LOCUS       c00021_NZ_CALI..        8688 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CALIRK010000021.1 MAG: Slackia isoflavoniconvertens isolate
            SRR2846706_bin.202_CONCOCT_v1.1_MAG ERZ505731.13962, whole genome
            shotgun sequence.
ACCESSION   c00021_NZ_CALI..
VERSION     c00021_NZ_CALI..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 00:16:32
            Original ID  :: NZ_CALIRK010000021.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 8688
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..8688
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3293:8611]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3294..8611
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..8688
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..8688
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(285..1151)
                     /locus_tag="ctg21_1"
                     /transl_table=11
                     /translation="MQPSSTLQPIGTQQHVETHPGTTEAEEQSLPSIDLPPDADFYGDY
                     LQKLKEITWRFEISLETYLMERGINRERKPISSWKTRIKSPDSMREKLIKRGYEPTAEN
                     AVYAVHDAAGVRVICPLVDDVASVAQFIRELPCFEVVQEKDYILHPKPNGYRSYHMILA
                     RTNDSELDPDATRRAAAKAAIEAQEISLSQLIDQLNTSGTFDAVESKGAEAQTGDNHFE
                     FGRRMCVEVQLRTIAMDSWASIEHDLKYKKDVPNQEFLQAELKRCADEMAATDLSLQTI
                     ADLINVK"
     CDS             complement(1323..2747)
                     /locus_tag="ctg21_2"
                     /transl_table=11
                     /translation="MCEACSIESNQTPQDMAYTPGKPFPTHHAQNASDYLNAALSAERW
                     IATFEHRTPEGIFWQQDASQPIDLSLYSGSAGVAYFYLKLTEVTGNAEFAEKARCGLSY
                     AAAHWRDLLLPEQAAFQDNREGVPGVHLGAHMGVGGVGLVLIEGAKTFAESRDAEKYRR
                     AAQAIGRFYTDESVQQGESGPYWTGSPALLMDGGIMLFLIALYETFGDQQLLEFIKAAG
                     AQYLRWGAESPRGGVDFNGAGIETPFDWPNFAFGSAGSGYLLAHLFRITGDARYLEVAR
                     RCADFLDAVAVPQKRGKLIPHKLGGDDEFTVFYLGYCHGIAGTLRFPTLMGTLDNDIRW
                     ATMVNQLADGAEALGAPEHMSAGLWNTVCYCCGHAGMAHTFLGLYCIDGSPRWREFAIR
                     CGDILLGSMKTHADGSASWPFAWERVHPEELSQRIGFYDGAAGIASTLLELFMLERDDY
                     HWPRMIDDPFPEDPRR"
     CDS             3294..4970
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg21_3"
                     /sec_met_domain="ILVD_EDD (E-value: 1e-215, bitscore:
                     705.8, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLRSDAVKVGVARAPHRSLLKADGLTDEEMKKPLVAVFNSRNDI
                     IPGHNNLDKICEAVKAGIYMAGGVPFEISTIGVCDGIAMNHDGMHYSLVSREAIADSFE
                     CAVQGHQFDAAVCIPNCDKIVPGMVLGALRVNIPTVFVSGGPMLPGHEAGCNCGPTTDL
                     NTLFDGAGQVSAGTMTEEQLKYYEDTACPTCGSCSGMFTANSMNCLCEALGIALPGNGT
                     IPAVYSERLRLAKHAGMKVMELLEKGICIKDIISEAAIHNAMECDMAFGGSTNTVLHLT
                     AIAMAAGHPITMDDWDAASARTPHLVKLQPSGPRPLIDLYAVGGVPVVMHELNELGLLD
                     ESAITCMGPLPEYIANCTKPADGEVCRKHDNPFSKVGALRVLHGNIAPDGGIVKKSAVD
                     PSMLTHTGPARCFNSEEEACEAIFAGEIKPGDVVVIRYEGPKGGPGMREMLTPTSAIVG
                     MGLSKSVALLTDGRFSGASKGPCVGHVSPEAAAGGPIALIEDGDQVTVDIEGGKLELHV
                     SDEELAARRAAFVAPAPKHNHGVLAKYAKLVSSADKGAYVS"
     CDS             4967..6829
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg21_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 6.4e-52, bitscore:
                     164.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMNTLTDKLTQKQLAIEGKPLGPGSHTEHEGKTMTGAQAIIASLE
                     AEGVDTVFGYPGGQAIKIYDALYDSKKLHHVLARHEQGATHMADGYARATGKVGVVLVT
                     SGPGATNTVTGIATAYMDSIPMVVITGQVTRGVIGTDSFQESDIVGITMPIVKHSFLLQ
                     STDDLTETFREAFYIASTGRPGPVLIDIPSDLQGAEMVFHYPDSVNIPSYRPTYKGNAK
                     QIKQATALIETSKRPLLYAGGGIVSSHACQELKALAEAMQIPVVTTLLGKGCFPSSHPL
                     SLGPVGMHGSKYANMAMTECDLIIAAGARFSDRVTGKLDEFAPNAKVIHIDIDPAEIGK
                     IREANVPIVGDAQGILGGIVAQLEKSGATPVDAEWVETVNEWRERWPYYDDQFNDYPNQ
                     IVPEVALDELSKQLDPDNSIVTTEVGQHQMWAHQHIGREHARSFLSSGGLGTMGFGFPA
                     AIGAKFGCPDKQVVCVAGDGSFQMNSQEMATAAINNTAVKVFLLDNRALGMVHQWQKLF
                     YHERYSSTILDPVPDFVKLADSYGWEGERIEKPEDVAPAIARMLASEKPYLLDVAISPD
                     QNVYPMVAPGAALDNVIGAIDVTLGAVRVNGKGVGKKDEKEGEE"
     CDS             6829..7311
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg21_5"
                     /sec_met_domain="ALS_ss_C (E-value: 2.1e-32, bitscore:
                     100.0, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHILSVLVENKSGVLSRVTGMISRRGFNIESLTVAPTEDSTMSR
                     LTAIVNADEVGYEQITKQLHKLVSVYKITDLTDEDAIERELALFKVSAPPDRRHEIIEI
                     ANVFRANIVDVGKNSLTIEATGDESKLEAMEDLFRAYGLKQLVRTGKIAMSRNSKD"
     CDS             7607..8611
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg21_6"
                     /sec_met_domain="IlvN (E-value: 1.8e-79, bitscore: 253.8,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 7.7e-65, bitscore: 206.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVTIYYENDVNPEVIKGKKVAIIGYGSQGHAHALNLMDSGVDVR
                     VGLREGSKSWAKAEEAGLKVMLEDEAAEEADVIMILIPDELQPEVYEQHIAPHLHAGDT
                     LAFAHGFNIHYGYIKAPEDVNVIMCAPKGPGHIVRRQFTEGSGVPDLACVAQDATGDAW
                     DIAMSYCWGVGGARSGIIKATFAQETEEDLFGEQAVLCGGLVELVKAGFETLTEAGYPP
                     ELAYFECYHEMKMIVDLMYESGIHFMNYSISNTAEYGEYYAGPKVINEQSREAMKEILT
                     RIQNGEFAKEFVADCKNGHKWLFEQREAINNHEIEKTGAKIRDMFSWVKSDEE"
ORIGIN
        1 gcgacgaggg catcagggcg aggatagaga ggttcctgtg aaaagactta cacaggcttc
       61 ttgacaagcc cggtctagcg taaagcgagg cgcccgtttt tgccaaaagc tgcgaatccg
      121 ggggcttttc agcattggaa agcaagggag gttggcccta tttgcaagac atatcttgca
      181 aatagggcca acctctactc tgaaacggct ttatgggtcc tcgaagtgcg gcgattctgg
      241 caaatacgcc cccgaattcg caacttttgt cactttttgc cgatttactt tacgttgatc
      301 aagtcggcga tagtttgcaa cgacagatcg gtcgccgcca tctcgtcggc gcagcgtttg
      361 agctcggcct gcaaaaactc ttggttaggc acatctttct tgtatttgag gtcatgctcg
      421 atacttgccc agctatccat cgcgatggtg cgaagttgaa cttcgacgca catgcgacgg
      481 ccgaattcga agtgattatc gccagtctgc gcttcggccc cctttgactc gacggcatcg
      541 aatgtgcccg atgtattcag ttggtcgata agctgcgaca gggaaatctc ttgcgcttca
      601 atggccgcct tggccgcggc tcgcctcgtt gcatcggggt cgagttccga atcgttcgtg
      661 cgcgcaagaa tcatgtggta gctgcgatat ccgtttggct ttgggtgcaa aatgtagtct
      721 ttttcctgca cgacctcgaa gcatgggagc tcgcgaatga actgcgcgac cgatgcgacg
      781 tcgtcgacga gtgggcaaat cacgcgcacg ccagctgcat catgcacggc gtatacggca
      841 ttttcggcag taggctcgta tcctcgcttg atgagctttt ccctcatgct gtcgggcgac
      901 ttgatgcgcg ttttccacga tgaaataggc ttgcgctcgc ggtttatgcc gcgctccatt
      961 aaatacgtct cgagagatat ctcaaaacgc caggtaattt cctttagttt ctgtaagtaa
     1021 tcgccgtaga aatcggcatc gggcggcaaa tcgattgagg gaagagattg ttcttcggcc
     1081 tcggtggtgc ctggatgggt ttcgacgtgc tgctgcgtgc cgatgggttg aagagtgctc
     1141 gatggctgca tgtaagcttc ctttccgcgc acctactatg gtacctggcg gctcacgcgc
     1201 gaaccgttgg ggcgatgcgg gcgttgccaa tccgatgcct ggcgttcaga tgctggcaag
     1261 gcacttgaat acgaggtgtg tggaatgttt taccagtggc gcgacttggg atgggtttgc
     1321 gtttagcggc gcgggtcctc gggaaagggg tcgtcgatca ttcgtggcca gtgataatcg
     1381 tcgcgttcaa gcatgaacag ttcgagcaac gtggatgcga tgccagctgc gccgtcgtag
     1441 aaaccgatgc gctgcgagag ctcttcgggg tgcactcgct cccatgcgaa aggccaagag
     1501 gccgacccat cggcgtgcgt tttcatcgag cccagcaata tatcgccgca gcgtatggcg
     1561 aactcgcgcc agcgtggcga cccatcgatg cagtagagac ccaagaatgt atgcgccatg
     1621 ccggcgtgac cgcagcagta gcatacggta ttccagaggc cagccgacat atgctcgggt
     1681 gcgccgagcg cttcggctcc gtcggcgagt tgattgacca tcgttgccca acgaatatcg
     1741 ttgtcgaggg tccccatcag ggtggggaag cgcaatgttc ctgcgatgcc gtggcaatat
     1801 cccaagtaga agacggtgaa ttcgtcatct ccgcccaatt tgtgggggat gagcttgcct
     1861 cgtttttgcg gcacggctac ggcgtcgagg aaatcggcgc atctgcgtgc aacttcaaga
     1921 taacgggcat cgcccgtgat gcggaaaaga tgcgcgagca gatatcccga tccagcactc
     1981 ccgaaggcga aattcggcca atcgaatggg gtttcgatgc ccgcgccgtt gaaatcgacg
     2041 ccgccgcgcg ggctttccgc gccccagcgc aggtattgtg cgccagcggc cttgatgaat
     2101 tcaagcaact gctgatcgcc gaacgtttcg tagagtgcga tgaggaatag cataatgccg
     2161 ccgtccatca gtaacgcggg gctgccggtc caataggggc cgctttcgcc ttgttgcaca
     2221 gattcgtcgg tatagaagcg tccgattgct tgtgccgccc ggcgatactt ttcggcgtct
     2281 ctgctttccg cgaaggtttt agcgccttcg atgagcacga ggcccacacc gccaacgccc
     2341 atgtgggcgc ctaggtgtac gccaggcacg ccctcgcggt tatcttggaa ggcggcctgc
     2401 tcgggaagca gcaggtcgcg ccaatgcgcg gctgcgtagg aaagcccgca gcgtgctttc
     2461 tcggcgaact cggcgttgcc ggtgacctcg gtgagtttca gatagaaata cgctacaccg
     2521 gccgacccgc tgtacagcga taggtcgatt ggctggctcg cgtcctgctg ccagaagatg
     2581 ccttcgggcg tcctgtgctc gaaggttgca atccaacgtt cggccgatag cgccgcattc
     2641 aggtaatcac ttgcgttttg cgcgtgatgt gttgggaacg gctttccggg ggtgtaggcc
     2701 atgtcctgcg gcgtctgatt cgattcgatt gagcatgctt cgcacatggt gcttcctttg
     2761 acttcctcaa tatttttcac gaggacattg tgacgcagcg aggctttgtt tgacgaaaat
     2821 ttttcgcttg ccaattgttt ggcgcccgta tttggatgct tcgcggccag tggcgcgcgt
     2881 tttcgctgcg agcagctgac tggtttccgc tcgcagcgaa aagttgtctg ttcgcaactc
     2941 acgcaactgt tttgtgaaat tcgttcactt tatcgcatta aagtgcgata gccccttgca
     3001 cttggggtcg cgccccgtat aatcaacgtc actcaataaa tgcgacgaca gggcgagtag
     3061 gaacgaaccc atcccacagc aagcaggcgg actgagaacc tgcggtggac ggctccgaaa
     3121 actccctcga gcagcgaagc tgaacgcagc tggtcaacgc ggaacaccca ccgcgcgcca
     3181 ccgtcagtat gcaacgccgg cgccttccgt gataaggcat cgagagcgaa gtctcttcgg
     3241 tcgaccgcat tccttgggtt agcgataacg cttgaaggaa gaaggaagaa acgatgcaac
     3301 ttcgtagcga tgccgttaaa gttggcgtgg cgcgtgctcc ccaccgcagc ctgctgaagg
     3361 ccgacggcct taccgatgaa gaaatgaaga agcccctcgt cgcggtgttc aattcccgca
     3421 acgatattat tccgggccac aataacctcg ataaaatttg cgaagctgtg aaggccggca
     3481 tttatatggc cggtggcgtt ccgttcgaaa tttccaccat cggcgtgtgc gacggcattg
     3541 ccatgaacca tgacggcatg cattactcgc tcgtttcccg cgaagctatc gccgacagct
     3601 tcgaatgcgc tgttcaaggc catcaattcg atgctgccgt atgcattccc aactgcgaca
     3661 aaatcgttcc tggcatggtg ctcggcgccc tgcgcgtgaa cattcctacg gttttcgttt
     3721 ccggcggccc catgcttccc ggtcatgaag ctggttgcaa ctgcggtccc acgaccgatc
     3781 tgaacaccct gttcgacggc gcgggccagg tgagtgctgg cacgatgacc gaagagcagc
     3841 tcaagtacta cgaagacacc gcatgcccca cgtgtggcag ctgctcgggc atgttcactg
     3901 ccaattcgat gaactgcctg tgcgaggctt tgggcatcgc gcttcccggc aacggcacca
     3961 ttcctgcggt gtactccgag cgtctgcgct tggcgaagca tgcgggcatg aaagtcatgg
     4021 agctgctcga aaagggcatt tgcatcaagg acatcatctc tgaggcggca atccacaacg
     4081 ccatggaatg cgatatggcg ttcggcggct ctaccaatac ggtgctccat ctgaccgcta
     4141 ttgccatggc ggccggccac cccatcacca tggacgattg ggatgccgca agcgcccgca
     4201 cgccgcattt ggtgaagctg cagccctctg gcccgcgccc gcttatcgac ttgtatgccg
     4261 tgggcggcgt gccggttgtc atgcatgagc tcaacgagct gggcctgctc gacgaaagcg
     4321 cgattacctg catgggcccg cttcccgaat atatcgccaa ctgcaccaag cccgccgacg
     4381 gcgaggtgtg ccgcaaacat gacaatccgt tctccaaggt gggcgccttg cgcgtgctcc
     4441 atggaaacat cgcccctgat ggcggcatcg tgaagaagag cgccgtcgac cccagcatgc
     4501 tcacgcatac cggccccgcc cgttgcttca atagcgagga agaggcttgt gaggcgattt
     4561 tcgctggtga aattaagcct ggcgacgtgg tcgttattcg ctacgagggc ccgaagggcg
     4621 gcccgggcat gcgtgagatg ctcacgccca cgagcgccat tgttggcatg ggcctgtcca
     4681 agagcgttgc gcttctgacc gacggccgct tctccggcgc ctcgaagggc ccctgcgttg
     4741 gccatgtaag ccccgaagcc gcagctggcg gcccaatcgc ccttatcgaa gacggcgacc
     4801 aggtcaccgt tgatattgaa ggcggcaagc tcgagttgca cgtaagcgac gaagagctcg
     4861 ctgctcgccg cgccgctttt gtggcgcctg cccccaagca taaccacggc gtgcttgcca
     4921 agtacgcgaa actcgtttca agcgccgaca agggagcgta tgtctcatga tgaacacctt
     4981 gactgacaag ctgactcaaa agcagctcgc cattgaaggc aagccgcttg gacctggcag
     5041 ccacaccgag cacgagggca aaacgatgac gggcgcccag gcgattatcg cttcgcttga
     5101 ggccgaaggc gtcgacaccg tgttcggcta ccccggtggc caggccatca aaatttacga
     5161 cgcgctgtac gacagcaaga agttgcacca tgtgctcgcc cgccacgaac agggcgccac
     5221 gcacatggcc gacggctacg cgcgcgccac gggcaaggtt ggcgttgtgc tggtaacgag
     5281 cggcccgggc gccacgaaca ccgtgacggg catcgcgacc gcatacatgg attccattcc
     5341 catggtggtt atcactggcc aggtcacgcg cggcgttatc ggcaccgact cgttccagga
     5401 atctgacatt gtgggcatca ccatgcccat cgtgaagcac agcttccttc tgcagtcgac
     5461 cgacgacctt accgagacgt tccgcgaggc attctatatc gcctcgaccg gccgtccggg
     5521 tcccgtgctc atcgatattc cgagcgattt gcagggcgcc gaaatggtgt tccactatcc
     5581 cgatagcgtg aacattccca gctatcgccc cacgtataag ggcaacgcca agcaaatcaa
     5641 gcaggcgacc gcgctcatcg agacctcgaa gcgcccgctg ctctacgcag gcggcggcat
     5701 cgtgagctcc catgcgtgcc aggaattgaa ggcgcttgcg gaagctatgc agattcccgt
     5761 ggtcaccacg ctgctcggta aaggttgttt ccccagctca catccgctga gcttgggtcc
     5821 tgtgggcatg catggctcca aatacgccaa catggccatg acggaatgcg acctcatcat
     5881 tgctgccggc gcccgcttca gcgatcgcgt gaccggaaag cttgatgaat tcgcgccgaa
     5941 cgccaaggtc atccatatcg atatcgaccc ggccgaaatt ggcaagatcc gtgaagcgaa
     6001 cgtgcccatc gtcggcgatg cccagggcat tttgggcggc atcgtggccc agctcgagaa
     6061 atcgggcgct acgcctgtcg atgccgaatg ggtcgaaacg gtaaacgaat ggcgtgagcg
     6121 ctggccgtat tacgacgacc agttcaacga ctatccgaac caaatcgttc ctgaagttgc
     6181 gctcgacgag ctttccaagc agctcgaccc cgacaactcc attgtaacga ctgaggttgg
     6241 ccagcatcag atgtgggctc accagcacat tggccgtgag catgcgcgct cgttcctttc
     6301 gagcggcggc ttgggtacca tgggcttcgg tttccccgct gctatcggcg ccaagttcgg
     6361 ttgccccgac aagcaggttg tgtgtgttgc tggcgatgga tcattccaga tgaacagcca
     6421 ggaaatggcg accgcggcca tcaacaacac cgccgtgaag gtgttcctgc tcgacaatcg
     6481 cgcgctgggc atggtgcatc agtggcagaa gctgttctat cacgagcgct attcgtccac
     6541 gattctcgac ccggtgcccg acttcgtgaa gctcgccgac tcatacggtt gggaaggcga
     6601 gcgcatcgag aagcccgaag acgtggctcc cgcgattgcg cgcatgcttg cgagcgagaa
     6661 gccgtatttg ctcgatgttg ccatttcgcc cgaccagaac gtgtatccca tggttgcgcc
     6721 gggcgctgcg cttgacaacg tgattggcgc gattgacgtt acgcttggcg ctgttcgcgt
     6781 gaatggcaag ggcgtcggca agaaggacga aaaggagggc gaggaataat gaagcacatc
     6841 ctttccgtgt tggtcgaaaa caagtcgggc gtgctctcgc gcgtgactgg catgatttca
     6901 cgccgtggct tcaacattga gtcgcttacc gttgccccta ccgaagattc tacgatgagc
     6961 cgccttacag caatcgtgaa cgccgacgag gttggctacg agcaaatcac caagcagctg
     7021 cacaagctgg taagcgtgta caagatcacc gacctcaccg acgaagacgc tatcgagcgc
     7081 gaactagcct tgttcaaggt gagcgcaccg cccgaccgcc gtcacgagat tatcgagatt
     7141 gcgaacgtct tccgagccaa tatcgtggac gtgggcaaaa actcgctcac gattgaggcg
     7201 acgggtgacg aaagcaagct tgaggcgatg gaggatctct tccgagccta tggcctgaag
     7261 cagctcgttc gaactggcaa aatcgccatg tcgaggaatt cgaaggacta gattgggccg
     7321 attcctcagc gcattggccg ccttgctggt cgaatgattt gcaagaaggg ttgcgttagg
     7381 gaaggaaaac gcgcgacgca gctttgagct gcatcgttgc gagttttgag accatggagg
     7441 gcttttggcg tgcgggggtg cgcaatgcgc agttccgcac gagccgaaca gcacatgaag
     7501 tgctgttcgt gcgagctcag gactgtttga gcacatgcgt atccccgcac gccaaaagcc
     7561 cgatgggatg atcaagttgt atacagtcaa agaaaaggag aaacccatgg ctgttactat
     7621 ctattacgaa aatgacgtga accccgaagt catcaagggt aagaaggttg cgattatcgg
     7681 ttatggctcg cagggccatg cccatgcgct caacctcatg gactcgggcg ttgacgttcg
     7741 cgttggcctg cgcgaaggct ccaagagctg ggctaaggct gaagaagctg gcctgaaggt
     7801 catgctcgag gacgaggctg ccgaggaagc tgacgtcatc atgattctta ttcccgatga
     7861 gctgcagccc gaggtttacg agcagcacat cgccccgcac ctgcatgctg gcgatacgct
     7921 cgctttcgcg catggcttca acatccacta tggctacatc aaggctcccg aggacgtcaa
     7981 cgtcatcatg tgtgccccca agggcccggg ccacattgtg cgccgtcagt tcaccgaggg
     8041 ctctggcgtg cctgacctcg catgcgtcgc tcaggacgct actggcgatg cgtgggatat
     8101 cgccatgtcc tattgctggg gcgtcggcgg tgcccgttcc ggcatcatca aggcgacttt
     8161 cgcgcaggag accgaggaag atctcttcgg cgagcaggcc gttctttgcg gcggcctcgt
     8221 tgagcttgtg aaggccgggt ttgaaaccct gaccgaggct ggttatccgc ccgagctcgc
     8281 gtacttcgag tgctatcacg agatgaagat gattgtcgac ctcatgtacg agtcgggcat
     8341 tcacttcatg aactactcca tctccaacac ggctgagtac ggcgagtact acgctggtcc
     8401 gaaggtcatc aacgagcagt ctcgtgaagc catgaaggaa atcctcactc gcatccagaa
     8461 cggcgagttc gccaaggaat tcgttgccga ctgcaagaac ggccacaagt ggctcttcga
     8521 gcagcgcgag gctatcaaca atcacgagat tgagaagacg ggcgcgaaga ttcgcgacat
     8581 gttctcttgg gtcaagagcg acgaagagta agtacgacgc gcattaaaaa aggggcttat
     8641 aggacaaaaa gtgtgtctcg atagaacgca tgttcctctc acgctaat
//
