LOCUS       c00034_NZ_CYYA..       13725 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CYYA01000034.1 Eubacterium ramulus strain 2789STDY5608891, whole
            genome shotgun sequence.
ACCESSION   NZ_CYYA01000034
VERSION     NZ_CYYA01000034
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 00:59:48
            Original ID  :: NZ_CYYA01000034.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13725
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13725
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4074:6326]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4075..6326
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..13725
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13725
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             220..579
                     /locus_tag="ctg34_1"
                     /transl_table=11
                     /translation="MSKTSYICNCDVIHEDIVNDVKSKMQPKDDYIQLASLFKLFGDGT
                     RVQILHALEQSEMCVCDLAVLLGVTKSAISHQLKALRLANLVKFRKEAQIVYYSLADDH
                     VKEIIDKGFEHLWQK"
     CDS             639..2993
                     /locus_tag="ctg34_2"
                     /transl_table=11
                     /translation="MKRIFLLKGLDCPNCSAKIEKEVGELDGVQSSVVNLMKQTLTINV
                     TQTAADTIASQIETIVHSHEPDVEVQEETVMNVTKSYSLKGLDCPNCSAKIEKEVGELD
                     GVQSSVVNLMKQTLTINVAPVAANTIASQIETIVHSHEPDVEVSEIAQEYYIPAKKQDT
                     NTSYNNEDKKLTVRLAIGAAIYAIGMALTVFAKVPLPIELAFLIVSYVILGGDVVWQAV
                     RNISKGRVFDEHFLMSVSTIGAFVIGEYPEAVAVMLFYQVGEFFQSLAVKRSRKSISDL
                     MDIRPDSATVRRNGELITISPENISIGEIIIVKPGEKIPLDGVVLDGDSMLDTRALTGE
                     SVPRSVHKGDEALSGCMNQTGVLMIKTTKAFGESTASKIIDLVENASSRKAPTENFITT
                     FARYYTPVVVILAAILAILPPILLGGGWTEWIRRGFVFLVVSCPCALVISIPLTFFGGI
                     GAASKRGVLVKGSNYLEALNNVSIIVFDKTGTLTKGVFNVTDILPANGFSKEQVLEYAA
                     QAESFSNHPIAKSILSAYGKEIDQSVISDYKEISGYGISAMAGKKKVYAGNTKLMDSEH
                     VEYTACEKVGTKVYVAVDGQYAGCILITDEVKPDSKKAISDLKHIGVEKTVMLTGDDEK
                     IGKSVAEELQLDEYYAQLLPDQKVEKVELLDSKKRPGSKLAFVGDGINDAPVLARADVG
                     IAMGGLGSDAAIEAADVVLMTDEPSKLVDAIEVAKATKQIVMQNIVIALGIKSVFLILG
                     ALGIAGMWEAVFGDVGVTIIAVLNAMRILKK"
     CDS             3010..3528
                     /locus_tag="ctg34_3"
                     /transl_table=11
                     /translation="VKRKLILLVVTIAFLVGFGVILHSPPSMIDAVTGATPKSKNAAQA
                     SAQLEGSYVLGINMMSDGLDNENTRNKLKELALDDSETNETDLMKTDISFRLYVSETDY
                     PLVSYAKKLCDRLKQAGFSVDLKEYSNTMMLSRVVSGKYDVFLASDDFIDVTTLTQMDY
                     MIMDSEEMR"
     CDS             3539..4078
                     /locus_tag="ctg34_4"
                     /transl_table=11
                     /translation="MRKWNTILSVLMLLIFMIHGIMGSFMLNGVGSSAGKLLAWIGVGF
                     LVVHTVIGVILTVQSLQTAKQSGKMYLKQNAIFWARRASGLAILILLFFHIGLFGKVQN
                     GTYILFPFTTVKMVTQLLFVAAIFVHIFINIRPLLVSLGIISYKERRGDIYLILSVLLL
                     FIAGAVIFYYIGWQYL"
     CDS             4075..5619
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 266.5; E-value:
                     1.5e-81)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg34_5"
                     /sec_met_domain="FAD_binding_2 (E-value: 3.4e-82, bitscore:
                     266.5, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 3e-17, bitscore:
                     52.7, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTIIIIGAGLAGLSAALQAAENGCNVKLVSSFPSERAQSVMAE
                     GGINAALNTKDENDSPEEHFTDTIKAACGLADPNAVWGMTQAAPELVHWLLKLGVQFNM
                     SGYDDVDLRNFGGQKKKRTAFAQSDTGKQIMTAMIDAVRRKEASGMVERFSHHSFLTLR
                     LCDNICCGCVIRDEYSQETVELPGDAVIVATGGMHGLFGNTTGSLSNTGEVTAELFRLG
                     VPLANGEMIQYHPTTVKCGGKRMLISEAARGEGGRLFAMKDGKQWYFMEEKYPELGNLM
                     PRDITAREIWKVSHESEVFLNMTEISEEIISNKLSGLADDCMTYLHKDIRKEPVSVLPG
                     IHYFMGGILVDEQHRTSIQNLYAAGECCAQYHGANRLGGNSLLGALYGGRVAAKSACEQ
                     ADVVDLSCATQIDFPPASQISEIKQLNKVMQETMGVVRNENTLLNGIQTVQALTGNLPL
                     LGMAVLKSALARKESRGAHWREDYPKSNDDDYLKTTVARFDGKQIQISFVPVPERR"
     CDS             5625..6326
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: 88.3; E-value: 1.1e-27)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg34_6"
                     /sec_met_domain="Fer2_3 (E-value: 2.4e-28, bitscore: 88.3,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00059, bitscore: 10.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LVYKIRIRRQESQKSDSYWQEFEYDGSKNSSVATVLKELNSRTPL
                     KDNSGNIVTPISWECSCMVRKCGACAMLINERPRLACSTFLHTLKGSTIILEPLSKFPL
                     VRDLTVDRSNLFENLKKLNLWLESEAYMSSWTHEPRYQSARCLMCGCCLEVCPNFSANG
                     TFAGTVAAVNAFRILNEEQESTHLNEISAEYKKRFFEGCGKSLSCHDICPIGLPVEELL
                     VRSNAAAVWGK"
     CDS             6407..7315
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     55.2; E-value: 1.8e-17)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg34_7"
                     /sec_met_domain="LysR_substrate (E-value: 2.1e-12,
                     bitscore: 36.7, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 4e-18, bitscore: 55.2,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVQQLKYILKVAEVGSITEAAKLLFISQPSLSNSIKETEKEAGI
                     TIFLRSRIGITLTNDGAEFLGYARQVIQQMELLEDRYVTNLPGKVTFGVSSQHYTFTEN
                     AFVELVKRFGQERYAFYYNETGTHQILDDVKNRVCDLGILYLSHENEVVMRKVIEENHL
                     VFTELFSAKPHVFLQKDHPLVSKKVVSVHDLAPYPRLNFVQGEYESVYFSEELFSSIPV
                     DKEIRVNDRGAIVNFILGLNAYTISSGIFPKYLNGENIISVPLAENETMHIGYVLNENQ
                     KLSELGKSYLEELRKYAPANP"
     CDS             7405..7989
                     /locus_tag="ctg34_8"
                     /transl_table=11
                     /translation="MPMAVLSNFLIYCVINAFTPGPGNILALNTVTNYGYKKGKPLFFG
                     IFAGYYVVQILCAIFVYGVNSLLPNVMEVMKYIGAAYILWLAIHIVFSKPSTENAEQSA
                     SFLKGFMLQFVNVKIYMFGVTALTGYVVGYMSSFPALLFLELVIATIGTIATCTWIGLG
                     VLIQKFYLRHFRVINIILALTLLECIWGMLR"
     CDS             complement(8014..8256)
                     /locus_tag="ctg34_9"
                     /transl_table=11
                     /translation="MRELRNTKIIAVDHGYGNMKTANTVTPTGIKAYETEPIFTGNILE
                     YNGIYYRIGEGHKEFMQWFLQHYGIVRPPSIHLIC"
     CDS             8725..9720
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ROK"
                     /gene_functions="other (smcogs) SMCOG1034:Repressor, ORF,
                     Kinase (Score: 141.7; E-value: 1.1e-43)"
                     /gene_kind="other"
                     /locus_tag="ctg34_10"
                     /sec_met_domain="ROK (E-value: 2.6e-44, bitscore: 141.7,
                     seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTVLANVNDLLEKRVLEETGEYASTGGRKAKSIGINKSYCHAMG
                     ILITANHIEMVLVNLGDEIIKKDRIRLKFTVELSYCTEVAQKVKTFLEGELAKDTLLGI
                     GVAIPGIIDQKERIVLKSHALGIENYSLRFLEQALEIPVYFENDANAAMLAEKKQKYPN
                     AIYLSLNHTLGGAFCIDGKLFRGQNQKAGEFGHMILVPGGRKCYCGKSGCADAYCAASV
                     LTKDNRQSLDAFMKKIESGDEKNLQTWNEYLDHLAVLISNLRMAYDMDIILGGDVGGVL
                     SDYMIPLGEKVMAYNGFEHDVSYLKNCTYKKESSAVGAAKYFFTKYMVEL"
     CDS             10121..11149
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg34_11"
                     /sec_met_domain="ADH_N (E-value: 1.5e-36, bitscore: 114.5,
                     seeds: 68, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 8.2e-29, bitscore:
                     90.2, seeds: 88, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLQQVMTNPGEIIFREVPVPEVKENQVLVKIMNIGVCGSDIHVYH
                     GKHPFTKYPVTQGHEVSGEITELGKNVTEFHVGQKVTIEPQVYCGHCYPCRHGKYNLCE
                     ELKVMGFQTTGTASEFFAVDASKVTPIPEDMSYEEGAMIEPLAVAVHGAKQMGDVAGMN
                     IAVLGAGPIGNLVAQAAKGMGAAKVMITDISDLRLEKAKECGIDVCVNTKNKDFGEAMI
                     EAFGADKADVIYDCAGNNITMGQAIKYARKGSTIVLVAVFAGMAEVDLAVANDHELDIK
                     STMMYRHDDYIDGIRLVNEGKVHLKPLISKTFAFKDYLKAYQYIDDNRETTMKVIINVS
                     EK"
     CDS             11159..12523
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_2"
                     /gene_functions="transport (smcogs) SMCOG1005:MFS sugar
                     transport protein (Score: 413.3; E-value: 3.1e-126)"
                     /gene_kind="transport"
                     /locus_tag="ctg34_12"
                     /sec_met_domain="MFS_2 (E-value: 6.9e-127, bitscore: 413.3,
                     seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGSENKNGKVPLISKIAYGFGDVGCNFSWMFVSNFLMIFYTDVFG
                     ISMAAVSALMLFSRFWDAINDPIVGGLTDKTKSRWGRYRPWLLVAAPITAILLVMTFWA
                     RPDWPQNGKIIYMVITYCLLVLGYTCVNIPYGTLCGAMTQNIDERAKINTSRSVAAMIA
                     IGVLNIITVPLLSKFGSHSAKTGYLTVAVIYGCIFTACHFFCFAKTKEAVITPEKQKIS
                     VKVQLKAVMQNRPYLLALAGQILFGLTLYGRNADILYYFTYVEGNASYYTTYSMCIIIP
                     SIIGAACFQPLFRKLNNKGRVASLFALFTGISMLSMFFFNAKESPAIFYALSGLTQFFF
                     SGFNTAIYAIIPDCVEYGEWKTGLRNDGFQYAFISLGNKIGMAVGTALLAGLLGKYGYI
                     ANQTQNVIVLSIMKHGFTTIPGVFWIVTAVVLFFYRLNKKRYNEIVEELKNGRKS"
     CDS             12507..13469
                     /locus_tag="ctg34_13"
                     /transl_table=11
                     /translation="MEEKVDIVALGELLIDFTEAGHSQDGRKLFEQNPGGAPANLLTVA
                     SHFGYHTSFIGKVGNDMHGKFLKKTLQKEGINTDAIVEDPGYFTTLAFVEIGENGERNF
                     SFARKPGADTQLKKEELDQTLISGCRIFHFGSLSLTDEPAESATIEAVKMAKEAGVLIS
                     YDPNYRPSLWKSKECAVKKMKSVVELVDVMKVSDEESILLTGAKSYEQAAEEILAMGPK
                     LVAVTLGERGVLMATKSRKEIIKAFQVHAVDTTGAGDSFWGGVLCSILSMNKNVEKMEW
                     EEIKKCAVLGNAVAGLCVQKRGGIPAIPTKEAVLEFMQK"
     CDS             13661..13723
                     /locus_tag="ctg34_14"
                     /transl_table=11
                     /translation="MEKITHNIAYRFRIYPNREQE"
ORIGIN
        1 aaaatgaatc gcggggcacg cgaggatagc ttgtagatac ttggctcagt agagccattg
       61 agcaagaagc ccccacttca aaatctgtga tttaagtggt gggagcatgt cacttgtaaa
      121 atttatgggg aactaacatc agcttattga cataaattta aaaataagta taataatagt
      181 tgagtaattg ttcaactatt attatttgga ggtggatata tgtcaaaaac gtcttatatt
      241 tgtaattgcg atgtaattca tgaggatatt gtgaatgatg tgaaatccaa gatgcagcca
      301 aaagatgatt atatccagtt ggcttctttg tttaagctat ttggagatgg aactagagta
      361 caaatcttac acgctctaga acagagtgag atgtgtgtat gtgatcttgc agtgctactg
      421 ggggtaacaa aatctgcaat ttcgcatcag ttaaaggcat tacgcctagc gaatctggta
      481 aaattccgta aagaagcaca gatagtttac tactcgctgg cagatgatca tgtgaaagag
      541 attattgaca agggatttga gcatctttgg cagaaataat attttttaat attatagttg
      601 agtaattgaa caattaaaca aatcataagg agattatcat gaaacgcata tttctattaa
      661 aagggttgga ctgtccaaat tgttccgcaa aaattgaaaa agaagtcgga gagttggatg
      721 gagtgcaatc ctcagtggta aatctgatga agcagacgct tacaatcaat gttactcaga
      781 cagccgcaga tacgatagcc agtcagattg aaacgattgt tcatagtcat gagccagatg
      841 tggaagttca ggaagaaacc gttatgaatg ttacaaagag ttattcgtta aaaggattgg
      901 attgtccgaa ttgttctgca aaaattgaaa aagaagtcgg agaattggat ggagtacaat
      961 cctcagttgt aaatttgatg aagcagacgc tgacaatcaa tgttgctcca gttgccgcaa
     1021 atacaatagc cagtcagatt gaaacgattg tccacagcca tgagccagat gtagaagttt
     1081 ccgaaattgc acaggaatac tatatacctg caaaaaaaca ggataccaat acatcctata
     1141 acaatgagga caagaagttg acagttcgtt tagcgattgg tgcagcaatc tatgctattg
     1201 gtatggcatt gactgttttt gcgaaagtgc cactgcctat cgagttagct tttctcattg
     1261 tttcttatgt tattcttggt ggagatgttg tatggcaggc tgtgaggaac atttcaaagg
     1321 ggcgtgtatt tgatgaacat tttttgatga gtgtttctac gattggggct tttgtcattg
     1381 gtgaatatcc agaagcagtt gctgttatgc tattctatca ggtaggtgaa ttttttcagt
     1441 cattggctgt taagcgttcc agaaaatcta tatcagactt aatggatata cgtccagatt
     1501 ctgctacagt aagaagaaat ggggaattga ttaccatatc tccagaaaat atctccattg
     1561 gtgagattat tattgtaaag cctggtgaaa aaattccatt agacggtgtg gtattggatg
     1621 gagattctat gctggataca agggccttaa caggagaatc agttccgaga agtgttcata
     1681 aaggagacga agcactttcc ggttgtatga accagacggg tgtcttaatg attaagacaa
     1741 cgaaagcatt tggtgaatct accgcttcaa agattattga tcttgtggag aatgcgtcca
     1801 gtagaaaagc accaacagaa aatttcatta ctacatttgc acgttattac actcctgttg
     1861 ttgtaatctt agcagctatt ctggcaattc tgccaccgat ccttcttggt ggaggttgga
     1921 cagagtggat tcgcagagga tttgttttcc ttgtggtatc ttgcccatgt gcattggtca
     1981 tttcaatccc gctgactttc ttcggaggga ttggtgcggc atctaaacga ggtgttcttg
     2041 taaaaggaag taattattta gaggcgctta ataatgtcag cattattgtg ttcgataaaa
     2101 ccggaacact tacaaaaggt gttttcaatg tgacggatat tctgccggca aatggatttt
     2161 caaaagaaca ggttctggag tatgcggccc aggcagagag cttttctaac catcctattg
     2221 caaaatccat tctctctgct tatggaaaag aaattgacca atcagttatc tctgattaca
     2281 aggaaatttc cggatatgga atcagtgcca tggcaggaaa gaagaaagtt tatgctggca
     2341 atacgaaact tatggattca gagcatgtgg agtacacagc ctgtgaaaaa gttggtacaa
     2401 aggtttatgt agcagtagat ggtcaatatg ccggatgcat tttgataaca gatgaagtga
     2461 agccggacag taaaaaagca atttctgacc tgaaacatat cggcgtggaa aaaacagtca
     2521 tgcttaccgg tgatgatgaa aaaattggga agtccgttgc agaagaattg cagttggatg
     2581 aatattatgc acagctgctt cctgaccaaa aagtggaaaa ggttgagctt ttagacagta
     2641 aaaagagacc gggaagcaaa ttggcttttg ttggtgatgg tatcaatgac gctcctgtcc
     2701 ttgcccgtgc agatgttggt attgcaatgg gtgggcttgg ttcggatgcg gccattgaag
     2761 cagcagatgt agttctgatg acagatgaac cgtctaagct ggtggacgcg attgaagtag
     2821 caaaagcgac aaaacagatt gtcatgcaga atatagtgat tgctcttggg attaagagtg
     2881 tgttcctgat tcttggcgct cttggtattg cgggaatgtg ggaagctgta tttggtgatg
     2941 taggcgttac cataattgct gttttgaacg caatgagaat tttgaaaaaa taggaaatga
     3001 ggtgggaatg tgaaacgaaa actgattctg ttagttgtta cgattgcttt tcttgtaggt
     3061 tttggtgtca ttttacattc accgccttct atgattgatg cagtcacagg agcaacaccg
     3121 aagtcaaaaa atgcggctca agcctccgca cagttggaag gctcttatgt tctcggtatt
     3181 aatatgatgt cagatggtct cgacaacgag aacacccgga ataaattaaa agaattggca
     3241 ctggacgatt cggaaacaaa tgaaacagat ctcatgaaaa cggacattag ttttcggtta
     3301 tatgtatctg agacggatta tccgcttgtc agttatgcta agaaactctg tgacaggttg
     3361 aaacaggccg gtttttccgt agatctgaaa gagtacagta acacaatgat gctatcaaga
     3421 gtggtaagtg gaaagtatga tgtattcctg gcatcggatg attttattga cgttacaacg
     3481 ctaacacaga tggactatat gatcatggac agcgaagaaa tgaggtgagc gggaatttat
     3541 gagaaaatgg aatacgattt tgtctgtttt aatgcttctc atttttatga ttcatggaat
     3601 catgggcagc tttatgctga acggagttgg aagtagcgca gggaaacttc ttgcatggat
     3661 tggtgttggt tttcttgttg tgcatacggt gattggtgtc atcctgacag ttcagagttt
     3721 acagacagcg aagcaatccg gaaaaatgta tctgaaacag aacgccatat tctgggcgag
     3781 acgagccagt gggctggcaa tactgatcct gctgttcttc catattggct tgtttggaaa
     3841 ggtgcagaat gggacatata ttttgttccc ttttacaacg gtaaagatgg taactcagct
     3901 tttgttcgtg gcggcaatct ttgttcatat ttttatcaat atccgcccat tgctcgtatc
     3961 gctgggaatc atcagttata aagaacgaag gggtgatatt tatttgattc tttcggtgct
     4021 ccttctgttt atagcgggcg cagttatttt ctattatatt gggtggcaat atctatgagt
     4081 aagacaatta ttattatagg cgctggactg gcaggacttt cagcggcttt gcaggcagcg
     4141 gaaaatggat gcaatgtaaa actggtttcc tcctttccat cagagcgggc gcagtctgtt
     4201 atggcggagg gcggtatcaa cgcagctttg aatacaaaag atgaaaacga cagtcccgaa
     4261 gaacatttca cagatacaat aaaggcggct tgcggtctgg cagacccaaa tgcagtttgg
     4321 ggaatgacac aggcagcacc ggagctggtg cactggctgt taaaacttgg agttcaattt
     4381 aacatgagcg gctatgatga tgtggatctg cggaattttg gcgggcagaa aaagaaaagg
     4441 actgcttttg cgcagagcga taccgggaag cagatcatga cagctatgat agacgctgtt
     4501 cgcaggaaag aagcatctgg tatggtagaa cggttcagcc atcattcttt cctaacactt
     4561 cgtctgtgtg acaatatttg ttgtggctgc gtaatcaggg atgaatacag tcaggagact
     4621 gtggaattac cgggggatgc ggttattgtt gccaccggtg gtatgcacgg attgtttgga
     4681 aatacaacgg gttcgctgag caatacagga gaagtcactg cagaattgtt ccggcttggt
     4741 gttcctctgg caaatggcga gatgatccag tatcatccga caactgtgaa atgtggtgga
     4801 aaacgcatgc tcatcagcga ggcggccaga ggggaaggtg gcaggttgtt tgccatgaaa
     4861 gatggaaaac aatggtattt catggaggaa aaatacccgg agcttggaaa tctgatgcca
     4921 cgagatatta ccgccagaga gatatggaag gtcagccatg aatcagaggt atttcttaac
     4981 atgacggaaa tatcggagga gattatttca aataagctat ctggtctggc agacgattgt
     5041 atgacctatc tgcataaaga tatacgaaag gaaccggtgt ctgttttacc gggaattcac
     5101 tattttatgg gaggcattct ggtggatgag cagcacagaa cgtcgattca gaatctttac
     5161 gctgccggag aatgctgtgc ccaatatcat ggtgccaacc gtcttggtgg aaattctctg
     5221 ttaggagcgt tatacggagg acgtgttgcg gcaaaatcag catgcgaaca ggcagatgta
     5281 gtagatctat cttgtgcgac acagatagat tttccaccag cgtctcaaat ttcagaaata
     5341 aagcaattaa acaaagtgat gcaggagact atgggcgttg tcagaaatga gaatacgttg
     5401 ttaaatggga ttcaaacggt acaagcgctg acaggaaatc ttccattgct tggcatggca
     5461 gttctaaaga gtgctcttgc aagaaaagaa agccgtggtg cacactggcg ggaggattat
     5521 ccgaagagca atgacgatga ttaccttaaa acaacggtag ccagatttga tggaaagcag
     5581 atacagattt cctttgtacc tgttccagaa aggcggtgat tcacttggta tataaaataa
     5641 gaatcaggcg gcaggagagt cagaaatcag acagttattg gcaggaattt gagtatgacg
     5701 gaagcaaaaa cagctctgtt gccactgttc taaaggaatt gaacagtaga acccctttga
     5761 aagataactc aggaaatata gttactccca ttagctggga atgtagctgt atggtgcgaa
     5821 aatgtggggc ttgcgccatg ctgattaacg aacgtccgag gttggcatgc tctacatttc
     5881 tacatacgtt aaaaggttct acaatcatct tggaaccttt aagcaaattt ccgcttgtaa
     5941 gagatttgac cgttgaccgg tcaaatctgt ttgaaaattt gaaaaaactg aacctttggc
     6001 ttgaaagtga agcttatatg agttcgtgga cacatgaacc gagataccag tcggcacgct
     6061 gtctgatgtg tggctgttgc cttgaagtgt gtcctaactt ctctgcaaat gggactttcg
     6121 caggcactgt tgctgcagtc aacgcatttc ggattctgaa tgaagaacag gaaagcactc
     6181 atttgaatga gatttctgct gaatataaga agagattttt tgaaggatgc gggaagtcgt
     6241 tatcttgtca tgatatttgt ccgattggtc tgcctgtgga agaactgctt gtaaggtcga
     6301 atgcagcggc tgtttggggc aaataaaatg gatgataaaa gctataatga atgtatgaag
     6361 agaatcaaaa acttgaggaa tttgtaagaa tgaaaaggat gaagaaatga cggttcaaca
     6421 attaaaatat attttgaagg tagcagaagt tggctctatt accgaagcgg caaaactgct
     6481 ttttatatca cagccaagtc tgtccaattc catcaaagaa acggaaaaag aggctggtat
     6541 cactattttt ctccgcagta gaatcggaat tactctgaca aatgatggtg ctgaatttct
     6601 cggttatgct cgtcaggtga tacagcagat ggaactgctg gaggatcgat atgttacaaa
     6661 tcttccgggg aaagtgacat ttggggtatc ttctcagcac tatactttta cggaaaacgc
     6721 ttttgtggag ttagttaagc gttttggaca agaacgatac gctttttatt ataatgaaac
     6781 cggaacacat cagatattgg atgatgtgaa aaatcgtgtc tgtgatttag gcatccttta
     6841 tttatcgcat gaaaacgaag tcgtcatgcg gaaagtgata gaggaaaacc atctggtgtt
     6901 taccgagctg ttttcagcaa agcctcatgt ttttttgcaa aaagatcacc cattggtatc
     6961 gaaaaaagta gtttccgtcc atgaccttgc accttatcca cggctaaact ttgtacaggg
     7021 agaatatgaa tctgtctatt tctcagagga attattcagc tctatcccgg tggataagga
     7081 aattcgggtc aatgatagag gggctattgt caacttcata ctcggactga atgcctatac
     7141 tatttcaagt ggcattttcc cgaaatattt gaacggagaa aatatcatct ccgttccgct
     7201 tgcagaaaat gaaacaatgc atattggata tgtgctgaat gaaaatcaga aattaagtga
     7261 gcttggaaaa agctatctgg aagaattacg gaaatatgct ccagccaatc catagtcata
     7321 ggctatggat aatcatataa aataggtgtt atgtatgtac cactgtttgc tgatataata
     7381 atagcagaaa ggtggttgat gattatgcct atggcggtac tgagcaattt tctgatttat
     7441 tgcgttataa atgcctttac tccggggccg ggaaatattc tggcattaaa taccgtaaca
     7501 aattatggat ataaaaaagg aaagccgctg ttctttggaa tttttgcagg ctactatgta
     7561 gtacaaatct tatgcgcaat tttcgtatat ggggttaatt ctttgcttcc aaatgtaatg
     7621 gaagtgatga agtacatcgg agcagcctat atcctgtggc ttgcgattca tattgttttc
     7681 agtaagccgt caacagaaaa cgcagagcaa tcggcatcgt ttctgaaagg cttcatgctg
     7741 caatttgtca atgtgaagat ctatatgttc ggagttaccg cactaacggg ttatgttgta
     7801 ggatatatgt cctcttttcc ggctttgctg tttttggagc tggttattgc aacaatcgga
     7861 acgatcgcaa cctgtacttg gattggcttg ggcgtactga ttcagaagtt ttatctgcgg
     7921 catttccgtg ttattaacat tatccttgca ctaacattac tggagtgtat ttggggaatg
     7981 ttaagataat tgttgctttg agagcaattc taattaacaa atcaaatgaa tgctaggtgg
     8041 tcggacaatc ccatagtgct gtagaaacca ctgcataaat tctttgtgtc cttcgccgat
     8101 ccggtagtaa atgccgttgt attccagaat attcccggtg aagattggtt cagtttcata
     8161 ggctttgatg ccggttgggg tgacggtgtt tgctgttttc atattgccat agccatgatc
     8221 tacagcaatg attttggtgt ttctgagttc tcgcataaaa aatgcctccg ttttcgtatt
     8281 gattgattca gcaggtcgta ccggtgtggt actgctttgc tgtgggataa gcatacgaaa
     8341 atcggaggat aaaggcattg aggggaaatt gagttggaat tgagtgaatg tttggaaagt
     8401 tgtaaaattg aatttccatt ttggcaaaga attaccacag taattatgat gagataacgt
     8461 gaatgaaaaa tatagtgagt gggtattcgg taaatttgat tcttaaaagt agtatttctg
     8521 aatgcagcaa atttttatta tagaacatta ctttacaaga agaataaaaa agcatataat
     8581 tcttttgtaa actatttaat aaaagagggt gaggaaacgg aaaataaaga taaaaaaaat
     8641 ataacaagaa aaaaaataat taattatgtt ctaaacaatc atgttacatc caaggcggga
     8701 atcgcaaaag agttaaactt gagtatgccg actgtgttag caaatgtgaa tgacttgtta
     8761 gaaaaaaggg tgttggaaga aactggggaa tatgcttcga ccggtggacg gaaggcaaaa
     8821 agtataggga ttaataagtc atactgtcat gcaatgggaa ttttgattac agcgaatcat
     8881 atagaaatgg tattagtaaa tcttggagat gagattataa aaaaagatcg catccgttta
     8941 aaatttacag tagaattatc ctattgtaca gaggtggcac aaaaggtcaa aacttttctt
     9001 gaaggcgaat tagcgaagga tacgctactt gggattggag tggcgattcc gggaattatt
     9061 gatcagaaag aacggatcgt tttaaaatcc catgctttag gtatagagaa ttatagtctg
     9121 cgttttttag agcaggctct ggaaattcca gtatattttg aaaatgatgc taatgctgca
     9181 atgcttgcag aaaaaaagca aaagtatcca aatgcgatat atctgtcttt gaaccatacc
     9241 ttaggaggcg cattctgcat agatggaaag ctgtttcgag ggcagaacca gaaagcaggg
     9301 gagtttggtc acatgatact cgttcccggt ggaagaaagt gttattgtgg taaatcagga
     9361 tgtgcggatg catattgtgc tgcaagtgta ctgacaaaag ataacaggca gtcactggat
     9421 gcatttatga aaaaaattga aagtggtgat gaaaaaaatt tgcagacatg gaatgagtat
     9481 ctggatcatc ttgctgtttt gatatcaaat ctgcggatgg catatgatat ggatatcata
     9541 ctaggaggtg atgtgggagg ggtattgtca gattatatga taccactggg agaaaaagtg
     9601 atggcatata atggctttga acatgatgtt tcatacttga aaaattgtac gtataagaaa
     9661 gaatcgtcgg ctgttggagc cgcgaaatac ttttttacaa aatatatggt agaattgtaa
     9721 attttttgaa cgcagataag cagtccaccg catctggtgc gtagggcatt aggcgttggg
     9781 taaagggatg tttagtctgt tagagttaaa agctcccact gacaggttgc aaagcgaatg
     9841 cagatgtccg ctttatatgt gtgaaaaacg agaagttgtg taaaattaga aaaagatatt
     9901 atagtaaaaa acggaaagaa aacagtaact acggtttcct ttccgttttt gcgtgttgat
     9961 tgtgaaaaat acacaaaaaa tgtattttga aattatgaaa tatataaaat tatgaaaaaa
    10021 tatattgaca aatcgtgttt acaggacaat aatgtaatta ctttaataaa acattttata
    10081 aaacatgaaa taaaacaata taaaaaagga ggaaacaatt atgttacagc aggtaatgac
    10141 aaatccagga gaaattattt tcagagaggt tccggttccg gaggtgaagg aaaaccaggt
    10201 gttggtaaag attatgaata ttggtgtctg tggatcagat attcatgttt atcatggaaa
    10261 acatccgttt acaaaatatc cggtaacaca gggacatgag gtttcaggtg agatcacaga
    10321 acttggaaaa aatgtcacag agtttcatgt tggacagaag gtgacgatag agccgcaggt
    10381 atattgtgga cactgctatc catgccgtca tggaaagtat aatctttgtg aggaattaaa
    10441 agtaatggga tttcagacga caggaacagc atctgagttt tttgcagtgg atgcatcgaa
    10501 agtaacaccg attccagaag atatgtccta tgaagaagga gctatgatcg aacctcttgc
    10561 ggtggcagtt catggtgcaa aacagatggg cgatgtggct ggcatgaata ttgcagtcct
    10621 tggcgcagga ccgatcggaa atctcgtggc acaggcagca aaaggaatgg gggcagcgaa
    10681 agtgatgatc acagatatca gtgatcttag actggaaaag gcaaaagaat gtggaattga
    10741 tgtgtgtgtg aataccaaaa ataaagactt cggtgaggca atgatcgaag catttggagc
    10801 ggataaggcg gatgtaatct acgactgtgc cggaaacaat atcacaatgg gacaggcaat
    10861 taaatatgca agaaaaggaa gcacgatcgt actggtggct gtttttgcag gaatggcaga
    10921 agtagatctt gcagtggcaa atgaccacga acttgacatt aagagcacga tgatgtaccg
    10981 ccatgatgat tatatagatg gaatcagact ggtaaatgag ggcaaagtgc atttgaaacc
    11041 gcttatctca aagacatttg cttttaaaga ttatctgaag gcataccagt atattgatga
    11101 taaccgtgag acaacgatga aagtaattat caacgtcagt gaaaagtaag gagttcatat
    11161 gggaagcgaa aacaaaaatg ggaaagtacc gttgatcagt aagattgcat atgggtttgg
    11221 tgatgttgga tgtaatttca gctggatgtt cgtcagtaat tttctgatga tattctatac
    11281 agacgtgttt ggaatcagta tggcggctgt gtcagcactt atgctttttt caagattctg
    11341 ggatgcaatc aatgacccaa tcgtcggggg acttacggat aaaacaaaat cgagatgggg
    11401 acggtaccgt ccatggttgt tagtagcggc accaattaca gcgattcttc ttgtcatgac
    11461 attctgggca agacctgact ggccgcagaa tggaaaaatc atttatatgg taattacata
    11521 ttgtctgctg gttttggggt atacctgtgt gaatattcca tatggaacct tgtgtggtgc
    11581 tatgacccag aatattgatg aacgtgcaaa aataaataca tcccgttcgg ttgcggcgat
    11641 gattgcaatt ggtgtgttaa atattatcac agttccactg ctcagcaaat tcggcagtca
    11701 cagtgcaaag acaggatatc tgacggttgc ggtcatatat ggatgtattt ttacagcctg
    11761 tcatttcttc tgctttgcga agacgaaaga ggcagtgatt actccggaaa aacaaaaaat
    11821 ttctgtaaag gtacagttga aagcagtcat gcagaacaga ccatatcttc ttgcattggc
    11881 aggacagata ttatttggat taacattata tggcagaaac gcagatattc tgtattattt
    11941 tacatatgtg gaagggaacg cctcctacta cacaacttat tcgatgtgca tcattattcc
    12001 ttctatcatc ggggcagcct gttttcaacc attattccgc aagttgaata acaaaggaag
    12061 agtagcatct ctctttgctt tatttacagg aatttctatg ttgtctatgt tttttttcaa
    12121 tgccaaagaa tcaccagcta ttttttatgc attatctggg ctgacacagt tctttttctc
    12181 tggatttaat accgcaatct atgcaattat tccggactgt gtggaatatg gggagtggaa
    12241 aacaggactt agaaatgacg ggtttcagta tgcgtttatt tcacttggaa ataaaatcgg
    12301 aatggcagtt ggaacagcac ttttagcagg attacttgga aaatatggtt atattgcaaa
    12361 tcagacacaa aatgtaattg tactttcaat tatgaaacat ggatttacga cgattccagg
    12421 tgtattttgg attgtgactg cggttgtatt atttttctac cggttaaata aaaaacgtta
    12481 taacgagatt gtggaggaac tgaaaaatgg aagaaaaagt tgatatcgtg gcattgggag
    12541 aattgttgat tgattttacg gaagcaggac acagtcagga tggaagaaaa ttgttcgaac
    12601 agaatcccgg cggtgctccg gcaaatcttc taactgttgc aagccacttt gggtatcata
    12661 catcttttat tggaaaagtt ggaaacgata tgcatggtaa atttttaaag aagacattgc
    12721 aaaaggaagg aattaatacg gatgctattg ttgaagaccc gggttatttt acaacgttgg
    12781 catttgtgga aatcggtgaa aatggagaaa gaaatttttc ttttgcaaga aaaccgggtg
    12841 cagatacaca gttaaaaaaa gaagaactgg atcagacgtt aatttccgga tgcagaattt
    12901 ttcattttgg atcattatcg ctgacagacg aaccggcaga aagcgcaacg atcgaagcag
    12961 taaaaatggc aaaagaagcg ggtgtactta tttcctacga cccgaattac cgtccatccc
    13021 tgtggaaaag taaagagtgt gcagtgaaaa aaatgaaatc tgttgtagaa ctggtagatg
    13081 tcatgaaggt atcggatgaa gagagtattc tcctgacagg ggcaaaaagt tatgagcagg
    13141 ctgcagaaga aattcttgct atgggaccga agttggttgc cgttacattg ggagaacggg
    13201 gcgttcttat ggcaacaaaa agcagaaaag aaatcatcaa agcatttcag gtacatgcag
    13261 tcgatacgac tggtgcaggt gattcattct ggggaggtgt attatgcagt atcctttcta
    13321 tgaataagaa tgttgaaaaa atggaatggg aagaaatcaa aaagtgtgct gttttgggaa
    13381 atgcagttgc aggattgtgt gtgcaaaaga gaggtggaat ccctgcaatt ccgacgaaag
    13441 aagcagtgct tgaatttatg cagaaataat gaacgtatat gaacaaaatc ggggctgtaa
    13501 aaactcccct atttttaaca agagctagca agaattctcc tctacaggtg ggagatgaat
    13561 tgcaaaataa atacagcaaa tacagacaga acacttgttc tatctaaagg gatatagtat
    13621 aatataatca gtcgaaacga tggaaagcga ggctgatcat atggaaaaaa taactcataa
    13681 catagcttac cgttttcgta tatatccaaa ccgagaacag gaagt
//
