LOCUS       c00011_NZ_JAGZ..       14926 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_JAGZDX010000005.1 MAG: Ruminococcus sp. isolate
            L3_082_000M1_dasL3_082_000M1_metabat.metabat.88
            L3_082_000M1_scaffold_72, whole genome shotgun sequence.
ACCESSION   c00011_NZ_JAGZ..
VERSION     c00011_NZ_JAGZ..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 00:58:11
            Original ID  :: NZ_JAGZDX010000005.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 129234
            Orig. end    :: 144160
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14926
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[139234:142462]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13228
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14926
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14926
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(531..2270)
                     /locus_tag="ctg11_122"
                     /transl_table=11
                     /translation="MALDGIFLRHIKSEIEKEALGARVSQIYQPNREELVFGLRTFSGN
                     KKLLLSARANSPRVNFCSSTPENPAQPPMFCMLLRKRIGGGKLVGLRQNGCDRVLMLDF
                     ECVNELGDTVMITVVCEIMGMYSNIIIVDSNGVIIDSLKRVDLTMSSKRLVLPNIKYEL
                     PESQNKLNLLKCSVLDVCTAVKNLDTEMPLNKALLRTIEGVSPIVCREIEYKVMEGTTN
                     RIEGVLFDRLAVEIEKLKSVCSDCSGKPVVVYREDGKPMDLCFMNVEQYGDFAKVESKE
                     SFSDLLDGFYEARDSRDRMRVKSQSLTKLLNNTLERLARKIAKQKSELERCADREHLRI
                     CGDLLQANIYRIERGAEYVDVENFYDENNAILRIKLNPAISPSANAQKYYKDYRKAKNA
                     EIMLKEQLEKGREELDYINSVLDTVDRAENEKDLAQIREELTEQGYLKVQKGKKPRQTT
                     LPPLEFESSDGFKILVGRNNRQNDKLTLKTASKNDMWLHTKNIHGSHVIVVSDGKEISN
                     TAIYEAARLAAYHSKARNSSQVPVDCTLVRYVSKPNGSKPGMVIYVNNKTLYVKPSQTV
                     EKQ"
     CDS             complement(2285..2770)
                     /locus_tag="ctg11_123"
                     /transl_table=11
                     /translation="MIKINIICIGKIKEKYFTDAIAEYAKRLTAFCKFNIIELSEERIK
                     SNIPNRSQIDEVIFSEGKRIMQKISPSDYVVAMCIEGKSMSSEELSRLIDNASVSGKST
                     VDFIIGGSYGLDESVKKRADVRLSMSRMTFPHQMARMILSEQIYRAFEISSNGKYHK"
     CDS             complement(2792..3580)
                     /locus_tag="ctg11_124"
                     /transl_table=11
                     /translation="LARAVPLFSGSKGNSYYIGSASEGVLIDAGRSCKQIENAMLANGL
                     DMGSIGAVFITHEHTDHCSALRVLAKRYGFKVYSSLGTLNALRAGNKLDPNTDADVITD
                     EVVIGNMRVQRIDTPHDAAESCCYRVTAPDGKSALIATDMGVMLPDVRTAAEQSDFVVL
                     ESNHDINMLKNGFYPYPLKQRILSNRGHLSNEACAKELVNLVEKGTLRLMLGHLSEENN
                     TVPLAMSTSVDLLTSNGMKYKSDYSLDVAPSVSTTKAIIF"
     CDS             complement(3703..4995)
                     /locus_tag="ctg11_125"
                     /transl_table=11
                     /translation="LEKFVVTGGKPLSGEVTISGAKNAAVAIIPAVILCDEPCQIENIP
                     NISDVSLISRILQQMGANVRRINRSSLYIDPTKIRTCNAVTDLVRGMRASYYLLGALLG
                     KYGKAKVALPGGCNFGVRPIDQHLKGFEALGATTQLVDGAIIEAECDSLVGTHVYLDVV
                     SVGATMNIMLAASKAKGQTIIENAAREPHIVDLANFLNSMGADVRGAGTDVIKIRGVEY
                     LHGITYSIIPDQIEAGTYMCAAAATRGCITVKNITPKHLESISAKLREMGVKITEYDEA
                     LKVDASSAPLKRCNIKTMPHPGFPTDCQPQFAALLMSVPGTSIINENVWDNRYQYVSEL
                     IRMGAQISVEGRLAIIEGGVPLTAAPVKATDLRAGAAMIIAALEINGTTEISNIQFIER
                     GYEDVVEKFRGLGADIKKVYFTGDNEQELGA"
     CDS             5717..6034
                     /locus_tag="ctg11_126"
                     /transl_table=11
                     /translation="MENKEKTTTPEMPDIDVLFELADLFKVFGDSTRLRIMYTISENEM
                     SVLNIAEALSMEQSTISHQLRVLRQNKLVRVRREGKQIYYSLDDDHVKRIIEMGLDHVL
                     E"
     CDS             6047..8371
                     /locus_tag="ctg11_127"
                     /transl_table=11
                     /translation="MRYKYQLDNLNCAHCAGKIEAKIAETNGFEDVSFNFATKLLNFKS
                     EKQNPVSEIQAICDSIEDGVTVVDKTPKTNLKKYTYTLDNLNCAHCAGKIEAKIAETDG
                     FEDVSFNFATKLLNFKSEKQNPVSEIQAICDSIEDGVTVVDKTPKNDITTKAEPEITKK
                     KINHDTIFLAISIVLAVVSEILHLTLDGVTAVHYVVLAACFVATLLSGYKVFIKGAKNI
                     LKLRIDETTLMAVAVIAAFCLGDFVEAAMVTILFSIGEIFEDRAVDASRRDIEKLANIR
                     PDTATIIVDGAEQIVPAESVEIGSIIEVKPYERVPLDGIIIKGKTTLDTSALTGESLPV
                     DADEGSEVLSGAINGSNLITVKTTKHFGDSTATRILQLVEDAAAQKGNSEKLISRFASV
                     YTPVVVLIAVAIAVIPPLCGLGAFSEWLYRALVCLVASCPCAIVISVPLSYYSGIGAAS
                     EVGVLIKGGKYIEALAKADTFVFDKTGTLTSGKLSVNKVNTVGSYSADEVLALAAASEK
                     YSAHPIASAIREKAIGLELPELSDYSESAGHGTSAVYNGKTIQCGGSKILSDEQKKIAN
                     KDDSVFVIYDGQLIGSLNVSDTVRPEAKEVISQLKALGVKNTVMLTGDRQQPAENVKNE
                     LRLSECHAELLPAQKLELFKGLKSKSKGACFVGDGINDAPVLSASDCGIAMGFGSEAAI
                     EASDAVLASGTLKQLPKAIKIARSVINTVKGNIIFALSIKALVIILAAFGLAQIWMSVI
                     ADTGVSVVCVLIAARLLKKKY"
     CDS             8569..9804
                     /locus_tag="ctg11_128"
                     /transl_table=11
                     /translation="LKKIFLLLVTTLFLLSLYGCNTSSSSNNSTEQTTVTNTDDLSLDT
                     DTDSETEFNYDLEIYNNDKKIDTLNLFDAFMPTEDGLIYSKINETSPNEIEYYRYYLDK
                     KSSIKLGSIKDWTMQINDKAYVNNHLCFMASTGDITDEENRTLEFIDIDLNKNKMTTVF
                     SDKGGFPYDTVTGADNLVIITKVLNNGTSLELYDTETQKFKQLKYLEFDDKNCVGKTIR
                     KVSIDDKTKTICLLVLDCVSETDVSLRIETYDYDMNFLKSYDISNISDDSNELIQGVQF
                     FDFRNNYLIYQNFSMTRCIGYIGNKKLQKSDMIDNIDDTYSMAQTPQKGYNTVLSFKDV
                     DLERNIYLFNTIDKTMKKTKFKPEEENYYIGSMLRTGKDNLMIITTPDNTDGKSNLNPK
                     LYFTKLSDLNFQ"
     CDS             10001..11623
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_129"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.9e-42, bitscore:
                     137.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISGAEIMVKCLEAEGVDIVFGYPGAAICPFYDKVYDSSITHILV
                     RQEQNAAHAASGYARCSNRPGVCVATSGPGATNLITGIATAYTDSIPIVAITGQVRSDL
                     LGRDVFQEADITGACEPFVKHSYLVSKTEDLPRVFKEAFHIASTGRPGPVLIDIPVDIQ
                     ENEIESFEYPESVNIIGYKPNTKGHAIQVKKAVEAINASKRPVIVSGGGVLSSGIKLKL
                     QKFAETTGIPVISTMMGIGVMPSEHELYLGMLGTHGKAVANRALHEADLVIVCGARLGD
                     RAVAAPDQMSENTKVIHIDIDPAEIGKNVKTEIPIVGDMKNVINMLLDSIGDYKVTTMW
                     SETVKNWKKDLYREPPVFDGFVEPRTLVGHLSAMFRSKAILVADVGQNQIWCANNFRIR
                     EGRFLTTGGMGTMGYSIPAAIGAKFARPDRDVIVICGDGSFQMGLNELATIAGNQLGIK
                     IIIMKNARLGMVRELQDKHYGGRHSATILNGDPDFLKIADAYGIDHAEAHSNKEAENII
                     KGIVDSEKPFILVCDVHPDTPSI"
     CDS             11636..12127
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_130"
                     /sec_met_domain="ALS_ss_C (E-value: 1.8e-29, bitscore:
                     94.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQYTLSILVENQAGVLSKISGLFSRRGFNIDSLAVGVTQEPSVSR
                     ITIVANGDEYIVEQLEKQLNKLIPVIKVKRLNEGEFISRELVLIKVHCAASKRAEIVKT
                     VEIMQAKIVDVSPSSVTVEYCECASRINTLVDLLKPYGIREIVRTGTVAIDRGTASVSV
                     "
     CDS             12188..13228
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_131"
                     /sec_met_domain="IlvN (E-value: 8.1e-83, bitscore: 269.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 5.7e-60, bitscore: 194.9,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYTKNMTAPIYYQSDCNLDLLKGKKIAIIGYGSQGHAHALNLK
                     DSGCDVIIGLYKGSKSWAKAEAQGFKVYTSAEAAKQADIIMILINDEKQAALYKNDIEP
                     NLEAGNMLMFAHGFNIHFGCIKPPKDVDVTMVAPKGPGHTVRSEYQVGKGVPCLVAVEQ
                     DATGQAKDLALAYALGIGGARAGVLETTFRTETETDLFGEQAVLCGGVCALMQAGFETL
                     CDAGYDPRNAYFECIHEMKLIVDLIYQSGFAGMRYSISNTAEYGDYITGPKIITEDTKK
                     AMRKVLSDIQDGTFAKDFLLDMSDAGSQVHFKAMRKIAAEAPAEVFGKEVRKLYSWSDE
                     DKLINN"
     CDS             complement(13416..14924)
                     /locus_tag="ctg11_132"
                     /transl_table=11
                     /translation="CISADGKSFTSGYDSKGTTVKYIAAPEISKLESVNGGVKISWGKV
                     NGATKYRVYYKGSKGWTKMVDTTSTSYIDKDVSSGRNYTYTVRCITSDAKKFTSGYNPT
                     GKSVKYVATPKISKLEVTYDGVKLTWNKVAGAEKYRVYYKDRNGWTKLADTTGTTMLDM
                     NVVSKEFDLSIDDIYYTVRCISKDAKSFTSGYDSKGTPIGNHQDCPEIYSIGAVNNGVE
                     MHWTGDAPKFRVYIKENGSWKRIAETYDNYYVHKGAKSGSNTYTVRGVSKDGKKFTTMF
                     NPTGVTYRYKTSDKTRDAYINYMMNHTDEWMPSLGSNHTLSGVMFLDFDFDGVPELVAQ
                     KADSEEYGFHSVVYKFEDGKLKRVGNVNDGFSIYYNKTAKKYEVHDLDIYLNVDDGYYW
                     SGNSIITYDGENLFANMYSSRGVSEESNNNIYYSYFDGNDKNISRAKYNEINLKQFNNC
                     VNAHMFTEFIATGYGDTSVWGEKTTAENKQSLLDAYNSFSYEKY"
ORIGIN
        1 aaacgcagat tcggcgatca ggttttgtta agtcttatgt gtcagtacat tcctatgggc
       61 aaggtcagcg acagggagtt ttcacgaatt aaccgtaaaa tcacacgcag agaatatgac
      121 aaggtaaagc ttgaaatgat gcgactggga attgacggct ttacacagga gctttcttcc
      181 gcagatgaaa gctatgtccc cgaatgggat tttgaaggat gattttgtca gttcggtcat
      241 ctgaattcct cttcattttt caattggtat tgtttacttg gtattattct cttagtcttt
      301 ttctatgggt attattaggc ttcaaattct gaagtagtcc ccttcaaaat ctgaaggggg
      361 cgggttcaaa ttctgaaggg ggcaggtgca aattctgaag ggtatgagtt caaattctgc
      421 acccctaaaa tacgaatttt tacattcgat tttaccgccc gttaaaaaca attaaattaa
      481 cataaaaacg gagagcgtct tgccctccgt ttaattttta ttaaaatatt ttactgcttt
      541 tcaaccgttt gtgacggttt tacatacagg gttttgttgt tgacataaat caccataccc
      601 ggttttgagc cgtttggctt tgacacatag cgaacaagtg tgcagtcaac gggaacctga
      661 ctgctgtttc tcgccttact gtgatatgcc gcaagccgtg ccgcctcata gattgccgtg
      721 ttggaaatct ctttgccgtc cgaaacaaca attacatgag aaccgtgaat attctttgtg
      781 tgcagccaca tatcgttctt tgacgctgtt ttcaaagtca gcttatcatt ctggcggttg
      841 tttcttccta caaggatttt aaaaccgtcg cttgattcaa attcgagcgg tggcaaagtt
      901 gtctgacggg gctttttgcc cttttgaacc ttgagatagc cctgctcggt aagttcctca
      961 cgaatttgtg caaggtcttt ttcattttcc gcacggtcaa ccgtatcgag aaccgagtta
     1021 atataatcaa gctcttccct gcccttttca agctgttctt tgagcataat ttcggcattt
     1081 ttagccttgc ggtaatcctt gtaatacttc tgagcatttg ccgaaggtga gattgccgga
     1141 ttaagcttta tgcgtaaaat tgcgttgttc tcatcgtaaa agttttcaac atcaacatac
     1201 tccgcaccac gctcaatacg atagatattt gcctgtaaaa ggtcaccgca tatgcgaaga
     1261 tgctcacggt ctgcacagcg ttcaagctca ctcttctgct ttgcaatttt tcgggcaagc
     1321 ctttcaagtg tgttgttcaa aagctttgta aggctttgtg atttcaccct cattctgtca
     1381 cgactgtcac gagcctcata gaatccgtca agcaaatcgg agaagctttc cttactctca
     1441 acctttgcaa aatcgccgta ctgctcaaca ttcataaagc agaggtccat aggcttgccg
     1501 tcctcacgat aaaccacaac aggcttgccc gaacaatcgc tgcaaacgct tttcagcttt
     1561 tcaatttcaa ctgcgagtcg gtcaaaaagc acaccctcaa ttctgtttgt tgtgccctcc
     1621 ataaccttgt attcaatctc acggcataca atcggagaaa cgccctcaat tgtccttaac
     1681 agcgccttgt taagcggcat ttccgtgtca agatttttta cggctgtaca cacatcaagc
     1741 accgaacatt taaggagatt cagcttgttc tgcgattcgg gaagttcgta ttttatattc
     1801 ggcagtacaa gtcttttact gctcattgta agatctacac gctttaatga atcaatgatg
     1861 acgccgtttg aatcgacaat aattatgttg ctgtacatac ccataatttc gcatacaaca
     1921 gttatcatca cagtatcgcc gagttcgttc acgcactcga aatcgagcat aagaacacgg
     1981 tcgcaaccgt tctggcgaag tcccacaagc tttccgccgc cgattctttt tcgcaaaagc
     2041 atacagaaca tcggaggttg tgcaggattt tcgggtgttg aggaacaaaa gttcactctc
     2101 ggtgaatttg ctcgtgcaga aagcaacagc tttttgttgc cggaaaatgt tctcaaccca
     2161 aacacaagct cctctctgtt cggctgataa atctgcgaca cccttgcacc gagagcctct
     2221 ttttctattt cacttttaat atgtcttaaa aaaattccgt caagcgccat agtaactccg
     2281 taaattattt gtgatattta ccgtttgatg aaatctcaaa cgcacggtaa atctgttcgc
     2341 ttaaaatcat tcttgccatt tggtgaggaa aggtcattct gctcattgaa agacggacat
     2401 ctgcccgttt tttaaccgat tcgtcaagtc cgtagctgcc gccgataata aaatcaacgg
     2461 tgctttttcc gcttacggac gcattgtcaa tcagccttga aagctcctca ctcgacatag
     2521 actttccctc aatacacatt gcaacaacat aatccgaagg cgaaattttt tgcatgattc
     2581 gttttccctc agagaaaatg acctcatcaa tctgcgacct attcggtatg ttgctcttaa
     2641 tgcgttcttc cgaaagctca ataatattga atttacaaaa tgcggtcaag cgttttgcat
     2701 actctgcaat tgcgtcggta aaatattttt ccttgatttt gccgatacaa attatgttaa
     2761 tcttaatcat atttctcttg tttgtttaag gttaaaagat gatggctttt gttgtgctta
     2821 cactcggagc aacatcaagc gaataatcgc ttttgtactt cattccgttt gatgtgagca
     2881 ggtctacgga tgttgacatt gcaagcggaa cggtattatt ttcttcgctg agatggccga
     2941 gcataagtct taaagttccc ttctcaacaa ggttaacaag ttcttttgca caagcctcat
     3001 ttgaaagatg tcctctgttt gaaaggattc tctgcttgag cggataagga taaaatccgt
     3061 ttttgagcat attgatatcg tgatttgact caagcacaac aaagtcgctc tgctctgcgg
     3121 cagttctgac atcgggcaac ataacgccca tatcggttgc tataagtgcg gattttccat
     3181 cgggagcagt aacacggtaa caacagcttt ccgccgcatc gtggggggtg tcaattcgct
     3241 gaacacgcat attgccgatt acaacctcgt cagttataac atctgcatct gtgtttggat
     3301 caagcttatt acctgccctc aaagcattga gcgtaccaag acttgaatac accttaaagc
     3361 cgtaacgctt tgcaagcaca cgcaacgcac tgcaatggtc agtgtgttcg tgagttataa
     3421 aaaccgcccc gatactgccc atatcaagtc cgtttgcaag catggcattt tcaatctgct
     3481 tgcatgaacg acctgcgtca atcagtacgc cttcgcttgc cgaacctatg tagtagctgt
     3541 tacccttact tccgctgaac agcggtactg ctcttgccaa aacaatcaat ccttatcttt
     3601 agtataacga atatgataac acaaatttta aaatttgtaa attatctcac aaaaaagccg
     3661 ttctcacaaa gaaaacggct ttgatttcta attaaatttt agttaggcac cgagctcctg
     3721 ctcgttgtca cctgtaaaat acaccttttt gatatctgca ccaagtcctc tgaacttttc
     3781 aacaacatct tcatatccac gctcaatgaa ctgaatatta gaaatctctg ttgtaccgtt
     3841 aatttcaaga gcggcaataa tcatagccgc acctgcacga aggtcggttg ccttaacggg
     3901 agccgctgtg agcggaacac cgccttcaat gattgcaagt ctgccctcaa cagaaatctg
     3961 cgcacccatt ctgataagct cgctgacata ctgatagcga ttatcccaaa cattctcgtt
     4021 gatgatgctt gttccgggaa cgctcataag caatgcagca aactgcggct gacagtctgt
     4081 cgggaagccg ggatgcggca ttgtcttgat attacagcgc tttagcggag cagatgacgc
     4141 atcaaccttg agagcctcat catattccgt aatcttaaca cccatctcac gcagctttgc
     4201 gctgattgat tcaagatgct tcggtgtaat attctttacc gtaatacaac ctcttgttgc
     4261 ggcggcggca cacatatatg ttcctgcctc aatctggtcg ggaataatcg aataagtaat
     4321 gccgtgaaga tactcaacgc cacggatttt gataacatcc gtacctgcgc ctctgacatc
     4381 cgcacccatt gaattaagga agtttgcaag gtcaacaata tgcggttctc ttgcggcatt
     4441 ttcaataatg gtctgtccct ttgcctttga tgcggcaagc ataatgttca ttgttgcacc
     4501 aacggacaca acatcaaggt acacatgtgt accgacaagg ctgtcgcatt ctgcctctat
     4561 aatcgcaccg tcaacaagct gagttgtcgc accgagagcc tcaaagcctt taagatgctg
     4621 gtcaatcgga cgcacgccaa agttacagcc gcccggaaga gccaccttag ccttgccgta
     4681 cttgcccaaa agtgcgccga ggagataata tgacgctctc atacctctta caaggtcggt
     4741 cacagcatta catgtgcgga tttttgtagg atcaatatat aaggacgaac ggttgattcg
     4801 tcttacatta gcacccatct gctgaagaat tctgctgata agtgatacat cgctgatgtt
     4861 aggaatattt tcaatctggc acggttcatc acaaagaata actgccggaa taattgcaac
     4921 ggctgcattt ttcgcaccgc tgattgtcac ttcacccgat aatggctttc cgccggtaac
     4981 tacgaacttc tccaattgtt acaccccaat taatgtgtag aagatacttt taactaaata
     5041 agctaaatat ctgaaaatgt atatctatat agtgtataag taaaaatcaa aaattatacg
     5101 aatctaaaat tcataatgag aactaatttg ttacatttta ttaaaaacga acccactcgg
     5161 ttacgcagat gtaatttaac aattctctta cagaaaatga tactacaaaa ttgtagtaaa
     5221 gtcaacggaa taataaaact gtaatctatt tttgggcaag ttgtactcaa attattaatt
     5281 tgttgctttt tttgttttta atataaccaa ccatgctttt taaaaccgtt ttttcctaaa
     5341 aagaagtaat taatcaaagc gattttttgt aaaattatta caaattgaaa caagtgttat
     5401 ttcatcagac atctgagcat tttacaattc aaattgaaca cagaaaaata tcgttccgtt
     5461 attcctatga taattttaca ccttcaatct tcttttttca aatttaaaat taactttcta
     5521 tactatatat actttccaaa cggacacaat aaacaagtga aactttgggg caaaaaaact
     5581 tgaaaaacat tacatttttt cgtgtgtgtc tattgacttt ttaaaaagtg aatgctatat
     5641 tataattaac atatgagcat atcttcatat gttcaagtat aactattaac ctgagataaa
     5701 attaaagggg acgcctatgg aaaacaaaga aaaaacaact actcccgaaa tgcccgacat
     5761 tgatgtgctg tttgagcttg cagacctttt taaggttttc ggtgattcaa cccgacttcg
     5821 cattatgtac accatttcgg aaaatgaaat gtcggtgctc aacattgctg aagctctcag
     5881 catggagcaa agcacaattt cccatcaact gcgtgtgtta aggcagaaca agctggtgcg
     5941 tgttcgccgt gaaggaaagc agatttatta cagccttgac gatgaccatg tgaaacgaat
     6001 catagaaatg ggacttgacc atgttcttga ataaggaggg agacatatga ggtacaaata
     6061 tcagcttgac aatctcaact gcgctcattg tgcaggcaag attgaggcta aaattgcaga
     6121 aacaaacggc tttgaggatg tgagtttcaa ttttgcgaca aaacttctca atttcaaaag
     6181 cgaaaagcag aatcctgttt ccgaaattca ggcaatctgc gacagcattg aggacggtgt
     6241 aaccgttgtt gacaaaactc cgaaaaccaa tctcaaaaaa tacacctaca ctttagacaa
     6301 tctcaactgc gctcattgtg caggcaagat tgaggctaaa attgcagaaa cagacggctt
     6361 tgaggatgta agctttaatt ttgcgacaaa acttctcaat ttcaaaagcg aaaagcagaa
     6421 tcctgtttcc gaaattcagg caatctgcga cagcattgag gacggtgtaa ctgttgttga
     6481 caaaactccg aaaaatgata tcacaacaaa ggcagaaccc gaaatcacaa aaaagaaaat
     6541 caaccatgac acaatcttcc tcgcaatttc aattgtactt gctgtagtgt ccgaaattct
     6601 ccaccttaca cttgacggtg ttacggctgt tcattatgtt gtactcgcag cgtgttttgt
     6661 tgcaacactt ctttcgggtt acaaggtatt tatcaagggt gcaaaaaaca ttctaaagct
     6721 aagaattgac gaaacaacgc ttatggctgt tgcggtaatt gcggcattct gtcttggaga
     6781 ttttgttgag gcggcaatgg taacaatcct cttttctatc ggtgaaattt ttgaagatcg
     6841 agcagttgac gcatcccgcc gtgacattga aaagcttgca aacattcgtc ccgatacagc
     6901 aacaattatt gttgacggtg cggaacagat tgttcctgcc gaaagcgttg aaatcggaag
     6961 tatcattgaa gtcaagccat acgaaagagt tccgcttgac ggcattatta ttaaaggtaa
     7021 aacgactctc gacacatctg ctctcacagg cgaaagcctt cctgttgatg cagacgaggg
     7081 cagtgaggta ctcagcggcg caatcaacgg cagtaacctt attaccgtca aaaccacaaa
     7141 gcatttcggc gacagtaccg caacaagaat tcttcagctt gttgaagatg ccgccgctca
     7201 aaagggcaac agcgaaaagc ttatttcaag atttgcctct gtttacacac cggttgttgt
     7261 actcattgca gttgcaatcg cagtaatccc tccgctttgc ggactcggag cattcagcga
     7321 atggctatac cgtgcacttg tttgtcttgt agcgtcatgt ccgtgtgcta ttgttatttc
     7381 cgtacctctc tcctactatt ccggtatcgg tgcggcatcc gaagtcggtg tactcatcaa
     7441 gggtggaaaa tatattgagg ctcttgcaaa agcagacaca ttcgtattcg ataaaacagg
     7501 cacgctcaca agcggcaagc tcagcgtaaa caaggttaat acggtcggtt catacagtgc
     7561 tgacgaagtt cttgcccttg ccgctgcaag cgaaaaatat tctgctcatc cgattgcctc
     7621 cgcaatcaga gaaaaggcaa tcggtcttga actccccgag ctttccgact acagcgaaag
     7681 tgccggtcac ggaacaagcg cagtttataa cggcaaaact attcagtgcg gcggttcaaa
     7741 gattctttcg gacgaacaga agaagattgc aaataaagac gattctgttt tcgtaattta
     7801 tgacggtcag cttatcggtt cgctcaatgt cagcgacaca gtaagacctg aggcaaaaga
     7861 ggttatctca cagcttaaag cgctcggtgt caagaacacg gtaatgctca caggcgacag
     7921 acaacagcct gccgaaaatg ttaaaaacga actcagactt tccgaatgtc acgcagagct
     7981 tctccctgct caaaagcttg aacttttcaa gggcttgaaa tcaaaatcca agggtgcttg
     8041 ctttgtaggc gacggcatca atgatgcccc tgttctttcg gcaagcgact gcggtatcgc
     8101 aatgggattc ggcagtgaag ccgctattga agcgtcagac gcagttctcg catcaggcac
     8161 actcaaacag cttccaaagg caattaaaat tgcaagaagt gttatcaaca ccgtcaaagg
     8221 caacatcatc tttgccctct caatcaaggc tcttgtaatt atccttgccg cattcggtct
     8281 tgcacaaatc tggatgtccg ttatcgccga cacaggcgtc agcgtagtct gcgtcctcat
     8341 agccgcaaga ctcctcaaaa agaaatattg attttttgca aatcatatca tttattatga
     8401 taaagcaccg tgagctttca caagtttcac ggtgctttca tttgccaaaa tttttctaaa
     8461 cataatctta tattatagta ttttaaaatc attgactttt ataattatgt aaattataat
     8521 atttttgtca gtgcttgcaa ctgataaata aacttcggag agattaattt gaaaaagata
     8581 tttttattat tagtaaccac tttattttta ctttcattat atggatgtaa cacttcttca
     8641 tcaagcaata attccactga acaaacaacc gtaacgaata cagatgattt atctcttgat
     8701 acagatacag attctgaaac agaatttaat tacgatttgg agatttacaa caacgataaa
     8761 aaaatagata ccttaaatct tttcgatgca tttatgccaa ctgaggatgg actcatatat
     8821 tcaaaaatca acgaaacttc tccgaatgaa atagaatact acagatacta tttagacaaa
     8881 aagagcagta taaaactcgg ctcaataaaa gactggacaa tgcaaattaa cgataaagcg
     8941 tatgtaaata atcacttatg ttttatggca agcacgggtg acattacaga tgaagaaaac
     9001 agaacccttg aatttattga tatagacctt aataaaaaca aaatgactac tgtcttttct
     9061 gacaaaggcg gttttcccta tgataccgtt acaggtgcag acaatcttgt cataattaca
     9121 aaagtattaa acaacggtac ttctttggaa ctgtatgaca ccgaaacgca aaagttcaaa
     9181 caactgaaat atttagagtt tgatgataag aactgtgtag gaaaaactat aagaaaagtt
     9241 tcaattgacg acaaaacaaa aacaatctgc ctcttggttt tggactgtgt ttcggaaaca
     9301 gatgtttctt taagaataga aacctatgac tatgatatga attttcttaa aagctacgat
     9361 atctccaata tttcggatga ttctaacgaa ttgattcaag gagtgcagtt ttttgatttc
     9421 agaaacaact accttatcta tcaaaatttt agtatgacaa gatgtatagg ttatataggg
     9481 aacaaaaaat tgcaaaaatc cgatatgatt gacaacattg acgacaccta ctctatggct
     9541 caaactccac aaaaaggata taatacagtt ttatcattta aagatgttga tttagaacgc
     9601 aatatatact tatttaatac cattgacaaa acaatgaaaa aaacaaaatt caaacctgaa
     9661 gaagaaaact actatatcgg ctcaatgtta agaactggaa aagataattt gatgataata
     9721 acaactcctg ataatacaga cgggaaaagt aatcttaatc caaaactata ctttacaaaa
     9781 ttaagcgact taaattttca gtaaacaggc ggtaaaaatc aattaaaatc cattttgcaa
     9841 attatctgtc aaaatcctgc aaaaaattta atttatgggc aatactgctc tttacttttt
     9901 aaggtattta ttgtataatt agcggtaaag caaaaaggtt tattttatgt tacaaaacac
     9961 cttttgctca caataaaaag gataggaggg acaaaacata atgatcagcg gtgctgaaat
    10021 tatggtaaaa tgtttggaag ccgagggcgt tgacatagtc tttggttatc ccggtgcggc
    10081 tatttgccca ttttacgata aagtttacga ttcgagcatt acccacattc ttgttcgtca
    10141 ggaacagaac gctgctcatg cggcaagcgg ctatgcaaga tgcagtaatc gtcccggtgt
    10201 ttgcgtggca acttccggtc ccggtgcaac caaccttatc acaggcattg cgaccgccta
    10261 tacggactct attccgattg ttgccattac aggtcaggtt cgttccgacc ttctcggcag
    10321 agatgtcttt caggaagctg acatcacagg agcttgtgaa ccgtttgtaa agcacagtta
    10381 tctcgtcagc aaaacagaag accttccgag agttttcaaa gaggctttcc atattgcctc
    10441 aaccggcaga cccggtcctg tacttatcga cattcccgtt gatattcagg aaaatgaaat
    10501 tgaaagtttt gaatatcccg aaagcgtaaa cattatcggt tacaagccga acactaaggg
    10561 acacgcaatt caggttaaaa aggctgttga ggccatcaac gcaagcaagc gtcctgttat
    10621 cgtatcaggc ggcggcgtgc tgagttcggg tatcaagctt aaacttcaaa aatttgcaga
    10681 aactacgggt atccccgtta tttcaactat gatgggcatc ggtgttatgc ccagcgagca
    10741 tgagctttat ctcggaatgc tcggcactca cggcaaggct gttgccaacc gtgctcttca
    10801 cgaagccgac cttgtaatcg tatgcggtgc aagactcggt gacagagctg ttgcggctcc
    10861 cgaccagatg agtgaaaaca caaaggtaat tcacattgac attgaccctg ctgaaatcgg
    10921 taagaatgtt aaaacagaaa ttccgattgt aggcgatatg aaaaatgtca tcaatatgct
    10981 gcttgacagc atcggcgatt acaaggttac aacaatgtgg agcgaaaccg taaagaactg
    11041 gaaaaaagac ctttaccgtg agcctcccgt atttgacggc tttgttgagc cgagaacact
    11101 tgtcggtcat ctcagtgcaa tgttccgctc aaaggcaatt ctcgttgccg atgtaggaca
    11161 aaatcaaatc tggtgtgcaa acaacttccg tattcgtgag ggcagattcc tcacaacagg
    11221 cggtatgggt acaatgggtt actcaattcc cgctgcaatc ggtgcaaagt ttgcaagacc
    11281 cgaccgtgat gttattgtaa tctgcggtga cggcagtttt cagatggggc ttaatgagct
    11341 tgcgactatt gcaggcaatc agctcggaat taaaatcatc attatgaaaa acgcacgact
    11401 cggaatggtt cgtgaacttc aggacaaaca ctacggcggc agacactccg caacaattct
    11461 caacggtgat cccgacttct tgaagattgc cgatgcttac ggcattgacc atgcagaggc
    11521 tcattcaaac aaggaagccg aaaacatcat caagggtatt gttgattcgg aaaaaccgtt
    11581 cattcttgtt tgcgatgttc accccgacac tccgtcaatt taatgaggtg ataaaatgca
    11641 gtatacatta tcaatacttg ttgaaaatca ggcgggcgtt ctttcaaaaa tttcgggact
    11701 tttctctcgc cgaggtttta acatcgactc acttgcagta ggtgttactc aggaaccgtc
    11761 ggtttcccga atcacaatcg ttgcaaacgg tgacgagtac attgttgaac agcttgaaaa
    11821 acagctcaac aagctcattc ccgttattaa ggtaaaaagg cttaacgagg gcgaatttat
    11881 cagccgtgag cttgttttaa tcaaggttca ctgcgccgcc tcaaaaagag ccgaaattgt
    11941 caaaacggtt gaaattatgc aggcgaaaat cgttgatgta tccccttcgt cagttaccgt
    12001 tgagtactgc gaatgtgcaa gccgcatcaa cacgcttgtt gacttactca agccttatgg
    12061 tatccgtgag attgtaagaa caggtactgt tgccattgac agaggcacag cttcggtttc
    12121 cgtttaatct tacagttagc atatatttta atttatatgc cgcgtttgcg gtaaggagga
    12181 ctttaatatg aaagactaca caaaaaacat gacagcacca atctactatc agtcagattg
    12241 taaccttgac cttctcaagg gtaagaaaat tgctattatc ggttacggca gccagggtca
    12301 tgcacacgct ctcaacctca aggattcagg ttgcgatgta atcatcggtc tttacaaagg
    12361 cagcaagagc tgggcaaagg ctgaggcaca gggctttaag gtatatacat cggcagaggc
    12421 tgcaaagcag gctgacatca tcatgattct tatcaacgat gaaaagcagg cagctcttta
    12481 caagaacgac atcgagccaa acctcgaagc aggcaatatg cttatgttcg ctcacggctt
    12541 taacattcac ttcggttgca tcaagcctcc aaaggatgtt gatgttacaa tggtagctcc
    12601 taagggaccg ggtcacacag ttcgttcaga gtatcaggtt ggtaagggtg taccttgcct
    12661 cgttgctgtt gagcaggatg ctacaggtca ggctaaggat ctcgcacttg catatgcact
    12721 cggtatcggc ggtgcaagag ccggcgttct tgaaacaaca ttcagaacag aaacagaaac
    12781 agacctcttc ggtgaacagg ctgttctttg cggtggtgtt tgcgcactta tgcaggcagg
    12841 ttttgaaaca ctttgcgatg ccggttacga cccaagaaat gcttactttg agtgtatcca
    12901 tgagatgaag ctcatcgttg accttatcta tcagtcaggt tttgcaggca tgagatattc
    12961 aatctctaac acagctgagt acggtgacta catcacaggt ccaaagatca tcacagagga
    13021 tactaagaag gctatgagaa aggttctttc tgacattcag gacggtacat ttgctaagga
    13081 cttcctcctt gacatgagcg atgccggttc acaggttcac ttcaaggcta tgagaaagat
    13141 cgctgccgaa gctcctgccg aagtattcgg taaggaagtt agaaagctct acagctggtc
    13201 tgacgaagat aagctcatca acaactaatg cgagtgtctc gcacacagtt cgtgaagaca
    13261 gtttgatgta ttcaaacttc tgtcacccga gcattacata gtacgaatta acggttcagt
    13321 caatttgcct gaaccgtttt ttgttgtgca ataaaagggt tcagcttttt acggctgaac
    13381 ccttttgcag ttaaaactta ttaattttta aataatcaat acttctcata ggagaaagaa
    13441 ttataagcgt caagcaaaga ctgcttattc tcagcggtag ttttctcacc ccatacgctg
    13501 gtatcaccat aacctgtcgc aataaattcg gtaaacatat gtgcatttac gcaattatta
    13561 aactgtttaa ggttaatttc gttatatttt gcccgtgaaa tatttttgtc attaccgtca
    13621 aaataactat aataaatatt attatttgat tcttcgctta cgcctcttga cgaatacata
    13681 tttgcaaaaa gattctctcc gtcgtatgtg attattgaat tacccgacca atagtaaccg
    13741 tcatctacat ttaaatatat atccaggtcg tgaacctcat actttttggc agttttatta
    13801 tagtatatcg aaaaaccgtc gttaacattt cccactcttt ttaacttacc gtcttcaaat
    13861 ttgtaaacaa cggaatggaa accatactcc tcggaatcag ccttttgtgc aacaagttcc
    13921 ggaactccgt caaagtcgaa atccaaaaac ataacacctg acaaagtgtg attacttccc
    13981 aagcttggca tccattcatc agtgtgattc atcatataat tgatataagc gtcccttgtt
    14041 ttatcggatg tcttatatct gtatgttaca ccggttgggt taaacatcgt agtaaacttt
    14101 ttaccgtctt ttgaaacacc tcttaccgta taagtgttac tgccggactt tgcacccttg
    14161 tgaacataat agttgtcata agtttctgct atcctcttcc aagaaccgtt ttctttaata
    14221 taaacacgga actttggcgc atctcccgtc caatgcattt caacaccgtt gtttactgca
    14281 ccaatgctgt aaatttcggg acaatcctga tgattgccaa taggcgtacc ctttgaatcg
    14341 tagccgcttg taaaactctt ggcatccttg ctgatacaac gaaccgtgta ataaatatca
    14401 tcaatgctta aatcaaattc ctttgaaaca acattcatat caagcatagt cgtgcctgtt
    14461 gtatcggcaa gctttgtcca accgtttctg tccttgtagt acacacgata cttctctgca
    14521 cctgcaacct tgttccatgt cagctttacg ccgtcatatg tgacctcaag ttttgaaatt
    14581 ttcggtgtgg caacatactt taccgacttg cctgtcgggt tataaccgct tgtaaatttc
    14641 tttgcgtcgg atgtaatgca tctaaccgta taggtgtaat ttctgcccga tgaaacatcc
    14701 ttgtcgatat atgaggttga agttgtatca accatttttg tccagccttt actgcccttg
    14761 tagtaaactc tgtatttagt tgcaccgttc actttgcccc aagagatttt tacaccgccg
    14821 tttacgcttt caagctttga aatttcgggg gcagcaatat attttacggt tgtccccttt
    14881 gaatcataac cgcttgtaaa gctctttccg tcagcagaaa tacatc
//
