LOCUS       c00025_NZ_JAGZ..       15979 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_JAGZTV010000013.1 MAG: Klebsiella sp. isolate
            L2_037_016G1_dasL2_037_016G1_concoct_2 L2_037_016G1_scaffold_27,
            whole genome shotgun sequence.
ACCESSION   c00025_NZ_JAGZ..
VERSION     c00025_NZ_JAGZ..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 01:28:45
            Original ID  :: NZ_JAGZTV010000013.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 157827
            Orig. end    :: 173806
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15979
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[167827:169500]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..11673
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..15979
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15979
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             complement(741..2330)
                     /locus_tag="ctg25_133"
                     /transl_table=11
                     /translation="MTLPFKPHLLALLCSAGLLAAAGTLYVKSREPQTVPEPPAVAQTA
                     QATAAAQPVATTYTSAQIDQWVAPIALYPDNLLSQVLMASTYPSNVVQAVEWSQDNPTM
                     KGDAAVQAVANQPWDPSVKSLVAFPSLLALMGENAPWVENLGNAFLAQPQAVMDSVQRL
                     RAIAQQTGTLKSTPQQKVITATRSAAPAPATSTATASRSSSAVTSSAPAQVIKIESTNP
                     NVVYVPAYNPSVVYGAWPDTAYPPVYLPPPPGEQFTDSFVKGFGYSLGVATTYALFSSI
                     DWDDDDHHHHDDDDHHHDDDHHGGYTHNGDNININVNNFNHITGQNLPGNRASWQHNPA
                     YRGNIPYPDNTIAQHYHQTNVPGGLSATQHQPADRNAQRQAAMTQLQQRTGPADNALNH
                     APSRDAQRQAASQQLHQVTQRNNYRGYDATPAVKNSAVQQQHREAAKTIQHPTTQQQQR
                     REQFRAATPEQRQQKLNNLHANALSGNDIRSPSWQSQQERGLQSRHISGLSSEQRSAAR
                     EHLSEHRELRRR"
     CDS             2686..5283
                     /locus_tag="ctg25_134"
                     /transl_table=11
                     /translation="VLEEYRKHVAERAAEGIVPKPLDATQMAALVELLKNPPAGEEEFL
                     LDLLINRVPPGVDEAAYVKAGFLAAIAKGEATSPLVTREKAVELLGTMQGGYNIHPLID
                     ALDDAKLAPIAAKALSHTLLMFDNFYDVEEKAKAGNAYAKQVMQSWADAEWFLSRPQLA
                     DKITVTVFKVTGETNTDDLSPAPDAWSRPDIPLHALAMLKNAREGIDPDQPGAVGPIKQ
                     IEALQQKGFPLAYVGDVVGTGSSRKSATNSVLWFMGDDIPHVPNKRGGGLVLGGKIAPI
                     FFNTMEDAGALPIEVDVNNLNMGDVIDVYPFKGEVRNHETGELLATFELKTDVLIDEVR
                     AGGRIPLIIGRGLTTKAREALGLPHSDVFRQAKDVAESSRGYSLAQKMVGRACGVAGVR
                     PGAYCEPKMTSVGSQDTTGPMTRDELKDLACLGFSSDLVMQSFCHTAAYPKPVDVTTHH
                     TLPDFIMNRGGVSLRPGDGVIHSWLNRMLLPDTVGTGGDSHTRFPIGISFPAGSGLVAF
                     AAATGVMPLDMPESVLVRFKGKMQPGITLRDLVHAIPLYAIKQGLLTVEKKGKKNIFSG
                     RILEIEGLPDLKVEQAFELTDASAERSAAGCTIKLNKEPIVEYLTSNIVLLKWMIAEGY
                     GDRRTLERRVQGMEKWLADPQLLEGDADAEYAAVIDIDLADIKEPILCAPNDPDDARLL
                     SDVQGEKIDEVFIGSCMTNIGHFRAAGKLLDNHKGQLPTRLWVAPPTRMDAAQLTEEGY
                     YSVFGKSGARIEIPGCSLCMGNQARVADGATVVSTSTRNFPNRLGTGANVFLASAELAA
                     VAALIGKLPTPEEYQTYVAQVDKTAADTYRYLNFDQLGQYTEKADGVIFQTAV"
     CDS             5459..5821
                     /locus_tag="ctg25_135"
                     /transl_table=11
                     /translation="MDYEFLRDITGVVKVRMSMDHEAIGHWFNEEVKDNLALLDEVEQA
                     ARTVKGSERSWQRVGHEYTLWLDGEEVMIRANQLDFSGDEIEEGMSYYDEESLSLCGVE
                     DFLQVVNAYRKFVGQS"
     CDS             6003..6956
                     /locus_tag="ctg25_136"
                     /transl_table=11
                     /translation="MNIKKAIERVPGGMMVVPLVIGAIINTFAPQALEIGGFTTALFKN
                     GAAPLIGAFLLCMGAGISVKAAPQALLQGGTITLTKLLIAIAIGLGVEQLFGAEGIFGL
                     SGVAIIAAMSNSNGGLYAALVGEFGNERDVGAISILSLNDGPFFTMIALGAAGMANIPI
                     MALVAVLVPLVVGMILGNLDPNMRDFLTKGGPLLIPFFAFALGAGINLEMLLQGGLAGI
                     LLGVLTTFIGGFFNIRADRLVGGTGIAGAAASSTAGNAVATPLAIAQADPSLAEVAAAA
                     APLIAASVITTAILTPVLTSWVAKKQARQVAEEKKA"
     CDS             6953..8224
                     /locus_tag="ctg25_137"
                     /transl_table=11
                     /translation="MKMIVIADDFTGSNDTGVQLAKKGARTEVMLTPDQKPSRRADVLV
                     INTESRAMPATEAGKAVAQALAPWCDGDARPLVYKKIDSTFRGNVGAEVTAAMRAANRK
                     LAAIAAAIPAAGRTTRDGLCLVNGTPLLETEFASDPKTPIISSRIATLIALQSDIPVHE
                     VSLEDVRRGQLSALLTAFSDEGECMVVVDAVEDRDLLLIAQAICEQTEMPLLVGAAGLA
                     NALPVSTFMQEKQELPVLVVAGSMSEATRRQVEKALCQARASVVDIDASRLASAQYEQE
                     MAAAVEQACALLSRQQHTILRTSRSADDRQMIDGLCAQAGVSRQQLGETLSERLGMITL
                     RIIEQARIGGLFLTGGDIATAVAAALGAEGYRIQSEVAPCIPCGTFVNSEIDDLPVITK
                     AGGFGSDSTLCDALYFIEEMYSGN"
     CDS             8214..9197
                     /locus_tag="ctg25_138"
                     /transl_table=11
                     /translation="VVTKTIAITMGDPAGIGPEIIVKALCEDELNGAPLVVVGCLKTLK
                     RLQDKGLAEGVTFRAIAEVAEARFVPGVIHVIDEPLAQPDALEPGKVQAQAGDLAYRCV
                     KRATALAMKGDVHAIATAPLNKEALHLAGHNYPGHTELLATLTESRDYAMVLYTDKLKV
                     IHVSTHIALRKFLDTLNGHRVETVIGIADRFLKRVGFTQPRIAVAGVNPHAGENGLFGD
                     EEIRIVSPAIENMKAKGIDVYGPCPPDTVFLQAYEGQYDMVVAMYHDQGHIPLKLLGFY
                     DGVNITAGLPFIRTSADHGTAFDIAWTGKAKSESMAVSIKLAMQLA"
     CDS             9207..9977
                     /locus_tag="ctg25_139"
                     /transl_table=11
                     /translation="MKGQHRLDKIVAYLKNHTLVTVEQLVDAVEASPATIRRDLIKLDE
                     QGVISRSHGGVALRRFEPSQPTTNEKQLRSPAEKQAIARFAASMVQAGDAVVLDAGTTM
                     LELAKCLTHLPLRVITVDLHIALFLSEFRQIEVTIVGGRIDDSSQSCIGEFGRKMLRSV
                     YPDIAFMSCNSWSVEKGVTTPTEEKAGLKQEIIANAQRKILLADSSKYGAHSLFNVAPL
                     SRFTDIITDVSLPLPVQAELKAQSVALTLVQPER"
     CDS             complement(10001..10795)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: AdoMet_dc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_140"
                     /sec_met_domain="AdoMet_dc (E-value: 2e-32, bitscore:
                     104.8, seeds: 266, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LKKLKLHGFNNLTKSLSFCIYDICYAKTAEERDGYIAYIDELYNA
                     NRLTEILSETCSIIGANILNIARQDYEPQGASVTILVSEEPVDPQLIDQTEHPGPLPET
                     VVAHLDKSHICVHTYPESHPEGGLCTFRADIEVSTCGVISPLKALNYLIHQLESDIVTI
                     DYRVRGFTRDVNGMKHFIDHEINSIQNFMSEDIKSLYDMVDVNVYQENIFHTKMLLKEF
                     DLKHYMFHTKPEDLSEEERKVITDLLWKEMREIYYGRNIPSV"
     CDS             complement(10810..11673)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_141"
                     /sec_met_domain="Spermine_synth (E-value: 9.6e-69,
                     bitscore: 223.7, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 1.8e-22,
                     bitscore: 72.2, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VADSNLWHETLHDHFGQYFSVDNVLYHEKTDHQDLIIFENAAFGR
                     VMALDGVVQTTERDEFIYHEMMTHVPLMAHGQAKHVLIIGGGDGAMLREVSRHRSVETI
                     TMVEIDAGVVSFCRQYLPNHNAGAYDDPRFTLVIDDGVNFVNQTAQTFDVIISDCTDPI
                     GPGESLFTSAFYEGCKRCLNPGGIFVAQNGVSFLQQDEAVDSHRKLSHYFSDVSFYQAA
                     IPTYYGGIMTFAWATDNEALRHLSSEIIQARFHKSNLKCRYYNPAIHAAAFALPQYLLD
                     ALSTVK"
     CDS             complement(11839..13593)
                     /locus_tag="ctg25_142"
                     /transl_table=11
                     /translation="MNGKIAKNFNPVSLAAVIVLALSPDAYAEKDALISVTASSNSDAS
                     GPAFLNYAKEHQAQKISEPVKPVEEKSNNTKTTNKKTVLNTHEVSRQAAIIAQKDKLIR
                     QLQQQLDAKPATMNAEAGNQKELKNKIQLLEKKLATAVAEKQQLIDNALSAAAEIKQIE
                     GQRNATENKTLQQEKRVALLESAKQKVERQLAEATAEKQSLQQKLATLETEKQDKLAAA
                     AAEKLALTGKFTTEAKERQALATRLAAAEAAQQEMLTKLTAADAAQRALQTKLDASQTE
                     QKAAIAKLAASEAEKTDLTTKLAAAGVEKQALTAKLDAVIISTPQPSLQADAGRQQAGQ
                     DNALQQASTDEITRLKSRLADAEARKPLAIDFAKEPLRQAYAIGVSMGEEVLQLLSTRA
                     SQGVKTSKDTVLQGIMDSFSGDIALDEKARNKALFDVSKKVFQNLKKLEQQTLSEGKKY
                     QQNFAKQKGVVLKDGIYSRIDYAGKGKILDSDIVTVTIKETLTDGTVINDMEAEGKVWS
                     QPLKSYPPLFLGPLKRLGNHGAITVVIPPNLAYGSEGKPPKIPPGATMVYTVRIVDATA
                     AEPQAKKP"
     CDS             complement(13590..13916)
                     /locus_tag="ctg25_143"
                     /transl_table=11
                     /translation="VKPLSESTLSQQQTEQQRIADEQARLDTCRKALESLKEVNPKQAD
                     KLGNEFTALLSAASQYNSVRSKVAEPTKQGIDSMYQFKSIKLCADIEKELIDSLVKRGE
                     NVQP"
     CDS             complement(14353..14712)
                     /locus_tag="ctg25_144"
                     /transl_table=11
                     /translation="MVEKMKTLFRTIVLGSLLTLSANSYALSESEAEDMADLTAVFVFL
                     KNDCGYQNLPNTQIRRALVFFAQQNQWDLSNYDSFNMKALGEDSYRDLSGIQIPTTKKC
                     KALARDSLSLLAYVK"
     CDS             14847..15896
                     /locus_tag="ctg25_145"
                     /transl_table=11
                     /translation="MQRREFLKLTAAVSVASALPLWSRSVFAASRPSLPVPELLTADAR
                     NRISLIIQAGKTQFGPHLATTWGYNGNLLGPALQLKQGEEATIDIHNRLAEETTVHWHG
                     LEVPGAVDGGPQGVIAAGGSRTVTFTPTQRAATCWFHPHQHGKTGRQVAMGLAGLVLIS
                     DAESEKLLLPKQWGIDDVPVIVQDKKFTSAGEIDYQLDIMSAAVGWFGDTLLTNGALYP
                     EHAAPRGWLRLRLLNGCNARSLNFATSDKRPMYVVASDGGLLAEPVKVNTLSVLMGERF
                     EVLVDTTDGKPFDLITLPVNQMGMAIAPFDRPQPVLRVQPLTIQASGKLPDVLAAMPAL
                     PSLQGGFVE"
ORIGIN
        1 catcccctaa attagcctga taaacctcat cattttggtt gaccataaag ctcatgatgc
       61 cggtttttcc ccattccaca ggccatgcca gcagggcgaa gccctgaccc tcgccatctt
      121 gaatgatgcg aaaacggtag ccgtgatagc cttcgccggg ttcggcgggg ctaaacgcgg
      181 gccctagcgg gctgggcgct tcgccgggag cggcaggcca gtagaggccg tctttcttac
      241 catcgctgct gataatcctc tgcgcccagg tgtggtttag ctgataaaaa tcctgctggg
      301 catcaacgta agcgtgcatc gcctgaatgg ctgacagctc attgcggcca atcgcgcgag
      361 tcaggatctc atcttcagca gcggccatat caaaacgcca gccgctctga tccttaatga
      421 tggggatcgg tagccgccat gcttcctgtc ccacctccag ccaggcgcta ttctgttgct
      481 gaacgatacg atggctgact ttccagtcgc gctgaaagcg agcgacggca tcagggtcga
      541 tgccctccgg cggtaaaaat tgctgccagc tatcgccgag cagcccgttg agggcagatt
      601 catcatgcct gccgatcgcc gcagccagcg cgcttgcggc ctgttccgga gaggaaaact
      661 gctgctgagc cagcgctatg gcgggcgtca gggccagcgc cagcagcgtc atttttaata
      721 attttttcat ctgattatcc tcagcggcgg cgcagttcac ggtgttcgga aagatgttct
      781 ctggccgcgc tgcgctgctc gctgcttaaa cccgagatat gacggctctg caggccgcgc
      841 tcctgctgag actgccagga gggagagcgg atatcgttac cgctcagggc attggcgtgc
      901 aggttattca gcttctgctg acgttgttcg ggcgttgcgg cccggaactg ttcacggcgc
      961 tgttgctgct gcgtcgtcgg atgctgaatc gttttggccg cttcccgatg ctgctgttgt
     1021 acggcgctat tttttaccgc cggcgtggcg tcatagccgc gatagttatt gcgctgggtc
     1081 acctgatgga gctgctgcga cgcggcctgg cgctgggcat cgcgggaagg cgcgtgatta
     1141 agcgcgttgt ccgcaggccc ggtacgctgc tgtagctgcg tcatggccgc ctgacgctgc
     1201 gcgttgcgat cggcgggctg atgttgggtc gcgctaagcc cgccgggaac attggtctga
     1261 tggtaatgct gcgcaatcgt gttgtccgga tagggaatat tgccgcggta ggccggatta
     1321 tgctgccagc tggcgcggtt tcccggcagg ttctgcccgg taatatggtt gaaattattg
     1381 acgttgatgt tgatgttatc gccgttgtgc gtgtagccac cgtgatgatc atcatcgtga
     1441 tggtgatcgt catcgtcatg gtggtgatga tcgtcatcat cccagtcgat gctgctgaac
     1501 agagcgtagg ttgtggcgac gccgaggcta tagccaaacc ccttgacgaa gctgtcggta
     1561 aactgctccc ccggaggcgg gggcaggtag accggcggat aggcggtgtc aggccaggcg
     1621 ccgtaaacta ctgaagggtt ataggccggc acgtacacca catttggatt ggtggattcg
     1681 attttaatca cctgcgccgg ggcggaggat gtcacggcgc tgctgctgcg ggaagcggtg
     1741 gccgtcgacg ttgccggagc tggagccgcg gagcgggtgg cggtgatgac tttctgctgc
     1801 ggcgtggatt ttaacgttcc ggtctgctgg gcgatggcgc gtaagcgctg caccgaatcc
     1861 atgacggcct gcggctgggc gagaaatgcg ttccccaggt tttccaccca cggcgcattt
     1921 tctcccatta acgcgagcag ggaagggaag gcgaccagcg attttacgct ggggtcccag
     1981 ggctgatttg ccaccgcttg caccgccgca tcgcccttca ttgtggggtt atcctgcgac
     2041 cactctaccg cctggacaac gttactcggg taggtcgaag ccatcagcac ctgcgacagc
     2101 agattgtccg gatagagcgc gattggcgcg acccactggt ctatctgcgc agatgtatag
     2161 gtcgtggcca ccggctgggc ggcggcggtt gcctgcgccg tctgcgcaac ggcggggggc
     2221 tcgggaaccg tttgcggctc ccgactttta acgtagagcg tacccgcggc ggctaatagc
     2281 ccggcgctac agagtagcgc gagcagatgg ggtttgaaag gcagtgtcat gagaactccc
     2341 ggcacaataa ttggcccgtt ttgacagagt attgtcgaaa agcgggggat tgcctgagta
     2401 tagagagcgc gtatttgcgt ttttgatttt agttgggatt tcgctcaatt atgtgtaaca
     2461 gaattaattt tatataccgc taaattgaca gaaaacctgc attattctgc ccttaacgat
     2521 tcagctaatt tttaatgttg cttttttgta aacagattaa caccccgcca aaatcctgct
     2581 atgctgccga cgcggtatcg ggcatttacc ctacaaactg ctgtctcaca ggagcgtgaa
     2641 gagaatcgcc taccgcattt tacaatgaga gcgaggagaa ccgtcgtgct agaagaatac
     2701 cgtaagcacg tagctgagcg tgccgccgag gggattgtac cgaaaccctt agatgcaacc
     2761 caaatggccg cgctggtaga actgctgaaa aacccgccag cgggtgaaga agaattcttg
     2821 ttagacctgt taattaaccg cgtaccgccg ggcgtcgacg aagccgccta tgttaaagcc
     2881 ggattccttg ccgcgatcgc caaaggcgaa gcaacttctc cactggttac ccgtgaaaaa
     2941 gctgtcgaac tgctgggcac catgcagggc ggttacaaca ttcatcccct gattgacgcg
     3001 ctggacgacg caaaactggc gccgatcgcc gcgaaagcgc tgtcccacac cctgctgatg
     3061 tttgacaatt tctacgatgt agaagagaaa gccaaggcag gcaatgccta cgccaaacag
     3121 gttatgcaat cctgggctga cgctgagtgg ttcctgagcc gtcctcagct ggctgataaa
     3181 atcaccgtga ccgtttttaa agtcaccggc gaaaccaaca ccgatgacct gtctccggcc
     3241 cctgacgcct ggtcccgccc ggatattccg ctgcacgcgc tggcaatgct gaaaaacgcc
     3301 cgcgaaggca ttgacccgga tcagcccggc gccgttggcc cgattaaaca aattgaagca
     3361 ctgcagcaaa aaggtttccc gctggcgtac gtcggcgatg tcgtgggtac cggctcatcg
     3421 cgtaaatccg ccaccaactc ggtgctgtgg tttatgggcg acgatattcc gcacgtgccg
     3481 aacaagcgcg gcggcggtct ggttctcggc ggcaaaattg cgcctatctt ctttaatacc
     3541 atggaagatg ccggcgcgct gccgattgaa gtggacgtaa acaacctgaa catgggcgac
     3601 gtgatcgacg tttatccgtt caaaggtgaa gtccgtaacc acgaaaccgg cgaactgctg
     3661 gcgaccttcg agctgaaaac cgacgtgctg atcgacgaag tgcgcgccgg cggccgtatc
     3721 ccgctaatca tcggtcgtgg cctgaccacc aaagcgcgtg aagcgctggg cctgccgcac
     3781 agcgatgtgt tccgtcaggc gaaagacgtg gcggaaagca gccgcggata ctctctggcg
     3841 cagaaaatgg tgggtcgcgc ctgcggcgtg gccggggttc gtccgggcgc ttactgcgaa
     3901 ccgaagatga cctccgtagg ctctcaggac accaccggcc cgatgacccg tgatgagctg
     3961 aaagacctgg cgtgcctggg cttctcttcc gacctcgtga tgcagtcctt ctgccatacc
     4021 gccgcctatc cgaagccggt ggacgtcacc acgcaccaca cgctgccgga cttcatcatg
     4081 aaccgcggcg gcgtatcgct gcgtccgggc gatggcgtta tccactcctg gctaaaccgt
     4141 atgctgctgc ctgataccgt gggtaccggc ggtgattcgc atacccgttt cccgatcggt
     4201 atctccttcc cggcaggctc aggcctggtg gcgtttgccg ccgcaactgg cgtcatgccg
     4261 ctggatatgc cggaatcggt tctggtacgt tttaaaggca aaatgcagcc gggcatcacc
     4321 ctgcgcgatc tggtacacgc catcccgctg tatgcgatca aacagggtct gctgaccgtg
     4381 gagaagaaag gtaagaaaaa catcttctcc ggccgcattc tggaaattga aggtctgccg
     4441 gatctgaaag ttgagcaggc gtttgagctg accgatgcct ccgccgagcg ttccgcggcg
     4501 ggctgtacca ttaagctgaa caaagagccg atcgttgagt atctgacctc caacatcgtc
     4561 ctgctgaagt ggatgatcgc cgaaggttac ggcgatcgcc gtacgctgga gcgtcgcgtt
     4621 cagggcatgg aaaaatggct ggcggatccg caactgctgg aaggcgacgc ggatgcggaa
     4681 tatgcggcgg tgatcgatat cgatctggcc gatatcaaag agcccatcct ctgcgcgccg
     4741 aacgatccgg acgatgcgcg tctgctgtcc gacgtgcagg gcgagaagat cgatgaagtg
     4801 tttatcggtt cctgcatgac caacatcggc cacttccgcg cggccggtaa gctgctggac
     4861 aaccacaaag gccagctgcc gactcgtctg tgggtggcgc cgccaacccg tatggacgcc
     4921 gcgcagctga ctgaagaggg ctactacagc gtgtttggta agagcggtgc gcgtattgaa
     4981 atccctggct gttctctgtg catgggtaac caggcgcgcg ttgccgacgg tgcgacggtg
     5041 gtctctacct caacccgtaa cttcccgaac cgtttaggta ccggtgctaa cgtcttcctg
     5101 gcctctgcgg agctggcggc cgtggccgcg cttatcggta aactgccgac gccggaagag
     5161 tatcagacct atgttgctca ggtggataaa accgcagcgg atacctatcg ttatctgaac
     5221 ttcgaccagt tgggtcagta caccgagaag gccgacggag ttattttcca gaccgcggtg
     5281 taatgcgata acttagcgct gtacataatc ccgccaatgc ccggtgaact ttgcgtcacc
     5341 gggcattttt atttcccgtc cctccgccca ccacgctttt tttctctccc actgctgcga
     5401 taataactgt atgggtacag tgcagcggtg acgcactgcc cttgcagagg aaaagactat
     5461 ggattacgaa tttctgcgcg atattaccgg agtggtaaag gtgcgaatgt cgatggatca
     5521 tgaggcgatc ggccactggt tcaacgaaga ggttaaagat aaccttgccc tgctggacga
     5581 agtcgagcag gccgcgcgca ccgttaaagg cagtgaacgt tcctggcaac gtgtcggcca
     5641 tgaatacacg ctatggctgg acggcgaaga agtgatgatc cgcgctaacc aactggattt
     5701 ttccggcgat gagatagaag aggggatgag ctactatgac gaagaaagcc tctcgctatg
     5761 cggtgtggaa gactttcttc aggtcgtcaa cgcctatcga aaatttgtag gtcaatcctg
     5821 agcaacgtta atcatttcca cggccggaca gctatgtccg gctttttttt agccttaacg
     5881 gcctggtttg atttttatta atcattttaa aactgtgatc tggcgcgttt gtgaagttta
     5941 tttgattgaa tataatcttt atgattttat ttaatcacag cataacaaca ggcgggaaga
     6001 ccatgaacat caaaaaggct atagaacgtg tacctggcgg catgatggtt gtgccactgg
     6061 tgatcggcgc cattatcaat acctttgccc cgcaagcgct tgagatcggc gggttcacca
     6121 ccgcgctgtt taaaaacggc gcagcaccgc tgattggcgc cttcctgctc tgcatggggg
     6181 cgggaattag cgtcaaggca gcgccacagg cgctgttgca gggcggtacc attacgctga
     6241 ccaaactcct gatcgccatt gcgattggcc tcggcgtgga acagctcttt ggtgctgaag
     6301 ggatcttcgg cttaagcggc gtggcgatca tcgctgcgat gagtaactcg aatggcgggc
     6361 tttacgccgc gctggttggc gagtttggta acgagcgtga tgtgggagcg atctccatcc
     6421 tgtcactgaa tgacgggcca ttctttacga tgatcgcgct gggcgcggcg gggatggcca
     6481 acattcccat catggcgctg gtcgccgtgc tggtgccgct ggtggtggga atgatcctgg
     6541 gtaacctcga tcccaacatg cgcgacttcc tgaccaaagg cggcccgctg ttgatcccat
     6601 tcttcgcttt tgcgctgggc gcagggatca accttgaaat gctgctacag ggcggtctgg
     6661 cgggcattct gctcggcgtg ctgacgacct tcatcggcgg tttctttaac attcgtgccg
     6721 accgtctggt aggcggaacc gggattgccg gcgcggcggc gtccagcacc gccggaaacg
     6781 ccgtggcgac gccgctggcg attgcccagg ccgatccctc tctggcagag gttgccgccg
     6841 cggccgcgcc gctgattgcc gcatcggtga tcaccaccgc gattctgacg ccggtcctca
     6901 cctcatgggt ggctaagaag caagcgcgtc aggttgcaga ggagaaaaaa gcatgaaaat
     6961 gatcgttatc gccgacgact ttacgggttc taacgatacc ggcgtgcagc tggcaaagaa
     7021 gggggcgcgc acggaagtga tgctaacgcc ggatcaaaaa ccttcgcgtc gcgctgatgt
     7081 gctggtgatc aacaccgaaa gccgcgcgat gcctgcaact gaggccggga aagcggtagc
     7141 gcaggcgtta gcgccgtggt gcgatggtga tgcgcgtccg ctggtttaca agaaaatcga
     7201 ctccactttc cgcggcaacg tgggggctga agtgacggcg gcaatgcgtg ctgcaaaccg
     7261 gaagctggcc gcgattgcgg cggctattcc cgcagccggg cgcaccactc gcgacggatt
     7321 atgcctggtc aacggtacgc cactgctgga aaccgaattc gccagcgatc cgaaaacgcc
     7381 cattatctcc tcgcgaattg cgacgttgat cgccctgcaa agcgacatcc cggttcatga
     7441 agtgtcgctc gaagacgttc gtcgggggca attgagcgcc ctgttgacgg ctttttcaga
     7501 cgagggtgag tgcatggtgg tggtggatgc cgtggaagat cgcgatctgt tgctgattgc
     7561 ccaggctatt tgtgaacaaa cagagatgcc gctgttggtg ggcgctgccg ggctggcgaa
     7621 cgcgctaccg gtcagcacct tcatgcagga aaagcaggag ctaccggtac tggtggtggc
     7681 cggatcgatg agcgaggcca cgcggcggca ggttgaaaaa gcgctctgcc aggcgcgcgc
     7741 cagcgtcgtg gatattgacg cctcgcggct ggcatcggcg cagtacgagc aggaaatggc
     7801 cgcggcggtt gaacaggcct gtgcgctgct cagtcgccag cagcacacca ttttacgtac
     7861 cagccggagt gcggacgatc ggcagatgat cgacggcctg tgcgctcagg ctggcgtaag
     7921 ccgccagcag ctcggtgaga cgcttagcga acgcctcggg atgattacgt tgcgcattat
     7981 cgaacaggca cgtattggcg ggctgttcct gaccggagga gatatcgcca ccgcggttgc
     8041 cgccgcgctc ggggcggaag gctatcgcat tcagagtgag gtggcgccct gtattccctg
     8101 cgggacgttc gttaacagtg aaatcgacga tctgccggtt atcactaaag ccggcggatt
     8161 tggttcagac agcacccttt gtgatgcgct ttattttatt gaggagatgt acagtggtaa
     8221 ctaaaacaat tgcgattacg atgggcgacc cggcgggcat cggtccggaa attattgtca
     8281 aagcgctttg tgaagacgag ctcaacggcg cgccgctggt ggtggtcggg tgtctgaaaa
     8341 ccctgaaacg tctgcaggac aaagggctgg cggaaggtgt cacctttcgc gcgatcgccg
     8401 aggtcgcgga ggcgcgattt gttcctggcg tgattcatgt catcgacgag ccgctggccc
     8461 agccggacgc gctggagccg ggtaaagtgc aggcccaggc gggcgatctg gcctaccgct
     8521 gcgtgaagcg ggcgacggcg ctggcgatga aaggcgacgt acatgccatc gcgaccgcac
     8581 cgctgaataa agaagcgctt catctggccg ggcacaatta tcctggtcat accgagctgc
     8641 tggcgacgct gactgaaagc cgcgattacg ccatggtgct ctacaccgac aagctgaagg
     8701 tcattcatgt ctcgacccac attgcgttgc gtaagttcct cgatacgctt aatggccatc
     8761 gcgtggagac agtcatcggc atcgcggatc gcttcctgaa acgcgtcggc ttcacccagc
     8821 cgcgtattgc cgttgccggg gtcaatcccc atgcgggcga aaacggtctg tttggcgatg
     8881 aagaaatacg cattgtgtcg ccggccattg aaaacatgaa agcgaagggt atcgatgttt
     8941 acgggccctg cccgccggac accgtgtttc tacaggcgta cgaggggcaa tatgacatgg
     9001 tggtggcgat gtaccacgat cagggacata ttccgctcaa actgcttggc ttctacgatg
     9061 gggtgaatat caccgcgggt ctgccgttca tccgtacctc agccgatcac ggcaccgcgt
     9121 ttgatatagc ctggacggga aaagcaaaat ctgagagcat ggccgtatcg attaaactgg
     9181 caatgcaact ggcgtaattt cctgttatga aaggacaaca ccgtctggat aagattgtgg
     9241 cgtatttgaa aaatcatacg ctggtgaccg tggaacagct ggtggatgcg gtagaagcat
     9301 cgcctgcaac gatacgacgc gatctgatca aactggatga gcagggcgtg atcagccgca
     9361 gccacggcgg tgttgctctg cggcgctttg agccttctca gcctaccacc aatgaaaagc
     9421 agctacgatc gcctgcggaa aagcaggcga ttgcgcgttt tgccgcctcg atggtgcagg
     9481 cgggcgacgc ggtggtactg gacgccggca ccaccatgct ggagctggca aaatgcctga
     9541 cccatcttcc gctcagggtg atcacagtcg atctgcatat cgctctgttt ttatccgaat
     9601 tccgccagat agaagtgacc atcgtcggtg gccgcattga tgacagcagt cagtcctgta
     9661 tcggcgagtt tggtcgtaag atgttacgta gcgtctatcc cgatatcgct tttatgagct
     9721 gtaacagctg gagcgtggaa aagggcgtga cgacgccgac ggaagaaaag gcggggctaa
     9781 agcaggagat cattgccaac gcccagcgta agatcttact ggccgacagc agcaaatatg
     9841 gcgcccactc gttgttcaac gtcgctccgc tgagccgctt cactgacatt attaccgatg
     9901 tgagtttgcc tcttcccgtt caggctgagc tgaaagcgca gtccgttgcc cttacgctgg
     9961 tacagcctga acgttaagga taccgctagc cgatacggtg ttacacgctc gggatattac
    10021 gtccgtagta gatttcgcgc atctctttcc agagcaggtc ggtaatcacc ttacgctcct
    10081 cttcgctcaa atcttccggc ttcgtgtgga acatatagtg cttaaggtcg aactccttaa
    10141 gcaacatctt ggtatggaaa atattttcct gataaacgtt cacgtccacc atgtcataca
    10201 aagacttaat atcttcggac atgaagttct gaatggagtt aatttcatga tcgatgaagt
    10261 gcttcatgcc gttcacatcg cgggtaaaac cgcgaacgcg ataatcaatc gtgacgatat
    10321 cggattctag ctggtgaatc agatagttca gggccttcag cggtgaaatg accccgcagg
    10381 ttgagacttc aatatcggcg cggaaggtgc acagtccgcc ctcaggatgg ctttccggat
    10441 aggtgtgaac gcagatatgg cttttatcga gatgtgccac cacggtctcc ggtagcggac
    10501 ccgggtgttc tgtctgatcg ataagctgcg gatcgacagg ctcttcgctg accaggatcg
    10561 tcacgctggc gccctgtggt tcataatcct ggcgggcaat gttaagaata ttggcgccga
    10621 taatcgaaca ggtctctgac aaaatttccg tcaggcggtt ggcgttgtag agttcgtcaa
    10681 tataggcgat gtagccatcg cgctcctctg ccgtttttgc gtagcagata tcgtaaatgc
    10741 aaaaactcag gcttttggtc agattgttaa agccgtgcag cttcaatttt ttcaatttag
    10801 atcacctcct tacttaacgg tggatagcgc atccagtaaa tactgcggta aagcaaatgc
    10861 cgccgcgtga atggccggat tgtaataacg gcacttcagg ttcgacttgt gaaaacgggc
    10921 ctggatgatt tcactggaaa gatggcgcag cgcttcgttg tccgtggccc atgcgaaggt
    10981 cataatgccg ccgtagtagg tgggaatcgc cgcctgatag aagcttacgt cgctaaagta
    11041 atggctgagc ttgcgatggc tatcgacggc ctcatcctgt tgcaggaagc tgacgccgtt
    11101 ctgagcgacg aagatcccgc ctgggttgag gcagcgcttg cagccttcat agaaggcgga
    11161 agtaaacagg ctctcgccgg gaccgatagg atcggtgcag tcggagataa tgacgtcaaa
    11221 cgtttgcgcc gtctggttaa caaaattgac gccatcgtca atcaccaggg taaagcgcgg
    11281 gtcgtcgtac gcacccgcat tatggttggg gaggtactgg cgacagaatg aaaccacgcc
    11341 agcgtcaatt tctaccatgg tgatggtttc gacgctgcgg tgacgggaga cttcgcgcag
    11401 catggcgcca tcgccgccgc cgataattaa cacatgtttc gcctggccgt gggccatcag
    11461 aggaacatgg gtcatcattt catggtagat aaactcatca cgttcggtgg tttgtaccac
    11521 gccgtccagc gccatcacgc ggccaaaggc tgcgttttcg aaaatgatta aatcctgatg
    11581 atcggttttc tcatgataca gaacgttatc aacgctgaaa tactgaccaa aatggtcgtg
    11641 cagcgtttca tgccacagat tgctatcggc cacgggcaga tcctcctttg ttaacacctg
    11701 ttacacccat caaaaatgag cgcaacatca tagccaacta tagaagatga tgcacggtgg
    11761 atatttcagc aaatgaagcg tggagcatta cccgttcaaa aagaggggaa agcgcctccc
    11821 cgatgggagg cgccaggatc agggtttttt agcctgtggt tctgccgcag tggcgtcaac
    11881 gattctgacg gtatatacca tggtcgctcc cggcggaatt ttaggcggtt tgccttcgct
    11941 gccgtaggcg agattgggag ggatcacgac cgttatcgct ccgtggtttc ccagccgctt
    12001 gagtggccca aggaagaggg gaggataaga tttcagaggc tgggaccaga ctttcccctc
    12061 cgcttccata tcgttaatga cggttccgtc ggtaagcgtt tccttgatag tgacggtaac
    12121 gatatcgctg tcgagaatct tgcccttgcc ggcataatct atgcgactgt aaatgccgtc
    12181 tttcaatacc accccttttt gcttcgcgaa attttgttga tatttctttc cttcgctaag
    12241 ggtttgctgt tcgagcttct ttaggttctg aaagactttt ttagacacat cgaataaggc
    12301 tttattgcgc gctttctcat caagggcgat atcccctgaa aaagaatcca taatcccctg
    12361 taatacggta tctttactgg tttttacgcc ctgagatgcc cgggtagata agagctgtag
    12421 cacttcctcg cccatcgata caccgatagc gtaagcctgc cgcagaggct cttttgcaaa
    12481 gtcgatagcc agcggctttc tcgcctcggc gtcagcaagc ctggacttta gccgggtaat
    12541 ttcatcggtg ctggcctgct gtagggcgtt gtcctgaccg gcctgctgac ggcctgcatc
    12601 cgcctgaagg gacggctgcg gcgtactgat gataacggcg tccagtttag ccgtgagcgc
    12661 ctgtttttct actcccgcgg ccgccagctt tgtcgttaaa tctgtttttt ccgcttcact
    12721 ggcggcgagc ttcgctatcg ctgctttctg ctcggtttga gacgcatcta gtttcgtttg
    12781 cagcgcccgc tgtgcggcgt cagccgcggt gagttttgtt agcatttcct gctgagctgc
    12841 ctccgcagca gcgagcctgg ttgcgagggc ttgcctctct ttcgcctctg tcgtgaactt
    12901 accggtgagc gcgagtttct ccgctgcggc cgccgccagc ttatcctgct tttctgtttc
    12961 cagcgtcgcg agcttctgct gcagggattg cttttccgcg gttgcctcag ccagctgacg
    13021 ctcaactttt tgtttcgcgg attctagtaa tgccactctt ttttcctgct gcagcgtttt
    13081 attttctgtg gcattacgct ggccctcgat ctgttttatt tcagccgcgg cggatagcgc
    13141 gttatctatt aattgttgtt tttcggctac ggcagtcgct aactttttct caagcagctg
    13201 aattttattc ttcagctctt tttggttgcc tgcttcggcg ttcatcgtgg ccggcttcgc
    13261 atcaagctgc tgctgaagtt ggcggatgag tttatctttt tgagcaatga ttgcagcctg
    13321 acgggaaact tcatgggtat tcaggacggt ttttttattc gttgtttttg tattattgct
    13381 tttctcctca acgggcttta ccggctcgct gattttttgc gcctgatgct ctttagcata
    13441 atttaaaaat gccgggcctg aagcatcgct atttgagctc gccgtgacgc tgataagggc
    13501 atctttttcc gcataggcat ccggcgatag cgccagcaca ataactgctg ccagcgatac
    13561 cggattgaag tttttggcta ttttcccgtt catggctgaa cattttcacc acgtttaaca
    13621 aggctatcga tcagctcctt ttcaatatca gcgcacagct tgattgattt gaactggtac
    13681 atcgaatcga tcccctgttt tgtcggttct gctactttac tgcgcacgga attatattgt
    13741 gatgccgcgc taagcagggc agtgaactca ttgccgagtt tgtccgcctg tttggggttc
    13801 acttctttca gcgactccag cgctttacgg caagtgtcta aacgcgcttg ctcatcggcg
    13861 attctctgtt gttcggtttg ctgttggctt aatgtcgact cagataaggg tttcactgat
    13921 ccggcggatt gcctgggttg tattgaatta caacccgcta ataaaatgag ggccagaggg
    13981 gctatgcttg taaataagga tctgttcaag gtttcattcc attgataaaa agaggtgtta
    14041 tcgggcgata atagtgtgcg aaaaagaaga atgcaataat agagtttatg atttttgatg
    14101 gcgtactttt aatactagtt atacccgcca tatttcaagc tgctgatgtg ttggctacgc
    14161 tcgcttaccc cttgccgcct acaagtaact ctcattattt agggtatata ttaatatgtt
    14221 gaatgcttaa tgaattatca ttgaattcta tgaattgaga tataaattaa gtgctgttgt
    14281 taattgaatt gctattatta cgcggcgtca tagccgtatt cgtacggcta ccgttttctg
    14341 aaatgaaggg ggttatttca cgtaagcgag caggctaagc gaatcgcggg ccagcgcttt
    14401 gcatttttta gtcgtgggta tctggattcc gctaaggtcc cggtagctat cttcgccgag
    14461 cgctttcata ttgaagctgt cgtaattgct taaatcccat tgattctgct gagcaaaaaa
    14521 gaccagggca cggcgaatct gcgtgttagg cagattttga taaccgcagt cgttcttcag
    14581 aaagacgaat actgccgtta aatcagccat atcttccgct tcggactcgc ttaatgcata
    14641 gctattggcg gagagagtca gcaggctgcc aagcactatt gttctgaaaa gcgtcttcat
    14701 tttttctacc attgaatcac ggacaaacaa agttagcaca cttcgttaca gtgcgctgag
    14761 ctttattctt actcttctgc ttgaccttcc tgttggggga gggtttaagc tcaattattc
    14821 accagcagaa taaaaaggat gtgaaaatgc aacgtcgtga gtttcttaaa ctaaccgctg
    14881 cggtcagcgt ggccagcgca ttgccgctat ggagccgctc ggtttttgcc gccagccgcc
    14941 catctttgcc tgtacccgaa ctgcttaccg ccgacgcgcg taatcgcatc tcgttaatca
    15001 ttcaggctgg aaaaacgcag ttcggccctc atctggcgac cacctggggc tataacggca
    15061 atctgctggg cccggcccta cagcttaagc agggtgagga ggcgaccatc gatattcata
    15121 accgtctggc ggaagagacc accgtgcact ggcacggtct ggaggttccc ggcgccgtgg
    15181 acggcggtcc ccagggcgtg attgccgccg gaggctcccg cacggtgacc tttaccccaa
    15241 cgcagcgggc ggcgacctgc tggttccatc cccatcaaca tggcaaaacc ggcagacagg
    15301 tcgcgatggg gctggcaggg ctggtgctga tttctgatgc agaaagcgaa aagctgctcc
    15361 tgccaaagca gtggggaatt gatgatgtcc cggtgattgt gcaggataaa aaattcacct
    15421 cagcgggaga gattgattat cagctcgata ttatgagcgc agccgtgggc tggtttggcg
    15481 atacgctgct cactaacggc gcgctgtacc cggagcacgc tgcgcctcgc ggctggctac
    15541 gtttacgtct gctgaatggc tgtaatgcgc gttctttgaa tttcgccacc agcgataagc
    15601 ggcccatgta cgtcgtggca agcgatggtg gtcttctggc tgagccggtg aaagttaaca
    15661 cgctgtcggt gctgatgggc gagcgtttcg aggtgctggt ggataccact gacgggaagc
    15721 ccttcgattt aattacgctc ccggtcaacc agatggggat ggcgatcgct ccgtttgatc
    15781 ggccgcagcc agtgttacgc gtgcagccac tgactatcca ggcttccggt aagctgccgg
    15841 atgtgctggc cgctatgcca gcgctgccct cgcttcaggg cggctttgtt gaataaatcg
    15901 aacttttgct gagttgaagg atcagatcac gtatcttccc gacaacgcag accgttccgt
    15961 ggcaaagcaa aagttcaaa
//
