LOCUS       c00040_NZ_QRUP..       14632 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_QRUP01000006.1 Holdemania filiformis strain AF24-29
            AF24-29.Scaf6, whole genome shotgun sequence.
ACCESSION   NZ_QRUP01000006
VERSION     NZ_QRUP01000006
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 00:35:03
            Original ID  :: NZ_QRUP01000006.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 150113
            Orig. end    :: 164745
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14632
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[160113:164305]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14192
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14632
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14632
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(2399..3082)
                     /locus_tag="ctg40_131"
                     /transl_table=11
                     /translation="MEILSVQNCSRFYGRGALQIAALDHVSFTVNKGEFVAIVGPSGSG
                     KSTLMHILGGVDQPSEGQVVVDGTVITDLKEDKLAVFRRRQVGLIYQFYNLIPVLTVEE
                     NITLPLRLDGRKVDRDTVDQLLEQLGLTKQRNFLPSQLSGGQQQRVSIGRALIHHPAIL
                     LADEPTGNLDSRNTQEIMTLLRISNKQRNQTCIVITHDENIALQADRIIAIEDGRISSD
                     QVIRQ"
     CDS             complement(3161..4156)
                     /locus_tag="ctg40_132"
                     /transl_table=11
                     /translation="MRNREIKIFILGCIGLCLPFFLIAAAASREMLIVCVSLAAVLISA
                     FCLFTAWRYRRLRQLNDQMRRVREGLYQMNPQDYEEGELSILHSEIYKVTVQLRESAEQ
                     LQAQQQFLSDSLSDISHQLKTPLTSMMMMVDLMQQPDMDTVRQQEFLRLIAAQLTRMRW
                     LIQSLLKMAKLQAGAVQFLPNSITIRALINKALSQAEAEMLRNNVEWVLECPESFVLTV
                     DENWTAEALGNILRNCAEHAPNGQIRILCTRTALVDQIVIEDNGEGIDPQDLPHLFERF
                     YRGKNAKPDSVGIGLAMSQQILAAQAGTLSVESTPGRGSRFLIRFVRQVI"
     CDS             complement(4160..4846)
                     /locus_tag="ctg40_133"
                     /transl_table=11
                     /translation="MNKICCVEDDSAILTALQYTLSQEGYEVMTAMTKTQGLELIQQES
                     FDLVLLDVTLPDGSGYEICKRMREDSRLKEIPVIFLTACDDEVNIVMGLDLGADDYITK
                     PFRVRELISRMNSVLRRAGKKQAETTINYQDLSINTIAARVFKNNQEVFLTGMEYRLLL
                     ILATHRNQVMTRDQLFEAIWDLGGEYVNDNTLTVYIKRLREKLEDDPAHPQLIRTIRGL
                     GYKLGE"
     CDS             5029..5481
                     /locus_tag="ctg40_134"
                     /transl_table=11
                     /translation="MTKWKCFADSWKCSVILIAAILGCLFFLPEMRSIRQLMFAPAAIK
                     PQDFWDIQIQNSDNEQTEIIFQPYSYEEQTFFQALSERSCLLAEINDHPLQVIFPGQSI
                     KLHENDQIRLLWLVDPQLESQLKSRVIPDQALVFTHGQLQEDVDHE"
     CDS             5474..5809
                     /locus_tag="ctg40_135"
                     /transl_table=11
                     /translation="MNKKIRILNIFLSLILIGIVVVHFQFEVPALHFNQPIIEEWEDDF
                     ASGGGFGDALTDAIETAASNQDWQRAWQLSQLYAFVYARPDIQNGKLCWIDTAGGQRKT
                     VCGVLEP"
     CDS             5942..6310
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acetyltransf_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg40_136"
                     /sec_met_domain="Acetyltransf_1 (E-value: 2.5e-10,
                     bitscore: 33.8, seeds: 223, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTFQAAFEEEIDLIYQLYRRCVLTSRGSWDDEYPTRDFVEQDYL
                     RQGLMTLKNEQGEIVAAGAITPADELEDLEYRTALLHPLELSRLATDPQFQGRGYGKLL
                     LQGLMEEVRKRGLMEFSC"
     CDS             complement(6593..7495)
                     /locus_tag="ctg40_137"
                     /transl_table=11
                     /translation="METERLERILRQWLPGEEPIIIEEIHSGISSHARKIMCGETQGIF
                     REIASEAQAKTEAEFTAVLAPQGIAPGLKLTITKAAYVQDQGKFFNFQEYMQPSPDKPR
                     GVELAAHVGKTVARMQKVLFHKRMTLPVVPDRFALRQLKQKAQSRIAGFPTAVTAEHQA
                     AIHSLLQDSLIINLREDQPIHGDLGLWNMLWTTSGLRIIDFGEARLGDGYFDLAASLSS
                     CIQSEPDHALYPLMIEAFLNSYGDTYQAIDQSKLWAAIRFWLLRGVLAVISFQTPESWD
                     ALITKYLDFINELNTIFKP"
     CDS             complement(7563..8783)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M20"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg40_138"
                     /sec_met_domain="Peptidase_M20 (E-value: 3.7e-14, bitscore:
                     46.1, seeds: 360, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPEERLIRYAKINTVSDPESPTVPSSACQLDLLKVLKEEMEQLG
                     IQEVREDQGYLYGRIPSNLDYEVPTVGFIAHMDTAPDFCGEGVNPRMIAHYDGKDIALN
                     DKITLKVSDFPNMARYTGQDLIVTDGNTLLGADDKAGIADILTMAETLLTHPEIKHGEI
                     RIGFTPDEEIGRGADLFDVANFHADFAYTVDGGEMEAISDETFNAASAKVTVQGFSIHP
                     GSAKHKMINSLNVAMEFHAMLPVFNRPEYTEGTEGFNHLNNMEGNVEQTVMEYIIRNHD
                     SEQFQAQMATMKAAETYMNQKYGQPLVQVEIKESYRNMKEILKDQEWIVDLAKQAITEA
                     GLQPWVEKVRGGTDGARLTFMGLPCPNLGTGGANCHGRYEVCSVQEMHKVVEILLNIVK
                     ATTNLKK"
     CDS             complement(8780..9379)
                     /locus_tag="ctg40_139"
                     /transl_table=11
                     /translation="MKKRLDTSLLVWMNRPSLWTIGRSRIIFSTEPATDFWINQARQLN
                     KFNGHALLLPIRQDFTLTVTIRAQLHEVYDQLGIFVMSDPSCWCKAGIEYRDEQASSVC
                     STVTYGGFSDWAGMPISSGIHTLTLRLHRWQNEFRVEFSFNGQKFKWLREFALPFTEGV
                     AQVGFYACSPKDSTFDAEFFDMMIESLQWEEKRNKL"
     CDS             9552..10010
                     /locus_tag="ctg40_140"
                     /transl_table=11
                     /translation="MHYEADENELMNLVRSVNNHMNHVLNQFYSPYGLTRPQAIVLSEI
                     ERNGPVTVSLLAHRLGMTTSNLCLIAQRLEKSGFLKRKRDPQDQRSVILINTAKSHDLI
                     HQVQENVNEMIRQRLKYTDPENMDKIMEGLRLLNAVMIKQNQGDKACD"
     CDS             10001..12907
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg40_141"
                     /sec_met_domain="HGD-D (E-value: 5.1e-17, bitscore: 55.7,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 1.2e-34, bitscore:
                     113.2, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLGIDIGSTTIKYVVLDDAGRCIDQDYQRHSCQITEKLIEVLQR
                     VSAKYNQTAMALAVSGSAAMGLQEKCSLPFVQEVYATRIAATKRLEEVDCIIELGGEDA
                     KILFLSGGLEVRMNGTCAGGTGAFIDQMATLLNLSAEEMNEAAKQAEKIYTIASRCGVF
                     AKSDIQPLINQGADKEDLAASIYQAVVNQTIQGLAQGRKIEGHVVYLGGPLTFNSELRA
                     AFDKTLKLTGVCPENSLYYVAIGTALLAEEPVNFADAIEQLQTMDASSFVRSLPPLFAD
                     EDEYRRFSERHQRNQVRVHEPKEITGRCALGIDAGSTTVKMVLINEQEEILYSMYQPNQ
                     GNALQLVREALIELMRANPRMEIVSSCVTGYGEDLIRSAFGVDAGIVETMAHFTASRKY
                     MPDVDFIIDIGGQDIKCFKIHNGTIDNIFLNEACSSGCGSFLQTFANALGYEIEDFSRL
                     GLFAKHPVDLGSRCTVFMNSSVKQAQKDGATIDEISAGLSISVVKNALYKVIRTADARS
                     LGKHIITQGGTFYNDAVLRAFEQELDTEVIRPNIAGLMGAYGCALHALRHCPDASSLLN
                     LDQLEHFHNEIRYVQCGLCNNHCRLTVNQFSDGRKYIGGNRCERPVTKKSTAQDLNIYA
                     VKRELLSQYKPVPGPRGKIGLPLALNMMELLPFWHTFFTELGFEVVTSGFASLEKYQKA
                     QNSIPSDTICFPAKLVHAAIQSLLDQQIPAIFYPCMTYNMREKNADNNYNCPVVAYYPE
                     VIAANMQQVTQCDFIYDYVGIHRQKNFPVKVHKILNQHFRVGLREVIKASKKAYEAYDQ
                     HLETIRQKGQEIITQAQLDDREIIVLAGRPYHADPLVSHDIDKLITSYGAAVISEDVIN
                     EEVGKKELGVWNQWTYHSRLYAAARYVATQEKMNLVQLVSFGCGVDAITTDEVREILEE
                     HGKIYTQIKIDEITNLGAVKIRLRSLFAALKQEEEHHD"
     CDS             12900..14192
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg40_142"
                     /sec_met_domain="HGD-D (E-value: 1.9e-25, bitscore: 83.5,
                     seeds: 370, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDNKVLFTKEMQKDYTILIPMMAPIHFQLLRNVLVHSRYNVELL
                     ENTGPSVVEQGLKYVHNDTCYPALLVIGQMIDALKSGKYDVHKTALIITQTGGGCRASN
                     YIYLLRKALKKADLGFVPVISLNLSGLDSQPGFKLSLSMLQKMLCALVYGDLLMDLTNQ
                     VRPYEVTSGTADQLCQHWIDDLSRQFNRRQGLSIGDMKRNMRDIVMSYAAIEREKRDLV
                     KVGIVGEIYIKYSPLGNNSLEKFLAEQQCEVKLPGMMGFMLYCVYNGVEDVKLYGGGFV
                     KKQLMSFVYSLVLKLEKMTIDAIRTYSDFEVPGSFPEMKAGAEQIIGLGAKMGEGWLLT
                     GEMVELNKAGFKNIICTQPFGCLPNHIVGKGMIRKIREQDPDCNIVAIDYDPSATQVNQ
                     ENRIKLMLSIARENMKKAETDTVSIPVPEAE"
     CDS             14412..14630
                     /locus_tag="ctg40_143"
                     /transl_table=11
                     /translation="MTLIKAKKQRSKPQAPSNYKLRCTNDFVFKSLMTYDPEIGKRLVK
                     DLTESIRDYVVDKVDLTSTELLTEGFQA"
ORIGIN
        1 aaagtgatca gatacagact gacaggaatg ccgatggctg ccgcgcccag tccgtaaaac
       61 agactttcaa gccggatcat acgattgaat ttcttttcat ccatgcccac tgaccgcagc
      121 atcgcaaact ccttgcgccg cagcccgatg ttggtcgaga tcgtattgat aacgttgacc
      181 aggcagatca tgcagatcaa ggtgataaat ccgtagataa agatggaaac aatcgtcagc
      241 agcgttttat cttcccgctg attctgaacc ggactgtacc agctgaagct gtgcgtaaga
      301 ttctgcttgc caatttcatc gatctgctgg atcatcgttt cctgctgtcc cggaactgcc
      361 cgcaggtaca gcttatcgct gtaagaccgt gaacctttcg cttctgtcag aagcgtattc
      421 agatttgaaa ccggaatcag caccgcaagg ttgccgccgt atacgatttc gctggaatac
      481 agatccatgt ccgcggcgag cgccatcggt tttatcgtca gcgtttctcc cgcgtcgccg
      541 atcgagatct tcaaggtttc cggcatgctt tgcaagaacg gaacgtccgc ataccgtttt
      601 ttcccgttct ccgtgatctg cgctcgataa cggttaaaga ggattcccgg gatcacgtcg
      661 tcggcaggat ctgccatcat cgcttctgaa atttgatttt cagccagaat ttgtgcgtat
      721 gattcatcat ccaccgcaaa caacagcgcc ggatattctt ccccaatccc tgaccagtag
      781 tcgtcgaagt caagattctg cgtatgcacg gcggcataca cctgggtaat ccgctgggtg
      841 ccggcaactg aagtcagctg gcgaagctgg gtgaagctgg gcttttcttc gagaaaggaa
      901 tgcgaagaat aatccgtgac ccaggcgtca gcgagttcat cctgactggt catgcccacg
      961 gcctgaatca tcattgtcat aatcgaggtc accgtcgtaa acagaatcaa gctgaccgcc
     1021 agcgataaaa tggtcagtcc ggctttgcgg ccgctgcgct ggatattttt gacagccaat
     1081 tcgccctcga caccccacaa ttttcccgcg acgaaggaga agaagcgatg gcggcgtttc
     1141 agcttcactt tctgcggctg acgaatcgcc tggatcggcg tcatccgcgc ggcttttaag
     1201 gccggcagcc aacaggcaag gacgatcatc actacggaac aaattaccgt caaggcaacc
     1261 gcgggaaagg aaaccaccgt atgaaacgga acatcggcgg aaaggaattc caacgattga
     1321 agcattggat taatcacgcg cagcgttacc gccattccgc agatccccgc cagcacgcct
     1381 aacggtatgg ccgccagcgc gatcatcagc ccttcctgaa ccacacacca gaatttctga
     1441 cgagaagtcg cgccgacact ggccagaatc ccgaactgcc ggctgcgttc agtcagtgaa
     1501 atcgcgaatg cgttataaat cagaaatacc gatccagtga tgataatgaa caatgtcagc
     1561 gtcgccgctg aggcgaccat ggcgaaataa ctgttttccc agaatggacc gcgaaaccgc
     1621 aggacgttgt tattcacccc tgcagccgga tacagcttga tctgaagctg cggaaaatct
     1681 tcctgcggcc gctgaccgga atattttaat ttaacatata caaccggatc cacaccggga
     1741 ttcgtttcgg aacgggacgt gatcgcggta taacccggcg accagcgcgg ttccagatcc
     1801 gaacgttcca tgattccaac cacagtgtaa tttcgcggct gcggatcagc gatcgtttcc
     1861 ggctgttccg gatcgtaagg attgttttga tttaacggct gatccggact ttcctgcagc
     1921 acccgctggc ctgtctgcag cgtaatcgtc tgacccagtt caatttcaac gccgccattg
     1981 taggcaacat gctcggaaac caacagctcg ttttcatttt ccggcagccg tccggagact
     2041 aaatgcaggc caagccgctg gaaaccttcc tcgtcgcagg cccggataaa ccaatacggc
     2101 ttgtattcgt tctgactttc cggtaagacg gcatagccca gatcatcaac cgtaaaggtg
     2161 tgatccacct gtttatccgt atttaaatac tgaatttcag tttcattcag atcgctgtaa
     2221 gccagctccc agtcgcccgt ttcatagatt gccttgcgtt ccatataatc aagaaacgag
     2281 gaagcgaaca cgctgacagc cgtgatcatc gcgacagaaa tgacgatccc catccccgta
     2341 aacaatgtgc gccggcggtt aaccttcagc gattgaaagg tatattgatg caggatattc
     2401 attgccggat cacctgatcg gaactgatcc gtccgtcttc aatcgcgatg atgcggtcgg
     2461 cctgcagcgc gatattttca tcatgggtga tgacgatgca ggtctgattg cgctgcttgt
     2521 tcgatattct cagcagcgtc atgatctcct gagtgttgcg gctgtccaga ttgccggtcg
     2581 gctcatccgc aagcaggatc gccggatgat gaatcagcgc tcttccgatc gacacccgct
     2641 gctgctgccc gccggaaagc tggctgggca gaaaattccg ctgtttggtt aatcccagct
     2701 gctctaacag ctgatcgacc gtgtcccggt cgactttacg cccgtccaga cgcagcggca
     2761 gcgtaatatt ctcctcgacc gtcagcaccg gaatcaaatt gtaaaactga tagatcagac
     2821 cgacttgacg gcggcggaac accgccagct tatcttcctt taagtccgtg atcaccgttc
     2881 cgtcgacgac gacctgacct tcgctgggct gatcgacgcc gcccagaata tgcatcagcg
     2941 ttgattttcc tgatccggaa ggtccaacaa tcgcaacgaa ttcgccttta ttcaccgtaa
     3001 aactgacatg atccagcgcc gcgatctgca gcgctccgcg gccgtaaaac cggctgcagt
     3061 tttgcacgct taatatttcc atgagtattc ctcctgacac aatcaatata aacgaaacgg
     3121 atgacacgcc gatgaaaccg cggatgacaa attcgtcatg ttaaatcacc tggcggacaa
     3181 accggattaa aaaccgcgat ccccggcccg gcgtactttc cacgctgagc gtcccggcct
     3241 gtgcggctaa aatctgctgg gacatcgcca agccgatacc gacgctgtcc ggcttcgcat
     3301 ttttaccacg gtaaaaccgt tcaaataagt gcggcagatc ctgcggatcg atcccctccc
     3361 cgttgtcctc gatcacaatc tgatcgacca gagctgtgcg cgtacagaga atccggatct
     3421 gtccgttggg cgcatgttcg gcgcagttgc gcagaatatt ccccagcgct tccgccgtcc
     3481 agttttcatc gaccgtcaaa acaaacgatt ccggacattc cagcacccat tccacattat
     3541 tccgcagcat ctccgcttcc gcttgggaca gcgccttgtt aatcagggcg cggatcgtta
     3601 tggaattggg caaaaactgc accgctcccg cctgcagctt cgccattttg agcagtgact
     3661 gaatcagcca gcgcatccgc gtcagctgag cggcgatcaa gcgcagaaat tcctgctgcc
     3721 gaaccgtatc catgtccggc tgctgcatca gatcgaccat catcatcatt gaggtcagcg
     3781 gtgttttcag ctgatgagaa atatcgctga gcgaatcgga aagaaactgc tgctgcgcct
     3841 gcagctgttc cgcactttcc cgcagctgaa ccgtcacctt atagatctcg ctgtgcagaa
     3901 tactcagttc cccttcctca taatcctgcg gattcatttg ataaaggcct tcccggaccc
     3961 tgcgcatctg atcgttcagc tgccgtagcc ggcggtagcg ccacgccgta aacagacaga
     4021 acgcactgat caaaacagcg gccaggctga cacagacaat cagcatctcc cgggacgccg
     4081 ctgcggcgat cagaaaaaag ggcaggcata atccgatgca gcccaggata aaaattttga
     4141 tttcacgatt tcgcatctgt cattccccca gtttgtagcc taacccccgg atcgtccgga
     4201 tcagctgcgg atgcgccgga tcatcctcca gcttttcccg cagccgttta atataaaccg
     4261 tcagcgtatt gtcattgacg tattccccgc ccagatccca gatcgcttca aacaactggt
     4321 cgcgcgtcat gacctgattg cggtgcgtcg ccaaaattaa taaaagccgg tattccatgc
     4381 ctgtcagaaa gacttcctga ttattcttaa acacccgcgc agcgatcgta ttgatgctta
     4441 aatcctgata gttgatcgtc gtttcggcct gtttttttcc ggccctgcgc aatacggaat
     4501 tcatccggga aatcagctca cgcacgcgaa atggcttcgt gatgtaatcg tccgccccca
     4561 gatccagccc catgacaata ttgacctcat cgtcgcaggc cgtcagaaaa atcactggaa
     4621 tttctttcag ccgggagtcc tcgcgcatcc gcttgcagat ctcatagccg ctgccatccg
     4681 gcagcgtcac gtccagcagc accagatcaa agctctcctg ttggatcaac tccagcccct
     4741 gcgtcttggt catcgcggtc atgacctcgt agccttcctg actcagcgta tattgcagcg
     4801 ccgttaagat cgcgctgtca tcctctacgc agcaaatttt attcatgttt atcacctggt
     4861 tttattataa ccgatctaac cgcctgacac atgacgagtt cgtcactttg aaactgacaa
     4921 tttcatgacg attgtcccgg gccgattgtt gtcggcttgg atttccttta taatagcctt
     4981 aagttaaggg gccatcaata gacttagaaa aagaaagaag gcgtcatcat gacaaagtgg
     5041 aaatgttttg cggacagctg gaaatgttcg gtaattctga tcgcagcgat tttaggctgc
     5101 ttattttttc tgccggagat gcgcagcatc cgccagctga tgtttgcccc tgccgccatc
     5161 aagccgcagg atttctggga tattcaaatt caaaactctg acaacgaaca aactgagatc
     5221 atctttcagc cgtattccta tgaggaacaa acgtttttcc aggcgttaag cgaacggagc
     5281 tgtctgcttg cggaaatcaa tgatcatccg cttcaggtga tatttcccgg gcaatccata
     5341 aaactccatg aaaatgatca aatccgcctt ctctggctgg tcgatcctca attagaatct
     5401 cagcttaaat cgcgtgtgat tccagatcaa gccctggttt tcactcacgg ccagctgcag
     5461 gaggacgttg atcatgaata agaaaatacg gattctgaat atttttttaa gcttgatctt
     5521 aattggaatt gtcgttgttc actttcaatt tgaagttccc gcactccact tcaaccagcc
     5581 gattatcgag gaatgggagg atgacttcgc cagcggcggc ggcttcggcg acgcgcttac
     5641 cgacgcgatc gaaaccgcgg ccagtaatca ggattggcag cgggcctggc aactgagcca
     5701 gctgtacgct ttcgtttatg ccagaccgga cattcaaaac ggaaaactgt gttggattga
     5761 caccgcgggc ggacaaagaa aaacggtctg cggagtttta gaaccgtagc gattcaggta
     5821 cccgattctc ttcattggct attcacttcc tattcagcag ttgataaaca agacacattg
     5881 taagaacccc ctattttgta aaaaaacatt ccattcatta ttgaaagaag gacaacgcat
     5941 gatgcttact tttcaagccg ctttcgaaga agaaatcgat cttatttacc agctgtatcg
     6001 acgttgtgtt ctaacaagcc gcggcagttg ggatgacgaa tacccgaccc gagattttgt
     6061 ggaacaggat tatcttcgcc agggattaat gactttgaaa aacgaacagg gcgagatcgt
     6121 cgcggcgggt gcgatcacac cggcggatga actggaagat ttagaatacc gcacggcttt
     6181 gcttcatcct ctggaattaa gccgtttagc aacagatccg cagtttcagg ggcggggata
     6241 tggtaagctc ctgctgcaag gtttaatgga agaagtacgc aaacgggggc tgatggaatt
     6301 cagttgttag cggccaaaga aaacgcaccg gccctggcct tgtatcgcgg cgctgatttt
     6361 caagagaaag gcagctgccg gatgtacgat actgacttca tcctgtttga aaagaaattg
     6421 taaaagaaga taaagctcaa aaaaacagga agtccacgtc tgcctcagcg gtcagattga
     6481 cttcctgttt tatttttatc gttgtcagaa caggcagacc taaaatccaa cttcccgtca
     6541 accagatgat aggtctgccg atggcgaatc agacagggaa gagaaaacga actcacggct
     6601 tgaaaatcgt gtttaattca ttgatgaaat ccagatactt tgtgatcaga gcatcccagc
     6661 tttccggagt ttgaaagctg atgacggcta acacaccccg tagtaaccag aaacggatcg
     6721 cggcccatag tttggattga tcaatcgctt gatatgtgtc gccataactg ttcaaaaagg
     6781 cttcgatcat taaaggatac agcgcgtggt cgggttcgct ttgaatacaa gaggaaagac
     6841 tggcggctaa atcaaaataa ccatcgccca gccgggcttc gccaaaatca ataattcgca
     6901 gacccgaggt tgtccaaagc atattccaca atcccaaatc tccgtgtatc ggctgatctt
     6961 cacgcagatt gattatcaag ctgtcctgaa gcaaactatg aattgcagcc tgatgctcag
     7021 ctgtgaccgc cgtcggaaat cctgcgatcc ggctttgggc tttttgcttc agctgtctta
     7081 aagcaaaccg gtcaggaaca actggcagag tcatccgctt gtggaacaaa actttctgca
     7141 tccgtgccac ggtctttcct acatgcgcgg ccagttccac gccccgtggt ttatctggcg
     7201 aaggctgcat atattcctga aagttaaaga atttcccttg gtcctgaaca taagcagctt
     7261 ttgttattgt gagcttaaga ccaggtgcaa ttccctgcgg cgccaaaaca gcggtgaatt
     7321 ccgcttccgt cttggcttga gcttccgacg cgatttccct gaaaattccc tgagtttcac
     7381 cgcacatgat cttgcgggca tgactggaaa taccactatg aatttcttct attattattg
     7441 gttcttctcc cggcagccac tgccgaagaa ttctttctaa tcgttctgtt tccatcgatg
     7501 ttccctcatc tttagttgat cgtgtaaaaa gctgaaccct tacgattcag ccttttcatt
     7561 ttctatttct ttaaattcgt cgtcgctttt acgatgttca gcagaatctc taccaccttg
     7621 tgcatctcct gcacgctgca tacttcgtaa cggccatggc agttcgcccc gccggtcccc
     7681 aagttcggac atggcagacc catgaacgtc agccgcgctc catcggtgcc gccgcgaact
     7741 ttttccaccc atggctgcaa acccgcttct gtgatcgcct gtttcgccag atctacaatc
     7801 cattcctgat ccttcaggat ttccttcata tttcgatacg attccttaat ctccacctgc
     7861 accagcggct gtccgtattt ctgattcata tacgtctccg ccgccttcat cgtggccatc
     7921 tgcgcctgga actgctcgct gtcatgattg cggatgatat attccatcac cgtctgttca
     7981 acattgccct ccatattgtt cagatgatta aaaccttcgg tcccctcggt atattccgga
     8041 cggttgaaca ccggcagcat cgcgtggaat tccatcgcga cgttcaggga attgatcatc
     8101 ttgtgcttcg cgctgcccgg atggatcgag aagccttgaa ccgtgacctt cgcgctggct
     8161 gcgttgaacg tttcatcact gatcgcttcc atctcgccgc cgtcaaccgt atacgcgaaa
     8221 tccgcgtgga aattcgcaac gtcgaacaaa tccgcaccgc ggccgatttc ctcatccggc
     8281 gtaaagccga tccggatctc gccatgcttg atttccggat gcgtcagcag cgtttccgcc
     8341 atcgtcagaa tatctgcgat gcccgcttta tcatctgccc ccagcagcgt attgccgtcg
     8401 gtaacgatca gatcctgacc cgtatatcgc gccatattcg ggaaatcgct gaccttcagc
     8461 gtaatcttgt cgttcagtgc gatatccttg ccgtcgtaat gagcaatcat ccgcggattg
     8521 acgccttcgc cgcagaaatc cggcgcggta tccatgtgcg cgataaagcc gacggtcggc
     8581 acctcatagt ccagattcga cgggattctg ccgtacaaat agccctgatc ctcccgaacc
     8641 tcctggatgc ccagctgttc catttcttct ttcaatacct ttaacagatc cagctgacag
     8701 gccgagctgg ggacggtcgg actttccgga tccgaaaccg tgttgatttt cgcatagcga
     8761 attaaacgct cttctggggt cataatttat tcctcttttc ttcccattgc aggctttcaa
     8821 tcatcatatc aaaaaactca gcgtcaaacg tcgaatcctt gggactgcag gcataaaacc
     8881 caacctgtgc gacaccctcg gtgaacggca gcgcaaactc ccgcagccat ttgaatttct
     8941 gaccgttaaa cgaaaattcg acgcggaatt cattctgcca ccgatgcagc cgcagcgtca
     9001 gcgtatgaat gccgctggag atcggcatgc cggcccagtc agagaaaccg ccgtacgtca
     9061 ccgttgaaca gaccgacgac gcttgttcgt cgcgatattc aattcccgcc ttgcaccagc
     9121 aggaaggatc gctcatgaca aaaatcccca gctgatcata aacttcatgc agctgcgcac
     9181 gaatcgttac cgtcaatgtg aaatcctgac ggatcggaag caagagcgca tgcccgttga
     9241 atttattcag ctgacgggcc tggttgatcc agaaatccgt cgccggttct gtactgaaaa
     9301 tgatccggct gcgtccgatc gtccataagg acggacggtt catccagacc agcagcgaag
     9361 tatccagccg ttttttcata cttatccttc ctaactattt ttattatatc aaattccccg
     9421 gcaaataggt ttttgaaagt gaaaagaaga tgaaaagaag acgaatttca ggcaatcgaa
     9481 ttgacttttt tatttaaatg gttaatattt aatgcattaa ttatttaaaa tcaaggattg
     9541 gggatgactg tatgcactat gaagccgatg aaaatgagct tatgaatctt gtacggagtg
     9601 tgaacaatca catgaatcac gtattaaatc agttctattc accctacggt ttaacacgtc
     9661 cgcaggcgat agttctttcg gaaattgaac gaaatggccc ggttaccgtc agtcttctgg
     9721 cgcatcgtct gggcatgacc accagcaatc tctgcctgat tgcgcagcgg ctggagaaaa
     9781 gcggcttctt aaagcgaaaa cgggatccgc aggatcagcg cagcgtgatt ttgatcaaca
     9841 ccgccaaaag ccacgacctg atccatcagg tacaggaaaa cgtcaatgaa atgatccggc
     9901 agcggctgaa atacaccgat cccgaaaata tggataagat aatggaggga ctgcggttgt
     9961 taaacgccgt catgataaaa cagaatcagg gggacaaagc atgcgattag gaatagatat
    10021 tggttcgacg acgatcaaat atgtcgtcct ggatgacgcg ggacgatgca ttgatcagga
    10081 ttatcagcgg cacagctgcc agatcacgga aaagctgatc gaggtgctgc agcgtgtatc
    10141 tgccaaatac aatcagacgg ccatggcgtt agccgtgtcc ggctccgccg cgatgggcct
    10201 gcaggaaaaa tgcagcctgc cgtttgtgca ggaagtgtac gcgacccgga ttgccgcgac
    10261 gaaaagactc gaggaagtcg actgcatcat cgagctgggc ggcgaagacg cgaagattct
    10321 gtttctcagc ggcggtctgg aagtccggat gaacggcacc tgcgccggcg gtacaggcgc
    10381 gtttatcgat cagatggcca cgcttttaaa cttaagcgcg gaagaaatga acgaagccgc
    10441 taaacaggcg gagaagatct acacgatcgc ctcccgctgc ggcgtgttcg ccaagtcgga
    10501 tatccagccg ctgatcaacc agggcgcgga taaagaggac ctggccgcca gtatttatca
    10561 ggcggtcgtc aatcagacga tccagggact ggcgcagggg cgtaaaatcg aaggtcatgt
    10621 cgtctatttg ggcggaccgc tgaccttcaa cagcgagctg cgcgcggcgt ttgataaaac
    10681 attgaagctc accggcgtct gtccggaaaa cagtctgtat tacgtcgcga tcggcaccgc
    10741 gttattagcg gaagaaccgg tgaatttcgc cgacgccatc gaacagctgc agacaatgga
    10801 cgcatccagc tttgtccgtt ccctgccgcc gttgtttgcg gacgaggacg aataccgccg
    10861 gttcagcgag cggcatcagc gcaatcaggt ccgggttcat gaaccgaaag aaattaccgg
    10921 ccgctgcgct ttgggcatcg acgccggcag cacgacggtc aaaatggtgc tgatcaacga
    10981 acaggaagaa atcctgtatt cgatgtatca gcccaaccag ggcaacgcgc tgcagttggt
    11041 ccgggaagcg ctgatcgaat tgatgcgcgc caacccgcgg atggaaatcg tgtccagctg
    11101 cgtcaccggc tatggcgaag atctgatccg cagcgccttc ggcgtcgacg ccggcatcgt
    11161 ggaaacaatg gcgcatttca ccgccagccg caaatatatg ccggacgtcg acttcatcat
    11221 cgacatcggc ggtcaggata tcaaatgctt taaaattcat aacggcacga tcgacaacat
    11281 cttcctgaac gaagcctgtt ccagcggctg cggcagcttc ctgcagacgt tcgccaatgc
    11341 gctgggctat gaaatcgagg atttctcgcg gctcggcctg ttcgccaaac atcctgtcga
    11401 tctgggcagc cgctgcacgg tcttcatgaa ttcctcagtc aagcaggcgc agaaggacgg
    11461 ggcgacgatc gacgaaatct ccgcgggtct gtcgatcagc gttgttaaaa acgccttgta
    11521 taaagtcatc cggaccgccg acgcgcggtc tctgggcaaa catatcatca cccagggcgg
    11581 caccttctac aacgacgcgg tgctgcgggc cttcgagcag gaactcgaca ccgaagttat
    11641 ccggccgaac atcgccggtc tgatgggcgc ttacggctgc gcgctgcatg ccctgcgcca
    11701 ttgcccggat gcatcgtcgc tgctgaatct tgatcagctg gaacacttcc acaacgaaat
    11761 ccgctatgtc cagtgcggtt tgtgcaacaa ccattgccgg ctgaccgtca accagttttc
    11821 cgacggccgc aaatatatcg gcggcaaccg ctgcgaacgc ccggttacga aaaaaagcac
    11881 ggctcaggac ttaaacatct acgccgtcaa gcgcgagttg ttaagccagt acaagccggt
    11941 tcccgggccg cgggggaaaa tcggcctgcc gttagcctta aatatgatgg agctgcttcc
    12001 attctggcac accttcttca cagagctggg cttcgaggtc gtcacctccg gcttcgcttc
    12061 gctggaaaaa taccagaaag cgcagaactc aattccttcc gacacgatct gcttcccggc
    12121 caaactggtt cacgccgcga tccaatcgct gctcgaccaa cagatcccgg cgattttcta
    12181 tccgtgcatg acctacaaca tgcgtgaaaa aaatgccgac aacaattata actgtccggt
    12241 cgtcgcttac tatccggaag tcatcgccgc caatatgcag caggtgacgc aatgtgattt
    12301 catctacgat tatgtcggca ttcaccgtca gaagaatttc ccggtcaagg ttcataaaat
    12361 cctgaaccag cacttccgcg tcggtctgcg cgaggtgatc aaggccagca agaaggcgta
    12421 tgaggcttat gatcagcatc tggaaacaat ccggcaaaaa gggcaggaaa tcatcacgca
    12481 ggcgcagctg gatgatcgtg aaatcatcgt gctggcaggc cggccgtatc atgccgatcc
    12541 tctggtttcc catgatatcg acaaactgat caccagctac ggcgcagcgg tcatcagcga
    12601 ggatgtcatc aacgaggaag tcggcaagaa ggagctgggc gtctggaacc aatggacata
    12661 tcactcccgg ctgtacgccg cggcccgcta tgtcgcgacg caggaaaaga tgaatctggt
    12721 gcagctggtt tccttcggct gcggcgtcga cgcgatcaca actgacgaag tgcgggagat
    12781 tcttgaggaa cacggcaaga tttacacgca gatcaaaatt gacgaaatca ccaacctggg
    12841 cgcggtcaaa atccgtctgc ggtccctgtt cgccgcgctg aagcaggagg aagaacatca
    12901 tgactgacaa taaagtttta ttcacgaaag aaatgcagaa ggactatacg atcctgattc
    12961 cgatgatggc gccgatccac ttccagctgc tgcgcaacgt gctggtccac agccggtaca
    13021 acgtcgagct gttggaaaac accggtcctt cagtcgtcga gcagggtctg aaatatgtcc
    13081 ataacgatac gtgttatccg gcgctgctgg tcatcggtca gatgatcgac gcactgaaaa
    13141 gcggaaaata cgacgttcac aagacggcgc tgatcatcac ccagaccggc ggcggctgcc
    13201 gcgcgagcaa ttatatttat ctgctacgca aagccttgaa aaaagcagat ctcggctttg
    13261 tcccggttat ttccctgaat ttatcgggat tagattccca accgggtttt aaattaagcc
    13321 tgtcgatgct gcagaagatg ttgtgcgcgc tggtctatgg cgatctgttg atggatctga
    13381 ccaatcaggt acggccgtat gaagtgactt ccggcactgc cgatcagctt tgccagcact
    13441 ggattgacga cctcagccgc cagtttaacc gccgtcaggg cttatccatt ggggatatga
    13501 aacgcaatat gcgcgatatc gtcatgtctt acgccgcgat tgagcgggaa aaacgggact
    13561 tagtcaaggt cggcatcgtt ggtgaaatct atattaaata ttcgccgctg ggcaacaaca
    13621 gcctggagaa gttcctggca gagcagcaat gtgaggtaaa gctgccgggg atgatgggct
    13681 tcatgttgta ctgcgtctac aacggcgtcg aagacgtcaa gctgtacggc ggtggtttcg
    13741 tcaaaaaaca gctgatgagt ttcgtctatt cgctggtgct gaaactggag aaaatgacga
    13801 tcgacgcgat ccgcacttat tccgattttg aagtgccagg ctcatttccg gaaatgaaag
    13861 cgggcgctga gcagattatc ggtctggggg cgaagatggg cgagggctgg ttattgaccg
    13921 gcgagatggt tgaattgaat aaagcagggt ttaaaaatat tatctgtacc cagccgtttg
    13981 gctgtctgcc gaatcatatc gtcggcaaag gcatgatccg caaaatccgc gaacaggatc
    14041 cggactgcaa catcgtcgcg atcgattatg acccaagcgc aacacaggtc aatcaggaaa
    14101 accggattaa actgatgttg tccatcgcgc gggaaaatat gaaaaaagca gaaactgaca
    14161 cggtatccat acctgtaccc gaggctgagt agctcaaatt tcaatataac gcaagaaggc
    14221 tgaatccgcc ttcttttttt atctttagct tccttatctt agcgttgttt tgttttgatt
    14281 tctatttggg atccgcgacc tttacagctt gtgaaaaaga accttcattc tgtgaaaaaa
    14341 tgatgaaaaa tgaagaaata acggggcttt tcgcaaaaaa gcgcaatagg tataagggag
    14401 ggataaaacc tatgacttta ataaaagcga aaaagcaacg ttccaaacct caggctccat
    14461 ccaactacaa gctgcgctgt acgaatgact ttgtgttcaa atccctgatg acttatgatc
    14521 cggagattgg aaaacggctg gtaaaagatc tgaccgaaag tatccgggat tatgtcgtag
    14581 acaaggtcga tctgacttct acggagctgt tgaccgaagg cttccaggcc aa
//
