LOCUS       NZ_KB899599.1          14656 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_KB899599.1 Megamonas rupellensis DSM 19944
            F553DRAFT_scaffold00034.34, whole genome shotgun sequence.
ACCESSION   NZ_KB899599
VERSION     NZ_KB899599.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 00:53:22
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 5527
            Orig. end    :: 20183
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14656
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[15527:19832](+)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14305
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14656
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14656
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(1010..2317)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTS_EIIC"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg34_8"
                     /sec_met_domain="PTS_EIIC (E-value: 3.8e-55, bitscore:
                     177.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKQKLFDSFIEVMSKFAQIRAVVALRDGFIMTTPFTICGSVFLL
                     IANLPIPGYGEFMASIFGNDWTAPFNAVAGGTFNVLALIVVVAITYKFVGNEGCDASMA
                     SILALSTLLILMPPSLVTENGQLVGDIIPKAWVGSNGVITAIIIAFFVSYVFCYCEKNN
                     VGIKMPDSVPQGVARAFTALVPGMIFFTVASVLYGLCHYLGAITLPELIFKIIQTPLQG
                     LSDTLAGGSIIVALQGILFWAGVHGPNVVGGVVSPLLIANSLDNQHLIDIGMSLINNPE
                     AKIITAQVNDVFVKSGGCGLTLGLLLSGIFTVKSQQMKSLLKMAFVPGLFNINEPLIFG
                     LPIVFNPYLLVPFVLVPLIALFVTYFSISMGFMSPFSAVQVPWTTPPIIAGFLLNGWQG
                     AVVQIINLAISTAIYFPFVRAQDKAMLKEEQGEKEE"
     CDS             complement(2565..3407)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SIS"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg34_9"
                     /sec_met_domain="SIS (E-value: 2.3e-14, bitscore: 43.4,
                     seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VTNLIKILQEQKDFSETEIMIATYLLANFRKLAGMSTRQLGKNTY
                     TNSAAIVRFSQKLGFSGYTEFRVQFLAEMMQYINHPKGEELVVSTKDSIHSLIDKVTAI
                     EIDTLKETRNMLNPEDFLKALNLFIKSKHIDFYAMDNNLDIARIASAGFIMANKCSSVH
                     SPMTMQYLQATSASKDHLGFIISRTGNNRMLLDIARLLKLRGISFILITASPNSEIASL
                     ADVVFSVASVKQMEELGPRVFLLGAKYVTDIMFTMLMTRLDYHDSQQKEQWLNKHFRY"
     CDS             complement(3549..4892)
                     /locus_tag="ctg34_10"
                     /transl_table=11
                     /translation="MEILGFIVLIACLVIGVRFGGLGLAAVSGIGLTFFVFVVGLVPGK
                     PPIDVMLTIMAVVTCSGFLQASKGLDVMLKYAEKLLRKNPKQITVLAPITTWFLTVLCG
                     TGHVVYTMFPIIYDIAIKQNIRPERPMAAASVASQMGICASPASVAVVSMVAMLAGTTH
                     PLGVVQILMVSIPATFCGVLVTGLWSLKRGKDLAKDEIFQAKLRDPEQRAYIYEEQAQN
                     NAEVKLPASAYKATFIFLLGIVVIALFGSFPKELLPLVPNAKGAWVPLSMTPTIQLCML
                     VIAALILLICKVKVSDVTNGSVFKSGMVAIVSVYGVAWMAETYFGAYLPEFKETLGQIV
                     LDYPWTYAIVLFLISKLVNSQAAALAIVVPMALSVGVDPLIIISFISACYGYFFLPTYP
                     SDLACIGFDRSGTTRIGRFVINHSFIIPGFIGITVGCCVGYVITHLLY"
     CDS             complement(5059..6018)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg34_11"
                     /sec_met_domain="Radical_SAM (E-value: 5.4e-22, bitscore:
                     68.9, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNCVNDLKEKILNGYRINKQEALDLVKAPLDELSTAANEIRKHFC
                     GDDFDICTIINGKSGRCSEDCKYCAQSAHYTTKIETYPLLNTKPILEEAQYNYSKGVAR
                     YAVVTSGKRLSDEEIDKLANSLDEVHKKCKIKLCVSGGLLNEAQFKKLNDVGVERIHNN
                     LETSRNHFDKVCTTHTFEDKVEAIKAAQRAGMSVCSGGIMGIGETMEDRIDMALEIRNL
                     NVNSVPINRLNPIPGTPYEHNKPLTDEDMQRIVAIYRFILPDLFIRLAGGRGLFTDKGK
                     ACLQSGANAVISGDMLTTSGISIDTDMKMIQELGFKIV"
     CDS             6134..7201
                     /locus_tag="ctg34_12"
                     /transl_table=11
                     /translation="MNSTDILQTHGANLYEITFNLLSNSKLAEFIPNKNSTIIIKPDIK
                     YINNTLYSTSPVILTTIIKYLQDNNFTNINLVLGSLIDDDLEQLLITCKYDKIVDKLNI
                     PVYGLKDKDYTTKTIGGIEYKLIDKVINADFFINLVTSSPNETTILHNALQAMQNILHA
                     QNRSLFTTDNFYKAICFLNYLIKANFTLVEIDSLSDIQADKHMYATIDNLLADAYYAQN
                     LGYKPFDIEYIELASKLNIGCADINKANIINLIDNTITCDNNSKLASHINASSPCEQCY
                     QNLLQALSLLDKDNLLDKLPTKLFIGQGWREFSENGIGIGRCTSKFENYVRGCPPSPQK
                     TYEFLKEFICNNQNA"
     CDS             complement(7275..8447)
                     /locus_tag="ctg34_13"
                     /transl_table=11
                     /translation="MFDKLEEKAMVHFFNKFDKNPFLLKFKDNQYLVGKGEPTFVVDFK
                     KTIPIMDLLNSTSIALGEAYMNGDLTIEGDLYDALIHFLGQMDKFSLNETLLDKIIHPS
                     NSKESQEKQVQSHYDIGNDFYKLWLDETMSYSCAYFKNEDDTLYQAQVNKVDYILSKLY
                     LKEGMSLLDIGCGWGFLLIEAAKKYKVKGTGITLSREQYKEFKSRIQKEHLEDYLTVEL
                     MDYRDLPKWGKSFDRVVSVGMLEHVGRENYQLFNDCVNAVLKDKGLYLLHFISQLKEME
                     TDSWMKKYIFPGGVIPSLREIVSSMGNDDFHILDIENLRRHYEKTLLCWADNFHNHLDK
                     ISGMFDEKFIRMWDLYLNACAANFHVGGIDLHQILVTKGVNNELPLTRWY"
     CDS             9103..9351
                     /locus_tag="ctg34_14"
                     /transl_table=11
                     /translation="MMVIGAEDRNRTGTVITNRGILSPVRLPVPPPRHYSLLCSRREHL
                     ICYHIVLFLSRTFLKFFQTFFDGAGDGNRTHVTSLEG"
     CDS             10001..14305
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg34_15"
                     /sec_met_domain="HGD-D (E-value: 4.9e-40, bitscore: 128.1,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 3.5e-35, bitscore:
                     111.7, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHNNNYLKLIFLISKVLINIYFIGGVILNFSYKLGIDIGSTTIKL
                     VVLDNDNQVVYKKYMRHLSEIYKSMHDNMILLSDTLKNHKFTCAITGSAGMGMANNLNM
                     PFVQEVIACSKAVKNWIPQTDVAVELGGEDAKITYFGSAPEQRMNGVCAGGTGSFIDHM
                     ASLLNTDAMGLNELAQKGTQIYTIASRCGVFAKTDVQALLNDGVSKADIALSILQAVVN
                     QTIGNLAQGRPLEGNIAFLGGPLYFLTQLKERFIKTLKLTDEHIVNVDDGCYFVAMGCA
                     LSDNAIEMTYDELMQRLNNCSKSSTETESVAFTLFKNEQEYNEFKQRHNKDVVKKASLS
                     DYQGPLYIGIDAGSTTTKLVAISKDREILYSSYGSNNGSPLKTVLDEIKALYEIIPPNA
                     YIATVGTTGYGEHIVKAALHADFGEVETFAHLRAAREFCPDVSCVLDIGGQDMKCFYVN
                     KGNIGQIILNEACSAGCGSFIQNFAQGLNMEVSDFANKGLTAKNPVDLGTRCTVFMNSR
                     VKQAQKEGASVNDISAGIALSVIKNALFKVIQVKDVSELGDNIVVQGGTFYNDAVLRSM
                     ELLLNKNVIRPDISGLMGAYGIALLAIERQQEKSSILTKEELKDFHMETKTYRCHGCGN
                     NCLITTQIFPDGNRYSTGNRCEKGIGKQIAKEDKAPNIYKYKYHRLFEYYKPLLNAPKG
                     RIGIPRVLNMYEDFPFWFTFFTLLGYEVVLSGKSSAQLYCKGMSTIPSDSLCYPGKLVH
                     GHIMDLIEKGITTIFYPCIPYNMKDPLHASDNNYNCPIVASYAENIRANMDILRQKNIN
                     FLQPFLPINNKKALIKRLQEELSSLNIPKKDLIEAVEKSYQELDKYKEDIRNYGENIIK
                     EATDKKMPIVVLAGRPYHVDPEINHGIPEMIQSYGIAILSEDALYHLDCPEDSLDIVNQ
                     WSYHARLYHAASYVARHKEMTLIQFSSFGCGLDAITTGQVREILEQHGDIYTMIKLDEV
                     SNLGAARIRIRSLMAAWKYGFAQIDEIEPPKQRAYFSKECQEEHTILAPQMSPKHFDFI
                     QHACKKSGMKIVIPPMPTQEDIDLGLRYVNNDMCYPAIVVIGQLLKALKSGEYDVNNTS
                     IMLFQTCGACRATNYLNLMRKALENAGLSQVPVFACVGRETDDFKLKTEIWLDVVKATI
                     YSDLLIRLSNRTRPYEKVAGSVDVLYNKWRKIFMDEITNGNYIKFSNNIKKAVKEFDEI
                     ALNEDVIKPKVGIVGEILVKYHPTANNHVEKILFDEGAEVVTPDLMDFFMYMAYDDIVK
                     YKMLDGKWIDKAKSEIFIKVLEFFRKPMRKALRASKRFTAPYTIKEIAKLTTPHVSLGN
                     MAGEGWFLTGEMAKLIQEGVDNIICLQPFGCLPNHITGKGMIRELMRTHDGVNIVAIDC
                     DAGISEVNQLNRIKLMLSVAKEKIAEQDHKAL"
ORIGIN
        1 ttgggcatat gctaaattaa tttgtaaatt atcagaaaca ggaccttgta cgcctaatcc
       61 gtacatagca aaatcataac ctgcatcagt tggtttttga taaaatgcta atgcttttaa
      121 accgttatta tctaaaggat aatcaagcac gataccgtct gtttcattac ccaataatac
      181 attttgaaaa cctaaaccgc gccatctgcg ccctacatca acatgcaatt tatcaatatt
      241 accttctgcc caaatacgct ggattacacc atcagaatca tcatgacctt catgatattt
      301 tacatcacca gcggatgtta catatcgagc ataacgttga tttgtttcgc tttcaaaatt
      361 aaaattccaa tcatcattaa ctttaaattt accttttaaa tcaagataaa aacgattatt
      421 atcattttgg tcattataac ctttgatatt gtcattatcc caagatactc taccaaaacc
      481 actaatttta aaacgttctg cgtcttcttt taatttggaa atatcggatg tatttttatc
      541 aatttgtgat tgcatttgct tcaaatcttc gctaaattct tcttttaatt gatttaatac
      601 agctttatct cctatatctc ctttatctga tttcatagca ttagccacta tacttgccat
      661 ttcataacgt gtcattgttc gatttccctg aaatgttcca tctttataac cttcaatgac
      721 accatgttga gctaaataat caagtgcttc ataagcccaa tgaccttgag gaacatcact
      781 aaaactattt acatttgcat ttatattttc attatcagta acactaactt tattttctga
      841 agaaacttta tctgtatcag atgttgattg cgcaaaagat gtacctgtta atcctaaaaa
      901 tattcccata gaaatagcta acgctttatt tttctttaat agcatcaata cattcgcccc
      961 caaaattaat tctctctaat atacaatctc tcaaaaaata atttaataat tattcttctt
     1021 tttcaccttg ttcttctttt aacattgctt tatcttgtgc tcgtacaaat ggaaaatata
     1081 ttgctgtaga tatagccaag tttattatct gtacaacagc accttgccaa ccattaagta
     1141 aaaatcctgc aattattgga ggtgttgtcc atggtacttg aacggcacta aaaggagaca
     1201 tgaagcccat actgattgaa aaatatgtta caaataatgc tattaaaggt actaacacaa
     1261 atggaacgag taaatatgga ttaaatacaa ttggcaaacc aaaaataaga ggttcattta
     1321 tattaaataa acctggcaca aatgccattt tcaacaaaga tttcatttgt tgagatttaa
     1381 cagtaaatat acctgataat aaaagtccta atgtcaaacc acaaccgcca ctttttacaa
     1441 atacatcatt gacttgagca gttataattt tagcttctgg attatttata agagacatac
     1501 ctatatctat aagatgctga ttatctaaag aatttgctat caataatgga cttactacac
     1561 caccgacaac atttggacca tgaacaccag cccaaaacaa aatgccctgt aaagcaacaa
     1621 ttatagaacc accagctaat gtatcagaaa gaccttgcaa tggtgtctga ataattttaa
     1681 aaattaattc tggtaatgta atagctccaa gataatgaca aagtccgtat aaaacagaag
     1741 ctactgtaaa aaatatcata ccaggtacta acgcagtaaa agctcttgct acaccttgtg
     1801 gtacagaatc tggcattttt ataccaacat tatttttttc acaataacag aaaacatatg
     1861 atacaaaaaa agctataata attgctgtta taacaccatt actaccaacc caagcttttg
     1921 gtataatatc tcctactaat tgaccatttt cagttactaa tgatggtggc attaatatta
     1981 acaatgttga taaagctaat atagatgcca tactagcatc gcaaccttca ttgcctacaa
     2041 atttgtatgt aattgcgact acaacaatta aagctaatac attaaatgta ccacccgcta
     2101 cagcattaaa tggtgctgtc caatcattac caaatatgga tgccataaat tctccatatc
     2161 caggaattgg taagtttgca atcaacaaaa atactgaacc acaaatagta aatggtgtag
     2221 tcataataaa accatcacgt aatgctacta cagcacgtat ttgtgcaaac ttgctcataa
     2281 cttcgataaa gctatcaaaa agtttttgtt tatccattta gaattctctc cttttcttat
     2341 acataatttt ttgaattttt cttaaggcga ttttaatata tcattaacaa aatactgttt
     2401 caatagatat tggctaatac gaaacaatga tacaatatca tataaaaaaa ccttttttca
     2461 cttgtagcaa tgatacgaat tgtttgaaaa taatcaaaat aacaacaaaa aactgcttat
     2521 tttaaatgtt atctacatca aaataagcag tttttatttt catcttaata acgaaaatgt
     2581 ttatttaacc attgttcttt ttgttgcgaa tcatgataat ctaaacgcgt cataagcatg
     2641 gtaaacatta tgtctgtaac atattttgca cctaaaagaa aaactctagg tcctaattct
     2701 tccatttgct tcacacttgc tacagaaaaa actacatctg ctaaactagc tatttctgaa
     2761 ttaggtgatg ctgtaatcaa aataaaggaa attcctcgta gttttaataa acgagcaata
     2821 tctaataaca tacgattatt ccctgtacga cttatgataa atcccaaatg atcttttgaa
     2881 gcactagttg cctgtaaata ttgcatagtc attggagaat gtacacttga gcatttatta
     2941 gccatgataa aaccagctga agcaattctt gctatatcta aattattatc catagcataa
     3001 aaatcaatat gtttagattt tataaaaaga tttagagctt ttaaaaaatc ttctggatta
     3061 agcatattcc ttgtttcttt taatgtatca atttcaatag ctgttacttt atcaattaat
     3121 gaatgtatac tatctttagt tgatacaaca agttcttcac cttttggatg attgatatat
     3181 tgcatcattt cagctaaaaa ttgaactcta aattctgtat atccactaaa acctaatttt
     3241 tgactaaaac gcacaatagc agctgaattt gtatacgtat ttttacccaa ttgtctagtt
     3301 gacattccag ctaatttcct aaaatttgct aataaatatg ttgcaatcat tatttctgtt
     3361 tcagaaaaat ctttttgttc ttgtaatatt tttattaaat ttgtcacata aaaccctcct
     3421 atctttattt atatttgtca aaatatagct tatatattaa tattatttaa aattatagtc
     3481 aataaaattt ataatcaaaa aatcctagag cataaactct aggatttttt atttcattaa
     3541 ttaatttatc aatataaaag atgtgttatt acataaccta cacagcaacc aactgtgata
     3601 ccaataaaac ctggaatgat aaagctatga ttgattacaa atctaccaat tcttgttgtt
     3661 ccagaacggt caaaaccaat gcaagccaaa tctgatggat aagttggtaa gaagaaataa
     3721 ccatagcaag cagaaataaa tgaaatgata ataagtgggt caacacctac acttaatgcc
     3781 ataggcacta caatagctaa tgctgctgcc tgagaattta ccaatttaga tattaagaat
     3841 aaaacaattg cataagtcca aggataatct aaaacaatct gtcccaaagt ttctttgaat
     3901 tctggtaaat atgcaccaaa ataagtttct gccatccatg ctacaccata cacagaaaca
     3961 atagctacca taccagattt aaaaacagaa ccatttgtta catcactaac tttaactttg
     4021 caaataagta aaataagcgc tgcaataacc aacatacaaa gctgaattgt tggtgtcata
     4081 gaaagtggta cccatgcacc tttagcattt ggtacaagtg gtaacaattc ttttgggaaa
     4141 ctaccaaata aagcgattac aacaatacct aataaaaaga taaatgtagc tttataagca
     4201 ctagctggta attttacttc agcattattt tgagcttgtt cttcatagat ataagctctt
     4261 tgttctggat ctcttaattt agcttggaaa atttcatctt ttgctaaatc tttacctctt
     4321 tttaagctcc ataagcctgt tactaaaaca ccgcagaacg tagctggaat agaaaccatt
     4381 aaaatttgta ctacacctaa tggatgagtt gttcctgcaa gcattgccac catggatact
     4441 acagctactg aagcaggaga agcacaaatc cccatctgag aagcaacaga tgctgctgcc
     4501 attggtcttt ctggtctgat attttgtttg atagcaatat cataaataat tgggaacata
     4561 gtatatacta catgaccagt accgcaaaga acagttaaaa accatgtagt aattggagca
     4621 agtacagtta tttgttttgg gtttttacgc aataattttt cagcgtattt tagcattaca
     4681 tcaagccctt ttgatgcttg caaaaatccc gagcaagtaa ctaccgccat aattgtgagc
     4741 attacatcaa ttggtggttt tcctggtact aaaccaacaa caaatacaaa gaaggtcaaa
     4801 ccaataccgg atacagcagc taatcctaag ccgccaaaac gaacaccaat aacaagacag
     4861 gcaataagaa ctataaatcc taaaatttcc atacaaaaac tcctttcatt ttgtatacat
     4921 catactaaat acctgttctg aaataataga ttatttatac aatttagtcc ggttaatatt
     4981 ataacataaa aaatttttat tgtataatat tttttatata tagggcaaat ttaattgccc
     5041 tatatatttt taaagtaatt atactatttt aaaacctaat tcttgtatca tcttcatatc
     5101 tgtatcaata gaaatgccac ttgttgtgag catatcacca gaaataacag cattagctcc
     5161 tgactgcaaa caagctttac ctttatctgt aaataatcct ctaccaccag ctagacgaat
     5221 aaataaatct ggtaaaataa aacgataaat agccactatt ctttgcatat cttcatcagt
     5281 aagtggctta ttatgttcgt atggtgttcc tggtatagga tttagacgat ttataggcac
     5341 agaatttaca tttaaatttc gtatttctaa agccatatct attctatctt ccatggtttc
     5401 acctattccc atgataccac cactacaaac actcatacct gctctttgcg ctgcttttat
     5461 tgcttctact ttatcttcaa aagtatgcgt agtacaaact ttatcaaaat gatttcttga
     5521 ggtttctaaa ttattatgaa ttctttctac gcccacatca ttcaattttt taaattgagc
     5581 ttcattcaat aaaccaccag aaacacataa ttttatttta cattttttat gtacttcatc
     5641 taaagaattt gccaatttat ctatttcttc atcacttaat ctcttgcctg aagttactac
     5701 tgcataacgt gctacgcctt tgctataatt atactgtgct tcttctaaaa taggcttcgt
     5761 atttaataat ggataagttt ctatttttgt agtataatga gctgactgtg cacaatattt
     5821 acagtcctcg gaacatctac cagattttcc attaataata gtgcaaatat caaaatcatc
     5881 accgcaaaaa tgttttctta tctcattagc ggctgtagat aattcatcta atggagcttt
     5941 cactaaatct aaagcttcct gtttattaat tctataacca tttagtattt tttcttttaa
     6001 atcatttacg caattcattt gttatcacct taaatctttt atataaatat aattaaacca
     6061 ttatatttat ataatgtcaa cttttaaaaa tattaggtta acgaattata taatcattta
     6121 agaaaggaat tttatgaact caacagatat tttacaaaca catggtgcaa atctctatga
     6181 aatcactttt aatttattat ctaattctaa attagcagaa tttatcccta ataaaaacag
     6241 tacaattatt attaaacctg atataaaata tatcaataat acactatact ctacttctcc
     6301 agtaatctta actacaataa ttaaatacct acaagacaat aattttacta atattaatct
     6361 tgtattaggt tctttaatcg atgatgattt agagcaatta ttaataactt gtaaatacga
     6421 taaaattgta gataaattaa acattcctgt atatggtctt aaggataaag attacactac
     6481 aaaaactatt ggtggtatcg aatataaatt aatagataaa gtcatcaatg ccgacttttt
     6541 tattaattta gttacttctt caccaaatga aacaactata ctgcacaatg cattacaggc
     6601 tatgcaaaat atcttgcatg cccaaaatcg ctctttattc actacagaca atttttataa
     6661 agcaatctgc tttttgaatt atttaattaa agctaacttc acattagtag aaatagatag
     6721 tttatctgat atccaagcag ataaacatat gtatgctact atagataatt tattagctga
     6781 tgcttattat gctcaaaatc taggctataa accatttgat atcgaatata ttgaactagc
     6841 ttctaaatta aatatcggtt gtgctgacat caataaagct aatatcatta atttaataga
     6901 taatactatt acttgtgata ataattcaaa gttagcctct catatcaatg cttctagccc
     6961 ttgcgagcaa tgttatcaaa atttactgca agcactctcc ttattagata aagataattt
     7021 acttgataaa ctacctacaa aattattcat cggtcaaggt tggcgagaat tcagcgaaaa
     7081 tggcattggc ataggtcgtt gcactagcaa atttgaaaat tatgttagag gttgcccacc
     7141 aagccctcaa aaaacttatg aatttctaaa agagttcatt tgtaataatc aaaatgcata
     7201 aagaataaat aaaagctcta taagttaaat actacaaata acttatagag cctctttttt
     7261 attatattaa tatatcaata ccatcttgtt aatggtaatt cattatttac acctttagta
     7321 actaaaattt gatgtaaatc tatgccacct acatggaaat ttgctgcaca ggcatttaaa
     7381 tataaatccc acatgcgaat aaatttttca tcaaacattc cactgatttt atctaaatga
     7441 ttatgaaaat tatctgccca acaaagtaaa gttttttcat aatgacgacg caaattttca
     7501 atatcgagaa tatggaaatc atcatttccc atactagaaa cgatttccct aagacttggt
     7561 atcactccac ctgggaaaat gtattttttc atccaactat cagtttccat ttcttttaat
     7621 tgactgatga aatgcaataa atacaaaccc ttatctttta atactgcatt tacacaatca
     7681 ttgaatagct gataattttc cctgccaaca tgttctagca tacctacact aacaactcta
     7741 tcaaaacttt ttccccattt tggtaaatct cgataatcca tcaattcaac tgttaaataa
     7801 tcttctaaat gttctttttg tatacgcgat ttaaattctt tatattgttc acgacttaaa
     7861 gtaatacccg taccttttac cttatatttt ttagcagctt cgatgagtaa aaagccccaa
     7921 ccacagccaa tatctaatag gctcatacct tcttttaaat ataatttcga taaaatataa
     7981 tccactttat ttacttgtgc ttgatataaa gtatcatctt catttttaaa ataagcacaa
     8041 gaataactca ttgtttcgtc taaccataat ttataaaaat cattacctat atcataatga
     8101 gattgaactt gtttttcttg actttcttta gaattagatg gatgaattat tttatctagc
     8161 aaagtttcat tcaaagaaaa tttatccatt tgacctaaaa aatgaattaa agcatcatat
     8221 aaatctcctt caatggttaa atctccattc atataagctt cacctaaagc gatagacgta
     8281 ctattaagta aatccattat aggtattgtc tttttaaagt ccactacaaa agttggttca
     8341 cctttaccta ctaaatattg attatcttta aattttaaaa gaaatggatt tttatcaaat
     8401 ttattaaaaa aatgaaccat agccttttct tctaatttat caaacataat agcacctctc
     8461 aatatccttc ataaaaaact ataaactact aatataaatt agtagtttaa aatttcacaa
     8521 ataatattat ttttaagtta ctaatatata aatatttgat tagttaactt tatacttata
     8581 ctatacccat ctataactat tgtcaattag ataaaatcta ataagtttga taaaaaattt
     8641 ttaagtttat tttagaaaat aaaaaaatgc tttttaaaat ctagattttt aatctggact
     8701 ttaaaaagca ttcttaaatc tatataaaaa ctctttatta agagttgaat aaccatggtg
     8761 acgcgtatgg gattcgaacc catgaagccg ccgtgaaagg gcggtgtctt aaccacttga
     8821 ccaacgcgcc atatttaaat ttcctacaga cataaaaaaa gctgatatca tattggtatc
     8881 agttcattct ttaaattaat ggtgcggttg atgggacttg aacccatacg accattgatc
     8941 actaccccct caaagtagcg cgtctgccaa ttccgccaca accgcatata ctctttaatg
     9001 gtgcggccga gtggatttga accaccatga ggtatccccc actagcgcct gaagctagcg
     9061 cgtctgccat ttcgccacga ccgcaaaggg caaaaataac aaatgatggt gattggtgcc
     9121 gaggaccgga atcgaaccgg tacggttatt actaaccgcg ggattttaag tcccgtgcgt
     9181 ctgccagttc cgccaccccg gcattattca cttctttgtt ctcgtcgaga acatttaata
     9241 tgttaccata ttgttttatt cttgtcaaga acttttttaa agttttttca aacttttttt
     9301 gatggagcgg gtgatgggaa tcgaacccac gtaactagct tggaaggcta gggctctacc
     9361 attgagctac acccgcattt catggagctg gcgagaggaa tcgaaccccc aacctgctga
     9421 ttacaagtca gctgctctgc caattgagct acaccagcat gttataaaat ggtgcctcag
     9481 agcggaatcg aaccactgac acggggattt tcagtcccct gctctaccga ctgagctacc
     9541 gaggcaaatg gcgacccgaa ggggacttga acccctgacc tccgccgtga cagggcggca
     9601 ttctaaccaa ctaaactacc gggccatctt aacctttatt gctgtttttt ctctgtgagt
     9661 tgttgtctca cgagccagct tctatagtat attattttaa aaccattttg tcaacacttt
     9721 ttttgaaaaa atttaaaaaa agttatcgtt tttatttttt cagattaaac gccattattt
     9781 ttcaacaaaa aacttcctta ttataaatat agtaaaattt atattatcat ctctttttga
     9841 aaataaaatc ttcattttca tcacttattt ctatttaatt ttactttttt attcaatttc
     9901 agctaaaaaa ttcattcttt ttttctaaaa tcaataaaaa aatcctcaaa agtgaatact
     9961 attcattttg gtaaattttt tattctatga tataatacat atgcacaata ataactattt
    10021 aaagcttata tttctaattt ctaaagtatt aataaatata tattttatag gtggtgttat
    10081 cttgaatttt tcgtataaac ttggtattga tatcggttct actactataa aattagttgt
    10141 cttagacaac gataatcaag tagtttataa gaaatacatg cgtcatttat cagaaatcta
    10201 taaatccatg cacgataata tgattttatt atcagataca ttaaaaaatc ataaatttac
    10261 ctgtgcaata actggctctg ccggtatggg tatggctaac aatttaaaca tgccttttgt
    10321 tcaagaagta atcgcttgtt ctaaagctgt taaaaattgg atacctcaaa ctgatgtagc
    10381 tgtagagtta ggcggtgaag atgctaaaat cacttatttt ggctctgcac cagaacaacg
    10441 tatgaatggt gtttgtgcag gtggcacagg ttcatttatt gaccatatgg cttcactttt
    10501 aaatactgat gctatgggtt taaatgaatt agctcaaaaa ggcactcaaa tttatactat
    10561 tgcttctcgt tgtggtgttt ttgctaaaac agatgttcaa gcattattaa atgatggtgt
    10621 ttctaaagcc gatattgctc tttctatctt acaagctgta gttaatcaaa ctatcggtaa
    10681 cttagcacaa ggacgtccac ttgaaggtaa tatagccttt ttaggtggcc ctttatattt
    10741 cttaactcaa ttaaaagaac gctttattaa aactttaaaa ttaactgatg aacatattgt
    10801 caatgttgat gatggttgtt attttgttgc tatgggttgc gctctaagtg ataatgcgat
    10861 tgaaatgaca tatgatgaat taatgcaacg tttaaataat tgcagtaaat catctacaga
    10921 aactgaatct gtagccttta cattatttaa aaatgaacaa gaatataatg agtttaagca
    10981 acgtcataat aaagatgttg taaaaaaagc ttcattatca gattatcaag gacctctata
    11041 cataggtatt gatgctggtt ctactactac aaaattagtc gcaattagta aagatcgtga
    11101 aatattatat tcttcctatg gcagtaataa tggctcacca ttaaaaactg tattagatga
    11161 aataaaagct ctatatgaaa ttattcctcc taatgcttat attgctactg ttggtacgac
    11221 tggctatgga gaacatatcg tcaaagctgc tcttcatgca gattttggtg aagtagaaac
    11281 ttttgctcat ttacgtgcag ctcgtgaatt ttgtcctgat gtatcttgcg ttctagatat
    11341 cggtggacaa gatatgaaat gcttctatgt aaataaaggc aatatcggac aaatcatttt
    11401 aaatgaagct tgctctgctg gctgtggttc tttcattcaa aacttcgctc aaggcttaaa
    11461 tatggaagtc agtgattttg ccaataaagg cttaactgct aaaaatccag tagatttagg
    11521 tactcgttgt actgttttca tgaattctcg tgtaaaacaa gcacaaaaag aaggagcttc
    11581 tgtaaatgat atttctgctg gtatagctct ttccgttatc aaaaatgctt tatttaaagt
    11641 aatccaagtc aaagatgtat ctgaacttgg cgataatatc gtagttcaag gtggtacatt
    11701 ctataatgat gctgtacttc gttctatgga attattgtta aataaaaatg taatccgtcc
    11761 agatatctct ggcttaatgg gtgcttatgg tattgcactt ttagctatag aacgtcaaca
    11821 agaaaaatct tctattttaa ccaaagaaga attaaaagat ttccatatgg aaacaaaaac
    11881 ttaccgctgt catggctgtg gtaataactg tctaatcaca acacaaattt ttcctgatgg
    11941 caatcgctat tctacaggaa atcgctgtga aaaaggcatt ggtaaacaaa tagctaaaga
    12001 agataaagca cctaatattt ataaatataa atatcatcgc ttatttgaat actataaacc
    12061 acttctcaat gcaccaaaag gacgtatagg tattccacgt gtactcaata tgtatgaaga
    12121 ttttccattc tggtttactt tcttcacttt attaggttat gaagtagtat tatctggcaa
    12181 atcttcagct cagttatatt gtaaaggcat gtctactatt ccttctgact ctttatgtta
    12241 tccaggaaaa ttagtacacg gtcatatcat ggatttaatt gaaaaaggta tcactactat
    12301 cttttatcca tgtatccctt ataatatgaa agaccctctt catgcctccg ataacaatta
    12361 taactgtcct attgtcgctt cttatgctga aaatatccgc gctaatatgg atattctccg
    12421 ccagaaaaat ataaacttcc ttcaaccatt cttaccaata aataataaaa aagctttgat
    12481 taaacgttta caagaagaat tatcttcttt aaatattcct aaaaaagact taatcgaagc
    12541 tgtagaaaaa agttatcaag aattagataa atataaagaa gacattcgca actatggtga
    12601 aaatatcatc aaagaagcaa ctgataaaaa aatgccaatt gtcgttttag ctggtagacc
    12661 ataccatgtt gatcctgaaa tcaatcatgg tattcctgaa atgattcaat cttacggtat
    12721 tgcaatttta tctgaagatg ctctttatca tttagattgc ccagaagata gcttagatat
    12781 cgtaaaccaa tggagctatc atgctagatt gtatcatgct gctagttacg tagctcgcca
    12841 caaagaaatg actttaattc aattcagttc ctttggttgt ggtcttgatg ctatcactac
    12901 tggtcaagta cgtgaaatct tagaacaaca tggcgatatc tacactatga taaaattaga
    12961 tgaagtaagt aaccttggtg cagctcgtat acgtattcgt tctctcatgg ctgcatggaa
    13021 atatggcttt gcccaaattg acgaaattga accgccaaaa caacgtgctt atttcagcaa
    13081 agaatgtcaa gaagaacata ctatcttggc accgcaaatg tctcctaaac attttgattt
    13141 cattcaacat gcttgtaaaa aatctggtat gaaaatcgtc attccgccaa tgcctacaca
    13201 agaagatatt gacttaggtc tacgctatgt caataatgat atgtgctatc ctgcaatcgt
    13261 agtcattggt caattattaa aagcattaaa atcaggcgaa tatgatgtaa ataatacttc
    13321 aatcatgctt ttccaaacat gtggtgcttg ccgtgctaca aactatttaa atttaatgcg
    13381 taaagcttta gaaaatgccg gcttaagcca agttcctgta tttgcttgtg ttggtcgtga
    13441 aacagatgat ttcaaattaa aaacagaaat ctggcttgat gttgtcaaag ctactattta
    13501 ctctgactta ttaattcgtc tatccaatag aacaagacct tatgaaaaag tagctggctc
    13561 tgttgatgtc ttatataata aatggcgtaa aatcttcatg gacgaaatca ctaatggcaa
    13621 ttatattaaa ttcagcaata atatcaaaaa agctgtaaaa gaatttgatg aaattgctct
    13681 caatgaagat gtaataaaac caaaagtagg tatcgttggc gaaattcttg ttaaatatca
    13741 cccaacagct aataatcatg tagaaaaaat tctctttgat gaaggtgctg aagttgtaac
    13801 acctgattta atggatttct tcatgtacat ggcatatgat gatatcgtaa aatataaaat
    13861 gcttgatggt aaatggatag ataaagctaa atcagaaatt ttcatcaaag ttcttgaatt
    13921 tttccgcaaa cctatgcgca aagcacttcg tgctagcaaa cgcttcactg ctccatatac
    13981 tattaaagaa atagctaaat taactactcc tcatgtttct ttaggtaata tggctggtga
    14041 aggttggttc ttaactggtg aaatggcaaa attgatccaa gaaggtgtag ataatatcat
    14101 ttgtttacaa ccatttggtt gcttgccaaa tcacatcaca ggaaaaggta tgatacgtga
    14161 actcatgcgt acacatgatg gtgtaaatat cgtagctatt gactgtgatg ctggtatcag
    14221 tgaagtaaac cagttaaatc gtataaaatt aatgctttct gtagctaaag aaaaaatcgc
    14281 tgagcaagac cataaagctc tataaaaaaa atgataaagt aataaaaaat aagaactgta
    14341 ttttcaaaga tacggttctt atttttttgc attgacttga attgacatac tccccatgcc
    14401 taaatgcagg ggattcttgg atacaaacga tacttgccta ctaaaatagc aggtcttact
    14461 atatctctcc aaagaaggtt gatgccccaa ccttccatat atttatagca gcatttctat
    14521 ctctatcgtg gctggttttg cactttgcgc aaatccactc acgaactgcc aaatttttag
    14581 tttcaggatt ttttgtacca caaacatggc aaatttgcga acttggatag tatctatcta
    14641 tcttttgcac tattga
//
