LOCUS       c00087_NZ_JAQC..       15433 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_JAQCOQ010000087.1 Phocaeicola coprocola strain AF02-37
            AF02-37.Scaf87, whole genome shotgun sequence.
ACCESSION   c00087_NZ_JAQC..
VERSION     c00087_NZ_JAQC..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 01:33:33
            Original ID  :: NZ_JAQCOQ010000087.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15433
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15433
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[8936:11974]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      8937..11974
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..15433
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15433
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             complement(97..540)
                     /locus_tag="ctg87_1"
                     /transl_table=11
                     /translation="MKKLVFFLVCLFTMQVVVADNDKPVTFEQLPQAAQSFVKKHFADR
                     NVAFSKMDKDIFDVTYDVMFVNGDKLEFDKQGNWKEMKCKHGLVPETAVPAQIVKYVKT
                     NYPEAKILQIEKDRYEYEVRLSNFWDLKFDLKFNLIDMDRDDD"
     CDS             complement(578..739)
                     /locus_tag="ctg87_2"
                     /transl_table=11
                     /translation="MFRKFVKISEISKCLDISGKCVSIKSGVEEKITVNFGNSQFFSES
                     VGSFAIEN"
     CDS             766..2271
                     /locus_tag="ctg87_3"
                     /transl_table=11
                     /translation="MRTNIYALLLAALFTSCTATENQKKQDKTEPVSTTVRLLEGDMPD
                     PSVVRVGNTYYMVHSSFIYTPGLVVYSSKNLADWTPCSAALPEYTGDIWAPDICVYDNR
                     FYIYFPTRNEKGEKTNMVTWADSPEGPWSKPVDLKVGGIDPEHVVDEKGNRYLLLSAGD
                     LHPLSADGLSITGKPEIIYKGWEIPEEWDIESFSLEGLNVKKINDWYYLLAAEGGTAGP
                     PTGHMVVQARSKSVHGPWENAPENPLLRTQSPQETWWSQGHGSVVDTPEGKLMLFFHGY
                     EKGYLTLGRQTLTREVVIGDDGWLHLTDKPAPLPEPQRPSLRTAKDFIWQAAGENFSAR
                     FHVTPELITLKAKGKSPKDASPLLARAGDHRYEIEACLELNNAEASAGLVIYYNKDMHF
                     GLGFRPGELLRYRRGAIHTSQPKTEITVNDGKCRLWVRLRNYDNIISGWYSTDGKTWHK
                     YPWGFDMQGYHHNTLGEFLSLRPGIYAGGEGEVHVTDFTYRTL"
     CDS             2463..3536
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GDP_Man_Dehyd"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg87_4"
                     /sec_met_domain="GDP_Man_Dehyd (E-value: 5e-155, bitscore:
                     505.2, seeds: 258, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKVALITGITGQDGSYLAEFLIEKGYEVHGILRRSSSFNTGRIE
                     HLYLDEWVRDMKQSRLVNLHWGDMTDSSSLIRIIGDIHPTEIYNLAAQSHVKVSFDVPE
                     YTAEADAIGTLRLLEAVRICGLEKTCRIYQASTSELFGKVQEVPQKETTPFYPRSPYGV
                     AKQYGFWITKNYRESYNMFAVNGILFNHESERRGETFVTRKITLAAARIKQGFQDKLYL
                     GNLDAQRDWGYAKDYVECMWLILQHNTPEDFVIATGEMHTVREFCTLAFHYLGIELEWQ
                     GSGVDEKGIDRETGRVLVEVDPKYFRPCEVEQLLGDPTKAKTLLGWNPTKTPFAELVRI
                     MVEHDMKFVKKLHYKSI"
     CDS             3656..4756
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Epimerase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg87_5"
                     /sec_met_domain="Epimerase (E-value: 5.9e-86, bitscore:
                     277.2, seeds: 96, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDKSSKIYVAGHRGLVGSAIWNNLMQRGFTNLVGRTHKELDLLD
                     PIAVREFFDKEQPDAVVLAAAHVGGIMANLQYRADFIYRNLQIQQNVIGESFRHGVKKL
                     LFLGSTCIYPREAMQPMKEEALLTSPLEYTNEPYAIAKIAGLKMCESFNLQYGTNYIAV
                     MPTNLYGPNDNFHLENSHVLPAMIRKIHLAKCLNTNNWEAVRKDINLRPVEGVDGNCTD
                     QEILDKLAKFGITPQAVTLWGTGKPLREFLWSEEMADASVHVLLNVDFKDTYAEGAKEV
                     RNCHINVGTGKELSIREVAEKIMKEIDFKGKLQWDSSKPDGTMRKLTDVSKLHALGWHH
                     KVEIDEGIHRLYEWYLKGICINHQTT"
     CDS             4763..7621
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GHMP_kinases_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GHMP_kinases_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg87_6"
                     /sec_met_domain="GHMP_kinases_C (E-value: 2.4e-10,
                     bitscore: 30.2, seeds: 112, tool: rule-based-clusters)"
                     /sec_met_domain="GHMP_kinases_N (E-value: 7.6e-10,
                     bitscore: 28.5, seeds: 447, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLLSLPPNLVECFHDIEHANHQEWFCTSDPVGSKLGSGGGTAW
                     LLQACKNSESDTTPLTEWLAHEKRILLHAGGQSRRLPSYAPSGKILTPIPVFRWGRGQK
                     LTQNLLSLQLPLYEQIMQKAPEKLHTLIASGDVYIRAEQALQEIPDADVVCYGLWVDPE
                     LAKNHGVFVSSRNTPEKLDFMLQKPSVDELGALMQNYLFLMDIGIWLLSDRAVELMVKR
                     SLKEDGSIGFYDMYSDFGPALGSHPRINDPEINKLTVAILPLPGGEFHHYGTSREMISS
                     TLAIQNCVIDQRAIMHKKVKPHPAIFVQNALTDYTLTSENSEVWIENSCISKNWTLHKR
                     NIITGVPVNQWHINIPEGICIDVIPMGESNYVARPYGFNDAFKGSLKDDSTLYQGIPVQ
                     KWLSDRDLTADEIACNHDLQAARIFPICTSVDELGIVMRWMTDEPKLNEGKDIWIHAQK
                     VSADEISAYANLRRLTEQREAFRKNSWTALAKNYERSVFYQLNLQEAAEEYAHHQLELP
                     APLPSSAPLMTRISDAMFRARTLQLRDSDGHLVEEIAREEEKAFSLMREGLTSTVDHKQ
                     HPRLSVYPDQIVWGRSPVRIDLAGGWTDTPPYSLMEGGNVVNIAIELNGQPPLQVYVKP
                     CNEYKIILRSIDLGAMEVITTFDELHTFNKVGSPFSIPKAALVLAGFHPDFSAERCTSL
                     EEKLRSFGAGIEVTLLSAIPAGSGLGTSSILASTVLGAINDFCGLNWDKHEIGSRTLIL
                     EQLLTTGGGWQDQYGGVLQGVKLLQTQPGWNQEPMVRWLPEHLFTHDEYQKCHLLYYTG
                     ITRTAKGILAEIVRGMFLNSTEHLNLLGQMKQHAIDLYDAIQRNSFEEMGRLIRKTWQQ
                     NQALDSGTNPNSVAAITQQIDDLCLGYKLPGAGGGGYLYMVAKDPEAALRIRKILTQNP
                     PNDRARFVEMSLSNKGLEVSRS"
     CDS             7642..8856
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 74.1; E-value: 3.3e-23)"
                     /gene_kind="transport"
                     /locus_tag="ctg87_7"
                     /sec_met_domain="MFS_1 (E-value: 5.3e-24, bitscore: 74.1,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPKIRLVQTADGVNYLVPFVLITTLFFLWGFAHSILDVLNKHFQ
                     DALSISKTHSALIQAVVYGGYFLMAMPAGEIIRRHGYRAGVVTGLLLYGIGALMFIPGE
                     QIMSFEFFLLSLFIIGCGLTCLETAANPYVTVLGDKDSAERRINLAQSFNGLGWICGPL
                     VGGLFLFAADGGSGSIAIPYAIIGILVLLVAIVFSRIHLPEITLAEEPVETANNKQSSL
                     WQHRNFTFGLIALFFYVAAQTGINSFFINYVTEHISISAREAALWLSFVGMGLFMAGRM
                     GGSWLMGFIRAERLLTYMAAGAILAMILVMLGMGVISVGAFFLCFLCESIMFPTIFALA
                     IRGVGEHTKRASSYLIMSIVGGAIAPIIMGYIADTISTATGFIVPLLCFIVILAYAIHL
                     QKNNR"
     CDS             complement(8937..9725)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 76.1;
                     E-value: 1.1e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg87_8"
                     /sec_met_domain="Radical_SAM (E-value: 1.4e-29, bitscore:
                     93.1, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LSFSSLSWAANVFSLINIEQMIRVHSYESLGTYDGPGIRLVVFLQ
                     GCNFRCLYCANPDTIDAKGESKETAPEDILKMAVSQKPFFGKKGGITFSGGEPTFQAKA
                     LIPLFRMLKEEGIHICVDTNGGIWNEDVKELFSLADLVLLDVKEFNNERHKTLTSRSNE
                     QTLRTAAWLEENGKPFWLRYVLVQGYSFFREDIEALGENFKDYRMIQRVEILPYHTLGV
                     HKYEAMKLEYKLKGVKQNTPEQLEEARTLFEKYFDTVYVN"
     CDS             complement(9758..11974)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg87_9"
                     /sec_met_domain="Gly_radical (E-value: 6.7e-47, bitscore:
                     148.0, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate1 (E-value: 0.0, bitscore:
                     1194.2, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFKEGRWNHEINVTDFVKTNITPYEGDASFLAGPTERTKAVWNK
                     CLEALAEERANNGVRSLDPSTVSTITSFAAGYIDKDNEVIVGLQTDEVLRRAIKPFGGI
                     KVVEKACRENGVEVDPKVKDIFTHYRKTHNDGVFDAYTEEIRSFRSLGFLTGLPDNYAR
                     GRIIGDYRRLALYGIDRLIEAKQDDLRHLTGPMTDERIRLREEVAEQIKALKEIKVMGQ
                     QYGLDLSRPATTAQEAVQWVYMAYLAAVKEQDGAAMSLGNVSSFLDIYIEYDMAHGNLD
                     ELHAQELIDQFVIKLRMVRHLRMQAYTDIFAGDPTWVTESIGGRFNDGRTKVTKTSFRF
                     LQTLYNLGPSPEPNLTVLWSPQLPEGFKDFCARVSIDTSSIQYENDDLMREVRNSDDYG
                     IACCVSYQDIGRHIQFFGARCNLAKALLLAINGGRCENTGTLMVKDIPVLTGDVLNYEE
                     VLANYKKVLKEMARVYNEAMNIIHYMHDKYYYEKAQMAFVDTNPVINLAYGVAGMSIAV
                     DSLSAIKYAKVTAKRNEIGLTESFDIDGEFPCFGNDDDRVDHLAVDLIYYFDEELKKLP
                     VYKNAKPTLSILTITSNVMYGKKTGATPDGRAKGVAFAPGANPMHGRDKNGAVASLSSV
                     AKLRYRDSQDGISNTFSIVPKSLGVDMENRVENLVTMMDGYFIKGAHHLNVNVLNREML
                     EDAMEHPEKYPQLTIRVSGYAVNFIKLSREHQLEVISRSFHERM"
     CDS             13272..14699
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lyase_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FumaraseC_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg87_10"
                     /sec_met_domain="Lyase_1 (E-value: 1.4e-92, bitscore:
                     299.7, seeds: 17, tool: rule-based-clusters)"
                     /sec_met_domain="FumaraseC_C (E-value: 1.9e-25, bitscore:
                     78.6, seeds: 737, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENIKNTRTEHDLLGTRELPADALYGIQTLRGIENFSISKFKLQD
                     YPLFIHGLAYTKLAAAKANNALGLVSDEQLKSIEAACKDILDGKYHDQFQVDMIQGGAG
                     TSTNMNANEVIANIALLHLGKKAGEYEFCSPHDTINRSQSTNDAYPTAIHMGLYASHLK
                     FLPHLEALIEALQKKGDEFAHIIKMGRTQLEDAVPMTLGQTFYGFASILRNEIKHLNEA
                     AADFLVVNMGSTAIGTGICSEPGYAEKTIEALKEITGWEVSLADDWVGATSDTSCMVGY
                     MSALKRVAVKINKICNDLRLLASGPRCGFGEINLPARQPGSSIMPGKVNPVIPEVMSQI
                     AFKVMGNELCVTMAGEASQMELNAMEPIMAQCCFESIDLLINGFDTLRTLCIDGITANE
                     EACRNEVKRSIGVVTALNPYIGYDHSTYIAKKAMETGRSVYDLVLEEGILTQEDLDTIL
                     DPKNMIKPVKLDIKARK"
ORIGIN
        1 gtccccatat ctgttttgat aacctgaaat gaatccacta tgaataatgt aggctaatac
       61 tatagaggca tgccacttta aaattatctt ccttttttaa tcgtcatcac gatccatatc
      121 aatcagatta aatttcaagt caaacttcaa atcccaaaaa ttcgataatc ttacttcata
      181 ttcatagcgg tctttttcta tttgcaagat ttttgcttcc gggtaatttg tttttacata
      241 ttttacaatc tgtgccggaa ctgcagtttc aggcaccaaa ccatgtttac acttcatctc
      301 tttccagtta ccctgcttgt caaattccaa tttatcaccg ttaacaaaca tgacatcata
      361 agtaacatca aatatatctt tatccatttt tgagaaagcc acattacggt ctgcaaaatg
      421 tttttttaca aaactctgag ccgcttgagg aagttgttca aaagtgacag gcttatcatt
      481 gtcagccact acaacctgca ttgtaaacaa acacaccaag aaaaatacta actttttcat
      541 aatcataagt ttttaaagag ttattatttg ttttcgttta attttctatt gcaaaactac
      601 ctaccgattc tgaaaagaat tgggaatttc caaaatttac tgttattttt tcttcaacgc
      661 ctgattttat cgatacacat ttacctgaga tatctaaaca tttggatatt tcacttattt
      721 tgacgaactt gcgaaacata acacttaaca caaattttat taactatgag aaccaacatt
      781 tatgctcttc tgcttgcagc cttatttaca agttgtacag ctacggagaa tcagaaaaaa
      841 caagacaaaa ccgaacctgt ttcaacaaca gttcgcctgt tggaaggcga tatgccagat
      901 ccatcagtag tacgcgtagg taacacttat tacatggtac attcgtcatt catctacact
      961 ccgggactag tggtatacag ttcaaaaaat cttgcagact ggactccctg ctcggcagca
     1021 ttacccgaat atacaggtga catttgggct cctgatattt gtgtgtacga caaccgtttt
     1081 tatatctatt tcccgacccg caatgaaaaa ggagaaaaaa cgaatatggt tacatgggca
     1141 gacagccctg aaggtccatg gagtaaacct gtagatctga aagtaggagg aatagatcct
     1201 gagcatgtag tggatgaaaa aggtaaccga tatctattac tcagcgcagg cgatttacac
     1261 ccattaagcg ccgacggact atccattaca ggtaagcctg aaatcatcta taaaggttgg
     1321 gagatacctg aagaatggga tatagaaagc ttctcattag aaggcctgaa tgtgaaaaaa
     1381 atcaatgatt ggtattatct actagcggct gaaggtggaa ctgccggacc tcctacagga
     1441 cacatggtag tacaggcacg ttcaaaaagc gtacacggtc cttgggaaaa tgcaccagag
     1501 aatccattat tacgaactca gtcaccacaa gaaacctggt ggagtcaagg acacggatca
     1561 gtagttgata ctccagaagg taaattgatg cttttttttc atggatatga gaaaggatat
     1621 cttacgttag gaagacaaac tttaacacgt gaagttgtta taggtgatga cggatggcta
     1681 catctcacag acaaacccgc tccattgccg gagcctcaac gtccgtcatt gcgtacagcg
     1741 aaagatttta tctggcaagc agccggagaa aacttctccg cacgcttcca tgtcactcca
     1801 gaactcatca cactgaaagc aaaaggtaaa agtcccaaag atgcctctcc ccttcttgca
     1861 cgtgcaggtg atcaccggta tgaaatcgaa gcatgccttg aactaaataa tgcagaagct
     1921 tcagccggat tagtcatcta ctacaataaa gacatgcatt ttgggttagg attccgtccc
     1981 ggtgaacttc ttcgttatcg ccgtggagcc atacatacca gccagcccaa aacggaaata
     2041 accgtaaatg atggaaaatg ccgcttatgg gtacgcttac gcaattatga caacattatt
     2101 tccggatggt acagcaccga cggtaagaca tggcacaaat atccatgggg atttgacatg
     2161 caaggctacc atcacaatac attgggagaa ttcctctctc tccgtcctgg catatatgca
     2221 ggaggtgaag gtgaagtgca tgtaacagat tttacctatc gtactttata acttaataaa
     2281 aataaaggga atacactggg tacgcaaaca aataaatcgt agagccattt gccgaaaaat
     2341 ccaatttcaa gaagacgtga ataatatgga aataatataa accgcacttg gcaatacagc
     2401 ttttttgaca tatctttgtg ttgagaaata aaaaaaccaa cctattcagt aaagttttat
     2461 ttatgagaaa agttgcttta ataaccggta ttaccggaca agacggttca taccttgccg
     2521 aattccttat agaaaaagga tatgaagtgc acggtatttt acgccgttct tcatcgttca
     2581 atacgggacg tatcgaacac ctttatttag atgaatgggt gcgcgacatg aaacagtcac
     2641 gtttggtgaa cctacattgg ggagatatga cagactccag ttcgcttatc cgaattattg
     2701 gtgatattca tcctacagaa atctacaatc tagcagcaca gagccatgta aaagtatcat
     2761 tcgacgtgcc agagtacaca gccgaagccg atgccatagg cacattgcgt ttattggaag
     2821 ctgtacgtat ttgcggtttg gaaaaaacct gtcgcatcta tcaggcttct acctcagaac
     2881 tctttggcaa agtgcaggaa gttccacaaa aggaaaccac accgttctat ccccgttcgc
     2941 cttatggtgt agcaaagcaa tatggtttct ggataacaaa gaactatcgt gaaagttata
     3001 atatgtttgc tgtaaacggt atcttgttta atcatgaatc agaacgacgt ggagaaactt
     3061 ttgttacacg aaagatcaca ttggctgcag cacgcattaa acaaggattt caggataagt
     3121 tatatctagg taatctagat gcacaacgcg actggggtta tgctaaggat tatgtagaat
     3181 gcatgtggct tattttacaa cacaataccc ctgaagattt tgtcattgct acaggagaaa
     3241 tgcataccgt acgtgaattc tgtacactag ctttccacta tttaggtatt gaacttgaat
     3301 ggcaaggtag tggagtagac gaaaaaggta ttgaccgtga aaccggacga gtattagttg
     3361 aagtagatcc caaatacttc cgcccatgtg aagtagaaca acttttagga gacccaacga
     3421 aagccaagac tcttttggga tggaatccta ccaaaacgcc ttttgcagaa ttagtccgta
     3481 tcatggtaga gcatgatatg aaattcgtaa aaaaattgca ttataaatca atatagcagt
     3541 gtcatttcct gcaaaagaca ctactttaat tttaccgata aattcattaa aaatgaattt
     3601 ggggcgcgga cttagtgatt aagttcgcgt tcctacttta aaaaagagaa tcacaatgct
     3661 agacaaatct tcaaaaatat acgtggcagg acaccgaggt ctggttggat ctgccatctg
     3721 gaataatttg atgcaacgcg gttttaccaa tctggtagga cgtacccata aagagcttga
     3781 tttgttggat ccgatagcag tacgagagtt ctttgacaaa gaacagcctg atgccgtagt
     3841 attagctgct gcacatgtag gaggaattat ggccaacctg caataccgcg ctgatttcat
     3901 ttaccgcaat ttacagattc agcagaatgt aataggtgaa agtttccgtc acggggtaaa
     3961 gaaactattg tttttaggca gtacatgcat ctaccctcgt gaagcaatgc agccaatgaa
     4021 agaagaagct cttcttactt ctccgttaga atatactaat gagccatacg ctatcgccaa
     4081 aatagcagga ctgaaaatgt gtgaaagttt caatttgcag tatggcacga actacattgc
     4141 tgttatgcca accaacctgt atggtcctaa tgataatttt cacctggaaa acagtcatgt
     4201 attgccagca atgatccgta aaatccatct tgctaaatgc ttgaatacga ataactggga
     4261 agctgtacga aaagatatca acctacgtcc ggtagaaggt gtagacggca actgcacaga
     4321 ccaggaaatt cttgataaac tggctaaatt cggcattacc cctcaagccg ttactttatg
     4381 gggaacaggc aagccattac gcgaattttt atggagtgag gaaatggcag acgccagcgt
     4441 acatgtatta ttaaatgtcg atttcaaaga tacctatgca gaaggggcaa aagaagtacg
     4501 caactgccac atcaacgtag gtacaggaaa agagctgtca atccgtgaag ttgcagaaaa
     4561 aatcatgaaa gaaatagact ttaagggcaa gctgcaatgg gattcatcaa aacctgatgg
     4621 cacaatgcgt aagcttaccg acgtttctaa acttcatgcc ttaggctggc atcacaaagt
     4681 agaaatcgac gaaggaatac atcgccttta cgaatggtat ctgaaaggta tttgcatcaa
     4741 tcatcaaacg acataatcca atatgaagaa acttttatcg cttccaccta atctggtgga
     4801 atgttttcac gatatagagc atgccaacca tcaagaatgg ttctgtacat ccgatccggt
     4861 aggttcaaag ttaggttcag gtggtggaac tgcatggtta ttacaagcat gcaaaaacag
     4921 cgaaagtgac actactccac tcacagaatg gcttgctcac gaaaaacgta tcctgctaca
     4981 cgccggcggc caaagtcgga gattaccctc atatgctcct tccggtaaaa tacttacccc
     5041 aatcccagtt ttccgctggg gacgtggtca aaagcttaca caaaacttat tgtcacttca
     5101 gcttcccctg tatgagcaaa tcatgcagaa agccccggag aaattgcata cacttattgc
     5161 cagcggagat gtatatatcc gtgcagaaca agccttacaa gaaatccccg atgcagacgt
     5221 tgtatgttac ggactgtggg tagatcctga actggcaaag aatcacggtg tttttgtttc
     5281 atcacgcaat actcccgaaa agctggactt tatgcttcaa aagccgagtg tagatgaatt
     5341 aggagcattg atgcaaaact atctgtttct gatggatatt ggcatttggc tgctgagtga
     5401 ccgggctgta gagttaatgg taaaacgttc actcaaagag gatggatcaa tcggcttcta
     5461 cgatatgtat tctgacttcg gaccagctct aggtagccat cctcgtatca acgatcccga
     5521 aataaacaaa cttacagtag caatcctgcc attgccgggt ggtgaatttc atcactatgg
     5581 aacaagccgg gagatgattt cgtctacact ggcaatacaa aattgcgtaa tcgaccagag
     5641 agcaattatg cacaagaaag taaagcctca tccggctatc ttcgtgcaaa atgcactgac
     5701 cgactataca ctgacatccg aaaactcaga ggtatggata gaaaacagtt gcataagtaa
     5761 aaactggaca ctccataagc gcaatatcat aacaggagta cctgtcaatc aatggcacat
     5821 caatattcct gagggaatct gtattgacgt cataccgatg ggagaaagta attatgtggc
     5881 ccgtccctat ggatttaatg acgctttcaa aggcagtctg aaagatgatt caaccttata
     5941 tcaaggaata ccggttcaga aatggttatc agaccgtgac ctgacagctg atgaaatagc
     6001 atgtaaccat gatcttcagg ctgcacgcat attcccgata tgtacatctg tcgacgaact
     6061 tggaattgtc atgcgttgga tgacagacga gccgaagttg aacgagggaa aagatatctg
     6121 gatacacgca caaaaagttt cagccgatga gatttcagct tatgccaatc tgcgccgtct
     6181 gacagagcag cgtgaagctt tccgtaaaaa cagctggact gccctggcta aaaattatga
     6241 acgcagtgta ttctatcagc tcaatttgca agaagcagcc gaagaatatg cacatcatca
     6301 attagaatta cccgctcccc ttccctcctc tgcaccgtta atgacccgta tcagcgatgc
     6361 aatgttccgt gcacgaacat tacaactgcg tgattcagac ggccatttgg tagaagaaat
     6421 agcacgggaa gaagaaaaag ctttcagcct gatgcgtgaa gggcttactt caacagtcga
     6481 ccataaacag caccctcgtc tttcggtgta tccggaccag attgtatggg gacgcagtcc
     6541 ggtacgtata gacttagctg gaggttggac agatacccct ccatacagtt tgatggaagg
     6601 aggaaacgtg gtaaacattg caatagagct aaacggtcaa cccccgttac aagtctatgt
     6661 caaaccctgt aatgagtata aaatcatcct tcgttccatc gacttgggtg caatggaagt
     6721 tatcaccact ttcgatgaac tacatacatt caataaagta ggctctccct tctctattcc
     6781 taaggcagcg ttagtactgg caggtttcca tcccgacttc tcggcagaaa gatgtacttc
     6841 actggaagaa aaattacgtt cattcggagc tggtatagaa gtaacactat tgtctgctat
     6901 tccagccggc tcaggattag gaacaagctc tatcctagcc tctactgtat taggagcaat
     6961 aaacgatttt tgtggcttaa actgggacaa acacgaaatc ggaagccgta cactgatatt
     7021 agaacagttg cttacaaccg gaggcggatg gcaagatcaa tacggaggcg tgcttcaagg
     7081 tgtgaaactc ttgcagacac aacccggatg gaaccaggag ccaatggtgc gctggttgcc
     7141 agaacacttg tttacacacg atgaatatca aaaatgtcat ctattatact atacaggtat
     7201 cacacgtacc gcaaaaggta ttttggcaga aatcgtacgt ggcatgttcc tcaattctac
     7261 agagcacttg aatttactgg gacaaatgaa acaacatgcc atcgatctat acgatgcaat
     7321 ccagcgaaac agtttcgagg aaatgggaag attaatacgc aaaacatggc aacagaatca
     7381 ggcactcgat tcaggaacca atcctaacag tgtagcggcc attacccaac agatagatga
     7441 tctttgtttg ggttataaac ttccaggagc cggaggcggt ggctatctat acatggttgc
     7501 caaagaccct gaagccgcct tgcgtattcg taaaatactt acccagaacc cgccaaacga
     7561 ccgtgcccgt tttgtagaaa tgagcctttc caataaaggt ctggaggtaa gccgtagtta
     7621 ataactatca aacaaaaaca tatgaaacca aaaataagac tggtgcaaac ggccgacggg
     7681 gtaaattacc tcgtcccgtt tgtacttatc actacactat tctttttatg gggatttgca
     7741 catagcattc tggatgtgct aaacaaacat tttcaagatg cattaagtat ttcaaaaact
     7801 cattcagcac ttatacaagc ggtagtttat gggggttact ttctgatggc catgccagca
     7861 ggagaaataa tccgtcgtca tggctatcgg gcaggagttg tcactgggtt attgctttat
     7921 ggcatcggtg cactcatgtt tatccccgga gaacagatca tgtctttcga atttttctta
     7981 ctctcactgt ttattatcgg atgtggatta acctgcctag aaacagcagc caacccatat
     8041 gtaacggtgt taggcgataa agactccgcc gaaagacgaa taaatctggc acaatcattc
     8101 aatggactgg gctggatctg cggcccactg gtaggaggct tgttcctctt tgccgcagat
     8161 ggaggaagcg gaagtattgc tatcccctat gccattatcg gcatattagt tctgctcgta
     8221 gcaattgttt tctcacgcat tcatctgcct gaaattacac ttgccgaaga gccagtcgaa
     8281 actgcaaaca ataagcaaag ttctttatgg cagcatcgca attttacctt cggactgata
     8341 gctctgtttt tttatgttgc agctcaaaca ggtattaaca gtttcttcat caattatgtg
     8401 acagagcaca tcagtatatc cgcacgtgag gcagccctct ggttgtcatt tgtcggcatg
     8461 ggacttttta tggccggcag aatgggagga agctggctga tgggattcat ccgtgccgaa
     8521 cgtttattaa cgtatatggc ggcaggagct attctagcca tgatcttagt gatgttaggt
     8581 atgggagtca tatcggtagg agcatttttt ctttgcttcc tatgcgaatc tattatgttt
     8641 cccaccattt tcgcacttgc catacgaggt gtaggtgaac atactaaacg cgcatcttcc
     8701 tatcttatta tgagtattgt aggaggagcc atagctccca taattatggg atacatcgca
     8761 gatacaataa gcacagctac aggctttatc gttccgttgc tttgttttat tgtcatcttg
     8821 gcctatgcaa tccatttgca aaagaataac cgctaaataa aaaagcctga tgcaaagtta
     8881 aacaccatgc atcaggctga caaataactc gaaagattat attcagagcg tataaatcaa
     8941 tttacataaa ctgtatcaaa atacttttca aataacgtcc gggcttcttc cagttgctcg
     9001 ggcgtatttt gtttcacacc tttcagttta tactccagct tcattgcttc atatttatgt
     9061 actcctaagg tatgatacgg aagaatttcc acccgttgta tcatgcgata atctttaaaa
     9121 ttctctccta acgcctcaat atcttcccga aagaagctat agccctgcac cagtacataa
     9181 cgcagccaaa atggttttcc attttcttcc agccatgccg ccgtacgaag tgtttgctca
     9241 ttgctacgtg aggtaagagt cttatgacgt tcattattga attctttcac atcaagcaaa
     9301 actaagtctg ccagtgaaaa gagttctttt acatcttcat tccagatacc cccgttagta
     9361 tcaacgcaga tatgaatacc ttcctccttt aacatccgaa acaatggaat cagcgcttta
     9421 gcctgaaaag tcggttcacc tccactaaat gtaattcccc ctttctttcc gaaaaaaggt
     9481 ttctgactga cagccatctt caaaatatct tcaggagcag tttccttact ctctcccttt
     9541 gcatcaatgg tatcagggtt ggcacaatac aaacaacgga aattacagcc ctgcaaaaag
     9601 acaacaaggc gaatccccgg accatcgtac gtaccaagcg attcatatga atgtactcta
     9661 atcatctgtt caatattaat taaagaaaaa acatttgccg cccagctcag cgaggagaac
     9721 gacaaatgtt ttacatatca agtaatgatt accaaaatca catacgttcg tggaagctac
     9781 gagaaataac ctccaactga tgctcgcggc tcaatttaat gaagttgaca gcatatccgg
     9841 aaacacgaat cgtaagttgc ggatattttt ccggatgctc catagcatct tccagcatct
     9901 cacggttcag cacatttacg ttcaggtgat gagcaccctt gataaaatag ccatccatca
     9961 ttgtaacaag attctctaca cgattctcca tatctacacc aagcgatttc ggaacaatag
    10021 agaacgtatt actgataccg tcctgtgagt cacgataacg caatttagca accgagctca
    10081 aagaagcgac agcaccattc ttatcacgtc cgtgcatcgg gttagcacct ggagcaaaag
    10141 caacaccttt tgcacgtcca tcaggagttg caccagtctt cttaccatac atcacatttg
    10201 aagtaatagt aagaatagac aatgttggtt ttgcattctt gtataccgga agcttcttca
    10261 attcctcatc aaaataataa atcaagtcga cagccaaatg gtctacacgg tcatcatcat
    10321 taccgaagca tgggaattcg ccatcgatat caaagctttc agtcaggccg atttcattac
    10381 gtttagcggt aactttagca tatttgatag ccgaaagtga atcgacagca atagacatac
    10441 ccgctacacc atacgccaga ttgataaccg gatttgtatc aacaaatgcc atctgagctt
    10501 tttcataata atatttatca tgcatgtagt gaatgatgtt catcgcttcg ttatacacac
    10561 gagccatttc tttcaagacc ttcttatagt tagccagcac ctcttcgtag ttcagtacat
    10621 ctcccgtcag cacaggaata tccttcacca tcagtgttcc tgtattttca cagcgtccac
    10681 cattaatagc cagcaacaaa gctttagcca gattacaacg tgcaccgaag aactgaatat
    10741 gacgacctat atcctgataa gacacacagc atgcgatacc atagtcatcc gaattacgta
    10801 cctcacgcat caaatcatca ttttcatact ggatagatga tgtatcaatc gacacacgag
    10861 cacagaaatc cttgaatcct tccggcaact gcggactcca cagaacagtt aagttaggtt
    10921 ctggagaagg acccaggtta taaagagtct ggaggaaacg gaatgaagtc tttgtgactt
    10981 tcgtacggcc atcattaaaa cgtccaccaa tagattccgt tacccaagtc gggtcaccgg
    11041 caaagatatc cgtataagcc tgcatacgaa gatgacgcac catacgcaac ttaatgacaa
    11101 actggtcaat caactcctga gcatgcaact catcaagatt tccgtgagcc atatcatact
    11161 caatataaat atcaaggaat gacgaaacat taccaagtga cattgcagca ccatcctgtt
    11221 ctttcacagc agccaggtaa gccatatata cccactgaac agcttcctgt gcagtagtag
    11281 ccggacgact caaatcgagt ccgtactgct gtcccatcac ttttatttcc ttcaaagcct
    11341 taatttgctc tgccacttct tcacgcaatc tgattcgctc atcagtcata ggacctgtaa
    11401 gatgacgtaa atcgtcctgt tttgcctcaa tcagacgatc aataccatac aatgccaaac
    11461 gacggtaatc accgattata cgtccacgag cataattatc aggtaatcca gtcaaaaatc
    11521 ccaaagagcg gaacgaacga atctcttcag tatatgcatc aaatacacca tcgttatgcg
    11581 ttttgcgata atgggtaaaa atatctttta ccttagggtc aacctctact ccgttttcgc
    11641 ggcacgcttt ttctaccacc ttaatacctc caaaaggttt gatggcacgg cgtaacactt
    11701 catcagtttg caatcctaca atcacttcgt tatccttgtc aatatatcca gctgcaaaag
    11761 atgtgatagt agaaactgta gaaggatcga gcgagcgtac tccgttgttt gcacgttctt
    11821 cagccaaagc ttccagacac ttgttccata cagcctttgt acgttcggta ggaccagcca
    11881 aaaatgaggc gtcgccttcg taaggggtaa tgttagtctt tacgaaatcg gtaacgttga
    11941 tttcatggtt ccaacgacct tctttaaaat tcattgccat aattgataat ttaatctagt
    12001 ttttactcta tttgaaaacc gaatgcaaag atagtcaata aagcctaatt atacaatacc
    12061 taaaattagt gatattatca atttgcaaca gttacaaaaa tgaatataaa aatcccaacc
    12121 tttgaaaaat taaaatacat ccgacaaata cagacaagca gtccgactca aagaaaaaaa
    12181 ataaaaatct taatcagttt agaatcagaa aactatcgaa acaacaccat agaaggcata
    12241 aaaaaagtat cgcaaaagtt tgcacaaatc aaaaaatcca tctatcttcg caccgcgttt
    12301 gagagaaaac gtaagcagaa acaataaatt tggaagtttg ggtgagtggc tgaaaccagc
    12361 agtttgctaa actgccgtac gggtaaccgt accgggggtt cgaatccccc agcttccgct
    12421 tttagtttct acagatatgg cgctttcgtc tagtggccca ggacgcggcc ctctcacggc
    12481 tgaaacacgg gttcgattcc cgtatgcgct acatttggaa gtttgggtga gtggctgaaa
    12541 ccagcagttt gctaaactgc cgtacgggta accgtaccgg gggttcgaat cccccagctt
    12601 ccgcaacgac ctaagaaatt aggaggaaag aaatagacaa gtcccgtaaa atcaatgttt
    12661 tacgggactt tttttattta tccgacgaac aatcgaaaga cactaaaatg cctacttctg
    12721 acaaagttcc gttactaaat cgttactaaa aatcagcctg taaaaatagt aacgattaca
    12781 agcctcaaaa cgaaatgtga ttattcccca aaacgaattg tgatttttct tcttaaaaat
    12841 acaaaaagct aagaggttaa ttatccccta gctttatata tactttttaa atagtattta
    12901 aatattactt aaatacaatg ctattctttt gggtatagca ttacatctgt ataagtggaa
    12961 ttacaattca ttctcgcatt aaattccgct ttattggcat tcttaaaagg attgccaata
    13021 ttaggatgat tgctcatccg ccctacgctg taaaattaaa ggctttcagc caaaattcat
    13081 ataggaatat agctttttct gctccaagag atattacatt tacgcacaca atttgtaagc
    13141 aaaacacatt acttataccc tatgccacta tataaaacaa taaaaatact atttaacaca
    13201 ataatatttg cttacataat gttagtttat atctttgcga tataataata acaactaaat
    13261 attaatgcct tatggaaaat atcaaaaata caagaacaga acatgatttg ctgggaacaa
    13321 gagaacttcc ggcagacgca ctatatggaa tacagacact gagaggtatt gaaaatttct
    13381 caataagtaa gttcaaattg caggattatc ctcttttcat tcacggactg gcatatacaa
    13441 aacttgctgc tgcaaaagct aacaacgctt taggtttagt tagcgacgaa caactgaaaa
    13501 gcatcgaagc tgcatgtaaa gatattcttg acggaaaata tcacgaccag ttccaggtgg
    13561 atatgattca aggtggagcc ggaacaagta ccaatatgaa tgccaacgaa gtaattgcta
    13621 acatagcatt attgcatctt ggaaagaaag ctggagaata tgaattctgc tcacctcacg
    13681 acacaataaa ccgctcgcag tcaaccaacg atgcttatcc aacagctatc cacatgggac
    13741 tttacgcaag ccatcttaaa ttcttaccgc atcttgaagc tctgattgaa gctttgcaga
    13801 aaaaaggtga tgaatttgct cacattataa agatgggacg cacacagctg gaagatgccg
    13861 tgccgatgac acttggacaa actttctatg gttttgcaag tatcctgaga aatgaaataa
    13921 aacatcttaa cgaagctgcg gcagatttcc ttgttgtgaa tatgggttca acagccattg
    13981 gtacaggaat atgttccgaa ccgggttatg ctgaaaagac tatcgaagca ttgaaggaaa
    14041 taacaggttg ggaagtaagt cttgccgatg attgggtagg cgcgacttcc gacacttcat
    14101 gtatggtggg ttatatgtct gcactgaaaa gagtagctgt taaaattaat aagatatgta
    14161 atgacttgag attgcttgcc agcggtccgc gttgcggatt cggagagata aatcttcctg
    14221 cacgtcagcc gggttcatca atcatgccgg gaaaagtaaa tccggtaata cctgaagtta
    14281 tgagccagat tgctttcaag gtcatgggaa atgaactttg tgtaactatg gcaggcgaag
    14341 catcacagat ggagctcaac gctatggagc cgataatggc acaatgctgt ttcgaatcta
    14401 ttgatttatt gataaacggt ttcgatactt tgcgtacatt gtgtatcgac ggaatcactg
    14461 caaacgaaga ggcttgccgc aatgaagtta agcgcagtat cggtgttgta acagctctga
    14521 atccgtatat tggttatgat cactcaactt atattgcaaa gaaagcaatg gaaacaggac
    14581 gaagcgttta cgaccttgtt cttgaagaag gaattcttac tcaggaagat ttggatacaa
    14641 tccttgatcc taagaatatg attaagccgg tgaagctgga tataaaggct agaaaatgaa
    14701 ctgaaattaa tcctgacaag cacggaaata ttttggctga aagccttaaa ttatatagta
    14761 cagaccaatg ccctgtattt cagggcgtat ttggtatggg gtattcaaaa cgtagggcac
    14821 tgccctacgt tgtaaaatta aaggctttca gccaaaattc ataattgaaa catgtaaaga
    14881 tccgtcaaaa gagtgttttg aaggcggaga ttttaataaa gacataaatg atgattggtt
    14941 tatattatca gcacttaaat ccggttatga cattcaaaac attgtagtga ttagttctga
    15001 taataactta ttattaaaag caaaagagaa tggtctggta catagaaaga tgccagaaac
    15061 ataccttatt aaagaagaac tatcagaaga agagaaagaa atcaaagcat tgaagcagga
    15121 attggagtaa tataaaaata gacagcctaa acctgctatt agatttagta atagtgaatc
    15181 tcgtattttt ttattttata gtgccatttt gcaatcatcc ccagcataat taaaaatcac
    15241 atcttagtca agttctgcta caattttgct acagaaattt tctatctaca aaaactgtag
    15301 cagaaaattt gaaaagaata aaatcctctc gcaaaagaaa aaatctcaga ctcttgttgt
    15361 aaaaattaaa ttacatcatt agtgtcccgt taaaatcggg acgaattaaa tattaatcaa
    15421 acaaccccgg gaa
//
