LOCUS       NZ_CP009787.1          24667 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP009787.1 Yersinia rohdei strain YRA chromosome, complete
            genome.
ACCESSION   NZ_CP009787
VERSION     NZ_CP009787.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 00:08:25
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2788056
            Orig. end    :: 2812723
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..24667
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[2798056:2802723]"
                     /cutoff="10000"
                     /detection_rule="(Molybdopterin and Form-deh_trans and not
                     (Nitr_red_bet_C or Nitr_red_alph_N) and minimum(3,
                     [Fer4_11, Fer4_4, Molybdop_Fe4S4, Molydop_binding,
                     Ni_hydr_CYTB]))"
                     /neighbourhood="10000"
                     /product="Formate_dehydrogenase"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14667
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Molybdopterin and Form-deh_trans and not
                     (Nitr_red_bet_C or Nitr_red_alph_N) and minimum(3,
                     [Fer4_11, Fer4_4, Molybdop_Fe4S4, Molydop_binding,
                     Ni_hydr_CYTB]))"
                     /neighbourhood="10000"
                     /product="Formate_dehydrogenase"
                     /protocluster_number="1"
     cand_cluster    1..24667
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Molybdopterin and Form-deh_trans and not
                     (Nitr_red_bet_C or Nitr_red_alph_N) and minimum(3,
                     [Fer4_11, Fer4_4, Molybdop_Fe4S4, Molydop_binding,
                     Ni_hydr_CYTB]))"
                     /kind="single"
                     /product="Formate_dehydrogenase"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..24667
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="Formate_dehydrogenase"
                     /region_number="10"
                     /rules="(Molybdopterin and Form-deh_trans and not
                     (Nitr_red_bet_C or Nitr_red_alph_N) and minimum(3,
                     [Fer4_11, Fer4_4, Molybdop_Fe4S4, Molydop_binding,
                     Ni_hydr_CYTB]))"
                     /tool="gutsmash"
     CDS             complement(659..1651)
                     /locus_tag="ctg1_2459"
                     /transl_table=11
                     /translation="MTNKIGWIDNLRAVACIMVVMIHATTYYVTSGAQVGEVNWDIANL
                     LNSASRACVPLFFMISGYLFFGEKSAQSKHFTRIGLCLVFYSAIALIYIATLTHINGWA
                     SLMNILQKPVFYHLWFFYAIIVVYLVSPLINVKPASGRYLAIVILLLAVFANPQTSKYS
                     IDGFQLLPINLYIYGDTFYYLLYALLGRAIGMLNTQGRAISWGAGLLFIASIIFIAIST
                     EKQTRINGSFADTFYMYCGPLVFIAATSLLVWFKNCLNKPVAWLSWLAGHSLAIYGFHA
                     LIIHFIRTHGYDFTDYPILDIFYVFALALALSTLLSMGLQRIDRRRLVS"
     CDS             1993..3222
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 111; E-value: 2e-34)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_2460"
                     /sec_met_domain="MFS_1 (E-value: 1.2e-32, bitscore: 111.0,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQTSFSPATRLGRRALLFPLCLVLFEFTAYIANDMIQPGMLAVVA
                     DFNASVEWVPTSMTAYLAGGMFLQWLLGPLSDRRGRRPVMLVGVAFFVVTCLAILLVNS
                     IEQFIAMRFLQGIGLCFIGAVGYATIQESFDEAVCIKITALMANVALIAPLLGPLGGAA
                     LIHVAPWQTMFVLFAVLGAISFAGLWRAMPETASRKGEKLSVGAMWHDYKLVLANRRFL
                     CGSLALGFASLPLLAWIAQSPVILISGEQLSTVEYGILQVPIFGALIIGNLTLARLSGK
                     TSIPKLIRYGAGPMLIGLMIAAASTLYSSHAYLWMTAGLSLYAFGIGLANAGLVRLTLF
                     SSDISKGTVSAAMGMISMMVFTLGIEFAKVAYLWGNSGVFNLFNLISGLLWLSLVAIFI
                     RKQPETLAAE"
     CDS             3491..3703
                     /locus_tag="ctg1_2461"
                     /transl_table=11
                     /translation="MLRNMLFNNGFTESILKGEQVLNTLKLPDMHQNPCGRVLVSQARV
                     ENYPLITAASKIIDSASGYVTMINN"
     CDS             complement(3738..5675)
                     /locus_tag="ctg1_2462"
                     /transl_table=11
                     /translation="MIIATAGHVDHGKTTLLQAITGVNADRLPEEKQRGMTIDLGYAYW
                     PQPDGNIIGFIDVPGHEKFLANMLAGVGGIDHALLVVAGDDGVMAQTREHLAILRLSGH
                     PTLTVALTKADAVDDERIAQVSQQVMAELAAQGWSAQQVTVFVTAATTGLGISELREHL
                     AQCHQQDENNGRLQRRFRLAIDRAFSVKGAGLVVTGTALAGQVAVGDTLWLTGGNCPVR
                     VRGIHAQNQKTQQAQAGQRIALNISGDISKQQINRGDWLLAQQPPEALDRVLVAVDADT
                     PIQHWQPLHIHHAASHITGRFSLLTNPQSISSQSISSQSINLESTDATSPLILAELLLD
                     TPLWLAENDRLILRDIAAKKTLGGARVIHLAVPKRGKRQPAFLAWLTALAQAKNCREIL
                     GLHLSQGPVSVSRFSWARQLTGQDTAELLASTDSVVAGDIALSLPHAQQAQQTLLHVLC
                     LYHQQHGDQMGLGRARLRRMALPTLDEGLVFRLIDNLLALGELKNTRGWLHLPQHGLAF
                     TEQEQLLWQQVAPHFGDSPWWVRDIATTLQIDEAEMRNLLRKAAQLGHITAIVPDRYYL
                     SQRITQFADLIRELDASQGSASAADFRDRLGIGRKLAIQILEFFDRSGFTRRRGNDHLL
                     RDRGLFSSIA"
     CDS             complement(5672..7060)
                     /locus_tag="ctg1_2463"
                     /transl_table=11
                     /translation="MSAESHLLYRQLPAIDRLLHQPEMATLLAEYGPVLLTETLRKLQL
                     EAREHIRQFDTLADWCTDWPAALRQRLNQRQPALKPVFNLSGTVLHTNLGRAPLAESAI
                     SAVNDAMRGAVTLEYSLDGARRGHRDRAVADLLCELTGAEDACIVNNNAAAVFLMLSVM
                     AAGKQVVVSRGELVEIGGAFRIPDVMRQAGCELVEVGTTNRTHLKDYRQAISEHTGLLM
                     KVHTSNYSIEGFTASVAESQLVALGHEFAIPTATDLGSGSLVDMTRYGLPAEPMPQQLI
                     AAGVDLVTFSGDKLLGGPQAGIILGKKQWIDQLQQHPLKRVLRADKMTLAALDATLRLY
                     QQPDRLTELLPTMRLLTRPAEAIAESAQRVLAALAGNYDTDFTLAVEPCWSQIGSGSLP
                     VDRLPSWAVTFAPKDGSGSTLAALTERWRGLAKPIIGRVTDGRLWLDLRCLENEAALLQ
                     ELAP"
     CDS             7837..9003
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) UDPG_MGDP_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) UDPG_MGDP_dh"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2464"
                     /sec_met_domain="UDPG_MGDP_dh_N (E-value: 1.9e-30,
                     bitscore: 103.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="UDPG_MGDP_dh (E-value: 4.5e-28, bitscore:
                     95.1, seeds: 679, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIAIAGIGYVGLSNGILLSQHHEVVALDIIPEKVEMLNRRESVI
                     IDTELQDYLQNKALNFRATLDKRDAYEGASYIIIATPTDYDPEKNYFNTKSIEAVIQDV
                     MAINPDAVMIIKSTVPVGYTAKTKEKFGCNNLIFSPEFLREGLALYDNLHPSRIVVGER
                     SERAEVFANLLKEGAIKENIPTLFTDSTEAEAIKLFANTYLAMRVSYFNELDTYAASHG
                     LDTRQIIDGVCLDPRIGPHYNNPSFGYGGYCLPKDTKQLLANYNHVPQNLINAIVASNT
                     TRKDFIAADILKRNPKVVGVYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYEPTLQ
                     ETEFFNSRVLTDLDKFKQESDIIISNRMLDVLNDVKDKVYTRDLFGDN"
     CDS             complement(9072..10001)
                     /locus_tag="ctg1_2465"
                     /transl_table=11
                     /translation="MSIRIVPKDQLGKQSEKGSTAGNIPPLLFANLKSLYTRRTERLQQ
                     LALDNPLADYLDFAAKITQAQQKALHDHPLVLDMQAELEQSAISGKPPLDLSVFPRTEH
                     WRKLLSALIAELRPEAPDHIVAVLDNLDKSSVHELELYADALLNREFAKIGSEKAPFIW
                     AALSLYWAQMASQIPGKARAEYGEHRQFCPVCGSIPVSSVVHIGTNNGLRYLHCNLCES
                     EWHVVRIKCSNCEQTGDLNYWSLDSELAAVKAESCGDCGTYLKILYQEKDPQVEAVADD
                     LASLILDAKMEGEGFARSSINPFLFPGE"
     CDS             complement(10001..10645)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Formate_dehydrogenase: Ni_hydr_CYTB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2466"
                     /sec_met_domain="Ni_hydr_CYTB (E-value: 3.5e-23, bitscore:
                     79.9, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKEKRIQRYSAPERINHWIVAFCFMLAAISGLGFFFPSFNWLMN
                     IFGTPQLARILHPFAGVIMFAAFLIMFFRYWKHNLINKEDLEWAKNIHKIAMNEEVGDT
                     GRYNFGQKCVFWAAIISLVLLLASGVVIWRPYFAPSFPIPLIRLALLVHSLAAVGLILV
                     IMVHIYAALWVKGTITAMVEGWVPAAWAKKHHPRWYREVESKRQKRQEEKP"
     CDS             complement(10642..11607)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Formate_dehydrogenase: Fer4_11"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Formate_dehydrogenase: Form-deh_trans"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Formate_dehydrogenase: Fer4_4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1016:4Fe-4S dicluster domain (Score: 24.4; E-value:
                     1.1e-07)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2467"
                     /sec_met_domain="Fer4 (E-value: 1.4e-05, bitscore: 22.5,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_11 (E-value: 2e-25, bitscore: 86.7,
                     seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.0034, bitscore: 15.7,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="Form-deh_trans (E-value: 2.5e-23,
                     bitscore: 79.5, seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLQSQDIIRRSGTNSLTPPPQDRNFQAEVAKLIDVTTCIGCKAC
                     QVACSEWNDIRDEVGYNVGVYDNPADLTAKSWTVMRFSEVEENGKLEWLIRKDGCMHCA
                     DPGCLKACPSEGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLC
                     VDRVGVGQEPACVKTCPTGAIHFGTKESMKEVAAGRVAELKTRGFDNAGLYDPAGVGGT
                     HVMYVLHHADKPQLYHGLPENPTISPTVTFWKGVWKPLAAVAFAATFAASIFHYVGVGP
                     NRVEEEEEEDDKSDSTPSDTASKAPEQTTAEHSDDGETRK"
     CDS             complement(11620..14031)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Formate_dehydrogenase: Molybdopterin"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Formate_dehydrogenase: Molydop_binding"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2468"
                     /sec_met_domain="Molybdopterin (E-value: 9.2e-26, bitscore:
                     88.5, seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="Molydop_binding (E-value: 1.3e-16,
                     bitscore: 58.4, seeds: 74, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNHWVDIKNANLIIVMGGNAAEAHPVGFRWAMEAKIHNNAKLIV
                     IDPRFTRTASVADFYTPIRSGTDIAFLSGVLLYLITNEKINREYVEAYTNASLLVREDF
                     TFEDGLFSGYDADNRKYDKTSWNYQLDENGFAKRDVTLQDPRCVWNLLKEHISRYTPDV
                     VSNICGTPKEDFITVCEYIAETSAADKTASFLYALGWTQHSVGAQNIRTMAMIQLLLGN
                     MGMAGGGVNALRGHSNIQGLTDLGLLSQSLPGYMNLPSEKQPDIETYLKANTPKTLLPG
                     QVNYWSNYPKFFVSMMKSFYGDKAQKENGWGYDWLPKWDKGYDVLQYFEMMSQGKVNGY
                     LCQGFNPVASFPNKNKVVAALSKLKFLVTIDPLNTETANFWQNHGEFNDVDSSKIQTEV
                     FRLPSSCFAEENGSIVNSGRWLQWHWKGADSPGEAMNDGGILAGIFLRLREMYQREGGA
                     VPEQVLNMTWDYLTPENPEPEEVAMESNGRALADITDADGKVLVKKGEQLSTFAHLRDD
                     GTTASGCWIFAGSWTPAGNQMARRDNADPSGLGNTLGWAWAWPLNRRILYNRASADPQG
                     KPWDPKRQLLEWDGAKWTGIDVPDYSAAPPGSDVGPFIMQPEGMGRLFAIDKMAEGPFP
                     EHYEPFETPLGTNPLHPNVISNPAARVFKDDLATMGSHEQFPYVGTTYRLTEHFHYWTK
                     HALLNAIMQPEQFVEIGEKLAAKKGIQHGDTVKVSSNRGYIKAKAVVTKRIRTLNVNGQ
                     EVDTIGIPIHWGFEGVAKKGFLANTLTPFVGDANTQTPEFKAFLVNVEKV"
     CDS             complement(14080..14667)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Formate_dehydrogenase: Molybdopterin"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Formate_dehydrogenase: Molybdop_Fe4S4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2469"
                     /sec_met_domain="Molybdop_Fe4S4 (E-value: 3.9e-20,
                     bitscore: 69.4, seeds: 55, tool: rule-based-clusters)"
                     /sec_met_domain="Molybdopterin (E-value: 2.6e-07, bitscore:
                     27.7, seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQVSRRQFFKICAGGMAGTTVAALGFTPSVALAETRQYKLLRARE
                     TRNTCTYCSVGCGLLMYSLGDGAKNAKESIFHIEGDPDHPVNRGALCPKGAGLVDFIHS
                     ESRLKYPEYRAPGSDKWQRISWDDAFTRIAKLMKEDRDANFIETNDAGVTVNRWLSTGM
                     LCASASSNETGYLTQKFSRALGMLAVDNQARV"
     CDS             15005..15832
                     /locus_tag="ctg1_2470"
                     /transl_table=11
                     /translation="VSQIKPSTTDFPTEICGAKQLNVLQRHHMAEPQRDWLAEEVPVAL
                     VYNGISHVVMMATPKDLEAFALGFSLSEGIIAAPQEIYAIDVTPGCNGIEVNIELSSRR
                     FAGLKERRRAMAGRTGCGVCGIEQLDDIFRPITPLPFTQTFNLNHLDSALAQLKQVQTV
                     GQLTGCTHAAAWITPQGELLGGCEDVGRHVALDKLLGIRAKQPWQQGAVLVSSRASYEM
                     VQKTAMCGAEILFAVSAATTLAVEVATRCNLTLVGFSKPGRATVYTHPQRIIE"
     CDS             15959..16579
                     /locus_tag="ctg1_2471"
                     /transl_table=11
                     /translation="MSYSLPSLPYAYDALEPHFDKQTMEIHHTKHHQTYVNNANTVLEA
                     YPELASYSVEDLIKDLDKVPADKRTFMRNNAGGHANHSFFWKGLKLGTSLGGDLKAAIE
                     RDFGSVEKFQEEFEKAAATRFGSGWAWLVLKDGKLAVVSTANQDSPLMGEAVSGASGFP
                     IIGLDVWEHAYYLKFQNRRPDYIKAFWNVVNWDEAAARFAQAK"
     CDS             complement(16436..16720)
                     /locus_tag="ctg1_2472"
                     /transl_table=11
                     /translation="MPVTFLVQSIGRNWLNFSNKKCQQGHLTGIYTLRLEAVGVSYADV
                     SELLSLSETGCCFVPVNYVPECFDVVWAAVLEFQVVSMFPNIQANNREA"
     CDS             16888..18864
                     /locus_tag="ctg1_2473"
                     /transl_table=11
                     /translation="MAAFSKVFGNFENVKVGKKLGLSFFLMLLLVGIIAGTTAYHFSAI
                     EKHAYKVDLSYKINDEANQAKYNRALYERTYDLKYIKENSEHINEIKSLLTESEKLSWS
                     AENHKIINSISDIAEEYLQQQSNFVNAVAHKDDVRKSWNISETQKNLNELQQNFLNEGA
                     DTNTQILLAEMNQKLMTVRYNARGLLLDRNQEAESSLITSINVANSAANAFMPVLSASQ
                     QQLMAPVISSLATYKDNVLAYLPAYRQELEVGKVMEASANELNKLATQLFTQELQGTHL
                     EINNAQWLLAIAALAALLCGLLISWRMTRQITLPLRTTLAMAERIATGDLTTATKSNRT
                     DELGLLMNAVARMNENLRAMIDDIRVGVSQVSHASGEIAAGNTDLSSRTEQQAAAVEET
                     AASMEQLNATVKQNADNAHHANQLATEASTTAQQGGKLVSDVVRTMNDISGSSKRISEI
                     TSVINSIAFQTNILALNAAVEAARAGEQGRGFAVVASEVRNLAQRSAQAAKEIEGLIGE
                     SVSQVSAGTLLVQNAGKTMDDIVRSVTHVHDIMAEIASASDEQSRGITQVSQAIAEMDS
                     TTQQNAALVEESAAAADSLAEQAILLAQAVAVFRLSESEAETPQHQHAEAVMARHVSAS
                     NSTAARQTSETRQNNQQDNWETF"
     CDS             18943..19617
                     /locus_tag="ctg1_2474"
                     /transl_table=11
                     /translation="MNNPQVYIGKIEPYSGSSPSAIGKRQVQGGIMLTPLGLEGDEQAE
                     TRFHGGPDRALCHYPREHYAYWAQQFPEQADIFSAPAYGENISTLGMTEQNVHIGDIYR
                     WGGAIIQVTQPRSPCYKLNFHFAIKDMSVMMQQTGYCGWLYRVISPGKISESHPLALLA
                     RTSDISVSEAIAIAWHMPFDEEQYRRLLAAAGLSASWSKTMLTRIEEGKIEDFNRRLLG
                     NS"
     CDS             complement(19828..20184)
                     /locus_tag="ctg1_2475"
                     /transl_table=11
                     /translation="MKEHAEIKRLSDMLDAMNHKDPAVIQQGNVDLIAQHMKEKEKLAV
                     EIQRLKEVRVKNLSAEAQKLAQLPFSRPITKKEQADMGTLKKAVRGIVVVHPMTALGRE
                     MGLKEVTGYAKKAF"
     CDS             complement(20276..21757)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2476"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.5e-23, bitscore:
                     81.4, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVVMNEIRYLQVADNLAQAIKNGSLLAGSRLPSVRGYAQSHQVS
                     INTVVAAYRTLEDRGLIEARPQSGFYVCSPSTAVVPTATVGKPVDEVLDLIDTVFAAQR
                     NPRFTNISLACPQTGDFYPSAKLGRIMASLLRREPQLISQYALPPGSQRLRQQIARRAM
                     TLGMLASPADITITHGCMEALQLALRVTTKPGDCVGLESPTYFYLMPLLASLGLKAVEI
                     PTDPQQGLSLDVLELLLEEGRLNALIAMPTVQNPMGYTMPLAAKKRLAQLMNDHQVPLI
                     EDGLYAEIQFGTTLSPAVKAFDRDGWVLFCSSFTKTLAPDFRVGWIDGGRFAEALHKLK
                     AVSSMAEPALLSETLALFLESGGYDHHLRSLRRRYAQQVQLAQQLITRSFPRGTTVTQP
                     AGGFVFWVEFPAGVDTVALFHQLLQEQICLTPGTLYSPSGRYRNAFRLSCCYPFNSRYT
                     GALERLGAVACEMSGLPAGMQWQPLQEVAAEKQTP"
     CDS             22029..22640
                     /locus_tag="ctg1_2477"
                     /transl_table=11
                     /translation="MLDSAFISYVTVMSITPGPNNLLLAASGVNFGLRRTLPMMLGITF
                     GCALQCALMTTLLALILSWVGVIRLPLVTLGGGYLLWLSWKIFNSGTPNARDSQQPMGF
                     IQGALFQAINPKAWLMAMNVAILFTPREGATLSHTLLIMTGFALLNLPCVAVWAVLGDQ
                     LRHALRVNWKLRLFNGVMGGLMAITALWLLADEWLSVVHH"
     CDS             complement(22642..23196)
                     /locus_tag="ctg1_2478"
                     /transl_table=11
                     /translation="MIEQTQAFENRVLEHLNAGKTVRSFLMAAVELLAEALNILVVQVF
                     RKDDYAVKYAVGPLLVGDGPLGELSVRLKLVYALGVITRHEYEDAELLMALREELNHDG
                     TEYRFTDDEILGPFGELHCVAELPPVPTFLRPDEADALLIAMQRQRYQQMVRSTMVLSI
                     TELLSRISQKQVSKLSPLGHA"
     CDS             complement(23293..24456)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Mannitol_dh"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Mannitol_dh_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2479"
                     /sec_met_domain="Mannitol_dh (E-value: 3.5e-25, bitscore:
                     86.7, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Mannitol_dh_C (E-value: 3.2e-66, bitscore:
                     221.1, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKALHFGAGNIGRGFIGKLLADAGAQLTFADVNQPLLDELNKRKS
                     YQVNVVGEQARVEEVKNVSAVNSGSPEVVALIADADIVTTAVGPQILARIAGTVAQGLV
                     TRHQQGNTRPLNIIACENMVRGTSQLKQHVFAALPEDEQAWVEQHVGFVDSAVDRIVPP
                     SEAGSTDILAVTVETFSEWIVDGTQFKGQPPEIAGMELTDNLMAFVERKLFTLNTGHAI
                     TAYLGQLAGHQTIRDAILDPAVRQTVKGAMEESGAVLIKRYAFDPQKHAAYINKILSRF
                     ENPYLHDDVERVGRQPLRKLSAGDRLIKPLLGTLEYQLPHDNLITGIAAAMSYRSEQDP
                     QAQELVELLAKLGPKATLAQISDLPADSEVVEQAVSVYNAMQDKLTH"
ORIGIN
        1 cggtggttgc agcagcagaa aatggccatt acgcaggaaa aaataatctt ggtgtgtgtc
       61 tgctccggtg ctttgttggc cgcacaagcc gggctactgg atggttatca gtgcaccacc
      121 caccaccatg tgctggagcg gttacgccaa caagcgccgc gagcacacac caaagaaaat
      181 cgcatttttg ttgaagatcg cggggtttac accagtgcgg ggataacggc gggaattgat
      241 ttgtctttac atctgattag tcgctattgc agcccgcaaa ccgcgctgga agtcgcacgg
      301 gagatggtgg tttattttcg ccgctctggc gatgacccgc aactttcgcc ctggttacgt
      361 taccgcaatc acctccatcc ggcggttcac cgggcacaag atgtgatgtc cgccgcacca
      421 caggaggaat ggtcactgca ccaagtcgcg caaaaatccc atgtcagtag ccgccattta
      481 acccgattat tccgcgagca tgtggggatt agtgtccgtg agtttcatga acaattacgg
      541 gtagcagtgg cgatggtgcg tttgcaagaa gggtttaatc tggagcaagc cgcactggcc
      601 gccggatttt cttccgctcg ccagttgcgt cgtgcccagc aacgtgggtt ggctgtaatt
      661 aactgaccaa acgccgccgg tcaatgcgct gtaaccccat agataataat gtgctcagcg
      721 ccaaggcgag cgcaaagaca tagaaaatat ctaatatcgg ataatcagta aaatcataac
      781 catgggtgcg gataaaatgg ataatcagcg cgtggaaacc ataaattgcc agtgaatgcc
      841 ccgccagcca actcaaccag gcgacaggtt tattaaggca gtttttaaac cacaccaata
      901 atgaagtggc agcaataaat accagtgggc cgcaatacat ataaaaagtg tccgcaaaac
      961 tgccattaat tcgcgtctgt ttttccgtcg aaatggcaat aaagatgata ctggcaataa
     1021 ataacaatcc cgcgccccaa ctgatggccc gcccttgcgt attcagcatg cctattgccc
     1081 gccccagcag cgcatacagc aaataataaa aagtatcgcc atagatatag aggtttatcg
     1141 gcagtaactg gaagccatca atggagtatt tactggtttg tgggttggca aacaccgcca
     1201 ataacaggat gacaatcgcc aaatagcggc ctgatgccgg tttaacatta atcagcggcg
     1261 acaccaaata aaccacgata atggcgtaga aaaaccacaa atgataaaac accggctttt
     1321 gcaggatatt catcaatgac gcccagccat tgatatgagt cagtgtcgca atataaatca
     1381 gtgcaatggc gctgtagaaa accagacaga gcccgattcg ggtaaagtgc tttgattgcg
     1441 cgcttttttc accaaaaaac agatagccgg agatcataaa gaacagtggc acacaggcgc
     1501 gagaagctga attcagcaga ttagcaatat cccagttaac ctcaccaacc tgcgcaccgc
     1561 tggtaacata ataagtcgtg gcgtggatca tgaccaccat aatgcaggcc acggcccgca
     1621 gattatcaat ccagccaatc ttattggtca tgcatatttc ctcactacct tacccacccg
     1681 cgccaacata ttaatcccgc aaattatcag gttacaaaca atcaggttgc aaacaatagc
     1741 gtaaatttga atacataccc atagtaattc cccaaagtca ttggcattac agctaggtag
     1801 caagtgataa gctgataccc gtcagtgatg agagggcaag cgcgcagcta gctccgctgt
     1861 caccacccag gaggaagggt aattgttgct ataaggttat attggcggca gaatagccat
     1921 cccaatatgc tctggctgca catcccgtct gagcaacccg tttttttatg tttactatta
     1981 atagcttaac ctatgcaaac ttcattttca cccgcgacgc gtttaggtcg acgggcgctt
     2041 ttatttcctt tgtgtttagt attgttcgaa tttaccgcgt atatcgccaa cgatatgatt
     2101 cagccaggta tgctggcggt agtggccgat tttaatgcca gtgttgaatg ggttccgacc
     2161 tccatgaccg cgtatctggc cgggggtatg ttcctgcaat ggctgctggg ccctttatcg
     2221 gatcgccgtg ggcgacgccc ggtcatgctg gttggtgtcg ccttctttgt ggtgacctgc
     2281 cttgccattt tgctggtcaa tagcattgag cagtttatcg ccatgcgctt cttgcaaggg
     2341 attggcttgt gctttattgg cgcggttggc tacgccacca tccaggaatc atttgacgaa
     2401 gcggtgtgca ttaaaattac cgcgttgatg gcaaacgtgg cattaatcgc cccgctgctt
     2461 ggccccttgg gcggcgcggc gctgattcat gttgcgccgt ggcagacaat gtttgtgtta
     2521 tttgccgtgt tgggtgcaat ttcatttgct ggtttgtggc gcgccatgcc ggaaaccgcc
     2581 tcacggaaag gagaaaaact gtctgtgggg gccatgtggc acgactataa gttggtgctc
     2641 gctaaccgcc gcttcctgtg tggttccctg gccctgggtt ttgccagcct ccccctgttg
     2701 gcgtggattg ctcaatcccc ggtcatcttg atcagtggcg aacagctctc gacagttgaa
     2761 tatggcatct tgcaggtgcc catctttggg gcgctgatta ttggtaacct gactctggca
     2821 agattgagcg gtaaaaccag tattcccaag cttatccgct atggtgccgg cccgatgctt
     2881 attggcctga tgattgccgc cgcctcaaca ctttattcat cccatgctta tttgtggatg
     2941 acggcagggc tgagtcttta tgcttttggt attggcctgg caaatgcggg tttggtgcga
     3001 ctcactctgt tctccagtga tatcagtaaa gggacagtat ccgccgccat ggggatgata
     3061 agtatgatgg tcttcacctt ggggattgag ttcgccaaag tcgcttacct gtggggcaat
     3121 agcggcgtat tcaacttgtt caatttgatc agtggcttat tgtggttgag cttggtagca
     3181 atatttattc gcaaacagcc ggaaacacta gcagcagagt aatgcaaaga tggtctggtc
     3241 aagttggttt ggccagcata atacaatggc ctccctgttg tagatattga ggaacagcca
     3301 aaacgccagt tagggtttct ggcgggtaag gtttcttgcc cagataattt cgatgatgaa
     3361 gacaaggctg tcattaatct gtttggagct aaggatgaaa atgatttatt tacttgatac
     3421 tcatctggct tgctgcccaa cctgaaaaac gcaacaagga agtattgaaa agatagaaat
     3481 tgatcctgaa atgttacgca acatgttgtt taacaatggt tttacagaat caatcttgaa
     3541 aggggagcag gtgctcaata ccctgaaact ccccgatatg catcaaaacc cttgtggtcg
     3601 agttttagtt tcgcaagcca gagtagaaaa ttaccccctc attactgccg ctagcaaaat
     3661 cattgatagt gctagcggct atgtaacgat gattaataat taaacaaatt attctcggtg
     3721 cggctcgatt ttagatctca agctattgaa gaaaataatc cccggtcgcg cagtagatgg
     3781 tcattacccc gacgccgggt aaatccactg cggtcaaaga attccaggat ttgaattgcc
     3841 agtttgcggc caatgccaag ccggtcacga aaatcagcag cactggcgct accttggctg
     3901 gcatccagct cacgaattaa atccgcaaac tgcgtaatgc gctgactcag ataatagcgg
     3961 tctgggacaa tggcggtaat gtggcccagt tgcgccgctt ttcgtaacaa gttgcgcatc
     4021 tcagcttcat ctatttgcag tgtcgtggcg atatcacgaa cccaccacgg agaatcccca
     4081 aagtgggggg caacttgctg ccataacagc tgttcctgtt cagtaaatgc cagcccgtgc
     4141 tgcgggagat gcagccagcc acgggtattt tttaattccc ccagagccaa caggttatca
     4201 attaaacgaa ataccaggcc ttcatccagt gtcggcaatg ccatacgccg tagccgcgcc
     4261 cgccctagcc ccatttggtc gccatgttgc tgatgataca gacataaaac atgcaataag
     4321 gtttgctggg cttgctgagc atgagggagt gacagcgcga tatcacctgc cacaacacta
     4381 tcagtgctgg ccagtaactc ggcggtgtct tggcctgtaa gctgacgtgc ccaactgaat
     4441 cgggagaccg aaaccggccc ttgcgacaaa tgtaatccca agatttcacg acaatttttg
     4501 gcttgtgcca gggcagttaa ccacgccaaa aatgccggtt ggcgtttacc ccgtttgggc
     4561 accgccagat ggataacccg cgccccgccc aaggtttttt tcgccgcaat atcccgtaga
     4621 atcagccggt cattttcagc cagccagagc ggggtatcca gcagcaattc ggccagtatt
     4681 aatggggatg tggcatcagt ggattctaga ttaatagatt gtgaactaat ggattgtgag
     4741 ctaatggatt gtgggttcgt cagtagcgaa aagcgcccag taatatgact agcggcatga
     4801 tgtatatgca gaggctgcca atgttgtatc ggcgtatccg catcaacggc caccaacacg
     4861 cggtcaaggg cctctggcgg ctgttgcgct aatagccagt cgccacggtt aatctgttgc
     4921 ttactgatat cgccgctgat attcagagca atacgctggc ccgcctgcgc ctgttgcgtc
     4981 ttttggtttt gggcatgaat tcctcgcact cgcacagggc aattaccgcc ggtgagccat
     5041 aaggtatcgc ccaccgccac ttgccccgcc aatgcggtgc cggtcaccac taaaccggca
     5101 cctttcacac tgaatgcgcg gtcaatagcc aggcggaaac gccgctgcaa ccgaccatta
     5161 ttttcatctt gctgatgaca ttgcgccaaa tgttcgcgca attcactgat accaaggccc
     5221 gtggtcgccg ctgtgacaaa cacagtgacc tgctgcgccg accagccttg cgcggccagt
     5281 tcggccatca cctgctggct tacttgcgca atgcgctcgt catcgacagc atctgctttc
     5341 gtcagtgcga cagtcagggt cggatgccca cttagccgta aaatagccag gtgttcacgg
     5401 gtttgcgcca tcacaccgtc atcgccggcc accaccaata aggcatggtc aataccgccc
     5461 acacccgcca acatattggc taagaacttt tcatggccgg gtacgtcaat aaagccaata
     5521 atattgccgt caggttgcgg ccaataggca tagcccagat caatggtcat cccgcgctgc
     5581 ttttcttccg gcagacgatc tgcatttacc ccggtaattg cctgtaacaa tgtcgttttg
     5641 ccgtgatcga catggcctgc ggttgcaata atcatggtgc taactcctgg agcagtgcgg
     5701 cttcattctc aagacagcgc aagtccagcc ataaacgtcc gtcggtcacg cggccaataa
     5761 tcggtttagc caaaccacgc cagcgctcgg ttagcgccgc caaagtactg ccactgccgt
     5821 ctttgggggc aaaagtcacc gcccaactgg gtaatctatc taccggtaat gaaccactcc
     5881 cgatttgtga ccaacacggc tcgaccgcca gggtaaaatc agtgtcatag ttgcctgcca
     5941 gtgcggccag cacccgttgg gcgctctcgg caatggcctc tgccgggcga gtcagtaacc
     6001 gcatggtcgg caacagttcg gttagtcggt ctggttgctg atacagacgt aaagtggcat
     6061 ccagtgcggc tagcgtcatt ttatcggcgc gaagcacccg tttgagtgga tgctgctgta
     6121 attggtcaat ccactgtttt ttaccgagaa taatccccgc ctgagggcca cccaagagtt
     6181 tatcgccgga gaaagtcacc aaatcgaccc cagcggctat caattgctgt ggcatgggtt
     6241 ccgccggtaa accatagcga gtcatatcaa ccagtgagcc actgcctaaa tccgtcgcgg
     6301 taggaatcgc aaactcatgg cccaaggcga ccagctgtga ctctgccact gaggcggtaa
     6361 agccctcaat actgtaattg ctggtatgaa ctttcatcag cagacccgta tgttcactga
     6421 tggcctgacg ataatctttc agatgagtgc ggttggtggt gcccacctct accagttcac
     6481 aaccggcttg gcgcatcaca tcaggaatcc gaaaagcccc gccaatctct actaattcac
     6541 cgcgagaaac gaccacctgt ttgccagcag ccatgacgct gagcatcaga aataccgctg
     6601 cggcgttatt attgacgata caagcatctt cagccccggt aagttcacag agcaaatcgg
     6661 caaccgcccg atcacgatga ccgcgccgcg caccatccag cgaatattcc aatgtcacag
     6721 caccgcgcat cgcgtcattc acagcggaaa tggcagattc agccaagggg gcacggccta
     6781 aattggtgtg caaaacagta ccggaaaggt taaagacagg ttttaatgcg ggctggcgtt
     6841 gattcaatcg ttgacgtaaa gcagcgggcc aatcggtgca ccaatccgcc agagtatcaa
     6901 attggcgaat atgctcacgg gcctccagct gtaattttct caaggtttcg gtcaataaaa
     6961 cagggccata ctcggccagc aatgttgcca tttcaggttg gtgcagcagg cggtcaattg
     7021 ccggtaactg gcggtataac agatgtgatt ctgcgctcat agtcactcag gtattagtga
     7081 tagtgaggtc aaaaaagccc ccaacaaggt cgggtactct gacgaattaa ttaatgccac
     7141 acgattcatt tagctgcgtt ggacactaac acttagtagt aaaagttgac tcgttagcca
     7201 tcaaccaggg tgcctattta ccctaacagg gtcagattct gatactgcgt acagccactc
     7261 ggtaatggct ttttatctgg cggcacaggg gtaaccttac catcaaatag gtttatctgc
     7321 cgttaattgg cggaaagttt agatcaagat accccagctg gcgaagaact gtgcgccatg
     7381 ttgagctaat cactcgcacc cattgttatt acaaagaaaa acaatggtgc aacccatggt
     7441 cgcactcatc gcagccgcca acctgaccgc cgcgcagcgg atagtgtcaa tttaacatca
     7501 cacttatctt tcacgccttg ccaagataat ttgatggatg gcgctataca ggtctttaaa
     7561 tatggaataa tatcgccaca aatttagcta tattgaagat ttgttgaaca tacggcctgt
     7621 atgttagtca gaaaaatcaa taggatgaag ataatagcat gagtgctcct actccctcct
     7681 aacaatcagc aaaacgctca gaaaacctct attatttgta acaatatatc tgaagagtta
     7741 ttagatattt tagacgtcgc aattatttta aattattaaa gaaatgaaaa catttacttt
     7801 aattattagc gagttgaatt actgagaata tttataatga aaattgcaat agcgggtata
     7861 ggttatgtcg ggttatcaaa tggtatcttg ttgtcacagc atcatgaggt cgtggcctta
     7921 gatatcattc cagaaaaagt ggagatgctg aaccgtagag aatcggtcat cattgataca
     7981 gagctacaag attatttaca aaataaagcg ctaaatttcc gagctacgct agataaacgt
     8041 gatgcttatg aaggcgcaag ttatatcatt attgccacac cgactgatta cgatcctgaa
     8101 aagaactatt tcaataccaa atctattgaa gctgtcattc aggatgttat ggcgattaac
     8161 cccgatgcag taatgattat taagtcaact gtacctgtcg gctatactgc taaaaccaaa
     8221 gaaaaatttg gctgtaataa tctcatcttc tccccggaat tcctgcggga agggcttgct
     8281 ctctatgata atttacaccc ttctcgtatt gttgttggcg agcgctccga gcgggcagag
     8341 gtctttgcta atttattaaa agaaggcgca attaaagaga atataccgac tttatttaca
     8401 gattccacag aagccgaggc aattaaactc ttcgctaata cctatttggc gatgcgagta
     8461 tcttatttta atgagctgga tacttacgcg gcttcacatg gcttagatac ccgccaaatt
     8521 attgatggtg tctgcctcga ccctcgaatt gggccacatt ataataatcc atccttcggc
     8581 tatggcggct actgcttacc taaagatacc aagcaactct tggcaaatta caaccatgtt
     8641 ccgcaaaatc ttattaatgc cattgttgcc tccaatacca ctcgcaaaga ttttatcgcc
     8701 gctgatattc taaagcgcaa ccccaaagtt gttggtgtct atcgcctcat catgaaaagt
     8761 gggtctgata acttccgggc gtcgagtatt caagggatta tgaagcgcat taaggctaag
     8821 ggcgttgaag tcattatcta tgaaccgaca ttacaagaaa ctgagttttt taactctcgt
     8881 gtattaactg atttagataa gttcaaacaa gagtccgata ttattatcag taaccggatg
     8941 cttgatgtat taaatgatgt aaaagataaa gtttataccc gtgatttatt tggtgataac
     9001 taactcgtta ttatttgatt gtgctgaacg acttttttat cttcagcaca atcaatatta
     9061 ataaacccgc attattcccc tgggaacaaa aacggattaa tactgctgcg agcaaaaccc
     9121 tcgccttcca tcttagcatc gagaatcagc gaggctaagt catccgccac agcttctacc
     9181 tgcggatctt tttcctgata taaaattttc aggtaagtgc cacaatcacc acagctttca
     9241 gccttcactg ccgccaattc gctgtccagc gaccaataat tcaaatcacc tgtctgctcg
     9301 cagttgctgc acttaatccg caccacatgc cactcgcttt cacacaaatt acagtgtaaa
     9361 tagcgcaagc cattgttagt gccaatatgc accacactgg ataccggaat actgccgcat
     9421 acagggcaaa attggcgatg ttcgccatat tcagcccgag ctttccctgg gatttggctg
     9481 gccatttgcg cccaatacaa tgacagcgca gcccagataa atggcgcttt ttcgctgcca
     9541 atcttcgcaa actcgcggtt tagcagagca tcggcgtaca gctccagctc atgtactgaa
     9601 gacttatcca gattatccag caccgccaca atatgatctg gtgcctctgg gcgtaactcg
     9661 gcaatcagcg ctgacaacag cttgcgccag tgctctgttc gcggaaaaac actcaaatcc
     9721 agtggcggct taccgctaat cgcagattgc tccagctcag cttgcatatc caacaccagc
     9781 ggatggtcat gcagtgcttt ttgctgtgct tgggtaattt tagccgcaaa atccagataa
     9841 tcagccagcg ggttatccag cgctaactgc tgcaaacgtt cggttcgccg ggtatacaag
     9901 ctttttaaat tagcgaaaag taacggcggg atattccccg ccgttgaacc tttttcgctt
     9961 tgttttccta attgatcttt agggacaatg cgaatactca tcagggtttc tcttcctgtc
    10021 ttttctgacg cttactttca acctcacgat accagcgcgg atggtgcttt ttagcccatg
    10081 ctgccggtac ccaaccttcc accatcgcgg taatcgtgcc tttcacccat agggcggcat
    10141 agatatgcac cataatcacc aggattaacc ccaccgccgc cagcgaatgc accagcagtg
    10201 ccaggcgaat cagcgggatc gggaaagagg gcgcaaagta aggccgccaa ataaccacac
    10261 cactggccag tagcagcacc agactaataa tagcagccca aaatacacac ttctgaccga
    10321 aattatagcg cccagtatcg cccacttcct cattcatggc gattttgtgg atattttttg
    10381 cccactccag gtcttccttg ttaatcaggt tatgcttcca gtaacggaaa aacatgatga
    10441 ggaaggccgc gaacataatc acccctgcga aggggtgaag gatgcgcgct agctggggag
    10501 taccaaaaat attcatcaac cagttaaatg acgggaagaa gaaccccaag ccactgatag
    10561 ctgccagcat aaagcagaag gcgactatcc agtggttgat tcgctccggc gcactgtagc
    10621 gctggatccg cttttctttt ttcatttccg cgtttccccg tcgtctgagt gctcagcggt
    10681 agtctgctct ggcgccttag atgcggtatc agaaggcgtg gaatctgatt tatcgtcttc
    10741 ctcctcttct tcctcaaccc ggttcgggcc gacaccaacg taatggaaaa tactggcagc
    10801 aaaggtggcg gcaaaggcta ccgccgccag tggtttccag acgcctttcc agaaagtcac
    10861 ggtcgggctg atggtcgggt tttccggcaa gccatgataa agctgaggtt tatccgcatg
    10921 atgcagaaca tacatcacgt gggtaccacc gacacccgca gggtcatata acccggcgtt
    10981 atcaaagcca cgggttttca gttccgcaac tcggccagca gccacttctt tcatcgactc
    11041 tttagtacca aagtgaatcg ccccagtcgg gcaagttttc acacaagcag gttcctggcc
    11101 aacacccacg cggtcgacgc acagggtaca tttgtacacc cgattatcgt ctttattcat
    11161 gcgcggcaca tcaaacgggc aacccgcgat gcaataacca caaccgatac aatgctctga
    11221 ttggaaatcg acgatgccat tggcatactg aattattgcc ccttccgacg gacatgcctt
    11281 caggcagcct gggtcggcgc aatgcatgca gccatcctta cgaataagcc actccagctt
    11341 gccgttttcc tcaacttcag agaagcgcat caccgtccat gatttggcgg tcaaatcggc
    11401 ggggttatcg tacaccccga cgttgtaacc gacttcatcg cggatgtcgt tccactccga
    11461 gcacgccacc tgacaagctt tacaaccaat acaggtggtg acatcgataa gcttcgccac
    11521 ctctgcctgg aaattacgat cctgcggcgg cggcgtcagg gagttggtgc cggagcgcct
    11581 gataatgtct tgagattgca gtgacataga ttctctccgt tacacctttt ccacgttgac
    11641 caagaacgcc ttaaactctg gcgtttgcgt attagcatca ccgacaaatg gcgtcagtgt
    11701 attggccagg aagccttttt tcgccacccc ttcaaatccc cagtggatcg gaataccaat
    11761 ggtgtcgact tcttgtccgt tgacattcag tgtgcgaata cgtttggtca ccactgcctt
    11821 ggccttgata tagccacggt tagagctgac ttttaccgta tccccatgct ggatgccctt
    11881 tttcgctgcc agtttttcgc caatttctac aaactgttcc ggctgcataa tggcattaag
    11941 caatgcatgc ttcgtccagt agtggaaatg ctcggtcaga cgataagtgg taccgacata
    12001 tgggaattgc tcatgagaac ccatcgtggc caaatcgtct ttaaagacgc gggccgccgg
    12061 gttggatatc acattcgggt gcagtgggtt ggtgcccaat ggtgtttcga atggctcata
    12121 gtgttctggg aacggccctt ctgccatttt atcaatggca aacagacgcc ccatcccctc
    12181 aggctgcata ataaatggcc cgacatcact gcccggagga gctgcgctgt agtcagggac
    12241 atcaatgccc gtccacttcg ctccatccca ctccagcaac tgacgtttcg gatcccaagg
    12301 tttaccctgc gggtcagcag aagcacggtt atacagaatg cggcggttaa gtggccatgc
    12361 ccatgcccag cccagcgtgt tacccaggcc tgatgggtcg gcgttatcgc gtcgtgccat
    12421 ctggttaccg gctggcgtcc agctacccgc aaatatccag caaccactgg cggtggtgcc
    12481 gtcatcacgc agatgagcaa aggtgctaag ctgctcgcct tttttgacca gcactttgcc
    12541 atcggcgtca gttatatcag ccagggcgcg accattactt tccatcgcca cttcttccgg
    12601 ctcaggattt tctggtgtca ggtaatccca ggtcatattc agcacctgtt ctggcaccgc
    12661 accgccttcg cgctgataca tttcgcgcag acgcaggaag ataccggcca aaataccacc
    12721 gtcattcatg gcttcgcccg gtgaatccgc acctttccag tgccattgta gccagcgacc
    12781 agagttaacg attgagccat tttcttccgc aaagcaactt gatggtaagc ggaatacctc
    12841 agtttgaatt ttcgacgaat cgacgtcgtt aaactcaccg tggttttgcc agaagttcgc
    12901 agtttcagta ttgagtgggt caatagttac caggaacttc agtttcgaca gtgccgctac
    12961 cactttgttt ttattaggga aagaagcaac cgggttaaaa ccctggcaca gatagccatt
    13021 cactttaccc tgcgacatca tctcgaaata ctgcaagacg tcgtagcctt tatcccactt
    13081 cggcaaccag tcgtagcccc agccattttc cttctgtgct ttatcgccat agaagctctt
    13141 catcatactg acgaagaatt tcggataatt gctccagtag tttacctggc ccggcaacaa
    13201 ggttttcggc gtgttggcct tgaggtaagt ttcaatatct ggctgtttct cagacggcag
    13261 attcatataa cccggcagac tttgcgacag caagcccagg tcagtcagcc cctgaatatt
    13321 ggagtgaccg cgcaaggcgt tcacaccacc acccgccatc cccatattgc ccagcagcaa
    13381 ctgaatcatt gccatagtgc ggatgttttg cgcgccaact gagtgttgcg tccagcccaa
    13441 ggcgtacaag aacgatgcgg ttttatctgc agcactggtt tctgcgatat attcgcaaac
    13501 cgtgatgaaa tcttctttcg gtgtgccaca gatattagac accacatctg gcgtgtagcg
    13561 gctgatatgc tctttcagca agttccacac gcaacgtggg tcttgcaggg tgacgtcgcg
    13621 tttcgcaaag ccattttcat ccaactggta gttccagctg gttttatcgt atttacgatt
    13681 atcggcgtca tagccgctga acaaaccgtc ttcgaaggta aagtcttccc gcaccagcaa
    13741 gctggcgttg gtataggctt cgacgtattc gcggttaatt ttttcgttgg ttatcaggta
    13801 cagcaagaca ccggatagga acgcgatatc agtaccggag cggattggcg tataaaaatc
    13861 agccaccgac gcagtacggg taaagcgcgg atctatcacg atcagcttgg cattgttgtg
    13921 gatcttggct tccatcgccc agcggaatcc caccggatgc gcttctgccg cattaccgcc
    13981 catgacgata attaaattcg cgttcttgat atcaacccag tggttggtca tcgcaccgcg
    14041 accaaatgtt ggagcaagac ttgctaccgt tggtccgtgt cagacacgtg cttggttgtc
    14101 tacggcaagc atgccgagag cgcgactaaa tttctgggtc aaataacccg tttcattact
    14161 ggatgccgaa gcacacagca tgccggtact cagccaacgg ttgacggtaa caccggcgtc
    14221 gttggtctca ataaagttag catcccggtc ttctttcatc agcttggcga tgcgcgtaaa
    14281 agcatcatcc caactgattc gctgccactt atcggaacct ggcgcgcggt attctgggta
    14341 tttcaggcgg ctttcgctgt ggataaagtc caccagcccc gcaccttttg gacaaagtgc
    14401 accacggttt accgggtgat ctggatcccc ctcaatgtgg aaaatactct ctttggcgtt
    14461 tttcgcaccg tcgcccaggc tatacatcaa aagcccgcaa ccgacagaac agtacgtgca
    14521 ggtattccgc gtttcacggg cgcgcaacaa tttatattgc cgcgtttccg ctagcgccac
    14581 tgacggcgta aagccgagtg ccgcgaccgt ggttcccgcc ataccgccag cgcagatctt
    14641 aaagaactgc cttctgctga cctgcatggg tctctccttc atttcacgat tgtcacaatg
    14701 ctttaccctt aatactccga gctacatggg cgttggctgc tctcactaac ccgaaacact
    14761 tgcttaagta agctcatcgg gattaattcg cttgccgcct tcctgcaact caaattattt
    14821 tgggtatgaa tttaaaattg agttcgcgct tccctcaacg aaatgggagg cgctaaaatc
    14881 gcttatgcga tatccagctc gtcagtgtga gatacattcc tttaatagta gaatatagcc
    14941 acaccattct taatgtgaat gttaccacat tgtgactatg ggttataact ttcaggacaa
    15001 catagtgagc cagatcaaac cgtcaacaac tgactttccc accgaaattt gcggtgccaa
    15061 gcaacttaac gtgctacagc gccatcatat ggcagagcca cagcgggatt ggctggctga
    15121 agaagtacca gtagcactgg tgtacaacgg catttctcat gtcgtgatga tggcaacccc
    15181 caaggattta gaggccttcg ctctaggatt ttcgctatcg gaaggcatta ttgccgcacc
    15241 acaagaaatc tatgccattg atgtcacccc tggctgcaat ggcatagaag ttaatattga
    15301 actatccagc cgccgttttg ccggattgaa agaacgccgc cgtgctatgg ctggtcgcac
    15361 tggatgtggt gtctgtggta ttgaacaatt ggatgatatt ttccgaccaa tcacgcccct
    15421 gccttttaca caaactttta accttaatca cttggatagt gcgcttgcgc aactcaaaca
    15481 ggtacaaact gtgggccaac tgacgggttg cacccatgct gcggcctgga ttacacctca
    15541 aggggaatta ttgggcggtt gtgaagatgt tggccgccat gtggcgctgg ataaactgct
    15601 agggattcgg gccaaacagc cgtggcagca aggcgcggtg ctggtttcca gccgtgccag
    15661 ctatgagatg gtgcagaaaa ccgcgatgtg cggtgccgag attttatttg ctgtttctgc
    15721 tgccacaacc ttagccgttg aagttgcaac tcggtgtaat ctcaccctgg ttggcttcag
    15781 taagcccggt agagccacag tgtataccca ccctcagcgc atcattgaat agaaaagcca
    15841 catagttagt aaggaattga taatcatttt caatatcatt taattaacta taatgatccg
    15901 aatgcttacg cggtgcttac tttttttgca ccgccctaca cctatggaga cgatgattat
    15961 gagttactca ctgccatccc tgccttatgc ttatgacgcc ctggaaccac atttcgataa
    16021 gcagacgatg gaaatccatc acaccaaaca ccaccaaacc tatgtaaaca atgcaaacac
    16081 ggtgttggaa gcctacccgg aactggcaag ctatagcgtt gaagatctta tcaaagatct
    16141 ggacaaagtc cctgctgaca agcgcacctt tatgcgcaat aacgccggcg gccatgctaa
    16201 ccacagcttc ttctggaaag gcctgaaatt gggcactagc cttggtggcg atctgaaagc
    16261 tgctatcgaa cgcgatttcg gtagcgtaga gaaattccag gaagaattcg aaaaagcggc
    16321 tgcgacccgt ttcggttctg gttgggcttg gctggtattg aaagacggca aattggcggt
    16381 agtttctact gctaaccaag acagcccgtt gatgggtgaa gcggtttctg gcgcatcagg
    16441 cttcccgatt attggcctgg atgtttggga acatgcttac tacctgaaat tccaaaaccg
    16501 ccgcccagac tacatcaaag cattctggaa cgtagttaac tgggacgaag cagcagcccg
    16561 tttcgctcaa gctaagtaat tcggatacgt ccgcatagct aacccctacg gcttcaagcc
    16621 gcagggtata aatgccagta aggtgacctt gctggcattt tttattgcta aagtttagcc
    16681 aatttctgcc gatagattgt actaagaagg ttactggcat ttatggcgtg aatccatgag
    16741 tgcagttata acaacgtcgg ggaattgtac tcttgccaag actcccccac gttcaatcag
    16801 tccctttcac ctctctaata ataagacctc caaaactcac ctacgctgat tgatttgcag
    16861 cataaacact gcataacgga gaagaacatg gcagcattta gcaaagtttt cggtaacttt
    16921 gaaaacgtga aagtaggtaa aaagctggga ttaagctttt ttctgatgtt gttgttagtt
    16981 gggattatcg ctggaacgac tgcttatcat ttttctgcca ttgaaaaaca tgcttataaa
    17041 gtcgatctaa gctacaaaat taatgatgaa gccaatcagg caaaatataa ccgtgcgcta
    17101 tatgaaagaa cttatgacct gaaatatata aaagaaaact ctgaacatat taatgaaata
    17161 aaaagcctgc tgactgaaag tgagaaactt agttggtcgg cagaaaacca taaaataatt
    17221 aatagtatta gtgatatcgc tgaagaatac ctgcaacagc aaagtaattt tgtcaatgca
    17281 gtggcccata aagacgatgt gcgaaaaagt tggaatattt ccgaaaccca gaaaaatctc
    17341 aatgagttac agcaaaattt tctcaatgaa ggggcggata ccaacaccca aattctgttg
    17401 gcggaaatga accagaagtt aatgaccgtg cgctataacg cccgtggttt attgctggat
    17461 cgcaaccagg aagcagaatc ttcgctgatc acctccatca atgttgccaa cagcgcagcc
    17521 aatgccttta tgccggtttt atcagccagt cagcaacagc taatggcccc ggtaatctcc
    17581 agcctcgcca cctataaaga caatgtgctg gcctatttac cggcatatcg gcaagagctg
    17641 gaagtgggta aagtgatgga agccagtgcc aatgaattga ataagctcgc gacccagttg
    17701 ttcacccaag agctgcaagg tacccacctc gaaattaata acgcgcaatg gttattagca
    17761 attgcggccc ttgcagcctt gctgtgtggt ttgctgattt catggcgaat gacccgccag
    17821 ataaccctac cattgcgcac cacactggca atggctgaac gtattgctac cggtgattta
    17881 accacggcga ctaaatcaaa tcgtactgat gaattaggtt tgctgatgaa tgctgtcgcc
    17941 cggatgaatg aaaatctgcg cgctatgatt gatgacattc gtgttggcgt cagtcaggtg
    18001 tctcatgcct ctggtgaaat tgctgccggc aatacagatt tgtcctcgcg cactgagcaa
    18061 caagctgcag ccgtagaaga aacggcggcc agtatggagc agctgaatgc cacagtgaaa
    18121 cagaatgccg ataatgccca ccatgctaat caactggcta ccgaggcctc aacaaccgca
    18181 caacagggcg gcaagttagt tagcgatgtc gtgcgcacca tgaatgatat ttctggcagt
    18241 tccaaacgaa tctctgaaat tacctctgtg attaatagca ttgctttcca gacgaatatt
    18301 ttggcactga atgccgcggt tgaagcggct cgtgccggcg aacaaggccg tggttttgcc
    18361 gtggtagcca gcgaagtacg taatctggca caacgcagtg cacaggcggc gaaagagatt
    18421 gaggggctga ttggtgaatc ggtatctcaa gtgagtgcag gaacgttact ggtacaaaat
    18481 gcggggaaaa ccatggatga catcgtccgc tcagtcactc acgtgcatga tattatggca
    18541 gaaattgcct cagcctctga tgagcaaagc cgtggtatca cccaagtcag ccaagccatc
    18601 gccgaaatgg acagcaccac ccagcaaaat gccgccttgg tggaggaatc tgcggcggcg
    18661 gcagactcgc tggctgagca agctatctta ctggcacaag cggttgccgt gttccgattg
    18721 tccgagtcag aggcagaaac tccacaacat caacatgctg aagcggttat ggctcggcac
    18781 gtcagcgcct ctaacagcac agcagcgcgc caaacttcag aaactcgtca aaataatcaa
    18841 caagataact gggaaacctt ttgaccgatg gctaaacctt ggaaccctgc catcaggcag
    18901 ggtatcctga ctctcccagc ctgatgcaga tgaggagaac agatgaataa tccacaggta
    18961 tatatcggta aaatcgaacc ttatagcggc agttcgccca gtgcgattgg caaacgtcag
    19021 gtgcagggtg ggattatgct cacgccgctg gggttagagg gcgatgaaca agccgaaacc
    19081 cgctttcatg gcggcccgga tcgcgcctta tgccactatc cacgcgagca ttatgcttac
    19141 tgggcgcagc agttccctga gcaagccgat atcttctccg caccggctta tggcgaaaat
    19201 atctcaaccc tcggtatgac agagcaaaat gtacatatag gggatattta tcgttggggc
    19261 ggtgccatca ttcaggtaac ccaaccgcgc tcgccttgtt acaaactcaa cttccatttt
    19321 gccatcaaag atatgtcggt gatgatgcag caaaccggtt actgcggctg gctgtatcgg
    19381 gtgatttcgc ccggtaaaat cagcgaaagt catccattag cattattagc acgaaccagt
    19441 gatatctcgg tatctgaagc catcgccatt gcctggcata tgccatttga tgaagaacaa
    19501 tatcgccgtt tattggcagc tgcggggtta tctgccagtt ggagcaaaac catgctgaca
    19561 cgcattgaag aagggaaaat cgaagatttt aaccggcgtt tactgggaaa tagctaggta
    19621 ttaagggggg tcaggcaata ttgctacttt cgcgaatgcc atatcggagg gttttttttg
    19681 ctcatctaca aactaagtag ccctacccag atgagccaaa ttgtttttgt ccgcactggg
    19741 acacattcaa aattatccga ttaaactctg acaatagcca atcgggtggc agcaatgcca
    19801 cacacccgaa ttgattgagc gcagcgatca aaacgctttt ttggcgtaac cggtcacttc
    19861 cttcaagccc atttcacggc ctaatgcggt cattgggtgc actaccacaa taccacgcac
    19921 ggcttttttc aaggtgccca tatccgcttg ctcttttttg gtaattgggc ggctaaaggg
    19981 caattgagcc agtttttgcg cttctgcact caggtttttg actcgcactt ctttcaaacg
    20041 ctgaatttca acggccagtt tttctttttc tttcatatgc tgcgcgatta aatccacatt
    20101 accctgctgg ataacagcgg gatctttgtg gttcatggca tccagcatgt cgcttagacg
    20161 tttgatttct gcatgttctt tcatagtatt ggcccgtaca tgccgctatg ggcacgatat
    20221 ttcactaaag ttggcgatag aatagcactg attgtgcatc aagatagata gtgtatcagg
    20281 gtgtttgctt ttcggcagca acctcctgta acggctgcca ttgcattcct gccggtagcc
    20341 cactcatttc acaggcaacc gcccctaacc gctctaatgc tccggtatag cggctgttga
    20401 atggataaca gcaggataag cgaaaagcat tacgataacg gccacttggc gaatacagcg
    20461 tgcctggcgt caagcaaatt tgctcctgca ataattgatg aaatagcgcg acagtatcga
    20521 caccggccgg aaattccacc caaaagacaa acccgcccgc gggctgtgtc actgtggtgc
    20581 cacgggggaa actgcgggta atcaattgct gggccagctg tacctgctgc gcatagcggc
    20641 ggcgcaaact gcgcaagtgg tggtcatagc caccggattc cagaaacagt gccagagttt
    20701 cggataacaa tgcgggctcc gccatcgacg ataccgcttt tagcttatgt aatgcttcag
    20761 caaagcgccc accgtcaatc cagccgacac ggaaatcagg tgccagtgtt ttggtaaagc
    20821 tggaacaaaa cagcacccag ccgtcacgat caaatgcttt tactgccgga gataatgtcg
    20881 taccaaattg aatttcggca tataacccat cttcaattaa tggcacttgg tgatcgttca
    20941 tcagctgtgc cagtcgtttt ttcgccgcca gcggcatagt gtaccccata gggttctgta
    21001 ccgttggcat ggcaatcaga gcatttaacc gcccttcctc gagtagcaat tccagcacat
    21061 ccagcgataa accctgctgt ggatctgtgg gaatttccac cgcttttagg ccgaggctgg
    21121 ccagcaatgg catgagataa aaatatgtcg gtgattccaa cccgacacaa tcccccggct
    21181 tagtggtgac ccgcaatgcc aattgcagcg cctccatgca accatgagta atggtgatat
    21241 cagccgggga agccagcatt cctagcgtca tggcgcggcg agcaatttgt tgacgtaacc
    21301 gctggctgcc agggggtaag gcatattggc tgattaactg cggttctcgg cgtaatagtg
    21361 atgccatgat acgccccaat ttggcactgg ggtaaaaatc cccggtttgc gggcaggcga
    21421 gtgaaatatt agtaaatcgt ggattgcgtt gcgcggcaaa aaccgtatct atcaaatcca
    21481 gcacctcatc caccggcttg ccaacggtgg ccgttggcac caccgccgtc gatgggctac
    21541 agacgtagaa cccagactgc gggcgggcct caatcaagcc ccggtcttcc agcgtacgat
    21601 aagccgccac caccgtattg atactcacct ggtgactttg tgcgtaaccc cgcactgaag
    21661 gcagacgact gcccgctagc agactgccat ttttaatggc ctgcgccaaa ttgtctgcca
    21721 cttgcaaata gcgaatttca ttcataacaa caggcatggt gacagttctc cgcaggttca
    21781 atgggtacag ttctatgtta agcaaactgt acccattaca atagataact tctgcgtcta
    21841 acgccacagc ccattgctgt ttatgctaaa tcccttggca atataattag ttacccaacg
    21901 tcattgggat tgcagaccgg cagcaagtga acaaatcccg atgaacttat ttatgtcagt
    21961 gattcgggtg agtgacccag gctaactgcc ctgtagtttc aagcacgaag ggggcagagg
    22021 aattccccat gttagacagt gcttttatca gttacgttac cgttatgtcg ataacacccg
    22081 gccccaataa cctgttgtta gccgcctctg gcgtcaattt tgggttacgc cgcaccctgc
    22141 caatgatgct ggggattacc tttggctgcg cattacaatg cgcgttgatg accacactgc
    22201 tggcgctgat tctcagttgg gtgggggtta ttcgtctgcc tttagtgaca ttggggggcg
    22261 gttatttatt gtggctctct tggaagattt ttaattctgg cacccccaat gccagggata
    22321 gccagcaacc gatgggattt attcaggggg cattatttca agctattaat ccaaaagcct
    22381 ggctgatggc catgaatgtc gccatattat ttacgccgcg cgaaggggcg acactcagcc
    22441 atacgctgct gattatgacc ggttttgctt tattgaattt gccttgcgtg gcggtgtggg
    22501 cggtattggg tgatcaattg cgccatgcgc tgcgcgtcaa ttggaagttg cggttattta
    22561 atggcgtgat gggcggcttg atggcaatta ccgcattgtg gttgttagcc gatgaatggc
    22621 tcagtgtcgt ccatcattaa atcaggcatg accgagtggc gagagcttgg agacttgttt
    22681 ttgactgata cgggagagca gctcggtgat ggagagcacc atagttgagc gcaccatttg
    22741 ctgataacgc tggcgttgca tggcaatcag caaagcatcg gcttcatctg ggcgtaagaa
    22801 tgtcggcact ggcggcagtt cagccacaca atgtaattca ccaaatggcc cgaggatttc
    22861 atcgtcagta aagcgatact cggtgccatc atggtttagc tcctcgcgca gcgccattaa
    22921 tagctccgca tcctcatatt catgccgggt aatcaccccc aaagcataaa ccaacttcaa
    22981 cctgacagat aactcaccta gcgggccatc tccgaccaat aagggcccca cagcatattt
    23041 caccgcgtag tcatctttac gaaaaacttg caccacgaga atattgagcg cttctgctaa
    23101 taattcgaca gcagccatca ggaaactccg aacggtcttc cccgcgttca gatgttcaag
    23161 tacccgattc tcaaatgcct gtgtttgttc aatcattgtt tatcactgga tatgaggcga
    23221 ctaaaggata aataccgtgc aatccgacac ggtatttatc tgctaacaca accgtcttgg
    23281 ttcttaacgg aatcagtgtg tcagcttgtc ctgcatggcg ttatacacac tcaccgcctg
    23341 ttcgacaacc tcgctatcag cgggcaagtc agaaatttga gcgagggtgg ctttcggccc
    23401 taatttcgcc aataattcaa ccaattcctg agcttgtgga tcctgctcac tgcgataact
    23461 catcgcagcg gcaataccgg ttatcaagtt atcatgtggt aactgatatt ccagcgtccc
    23521 tagcagcggt ttgatcaacc ggtcaccggc actcagttta cgcagcggct gacggccaac
    23581 gcgttcaaca tcatcatgca ggtaagggtt ttcaaaacgg gagagaatct tattgatata
    23641 agcggcatgt ttttgtgggt caaaagcata acgtttaatc agtaccgcgc cgctttcttc
    23701 catcgcgcct tttacagttt ggcgcactgc gggatccaaa atggcatcac ggatagtctg
    23761 gtgacctgcc aattgcccca gatacgcggt aatggcatgg ccggtattca atgtgaagag
    23821 tttgcgctca acaaaggcca tcagattatc agtgagttcc ataccggcga tttccggcgg
    23881 ctgcccttta aactgggtgc catcgacaat ccactcgctg aatgtttcta ccgtcacggc
    23941 cagaatatct gtgctgcccg cttccgatgg cggcacaatg cggtctaccg cagaatcgac
    24001 aaaaccaaca tgttgctcaa cccacgcctg ctcatcttca ggtaacgcgg caaaaacatg
    24061 ctgttttaac tggctggtgc cacgcaccat attctcacaa gcaataatgt tcagtgggcg
    24121 agtattacct tgttgatgac gagtaaccaa accttgggcc acagtgccag caatacgagc
    24181 cagaatttgt gggccaaccg cagtggtgac aatatcagca tcagcaatca gggccaccac
    24241 ttctgggctg ccactgttca ctgcgctcac atttttcact tcttcaacac gcgcttgttc
    24301 gccaaccaca ttaacctgat aactcttacg cttatttagc tcatccaaca ggggttggtt
    24361 aacatcggcg aaagtcagtt gcgcaccggc atcagctaga agtttaccaa tgaatccccg
    24421 gccaatatta cctgcgccaa aatgcaatgc tttcatattc gttacctttt gctgtaaaag
    24481 ggccatttac tcccaatgac ccgattcaga ttgcggtagt tatccggcac caccggataa
    24541 cccctatcac gacacagtta ttacctgttt actttttacc gcccagtaaa tccagtactt
    24601 cttgtacgct ggtcgtttta gataaacgtt caatgacaga ttcatcatcc agcgcattcg
    24661 ttaagct
//
