LOCUS       c00026_NZ_JPMD..       14442 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_JPMD01000026.1 Clostridium sulfidigenes strain 113A c26, whole
            genome shotgun sequence.
ACCESSION   NZ_JPMD01000026
VERSION     NZ_JPMD01000026
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 00:17:32
            Original ID  :: NZ_JPMD01000026.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14442
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14442
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[215:4442]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      216..4442
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14442
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14442
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             216..3122
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_1"
                     /sec_met_domain="HGD-D (E-value: 3.2e-14, bitscore: 45.3,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 4.5e-39, bitscore:
                     126.5, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIGIDVGSTTIKSVVLNNFGEVIYQSYERHYCKIKEKTSELLKK
                     IRDKYPREKSMELSISGSAAMGMAEKWKVPFVQEVYATRIAATTLEDDVDVIIELGGED
                     AKILFLKDGMEVRMNGSCAGGTGAFIDQMATLLNMSLEEMNEAAKDYKKIYTIASRCGV
                     FAKSDIQPLLNQGVVKSDLSASIFFAVVNQTIAGLAQGRVIKGNVLYLGGPLSFNSELR
                     KAFDKTLNLTGKCPDNSLYYVALGAAYYASEKIDIDNLIITLNNYREDETYSMAPPLFK
                     TKEEYDEFKLRHEKSKVLIKDEIDAASPITIGIDSGSTTIKIVAINENKEIVSSIYRPN
                     SGNAVEVVKEYLENIYNTYPKVKISAVAATGYGEQLIKNAFKVDYGMVETVAHFTAAKH
                     FMNNVDFIIDIGGQDIKCFKIHNGAIDNIFLNEACSSGCGSFLQTFANALGYSVEEFAN
                     LGLFSKNPVDLGSRCTVFMNSSVKQVQKDGATIEDISAGLSVSVVKNALYKVIRASNAE
                     SLGKNIVVQGGTFLNDAVLRAFEQELNVQVLRPTISGLMGAYGAALYAHGKNNDKSTIL
                     NKSELENFNHEVKMTNCGLCNNHCRLTINTFGESRKYIGGNRCDRPISNKNHGEVSNIY
                     EYKRSLLDSYPNISGKRGKIGIPMGLNMYELYPFWYKFFTTLQFEVEKSEPSSREIYLK
                     GQTTIPSDTVCFPAKLIHGHVQSLIDGGVDTIFYPCMTYNIQDSSADNCYNCPVVAYYS
                     EVIQGNMPDVSKVTYIYDYIGIHRPKDFPKKMHNILVKYFMDISLKEVKEATTLAYKEY
                     DRYLKKVRIKGEEIIEKAEKEGKDIIVLAGRPYHIDSEINHGIDKYINSYGAAVISEDV
                     ISHNVDKVDLQVLNQWTYHARLYKAAKYIADKPNMNLVQLVSFGCGVDAITTDEVREIL
                     EESNKIYTQIKIDEITNLGAIQIRLRSLFAAIHQGEGE"
     CDS             3126..4442
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_2"
                     /sec_met_domain="HGD-D (E-value: 4.5e-26, bitscore: 84.3,
                     seeds: 370, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNENKVTFTKEMSKDYTILMPMMAPIHFEILKNVFLNSKYHIEL
                     LTNKGESVVQTGLKYVHNDTCYPALLVIGQMIDALNSGKYDINKTALIITQTGGGCRAS
                     NYIYLLRKALKKAGYGQVPVISFNLAGMEKDSGFKITLPMVHKMLSGVIYGDLLMHLRN
                     QVRPYEISKGESDKVIKKWIEELTLQFKNNKAYSLKKIKTNMDNITKDFANIKIEKTPK
                     VKVGIVGEIYIKYASLGNNDLEAFLATQNCEVMIPGILGFVFYCTDERIDNINLYGGSK
                     VVKFIVQKFMNYLLKIESLLISSVKENSDFIPPSSFKETKKLAKGVVGYGNNMGEGWLL
                     TAEMLELNNLGYKNIICTQPFGCLPNHIVGKGMVRKIKNIHHDVNIVPIDYDPGATRVN
                     QENRIKLMLAIAKEQLDHKELNINPKDINSDIDKEIALV"
     CDS             4835..5032
                     /locus_tag="ctg26_3"
                     /transl_table=11
                     /translation="MNLKSEHHSLLNNNPGTIERDLGREVRNKVSDNELKSEANTKRNK
                     ESIENSIEKGEGYLYNTLED"
     CDS             5215..5385
                     /locus_tag="ctg26_4"
                     /transl_table=11
                     /translation="MVKIDEMDKRVCEMRQNLQKLISEKTNLLDPEVIIASQKLDVVLN
                     EYHAILRKILE"
     CDS             5569..6537
                     /locus_tag="ctg26_5"
                     /transl_table=11
                     /translation="VSGNQGKSKVKSGGKILIPIIIMLFVIYEARSIFKEIDINQVLDI
                     LRNIPNTYLVIFLISTIISISFLCFYDVVLADHYRYNINKFKVFVVAWIAHSFNDIIGF
                     GGLTGATLRTVLFKDENIDTKDMINFNMILIPTTIVGLSVMCYLGVLDVFKIYPLLHSQ
                     KWLWIVILIFCAFLPIYYFLDRFTWLSNKLEKFNLYFEGSINLKVRLTLLSTCEWIVRS
                     MMFFTIAKYFKGDASFVSVTGVNILACIAALISFIPGGVGSFDLVAIIGLKTLGFSPNS
                     ALSITLLFRLYYFIIPWIIGVILWVGRVVLRSNKLGNHIRE"
     CDS             6572..7252
                     /locus_tag="ctg26_6"
                     /transl_table=11
                     /translation="MKDILKLLQNNFLFKGIDSENLKKIYEETRYHINKYDKGEIIAHE
                     EEECSTIGLILEGTIELQRIYPSGKYIVLNKLTLGDVFGEAIIFSKQENYPATVIALNQ
                     CSILYIDKVDMLELFSREKRILENFLELLSNKVLMLNSKIKNISFKNIRHRVINYILET
                     MKLQKNSTIKLKESKESIAAALGIPRPSLSRELINLRDMGYIDFDRSNIKILDIEALEE
                     EMFN"
     CDS             7461..9101
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Prismane"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_7"
                     /sec_met_domain="Prismane (E-value: 2.5e-185, bitscore:
                     608.9, seeds: 159, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENKMFCFQCQEAAGCSGCTVRGVCGKTPDLAKLQDLLIYSSRGL
                     SEVATRAREEGVTVSNIINRAVTMNLFTTITNANFDDAVFYKMVKETLNLKEELLSKLS
                     NKEDLSDAALWTAKTEAEMDSKAGLVGVLSTDNEDIRSLREMITYGLKGLAAYVKHANA
                     LGYDDEAICAFMQKALAATADNKITIDEYIALTLETGKVGVDGMALLDKANTESYGHPE
                     ITKVNIGVSNKPGILVSGHDLKDLEQLLIQTEGTGVDVYTHSEMLPAHYYPAFKKYSHF
                     IGNYGNAWWKQTEEFESFNGPILMTTNCIVPPKDSYKARVFTTGAAGYTGCTHIAADEK
                     GNKDFSALIELAKTCEAPIEIEHGEIIGGFAHNQVLALADKIVEAVKTGAIKKFFVMAG
                     CDGRQKKREYYTDFAKALPQDTVILTAGCAKYKYNKLDLGDIGGIPRVLDAGQCNDSYS
                     LALIALKLKEVFELEDINELPIAFNIAWYEQKAVIVLLSLLHLGVKNIHLGPTLPAFLS
                     PNVANVLVENFGIGGITNVEDDMKMFMEM"
     CDS             complement(9202..9528)
                     /locus_tag="ctg26_8"
                     /transl_table=11
                     /translation="MSVYQITYYIAETHNHECDHDHQHDENCNHDHHHHHSNLPRKIKS
                     LGAWANIMPTTFLLHTEMNSKDIKLALDEVKEDNEIFFISQVTLDNDGSMHPGALAWIE
                     SRLK"
     CDS             10175..11422
                     /locus_tag="ctg26_9"
                     /transl_table=11
                     /translation="MERKGIVVGININNENGFEESMVELKNLCMACDIEAIGELVQNSK
                     QINKAHYIGSGKLDELKSLVNSEEVDIVIFNNELSSSQLRNIEKAIECEVIDRTALILS
                     IFAERAKTREAKLQVEVARLQYLLPRLIGANENLGRQSGGVGTKNKGAGEKKLELDRRK
                     IEAKIAALNKELEELKHQRETQRNLRRKSSVPQIALVGYTNAGKSSIMNSMIDTFKDSE
                     EKKVFEKDMLFATLETSIRSIKLDDNKKFLLSDTVGFVSNLPHNLIKAFRSTLEEVCEA
                     DLLLHVVDISNPDYKHHLKVTNETLKEIGAESVPMIYVYNKIDLVDDYLTEKNGVYISA
                     KKNLGIDKLVETISTKVFNNYINCNMFIPYDKGNLLSYLNDNARVIDRKYRNDGAELSI
                     ECSNIDYEKYREYVIG"
     CDS             11974..13308
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Branch_AA_trans"
                     /gene_functions="transport (smcogs)
                     SMCOG1000:Branched-chain amino acid transport protein
                     (Score: 543.7; E-value: 1.1e-165)"
                     /gene_kind="transport"
                     /locus_tag="ctg26_10"
                     /sec_met_domain="Branch_AA_trans (E-value: 1e-165,
                     bitscore: 543.7, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLSKKDLVLISLMLFSLFFGAGNLIFPPFLGQLAGGATWISMA
                     GFFITAVGFPVLGVVAVAKSGGLHNLAKRVNPLFAGVFTVLIYLSIGPCLGIPRAGSLP
                     FEMAVAPYLPESISKIWALFIFTLIFFSVAYWLSLTPAKLVDRMGKFLTPILLVLISLI
                     FIASIFRPLGSYGVATEEYVNSPFVKGFLDGYLTMDTIAALNFGIVIALAIKSKGIKDE
                     KAIISTSVKAGVGAGGLLIVVYSILAHLGATSGGRFGTTENGAQTLTNIMTYIFGKPGA
                     VLLAVIFTLACLTTCVGLITSCSQYFSALNSKLSYKNWVRILSLSSMILANMGLTKILA
                     ISVPVLNAIYPIAIMLIVLAMLDKFFNGSTVVYGLTILFTGIVSVADALGQVGIQWNFI
                     VNLFSKLPLYSKGLGWVVPALIGIVLGTVYKLVEEKISYSKVSEL"
     CDS             13456..14223
                     /locus_tag="ctg26_11"
                     /transl_table=11
                     /translation="MEYTVQNLGKLAGISTRTLRYYDEIGILKPARINSSGYRIYGQAE
                     LDRLQQILFYRELGVSLIDIKNIINEPSFDGINALIEHRLKLLEKRKQIDLLIANVEKT
                     IANKKGGIKMSNKEKFEGFKQKLIDKNEKKYGKEIREKYGDEEVNKSNAKVKAMSEKEY
                     EEVTNLAEEIMNTLSAAFKTGNPAGELAQKTAELHRKWIEYYWSSYSKEAHAGLAQMYV
                     DDERFTAYYDAKQPGMAAFLRDAIFIYTGTDKY"
ORIGIN
        1 atatttatta aattgaaaaa ctataatttc taaagataga gaaatagttg tttacagtat
       61 gttaaataat agttaaatat atgttattta gtaaataata tggtataata tggtgtttag
      121 ataatatgta gaagatttat aaaactaaat ctttaattgt tatttttaag agggtaaaag
      181 ctatatagta tggcatttat ttaggaggat ttactatgaa aataggaatt gatgtgggct
      241 caaccacaat taaatctgtt gttttaaata actttggaga agttatttat caatcatatg
      301 aacgtcatta ttgtaaaata aaagaaaaga cttcagaact gctaaagaaa attagagaca
      361 agtatccaag agagaagtcc atggaactaa gcatttctgg atctgctgct atgggcatgg
      421 ccgaaaaatg gaaggtaccc tttgtacaag aggtttatgc aacaaggatt gctgcaacta
      481 ctttagaaga tgatgtggat gttatcattg aattaggggg agaagatgct aaaatactat
      541 ttttaaagga tggtatggaa gtaaggatga atggctcatg tgcaggtgga acaggagcat
      601 ttatagacca aatggctact ttgttaaata tgtccttaga agaaatgaat gaggctgcta
      661 aggattataa aaagatttat actattgcct ctagatgtgg agtttttgct aagtcagata
      721 ttcaacctct tttaaatcaa ggagttgtaa aaagtgattt atcagcaagt attttctttg
      781 ctgttgtaaa tcaaactatt gcaggattag ctcaaggtag agttataaaa ggtaatgtat
      841 tatatcttgg aggaccacta agctttaact cagaattgag aaaagccttt gacaaaactt
      901 taaatttaac aggaaagtgt ccagataact cactatatta tgtagcttta ggggcagcct
      961 attatgctag tgaaaagata gatatagata acttgattat tactttaaat aattatcgtg
     1021 aagatgaaac ttattctatg gcaccaccac tatttaaaac aaaagaagag tatgatgaat
     1081 ttaagcttag acatgagaaa agtaaggttc ttatcaagga tgaaattgat gctgcatcac
     1141 caataacaat aggaatagat tctggttcta caactataaa aattgttgct attaatgaaa
     1201 ataaagaaat tgtatcttca atttatagac ctaatagtgg aaatgctgta gaggtagtta
     1261 aggaatactt agaaaatata tataacacat atccaaaagt taaaatttca gcagttgcag
     1321 caacaggata tggtgaacaa ttaataaaaa atgcctttaa ggtagattat ggtatggtag
     1381 aaacggtagc tcattttact gcagccaaac attttatgaa taatgttgac tttattattg
     1441 atataggagg acaagatata aaatgtttta aaatacataa tggagctata gataatatat
     1501 ttttaaatga agcttgttca tcaggttgtg gctctttctt gcagaccttt gctaatgcat
     1561 taggatattc agttgaagaa tttgctaact taggattatt ctctaaaaat ccagtagatt
     1621 taggttctag atgcactgta tttatgaatt cttctgtaaa gcaggtgcag aaggatggag
     1681 ctaccataga agatatatca gcaggattat ctgttagtgt agttaaaaat gcactatata
     1741 aagtaattcg tgccagtaat gcagagtctc taggaaaaaa tattgtagtt caaggaggaa
     1801 ctttcctaaa tgatgctgta cttcgtgcct ttgaacaaga attaaatgta caagtcctta
     1861 gacctacaat ttctgggctt atgggtgctt atggagcagc tttgtatgct catggaaaaa
     1921 ataatgataa aagtactatt cttaataaga gtgaattaga gaattttaat catgaagtaa
     1981 aaatgactaa ctgtgggctt tgcaataatc attgtagatt aactataaat acctttggag
     2041 aaagtagaaa gtatattggt ggaaatcgat gtgatagacc tataagtaat aaaaatcatg
     2101 gagaagtgtc caacatatat gagtataaga gaagcttact agatagttat cctaatattt
     2161 caggtaaaag aggaaaaatt ggaattccta tgggattaaa catgtatgaa ttatacccat
     2221 tttggtataa attttttaca accttacagt ttgaagtaga aaaatctgaa ccatcttcaa
     2281 gagaaattta tcttaaaggg caaacaacta taccatcaga tacagtatgc tttccagcaa
     2341 agctaattca cggacatgta cagtcactaa tagatggtgg agtagataca attttttatc
     2401 catgcatgac ctataatata caagatagtt cagctgataa ctgttataac tgcccagtag
     2461 ttgcatatta ctctgaagta attcaaggaa atatgccaga tgtttcaaag gtaacctata
     2521 tttatgatta tataggaatt catagaccta aggattttcc aaagaagatg cataacatat
     2581 tggtgaaata ttttatggac atatctttaa aagaagttaa ggaagcaact actcttgctt
     2641 acaaagaata tgatagatat ttaaaaaaag taaggataaa gggtgaagaa attattgaga
     2701 aagcagaaaa ggaggggaaa gatataattg tccttgctgg tagaccttat catatagata
     2761 gtgaaattaa tcatggaatt gataagtata ttaatagcta tggagctgca gttatatctg
     2821 aagatgtgat ttctcataat gtagataagg tagaccttca ggtgttaaat caatggacat
     2881 atcatgctag attatataag gcggctaagt atatagcaga caagcctaac atgaatttag
     2941 ttcagttagt ttcctttggt tgtggtgtgg atgcaataac taccgatgag gtaagagaaa
     3001 ttttagaaga gtcaaataag atatacaccc aaattaagat agatgaaatt actaatttag
     3061 gagcgataca aataagactt cgtagtttat ttgcagcaat ccatcaaggg gagggtgaat
     3121 aagtaatgga taatgaaaat aaagtaacct ttactaaaga aatgagtaaa gattatacta
     3181 tattaatgcc tatgatggca cccatacatt ttgaaatttt aaaaaatgta ttcctaaata
     3241 gtaaatatca catagaacta ttaactaata aaggtgaatc agtagtacaa acaggactaa
     3301 aatatgttca taacgatact tgctatccag ctttactggt tataggtcaa atgatagatg
     3361 ctttaaatag tggaaagtat gatattaata aaacagcttt aattatcact caaactggag
     3421 gaggatgcag agcatcaaac tatatatact tacttagaaa ggcattaaaa aaggctggat
     3481 atggacaggt tcctgttatt tcttttaatt tagccggaat ggaaaaagat agtggcttta
     3541 aaataacatt gcctatggtt cataaaatgt tatcaggagt catttatgga gatcttttga
     3601 tgcatttgag aaatcaagtg agaccttatg aaataagtaa aggtgaaagt gataaagtaa
     3661 taaaaaaatg gattgaagag ttaactttgc aatttaaaaa taataaggct tattctctaa
     3721 aaaaaattaa gaccaatatg gataacataa caaaagactt tgcaaatata aaaattgaaa
     3781 aaactcctaa agtaaaagtg ggtatagtgg gagagatata tattaaatat gcaagcttag
     3841 ggaataatga tttagaagca tttttagcta cacagaattg tgaagttatg ataccaggaa
     3901 ttcttggatt tgtattttat tgtacagatg aaagaataga caatataaat ctttatggtg
     3961 gaagtaaggt agttaagttt attgttcaaa aatttatgaa ttacctattg aaaattgaga
     4021 gtttacttat atcttcagta aaggaaaatt cagattttat accaccatca tcctttaaag
     4081 aaactaaaaa gttagcaaag ggtgtagttg gatatggtaa taatatggga gagggatggc
     4141 ttcttacagc agaaatgtta gagttgaata atttaggata taaaaatatt atatgcactc
     4201 aaccctttgg atgtttgcca aatcatatag taggtaaggg aatggtacga aaaataaaaa
     4261 acattcatca tgatgttaat atcgtaccta tagattatga ccctggtgct actagagtaa
     4321 atcaggaaaa tagaattaaa cttatgcttg ccattgcaaa ggaacaacta gatcataagg
     4381 aacttaatat caatcctaaa gatattaata gtgatataga taaggaaatt gcattagtgt
     4441 aaaactacaa attttaaaaa agttattcaa ttataaaact gaatagatat taagaaatct
     4501 attgtataat aaaataattc ataatatgga attaaattaa attgtatgat attattaaca
     4561 ggtagagaaa ataagtaatc aaactgttaa taaggcttgt tggtcaagtg gtcaagacgc
     4621 caccctctca cggtggaaac aggggttcga tccccctaca ggctaccata ttgtattgaa
     4681 ggatttagct attatagcta agtcctttaa ttttttatat tgaaaataat ttatgaagaa
     4741 tagataataa ttgagttttt ccattatata aataagtata tgaatcttac ttaatgaaga
     4801 taataatata aattacattt taggaggtaa gattatgaat ttaaaaagtg aacatcattc
     4861 tttattaaat aataatccag gaactataga aagagatctt ggaagggaag taagaaataa
     4921 ggttagtgat aatgaattaa agagtgaagc taatacaaag aggaacaagg agtctataga
     4981 aaattccata gaaaagggag aaggatatct ttataacaca ttagaagatt aatatattga
     5041 aattattata tctaggggaa agcaaattta ctttataaat aagtagattt gctttatttg
     5101 ttttaacatt tataacccta taaaataatt aattttaaat aagtgttaaa attaacttta
     5161 tattcaagtt attaaccctc ttattgctat aattatagcg aaaggagggg cgatatggta
     5221 aaaattgatg aaatggataa aagggtttgt gaaatgagac aaaatttaca aaagttaatt
     5281 agtgaaaaaa ctaatttact agatccagaa gtaatcatcg caagccaaaa actcgatgtg
     5341 gttttaaatg agtatcatgc aatactaaga aaaatcctcg agtaaaacaa aagttggaga
     5401 gatctaaagt ctctcctcca aggagataaa ataaataaaa gtatctatat aatctaaaat
     5461 atagatttta atgcatataa gtagtagaat ggtaatatgt tgaaaatata agctaagtaa
     5521 aatatatata ttttatttag cttttaaatt ggattagggg gacataatgt gagtggtaat
     5581 caaggaaaaa gcaaagtgaa aagtggagga aagattttaa ttccaataat aattatgctt
     5641 tttgtaattt atgaagctag gagtatattc aaggagatag atataaatca ggttctagat
     5701 atattaagaa atatacctaa tacatatctt gtaatattct taatatctac aattatatct
     5761 atatcgtttt tatgctttta tgatgtagta ctagctgatc attatagata caatataaat
     5821 aagtttaagg tatttgtagt tgcatggatt gctcatagct ttaatgacat aatagggttt
     5881 ggagggctta caggagctac acttagaact gttttattta aagatgaaaa tattgatact
     5941 aaggacatga taaattttaa tatgatacta atacctacaa ctatagtggg cttatcagtt
     6001 atgtgctatt taggtgtatt agacgtattt aaaatatatc cattattaca tagccaaaag
     6061 tggctttgga tagtaatatt aatattttgt gcttttctac ctatatatta ttttttagat
     6121 aggttcactt ggttaagcaa taaacttgaa aaatttaatt tatactttga aggaagcata
     6181 aatttaaagg tcagattaac ccttctatct acctgtgagt ggatagtgag aagtatgatg
     6241 ttttttacca tagctaaata ttttaaaggt gatgcaagct ttgtatcggt tacaggagta
     6301 aatatattag catgtattgc tgcacttata agctttatac caggaggtgt agggtccttt
     6361 gatttagtag ctataatagg actaaagact ctggggtttt cgcctaactc agctttatct
     6421 ataacgcttt tatttagact atattacttt ataatacctt ggattattgg agtaattcta
     6481 tgggtaggaa gagtagtatt aaggtcaaat aaattaggta atcatatacg agaataaaat
     6541 aagttaatac aataaaagaa gaggatgaat aatgaaagat atattaaaat tactacaaaa
     6601 caatttcctt tttaaaggaa ttgattctga gaatctaaaa aaaatttatg aggaaacaag
     6661 atatcatatt aataaatatg acaaagggga aattattgcc catgaagaag aagaatgcag
     6721 tactatagga cttatattag aaggaaccat tgaacttcaa aggatatatc caagtggtaa
     6781 atatatagtt ttaaataaac ttacccttgg tgatgtattt ggagaagcca taatattttc
     6841 aaagcaggag aactatccag ctacagttat tgcactaaat caatgcagta tattatacat
     6901 tgataaggta gatatgttag aactattttc aagagaaaaa agaattcttg agaatttttt
     6961 agaacttctt agtaataaag tgctaatgct aaattctaaa attaaaaata tatcttttaa
     7021 gaatataagg catagagtta taaattacat attagaaact atgaaactac agaagaatag
     7081 tacaattaaa ttaaaagaaa gtaaagaaag tattgctgca gctttaggaa taccaagacc
     7141 ttcattgtca agggagctaa taaatcttag ggatatggga tatatagatt ttgatagaag
     7201 taatataaaa atattagata tagaagcttt agaagaagaa atgtttaatt aaacattata
     7261 taaaagataa gtattaataa atatggaata caaacaatgt aaataaaaac atttaaaaaa
     7321 atatattatt acaggagttg gtaacatagg ttacggactc ctgtatttat tttatgtaca
     7381 ataagaccat agttcaaatg aattcaatta ttaaatcaac aaagtaaaaa atattattaa
     7441 gaaataaagg ggagttaaat atggagaata agatgttttg ttttcaatgt caagaagcag
     7501 ctggttgcag cggatgtact gtaagaggag tttgtggtaa gacccctgat cttgcaaaac
     7561 ttcaagactt attaatatac agttcaagag gattatcaga agtagctaca agagctaggg
     7621 aagaaggagt aactgtttct aatataataa atagagctgt gactatgaat cttttcacta
     7681 caattacaaa tgcaaatttt gatgacgcag tattctataa aatggttaaa gaaactttaa
     7741 atcttaagga agaattactt tcaaaattaa gcaataaaga agatttaagt gacgctgcat
     7801 tatggacagc taaaacagaa gctgaaatgg atagtaaagc tggtttagta ggagtactgt
     7861 ctactgataa tgaagatatt agaagtttaa gagaaatgat aacttatgga ttgaaaggat
     7921 tagctgcata tgttaaacat gctaatgcat taggatatga tgatgaagcc atatgtgcat
     7981 ttatgcaaaa agctttagct gcaacagcag ataataagat aacaatagat gaatatatag
     8041 cattaacatt agaaactggt aaagttggag tagacggtat ggcattactt gataaagcta
     8101 atactgaaag ctatggacat ccagaaatta caaaagtaaa tattggagta agtaataagc
     8161 ctggaattct tgtgtctgga cacgacttaa aagacttaga gcaattatta attcaaacag
     8221 agggtacagg agtagatgta tacactcact cagagatgtt accagctcac tactatccag
     8281 catttaaaaa gtactcacac ttcataggaa actatggaaa tgcatggtgg aagcaaacag
     8341 aagaatttga gagctttaat ggaccaattc ttatgactac aaactgtatt gtaccaccta
     8401 aagatagcta caaagcaaga gtgtttacta caggtgctgc aggatataca ggatgtacac
     8461 atattgcagc tgatgaaaaa ggaaataaag atttttcagc attgatagaa ttagctaaaa
     8521 cttgtgaagc tccaatagaa attgaacatg gtgaaatcat tggaggtttt gcacacaatc
     8581 aagtattagc cttggctgat aaaattgtag aagcagtaaa aactggagct ataaagaaat
     8641 tctttgtgat ggcaggttgt gatggtagac aaaagaaaag agaatactac actgactttg
     8701 caaaggcatt accacaagat acagtaatct taactgcagg atgtgcgaaa tataaatata
     8761 acaagttaga cttaggtgat attggaggaa ttccaagagt acttgatgca ggtcaatgta
     8821 atgattcata ctcactagca ttaattgctt taaaattaaa agaagtattt gagttagaag
     8881 atataaatga attaccaatc gcatttaaca ttgcatggta tgagcaaaag gctgtaatag
     8941 ttttattatc tctactacac ttaggagtaa aaaacattca cttaggacca acgcttccag
     9001 cattcctatc tccaaatgta gctaatgttt tagttgaaaa ctttggaata ggtggaataa
     9061 ctaacgtaga agatgatatg aaaatgttca tggaaatgta attgaaaaaa taaatatata
     9121 attaagccaa tatgtaacta ttaaaagagg tccactaaaa ttaatattct agtggacctc
     9181 ttaatttagt atatatttct tttatttaag acgagattca atccaagcta gggcacctgg
     9241 atgcatagaa ccatcattat ctaaagtaac ttgagaaatg aaaaatattt cattatcttc
     9301 ttttacttca tctaaagcta gctttatatc cttagaattc atttcagtat gtaaaagaaa
     9361 tgtggttggc ataatgtttg cccaagcccc taaagattta atttttctag gcagattact
     9421 atggtggtga tgatggtcgt ggttgcaatt ctcatcatgc tggtgatcat ggtcacattc
     9481 atgattatga gtttcagcta tataataagt tatttgatat acagacattt tattacctcc
     9541 tctaggtaag tttatggtta tttaacatgt attatacata aaatgaaagt gatttgcaat
     9601 taataattaa ttaaaatgat tatcagtaag aaatataaaa tataaatttt gtagacctaa
     9661 gaaataaaat aatttattat aatgtttaca acttaagtaa tgtatgctat attattggta
     9721 aatgattaca aagaaaagga gcggtatgaa atgaaaaaat tatttatagt tttaaagaaa
     9781 tttaataaaa tccatactgc ttataataat agggttattt aaggctttat ttatgtaatt
     9841 tataatattt tttaattaag taattataat accttgagca gagaaatgga taattttcta
     9901 tgccaaggta tttttttatt aaataattca aggttatgga ggcgtgtaag atgagaatta
     9961 agagtggaat ttttagtgtt agattaagag gctaaaaggt ggatttatga gttgccttaa
    10021 atgtggctat ctaaacatat gatttagata gtagaattta ctccgtatat atcatggaga
    10081 tttctttaaa gaagtaaact ttaaagttaa aattctataa tcatgaatcc gtactatagt
    10141 agtttaaata gtatgattaa aggagattat ggaaatggaa agaaaaggaa tagtagtagg
    10201 aataaatata aataatgaaa atggatttga agaatctatg gttgaactta agaacttatg
    10261 tatggcctgt gatattgaag ctataggaga gcttgtacaa aattcaaaac aaattaataa
    10321 ggcacattat attggaagtg gaaagctaga tgaattaaaa tcattagtaa atagtgaaga
    10381 agtagacata gtaattttta ataatgagct atcgtcatca caattaagaa atatagaaaa
    10441 ggctattgaa tgtgaagtta ttgatagaac tgcactaata ctaagtatat ttgctgaaag
    10501 agcaaaaact agagaagcaa aacttcaggt agaggtagca agacttcagt atttattacc
    10561 aagactaatt ggggctaatg aaaatttagg tcgtcaaagt ggaggtgtag gaacaaaaaa
    10621 caaaggtgct ggagagaaaa agttagagct tgatcgcaga aagattgagg ccaaaatagc
    10681 tgccttaaac aaggaacttg aagagttaaa acatcaaaga gaaacacagc gtaacttaag
    10741 aagaaagtct agtgtgcccc aaatagcctt agttggatat actaatgcag ggaaatcatc
    10801 aattatgaat agtatgatag atacatttaa agatagtgaa gaaaaaaagg tttttgaaaa
    10861 agatatgctg tttgcaacct tagaaacgtc tataagaagt ataaagttag atgataataa
    10921 aaaattttta ttgtcagata cagtagggtt tgtaagtaac ttaccacaca atttaataaa
    10981 ggctttcaga tctaccctag aggaagtttg tgaagctgac ttattactcc atgttgtaga
    11041 tatttctaat ccagattata aacatcatct taaagtaaca aatgaaacat taaaagagat
    11101 aggagcagaa tcagttccta tgatttatgt ttataataag attgacttag tagatgatta
    11161 tttaactgaa aaaaatggag tttatatatc agcaaagaaa aatttaggta tagataaact
    11221 tgtagaaact atatctacta aggtatttaa taattatata aattgtaata tgtttatacc
    11281 ttatgataaa ggaaatttgt tatcttattt aaatgataat gcaagagtta tagatagaaa
    11341 atatagaaat gatggtgctg agttatctat tgagtgttcc aatatagatt atgaaaaata
    11401 tagggaatat gtaataggct aaattaaaaa taattaaaaa atattaaaaa gtattgacag
    11461 aagttcaata tgcatataat attaatagca tataaattca agaaattcta tgaagagaaa
    11521 aagtaagtag tatttttgtt ccaaagagag ttggcatttt gctgaaagcc aatgttcaat
    11581 atacaactga aaatcatctc tgagaagcaa cgccgaaata ttttagtagg ttttgccgga
    11641 gtctttcacc gttaaaagaa aagcgtattg ttagatacgt atctaagtgt tgtaattgaa
    11701 tctattaatg tattgttttt agatttgttt acagaattag ggtggtaacg cggtttaacc
    11761 cgtcccttgt ttttcaaggg acgggttttt tattttacat taaaatttga aaatgtaaat
    11821 aagtaaaggc atagaagatc ttttggatgt atatcagtgc taaaagaata gaactaaggc
    11881 actaataaac tgaaaagggg gaacattatg gatattcaag gtgatattat tagctagtag
    11941 aaaattcaca gcataaacga gggggaataa aaaatgaaca acttatcaaa aaaagattta
    12001 gtattaataa gcttaatgct tttctcatta ttctttggag ccggaaattt aatatttcca
    12061 ccatttctag gacaattagc agggggagca acttggattt ctatggcagg attttttata
    12121 actgcagtag gatttcctgt tttaggagta gttgcagtgg ctaaatcagg gggactacat
    12181 aatttggcta aaagagttaa tccgttattt gcaggggtat ttacagtact tatatattta
    12241 tctattggac cttgtttagg tattccaaga gctggaagtt taccttttga aatggctgta
    12301 gcaccatatt tgccagaaag tatatcaaaa atctgggcac tttttatttt tactttaata
    12361 ttcttttcag tagcttattg gctttcatta acccctgcta aattagtgga tcgtatgggt
    12421 aagtttttga caccaatcct attagtacta atttcactaa tttttatagc atcaattttc
    12481 agaccattag gtagttatgg ggtagccaca gaagagtatg taaattcacc ttttgttaaa
    12541 ggctttttag atggatactt aactatggat accatagccg ctttaaattt tggaatagtt
    12601 atagctttag ctataaaatc taaaggaatt aaggatgaaa aagcaattat ctctacatct
    12661 gtaaaggctg gtgtaggcgc aggcggatta ttaatagtag tttattctat actggcacat
    12721 ctaggagcaa ctagtggagg aagatttgga actactgaaa atggagcaca aactttaaca
    12781 aatatcatga cttatatatt tggaaaacca ggtgctgtac tgttagcagt gatatttaca
    12841 ttagcttgtc ttacaacctg tgttggactt ataacttcct gtagtcaata cttttccgca
    12901 ttaaatagta aattatcata taaaaattgg gttagaatat tatcactttc cagtatgatt
    12961 cttgccaata tgggattaac aaaaattctt gctatatcag taccagtatt aaatgcaatt
    13021 tatccaatag caataatgct tatagtcctt gcaatgctag ataagttttt taatggaagt
    13081 acagtggtat atggattaac aatattgttt acgggaattg taagtgtagc tgatgcatta
    13141 gggcaagttg gaatacaatg gaactttatt gtgaatttat ttagcaagtt accgctctat
    13201 tctaaaggat taggatgggt ggtgccagcg ctaattggta tagtattggg aactgtatac
    13261 aagttagttg aagaaaaaat aagctatagt aaagtaagtg aattataaaa atactctata
    13321 actataattt ccaacataac ctagaagaaa ggcatgggat aagtatatta aaattataag
    13381 gggaataatt ttaataaaac tgttgacatt cacgttacgt aaagctgtat attaaatatt
    13441 aggaggagtt agaatatgga atatacagtg caaaatttag gtaagttagc agggataagt
    13501 acaagaaccc ttagatacta tgatgaaata ggaattctta agccggcaag aattaattca
    13561 tcaggatata gaatttatgg gcaagcagaa cttgatagac tgcaacaaat actgttttat
    13621 agagaattag gggttagttt aatagatata aaaaatataa taaatgaacc ttcctttgat
    13681 gggattaatg cacttataga acatcgcctt aaactccttg aaaaaagaaa acaaatagat
    13741 ttgttaatag ctaatgttga aaagaccata gctaacaaaa aaggaggaat taagatgagt
    13801 aataaagaaa agtttgaagg gttcaaacaa aaactaatag ataaaaatga gaagaaatac
    13861 ggtaaagaaa taagagaaaa atatggtgat gaggaagtaa ataaatctaa tgcaaaagta
    13921 aaagctatgt cagaaaaaga atatgaggaa gtaacaaacc ttgcagaaga aattatgaat
    13981 actttatcag cagcttttaa aacaggtaat ccagctggag aactagctca gaaaacagca
    14041 gaattacatc gcaaatggat agaatattac tggagcagtt acagtaaaga agcccatgca
    14101 ggacttgccc aaatgtatgt ggatgatgaa agatttacag catattatga tgctaaacaa
    14161 ccaggaatgg cagctttttt aagggatgct atattcatat atacaggaac tgataaatat
    14221 taatataaac attaaaattt aaggatatga aagggtgtct ccaaagtata agtttactaa
    14281 aataaactta aggtaaggct ttggagacac ccttatttat caattaaatg agttataaaa
    14341 acttcccttt ttacaaagta gagaatctat atctgcaaaa ggaattttga aggtaacaaa
    14401 accagcagca taaggtgcaa tctcataagg tgcaaaaaat at
//
