LOCUS       c00012_NZ_VICB..       12371 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_VICB01000012.1 Actinomyces johnsonii strain CCUG 34287
            CCUG34287T_0000012, whole genome shotgun sequence.
ACCESSION   NZ_VICB01000012
VERSION     NZ_VICB01000012
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 00:34:48
            Original ID  :: NZ_VICB01000012.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12371
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12371
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3675:7019]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3676..7019
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..12371
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12371
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             195..1505
                     /locus_tag="ctg12_1"
                     /transl_table=11
                     /translation="MQQSDVVLHLGRLMLAAGAGSYRIKSSMARAAAAVGLDRHEATVT
                     MTEIVTSSYVGSRFRTEASEVRRVGVNVDRLEALRRIVHDLRPHETVEHLEAKLRQVEK
                     MHARYNAFTNAAASGVACAGFCFLNKGGWVECLTVLVAAFLGQFVRRQMLERHYQHFFT
                     WLVCGVAASGTYMGIVTALDAAGVVTGNHQGGIISAILFLIPGFPMVTAMLDLFRQDFS
                     SALSRSAYVLMVMAAAGVAVWTVTFIFRWDVAAASGASLDGPLLYVLRCFCSFIAAYGF
                     AMLFNAGSKASILAAVVGALANTGRLLLIDVFHVPWQLAVGLAAVTIGLLAQLFVSRAS
                     LSRVALSVPAVVIMIPGVPFYRAISALNTLSVDKGVDVGEAATNLSEVFFVITAIGVGL
                     ALARIITDHNWRHDVATSERITLPRDTAKATGEQKKD"
     CDS             complement(1603..3378)
                     /locus_tag="ctg12_2"
                     /transl_table=11
                     /translation="VVTTVLHYLLDNPVVIVLLMVGAGLLLWRARRRSIRIPATVLLAA
                     STALLGWKVAHANILHHLSENVVLVLFLLVGTGMLLGHVKIKGVSLGAAAVLFCGIGLA
                     AWGASSSTPIEVPRELGTLGLAIFTFAIGIQSGPNFFHIIRTAGGPLAILLGVLGVAAL
                     AAVGVGRLLGLKAAMIAGAFAGAVTNTPALAAAGNAAAMAGDKAGPGDATVAYAVTYLY
                     GVIGMLFFCLLALRYRRSDKDTPSPLINRTIRVEREDGPILGNIVETTSGQLRFSRLRR
                     GEEGPITRPTNDDRLFKDDLITVVGTQEAVNQAIKAVGHGSSHSLIEDRKYLDFRRITV
                     SDPKLAGRTIGELDIDNRFGATISRVRRGDVDMVGTPNLVLQQGDRVRVVGPTGRMKEI
                     STYFGDSSRGLSSINPVALGLGMALGIFIGEWKFLTPTGATFSIGSAAGTLLVGLIFGR
                     IGRIGKFVTAMPFTATAVLSEFGLLVFLAQAGTKAGGEIAHAFTGGDWWRIFVTGFVVT
                     TIVGLGIYASMRWVVRMGGTRLSGLIGGVQTQPAILAFANERTGADPRVALGYAMVYPV
                     AMIVKIFIAQILGGL"
     misc_feature    complement(3349..3351)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="gutsmash"
     CDS             3676..5460
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_3"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7e-52, bitscore:
                     164.7, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRDDAPARQGQQVMTGAQALVRALEELGVTDIFGMPGGAILPFY
                     DPLLASTRIRHVLVRHEQGAGHAAEGYAMVTGRPGVCVATSGPGATNLITAIADAHMDS
                     VPILAITGQVGSRGIGTDAFQEADIVGATMPFVKHSFLITHPEDIVPRVAEAFHIASTG
                     RPGPVLIDISKDAQEGVTEFVWPPARDLPGYRLPGKPNQRRLAQAAEVIAAADRPVLYL
                     GGGLNRAQVPSNDLTELIELIGAPFVTTLTALDVMPSEHPLNLRMPGMHGTVAAVGALQ
                     RADVIVCLGARFDDRVTGRPDTFATRASVIHVDIDPAEISKIRTADVPIVGDLTDVVPA
                     LSTEFRDHVSAEGRADIAPWRREVERIQATYPTDWTDTDDGLLQPQEVITHLNRAAAED
                     TIWVTGVGQHQMWSAHYLTFRRPHSWLTSAGAGTMGYGLPAAMGAKEACPDRPVWLIDG
                     DGCFQMTNQELATCTLNNIPIKVAVINNSSLGMVRQWQTLFYGQRYSNTDLHTGAGTKR
                     VPDFVKMAEAYGAVGLRCERLEDLDDVIAQANAINDRPVVVDFIVSADAQVWPMVAAGV
                     SNDEIQHARGMSPVWEEE"
     CDS             5466..5978
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_4"
                     /sec_met_domain="ALS_ss_C (E-value: 4.2e-30, bitscore:
                     93.3, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VSEKHTLSVLVENKPGVLTRVSALFTRRGFNIHSLAVGPTEHEDI
                     SRITVIADAEGLAMEQVTKQLNKLVNVLKIVELDPDTSVERELYLIKVHADDANRTAVL
                     QVVDLFRAHVVDVAPTSVVIETIGSESKVKALLTALQPYGVKEIVQSGAVAITRGPRSI
                     TDQLKEK"
     CDS             5988..7019
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_5"
                     /sec_met_domain="IlvN (E-value: 2.9e-80, bitscore: 257.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.4e-67, bitscore: 215.2,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAEKFYDDDADLSVIQSKKVAVIGYGSQGHAHALNLRDSGVEVV
                     VGLREGSSSVAKAEEAGLPVKPIAEAVAWADVITVLAPDQVQAALYREEIEPNIKAGSA
                     LLFSHGFNIHFDYIKPAADIDVVMVAPKGPGHTVRREFEAGRGVPVLVCVEQDATGTAW
                     DLVLSYAKAIGGTRAGAIKTTFREETETDLFGEQTVLCGGVSKLIQYGFETLVEAGYQP
                     EMAYFEVCHEMKLIVDLINEGGISKQRWSCSDTAEYGDYVSGPRVITPDVKEHMKGVLA
                     DIQDGTFAKRFMDDQAAGAPEFKKLRAEGEAHPIETTGREVRSMFAWRADVDKDYTEGS
                     VAR"
     CDS             complement(7114..8364)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 80.4; E-value: 3.9e-25)"
                     /gene_kind="transport"
                     /locus_tag="ctg12_6"
                     /sec_met_domain="MFS_1 (E-value: 6.3e-26, bitscore: 80.4,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRVGLLVLGSFINSLGTGLSAFGLAVIMLRAYGTASSVSAVQMS
                     AFAPIVLLAPLAGVLADRYDRRLMMIIGDAGSVLGLGIILAALASPRPSLAWVCTGAIL
                     SSCLAALTEPALRASVTDLVTEEDYVRASGLLQLASAAKYLLAPAAAGFLMPVVGVRGL
                     VLLDASTCLVTVVCTMTVRRSLAADAPQRAATQPSDDHGFLAGWRTITSSPGLRLLVIL
                     MTLATLAIGVIQVLIKPILLPTVSTSEMGVIETVAAIGMLVGAALVTAWKSAQPTTLLT
                     TGLAATGIAMILVPLGPGAWWVAACGFLTFASLPLSQAGAEVLVRTRVDNARQARTWGT
                     ISLVTQMGYLVAYLCSGVLVDRVLQPLLEPGQALSTSVGTVVGSGPGRGAALLVGIMGL
                     GMVLVALGVHTRRRQLA"
     CDS             complement(8361..8981)
                     /locus_tag="ctg12_7"
                     /transl_table=11
                     /translation="MTRTHRPTAQRREEILDAAHTLFTTKGFQPTTMEDILKVVGIAKG
                     TLYYHFPSKEQILRALVLRIVGQVEQRAREVADSSAPAVDKLVTIMAAMRVEAAQTELV
                     EQFHAPGNAEFHLLSITAMIEHLTPVLADVVAQGVNEGIFTTDRPHDAVELLLSASGIL
                     LDHEIMEPSPDELVRRRESLIWASETLLGARPGSLSALVEVDS"
     CDS             9112..10170
                     /locus_tag="ctg12_8"
                     /transl_table=11
                     /translation="MTQTIKLAVIPGDGIGKEVVPEGLKVLDRALEASGITVLPTTFDL
                     GAERWHQTGQTLTDEDLEAIKGHDAILLGAVGDPSVPSGVLERGLLLRLRFALDHYVNL
                     RPSVYYPGVPTPLADPGDIDFVVVREGTEGLYCGNGGVVRQGTAHEIATEVSVNTAYGV
                     ERLVRYAFAKAQARAAKHLTLVHKHNVLVHAGGLWRRIVEAVGAEYPEVVVDYCHVDAA
                     TIYMVTDPGRFDVIVTDNLFGDILTDEAGAVTGGIGLSASGNINPERAFPSMFEPVHGS
                     APDIAGQGKADPTATISAVALMLDHLGLVEVAARVEAGVKADMAARGDGTDRTTSQIGD
                     AIAAAVTQTAQG"
     CDS             10434..11540
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg12_9"
                     /sec_met_domain="Aminotran_4 (E-value: 2e-29, bitscore:
                     92.4, seeds: 70, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VPEADAIAGRFPLTANPSPVAEDERQAVLAGLHFGDRFTDHMAHA
                     RWRQGEGWGDYGVIPYGNLSLSPATAVLHYGQEIFEGIKAYRHDDGSVWTFRPRYNAAR
                     LNASARRLALPELAEEDFVASLVDLVRADAAWVPSGEGESLYLRPFAFASEAFLGVRPS
                     KVVDYYVIASPAGSYFTHGLEPISIWVTTEYHRAGRGGTGAAKTGGNYASSLLPQQEAY
                     AQGCDQVCFLDDVSQKNLEELGGMNIMVVDADGTVRTPRLTGTILEGSTRSAIIRMLQD
                     SGRRVVEDIISLEGLLADIESGRVREVFACGTAAVVVPLGHLKGKGFDARIEGNEVTRQ
                     VHDRLTSIQSGRAEDPYGWMYQLVPPRS"
     CDS             complement(11978..12370)
                     /locus_tag="ctg12_10"
                     /transl_table=11
                     /translation="LTSMPGIGVRTSAILAGRDPGQGPPGTGAQLASYAGLAPVTRKSG
                     SSIRGEHVSHGGNKRLKRAMFPSAFASLRSDPVSRAYYQRKRDQGKRHNQAVLALAHRR
                     ILTLHAMIRDGALYDPQPATKLPTAA"
ORIGIN
        1 gccggccccc caccccccac ccctcacctg ccaccaccaa cccccaaccc ccaaaaaaca
       61 ccaacaccgt gccgggtcca tggatgatct gacacgaggg cgtcaaacgg tgcaccattg
      121 tcttcgtgac tgacactgat ctccctccca cctccccgca cggccatgag ccgagcctcg
      181 acgcggatcg gctcatgcag cagtcggacg tcgtcctgca cctagggcgt ctcatgctcg
      241 ccgcgggggc cggctcctac cgcatcaagt cctcaatggc gagagcagcc gccgcggtcg
      301 gtcttgaccg gcacgaggcc acggtgacga tgaccgagat cgtcacctcc tcctacgtcg
      361 gtagtcggtt ccgcaccgag gccagtgagg ttcgtcgtgt cggtgtcaat gtcgaccgct
      421 tggaggctct gcgcaggatc gttcacgatc tgcgcccgca tgagactgtt gagcatcttg
      481 aggccaagct gaggcaggtc gagaagatgc acgctcgtta caacgccttc accaacgcgg
      541 ccgcctccgg ggtggcctgc gcaggattct gctttctcaa caagggcgga tgggtcgagt
      601 gcctcacggt cctcgtggcc gcgtttctgg ggcagttcgt ccgccgtcag atgcttgagc
      661 gccactatca gcatttcttc acctggctcg tatgcggggt cgccgcctcc ggcacctata
      721 tgggcatcgt gaccgcgctt gatgcagccg gcgtagtcac cggcaaccat caaggtggca
      781 tcatctcagc gattctgttc ctcattccag gttttcccat ggtgacggca atgctggatc
      841 tgttccggca ggacttctcc tcggcgttgt cgcgcagcgc ctacgtgctc atggtgatgg
      901 cggctgcggg cgtggccgta tggaccgtca ccttcatctt tcgctgggat gtggcggcag
      961 ccagcggtgc ttcgctcgac gggccgttgc tctacgttct gcggtgcttc tgctccttca
     1021 tcgcagccta cggctttgcc atgctgttca acgccggttc caaggccagc atcctggccg
     1081 ctgtggtcgg tgcactggcc aacaccgggc gcctcctcct catcgacgtc ttccatgtgc
     1141 cgtggcagct tgctgtgggg ctggccgcag tcacgatcgg actgctggct cagctcttcg
     1201 tatctcgtgc ctccctgtcc cgggtggcgc tctccgttcc cgctgtcgtc atcatgatcc
     1261 ctggtgtgcc gttctaccgc gccatctccg cgctcaatac actgtcggtc gataaagggg
     1321 tcgacgtggg agaggctgcg acgaacttgt ccgaggtctt tttcgtcatc acggcgattg
     1381 gtgttgggct cgccttggcg cgcatcatca ccgaccacaa ctggcgccac gatgtcgcca
     1441 cctccgaacg catcacgctt cctcgagaca ccgcgaaggc gaccggggag cagaagaagg
     1501 actaacgagg gccgtgtacc cgagcaaacg atggtgcccg ccactgaata cagcgggcgg
     1561 gcaccattgc gtgcgggctc aggcgcgggt caggtgaaga ggctagagcc cgccgaggat
     1621 ctgagcgatg aagatcttga cgatcattgc gacgggatag accatcgcgt agcccaatgc
     1681 cacccgaggg tcggcgccgg tgcgctcgtt ggcgaatgcc aggattgccg gctgggtctg
     1741 gacgccgccg atgaggcccg acagacgagt tccccccatc ctgacaaccc atcgcatgga
     1801 agcgtagatc cccagtccca cgatggtggt gacgacgaaa ccggtgacga agatcctcca
     1861 ccagtcgccg ccggtgaatg cgtgtgcgat ctctccacct gctttggtac ctgcttgtgc
     1921 aaggaagacc aggagtccga actccgagag caccgccgtt gccgtgaacg gcatggcggt
     1981 cacgaacttt ccgatgcggc caatacggcc gaaaatgagc ccaacgagaa gcgtgccagc
     2041 ggctgacccg atagagaaag tggcgccggt gggagtgagg aatttccact cgccgatgaa
     2101 gatccccagg gccatgccca gccccagggc gaccgggttg atggatgaca agccgcgcga
     2161 tgagtcgccg aaataggtcg agatctcctt catgcgaccg gtcgggccga ctacgcgaac
     2221 ccggtcaccc tgctgaagca ccagattcgg ggtccccacc atgtcgacgt cgccacggcg
     2281 cacacgtgag atcgtcgccc cgaaacggtt gtcgatgtcg agctcaccga tggtgcggcc
     2341 ggccagcttc gggtccgaga ccgtgatgcg gcggaagtcg aggtacttgc ggtcctcgat
     2401 gagggagtgt gacgaaccgt ggcccactgc cttgatcgcc tggttgacgg cctcctgcgt
     2461 accgacgacg gtgatgaggt cgtccttgaa caggcggtcg tcattggtcg gtcgggtgat
     2521 gggcccctcc tctccgcgac gcagacggga gaatctcagc tgtcccgagg tggtctcgac
     2581 aatgttgccc agaatcggac cgtcctcgcg ctccacccga atggtgcggt tgatgagcgg
     2641 ggagggcgtg tccttgtcac tgcggcggta gcgcagtgcc aacaggcaga agaacagcat
     2701 gccgatgacg ccgtagaggt aggtgacggc ataggccacg gtggcgtctc ccggtccggc
     2761 cttgtccccg gccatggccg cggcgttccc ggccgccgcc agagctggtg tgttggtgac
     2821 ggcgccggcg aacgcgcccg cgatcatcgc cgccttgagg ccgagaagac gccccacgcc
     2881 cacggctgcg agcgccgcga ccccaaggac gcccaggagg atggccaacg gaccaccggc
     2941 ggtacgaatg atgtggaaga agttcggccc ggactggatg ccgatggcga aggtgaagat
     3001 cgccaatccg agggttccca gctctctggg gacctcgatg ggagttgagg aggacgctcc
     3061 ccaggccgct agtccgatgc cgcagaatag gaccgccgcc gccccaagac tcacaccctt
     3121 gatcttgacg tgtcccagca gcatcccggt gccgaccagg aggaacaaga cgaggactac
     3181 gttctcggac aagtggtgca ggatattggc gtgcgccacc ttccagccca ggagagccgt
     3241 gctggcggcc aggaggaccg tcgccgggat gcgtatgctt ctgcgcctgg cgcgccagag
     3301 cagcagcccg gcaccaacca tgaggagcac gatgacaacc gggttgtcta acagatagtg
     3361 caggacagtg gtgaccacgt cgctgtgccg ccttccgtct cgccgctgaa agtgacgcgg
     3421 cggatgtttg tcatgagtaa cagggttatt gtgtcatctc tgacggggct catggtgtac
     3481 caaggtccgg gactcgtcgg ccggaaagaa tcccgacaga agcagtgagg gacggggctc
     3541 tccttgggcg acccgcgtcc gtgattccac gatgcgagac aacaggtgtc tcgatatgac
     3601 tctctgtgaa cactgatcta acgttcatta cccggcaggt cgccggacgg taagcacgga
     3661 gaaggagagc gagcgatgat ccgcgacgac gctcccgcac gtcagggcca acaggtcatg
     3721 acaggcgccc aggctctggt gcgcgcattg gaagagcttg gtgtcactga catcttcggg
     3781 atgccgggcg gtgccattct gcccttctat gacccactgc tcgcctcgac gaggatccgg
     3841 cacgttctgg tgcgccacga gcagggcgcc ggccacgccg ccgagggcta cgccatggtc
     3901 accggccgtc ccggagtctg cgtggcgaca tccggccccg gtgcaaccaa cctcatcacg
     3961 gctatcgctg acgcgcacat ggactcagtg ccgatactgg ccatcaccgg ccaggtcgga
     4021 agtcgtggaa tcgggacgga tgccttccaa gaggccgaca tcgtcggcgc cacgatgccc
     4081 ttcgtcaagc attccttcct cattacccat cccgaggaca tcgttccgcg tgtggctgag
     4141 gcattccaca tcgcctcaac tggacgccct ggacccgtcc tcatcgatat ctctaaggac
     4201 gcccaggagg gggtcactga gttcgtgtgg cccccggccc gggacctgcc cggctatcgt
     4261 ctgcccggca agcccaacca gcggcgtctg gctcaggccg ccgaggtgat cgccgctgcc
     4321 gaccgtcccg tcctctacct cggcggtggc ctgaaccgtg cgcaggtgcc ttccaacgac
     4381 ctgacggagc ttatcgagct cattggagcg ccattcgtca ccacactcac tgcgctggat
     4441 gtcatgccca gtgagcaccc gctcaacctg cggatgcccg gaatgcacgg taccgtcgcc
     4501 gccgtcggag cccttcagcg ggcagacgtc atcgtctgcc tgggggcccg cttcgatgac
     4561 cgggtcaccg gtagaccgga caccttcgcc acgagggcct cggtcatcca cgtcgatatc
     4621 gacccggctg agatctccaa gatccgtacc gccgacgtcc cgattgtcgg tgatctgacc
     4681 gacgtcgtcc ccgctctgag caccgagttc cgcgaccacg tctccgccga ggggcgggcg
     4741 gatatcgccc cgtggcggcg cgaggtcgag cgcatccagg ccacttaccc cacggactgg
     4801 accgacaccg acgatggact gcttcagcct caggaggtca tcacccacct caaccgggcc
     4861 gccgcagagg acaccatctg ggtcaccgga gtgggacagc atcagatgtg gtcggcgcac
     4921 tacctcacct tccgccgccc ccactcctgg ctcacctccg caggcgccgg gaccatgggc
     4981 tacggcctgc ccgccgccat gggcgccaag gaggcctgcc ccgaccgtcc agtgtggctc
     5041 atcgacggag acggctgctt ccagatgacc aaccaggagc tggccacctg caccctcaac
     5101 aacatcccca tcaaggtcgc tgttatcaac aactcttcgc tgggcatggt gcggcagtgg
     5161 cagaccctgt tctacgggca gcgctactcc aacaccgacc tgcataccgg ggccggaacg
     5221 aagcgggttc ccgacttcgt caaaatggcc gaggcctatg gggccgtggg actgcgatgc
     5281 gagcgcctgg aggacctgga cgacgtcatc gcccaggcca atgccatcaa cgaccgcccc
     5341 gtcgtcgtcg acttcatcgt ctccgcggac gcccaggtgt ggcccatggt cgccgccggg
     5401 gtttccaatg acgagatcca gcacgcccgt ggcatgagcc cggtgtggga agaggagtga
     5461 aagccgtgag cgagaagcac acgctgtccg tcctggtgga gaacaagccc ggtgtcctga
     5521 ccagggtgtc agcgctgttc acgcgtcggg gcttcaacat ccattccctg gctgtcggac
     5581 ccaccgagca cgaggacatc tcgcgcatca cggtgatcgc cgatgccgag gggctggcta
     5641 tggaacaggt caccaaacag ctcaacaagc tggtcaatgt ccttaagatc gtcgagctgg
     5701 atcccgacac ctccgtcgag cgcgagctct acctcattaa ggtgcacgcg gatgacgcca
     5761 accgcactgc ggtgctccag gtcgtcgacc tgttccgcgc ccatgtcgtc gacgtcgccc
     5821 ccacgtcggt ggtcatcgag accatcggct cagaatccaa ggtcaaggct ctgctgacgg
     5881 ctcttcagcc gtacggcgtc aaagagattg tccagtccgg tgccgtggcg atcacgcgcg
     5941 gcccacgatc catcaccgat caactcaagg agaagtgaga agcaatcatg gcagctgaga
     6001 agttctacga cgacgacgcc gacctgtccg tcatccagtc caagaaggtc gccgtcatcg
     6061 gctacggttc ccaggggcac gctcacgctc tgaacctgcg cgactccggt gtggaggttg
     6121 ttgttggcct gcgcgagggc tcctcctccg tggccaaggc cgaggaggcg ggcctgcccg
     6181 tcaagccgat cgccgaggca gtcgcctggg ccgacgtcat caccgtcttg gcccctgacc
     6241 aggtgcaggc cgccctctac cgcgaggaga tcgagccgaa tatcaaggcc ggctctgccc
     6301 tgctgttctc ccacggcttc aacatccact tcgactacat caagccggct gcggacattg
     6361 acgtcgtcat ggtggccccc aagggccccg gccacaccgt gcgccgtgag ttcgaggccg
     6421 gccggggcgt ccccgtgctc gtctgcgtgg agcaggacgc caccggcacc gcctgggacc
     6481 tcgtgctgtc ctacgccaag gccattggcg gcacgcgcgc cggcgccatc aagaccacct
     6541 tccgcgagga gaccgagacc gacctcttcg gtgagcagac cgtcctgtgc ggtggcgtct
     6601 ccaagctcat ccagtacggc ttcgagaccc tggttgaggc cggctaccag cccgagatgg
     6661 cctacttcga ggtctgccac gagatgaagc tcatcgtcga cctcatcaac gagggcggca
     6721 tctccaagca gcgttggtcc tgctctgaca ccgccgagta cggagactac gtctccggtc
     6781 cgcgcgtcat cacccccgac gtcaaggagc acatgaaggg ggtcctggcc gacatccaag
     6841 acgggacctt cgccaagcgc ttcatggacg accaggccgc tggtgccccg gagttcaaga
     6901 agctccgcgc cgagggtgag gcgcacccca tcgagaccac cggccgcgag gtgcgttcca
     6961 tgttcgcctg gcgcgctgac gtcgacaagg actacacgga gggctccgtg gcccgctgag
     7021 gacctcggag accgcctacg gcggtgcccc cgacggctca ggtcgtcggg ggcaccgccg
     7081 tattgccgca gctgtcgcgg tggagttgcg gattcaggcg agctgtcggc gccgggtgtg
     7141 gacgccgagg gccacgagga ccatgcccag acccatgatg ccgacgagca gtgcggcacc
     7201 gcgtcccggc ccgctgccga caaccgttcc gacactggtg gacagcgcct gccccggctc
     7261 cagtaggggc tgaaggaccc ggtcgaccag tacccctgag cagaggtagg ccaccaggta
     7321 gcccatctgg gtcaccagac tgatggttcc ccaggtccgc gcctgccggg cgttgtcgac
     7381 ccgggtgcgc accagaacct ccgctccggc ttgggacagg ggcaggctcg cgaaggtgag
     7441 gaagccgcag gcggccaccc accaggcgcc cggccccagg ggcaccagga tcatcgcgat
     7501 gccggtcgcg gccaggcctg tggtcagcag cgtcgtcggc tgcgcgctct tccaggcggt
     7561 gaccagtgcc gctcctacga gcatgccgat ggcggcgacg gtctcgatga cgcccatctc
     7621 ggacgtgctt acggtgggca ggaggatcgg cttgatgagg acctggatga ccccgatcgc
     7681 gagggtagcc agggtcatga ggatgacaag gagccgcagc ccgggtgagg aggtgatagt
     7741 ccgccaccct gccaggaagc cgtggtcgtc actgggctgg gtcgctgcgc gctgcggcgc
     7801 atctgcagcc agggagcggc gcactgtcat tgtgcagacc acggtgacca gacaggtact
     7861 ggcgtcaagc aggacgagtc ccctcactcc gacgacgggc atgaggaacc ccgccgcggc
     7921 aggagccagg aggtacttgg ccgcagaggc gagttggagg aggccggagg cgcgcacgta
     7981 gtcctcctcg gtcaccaggt cggtgacgct ggcccgcagc gcgggttcgg tgagcgcggc
     8041 caggcaggag gagaggatgg ctcccgtgca gacccaggcc agggaggggc ggggcgaggc
     8101 cagggctgcg aggatgatgc ccagcccgag cactgaaccg gcatctccaa tgatcatcat
     8161 caggcggcgg tcgtagcggt cggcaaggac tccggccaag ggggccagga ggacgatagg
     8221 ggcgaaggca ctcatctgga cggctgacac cgaggatgcc gttccatagg cgcgcagcat
     8281 gatgacggca agtccgaagg cgctcagtcc cgttcccagc gagttgatga acgagcccag
     8341 aacgagcagg ccgacacgtt tcatgagtcg acctccacga gggcggacag actcccaggg
     8401 cgggctccca ggagtgtctc actcgcccag atgaggctct cgcggcggcg gacgagctca
     8461 tccgggctgg gctccatgat ctcgtggtcc aggaggattc cggaagcact cagaagcagt
     8521 tcgacggcgt cgtggggcct gtccgtggtg aagattccct cgttcacccc ctgtgcgaca
     8581 acgtcggcga ggaccggcgt caggtgctcg atcatcgctg tgatggacag cagatggaac
     8641 tcggcgttgc cgggggcgtg gaactgctcg acgagctcgg tctgagcggc ctcgacccgc
     8701 atcgccgcca tgatcgtcac gagcttgtcc accgccggag ccgacgaatc ggcgacttcg
     8761 cgggcacgct gctcgacctg gccgacgatg cgcaggacaa gagccctgag gatctgctcc
     8821 ttgctgggga agtggtagta gagcgtcccc ttggcgatgc ccacgacctt caggatgtcc
     8881 tccatggtgg tgggttgaaa gcccttggtg gtgaaaaggg tgtgcgcggc gtcgagaatc
     8941 tcctcacgac gctgcgcggt aggacggtgg gtgcgcgtca tgtctcctcc gttcctgaga
     9001 gcgtgcaatc gagcataaga ctaaccgacc gtcggtcgaa acgcgaatgc gccacactcc
     9061 cattatgtgg acttcctgtc tcgcatcgtg accgtgtcct aaggtgacct catgacgcag
     9121 accatcaagc tggcagtaat tccgggcgac ggcattggca aggaggtcgt ccccgagggg
     9181 ctcaaggttc tcgaccgggc gctggaggcg agcggaatca cggtcctgcc gaccactttc
     9241 gatctgggag cggagcgatg gcaccagacc gggcagaccc tcaccgatga ggaccttgag
     9301 gccatcaagg ggcacgacgc catcctgctg ggcgccgtcg gcgacccgtc cgtcccctct
     9361 ggtgttctcg agcgcggact gctcctgcgc ctgcgcttcg ctctggacca ctacgtcaac
     9421 ctgcgtccct cggtctacta cccgggggtg ccgacgccgc tggccgatcc cggcgatatc
     9481 gacttcgtcg tggtgcgtga ggggaccgag ggtctgtact gcgggaacgg gggagtcgtg
     9541 cgacagggca cggcgcacga gatcgccacc gaggtcagtg tcaatacggc ctacggggtc
     9601 gagcgcctgg tccgctacgc tttcgccaag gctcaggcca gggcggccaa gcacctcaca
     9661 ctcgtccaca agcacaatgt gctcgtccac gccggtggtc tgtggcgccg tatcgtcgag
     9721 gccgtcggtg ccgagtaccc cgaggtcgtc gtcgattact gccacgtgga cgccgccacc
     9781 atttacatgg tgaccgaccc cggtcgtttc gacgtcattg tcaccgacaa cctcttcggc
     9841 gacatcctca ctgacgaggc cggtgccgtc actgggggca ttggtctgtc ggcctcgggc
     9901 aacatcaacc ccgagagggc ctttccctcc atgttcgagc ctgtgcacgg ctcggccccc
     9961 gacatcgccg ggcagggcaa ggccgacccg accgccacga tcagcgccgt cgccctcatg
    10021 ctcgaccacc tggggctggt tgaggtggct gcgcgggtcg aggccggcgt caaggccgac
    10081 atggctgcgc gtggtgatgg caccgaccgt acgaccagtc agatcggtga cgccatcgcc
    10141 gccgccgtga cccagacggc ccagggatga acgcatcgcc gcattgaagc gccccggccg
    10201 tcttcgtcgc cgaaatacgt gaacggatgg cccgatgagg acctacaagt cgccggaagc
    10261 ggtaagtctg gccggaatct agctgatggc ccgtctacga gccgggatgt gagaaggtcg
    10321 tgtccgagtt gtggcctcgg cggtagggtg ggcgcatgcc tgagacagac gccgcctcaa
    10381 ccgactccac atccaccaca tccaccgctt tggctcgcgc tgccgaggtt cccgtgcccg
    10441 aggccgatgc gatcgccggt cgcttccccc tgaccgccaa cccgtcgccc gtagccgagg
    10501 acgagcgtca ggcggtcctg gcggggctcc acttcggcga ccgcttcacc gatcacatgg
    10561 cccacgcccg ctggaggcag ggtgagggct ggggcgacta cggcgtcatc ccctacggca
    10621 acctcagtct gtccccggcc accgccgtgc tccactacgg acaggagatc ttcgagggga
    10681 tcaaggccta ccggcacgat gacggctcgg tgtggacctt ccgcccccgc tacaacgcgg
    10741 ccaggctcaa cgcctccgct cggcgcctgg ccctgcccga gctggctgag gaggacttcg
    10801 tggcctccct ggtggacttg gtgcgggccg acgccgcctg ggtgccctcg ggcgagggcg
    10861 agtccctcta cctgcgtcct ttcgccttcg cctccgaggc gttcctcggc gtacgcccct
    10921 ccaaggtggt tgactattac gtcatcgcct cccccgcggg ctcctacttc acccatgggc
    10981 tcgaacccat ctccatctgg gtgactaccg agtaccaccg cgccgggcgc ggaggaacgg
    11041 gcgcggcgaa gacgggaggc aactacgcct cctccctgct cccacagcag gaggcctatg
    11101 cccagggctg cgaccaggtc tgcttcctcg acgacgtctc ccagaagaac ctcgaggagc
    11161 tcggcggcat gaacatcatg gtcgtcgacg ccgacggtac cgtgcgaact ccgcgcctga
    11221 ccgggaccat tctcgaggga tccacccgca gtgccatcat ccgcatgctg caagactccg
    11281 gccggagagt cgtcgaggac atcatcagcc tggaggggct gctggcggac atcgaatcag
    11341 gtcgggtcag ggaggtcttc gcctgcggca ccgctgctgt cgtcgtaccc ctggggcatc
    11401 tcaaggggaa gggcttcgac gctcgaatcg agggcaatga ggtcacccgg caggttcacg
    11461 accgactcac ctccatccag tccggccgcg ctgaggatcc ctacggatgg atgtatcagc
    11521 ttgtaccacc ccgttcatag aatgaccgga tgtcattctt ccgttcattc atgatgggca
    11581 tccggacgtg aatggggaat gcggtctcat tccttaaaaa tatgtggtgc gatatgtgcc
    11641 catggcgcat atccctctgt ctgataccag aaatcacctc ggcaaaagag agcagttccg
    11701 gtagtcccga tagtgctgtc agcgacgtct agatcgattt ttccggcgcc gaatcgacgt
    11761 cgaggatttc cagacgacat cccgatcggg cttggaggat cgcccttttc aggaatcgcc
    11821 acgcatgctc ccgagcaacc ggtgcccgcc ggtcagggaa agatcaacgc cgtctactcc
    11881 ttcctcaagg ccgtaactcg gacggctgcc atggatgagt ccttcaccat cgaccagatg
    11941 cagtccctgg ccctgggggg tgcccctatg tggtgtgtca agcggcggtg ggtagtttcg
    12001 tggctggttg tgggtcgtag agggctccat ctcggatcat ggcgtgcagg gtcaggatgc
    12061 ggcggtgggc cagggcgagg acggcctggt tatggcgttt gccttggtct cgtttgcgct
    12121 ggtagtaggc ccgggagacg gggtcggagc gcagggaggc gaaggcggag gggaacatgg
    12181 cgcgcttgag cctcttgttg ccgccgtggg agacgtgctc gccccttatg gaggagcctg
    12241 atttcctggt taccggtgcc aggccggcgt aggaggctag ctgggcgccg gtgcctggag
    12301 gtccttgccc agggtctcgg ccagcaagga tggcggaggt cctgaccccg atcccgggca
    12361 tggaggtcag g
//
