LOCUS       NC_020291.1            23501 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_020291.1 Clostridium saccharoperbutylacetonicum N1-4(HMT),
            complete sequence.
ACCESSION   NC_020291
VERSION     NC_020291.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-13 23:47:19
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 492254
            Orig. end    :: 515755
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..441
                     /locus_tag="ctg1_395"
                     /transl_table=11
                     /translation="MGGKWKGNVMKKIFIAISIILIILTIGIYNNSQTVKLFENVDTES
                     VDEISIAYIGGSFSTEDKSQISEIMNYLKRLKFSKCSNNNVPNTTPDASISLIGKNQGS
                     LRAIKIYGNVVRVYPKENDDYIVDAHIYDDLEKLCKKYKNSK"
     protocluster    1..23501
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[501607:506403]"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      9354..14149
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
     cand_cluster    1..23501
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /kind="single"
                     /product="acetate2butyrate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..23501
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="acetate2butyrate"
                     /region_number="2"
                     /rules="(not (POR or POR_N or PFOR_II) and minimum(4,
                     [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF, ETF_alpha,
                     HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and minimum(1,
                     [EC1_2-faecali, ECH1_Enoyl_CoA_DH1, ECH1_Enoyl_CoA_DH2,
                     ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4, Thiolase_C]))"
                     /tool="gutsmash"
     CDS             1341..2321
                     /locus_tag="ctg1_396"
                     /transl_table=11
                     /translation="MHKKFRLVMSIFLFLICSAFLINVGGTYIKNRIWDYLSSKVDNSE
                     YLMKNMNIYRDTPAWELALAVEDERTSTIERIAKRSPELLNYQDSKYGETLLLWAVGME
                     KYNSAETLLKCGADANIATIDEGETPLLLAADYSWIDTKYKKDPKYVKLLLSYGADPNK
                     RYIGKKRDSTEYGTTPLIKSIGCGIEKTKALVEGGADINLKTKSGNTAAAEALRHVGST
                     SMFREMEYAYYLIVDKKAKVNEFYYSPEYVLIPGDDPNIKFYPVDLLRDWTPELNSEGY
                     KMKMEIVDEFARQGVNYWNTTIPKDVISQIKEIYPHDWEEYLKKY"
     CDS             2408..2725
                     /locus_tag="ctg1_397"
                     /transl_table=11
                     /translation="MKKYRYIQMYYLLYVIVIIFALGTIIIFKNLFVIILDSVCIGISL
                     IDIINKSMSSIYIDNTTIIQSGIHRKKIMYFSEIERIIKLPTSKGKKIFYNCITITNLF
                     F"
     CDS             2784..3098
                     /locus_tag="ctg1_398"
                     /transl_table=11
                     /translation="MFILFLYAICFPSSKYFYFKSPYENNKRVLIVNETYFLGSGTGYF
                     YERKNIIFIKCMNQSINYDSTPFSNREVKVKWLDEKNVQIDYINNSVGHHETELIKFDE
                     "
     CDS             3115..3471
                     /locus_tag="ctg1_399"
                     /transl_table=11
                     /translation="MMKIYKLDEMKISIMNKIEIERFILISIIGLMDSLSVDAISIEEC
                     EMYLFSPYSVEKLNTLNLDEQIVELVENGYELEDVESLIPEELYKSIDKIRLKAIELLK
                     NLPREGVDIKKWLD"
     CDS             3813..4313
                     /locus_tag="ctg1_400"
                     /transl_table=11
                     /translation="LKKIIQIGISDFKELIEGNNYFVDKSLLIKEFLENGAKITLTPRP
                     RRFGKTLNLSMIKYFFDIRSKEETKDLFNGLKIENEKEIMKRQWQYPVVFISFKGIKYN
                     NFEHAIMAMGMLMSDVYKEYRYLMESNIFKEDEKRDFDKIINREADLVLLTASIKNLTY
                     YAK"
     CDS             4570..4746
                     /locus_tag="ctg1_401"
                     /transl_table=11
                     /translation="MKKDLKFNVFYGTEDFTKLFDNLIEDKIKNVTENIKNARYNKSDK
                     DYSSAQKEMDENE"
     CDS             4739..6295
                     /locus_tag="ctg1_402"
                     /transl_table=11
                     /translation="MNKVWNIGIYARVSTEKVEQSESVASQVGNLKEWIIQAAKKDKYS
                     VYNLIKTYEDNGISGSTIDRDAFKRMAEDIENKKINMVLTRDLSRFSRNYLEAGEYIEK
                     YFKLNNVRFVAVLDNVDNSLVEDDDIIPFKNLINEMYIKDSSRKIKSALRERMQRGSSI
                     AAKPPYGYKYEKIYNGEQKTNVLVPEGGETTETIKEIFSLYLKGWGAGKIATYLNQKGI
                     ATPSSKTENYARSKFGLWTNNTIFSILQNHKYGGFLVQQKYRKVSYKMKEVKKTSQEDW
                     VWSGEFEGIIDKETFNRVQEMLKKRSNGYRYKGAVIHPFSSVLRCGTCGGSLSYRKKFE
                     GYKCTLSQSGAKRCTCHSIKEKDLISQIQSNIRTMIDKSINKEKYYNKVENIKIEQDNA
                     KEIREIESELEKLDVKFAKLYEDKLNDLISERNFTNFIKVIQEKQEKLIKRKEELENIM
                     DKSQGNTDITSIYREELNKLFNLEEIERSFVETIIDKIVVNEDSETKEKSIDIYYKFNK
                     N"
     CDS             6484..7302
                     /locus_tag="ctg1_403"
                     /transl_table=11
                     /translation="VATATCIGLSAVKLLKQDANAVMVVLPSDHYIQGEKNYIDTISQG
                     IDTANKRRCIVTLGIEPSRPETGYGYIEMGERTTGNIPTYKIARFTEKPNLEVAKDFIL
                     KGTYLWNSGMFIFRADVILREIEKYLPKLHRSLMEIYKSLGEENEESVIKEQYEMIDGI
                     SIDFGVMQRTRKAYVIKCDFSWDDMGSFGALSRLLNTYRNNNISKNVYVDDCENCSIFG
                     NKNLIIGFGIKDLVVVDAGDVILVMDKNKDQEIKHLINKLNENQEYSKFL"
     CDS             7555..8136
                     /locus_tag="ctg1_404"
                     /transl_table=11
                     /translation="MINTHKIMAENIIKRANTKSIYLLNDKRFIWGNIKPDCAPKYKFK
                     KHYFDESIEMIIDKIIYLSSLTLEDVYFDLTVGKFSEELGVICHFLCDFFCAPHYYRWE
                     FKNTKAVKKHMAYENRLAKIAKEFKPLGIINTNVKSSNIEEFILELQKQYNGAVEFKND
                     LTFSYYVCDSVLNMILNNVFLNDKKVSKAI"
     CDS             8395..9030
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CoA_binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_405"
                     /sec_met_domain="CoA_binding (E-value: 3.1e-22, bitscore:
                     77.5, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKSRNISMAVIKRLPKYYRYLEELMKNDVDRISSKELGEKIGFT
                     ASQIRQDLNCFGDFGQQGYGYNVKELYNQISSILGLDRGYQAALVGAGNIGQAVSNYSR
                     FENLGFKITSIFDANPKLIGMRIRDVEIKDIDDMSTVLQERKIDIGIICVPRKNAQVVA
                     DELIKGGVRAIWNFAPVDLVVPDHVKVENVHLSESLLTLIYLLNESDN"
     CDS             9354..10139
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: EC1_2-faecali"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_406"
                     /sec_met_domain="EC1_2-faecali (E-value: 6.2e-88, bitscore:
                     292.7, seeds: 67, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELKNVILEKEGHLAIVTINRPKALNALNSETLKDIDAVLDDLEN
                     DTNVYAVIVTGAGEKSFVAGADISEMKDLNEEQGKEFGILGNKVFRRLEKLDKPVIAAV
                     SGFALGGGCELAMSCDIRIASVKAKFGQPEAGLGITPGFGGTQRLARIVGPGKAKELIY
                     TCDLINAEEAYRIGLVNKIVPLESLMDEAKAMANKIAANAPKAVAYCKDAIDRGMQVDI
                     DAAILIEAEDFGKCFATEDQTEGMTAFLERRAEKNFQNK"
     CDS             10244..11383
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_407"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.5e-52, bitscore:
                     176.2, seeds: 49, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 5.1e-27, bitscore:
                     92.3, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.4e-34, bitscore:
                     117.5, seeds: 796, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFKLTREQELVQQMVREFAVNEVKPIAAEIDETERFPMENVEIM
                     AKLGMMGIPFSKEFGGAGGDVLSYIIAVEELSKVCGTTGVILSAHTSLCASVINENGTK
                     EQREKYLPDLCSGKKIGAFGLTEPGAGTDAAGQQTTAVLEGDHYVLNGSKIFITNGGVA
                     ETFIIFAMTDKSKGTKGISAFIVEKSFPGFSIGKLENKMGIRASSTTELVMENCIVPKE
                     NLLSQEGKGFGIAMKTLDGGRIGIAAQALGIAEGAFEEAVNYMKERKQFGKPLSAFQGL
                     QWYIAEMDVKIQAAKYLVYLAATKKQAGQPYSLEAARAKLFAADVAMEVTTKAVQIFGG
                     YGYTKEYPVERMMRDAKITEIYEGTSEVQKMVIAGSILR"
     CDS             11397..12176
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 168;
                     E-value: 6.5e-52)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_408"
                     /sec_met_domain="ETF (E-value: 6e-50, bitscore: 168.0,
                     seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIVVCVKQVPDTTAVKIDPKTGTLIRDGVPSIMNPEDKHALEGA
                     LQLKEQVGGKVTVVSMGLPMAKAVLREALCMGADEAILLTDRAMGGADTLATSKAIAGV
                     IAKLDYDLVFAGRQAIDGDTAQVGPEIAEHLNIPQVTYVQDVKVEGKSLIVNRALEDGH
                     QVIEVKTPCLLTAIEELNETRYMHVAKIFETSDDEIKVMSAADIDVDVAELGLKGSPTK
                     VKKSMTKEVKGAGEIVREAPKNAAYYVVGKLKEKHYI"
     CDS             12199..13206
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF_alpha"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 175.1;
                     E-value: 4.3e-54)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_409"
                     /sec_met_domain="ETF (E-value: 4e-52, bitscore: 175.1,
                     seeds: 129, tool: rule-based-clusters)"
                     /sec_met_domain="ETF_alpha (E-value: 4.2e-37, bitscore:
                     124.5, seeds: 511, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIADYKGVWVFAEQREGQLQKVSLELLGEGRRIADELGVKLTAL
                     LLGNNIETLAKTLAEHGADEVLVADDKNLEHYTTEGYTKVICDLATERKPGILFVGATF
                     IGRDLGPRIAARLSTGLTADCTSLDVDVTNGDLLATRPAFGGNLMATIACPDHRPQMAT
                     VRPGVFAKITTDPSKCNIEKVTVKLADSDIRTKVLETIKSKKDIVDIAEADFIVAGGRG
                     VGNKENFTLLKELADALGGTVAGSRAAVEKGWIDGAYQVGQTGKTVKPQIYIACGISGA
                     IQHVAGMQDSDLIIAVNKDDSAPIMKIADYAIVGDLTKVVPELIAQVKEIKSAE"
     CDS             13301..14149
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_410"
                     /sec_met_domain="HCDH (E-value: 1.7e-37, bitscore: 126.4,
                     seeds: 68, tool: rule-based-clusters)"
                     /sec_met_domain="HCDH_N (E-value: 2e-70, bitscore: 234.7,
                     seeds: 60, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIFVLGAGTMGAGIVQAFAQNGCEVIVRDIKDEFVDRGIAGIS
                     KGLEKLVAKGKMTEEDREAILSRISGTTDMNLAADCDLVVEAAIENMKIKKEIFAELDG
                     ICKPETILASNTSSLSITEVASATKRADKVIGMHFFNPAPIMKLVEVIRGAATSQETFD
                     TVKELSEAIGKTPVEVAEAPGFVVNRILIPMINEATFILQEGVASAEDIDAAMKLGANH
                     PMGPLALGDLVGLDVCLAIMDVLYNETGDSKYRASSLLRKYVRAGWLGRKSGKGFYDYS
                     K"
     CDS             14302..15468
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035:Iron-containing alcohol dehydrogenase (Score:
                     388.8; E-value: 7.1e-119)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_411"
                     /sec_met_domain="Fe-ADH (E-value: 6.6e-117, bitscore:
                     388.8, seeds: 219, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMRFTLPRDIYYGKGSLEQLKTLKGKKAVLVLGGGSMKKFGFVDK
                     ALEYLKEAGIEVKLIEGVEPDPSVETVFKGAETMREFGPDWIISMGGGSPIDAAKAMWI
                     FYEYPDFTFEKAVVPFGLPELRQKAKFIAIPSTSGTATEVTAFSVITDYKTEIKYPLAD
                     FNITPDIAIVDSELAETMPATLTAHTGMDALTHAIEAYVATLHSPFTDPLALQAIEMIR
                     DFLLKSYEGDKDAREQMHYSQCLAGMAFSNALLGITHSMAHKTGAVFHIPHGCANAIYL
                     PYVIDFNKKTALDRYAYIAKRLGLSGTTDDELVDSLTNLIKEFNKKMSIPLTLKEYGID
                     EEVFKAKVDMISERAIADACTGSNPRQLNKDEMKKIFECIYYGNKVDF"
     CDS             15615..16028
                     /locus_tag="ctg1_412"
                     /transl_table=11
                     /translation="MLKEMVKKYREEKYDLNCAESIIYAANEEYDLNLSNETLKVMSGF
                     GGGMGIGHICGVITASVGVIGVMFTEISGHKSPRVKEMTQEFINNLQDKLGYIKCDDLK
                     KEYTNVKKCTLMIETGAEILEEIILKEKQNKIL"
     CDS             16052..16978
                     /locus_tag="ctg1_413"
                     /transl_table=11
                     /translation="MDYKSVKFHDNYIVIEEVKNFKLKHIFECGQIFRFEEIAEGHYIV
                     IAFGKLIEVKEEGANIIIYNATEEEVNEIWIKYFDLDRDYSEIKQELSKDPLLKQSIEF
                     GYGVRVLNQDPFEMLISFIISARNNIPSIKKTVNKISNKWGKEIIYKEKTYYAFPSINE
                     IKDATLEEIQETGASFRSKYILDTIKNVYASDKVMDDSNLDKKNSYLKYNLDYIKNLKD
                     DECHEALQEFKGVGAKVADCIMLFSMGKTSAFPVDVWVKRAMIHFYGAENSSLNKIRIF
                     GRNEFGKLSGFAQQYLFYYARENKIEV"
     CDS             17323..18810
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_414"
                     /sec_met_domain="Fer4 (E-value: 1.8e-08, bitscore: 32.3,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.015, bitscore: 14.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQFENRLLKLKHEVLTRVVVLAKENKLCKEELEKIPFEMIVGDE
                     PNYRETVDRERNIVLERAKLAAGYMPNGKNGQELVEIDEEKQILYVIKEACDRCPTNKF
                     QVTDSCRNCVAHKCQSVCNFGAISYVNGKAYIDPDKCKECGMCNKVCPYDAIAEDMRPC
                     KKACPTGALSYNADDLRAEITESKCVNCGACMSECPFGAIEDKSSLVRVVNRLMEKENI
                     YAIVAPAITGEFGAKTTYGQVKNAIKALGFTDMVEVACGADAVTVHESTEFVERMEKGD
                     SYMTNSCCPGFLSYIEKMMPDQAERISGTVSPMVATGRYIKAKHKDAKVVFIGPCTAKK
                     SEVLIESIKDAVDYALTFEELIALFDAFEIDPEKCEDIVVDQASIFGRNFAVGGGLTAA
                     IENFIQEKGVEIEFKPVKVSGGAEIKKTMTMAKVGKLPGNFIEGMMCEGGCINGAAKIA
                     PVMKAKAPFTKINQQTTIKTVLSNKALEEYHNIDLER"
     CDS             19120..19404
                     /locus_tag="ctg1_415"
                     /transl_table=11
                     /translation="MKIKPLGERVVIKKLEAEEKTKSGIVLTGTAKERPQEAEVVAVGP
                     GAVVDGNRVPMEVKVGDKVLYSKYAGSEVKVDGEEYTILKQDDILAIVE"
     CDS             19487..21112
                     /locus_tag="ctg1_416"
                     /transl_table=11
                     /translation="MAKMLKFGEEARRSMQIGVDKLADTVKVTLGPKGRNVVLDKKFGA
                     PLITNDGVSIAREIELEDPYENMGAQLVKEVATKTNDVAGDGTTTATLLAQAIIREGLK
                     NVTAGANPILIRTGIKMAVEKAVEEIKKISKQVDGKEDIARVAAISAADEEVGKLIADA
                     MEKVGNEGVITIEESKSMGTELDVVEGMQFDRGYVSPYMATDTEKMEAVLENPYILITD
                     KKISNIQEILPVLEQIVQSGKKLLIIAEDIEGEAMATLVVNKLRGTFTCVAVKAPGFGD
                     RRKEMLQDIATLTGGTVIAEELGRELKDVTIDMLGTADSVKVNKENTVIVNGKGDSNGI
                     KERINQIKVQIEETTSEFDKEKLQERLAKLAGGVAVIKVGAATETELKEKKLRIEDALN
                     ATKAAVEEGIVAGGGTAYVNVINEVAKLTSDVADTQVGISIIVKALEEPVRQIAANAGV
                     EGSVIIEKVKNSEPGIGYDALHDQYINMIKGGIVDPTKVTRSALQNAASVASTFLTTEA
                     AVADIPSKEPAMPGAPGMGMDGMY"
     CDS             21272..21685
                     /locus_tag="ctg1_417"
                     /transl_table=11
                     /translation="MIKHGSKIEIKHVYYNDRKRKEGFTLIEMIAVIAMIGILAAALLP
                     KIGGYIKQAKKTKILDQCRKVVMAVDSYNLTSNTPVEQTATIDDVEKVAGVETYLDGVS
                     LSNLDTEKTNIKKCYDIVAGEEFDIDNEEKLIN"
     CDS             22044..23501
                     /locus_tag="ctg1_418"
                     /transl_table=11
                     /translation="MAKIIKTAYTFDDVLLVPNKSEILPREVSTKTKLTKTIELNIPLM
                     SAGMDTVTESKMAIAMAREGGIGIIHKNMTIEQQAKEVDRVKRQENGVITDPIYLSQDH
                     LIQDAENLMAQYRISGVPITTEEGKLIGIITNRDIIFETDFQRKISEVMTKENLITASE
                     STTVEEAKEILKKHKVEKLPLVDENGILKGLITMKDIEKVRKFPNAAKDSKGRLLCGAA
                     VGVTGNMMERIDALVKAQVDVVTLDTAHGHSKGVLDAVTQIKKAYPELQVIAGNIATAE
                     ATEDLIKAGADCVKVGIGPGSICTTRVVAGVGVPQLTAVMDCAEVGRKYGIPVIADGGL
                     KYSGDIVKALAAGASVAMMGSLFAGCDEAPGEMEIYQGRSYKVYRGMGSLAAMECGSKD
                     RYFQEGNKKLVPEGVEGRVAYKGLVSDTIFQLLGGIKSGLGYLGSKNFDILYETANFVV
                     QTASGQRESHPHDINITKEAPNYSVGQ"
ORIGIN
        1 atgggaggga aatggaaggg gaatgttatg aaaaaaatat ttatagcaat aagcataatt
       61 cttataatac taacaattgg aatatacaat aatagccaaa ctgtaaaact ttttgaaaat
      121 gtggatacag aaagtgttga tgaaatctca attgcatata ttggtggaag ctttagtact
      181 gaggataaaa gtcaaatatc agaaattatg aactatttaa agcgtttaaa attttctaaa
      241 tgttctaata ataatgtacc taatactact ccagatgctt ctatttcatt gattggcaaa
      301 aatcaaggta gtcttagagc tataaaaatt tatggaaatg tagttagagt ctatcctaaa
      361 gaaaatgatg attatatagt tgatgcacat atatatgatg atcttgaaaa gctatgtaaa
      421 aagtataaaa atagtaaata ataaacataa gatctagcat aacgcttttg tgtgattaag
      481 aatattatat caagtaagtg ggtgtaagat ggaactttag cttttatatc atataaacag
      541 tgatattagc agtattttta gtaactaaaa aagtgtatca aattcggaga atttatatta
      601 tagataaagc ctcatttttg ttaactataa ctgaaatgag gtttcatatt tgcggaaaaa
      661 ttattttata aaacgtattg gctaacagag gatctaggat tgtattacaa gattgagaga
      721 ataattggga tcaactttat ggaaattcaa aggatgttga agaatcaata acatttgtaa
      781 aagaattcat taaagctcat aaagattcac atataaagtt tgttggcact caaaaggtgg
      841 agcagaagca ctaataaatg cagtagctac gggtaaagat gcaatagtat ttaatccagc
      901 agcacctaac tttgaagata ttggattaaa tccgtcaaac tatcatggta aagcagtatc
      961 atttgttgta acaggtgaaa tattaaatga tattcaagga gataaagcat tacgaaaagt
     1021 tggaaatgtg tgttatttat ctcaacaata tcaagagtta gattataaca acaattatga
     1081 agaagcccaa acttcgatag ctacttataa tactgtagtt gaaatagaaa atcatatgat
     1141 ggaagctgta aaaaaagcac taaaagagaa tactattaaa attaaagggc gactatgatg
     1201 taatataggc aaatgtatca tcttgatttg taacaagctt tgagataagc taggttaaaa
     1261 aatagtatat tagtatgttt gctattattt aattttagat atataagtaa ttattttaaa
     1321 ttataaaggg gaagaattat atgcataaaa aatttagatt agttatgtct atttttttgt
     1381 ttttaatatg ttcagctttt ctgataaacg taggaggaac atatataaaa aatagaatat
     1441 gggattatct ttcaagtaaa gttgataata gtgaatatct gatgaaaaac atgaatattt
     1501 atagagatac tccagcatgg gaattagctt tggctgtgga agatgagagg acaagtacta
     1561 tagaaagaat agctaagaga agtccggaac tattaaatta tcaagattca aagtatggag
     1621 aaactttatt attgtgggca gtagggatgg aaaagtataa ttcggcagaa acattattaa
     1681 aatgtggagc agatgctaat atagcaacga tagatgaagg tgaaacgcct cttcttttag
     1741 cagctgacta ttcttggata gatactaaat acaaaaaaga tcctaaatat gtaaagttat
     1801 tattaagtta tggagcagat cctaataaac gctatatcgg gaaaaaacgt gattctacag
     1861 aatatggtac aactcctttg ataaagtcta ttggatgtgg tattgagaaa acaaaagctt
     1921 tagttgaagg tggagctgat attaatttga aaaccaaaag tgggaataca gctgcagctg
     1981 aagcattgag acatgtggga tcgacttcta tgtttagaga aatggaatat gcatattatt
     2041 taattgtaga taaaaaagcc aaagtaaacg aattttatta tagcccggaa tatgttttaa
     2101 taccaggtga tgaccctaat ataaaatttt atccagttga tttactgagg gattggactc
     2161 cagaattgaa ttcagaagga tataaaatga agatggagat tgtagatgaa tttgctagac
     2221 aaggggtgaa ttattggaat actacgatac ctaaagatgt tatttctcaa attaaagaaa
     2281 tttatccaca tgattgggaa gaatatttaa agaaatatta gtagttactc ttgatattgc
     2341 cgaaggggaa gcaattcaag aaaagttata tgaaaaatgg ggaatagaag atgaataagg
     2401 agaggttatg aaaaaatata ggtatataca aatgtattat ttgttatatg ttattgtaat
     2461 aatatttgca ttgggaacaa ttattatttt taaaaacttg tttgtaataa ttttagattc
     2521 tgtgtgcata ggtatatctt tgattgatat tattaataaa tctatgtcaa gtatttatat
     2581 tgataatact acaataatac agagtggtat tcatagaaaa aaaataatgt atttcagcga
     2641 aattgaaaga attattaagt taccaactag taaagggaaa aaaatttttt ataattgcat
     2701 tactattacc aatttgtttt tttgattaca acaagaataa agttagcaaa aagactctta
     2761 ttgtttttaa tatcataata gcaatgttta ttctattttt atatgcgatt tgttttcctt
     2821 cgagcaaata tttttatttt aaatcgccat atgaaaataa taaaagagtg ttgattgtaa
     2881 atgaaacata ttttctagga agtggaacag gctacttcta tgaacgtaaa aatataattt
     2941 ttataaaatg tatgaatcaa tctattaact atgacagtac tcctttttca aatagggaag
     3001 taaaagtaaa atggttagat gaaaaaaatg tacaaataga ctatatcaat aactcagtag
     3061 gccatcatga aacggaatta ataaaatttg atgaatagag aatgagtggt tataatgatg
     3121 aaaatttata aattggatga aatgaaaatt agcataatga ataaaattga aattgagaga
     3181 ttcatattaa taagtataat aggattaatg gattccttaa gtgttgatgc aatatcaata
     3241 gaagagtgtg aaatgtatct tttttctcca tattctgtag agaaattaaa tactttaaat
     3301 ttggatgaac aaatagtaga attggttgag aatggttatg aattagaaga tgttgaatct
     3361 cttattccag aagaattgta taaatcaata gataaaatta gattaaaagc gattgagtta
     3421 ctaaaaaatt tacctagaga gggagtagat attaaaaagt ggcttgatta ataataaaat
     3481 taggttaatc gataacataa tttgggaatg attataatgg gtatagattg aagaaatcta
     3541 tacctagtta tttttctata gagtagaaaa atgtttaaaa gattattagg aaagtttgaa
     3601 gaagtcagca attaggatat aataaaaata ggtataaaac aaaataaata aataaataaa
     3661 taaataaaaa gttcaaatca tacttgtcaa aggaatcaga tcaatgattg aattaggaac
     3721 atgaaaagaa ataacagatc caagattgaa tgatccgaat tgcagcatgg ctactctgtc
     3781 aagaagtgta tattttgggg agggtgaatt gattgaaaaa aataatacaa ataggaatct
     3841 ctgattttaa agagttaata gaaggaaata attatttcgt agataaaagt ttactaataa
     3901 aagaattttt agagaatgga gcaaagatta ctcttactcc tagaccaaga aggtttggta
     3961 aaactttgaa tttaagtatg attaaatact tctttgatat aagaagtaaa gaagaaacaa
     4021 aggatttgtt taacggatta aaaatagaaa atgaaaaaga aataatgaag cgtcaatggc
     4081 aatatccagt tgtgtttatt agctttaaag gaattaaata caataatttt gaacatgcaa
     4141 taatggcaat gggaatgctc atgtcagatg tttataaaga atatagatat ttgatggaaa
     4201 gtaacatttt caaagaggat gaaaaaagag attttgataa aattattaat agagaggctg
     4261 atttagtgtt attaacagct tcaataaaaa atcttactta ttatgcaaag taaggaataa
     4321 ataagtttta ataataaatt agattatgta tttaaagtca tagagtttgt actctatggc
     4381 ttttatatgt gtacctaaat tataaaataa gatatttctt tattttttca gaagagtatg
     4441 aaaatcgaga taaattatag gtgtaatcaa atttgaattt tatatcggtg taatatttcc
     4501 aactttggta ataaaaataa aaaattctta ttagaattat aataaggaat aattgagagg
     4561 aaatctttta tgaaaaaaga tctgaagttt aatgtgtttt atggcacaga agatttcaca
     4621 aagttatttg ataacttaat agaagataaa ataaaaaatg taacagaaaa tattaagaat
     4681 gcacgctata ataaaagtga taaagactat tcatccgcac aaaaagagat ggatgaaaat
     4741 gaataaagta tggaatatag gaatttatgc tagggtaagc acagaaaagg ttgaacagag
     4801 tgaatcagtt gcttcacaag ttggaaattt aaaagaatgg attattcagg ctgccaaaaa
     4861 agataaatat agtgtttata atttaattaa aacatatgag gataatggaa tatctggttc
     4921 tactattgat agggatgctt ttaaaagaat ggcagaagat atagagaata aaaaaattaa
     4981 tatggttttg acaagagacc tatctagatt ttcaaggaac tacttagagg ctggagaata
     5041 cattgaaaaa tattttaaac ttaataatgt tagatttgtt gcggttttag ataatgtaga
     5101 taattcactg gtagaagatg atgatataat tccatttaaa aatttaatta atgaaatgta
     5161 cattaaggat tctagtagaa aaataaaaag tgcgttaaga gaaagaatgc aaagaggatc
     5221 atctattgca gctaaaccac catatggtta taagtatgaa aaaatatata atggagagca
     5281 aaagacaaat gtcttagttc cagaaggtgg agaaactaca gaaacaatta aagaaatttt
     5341 ttctctatat ttaaaaggct ggggagcagg aaaaatagca acatatttaa atcaaaaagg
     5401 tatagcaact ccttcttcaa aaacagaaaa ttatgctcgc tctaagtttg gactttggac
     5461 aaacaataca atattttcga tattacaaaa tcataaatat ggcggttttt tagtacagca
     5521 aaaatataga aaagttagtt ataaaatgaa agaagttaag aaaacatcac aagaagattg
     5581 ggtttggtct ggggaatttg aaggaataat agataaggaa acttttaatc gggttcagga
     5641 aatgcttaaa aaaagatcaa atggatacag gtataaggga gctgttatac atccgttcag
     5701 ttcagtatta agatgcggaa cctgtggagg aagtttatcc tatagaaaaa aatttgaagg
     5761 atataagtgt acattatctc aaagtggtgc aaaaagatgt acttgtcata gcataaagga
     5821 aaaagatttg atttcacaaa tacaaagcaa tataagaaca atgatagata aaagcattaa
     5881 taaagaaaag tattacaata aagtagaaaa tataaaaatt gagcaagata atgcaaaaga
     5941 aataagagaa atagaaagtg aattagagaa attagatgtg aaatttgcga agctgtatga
     6001 agataagtta aatgatctga tttcagagag aaattttact aatttcatta aggtcataca
     6061 agaaaaacaa gaaaagttaa ttaagaggaa agaagaacta gaaaatatta tggacaagtc
     6121 acaaggcaat actgatatta caagcatata tagggaagaa cttaataaac ttttcaattt
     6181 agaagaaata gaaagaagtt ttgtggaaac aattatagat aagatagtag tcaatgaaga
     6241 ttctgagaca aaagaaaaga gtattgatat ctattataaa ttcaataaaa attaaaattt
     6301 ccaatattgt ttaatatcag aacagaaatt attataccca tttattttca aatgggtata
     6361 ataataatat agaataattt cgaaactcaa gttttaaaat taagagatgg cggtaagtgg
     6421 aaaatgtaat tggcaaaaaa gaaattgaat ggattttaga ataaaaagac caataacgtc
     6481 agtgtggcaa ctgctacatg catagggtta tcagcggtga aattattaaa acaagatgct
     6541 aatgcagtta tggttgtatt accatcagat cactacattc aaggtgagaa gaattatata
     6601 gataccatat ctcaaggaat tgatacggct aataaaagaa gatgtattgt tacccttgga
     6661 attgaaccaa gtagacctga aacggggtat gggtatatag aaatgggaga acgaactact
     6721 gggaatatac caacgtataa aattgctaga tttactgaaa agccaaattt agaagtagct
     6781 aaagatttta tattaaaagg aacgtattta tggaattctg gaatgtttat atttagagca
     6841 gatgttattt tacgagaaat agagaagtat ctgcctaagt tgcatagatc gttaatggaa
     6901 atatataaaa gccttggtga agaaaatgaa gagtcagtga taaaagaaca atatgaaatg
     6961 atcgatggaa tctcaataga ttttggagta atgcaaagaa caagaaaggc atatgttatt
     7021 aaatgtgact ttagttggga tgatatgggc agttttggag ctctaagcag attgttaaac
     7081 acttatagaa ataacaatat atcgaaaaat gtttatgtag atgactgtga aaattgctcg
     7141 atatttggga ataagaattt aataattgga tttggaataa aggatttagt tgttgttgat
     7201 gctggagatg taatacttgt catggataag aacaaagatc aggaaataaa gcatttaatt
     7261 aataaactta atgaaaatca ggaatatagt aaatttctat aattaataag ctgtttcgag
     7321 aatattagga tgagttcgga acggctttat tagttttggt gcttagctat tattgggtga
     7381 tgatacatat aatacttgga caaattatta tataagctat tgaaaattta tactcagagt
     7441 attattataa atgtacacga taaatttaaa ttaaatttta aattatttaa aatggtaaac
     7501 ggttaatatg taaagggaat ttaacagata tgtagaggat gtgatcaagc tttgatgatt
     7561 aatactcaca aaatcatggc tgagaatatt ataaagcgtg caaatacgaa gagtatttat
     7621 ttactcaatg ataaaaggtt tatttggggg aacatcaaac cagattgtgc gcctaaatat
     7681 aaattcaaga agcattattt tgatgaaagt atagaaatga taattgataa aattatatat
     7741 ttatcttcac taacgttaga agatgtgtat tttgatttaa ctgttggtaa atttagtgaa
     7801 gaacttggag taatatgtca ctttctatgt gactttttct gtgcgcctca ttattataga
     7861 tgggaattta agaatactaa ggcagttaaa aagcatatgg cctatgaaaa tagattagca
     7921 aagatagcta aagaatttaa gcccttaggc ataattaata caaatgtaaa gtcaagtaat
     7981 atagaggaat ttatattaga attgcaaaag caatataatg gcgcagtaga atttaagaat
     8041 gatctaacgt tttcgtatta tgtttgtgat agtgtattaa atatgatttt aaataatgta
     8101 tttttaaatg ataagaaagt tagtaaagca atttagctta taaaatatct taaaatagaa
     8161 taaaactatt ttaggatatt ttcatttgaa gaaaaaatat gaaaaataat tgtattatcc
     8221 ttgacataaa attatataag tatggtagaa taataaatta tgatggtaaa tagaattaag
     8281 caccaaaaat gaactgcttt gttaaagaat actaattgtc attaatattt agatggacaa
     8341 tagggattta aagcgagtta taaaaataat taattgttaa gataggagat aagcatggac
     8401 aagagtagaa atatatctat ggcggttatt aaaagattac caaaatatta tagatatctt
     8461 gaagaattga tgaaaaatga tgttgataga atttcttcaa aggaattagg cgaaaaaata
     8521 ggatttactg catcacaaat tcgtcaagat ttaaattgct ttggagattt cggacaacaa
     8581 gggtatggat ataatgttaa ggaattgtat aatcaaatta gctctatttt agggttagat
     8641 aggggatacc aggcagcttt agttggagca ggaaacatcg gacaagcggt atctaattat
     8701 tctagatttg aaaatttagg atttaaaata acatctatat ttgatgcaaa tccaaagtta
     8761 ataggaatga gaattagaga tgtagaaata aaggacatag atgatatgtc aactgttttg
     8821 caagaaagaa aaattgatat aggaataatt tgtgttccaa gaaaaaatgc tcaagtagtt
     8881 gcagatgaat tgataaaagg cggagtaaga gctatttgga attttgcacc tgtagattta
     8941 gttgttccag atcatgtaaa ggtggagaat gttcatttaa gtgaaagttt actgacttta
     9001 atttatttat taaatgaaag tgataattaa aaaatagatg aaagaaaata atagacttga
     9061 taatagtcta ttattttctt ttttttatat ttatatttaa tgaggcctaa cattctaaag
     9121 gtaatatatg tgctggaata ttattgtaaa aggcttttaa gttaggcata tttaactaaa
     9181 tcttatatta aaatataaga ttttattgca aataacttgt gtacgtatta taattttaaa
     9241 tatggtttga tattttttaa acatacttgt tataatatta acaaatgtgt ttgaattata
     9301 ataaaaagtt attcaaataa aattaatatg caagtttgaa ggaggatttt aacatggaat
     9361 taaagaatgt gattcttgaa aaagaaggac atttagctat tgttacaatt aatagaccaa
     9421 aagcactaaa tgcattgaac tctgaaacat taaaggatat tgatgcagtt ttagatgatt
     9481 tagaaaatga tactaatgta tatgccgtta tagtaactgg tgcaggagaa aaatcttttg
     9541 ttgctggagc agatatttca gaaatgaaag atcttaacga agaacaaggt aaagaatttg
     9601 gaattttagg aaacaaagtt ttcagaagat tagaaaaatt ggataagcca gttattgcag
     9661 cagtatcagg atttgctctt ggtggcggat gcgaacttgc tatgtcatgt gatattagaa
     9721 tagcttcagt gaaagctaaa tttggtcaac cagaagctgg tcttggaata actccaggat
     9781 ttggtggaac tcaaagatta gctagaattg tagggcctgg aaaggctaaa gaattaatat
     9841 atacttgtga cttaataaat gctgaagaag catatagaat aggtttagta aacaaaatag
     9901 ttccattaga aagtttaatg gatgaagcta aagctatggc taataaaatt gcagctaatg
     9961 ctccaaaggc agttgcttac tgtaaagatg caattgacag aggaatgcaa gtagatatag
    10021 atgcagctat attaatagaa gcagaagact ttggaaagtg ttttgcaaca gaggatcaaa
    10081 ctgaaggaat gactgcattt ttagaaagaa gagcagaaaa gaatttccaa aataaataat
    10141 attattaatt gtaaataata ttatagaatt ttgctaaaaa tctatttgag atttatatat
    10201 agtttgttat aaagtaggtt taaataacaa ggagggtaat ttaatgaatt ttaagttaac
    10261 tagagaacaa gaattagtgc aacaaatggt tagagaattc gcagtaaatg aagttaaacc
    10321 aatagctgct gaaatcgatg agacagaaag attccctatg gaaaatgttg aaataatggc
    10381 taagttagga atgatgggta tcccattttc taaagaattt ggtggagcag gcggagatgt
    10441 actttcatat ataatcgctg tagaagaatt atcaaaagtt tgtggtacta ctggagttat
    10501 actttcagct catacatcac tatgtgcatc agtaattaac gaaaatggta ctaaagaaca
    10561 aagagaaaaa tatttacctg atctttgtag tggtaagaaa attggtgctt tcggattaac
    10621 tgaaccaggt gctggtacag atgctgcagg acaacaaaca actgctgtat tagaaggtga
    10681 ccattatgta ttaaatggtt caaaaatatt cataacaaat ggtggagttg ctgaaacttt
    10741 cataatcttt gctatgacag ataaatcaaa gggaactaaa ggaatttctg catttatagt
    10801 agaaaaatca ttccctggat tctcaatagg aaaattagaa aataagatgg gtatcagagc
    10861 atcttcaact actgaattag ttatggaaaa ctgtatagtt ccaaaagaaa acctattaag
    10921 tcaagaaggt aagggatttg gaatagcaat gaagactctt gatggaggaa gaattggtat
    10981 agctgctcaa gctttaggta ttgcagaagg agcttttgaa gaagctgtta actacatgaa
    11041 agaaagaaag caatttggta aaccattatc tgcattccaa ggattacaat ggtatattgc
    11101 agaaatggat gttaaaatcc aagctgctaa atacttagta tacttagcag caacaaagaa
    11161 acaagcaggt caaccttact ctttagaggc tgcaagagct aaattatttg ctgcagatgt
    11221 tgcaatggaa gttacaacta aagcagttca aatctttggt ggatatggat acactaagga
    11281 atatccagta gaaagaatga tgagagatgc taagataact gaaatctatg aaggaacttc
    11341 agaagttcaa aagatggtta tcgcaggaag cattttaaga taggaggact tttataatga
    11401 atatagtagt ttgtgtaaaa caagttccag atactacagc agtaaaaata gatcctaaaa
    11461 ctggtacatt aataagagat ggtgttccat caataatgaa cccagaggat aaacatgctt
    11521 tagaaggtgc gttacaatta aaagaacaag ttggaggaaa agttactgta gttagtatgg
    11581 gacttccaat ggctaaagca gttttaagag aagcattatg tatgggagct gatgaagcta
    11641 tcctattaac agatagagct atgggaggag ctgatacttt agctacttca aaagcaatag
    11701 caggtgtaat agcaaaatta gattatgatt tggtatttgc tggaagacaa gcaattgatg
    11761 gagatactgc acaagttggt ccagaaatag ctgaacattt aaatattcct caagtaactt
    11821 atgttcaaga tgttaaagtt gaaggaaaat cactaattgt aaacagagca ttagaagacg
    11881 gacatcaagt aattgaagtt aaaactccat gtttattaac tgcaatcgaa gaattaaatg
    11941 aaacaagata tatgcatgtt gcaaaaatct tcgaaacttc tgatgatgaa atcaaagtta
    12001 tgagtgcagc tgatatagat gtagatgtag ctgaattagg acttaaaggt tcacctacaa
    12061 aggttaagaa gtcaatgact aaagaagtta agggcgcagg agaaatcgta agagaagcac
    12121 ctaaaaatgc agcatactat gttgtaggaa aattaaaaga aaaacactac atctaagata
    12181 ataggagggt aatttattat gaatatagca gattacaaag gcgtttgggt ctttgctgaa
    12241 caaagagaag gccaattaca aaaagtatct ttagaactac ttggtgaagg tagaagaatt
    12301 gctgatgaat taggagtaaa gttaacagct ttattacttg gaaataatat agagacactc
    12361 gctaaaactt tagcagaaca tggtgcagat gaagttttag ttgctgatga taaaaactta
    12421 gaacattata caactgaagg ttacactaaa gttatttgtg acttagcaac tgaaagaaaa
    12481 cctggaatct tatttgtagg agctactttt attggaagag atttaggacc aagaatagct
    12541 gctagattat ctactggatt aactgctgac tgtacatcat tagatgtaga tgttacaaat
    12601 ggagatcttt tagcaacaag accagccttt ggtggtaact taatggctac aattgcatgc
    12661 ccagaccata gaccacaaat ggctacagta agaccaggag tatttgccaa aattactact
    12721 gatccatcta aatgtaatat tgaaaaagtt actgttaaat tagctgattc agatattaga
    12781 acaaaagtat tagaaacaat taaatcaaag aaagatatcg ttgatatagc tgaagctgat
    12841 tttatagttg ctggaggtag aggagttgga aataaagaaa actttacact acttaaagaa
    12901 ctagcagatg ctttaggtgg aactgttgct ggatcaagag cagctgttga aaaaggatgg
    12961 attgatggag cataccaagt tggtcaaact ggtaaaactg ttaaacctca aatatatata
    13021 gcttgtggta tatcaggagc tatccaacac gttgctggta tgcaagattc agatcttata
    13081 attgctgtta ataaggatga ctcagctcca ataatgaaga ttgctgatta tgcaatagtt
    13141 ggagatctta caaaggtagt tccagaatta atcgcacaag ttaaagaaat taagagtgct
    13201 gaataattaa ttaaattaat gaaaaatata atccttagtt aaaatagtgg tattttaact
    13261 aaggatatct ataattatga attttgagga ggaaaagtca atgaaaaaga tttttgtact
    13321 tggagcagga actatgggtg ctggtatcgt tcaagcattc gctcaaaacg gttgtgaagt
    13381 aatcgtaaga gatataaagg atgaatttgt tgatagagga atagctggaa tatctaaagg
    13441 tttagaaaaa ctagtagcaa agggaaaaat gactgaagaa gatagagaag ctatactttc
    13501 aagaatttca ggaacaactg atatgaattt agctgctgac tgcgatttag tagttgaagc
    13561 tgcaatcgaa aacatgaaaa ttaagaaaga aatctttgca gaattagatg gtatttgtaa
    13621 accagaaaca attttagctt caaatacttc atctttatca attactgaag ttgcttcagc
    13681 tacaaagaga gcagataaag ttatcggaat gcatttcttc aacccagctc caataatgaa
    13741 gttagttgaa gttatcagag gagctgcaac ttctcaagaa acttttgata cagttaaaga
    13801 attatcagaa gcaatcggaa aaactccagt agaagttgct gaagcaccag gatttgttgt
    13861 aaacagaatt ttaattccaa tgataaatga agctactttc attttacaag aaggtgtagc
    13921 atctgctgaa gatatagatg cagctatgaa gcttggagct aatcacccaa tgggaccttt
    13981 agcattaggg gatcttgttg gtttagacgt atgtttagct atcatggatg ttttatataa
    14041 tgaaacagga gatagcaaat acagagctag tagtttatta agaaaatatg ttagagctgg
    14101 atggcttgga agaaagtcag gaaaaggatt ctacgattat tctaaatagt aatataaaaa
    14161 atctcaagag aaactattct tttgagattt tttttcaaat gtaaaggatt tttagacttt
    14221 ttatagaaat atatctaata taggaaaaat tctgaaaatt cctatactta tacagatatt
    14281 ttgaggaggg ttattaaaat tatgatgaga tttacattac caagagacat ttattatgga
    14341 aaaggatcac tagagcagtt aaagacttta aaaggtaaaa aagcagtact agtacttggt
    14401 gggggatcaa tgaagaaatt cggtttcgtt gataaagcct tagaatattt aaaagaagct
    14461 ggtatagaag ttaaattaat tgagggtgta gaaccagacc catcagttga gacagtattt
    14521 aaaggtgctg aaacaatgag agagtttggc cctgattgga ttatttcaat gggtggagga
    14581 tcaccaatag atgctgcaaa agctatgtgg atattctatg aatacccaga ctttactttt
    14641 gaaaaagcag tggttccttt tggattacca gagcttagac aaaaagcaaa attcattgca
    14701 attccatcaa caagtggtac agctacagaa gtaacagcat tttctgtaat tacagattat
    14761 aagacagaaa taaagtatcc tttagctgat tttaatataa ctccagatat agctatagtt
    14821 gactcagaac tagcagaaac aatgcctgct acattaacag ctcatacagg tatggatgca
    14881 ttaactcacg ctattgaagc ttatgtagca acattacatt caccatttac agatccatta
    14941 gcattacaag caattgaaat gattcgtgat ttcttactta aatcttatga gggagataaa
    15001 gatgctagag aacaaatgca ttattcacaa tgcctagcag gtatggcatt ctctaatgca
    15061 ttacttggaa taactcatag tatggctcat aagacaggag cagtattcca tatacctcat
    15121 ggatgtgcaa atgctattta tctaccatac gtaattgatt tcaataaaaa gactgcatta
    15181 gatagatatg cttatatagc taagagactt ggattaagtg gtacaactga cgatgaatta
    15241 gtagattcat taacaaactt aattaaagag ttcaataaga agatgtcaat tccacttaca
    15301 ttaaaagaat atggtattga tgaagaagta tttaaagcaa aagttgatat gatttctgag
    15361 agagctattg cagatgcttg tactggatca aatccaagac aattaaataa agatgaaatg
    15421 aagaagatat ttgaatgcat atattatgga aataaggttg atttttaata tctaagctat
    15481 aaaaggtttc gggacaatgt tctgaagcct ttttaatttg aagttttaat aaattttctg
    15541 aattggagga ttatattgga attaagtgat ataatatatt aataaataat catttttgac
    15601 aaggtgggga attaatgtta aaagagatgg tcaaaaaata tagagaagag aaatatgatt
    15661 taaattgtgc agaaagtatt atatatgcag ctaatgaaga atatgatttg aatctttcga
    15721 atgaaacttt gaaagttatg tctggatttg gaggaggaat gggaattggt catatttgtg
    15781 gagttataac tgcctcagta ggtgtgattg gagtgatgtt cactgaaata agcggacata
    15841 aaagtccaag agtaaaagaa atgacacaag aatttataaa taatttgcaa gataaattgg
    15901 gatatattaa atgtgatgat ttaaaaaagg aatatactaa cgtaaaaaaa tgcacactaa
    15961 tgatagaaac aggtgcagaa attttagaag aaattattct caaagaaaag cagaataaaa
    16021 tattatagat tttcaaggga gaaagatata aatggattat aagtcagtaa aatttcatga
    16081 taattatata gtgatagagg aggttaaaaa ttttaaatta aagcatatat ttgaatgtgg
    16141 tcaaattttt agatttgagg aaattgcaga aggtcactat attgtaattg catttggaaa
    16201 attgattgaa gttaaagagg aaggtgcaaa tataataata tataatgcaa cagaagagga
    16261 agttaatgaa atttggatta aatattttga tttagatagg gactactcag agataaagca
    16321 agaactttca aaagatccgt tacttaaaca aagtatagaa tttggatatg gagtgagagt
    16381 tttaaatcaa gatccttttg aaatgttaat cagcttcata atttctgcaa gaaataatat
    16441 accttcaata aaaaagactg tgaataaaat atcaaacaaa tggggaaaag aaattatata
    16501 taaagaaaaa acatattacg catttccaag cataaatgaa attaaagatg ctacattgga
    16561 ggaaatacaa gaaacaggag catcgtttag aagtaaatac atattagata cgattaaaaa
    16621 tgtttatgca tctgacaagg tgatggatga ctcgaattta gataaaaaaa atagttatct
    16681 aaaatataac ttagattata ttaaaaattt gaaggatgat gagtgtcatg aggctcttca
    16741 agaattcaaa ggagtaggag ctaaagtggc tgattgtatt atgctatttt ctatgggtaa
    16801 aacttcggca tttccagtgg atgtctgggt taagcgtgca atgattcatt tttatggtgc
    16861 agaaaattct tcattaaaca aaattagaat atttggaaga aatgagtttg gtaagctttc
    16921 tggatttgca caacaatatt tattttatta tgcaagagaa aacaaaattg aggtttaaga
    16981 ttaatatttc ccaaggtgtg atattttagt ttattagtaa ataaatataa atagagaata
    17041 agtcaactaa actagagata ttctgttatg aataaggaaa atccttatat acaaaattaa
    17101 tattaaatca ataagtgaat tgatttaata ttctgcagaa tttaaagtgt gttgacttat
    17161 tattttttat atattaatat aggcaaaaaa ttactgttag agcggaaaaa tcagaaaatt
    17221 taaacttata tgatacttgt tatattttta acaagtatgt gttataatta tgccgtgcta
    17281 ttaaatataa gattaaaatt acttttggga gagtgtatat taatgtttca atttgaaaat
    17341 cgacttttaa agctaaagca tgaagttctt actagagttg tagtgttagc aaaagaaaac
    17401 aaactttgta aagaggagtt agaaaaaatt ccttttgaaa tgattgtagg agatgaacct
    17461 aattatcgag aaactgttga tagagaaaga aatatagtac tggaaagagc aaagcttgct
    17521 gcaggttata tgccaaatgg caaaaatgga caagaactag ttgagataga tgaagaaaaa
    17581 cagatattgt atgttataaa ggaagcatgt gacagatgcc caacaaataa gttccaagtt
    17641 actgattctt gcagaaattg tgttgcacac aagtgtcaaa gtgtatgtaa ttttggggca
    17701 atttcatatg ttaatggaaa agcatatatt gatccagata aatgtaaaga atgtggaatg
    17761 tgtaataagg tatgtcctta tgatgctatt gcagaagata tgagaccttg taaaaaagca
    17821 tgtccaacag gagccttaag ctataatgct gacgatttaa gagctgagat tactgaaagt
    17881 aaatgcgtaa attgtggtgc gtgtatgtct gaatgtccat ttggtgctat agaagataaa
    17941 agttcattag ttagagttgt taatagatta atggaaaaag aaaatattta tgctatagtt
    18001 gcaccagcga taacaggtga atttggcgca aagacaacat atggacaagt aaaaaatgca
    18061 attaaagcat tagggtttac agatatggta gaagtagcat gcggtgcaga tgcagttact
    18121 gtacatgaaa gtacagaatt tgtagagaga atggaaaaag gggatagcta catgacaaac
    18181 tcatgttgtc caggctttct aagttatatt gaaaaaatga tgccagatca agctgaaaga
    18241 atttcaggaa ctgtttctcc tatggtagct acgggaagat atataaaagc aaagcataaa
    18301 gatgctaaag ttgtatttat aggaccttgt actgctaaga aaagtgaagt attgattgaa
    18361 tcaataaagg atgctgttga ttatgcatta acttttgaag aattaattgc tttatttgat
    18421 gcatttgaaa tagatcctga aaaatgtgaa gatatagtag ttgatcaagc atcaatcttt
    18481 ggtagaaatt ttgctgtagg tggtggttta actgcagcga tagaaaactt catccaagaa
    18541 aaaggtgtgg aaattgaatt caaacctgtt aaagtttcag gtggagcaga aataaagaaa
    18601 actatgacta tggctaaagt aggaaaatta ccaggaaatt tcattgaagg aatgatgtgt
    18661 gaaggcggat gtataaatgg agctgcaaaa atagcacctg ttatgaaagc aaaggcacct
    18721 ttcacaaaaa taaatcaaca aacaactatt aaaactgtat tatcaaataa ggcattagaa
    18781 gagtatcata atattgactt agaaagatag tttgtttttg gaaaaatata tatttcttat
    18841 tatagcttaa atgtagatat aaactctact caggagtatt ttcttgagta gagtttttca
    18901 ttataaataa aaagtaagaa aaattgagaa agtttaagca aattaaatat attttgagat
    18961 aataggtaat attcgcttaa aaatcgggta taatattaga agtaatgttt gaattatatg
    19021 gatataaagg atattataaa tatgttagca ctcgacagta acgagtgcta acagaaaaaa
    19081 gcaacaataa taacataatt attttaagga gggtttttca tgaaaattaa accacttggt
    19141 gaaagagttg taatcaaaaa attagaggca gaagaaaaga ctaaaagtgg aatagtctta
    19201 actggtactg caaaagaaag accacaagaa gcagaagtgg ttgcagtggg tcctggagct
    19261 gtcgtagacg gaaatagagt acctatggaa gtaaaagttg gagataaggt tttatactct
    19321 aaatatgcag gatcagaagt taaagttgat ggtgaagaat atactatttt aaaacaagat
    19381 gacatattag caatagtaga ataattgaga gtgcattgct aaataatttt aatttaagaa
    19441 gatagaaaga tataaataac atacaaaaaa ggagagtgtt atataaatgg ctaagatgtt
    19501 aaaattcggt gaagaagcaa gaagatctat gcaaataggt gtagataaat tagcagatac
    19561 agttaaggtt actttaggac ctaaaggtag aaatgttgta ttagataaga aatttggagc
    19621 accattaatt acaaatgatg gtgtgtcaat tgcaagagaa atagaactag aagatccata
    19681 tgaaaatatg ggagctcaat tagttaaaga agttgcgaca aagactaatg atgtagcagg
    19741 agatggaact acaactgcaa ctttgttagc acaagcaata atcagagaag gattaaaaaa
    19801 tgtaacagct ggagctaatc ctattttaat cagaactggt attaaaatgg ctgtagaaaa
    19861 agctgttgaa gaaattaaaa agatttctaa gcaagtagat ggaaaagaag atatcgctag
    19921 agttgctgca atttcagctg ctgatgaaga agttggtaag ttaattgcag atgctatgga
    19981 aaaagtagga aatgaaggcg ttattacaat agaagaatct aaatcaatgg gaactgaatt
    20041 agatgtagtt gagggaatgc aatttgatag aggatatgta tcaccttata tggctacaga
    20101 tactgaaaaa atggaagcag ttttagaaaa tccatatata ttaataactg ataagaagat
    20161 ttcaaatatt caagaaatct taccagtgct tgaacaaatc gttcaatcag gtaaaaaatt
    20221 attaattatt gctgaagaca ttgaaggaga agcaatggct acattagtag ttaataaatt
    20281 aagaggaaca ttcacttgtg tagctgttaa agcaccaggc tttggagata gaagaaaaga
    20341 aatgttacaa gatattgcaa cattaactgg tggaactgtt atagctgaag agttaggaag
    20401 agaattaaaa gatgttacta ttgatatgtt aggtacagct gatagtgtta aggttaataa
    20461 agaaaacact gttatagtta atggtaaggg tgattctaat ggaataaaag aaagaattaa
    20521 ccaaatcaaa gttcaaattg aagaaacaac ttcagaattt gataaagaaa aattacaaga
    20581 aagattagct aagttagcag gtggagttgc agtaattaaa gttggtgcag caactgaaac
    20641 agaacttaag gaaaagaaac ttagaattga agatgcttta aatgcaacaa aagcagcagt
    20701 tgaagaagga atagtagctg gtggtggaac agcttatgtt aatgtaatta atgaagtagc
    20761 aaaattaact tcagatgttg cagatactca agttggaata agcataattg taaaagcatt
    20821 agaagaacca gtaagacaaa tagcagctaa tgcaggagtt gaaggttcag taataattga
    20881 aaaagttaaa aatagcgaac caggtatagg atatgatgca ttacatgatc aatatatcaa
    20941 tatgattaaa ggtggaatag tagacccgac taaggttact agatctgctc ttcaaaatgc
    21001 agcatctgta gcttcaacat tcctaacaac agaagcagca gtagctgata tcccatctaa
    21061 agaaccagca atgccaggtg ctccaggaat gggaatggac ggaatgtact aaaattaaaa
    21121 atgacatatg ttaatgaagt aattagagga gtaattttac tcctcttttt gatgtgagaa
    21181 atataatggt tttatttatt ataattgtat aaattaatga agaagtagac ataatttaaa
    21241 ctaaaactga gaaaaggagt tttggtttaa gatgataaag cacggtagca agattgaaat
    21301 aaaacatgta tattataatg atagaaaaag aaaagaagga tttactttaa tagagatgat
    21361 agctgtaatt gctatgatag gaattttggc tgcagcactt ttacccaaaa taggtggtta
    21421 tataaaacag gctaaaaaaa caaaaatact agatcaatgc agaaaagttg ttatggcagt
    21481 tgattcctat aatcttacaa gtaatacacc tgtagaacaa actgctacca ttgatgacgt
    21541 tgaaaaggta gctggagttg aaacatattt agatggagtt tcgttaagta atttagatac
    21601 tgaaaagaca aatatcaaga aatgttatga tattgtggcg ggagaagaat ttgatataga
    21661 taatgaagaa aagttaataa attaagatat tatgcaataa aaacgattat atataaatta
    21721 taatttagaa aaaatgcaat tttaatttca aatttgttga ctttagagta cacatacatt
    21781 ataataattt taattcaaaa acataaaata tttaaaagct tatatatacc ttgaatatgg
    21841 caaggagtat ctaccggaaa ccgcaaattt ctgactataa gtgatattgg tataggataa
    21901 gactaaggtt ttattggcat attaacatca cttttgaggt taatgtgctt tttttatata
    21961 taaaaataat ataaaaatgc aagaaaaaaa tcattaataa tttaaaatga aataaataaa
    22021 tcaaaaactg gggaggattc ataatggcaa aaataattaa gacagcatat acttttgatg
    22081 atgtattatt agtacctaac aaatctgaaa tattaccaag ggaagtaagt acaaagacaa
    22141 agttaactaa gacaatagag ttaaatattc ctttaatgag tgcaggaatg gacacagtaa
    22201 ctgaatcaaa aatggcgatt gctatggcaa gagaaggcgg aatcggaatt atacataaaa
    22261 atatgactat cgaacaacaa gccaaagaag tagatagagt taagagacaa gaaaatggtg
    22321 ttattacaga tcctatatat ttatcacaag atcaccttat tcaagatgca gaaaatttaa
    22381 tggctcaata tagaatatca ggagttccta taactactga agaaggaaaa ttaatcggaa
    22441 taataactaa tagagatata atttttgaaa cagattttca aagaaaaatt tcagaagtaa
    22501 tgactaaaga aaatttaata actgcatctg aaagtactac tgtagaagaa gctaaagaaa
    22561 tattaaaaaa acataaagtt gaaaaattac ctttggttga tgagaacgga atcttaaagg
    22621 gattaatcac aatgaaagat atcgaaaagg tgaggaaatt cccaaatgca gctaaggata
    22681 gtaaaggtag attattatgt ggggcagcag taggggttac tggaaacatg atggaaagaa
    22741 ttgatgcttt ggttaaagcg caagttgatg ttgttacact tgacacagct cacggacatt
    22801 caaagggtgt tttagatgca gtaacacaaa ttaagaaggc ttacccagaa cttcaagtaa
    22861 tagcaggaaa tattgcaacg gctgaagcta cagaagattt aataaaagct ggagctgatt
    22921 gtgttaaagt tggtattgga ccaggatcaa tttgtactac aagagttgta gcaggagttg
    22981 gagttcctca attaacagca gttatggatt gtgcggaagt tggtagaaag tacggaattc
    23041 ctgtaattgc agatggtgga cttaaatatt caggagatat agttaaggca ttagctgctg
    23101 gagcttctgt agcaatgatg gggtcattat ttgcaggttg tgatgaagca ccaggagaaa
    23161 tggaaatata tcaaggaaga agttacaagg tttatagagg aatgggttct ctagcggcta
    23221 tggaatgcgg atcaaaggat agatatttcc aagaaggaaa taaaaagcta gttccagaag
    23281 gcgttgaagg aagagtagca tataaaggtc ttgtttcaga tactatattc caattattgg
    23341 gcggaattaa atcaggatta ggatatttag gatcgaaaaa ctttgatatt ttatatgaaa
    23401 cagctaattt tgtagttcaa acagcttcag gtcaaagaga aagtcatcca catgacatta
    23461 atattactaa agaagcacca aattatagtg taggacaata a
//
