYVQEGVDKIRHFQELGVTGLEWHFIGPLQSNKSRLVAEHFDWCHTID
                     RLRIATRLNEQRPAELPPLNVLIQINISDENSKSGIQLAELDELAAAVAELPRLRLRGL
                     MAIPALESEYVRQFEVARQMAVAFAGLKTRYPHIDTLSLGMSDDMEAAIAAGSTMVRIG
                     TAIFGARDYSKK"
ORIGIN
        1 atggcgggct ggtatccgga ctttctgcca agagagataa caggcacggg gacgctcctc
       61 ggtacgccca ttgggcatct cccgcttaat gaacaatccg ccaccatcca gctcgtccag
      121 caatcgccct atttgcagct ctccggctgt acctttagcg tggaagaaga agttgccttt
      181 gggccagaaa atctgtgtct tgctgaagca gagattatgg cgcggattga tgccgccctg
      241 actctgaccg agtgccagcc gttgcgccat cgtcacccgg caacactctc cggtggagag
      301 acacagcgcg tgatcatcgc ctgcgccatc gcgatgcagc caaagctctt aattcttgat
      361 gaagccttta gccgcctgac accgcaggcc agcgaaatgc tgttgcagcg cttacaacac
      421 tgggcgtttg aacgtggttc gctgattatt ctttttgaac gtcatcgcac acctttcctg
      481 aactactgcc agcaagcgtg gcaattgcaa aacggagcgc tccagccact atgttaacgt
      541 taaataagat atcttatcgc tggcctggcg cggcaacgga ttgtctttgc gacatttctc
      601 tgcaactcaa acaaggtgaa tggttggcgc tgaccggtga caatggcgca gggaaatcga
      661 cgctgttacg agtaatggca ggtcttctta cgcccacagc cggtacggtt atgctgcaac
      721 aacaggcgat gaaaaacctg aaaaaccgcc agcgcgcggc aaaggttggc gtactgtttc
      781 aggaagcgga aaaccaactt tttcacagca ccgtcgctga cgagatcgca tttggtttga
      841 aactgcaaaa atgcccggcg gatgaaatca ctcaacgtac ccatgctgcc ctgcaatgtt
      901 gtcagttagc agacactgcc aactcgcacc cgttggatct gcataatgcg cagcgacgga
      961 tggtcgccgt cgcctgcctg gaagcactct ctccgccact attactgctg gacgagccga
     1021 gtcgggattt tgacgaaaat tggttgagcg tgtttgaaag ctggctggag aagtgccgcc
     1081 agcgaggcac gagcgtggta gcaatcagtc atgacgccgc atttacccgg cgtcatttct
     1141 ctcgtgtggt gcggctggaa gatggtgtaa tcaggaacgt taatccacca gacgatattc
     1201 acccgtagcg gtcatcatta aggtcaaatt tgcaggcaga ctctcttcca gcccccggcg
     1261 aacattcggc ccgtcggtac ggtcataaaa ggcttctgca tctgccagcg atacccctcc
     1321 cgccagcttg cgccccacca gacgctcccg caacgcagca gctggcgcgt tgataaagat
     1381 cgagaaatca caaaattgcg caagctggca ccacttctcg tcgtccagca acaaccagtt
     1441 tccttcgacg atgacgagtg gtgcggtaac gtgcaacgca tcttcaacag gatcatgctt
     1501 ttgtcgatcg tactgcggcc acgtacaatc cccttccacc acctggcgca gattttccgc
     1561 cagtttcgca acgtcaaatg tctctggtgc gcctttgaag gggcgcaatt gatgcgcgtc
     1621 cagccagcta ttgtaatggt gaaaaccatc catcgggagc gcctgaatag cgggcagctc
     1681 cgggtcttgt tgcgcgagat attcccagaa ggtggttagg gtagatttac ccgtccccgg
     1741 cggagcgcaa agaaaaacca ccgtacgccg ctgcggattt accgtctgta aggccgccag
     1801 catacgcagc aacagtttat gcacgcgttc tatctcttca tcatggtact gcgcttgcac
     1861 gttcagccca ttcaccgtta attcaatttt cacggcgtta attcctttaa ggtggtcgtt
     1921 actgccagcg tcagcgccgt tttgaccatt ccgctaaaac gcgcctctga ccagacggcg
     1981 aaatcggcga acttcatcgc ttttaacgca tcgtagagcg tcgcattgcg agttatactg
     2041 ttgacattgc tgataaaatc ccaggttata tcatcggcaa atccgggcgt ttcatcctgt
     2101 tcgttcaggt aatgccagta ctgggaaaag tgcgtgatat cggcatacag ccatttatcc
     2161 attttcccca gcgcataaat caaacgcagc gcaacatcaa tatcgtcaag cgggccgctt
     2221 tgggcgagta acggcttcac tgcatattcg acgatctctt catcgttatc gacaaacagc
     2281 gacggcagaa actggcgtat cccctggagc aaaatagaat gcgcagtttt cataaatgaa
     2341 aataaattgt cctgtgcatc cagttgctca agcacatcat cttctgtcag cgtcgccatt
     2401 ggtcttccga tagatcacca tcaatgcagg gagtctatta tattacacgt ttggtccgcg
     2461 ccgccgatca gtaatgtctg cgtccgcacc ccattcgccg tctgttggat accgttcacc
     2521 aactcgccgc ccgtcacgcc cgtagcgcta aagaggatat cgttccccct caccagttca
     2581 tcgagcgagt acacacggtt aacgtcaacg cccattgcct tacaacgctt gcgctcctgc
     2641 tctgcaatct gccgattttc cgtgtaatcc cctttagcct gacaaaagtc aatcagctcg
     2701 gcctgcatat ccccgcctaa cgctttaacg gcacaggcag aaatcacgcc ttctggcgca
     2761 ccgccgatgg tgtacatcac atcgtaagga ttatcctgcc agcaggtcag cacgctggcg
     2821 gcgacatcgc catccggcag ggcaaaaacc ttcacgccca gctgtgttgc ttcttcaatc
     2881 gcggcactca gacgcggttt atccagcgta accatgcgca gcttgtccag cggtttacct
     2941 aacgcccgcg ccacgttacg caagttgtcc gccagaggca aagacagatc aatcgccccg
     3001 gcagccagtc gattaacaac cagctttttc atatacatat cgggcgcatg taacaggcta
     3061 tctcgaggag cgaaagccat gaccgccagc gcattgctct gccccatcgc caccatccgc
     3121 gtgccttcaa tgggatcaac cgcgatatcg acttctggcc catcgccttt gcccacctct
     3181 tcgccaatcc acagcatcgg cgcatggtca atttatcctt cgccgataac cactcgtcca
     3241 cgaaaagcga cgtcgtttaa tgcctggcgc atcgcggtga ccgccaggcc atcaatttta
     3301 tttttgtcgc cacatccggt ttgcggccag gcagccaacg ctgcctgttc cgtaacgcga
     3361 aataatggcc acgccaggga catcattgcg cggcctcccc gatatcaacg ccaaattgtg
     3421 ccagcagata tttctcggcc tgttcattcc agatgccgtg cgtttcctca accagccgcg
     3481 ccaactcttt aaacagcgga tcggttttgc ctttttcggc aaaatcggca atggcagtga
     3541 gcggcatggt cacgccgtta taaatgagtt ttttaccgcc agggatatcc ggcagattga
     3601 gcacggtttc tggcaccgca tccaggccac caatatgggt caccataaac gacggctgta
     3661 actgtcctgt ggcgctaagg gcaatcgcct ctttcatgtc gtccgttgaa ccgccggatg
     3721 taccgactac gtgcgtgctg ttataatgga cgttgtagaa attaaacggc actttgaagt
     3781 ttttatccgt cagcccggca aagaagttca gacagccatc ttccgccagt aattcgtcag
     3841 ccatctcaac gacagcaggc accgccgcat aaacaaaaat gtcatcgaac ccgacatctc
     3901 ctgtcagcgc ccgcagcatc tggataggat cgctcatccc tttggtattc acatacacca
     3961 gctcaatgcc tttactggcc gccagatcca ccggcagcag cttctgcacc tgcgccaggc
     4021 gtttgtcgtc gatatcgacc accaccaccc gtgacggttg tatgccaccg ttaatggcgt
     4081 aatcgatagc gccaatgccc atcggacccg cacacgccag cagtgcaata ttgccgccag
     4141 gtttgacgcc catgcgatgc tcataaacat attgcgtggt gtgataattg gcatgataag
     4201 caccaataat gcagcacata ggctctgcca gcgacgccgc agcaaaataa gagccgtgat
     4261 acggtaatac gcagcccaaa ttaatggcga tttcgggaat aatcatataa gtggcattgc
     4321 cgccaaaata ttcgtagctg tagcccgctg aatatccgct tggtaacccc atcgccggtt
     4381 gcaatacaaa acgctggcct tttttatatt tgccagtgag atttttaccc acttcgacaa
     4441 taaccccggc acattcatgc ccggtaatga ccggatgatt ttctaaatcg tcgggtacgc
     4501 gtttatgttc actaccgagt aacgccgctt tccaggtcga taaacagacg ctgtcagaaa
     4561 ttacactcac taacagttca ttatcggtaa tttctggcag ttcaaattcg ggtaatgact
     4621 ccaacttact gatagtgttt tatgttcaga taatgcccga tgaccttgtc atgcagctcc
     4681 accgattttg agaacgacag tgacttccgt accagccttg ccagatgttg tctcagattc
     4741 agattatgtc gctcaatgcg ctgagtgtaa cgcttgctga taacgtgcag ctttcccttc
     4801 aggcgtgatt catacagcgg acagccatcc gtcatccata ccacgacctc aaaggccgac
     4861 agcaggctca gaagacgctc cagtgtggcc agagtgcgtt caccgaagac gtgcgccaca
     4921 accgtcctcc gtatcctgtc atacgcgtaa aacagccagc gctgacgtga tttagcaccg
     4981 acgtagcccc aatgttcgtc catttcagcg cagacaatca catcactgcc cggttgtatg
     5041 cgcgaggtta ccgactgcgg cctgagtttt ttaagtgacg taaaaccgtg ttgaggccaa
     5101 cgcccataat gcgtgcactg gcgcgacatc cgacgccatt catggccata tcaatgattt
     5161 tctggtgctt accgggctga gaggcggtgt aagtgaactg tagttgccat gttttacggc
     5221 aatgagagca gagatagcgc tgatgtccgg cagtgctttt gccgttacgc accacgcctt
     5281 cagtagcgga gcaggaagga catctgatgg aaatggaagc cacgcaagca ccttaaaatc
     5341 accatcatac actaaatcag taagttggca gcattaccct tttgctgaat gtataactga
     5401 gattgatgat tctggaaaat aatcactaag ccgcataaat tatccttatt ttatttttag
     5461 ggtaccgtcc ggcggtaaaa ataaaatact cgtgcggttt aatgaaagca attgggtacg
     5521 cgagaagaaa aaccccacaa accaaaataa taaaacctta aataacaaca atatgaaatt
     5581 gatattttta aagtcaactt tgtatttgtt atgttcatca caaaatcaac attttgtttg
     5641 ttattgtatt tgtgatgcat atctctattt atttattgaa tgttcgaaaa catacttttc
     5701 taatgcaatg ttttttcgct ataccccttt atagattctg aattctcacc tgtcggctgt
     5761 tttctcctca tctcatgtga catattccca tactttactc aaggaagatt gtcatgaaag
     5821 cacctgtttc attaacctca tttcgcccac aaaaatctct tgctatcgcc attggcgtgc
     5881 ttgccgtggt tgtgctgcca tttctctcgt attacaccgt taatgaaggt gaacgcggca
     5941 ttttgctgcg ctacggaaaa atcgtaaaag ttgccgaacc ggggctgggt tttaagatcc
     6001 cttttatgga aagcgtggag aaaatttcca cgcgtaatca ggctgtggtc tatcagggat
     6061 tacaggccta cagccgcgac cagcaaccgg cacaaatgac agtatcagtc agcttccaca
     6121 ttaaaccttc agaagcaggc gcggtttata ccacctacaa cactattgaa gcattaaaag
     6181 atcgtctaat tgtccgtcag ttgccaactc agctggagaa cattttcggc caatataccg
     6241 ccatcagcgc cgtacaggat cgtacaaaat tggttcagga tctgcaaaat gccatgcgca
     6301 aagccgttgt tgggccagtg gtaattgacg gggtccagat tgaaaatatt gatttttctg
     6361 acgcttatga aaagtcgatt gaaaaccgaa tgaaagcaga agtcgccatt gccacgcgta
     6421 agcaaaatct ggaaacagag aaaatccagg cgcaaatagc ggtaactcag gcccaggcag
     6481 aagcagacag taaactggcg gcagccaaag cagaagcgga aactattcgc gtaagaggcg
     6541 cggcagaggc tgaaactatt cgtttaaaaa gtgcggctga agcagaagca atccgcctgc
     6601 gcggtgaagc tctgcgggat aatcccggac ttgtagccct caccactgcc gaacgttggg
     6661 acggtaaact gcccgatacc atgatccccg gcagcacagt tccgtttatc tctactaagt
     6721 aaaaaaaggg ccgctttcgc ggtccttctc acaaaacgtc ttactgatta cagcagcgct
     6781 tttgctttcg caacaacgtt atcaacagtg aagccgaact cttcaaacag cagctctgcc
     6841 ggagcagatt caccgaaggt ggtcatgccg acgatagcgc cgttcaggcc aacatacttg
     6901 taccagtagt cagcaatacc cgcttctacc gcaacgcgtg cagtaaccgc tttcggcagt
     6961 acggattcac ggtaagccgc atcctgcttg tcaaatgcgt cggtagacgg catggacacc
     7021 acgcgcgctt tcacgccttc ggcagtcagt ttttcgtagg cagcaaccgc cagttcaact
     7081 tcagaaccgg tggcgatgaa gatcagttcc ggctgaccag cacagtcttt cagcacataa
     7141 ccaccgcgcg cgatgtttgc cagctgctct tcagtacgtt cctgctgcgc caggttctga
     7201 cgggagagga taagcgcagt cgggccgtcc tgacgctcaa cgccgtattt ccacgcgacc
     7261 gcggattcaa cctggtcaca cggacgccat gtagacatgt tcggggtcac gcgcagagaa
     7321 gcgacctgct ctaccggctg gtgagtcggg ccatcttcgc ccagaccgat ggagtcgtgg
     7381 gtgtaaacca tcacctggcg ctgtttcatc agcgcagcca tacgtacggc gttacgtgcg
     7441 tattccacga acatcaggaa ggtggaggtg tacggcagga agccaccgtg cagggagata
     7501 ccgttagcaa tcgcggtcat accgaactcg cgaacaccgt agtggatgta gttacctgca
     7561 gcatcttcgt tgattgcttt agaaccagac cacagggtca ggttagacgg tgccaggtca
     7621 gcagagccgc cgaggaattc aggcaacagc gggccgaacg cttcgatagc attctgcgac
     7681 gctttacggc tggcgatttt cgccggatta gcctgcagtt tagcgataaa ctctttcgct
     7741 ttggcgtcga agtcagacgg catttcgcct ttcatacggc gggtaaattc agccgcttcc
     7801 tgcggataag ctttcgcgta agccgcaaac ttctcattcc atgcagattc tttcgcctgg
     7861 cctgcttctt tcgcatccca ctgagcatag atttcagacg ggatttcgaa cggtgcatat
     7921 ttccagccca gctgttcgcg ggtcagggca atttcagcgt cgcccagcgg cgcaccgtgg
     7981 gagtcgtgag taccggcttt gttcggggaa ccgaaaccga tgatggtttt gcacatcagc
     8041 agggacggtt tgtcagtcac tgcgcgcgct tcttcaactg cgcgtttgat ggatgccgcg
     8101 tcatgaccgt cgatgtcgcg aataacgtgc cagccgtaag cttcgaaacg cattgctgtg
     8161 tcgtcggtga accagccttc aacgtgacca tcgatagaaa taccgttgtc atcgtagaac
     8221 gcaatcagtt tacccagctt cagcgtaccc gccagagagc aaacttcgtg ggagatgcct
     8281 tccatcatgc agccgtcgcc catgaaggcg taggtgtagt ggtcgacaat gtcgtggccc
     8341 ggacggttaa actgcgccgc cagcgttttt tctgcaatcg ccataccgac tgcgttggca
     8401 ataccctgac ccagcggacc ggtggtggtt tccacaccag cggtataacc tacttccgga
     8461 tggcccggag ttttagagtg cagctgacgg aagtttttca gttcttccat cggcagatcg
     8521 taaccggtga ggtgcagcag gctgtagatc agcatggagc cgtggccgtt ggacagcacg
     8581 aagcggtcac ggtcagccca ggacggattc tgcgggttgt gtttcaggaa atcacgccac
     8641 aggacttcgg caatgtcagc catacccata ggggcacccg ggtgaccgga tttggctttc
     8701 tgtactgcgt ccatgctcag cgcacgaata gcattggcaa gctctttacg tgaggacatt
     8761 ttgactccag atcggatgat gaagggcacg cccttaacga cttgacgaca gcgcgttttg
     8821 ggctacgccg gaaaatttgc caacaattta ccgcaagccg cgcgtcatgt acatggaaca
     8881 tccttttgcc gcttcagaaa tctctggatc atgctcgcat gttgcgcaat ctgctcgccc
     8941 gtccgctgcg cttttcctta tactgagact gagcgtcgat tcacctgcaa acggcgcatt
     9001 tttagaataa tcctgacctt gtgcggaaga gaaaacatga aaattcgcgc cttattggta
     9061 gcaatgagcg tggcaacggt actgaccggt tgccagaata tggactccaa cggactgctc
     9121 tcatcaggag cggaagcttt tcaggcttac agtttgagtg atgcgcaggt gaaaaccctg
     9181 agcgatcagg catgtcagga gatggacagc aaggcgacga ttgcgccagc caatagcgaa
     9241 tacgctaaac gtctgacaac tattgccaat gcgctaggca acaatatcaa cggtcagccg
     9301 gtgaattaca aagtgtatat ggcgaaggat gtgaacgcct ttgcaatggc taacggctgt
     9361 atccgcgtct atagcgggct gatggatatg atgacagata acgaagtcga agcggtgatc
     9421 ggtcacgaga tggggcacgt ggcgttaggc catgtgaaga aagggatgca ggtggcgctt
     9481 ggtacaaatg ccgtgcgagt agctgcggcc tctgcgggcg ggattgtcgg cagtttatct
     9541 caatcacaac ttggtgatct gggcgagaaa ttagtcaatt cgcaattctc ccagcgccag
     9601 gaagcagaag ccgatgatta ttcttacgat cttctgcacc aacgcggcat cagcccggca
     9661 ggtcttgcca ccagctttga aaaactggcg aagctggaag aaggtcgtca aagctcaatg
     9721 tttgacgacc atcctgcatc cgccgaacgt gcccagcata ttcgcgatcg catcagcgcg
     9781 gatgggatta agtaaagcct agtggtgtcg aacgtaggtc agataaggcg ttcacgccgc
     9841 atctgacatt aatggcacat ttgttacctt gtgcgcattg ccggatgcga tgctggcgca
     9901 tcttatccgg cctacgggtg ccgaacgtag gtcggataag gcgttcacgc cgcatccgac
     9961 attaatggca cgttttaccc gtgcgcatcg catctggtgc ttactcgccc tttttcgccg
    10021 cctgaatata cagcatctcc agcgccagcg tcgccgcagc cagagcggtg atttccgact
    10081 gatcgtatgc cggagccact tccactacgt ccatcccaac gatgttgaga tctttcaggc
    10141 cgcgtaccag tttaatggcg cgatcggagg tcaggccgcc aatcactggc gtaccggttc
    10201 ccggcgcgaa agcaggatcc aggcagtcga tatcaaaagt caggtaaacc ggcatatcac
    10261 ccacaatctg tttcacctgg gcgataacgt catccacgct gcgatcgttc acctggcagg
    10321 cgtccagcac ggtaaagccg ttgtctttat caaactcggt acgaatacca atctgcacgg
    10381 aatgattcgg gtcgatcaga ccttctttcg gcgcggtata gaacatagtg ccgtggtcaa
    10441 attcacaacc gttcgcatag gtatcggtgt gggcgtcaaa gtgtaccagc gccattttgc
    10501 cgaaatgctt cgcatgagca cgcagcagcg gcagcgtaac aaagtggtca ccaccgaagg
    10561 agagcatacg cttaccggca gccagcagct tctcggcgtg cgcctgcagc ttttcgctca
    10621 tctcacgggc atcgccaaag gcatatacca gatcgccgca gtccacgacg ttcagacgct
    10681 cacgcatgtc gaaattccac gggaagcggt tgtgttccca ggccagattc gtcgaaacct
    10741 gacggatcgc tgccggaccg tggcgaccac ccgcacgacc agaagtggcc atatcgaacg
    10801 gcacgccagt aatcacccag tctgcatcgc tgtcatacgg ctggaagttc atcggcaggc
    10861 gtaaaaaacc aaaggcattg gaaaccagtg agttatcgta ttgatgacct aaggtgctca
    10921 tggatggact cctattacaa agtcgatata aaaaaaccct tccgcgtcgt taggcccgac
    10981 gaggaagggt tggatttgcg aaacacaagt ttgtgctaat tatcgcctta aatgggcgag
    11041 gcatcaagcg aggttgctat ttccgacacg gtggcggcgc atagccattg ttatctgccg
    11101 gaaaggcttg tccagagcac ggcggcagcg cgttttgcgc cgggccttgt aattcaaagg
    11161 cggcaaagcc gattaccccg gtattacgca catcgccttg cgccgaattg gctgcgtagg
    11221 aatcagcaac gttggcgaac tgaaaagccg cttcagtatg tttatctttg cggaatcctt
    11281 taatcactaa cgaatctccg gcattcacaa tatagccgtt gttattcagc gaaccttgct
    11341 tgccgttcag cacatccagg ccatcagccg tagcaacgat ctcgtagttg gtgttacgac
    11401 tgtaattacg gacatataat tgataattca ttccgactct gggtaatgac tccaacttac
    11461 tgatagtgtt ttatgttcag ataatgcccg atgaccttgt catgcagctc caccgatttt
    11521 gagaacgaca gtggcttccg taccagcctt gccagatgtt gtctcagatt cagattatgt
    11581 cgctcaatgc gctgagtgta acgcttgctg ataacgtgca gctttccctt caggcgtgat
    11641 tcatacagcg gccagccatc cgtcatccat accacgacct caaaggccga cagcaggctc
    11701 agaagacgct ccagtgtggc cagagtgcgt tcaccgaaga cgtgcgccac aaccgtcctc
    11761 cgtatcctgt catacgcgta aaacagccag cgctgacgtg atttagcacc gacgtagccc
    11821 caatgttcgt ccatttcagc gcagacaatc acatcactgc ccggttgtat gcgcgaggtt
    11881 accgactgcg gcctgagttt tttaagtgac gtaaaaccgt gttgaggcca acgcccataa
    11941 tgcgtgcact ggcgcgacat ccgacgccat tcatggccat atcaatgatt ttctggtgct
    12001 taccgggctg agaggcggtg taagtgaact gtagttgcca tgttttacgg caatgagagc
    12061 agagatagcg ctgatgtccg gcagtgcttt tgccgttacg caccacgcct tcagtagcgg
    12121 agcaggaagg acatctgatg gaaatggaag ccacgcaagc accttaaaat caccatcata
    12181 cactaaatca gtaagttggc agcatcatct tcaagataag tataaccgta caaacctgcc
    12241 tcgaactctt caaggaactg ttgttgcagt tcagcatcaa gatcggtttt cttcacttga
    12301 tcgcggaact gggttaacag cgttttcgga tcgagctgta catattgcag catgtccgcc
    12361 acggtatcgc cttcgtcaga cagttctact tctacgctac cgtcagggaa cacgaacacg
    12421 tcaactgctt cggtatcacc gaacaggttg tgcatattgc caaggatctc ctgatatgca
    12481 ccgaccataa agaaaccgag catcggcgga ttctctggat cgtactccgg cattggcatt
    12541 gtcgtggcaa taccatcacc atcaatatag tggtcgatag caccgtcaga gtcacaggta
    12601 atatccagca gcacagcgcg acgttccggc acttgatcca gcccttccag cggtagaacc
    12661 gggaacaact ggtcgatccc ccatgcgtcc ggcattgact ggaacagcga gaaattgacg
    12721 tacattttgt ccgccatacg ttcctgcagt tcgtcgatta tcggacgatg cgcacggttt
    12781 tgcggatcca gttgcttctg cacttcatgg cacatgctca gatagagttg ttctgcccat
    12841 gcacgttctt gcaggctaaa ggtgccggaa gagtagccga tatgaatgtc gtgcagatcc
    12901 atctggctgt cgtgtaacca ttcacgcaaa gaacggcgag ttcccggttc gtgcatttcc
    12961 tgccaggttt cccacatgct ttgcagcgca cgcggcgcat cttctacggg cgcggtcggc
    13021 accgtatatt cgttacgttc cacgccgatg atattcgaca ccagcacggt atggtgcgca
    13081 gtcaccgcac ggcccgattc ggtgattacc gtcggatgcg gcagaccatt ttcttcacac
    13141 gcatcgccaa tcgcccagat gatgttgttg gcgtattcat tgaggccata gtttacggag
    13201 cagtcagact gcgaacgggt gccttcataa tccacgccca gaccgccgcc gacgtcgaag
    13261 cactgaatat tgacgcccag cttgtgcagt tccacataga aacgcgcgga ttcacgaacg
    13321 cctgtcgcga tatcgcgaat attcgccatc tgcgaaccga ggtggaagtg cagtagttgc
    13381 aggctgtcga gacgcccggc ttcacgcagg gtttcaacca gttgcagtac ctgagtcgca
    13441 gccaggccga acttcgattt ttccccgccg gaggactgcc atttacccga gccctgcgaa
    13501 gccagacgtg cacgcacgcc cagacgagga acgacattca gacgttctgc ttcatccagc
    13561 acaatggcga tttctgacat cttctcaatg accagataga ccttgtgccc catcttctcg
    13621 ccaattaatg ccaggcggat atattcgcgg tctttataac cgttgcagac gatgacgcta
    13681 cgagtcatgc cagcatgtgc cagcactgcc atcaactcgg ctttggaacc ggcttccaga
    13741 cccagcggtt cacccgaatg aatcagggac tcgatcacgc ggcggtgctg gttaactttg
    13801 atcggataaa caaggaagta atcgccgtta tagccgtagg attccctcgc acgtttgaac
    13861 gcggcgttaa tggaacgcaa acggtgctgc aggatctgtg ggaaacagaa cagtgcaggc
    13921 agacgctgac cctgtgcttc acgagttttc actaactgcg cgagatcgac gcgagcttcc
    13981 gggacgtccg ggtccgggca cacgctgatg tggcccagct cgttaacgtc atagtagtta
    14041 ttgccccacc aggcaatatt gtaagtacgc agcatcttgc tggcttcctg ggagctcatt
    14101 gcaacctcct gcatggagcg tagtacaccg tgttcgcccg ctgacgaagg caaacccata
    14161 gacatgtcgt cagacatagc gaacctcaaa ttattttatt aagtgtaaaa cagttaacga
    14221 ctgtcgcagc ctggaactgc gataacaacc cataagcaca tggattttcc agcagtgtat
    14281 gctgacgctc cgactgcgca accggtttct ttttcataac attattaagc acataaccga
    14341 acgtaagtgt gacagttcgg cgaaaccacg agaaaactct tgtttttaca agagcgccct
    14401 tgttcagtcc tcagtaactg taaccagctc ttgaatcctg agaagcgccg agatgggtat
    14461 aacatcggca ggtatgcaaa gcagagatgc agagtgcggg gaacgagtct tcaccagaac
    14521 ggtgagacag gttaagcagc agacaacggt tcattatttc gtatcacctc cacggccgcc
    14581 tgttaagacg aacccacaag ccaaaactct gatttcaacc cggctggaag tggcaacacg
    14641 aaagaaacgt cgtgtgcttt ttatttaagc cgcgcgccgc gttttatacc ccacaatggc
    14701 agaaaattgc aaaagataaa tacgcagaat gccggcattg tcaggaaaaa tttccagcca
    14761 cgtttttaac agaatgagac acgattcaaa aaaaagtgga aatcgggtga agaattgacc
    14821 taaaatagcc atccagatgt taatccatcc ataccgatta acactcagac tgccagtgtt
    14881 tttaacctgc agagtcgtgg taggatccgc taccacagaa aatccacaca acagtttgag
    14941 ctaaccaaat tctctttagg tgatattaaa tatggcaaaa caccttttta cgtccgagtc
    15001 cgtctctgaa gggcatcctg acaaaattgc tgaccaaatc tctgatgccg ttttagacgc
    15061 gatcctcgaa caggatccga aagcacgcgt tgcttgcgaa acctacgtaa aaaccggcat
    15121 ggttttagtt ggcggcgaaa tcaccaccag cgcctgggta gacatcgaag agatcacccg
    15181 taacaccgtt cgcgaaattg gctatgtgca ttccgacatg ggctttgacg ctaactcctg
    15241 tgcggttctg agcgctatcg gcaaacagtc tcctgacatc aaccaaggcg ttgaccgtgc
    15301 cgatccgctg gaacagggcg cgggtgacca gggtctgatg tttggctacg caactaatga
    15361 aaccgacgtg ctgatgccag cacctatcac ctatgcacac cgtctggtac agcgtcaggc
    15421 tgaagtgcgt aaaaacggca ctctgccgtg gctgcgcccg gacgcgaaaa gccaggtgac
    15481 tttccagtat gacgacggca aaatcgttgg tattgatgct gtcgtgcttt ccactcagca
    15541 ctctgaagag atcgaccaga aatcgctgca agaagcggta atggaagaga tcatcaagcc
    15601 aattctgccc gctgaatggc tgacttctgc caccaaattc ttcatcaacc cgaccggtcg
    15661 tttcgttatc ggtggcccaa tgggtgactg cggtctgact ggccgtaaaa ttatcgttga
    15721 tacctacggc ggcatggcgc gtcacggtgg cggtgcattc tctggtaaag atccatcaaa
    15781 agtggaccgt tccgcagcct acgcagcacg ttatgtcgcg aaaaacatcg ttgctgctgg
    15841 cctggccgat cgttgtgaaa ttcaggtttc ctacgcaatc ggcgtggctg aaccgacctc
    15901 catcatggta gaaactttcg gtactgagaa agtgccttct gaacaactga ctctgctggt
    15961 acgtgagttc ttcgacctgc gcccatacgg actgattcag atgctggatc tgctgcaccc
    16021 gatctacaaa gaaaccgcag catacggtca ctttggtcgt gaacatttcc cgtgggaaaa
    16081 aaccgacaaa gcgcagctgc tgcgcgatgc tgccggtctg aagtaatctt tcttcacctg
    16141 cgttcaaagg ccagcctcgc gctggccttt ttcttttacc tcaccgcggt ggataggcgt
    16201 tcacgccgca tccggcaaaa aaactgcccg cacaataaca tcattcttcc tgatcacgtt
    16261 tcacggcaaa ttaccatcac aactgaaacc gattacacca accacaccag caaaatattt
    16321 gtaatatttt catattatta ttcagctttc acagttgtta catttctttt cagtaaagtc
    16381 ttaattgcag atgacagcgt ttaatctatg atgatataac tcaattattt tcatgccctt
    16441 aaatcataac taagataaat gttagtgtaa gcgattacac tgatgtgatt tgcttcacat
    16501 ctttttacgt cgtactcacc tatcttaatt cacaataaaa aataactata ttggagggca
    16561 tcatgcctga cgctaaaaaa caggggcggt caaacaaggc aatgacgttt ttcgtctgct
    16621 tccttgccgc tctggcggga ttactctttg gcctggatat cggtgtaatt gctggcgcac
    16681 tgccgtttat tgcagatgaa ttccagataa cttcgcacac gcaagaatgg gtcgtaagct
    16741 ccatgatgtt cggtgcggca gtcggtgcgg tgggcatcgg ctggctctcc tttaaactcg
    16801 ggcgcaaaaa gagcctgatg atcggcgcaa tcctgtttgt tgccggttca ctgttctctg
    16861 cggctgcgcc aaacgttgaa gtactgattc tttcgcgcgt tctgctgggg ctggcggtgg
    16921 gtgtggcctc ttataccgca ccactgtacc tgtcagaaat tgcgccggaa aaaattcgcg
    16981 gcagtatgat ctcgatgtat cagttgatga tcactatcgg gatcctcggt gcttatcttt
    17041 ctgataccgc cttcagctac accggtgcat ggcgctggat gctgggtgtg attatcatcc
    17101 cggcaatttt gctgctgatt ggtgtcttct tcctgccaga cagcccacgt tggtttgccg
    17161 ccaaacgccg ttttgttgat gccgaacgcg tgctgctacg cctgcgtgac accagcgcgg
    17221 aagcgaaacg cgaactggat gaaatccgtg aaagtttgca ggttaaacag agtggctggg
    17281 cgctgtttaa agagaatagc aacttccgcc gcgcggtgtt ccttggcgta ctgttacagg
    17341 taatgcagca attcaccggg atgaacgtca tcatgtatta cgcgccgaaa atcttcgaac
    17401 tggcgggtta taccaacacc accgagcaaa tgtgggggac agtgattgtc ggcctgacca
    17461 acgtacttgc cacctttatc gcaatcggcc ttgttgaccg ctggggacgt aaaccaacgc
    17521 taacgctggg cttcctggtg atggctgctg gcatgggcgt actcggtaca atgatgcata
    17581 tcggtatcca ctctccgtcg gcgcagtatt tcgccatcgc catgctgctg atgtttattg
    17641 tcggttttgc catgagtgcc ggtccgctga tttgggtact gtgctccgaa attcagccgc
    17701 tgaaaggccg cgattttggc atcacctgct ccaccgccac caactggatt gccaacatga
    17761 tcgttggcgc aacgttcctg accatgctca acacgctggg taacgccaac accttctggg
    17821 tgtatgcggc tctgaacgta ctgtttatcc tgctgacatt gtggctggta ccggaaacca
    17881 aacacgtttc gctggaacat attgaacgta atctgatgaa aggtcgtaaa ctgcgcgaaa
    17941 tcggcgctca cgattaatct cctcaggctt cctcccgtcg cggaggaagc cgcctcttgc
    18001 agtcatcttt tcttcgctct atcctctgcc gctatgaaaa tatcccgtct ccctatcgcc
    18061 atccaacagg ccgttatgcg ccgcctgcgg gaaaaactcg cccaggccaa cctgaagcta
    18121 gggcgtaact acccggagcc aaaactctct tacacccagc gcggaacctc cgccggaaca
    18181 gcctggctgg aaagctatga aatccgcctc aatcccgttt tgctgttgga aaacagtgaa
    18241 gcttttattg aagaagtggt accgcacgaa ctggcacatt tgctggtatg gaaacatttc
    18301 ggccgcgtag cgccacatgg caaagagtgg aagtggatga tggaaagcgt gctgggcgtt
    18361 cccgcccgtc gtacgcatca gttcgaactg caatccgtgc gtcgcaacac cttcccctac
    18421 cgctgtaagt gccaggaaca tcagcttacc gtacgccgcc ataatcgcgt agttcgtggc
    18481 gaggccatct atcgctgtgt tcactgcggt gaacagctgg ttgcgaaata accacctgaa
    18541 ctatcaggaa ctttcctgat ctggctgatt gcataccaaa acaactttcg ctacgttgct
    18601 ggctcgtttt aacacggagt aagtgatgta ccgttatttg tctattgctg cggtggtact
    18661 gagcgcagca ttttccggcc cgacgttggc cgaaggtatc aatagttttt ctcaggcgaa
    18721 agccgcggcg gtaaaagtcc acgctgatgc gcccggtacg ttttattgcg gatgtaaaat
    18781 taactggcag ggcaaaaaag gcgttgttga tctgcaatcg tgcggctatc aggtgcgcaa
    18841 aaatgaaaac cgcgccagcc gcgtagagtg ggaacacgtc gttcccgcct ggcaattcgg
    18901 tcaccagcgc cagtgctggc aggacggtgg acgtaaaaac tgcgctaaag atccggtcta
    18961 tcgcaagatg gaaagcgata tgcataacct gcagccgtca gtcggcgagg tgaatggcga
    19021 tcgcggcaat tttatgtaca gccagtggaa tggcggcgaa ggccagtacg gtcaatgcgc
    19081 catgaaggtc gatttcaaag aaaaagctgc cgaaccacca gcgcgtgcac gcggtgccat
    19141 tgcgcgcacc tacttctata tgcgcgacca atacaacctg acactctctc gccagcaaac
    19201 gcagctgttc aacgcatgga acaagatgta tccggttacc gactgggagt gcgagcgcga
    19261 tgaacgcatc gcgaaggtgc agggcaatca taacccgtat gtgcaacgcg cttgccaggc
    19321 gcgaaagagc taacctacac tagcgggatt ctttttgtta acccctaccc cacgcgtaca
    19381 accgcgtggg gagacgacgc ggatttttaa ctatgcgtat cccccgcatt tatcatcctg
    19441 aaccactgac cagccattct cacatcgcgc tttgcgaaga tgccgccaac catatcgggc
    19501 gcgtactgcg catggggccg gggcaggcgt tgcaattgtt tgacggtagc aaccaggtct
    19561 ttgacgccga aattaccagc gccagcaaaa aaagcgtgga agtgaaggtg ctggaaggcc
    19621 agatcgacga tcgcgaatct ccgctgcata ttcacctcgg tcaggtgatg tcgcgtggtg
    19681 aaaaaatgga atttactatc cagaaatcga tcgaactcgg tgtaagcctc attacgccac
    19741 ttttttctga gcgctgcggc gttaaactgg atagtgaacg tctgaacaag aagcttcagc
    19801 agtggcagaa gattgcaatt gctgcctgtg agcagtgtgg tcgtaaccgg gtgccggaaa
    19861 tccgtccagc gatggatctg gaagcctggt gtgcagagca ggatgaagga ctgaaactga
    19921 atcttcaccc gcgcgccagt aacagcatca atacgttgcc tttaccggtt gaacgcgtcc
    19981 gcctgctgat tggcccggaa ggcggtttat cggcagatga aattgccatg actgcccgct
    20041 atcaatttac tgatatcctg ttgggacctc gcgttttgcg tacagagaca actgcgctca
    20101 ccgccattac cgcgctacaa gtacgatttg gcgatttggg ctaacggaga agaataatga
    20161 tcaagctcgg catcgtgatg gaccccatcg caaacatcaa catcaagaaa gattccagtt
    20221 tcgctatgtt gctggaagca cagcgtcgtg gttacgaact tcactatatg gagatgggcg
    20281 atctgtatct gatcaatggc gaagcccgcg cccatacccg cacgctgaac gtgaagcaga
    20341 actacgaaga gtggttttcg ttcgtcggtg aacaggatct gccgctggcc gatctcgatg
    20401 tgatcctgat gcgtaaagac ccgccgtttg ataccgagtt tatctacgcg acctatattc
    20461 tggaacgtgc cgaagagaaa gggacgctga tcgttaacaa gccgcagagc ctgcgcgact
    20521 gtaacgagaa actgtttacc gcctggttct ctgacttaac gccagaaacg ctggttacgc
    20581 gcaataaagc gcagctaaaa gcgttctggg agaaacacag cgacatcatt cttaagccgc
    20641 tggacggtat gggcggcgcg tcgattttcc gcgtgaaaga aggcgatcca aacctcggcg
    20701 tgattgccga aaccctgact gagcatggca cttgctactg catggcgcaa aattacctgc
    20761 cagccattaa agatggcgac aaacgcgtgc tggtggtgga tggcgagccg gtaccgtact
    20821 gcctggcgcg tattccgcag gggggcgaaa cccgtggcaa tctggctgcc ggtggtcgcg
    20881 gtgaacctcg tccgctgacg gaaagtgact ggaaaatcgc ccgtcagatc gggccgacgc
    20941 tgaaagaaaa agggctgatt tttgttggtc tggatatcat cggcgaccgt ctgactgaaa
    21001 ttaacgtcac cagcccaacc tgtattcgtg agattgaagc agagtttccg gtgtcgatca
    21061 ccggaatgtt aatggatgcc atcgaagcac gtttacagca gcagtaaccc accttagcga
    21121 gaaggatctc gttgagactc tgagtgacag cgcccttctt tccacgcata ctgggcgctg
    21181 ttgctttttt gaaccaggaa acagaacctc tgacaatgaa tttacagcat cactttctta
    21241 ttgccatgcc tgctctccag gatccgattt tccgtcgttc cgtggtctac atttgcgaac
    21301 ataataccaa tggtgcaatg gggatcatcg tcaacaagcc gctggaaaat ctcaaaattg
    21361 aagggattct ggaaaagctg aagatcacgc cggagccgcg tgatgaatca atccgtctgg
    21421 ataaaccggt tatgctcggc ggcccactgg ctgaagatcg cgggtttatt ttgcatactc
    21481 cgccctccaa ttttgcttcc agcattcgca tttcagacaa cacggtgatg accacttccc
    21541 gcgatgtgct ggaaacgctc ggcaccgata aacaaccgtc tgacgtattg gtggctctgg
    21601 gctatgcctc ctgggaaaaa ggtcaactgg aacaagaaat tctcgataac gcgtggctaa
    21661 cggccccggc ggatctgaat attctgttca aaacgccgat tgccgaccgc tggcgcgagg
    21721 cggcaaaact gattggtgtg gatattctca ccatgcctgg tgtggcagga cacgcctgat
    21781 gagtggaacc ttactcgcct tcgacttcgg caccaaaagc attggcgtag cggtcggcca
    21841 acgcattacc ggcaccgctc gccctttgcc tgcaattaaa gcgcaggacg gtacgccgga
    21901 ctggaacctc atcgaacgtt tactgaaaga gtggcagcct gacgaaatca tcgtcggttt
    21961 gccgctgaat atggacggca ccgaacagcc gttaaccgcc agagcgcgca aatttgccaa
    22021 ccgtattcat ggtcgtttcg gtgttgaagt aaagctccat gacgagcgtc ttagcactgt
    22081 ggaagcccgt tccggtcttt ttgaacaggg cggctatcgg gcgctcaaca aaggcaaagt
    22141 tgactctgcc tctgcggtta ttattctcga aagctatttc gagcagggat attaaggcga
    22201 tctaaaagcc tggcggatag tcgttaccgc catcttgccg gatgcggcgt gaacgcctta
    22261 tccagcacac atctggcagc ggctgtaggt ctgataagac gcgttagcgt cgcatcagac
    22321 atttattgcc tttataggcc ctataaactt gcgcatcggg catggcaacg tcacaaacgc
    22381 ccttccccca cccgctgctg ataactctgc tgaaacgtta acatccccac cttctgcccg
    22441 gtttgaataa catgcggtaa ctggtgggtt ttcccttcgc gaatcaaatt ccccaccgcg
    22501 ggagtgttaa tcagtaattc aaacagcgcc acgcgtcctt cctgtttatc cacttccagc
    22561 ttttgtgaca gcactgcccg taaactaccc gcaagttgat tacgtacggg atctttttcc
    22621 tgcgccggaa atgaatccac cagtcgctca actgcctgcg cggcaccacg tgtatgtaag
    22681 gttgccagca ccagatgccc ggtttctgcc gccgtcagcg ccagacggat tgtctcactg
    22741 tcacgtagct ctccgagcaa aatcacatca ggatcttccc gcaatgcagc ccgcaacccc
    22801 gatgcgaacg tcatacagtg caaaccaatt tcccgctgct ggatcaaaca tcgctggctg
    22861 gcatagagat attccacagg atcttccagc gtcagaatat gcgcatcggc atgttgatta
    22921 agatagccaa ccatcgccgc cagcgtggta gatttgccac tccccgtagc ccccgtcacc
    22981 agaatcaggc cattctcgct cttgagtaat tccggcaata ccggtggtgc accaagctgt
    23041 tcgagctgtg gacagtgcga aggtaacaac cgtaatgcca gagaaatacc ttgccgttgc
    23101 gcgaacgcac tgccacgcaa ccgctggttt tccgccagcg acacggcaaa atccagctgg
    23161 ccattttcca gcaatattgc ccgctgatcg tcatccagcc actcccgcag tagctcttcg
    23221 acgtccggcg catcaaacgg cgcagcttcc attctgccac gaatgcgcca tcgtgcgggc
    23281 caggcgctgc acaggtgtag atccgagacg ttatgcttta cactaagggc cacaatttct
    23341 tccatattca tactaagatc ctcggaaaat gaacgatatt gcgcataacc tggcacaggt
    23401 ccgggacaaa atctcagcgg ctgcaacgcg ttgcggccgt tctccagaag aaattacgct
    23461 gcttgcagtc agtaaaacaa aacctgcgag cgccatcgca gaagccattg atgccgggca
    23521 gcgtcaattt ggtgaaaact acgttcagga aggggtagat aaaattcgcc actttcagga
    23581 actgggcgta acaggattag aatggcattt tattggcccg ttgcagtcta ataaaagccg
    23641 cctagtggca gagcatttcg actggtgtca taccatcgac cgtttgcgca ttgctacccg
    23701 cctcaacgag cagcgcccgg cagaacttcc ccctcttaac gtactgattc aaattaatat
    23761 tagtgatgaa aacagtaagt ccgggattca actggcagaa ctggacgagc tggcagcggc
    23821 ggtcgctgaa ctaccgcgtt tacgtctgcg cgggctgatg gcaatccctg cgcttgagtc
    23881 agaatatgta aggcagtttg aagttgcacg ccaaatggct gtagcatttg ccggactgaa
    23941 aacgcgctac ccgcatatcg acacgctctc tctgggaatg tcggacgata tggaagccgc
    24001 cattgcggca ggtagcacga tggttcgtat cggcactgca atttttggtg cgcgtgatta
    24061 ctctaaaaaa taaggaatta aaggaacgcc atgaatacgt tgactttcct gctttcaacg
    24121 gtcattgagc tgtatacaat ggtgctgtta ttacgcatct ggatgcagtg tgctcat
//
