LOCUS       c00005_NZ_VXKE..       15091 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_VXKE01000005.1 Helicobacter canis strain CCUG 32756T
            contig_0000005, whole genome shotgun sequence.
ACCESSION   NZ_VXKE01000005
VERSION     NZ_VXKE01000005
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-13 23:56:15
            Original ID  :: NZ_VXKE01000005.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 97910
            Orig. end    :: 113001
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15091
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[107910:110612]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..12702
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..15091
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15091
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(753..980)
                     /locus_tag="ctg5_93"
                     /transl_table=11
                     /translation="MKLDTCEYNRSYKVTAINLEDIVAKERLASLGIVIGALITSLQTS
                     AKKATISVQVHQTIIALRSEEARQIEVEPM"
     CDS             1088..1594
                     /locus_tag="ctg5_94"
                     /transl_table=11
                     /translation="MKFLSQFLYQQALATSSKLYYKILLRLRGILLRLCDPLITTTFRG
                     YTLTMPSSHTIFLNQKLYPFYDMRLQTLAQYLCAKDGRLAMVDVGANIGDTAVFSQVDG
                     ASYLLIEGEQTYAALIPANLRANLSAPLSQHTSTQNLECMTTWTTSGFAGGGGTINSSI
                     FARHF"
     CDS             1624..2109
                     /locus_tag="ctg5_95"
                     /transl_table=11
                     /translation="MSLQDGSGKLIASSSQSPIYTLDTIVQKSSFSPNFIKIDTDGFDF
                     KVLRGAIATIKAYAPVIYFEWSYTHLLEQAESPLAIFPLLRELGYLELVIFDNFGTLLC
                     VLPSDDRQNLALLMDYTKDSSQIHYYDVLAIPSQSAFNLQEYLQLYTKQNAQAREWI"
     CDS             2172..4079
                     /locus_tag="ctg5_96"
                     /transl_table=11
                     /translation="MSHFDTNLAALSKVDPLLYLALKSFTPNQNYEVFMDSDPVNYNII
                     DTKNAKALYLTKPIDEIMERNSQLNSYSYYPFLYLYGLGNGVLIRLLFNSQRQRIVVFE
                     PELEIIFIVLNLLDFSKELANKELVIIYTKQIGYMGVDSLFDSNKYSRVFVKTYDLLVA
                     CPYYESYHDDILRINGYFIKAIEQAVVSVGNDAKDSVIGIYNHIANLPDALRTPSLKDL
                     VLALKDRDSAIIVSTGPSLHKQLPLLKQVAPYAVLLCVDASFPILTKHGIKPDIVLSLE
                     RVQESAKFYTDTPKQAQKGVVFALTSIVHKQTKLALKGASVQFSFRPFGYTSLFGFDDY
                     GYLGIGMSAANMAYELAMLAQFKQCIFIGQDLAFGDDGSSHSKDAIYGTQEAQYKKEGI
                     FVPRYGGEGEIETSKIWKLFLHFFEKDIARTSPNMEVINATEGGARIVGTKELPFKQVV
                     ESIVQKAQTKSPITLPQVPTKQSEKNIKKAYKKVQDIIKYGSVQKRKIERVFLQLAKEL
                     EHIEKLNTQNKLEKINFTKLDSLSDKIDSIKQLFNERKFTSYFMDAIQSYIFHQELDIA
                     KVLVLYTANEEEMKAKQLQWLYYHKYWLFSLAGGIDCVIHTAQKALDEWSKQDLALAKS
                     "
     CDS             complement(4303..5370)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CbiA"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_97"
                     /sec_met_domain="CbiA (E-value: 4e-17, bitscore: 55.3,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQTTITKLLSQVLYPNFEKDIVSYGFVKEIKLDGGVEVVVAIPSS
                     DPNVAKALYDRIDNVLQKANIQAVITIKTPELQAESKAAPQARNLLPQVKHFVMVSSGK
                     GGVGKSSVATNLAIALAMDGKKVGLLDADIYGPNIPRMFGLHGIKPKLDPSGKRLIPLQ
                     AYGVDLMSMGMLFDEGESLIWRGPMLMRAITQMFSDVVWQDLDVLVLDMPPGTGDAQLS
                     IAQSVPVGAGVAVTTPQLVSLDDGARALDMFKKLSIPIAGIVENMSSHICANCGSEQDI
                     FGKDTTLPLAQKYNTTILAKIPLDPAVREGGDSGKPIVYFAPDSTIAKTYRKAAHDLWE
                     FLENNRADNASIQPR"
     CDS             complement(5485..5742)
                     /locus_tag="ctg5_98"
                     /transl_table=11
                     /translation="MRHIEGKPEIHYPCLWEFRIIGEDKQDLERIVSELVAKPYTLDEK
                     NHSSKGRFVSMHLSVEVESEEERNALYQSLSTHKAIKMVL"
     CDS             complement(5760..6386)
                     /locus_tag="ctg5_99"
                     /transl_table=11
                     /translation="MSSITSTSGVNDPRAMQELFLERTNLRANQDLESQALASKLEPRQ
                     SPKELESSTNTMEKDSMLGLLSALAPAKSLDKTQGIKGLDEIDSSDKSDYKDPYDSLHR
                     IQDTFTPSKELSAAMNAKAYVKNGLADVDSFKSMAKQLQADGVLNRDDMMAVDFLSAKA
                     PHISLQDFDAMIKNDNLSREMRSLISQLVQKLHMVNYISGGLMSA"
     CDS             6540..7247
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_100"
                     /sec_met_domain="HAD (E-value: 3.2e-25, bitscore: 82.4,
                     seeds: 107, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIAFFDFDGTMAKGDSLLGFVAFVRGKKRLYWGLFSRCFILIGY
                     ALGLISNTKAKQAVMRYFFANMDYKEFLQECERFCPDLESRLKPAALARLQWHKDRGDV
                     VVMVSASFEEYLAPLCAKLGMECIGTRLATQTQNKDSRGGDSVLGSHSDDFADFKATAD
                     LKSCSALKSTQTLESTFLSGEFATPNCYGEQKAVRIKARYDLSRYEEIYAYGDSKGDTA
                     MLALATHAFYKPF"
     CDS             complement(7358..7921)
                     /locus_tag="ctg5_101"
                     /transl_table=11
                     /translation="MKKTLLAGSVLALAFSASFAAPYTIDTSHSAVNFQVTHMMISDVD
                     GAFNRFSGEIDFDEKTKTLKALKGEVLISSIDTKNDSRDKHLNAPDFFDSAKFPKATLE
                     MKSLKGKKLTADVTIRGITKQIVFDTSIKGPVTNPMSKENKLAIAIKLEGKLNRKDFGI
                     GMDTKDALVSDEVLLRIQLEAHSK"
     CDS             8042..9115
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M22"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_102"
                     /sec_met_domain="Peptidase_M22 (E-value: 5.6e-74, bitscore:
                     241.9, seeds: 111, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLSIESSCDDSSLALTEIASARLVFHHKISQDSAHSVYGGVVPE
                     IASRLHTKGLPQILAMVKEFLGDFTRLKAVAITTEPGLSVSLIEGLMMAKLLALHLHIP
                     LISINHLIGHFYSLFINQQQATFPMSVLLVSGGHTQIIEAHNAQSFHIIAQSLDDSFGE
                     SFDKVAKMLSLGYPGGPIIESYASKLAPTTALHPLPLPLKDRQGFSFSGLKNATRLLIE
                     SLHTQNDCSKLDSSLSESDRALVCASFQQASIAHIANQVEKYLKHKKHPKIRHFAIVGG
                     ASSNAALRAEIAHLCAHFGLSLHLAPLEFCADNAAMIGRAAIPEWEMGHFADVIAQEVS
                     PRSSIDYLQAASTEPCP"
     CDS             9230..10000
                     /locus_tag="ctg5_103"
                     /transl_table=11
                     /translation="MQEDKIIESYTGVTKERKKSKMPARLDFWQSATGLFLALFMLAHL
                     LFVSSILISQEAMFAVTTFFEGSFIFGDEGQPFLVSIVAAVVIVAFVAHAFLALRKFPV
                     NYRQFIALKTHKKLMQHGDTSLWVIQAATGFAMFFLAMPHLFTNLTQPEHIGPLASSFR
                     FVHQNYWLLYIFLLFAVELHGSIGLYRLCIKWGWFEKLGIQNLRRVKWALSVFCIVLGL
                     CSYAAYMKIGQGLDASKGIEHYRAVDVATKGKGE"
     CDS             10001..11971
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 425; E-value:
                     1.2e-129)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_104"
                     /sec_met_domain="FAD_binding_2 (E-value: 2e-129, bitscore:
                     425.0, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 6.5e-40,
                     bitscore: 128.9, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVVYADALIIGGGLAGLRASIAAKQKGLSTIVLSLVPVKRSHSA
                     AAQGGMQASLGNSKMSDGDNEDLHFADTVKGSDWGCDQKVARMFVTTAPKAIRELASWG
                     VAWTRIQKGDRTAVINAQKTTITEEDFRHGYIHSRDFGGTKKWRTCYTADATGHSMLYA
                     VANEAYKHGVDIQDRKEALRLIHKDGICYGAVVRDLITGELIAYVAKGTLIATGGYGRI
                     YKNTTNAVICEGIGLAIAMETGVAKLGNMEAVQFHPTPLFPSGILLTEGCRGDGGILRD
                     VDGYRFMPDYEPEKKELASRDVVSRRMIQRIREGKGVKSAYGEHLWLDISILGREHIER
                     NLRDVQEICQVFAGIDPAEKWAPVKPMQHYSMGGIRTNYQGHTALAGLFAAGEAACWDM
                     HGFNRLGGNSVSEAVVSGMIIGDYFAQHCEQAKMDIQTSVIESFVAKEQAYLESLVNNS
                     GHENVYELKNAMKDIMEEDVGIFRDGKGLEDAVARLEEIYKRSKNIGIKNKKLHNNPEL
                     EDAYRVPKMIKLALCVALGALNRTESRGAHTREDYPKRDDEKWLKRTLASWESDTQTLP
                     TLSYEDLDIMSMEIAPGFRGYGAKGMIIENPLSAKRQAEIDKITQEVQARGGDRYELQQ
                     ALMDFDLQPKYKEKNQRLGDK"
     CDS             11971..12702
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: 102.7; E-value: 3.5e-32)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_105"
                     /sec_met_domain="Fer2_3 (E-value: 6e-32, bitscore: 102.7,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 1.4e-09, bitscore: 31.1,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00055, bitscore: 13.3,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEAQGRTLTIRALKFDPHSAVSKPHFAEYKIQETDSMTIFIALNL
                     IRENQDPDLSFDFVCRAGICGSCSMMINGRPRLACRTLTKDFPETITLMPLPAFKLIKD
                     LSVNTGEWFAGMTKRVESWVHSNEETDISKLEKPIDPQEAQDVFELDRCIECGCCIASC
                     ATKLMREDFVGAAGMNRIVRFMIDSHDKRTDEDFYELVGNDDGVFGCMSLIACHDTCPK
                     NLPLQSKIAYLRRKMVAVGAK"
     CDS             12973..15090
                     /locus_tag="ctg5_106"
                     /transl_table=11
                     /translation="MQTASNAHNTHIIGGGGGGVNNLSLNASTRFSQKVALSIACISCL
                     TLTNLHARWYLFSGDVTKANCDVYPSGGNFVIDPKGSENSCQGDSARFATDGGWSKTLI
                     LDRVILESFRAGTEGVGIDASGLWGNVRLTNSTIGTANIEGKLKVEIKAVSNSNNTITA
                     INNSADRLSLSADVGSSISVTTLNQSNTPNTPSELVLQNGGGSITIENLNQSGGTTYQK
                     DGDVTTATMTDGAYYQGYGPSGGGYAPVGDGGRITTLNLQGGAFTQYAGQITTANLSGG
                     TFTHNGGTLSNVVLKAGGSGSTFVNGTDSAFANITQEGGNHTIIGKVTKFTLASGSFTN
                     NGSITTLTTSTTTKQARSGTSFYAAQAATTNHITNNGTIDKLELTKDADSVTNNAVYNT
                     GGGLASGIIKELSVTKGSATINTLNGVGQGTAGNVEPHTLSNINITKDAKLTVDTLSVG
                     LKGNQAIERVTINGDKGATGSNKEFAVNKIQVTYIDGTFDPAKSISKNLTDYVSSNIIS
                     QSYVDNNSKPTFESSPELQGIGVKFNPDGTPIFEVEASLAASMTSVVVRQSMRRKMLID
                     TYLAEQNRRSLKNKERRTKQRIEAATLADARAQYQKDLAKYKLDLAKWDKLASTKENKA
                     LIAKYEQEDKAYQAAKAQYDKDKKAYEDNRKNLELLSKAQKIKAPIEPKAPVMPNLKPS
                     DKDYKKAMANYD"
ORIGIN
        1 aaactcccgc acaaagcaat tcgcgcattg tggctttagt gccttgcaca catagcgtcc
       61 aaaaagcaca aatgcctgat gtagcgcaga taaatctgtt acaaacgctt tttctaggtc
      121 ttgctcggtt ttctctgggg ttttggcatt gcttagagct aagcggtgag agacgcggaa
      181 tacatgggta tccactgcca taacattagc ttggcaatat tctagcagca cgacattagc
      241 ggtcttttgc ccaacacctg ctagcgactt tagctcggct tgtgtagttg ggatttctcc
      301 tccaaaccgc tcgagcacct gctttgccat ttggcataaa tgcttggctt tgttgttgaa
      361 aaaagaaatg cttttaatta gctctttgac ttcttcgaca ttagcttgcg ctagtgcctg
      421 cacgctagga tagcgtgcaa ataaagctgg tgttacaaga ttcacgcgct tatcagtgca
      481 ttgagcagag agcattacac acacaagcag ctcataaata ttgcgataga ttagctctgt
      541 ctttgcctgt ggatagtggg ataaaaagcg cgctttaatc gtggcgattt gcgccttgct
      601 tcttttagtg gatttagggc gggaggtggg cttggtgagg gcttgcttta tgcgagattt
      661 actgggcatt caaatccttg ataatatctt aaagagagct acaagtaagc tctaaggtta
      721 agcttaaggc gtggctagat tctagctaga atctacatag gctctacttc tatctgcctt
      781 gcctcttcac tgcgcaaggc gatgattgtt tgatgcactt gcacagagat tgtcgctttc
      841 tttgctgaag tttgcaagct tgtgatgagc gcgccaatga caatcccaag tgatgctaga
      901 cgctcctttg ccacgatgtc ttctaaattg attgctgtaa ctttgtagct acgattatac
      961 tcacaggtat caagcttcat tttcaccctt ataatgataa tgtatattat tatagcactt
     1021 ttaccctatg cttgtgttac aatcgctagc gcaccatttg tgcttaaact taccacaagg
     1081 agtctttatg aagtttttaa gtcagtttct ctaccagcag gctttagcca catcaagcaa
     1141 gctttattac aaaatcttgc tgcgcttacg cgggatcttg ctgcggcttt gtgatccgct
     1201 cattaccact acttttagag gctatacact tactatgccc tcttctcaca caatttttct
     1261 caatcaaaag ctctatccat tttacgatat gcgcttgcaa actcttgcgc aatatctttg
     1321 tgctaaagat ggcagacttg ctatggttga tgtaggcgca aatattggcg atacggcggt
     1381 gttttcccaa gtagatggtg cttcctattt gcttatagaa ggtgagcaaa cttacgccgc
     1441 tcttatccct gccaatctcc gcgcaaacct ctctgcccca cttagtcagc atacaagcac
     1501 acaaaatcta gagtgtatga caacttggac aactagtggt tttgcggggg ggggggggac
     1561 cataaactct tccatatttg cacgacattt ttaggggata aagactcctg tggaaattat
     1621 gcaatgagct tacaagatgg cagtggcaag ctcattgcca gctctagcca atcgcctatc
     1681 tatacactag ataccatagt tcaaaaatcc agcttctctc ccaatttcat caaaatcgat
     1741 accgacggct ttgattttaa ggtgcttcgt ggtgcgatag ccacaatcaa agcttatgcg
     1801 ccagttattt actttgagtg gagctacacg catttgcttg agcaagcaga atctccttta
     1861 gcaattttcc cgcttcttag agagctaggc tatttagagc ttgtgatttt tgataacttt
     1921 ggcacactgc tttgtgtttt gccaagtgat gataggcaga atctagcctt acttatggac
     1981 tatacaaaag actctagcca aatccactac tatgatgtgc tagcgatccc aagccaaagt
     2041 gcctttaacc tgcaagaata tttgcagctc tacaccaagc aaaatgcaca ggctagggag
     2101 tggatttaaa attgcttagg gggtttgaca aatgctacaa tgattttaag caaagttgat
     2161 aaaggagtcc tatgtcgcat tttgatacca atctagccgc cttatctaag gtagatcccc
     2221 tgctttatct agcattaaag tccttcaccc ctaatcaaaa ctacgaagtc tttatggata
     2281 gcgatcctgt taattacaat atcatcgata ccaaaaatgc caaagctctc tatcttacaa
     2341 agcctattga tgagattatg gagagaaact cccagctcaa tagctactct tactatccat
     2401 ttttatatct ctatggcttg ggcaatggcg tgcttatacg cttactattt aactcacaaa
     2461 gacagcgcat agtggtgttt gagccagagc ttgagattat tttcatcgtg ctaaatttac
     2521 ttgatttctc caaggagctt gctaataagg agctagtgat tatctacaca aagcaaatcg
     2581 gctatatggg tgtggattct ctctttgata gcaacaaata ctcgcgtgta tttgttaaga
     2641 cttatgactt gcttgttgct tgcccatatt atgagagcta tcacgatgat attttgcgta
     2701 taaatggcta ttttattaaa gcgattgagc aagcagtcgt tagcgtgggc aatgatgcta
     2761 aagattctgt catagggatt tataaccaca tcgctaatct cccagatgcc ctgcgcaccc
     2821 caagcctaaa agacctcgtc ctagccctaa aggatagaga tagcgcgatt atcgtctcta
     2881 caggtcctag cttgcataag cagctaccct tgctaaagca agtcgccccc tatgcagtgc
     2941 tactttgcgt agatgcgagc ttcccaatcc taacaaagca cggcattaag ccagatattg
     3001 tcctaagctt agagcgcgtg caagagagtg ccaaattcta caccgatacg cccaagcaag
     3061 cacaaaaagg cgtggttttc gcacttacct cgatcgtcca taagcaaaca aagctagcac
     3121 ttaaaggagc aagcgtgcag tttagcttcc gcccttttgg ctacacaagt ctctttggct
     3181 ttgatgatta tgggtattta ggcataggaa tgagcgcggc aaatatggcg tatgagctag
     3241 cgatgctggc gcagtttaaa caatgcatat ttatcgggca ggatttagct tttggcgatg
     3301 atggcagctc gcattctaaa gatgctattt atggcacaca agaagcccag tataaaaaag
     3361 agggcatatt tgtcccgcgc tatggtggag agggcgagat agagacaagc aagatttgga
     3421 agctattttt acactttttt gaaaaggaca ttgctaggac atcgcctaat atggaagtca
     3481 tcaatgccac agaaggtggc gcgcgcatag tgggcacaaa ggagctgcct tttaaacaag
     3541 tagtagaatc tatcgtgcaa aaagcgcaga caaaatctcc aatcaccctc ccacaagtcc
     3601 ccactaaaca aagtgaaaaa aacatcaaaa aagcttataa aaaagtgcaa gacatcatca
     3661 aatatggtag cgtgcaaaag cgcaaaatcg agcgcgtatt cttacagctt gctaaagagc
     3721 tagagcatat agaaaagcta aatacccaaa acaagcttga gaaaatcaac ttcaccaagc
     3781 ttgatagcct aagcgataaa atcgatagta ttaaacagct ctttaatgag cggaaattta
     3841 ctagctattt tatggacgct atacaatcct acatcttcca tcaagagcta gacatcgcta
     3901 aagtgctcgt gctctatact gccaatgaag aagagatgaa agccaagcag ctacaatggc
     3961 tctactacca taaatactgg ctcttctctc ttgctggggg gattgactgc gtgatccaca
     4021 cagcgcaaaa agcccttgat gagtggagca agcaagacct agccctagca aaaagctaga
     4081 atccacacaa agtagattct aggaaagaag taggttttgg agcaaaacga ttctaaggat
     4141 tgcggtaggg ctgtggttgc tttctaaaga aacttcgctt cgcttgtttt gcgcggtttt
     4201 tagggtagga gttaccttag cggtaatgac tgccctaaaa atcgcgcaat caatccgcat
     4261 tgcctaccca agactgaatc gcttgacaaa aagtggattc tactagcgtg gctggataga
     4321 agcattatct gcgcgattat tttctaaaaa ctcccataaa tcgtgcgcag cttttctata
     4381 tgttttggcg atagtagaat ctggcgcgaa atacacaata ggcttaccac tatccccacc
     4441 ctcgcgcact gcaggatcta gggggatttt tgcaaggatt gtagtattgt atttttgcgc
     4501 caaaggaagt gtagtatctt tgccaaaaat atcttgctcg ctaccgcagt ttgcgcaaat
     4561 atgactgctc atattttcca caatgccagc aatcgggatt gagagctttt taaacatatc
     4621 cagagcgcgc gcgccatcat caaggcttac aagctgcggg gttgtaacag ccacccccgc
     4681 acctactggc acactttggg cgattgatag ctgcgcatct cctgtgcccg gtggcatatc
     4741 aagcacaagc acatcaagat cctgccacac cacatcgcta aacatctgcg taatggcgcg
     4801 cataagcata ggacctctcc atataagact ctccccctca tcaaataaca ttcccatact
     4861 cataagatct actccataag cctgcaaagg gataagtctc ttcccgcttg gatcaagctt
     4921 aggcttgatc ccgtgtagcc caaacatacg cggaatattt ggtccataaa tatctgcatc
     4981 aagcagccct actttcttgc catccatcgc tagggctatg gcgagatttg ttgccacact
     5041 tgatttgccc acaccgccct tgcctgagct taccattaca aaatgcttca cttggggtag
     5101 gagatttctc gcctgtggag cggctttaga ttctgcttga agctctgggg ttttgatagt
     5161 aatgacagct tggatattag ccttttgcaa gacattatcg atcctatcat aaagagcctt
     5221 agcgacatta ggatcgcttg aaggaatcgc cactactact tctacgccac catcaagttt
     5281 aatttctttg acaaatccat agcttacaat gtctttttca aaatttggat agagcacttg
     5341 tgataaaagc tttgtgattg ttgtttgcat ttgtatcctt atcgatgata tatgcaagta
     5401 gaatctaggt gcttagattc tagccctagc ctacttgcgc gttgttatgt aaaatatttt
     5461 ttattaaatg ttgcttaata gaatctataa gaccatttta atggctttgt gtgtgcttag
     5521 gctttggtat agtgcatttc tctcttcttc actctctacc tcaacgctta agtgcataga
     5581 gacaaatcgc cccttgcttg agtggttttt ctcatctaaa gtatagggct ttgctacaag
     5641 ctcgcttaca atgcgctcca aatcttgctt atcttcccct atgatcctaa actcccataa
     5701 gcaggggtag tgtatctctg gctttccttc tatatgtcgc atagcttgct cctaatatgc
     5761 tacgcgctca ttaagccacc gctaatgtaa ttaaccatat ggagcttttg gacaagctgg
     5821 gagatgagcg agcgcatttc tcggcttagg ttgtcgtttt taatcatcgc atcaaagtct
     5881 tggagactaa tgtgtggggc tttcgcgctt agaaaatcta ctgccatcat atcatcgcga
     5941 ttgagcacac catctgcttg cagctgcttt gccatagatt taaagctatc gacatcagca
     6001 agtccgtttt tcacataggc tttggcattc atagcagcac ttagctcttt agatggtgtg
     6061 aaagtatctt ggattctatg aagagaatca taagggtctt tatagtcgct cttatcgcta
     6121 gaatctatct catcaagccc ctttataccc tgcgttttat caagcgattt tgcaggggct
     6181 agcgcactaa gcaagcctag catagaatct ttctccatag tattggtgct agattctagc
     6241 tctttggggc tttggcgtgg ctccagcttg cttgctaatg cttggctttc taaatcttgg
     6301 tttgcgcgca aattagtgcg ctctaagaaa agctcctgca ttgctctagg gtcatttacg
     6361 ccacttgtgc tagtaatgct gctcattatc tatcctttac tatatgatat attcaagcat
     6421 tatagaagca aaagccattc cacacttgtg tgcccatctg ccaaagcact ttgcaaatac
     6481 gctggctttt agctacaatc gccacttcca caagcacaca taacgcaagg gcataatcaa
     6541 tgaatatcgc atttttcgac tttgatggca caatggcaaa gggtgatagc ctgctaggct
     6601 ttgtcgcatt tgtgcgtggc aaaaaaaggc tatattgggg gctgttttca cgatgtttta
     6661 tactcattgg atacgcgcta ggacttatta gcaacaccaa agccaagcaa gcggtaatgc
     6721 gctatttctt tgctaatatg gactataagg agtttttgca agagtgcgag cgattctgcc
     6781 cagatcttga gagccgccta aagcccgccg ccctagcacg cctacaatgg cataaagata
     6841 gaggcgatgt ggtagtaatg gtaagtgcaa gttttgaaga ataccttgcc cccttatgcg
     6901 ctaagcttgg tatggagtgt ataggcacaa gacttgcgac acagacgcaa aacaaggatt
     6961 ctaggggtgg ggattcggtt ttgggtagtc atagcgacga ttttgcggat tttaaggcaa
     7021 ccgcagacct caagtcttgc tctgccctaa aatccacaca aaccctagaa tctacttttt
     7081 taagtgggga gtttgccaca ccaaactgct acggggagca aaaggcagtg cgcattaaag
     7141 cgcgctatga tttaagccgc tatgaagaga tctacgccta tggcgacagc aaaggagata
     7201 cagcgatgct agctcttgct acgcacgcat tctataagcc attttagcta cctattttct
     7261 ctaatggcta gcgactcgca taaaaatatt taccataaaa atttttacaa agtagagtaa
     7321 gtagcactag aatctagcta gattctagtg ggaagtgtta tttgctatgg gcttcaagct
     7381 gaatgcgcag taaaacctca tcgcttacaa gcgcgtcttt tgtatccata ccgatcccaa
     7441 agtccttgcg gtttagcttg ccctcaagct taatggcgat tgcaagcttg ttttccttac
     7501 tcattgggtt tgttactggt cctttaatgc ttgtatcaaa tacaatttgc ttggtaatac
     7561 cacggatcgt aacatctgca gtaagcttct tgcctttaag agatttcatc tcaagcgtag
     7621 cctttggaaa tttcgcagag tcgaagaagt caggcgcgtt taggtgctta tccctagagt
     7681 catttttggt atcgattgat gagatgagca cttcaccttt aagggctttt agggtcttag
     7741 tcttttcatc aaagtcgatt tctccgctaa agcgattaaa cgccccatca acatcactaa
     7801 tcatcatatg ggtaacttga aaattcaccg cagaatgcga agtatcaatc gtatatggag
     7861 cagcaaagct ggctgaaaaa gctagggcta aaacagagcc agcaagtaga gtctttttca
     7921 taagaagtgt ccttacattg tggattacac caaaggtgcg ctttggattc tatcgcgcaa
     7981 atgttaatgc aaatcaattt ttgtataatg cggcggtttg gatatatctc aaggagcact
     8041 aatgctacta agcatagaaa gcagctgcga tgatagctca ctcgccctca cagaaatagc
     8101 aagtgctagg ctagtgtttc accacaaaat ttcacaagat agcgcgcata gtgtttatgg
     8161 aggcgttgtg ccagagattg cctcaaggct acacaccaag ggcttgccgc agattctcgc
     8221 tatggtgaaa gaatttttag gcgattttac acgccttaaa gcagtagcga tcaccacaga
     8281 gccggggctt tctgtgagcc ttattgaagg gctaatgatg gcaaagctac ttgccctgca
     8341 cttgcatatc ccactcattt ctatcaatca cctaatcggg catttttact cgctctttat
     8401 caatcagcag caagcaactt tccctatgag cgtcctgctt gtatctggcg gacatacgca
     8461 aatcatcgaa gcacacaatg cgcaaagctt tcacatcatc gcccagagtt tagacgatag
     8521 ctttggcgag agctttgata aggtggctaa aatgctctcc cttggctatc cgggcggacc
     8581 catcatagag tcctacgcct ccaagctcgc gcccactact gcactccacc cgctcccact
     8641 cccgctaaag gataggcagg gcttcagctt ctctgggctc aaaaacgcca ctagattgct
     8701 catagagtcc ctgcatacac aaaatgattg cagtaagcta gattctagct tgagcgagag
     8761 tgatagagca ttagtgtgtg catcatttca gcaagcatcc atagcccata tcgccaacca
     8821 agtagaaaaa tacctaaagc acaaaaagca cccaaaaatc cgccattttg ctatcgtagg
     8881 tggagcgagt agcaacgcag ccttgcgcgc agaaatagcg cacctttgcg cacattttgg
     8941 acttagccta cacctagcac cgctagagtt ttgcgccgat aatgccgcga tgatagggcg
     9001 cgcagcaatc ccagagtggg agatgggaca ctttgctgat gtgatcgctc aagaagtaag
     9061 cccgcgtagt agcatagact atctacaagc cgccagcaca gagccttgcc cctaatcgct
     9121 ctagcaagcg cattctcata attccacgat ttttagctat ttttacttat aaatagatta
     9181 taattgccca ctaccctaga atctagggag aacacactaa ggagattcaa tgcaagaaga
     9241 caagatcatt gaaagttaca caggtgtaac aaaggagaga aaaaagagca aaatgcccgc
     9301 tcggctagat ttctggcaga gtgctacggg gctttttcta gcgttattta tgcttgcgca
     9361 tttgctgttt gtatcaagca ttttgattag ccaagaagcg atgtttgcag taacgacatt
     9421 ttttgaaggc agctttattt tcggcgatga ggggcagcca tttttggtat caatcgtagc
     9481 ggcagtggtg attgtagcct tcgtggcgca cgcatttttg gcactgcgca agtttccagt
     9541 caattaccgc caatttatcg cgctaaaaac gcataaaaag cttatgcagc acggcgatac
     9601 aagcttatgg gtgatccaag ctgccacggg ctttgcgatg tttttcctag cgatgcccca
     9661 tctttttacc aaccttaccc agccagagca cataggacca cttgcttcgt cattccgctt
     9721 tgtgcatcaa aactattggc ttttatacat attcttactt tttgcagtag agctgcacgg
     9781 ctccattgga ctctatcgac tctgtatcaa atggggctgg tttgagaagc ttggcataca
     9841 aaatcttcgc cgcgttaagt gggcgttatc ggtgttttgt atcgtgcttg ggctttgctc
     9901 ctatgctgcg tatatgaaaa tcggtcaagg gcttgatgca agcaagggga tagagcatta
     9961 tcgtgcagtt gatgtcgcta caaaaggaaa aggagagtaa atgaaagtag tatatgcaga
    10021 cgcgctaatt atcggtggtg gtttggcggg gcttcgcgcc tctatcgcag caaagcaaaa
    10081 gggcttaagc acaattgtgc tttcactcgt gcctgtcaag cgcagccact ctgcagcagc
    10141 acaaggtggt atgcaagcaa gccttggtaa ttcaaaaatg agcgatggcg ataatgaaga
    10201 cctacacttc gccgacacag ttaaggggag cgattggggc tgtgatcaaa aggtagccag
    10261 aatgtttgtt accactgcgc ctaaggcgat tagagagctt gcttcttggg gtgtagcttg
    10321 gactagaatc caaaagggcg atcgcaccgc tgtcatcaac gcgcaaaaaa ctaccatcac
    10381 agaagaagac ttccgccacg gctatatcca ctctcgcgac tttggtggga caaaaaagtg
    10441 gcgcacttgc tacactgccg atgcgacagg gcactctatg ctctatgcag tagcaaatga
    10501 agcctacaag cacggcgtag atatacaaga ccgcaaagaa gccctgcgcc taatccataa
    10561 agacggcatt tgctatggcg ctgttgtgcg cgatcttatc actggcgagc ttatcgccta
    10621 tgtggctaaa ggcacgctta tcgccacagg tggctatggc aggatctaca aaaacaccac
    10681 aaatgccgtg atttgcgagg gtattgggct agcaatcgca atggagacag gagtagcaaa
    10741 gcttggcaat atggaggcag tgcagttcca ccccacccca ctcttcccta gtgggatctt
    10801 gctcacagag ggctgccgtg gcgatggcgg gatcttgcgc gatgtcgatg gctatcgctt
    10861 tatgcctgat tatgagccgg agaaaaagga gcttgcaagc cgcgatgtcg tctctcgcag
    10921 aatgattcaa aggattcgag agggcaaggg cgtgaagtct gcgtatggag agcatttgtg
    10981 gcttgatatt tcaatccttg ggcgagagca tatcgagcga aacttgcgcg atgtgcaaga
    11041 gatctgccaa gtatttgcag ggattgaccc agcggagaaa tgggcgccgg tgaagcctat
    11101 gcagcactac tctatgggcg gtatccgcac aaactatcaa ggacacaccg cacttgcagg
    11161 gctttttgcc gcgggtgaag cagcgtgctg ggatatgcac ggatttaacc gcttaggtgg
    11221 gaactctgtg agcgaggcgg ttgtcagcgg tatgattatt ggagattatt tcgcgcagca
    11281 ttgtgagcaa gcaaagatgg atatacaaac ttccgtgatt gaaagctttg tcgccaaaga
    11341 gcaagcctac ctagaatcgc ttgtcaataa tagcggacac gaaaatgtct atgagcttaa
    11401 aaacgcgatg aaagacatta tggaagaaga tgtggggatt ttccgtgatg gcaaggggct
    11461 agaagatgcc gttgctcgct tggaagaaat ctacaaacgc agcaaaaata tcggtatcaa
    11521 aaacaaaaag ctccacaaca accccgagct agaagatgcc taccgcgtgc ctaagatgat
    11581 taagctagca ctttgtgtgg ctcttggcgc gcttaatcgc acagaatcta ggggtgcgca
    11641 tacgcgtgaa gactacccca aacgcgatga tgagaagtgg cttaaacgca cgcttgcttc
    11701 ttgggagagc gatacacaaa cactgcccac actctcttat gaagacctag acattatgtc
    11761 tatggaaatt gcgcccggat tccgcggcta tggggctaag ggtatgatca ttgaaaatcc
    11821 gctctctgct aaacgccaag ccgagattga caaaatcacc caagaagtgc aagcgcgcgg
    11881 tggcgatcgc tacgagctgc agcaagctct tatggacttt gacttgcagc ccaagtataa
    11941 agagaaaaac caacgactag gagacaaata atggaagcac aaggaagaac actcaccata
    12001 cgcgccttga agtttgaccc ccatagcgcg gtgtctaagc cacatttcgc ggaatacaaa
    12061 atccaagaga cagattctat gacgattttt atcgcgctaa atcttatccg tgaaaatcaa
    12121 gacccagatc taagctttga ctttgtctgc cgcgcgggga tttgtggcag ctgctcgatg
    12181 atgatcaatg gtcgcccaag gcttgcctgc cgcacgctga ctaaggattt cccagagact
    12241 atcacactta tgccgctacc agcatttaag cttatcaaag atttgagcgt caatacaggc
    12301 gagtggtttg ctggtatgac taagcgcgtg gagagctggg tgcatagcaa tgaagagaca
    12361 gatatttcca agcttgaaaa gcccatcgat ccgcaagaag cgcaagatgt ctttgagcta
    12421 gatcgttgca ttgagtgcgg ttgctgtatc gcaagctgtg cgaccaagct tatgcgtgaa
    12481 gattttgtcg gcgcagctgg tatgaatcgc attgtgcgct ttatgatcga ctctcacgac
    12541 aagcgcacag atgaagactt ctatgagcta gtgggtaatg atgatggcgt gtttggctgt
    12601 atgagtctca tcgcctgcca cgacacctgc cctaaaaatc tcccacttca aagcaaaatc
    12661 gcttacctac gccgtaaaat ggtagccgta ggcgcgaagt aatcctctgc ctttgccttg
    12721 cgcaaaggtg ctctaactag acaaatttat tgaaacttct atcccactgc gctaggcgcg
    12781 tgggatcact ctttcctaga atccacttta ctctatattt acaagcacta catatttttt
    12841 acacgccctt tacaaacttt cgcaaacaat gtgtaaatat ttagcctaat tataaaaagc
    12901 cgtttttttt ttttttgatt ttggctacaa tgtggctctc atattttgac tatttttatc
    12961 caaggagata ctatgcaaac agcttctaac gctcataata cccatataat cggggggggg
    13021 gggggggggg taaataatct ctctctaaat gcttctacta gattctctca aaaggttgct
    13081 ttatctatcg cttgtatctc gtgcttaact ttgacaaatc tccacgctcg gtggtatcta
    13141 tttagtggtg atgtaacaaa agctaactgc gatgtctatc caagtggtgg taactttgta
    13201 attgacccca aaggtagtga aaattcttgt caaggggact cggcaaggtt tgctacagat
    13261 ggcggttgga gcaaaaccct aatactagac cgagttattt tagagagctt tagggctggc
    13321 acagaaggtg taggtataga tgcaagtggg ctgtggggta atgtccgtct tactaactcc
    13381 accataggga cggcaaatat tgaagggaag ctcaaagtcg agatcaaggc tgttagcaac
    13441 agcaacaata ctatcactgc tatcaacaac tctgctgatc gtctaagcct tagtgcagat
    13501 gtaggcagct caatctcagt tacaacgctt aatcaaagca atacccccaa tacccctagc
    13561 gaacttgtcc tgcaaaatgg tggtggcagt ataacgattg agaatctcaa ccaatccggt
    13621 ggcacaacct accaaaaaga tggcgatgta actacggcta ctatgactga tggagcgtat
    13681 tatcaaggct atggacctag tggcggtggc tacgcaccag taggtgatgg cggtagaatc
    13741 accacgctca atctccaagg cggagcattt actcaatatg ctgggcaaat cactactgcc
    13801 aatctctccg gcggcacatt cacccacaat ggcggcacac ttagcaatgt agtgcttaaa
    13861 gctggtggca gtggctctac atttgtcaat ggcacagatt ctgcctttgc taacatcacc
    13921 caagagggtg gtaaccacac tatcatcggt aaggttacta aatttactct agcgagtggc
    13981 tcctttacca acaacggctc tatcaccaca ctcaccacca gcaccaccac aaaacaagct
    14041 agaagtggca caagcttcta cgctgcccaa gctgctacta ccaaccacat caccaacaac
    14101 ggcaccattg ataaactaga gcttactaaa gacgctgata gtgtaaccaa taatgctgtg
    14161 tataacacag gcggtggctt agcaagtggt atcatcaaag agctaagcgt aacaaaaggc
    14221 agtgccacca tcaacaccct aaatggtgta ggacaaggga cagcaggtaa tgtagagcct
    14281 catacactct ctaatatcaa catcactaaa gacgctaaac tcaccgttga taccctaagt
    14341 gtaggactca aaggcaacca agctatagag agagtaacaa tcaatggaga taaaggcgct
    14401 acaggtagca acaaagaatt tgccgtcaat aaaatccaag taacctatat cgatggcacc
    14461 tttgaccctg caaaaagcat tagcaagaat cttacagact atgtatctag caatatcatt
    14521 agccaaagct atgtcgataa caattctaag cccacctttg aatcaagccc agagctccaa
    14581 ggcatagggg tgaagtttaa tcccgatggc acccctatct ttgaggtaga agcctccttg
    14641 gctgcaagta tgacaagcgt agtcgtgcgc caatctatgc gacgaaaaat gcttattgac
    14701 acctatctcg cagaacaaaa cagaagaagc ttgaaaaaca aagagcgcag aaccaagcag
    14761 cgcatagaag cagccaccct agcagatgca agagcccagt atcaaaaaga cctagccaaa
    14821 tacaagctag acttagccaa atgggataaa cttgctagca ccaaagagaa caaagcccta
    14881 atcgctaaat acgagcaaga ggacaaagcc taccaagcag ccaaagctca atacgacaaa
    14941 gacaaaaaag cctatgaaga caaccgcaaa aacctagagc tactctctaa agcgcaaaag
    15001 atcaaagctc ccatagagcc taaagctcct gtaatgccaa atctcaagcc aagtgataaa
    15061 gactacaaaa aagctatggc taactatgac a
//
