LOCUS       NZ_KK211296.1          12601 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_KK211296.1 Ruminiclostridium cellobioparum DSM 1351 = ATCC 15832
            T344DRAFT_scaffold00019.19, whole genome shotgun sequence.
ACCESSION   NZ_KK211296
VERSION     NZ_KK211296.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-13 23:46:04
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12601
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12601
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[114:2601]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      115..2601
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..12601
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12601
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             115..1314
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_1"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 1e-44, bitscore:
                     146.3, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 5.2e-38,
                     bitscore: 123.0, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKALIIGAGGVASVVIHKCCQNPDVFEEICIASRTVEKCDAIKA
                     KLDGGKTKIQTARVDADNTEMVIELINKFKPDIVINVALPYQDLTIMDACLATGVHYLD
                     TANYEPPEIPKFEYKWQWAYRERFEKAGITALLGSGFDPGVTSVFCAYAQKHYFDEIHY
                     IDIVDANAGDHGYHFATNFNPEINIREITAPGSYWENGEWVETEPLELKKVYDLPEIGP
                     KDIYLLHHEEIESLALNIKGVKRIRFWMTFSEKYLTHLRVLENVGMTSIEPIEFEGKKI
                     IPLQFLKAVLPDPASLGPRTKGKTNIGCIIQGIKDGKPRTYYVYNVCVHEECYAEVGSQ
                     AISYTTGVPAMIGAMMILKGIWKKPGVYNVEEFDPDPFMDALNKYGLPWKEDFSPRLLD
                     "
     CDS             1450..2601
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_2"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 4.9e-16,
                     bitscore: 51.5, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDINIDIDFGKLPTPCYIVDERLLIKNLEILDSVQKRTGCKILLA
                     QKGFSMHAVYPLIGKYLKGVTSSSLFEARLGYEKMGKEVHVYAPAYIEEEFDELLKYTD
                     HIVFNSFAQWERFRSRVKSYPGKRIECGIRINPEYSEQEHAIYDPCSRHSRLGVTLKNF
                     RPEQLDGIDGLHFHTMCEQNSDTLERTAGAVEEKFGEFIKHMKWLNFGGGHHITRQDYD
                     IETLVRTISRFQDKYGVQVYLEPGEAVALNTGYLVAEVLDIVENEMNIAILDTSAACHM
                     PDVLEMPYRPNIIAAGKPGENKYTYRLGGPTCLAGDIIGDYSFREPLNPGDRLVFCDMA
                     HYTMVKNNTFNGVNLPAIVLYSQKDGVEIVRKFQYGDFETRLS"
     CDS             2799..4166
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SBP_bac_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1044:Bacterial extracellular solute-binding protein
                     (Score: 126.3; E-value: 8.1e-39)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_3"
                     /sec_met_domain="SBP_bac_1 (E-value: 1.3e-38, bitscore:
                     126.3, seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKAISKALAAGMAIVMTLSIAACGSSTPAATSTSTAAASSAAPS
                     STAAESSAPAGEPVKLTFWHIQTTEPFPGLMEEWMKNFSTENPNYTVEVTAVQNDAFKQ
                     KLLISMSSNQTPDIFPHWSGGPMNQYADEGKIADLTTYMNENNYKDRFMTAAINQATYK
                     DKIWAVPVENTSVAMFFYNKELFAKYNLQVPKTIKELEALCDTLKKNGIIPFSLANKTQ
                     WTGSMYYMYLADRFGGPEPFNAAAQRTGSFENEAFTQAGNKIQEWVKKDYFNKGFNGLD
                     EDSGQSRTLLYSGKAAMTLMGSWFLSTVKGENPEFFDKNVGSFPFPAADDGKGDPNSVV
                     GTVGDNFYSVSATSKDVAGAFKAITYLIDDKAVATRVENGRVPPVKGVKVTDPRLQDVL
                     NAVEKAPYVQLWYDQYLPAEVAQVHKDTSQAIFGLAKTPEQVNKEMEAAAKKYFGK"
     CDS             4305..5207
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_4"
                     /sec_met_domain="BPD_transp_1 (E-value: 3e-16, bitscore:
                     52.3, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQSTKSLLSYRKRNTAIAATVFLIPVFLFILIFIVYPIINSFWLS
                     LHNWNGISSNKVFYGLENWKTLATDTVFYKSFLNNIIIVILSIAIQLPIAMALAFLLDT
                     GGKKLNFLKMVYFLPMLMSSVAVGFLFKYTYDPQFGLISAVSTLFGGEGMVDLLGNPKV
                     AIYAVITVICWQYIPFYMVYFLAAFSSLPEELYEASIIDGATYGQYFWRVALPCMKGTV
                     KSAAVLSLVGSLKYFDLIYVMTQGGPNGATELMATYMYKNAFQTMQMSYGSTIASGMFL
                     VITLISLLTLRALNGREEA"
     CDS             5211..6044
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 79.8; E-value: 7.2e-25)"
                     /gene_kind="transport"
                     /locus_tag="ctg19_5"
                     /sec_met_domain="BPD_transp_1 (E-value: 1.2e-24, bitscore:
                     79.8, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRKKNSAGKIIVALLALLWLVIAGAPFYFMVISAFKEQFEILTT
                     GVFSIPKGFYMDNFAGVIKSQFYKYLLNSTFVVIVSLVLILVTALCAAYPFSRFKFKLN
                     KPLFGLVVAAMAVPIHVTLIPIFQLTQKIHLYDTIYALIGPYTAFNLPISVFILTSFMA
                     EIPKELEESAEIDGCGKYRTFFHIIAPLSKAGLATLAIYNAVNMWNEFSFALVLTQSAK
                     SRTLPLSIWDFQGQYNSNVPMIMAVLTFCALPMIVAFAIGQDKLIKGMMAGAVKG"
     CDS             6164..7462
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SBP_bac_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1044:Bacterial extracellular solute-binding protein
                     (Score: 91.6; E-value: 3e-28)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_6"
                     /sec_met_domain="SBP_bac_1 (E-value: 4.8e-28, bitscore:
                     91.6, seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKRILPILIALIIVLPLSGCFYDGHMGMTTQRAQKKQLTLYSIQG
                     DSAVNEVITDSVNRFESSNSGFEVVHELIPNDLYKNRLSVCVATNQMPDVFPTWSGSIL
                     KEYVSIGGVVNLSSYMSKEDYSSRFNKKALDMVTFGDGIWGVPVENMSVAMIFYNKSIY
                     KTLNLSEPANFTQLKKNIEVLKEHGYIPFALANRTAWTGSMFYMYFVDRLGGPEVFDNA
                     ANRKNNGSFDNEVFVRAGQMVQQLVDMRAFPQGFNWMDEDSGDARNLLYNETAAMTLAG
                     SWFLSNVKFENPGFYEKIGVFPFPAIEGGKGNPNNSIGTMGDNFYSVAGSCNYIDQAFE
                     LVQYLIDDTAVQKRIHAGKIPPVNDVSIEDPLTNEVFDFIKKSPNVQFWYDQYLPPKLS
                     EAHLALTRQIFGGEDPKRAAKSMEDITRQYYSQ"
     CDS             7474..9252
                     /locus_tag="ctg19_7"
                     /transl_table=11
                     /translation="MKNWLLQLAKKKMRNIPFRSKLTYYLVITICLTVLIVVGFSYTVT
                     SRSIKQQAKDMTMLQLQQNTSNLEDYLQNIESTPDSIVTDRSFQEYLSRHDEDSMDFSA
                     TVDDVYRSMSNIMGSKRDILYMFLYKAIDNNILYLGPTKAGQDSDYSNVAAYMSKKDIS
                     GSPIRVSFRQDPILTKKYTLTIYQPIFDIYRIKRPIGMLGISVTEDVVARFYSHSKRDL
                     PLETFIMNGQGTIVSHTDKSKISSSAGLDEILDKHDGSAEIGGKLVVYKYIEDWDWYVV
                     GTLPISYLLRDNNVMLLAILAIVIFTIILASFISLIFSRHLLRPFNDLIYRMSMVSKGD
                     LTTRINLSDHGYDFEQVSKGFNLMVEQINVLMQRIYDEQRQLKEIEFKALQAQINPHFL
                     YNTLESIHWQALMNGHHEISTMVKALAGFYRISLSRGEAIIPLMNESQHVENYLTIQEM
                     RYKDKMESYIDIPEEFLEVMIPKMTLQPLVENSIYHGLRVKQSKGFIKITAVREGEDLI
                     VKVIDNGIGMVPDQIKSLNRTLEDNDSGVGYGVRNVHRRIKLFYGNPYGLFYESNEYGG
                     VTVNVRLHINREENNI"
     CDS             9315..10868
                     /locus_tag="ctg19_8"
                     /transl_table=11
                     /translation="LYKVLIVDDEVMIRNGLYNMIPWKKLEIGDVRTASCAQEALELAR
                     ETKPDIVLTDICMPEMDGLEMTRLMLEFLPDLKVLVLTGYDDFKYAQKSCYLGVKEFIL
                     KPVDEVSLANSIKLQVENIKNELQSSLKCNILNRKRVLENQRAFEKSLMQLTEKSNETE
                     EMDIDDLALEENCRYQVGLISPVLSGDSVWVQHKNLLLISIKTILIDMIDSNNSGWTFQ
                     NRDGDIVVIFYIKNNNDSAEDQISRLQEIVNVEYDVDLETGIGPIVANISKIKTSYKKA
                     KENVKANKAEFDLQEDSQGIEGSRQKDKLSYYRNQMLESIPDTEAVKKYLKLYIDEVKN
                     SGMKKVNAEQKFYELASAFYWEYLKTTGYQADGRLETLITTLQSNDLENCCVFIEMFIA
                     KLMYTNKKQMHEIVEAATKYIKDNLTEDLTVFTLAEQFHVARNYFSRLFKKEMGEGCNE
                     YITRLRIEKAKQLLGASRLKTYEIAEKVGYHDTNYFSLAFKKNTGLSPKEFREKLNNPE
                     "
ORIGIN
        1 gcaatacttt gaaagcgcac atggccaatt aacctccttt attcgccaca ttgcgataaa
       61 ggatataggt tttcattaca ttttgtggcc gctatgcggc tcatggaggt taatatggga
      121 aaagctttaa ttattggtgc gggcggcgtt gcaagtgttg taatccataa atgctgccag
      181 aaccccgatg tattcgaaga aatatgcata gccagcagaa cagttgaaaa gtgcgatgcc
      241 ataaaagcca aactggatgg aggaaaaacc aaaatccaga ctgcccgggt tgacgcagac
      301 aacaccgaaa tggttattga acttataaat aaatttaagc ccgacatagt tataaacgta
      361 gcgcttccgt atcaggacct cactattatg gatgcgtgtc ttgccacagg agtgcactat
      421 ctggacactg caaactatga gccgcctgaa ataccaaagt ttgaatataa atggcagtgg
      481 gcctacaggg aaagatttga aaaggcaggt atcacagctc tgctgggcag cggctttgac
      541 cccggcgtaa caagtgtttt ttgcgcttac gcccagaaac actattttga cgaaatacat
      601 tatattgata tagttgacgc caatgcaggc gatcacggct accactttgc tacaaacttc
      661 aaccctgaaa tcaatatacg tgaaataaca gcgcccggca gctactggga aaacggagaa
      721 tgggtggaga cagaacctct ggagctcaaa aaagtgtatg atctgcccga gataggacca
      781 aaggacatat acctgctgca ccatgaggaa atagaatccc ttgccttgaa tataaagggc
      841 gtaaagagaa tcaggttctg gatgactttt tcggaaaaat acctcactca cctgagagtg
      901 cttgaaaatg tgggtatgac ttcaatagag ccaatagaat tcgagggtaa gaaaataatt
      961 ccgcttcagt tcttaaaggc cgtattgccc gatcctgctt cacttggacc cagaacaaag
     1021 ggcaagacca acattggctg catcatacag ggtataaagg acggaaaacc cagaacatat
     1081 tatgtctaca atgtatgcgt ccatgaggaa tgctacgccg aggtgggctc ccaggccata
     1141 tcctatacaa caggggttcc tgccatgata ggtgccatga tgatattgaa gggaatctgg
     1201 aagaaaccgg gagtatacaa tgtggaagag tttgatcccg atccgtttat ggacgccctg
     1261 aacaaatacg ggcttccctg gaaagaggat ttttctccca ggcttcttga ttgattcctg
     1321 attaattcct attgcttctg attgatacga aactgaaaat acgccgctgt tcacatgctt
     1381 gatgcaggta tgcaggtgga cagcggcgta taatatatat cctcatatgg aaaggccgtg
     1441 gtaactgtta tggatattaa tattgatatt gattttggga aattgcccac accctgttat
     1501 atagtcgatg aaagacttct tataaaaaat cttgaaatac tggattcagt ccaaaaaagg
     1561 acgggctgca aaattctgct ggcccagaag ggcttttcca tgcatgcggt ttatcccctg
     1621 attggaaagt accttaaagg tgttacctcc agctcgcttt ttgaagccag gctggggtat
     1681 gaaaaaatgg ggaaggaagt ccatgtatat gctcccgcat atatcgaaga ggagtttgat
     1741 gaactgctga aatacacaga tcacatagta ttcaactcct ttgcccagtg ggagaggttt
     1801 aggtccaggg tcaagagtta ccccggcaaa aggatagagt gcgggatacg cataaatcct
     1861 gaatattccg agcaggagca tgcgatatat gatccctgct ccaggcattc aaggctggga
     1921 gtcacactga aaaatttcag gcccgagcag ctggacggca tagacgggct gcatttccat
     1981 accatgtgcg agcagaattc agacaccctg gaacgtaccg ccggagcagt ggaagagaag
     2041 ttcggagagt ttataaaaca catgaagtgg ctgaattttg ggggaggaca ccatattaca
     2101 agacaggact atgatatcga gacacttgtc agaaccataa gccgcttcca ggataaatac
     2161 ggcgtacagg tatatcttga acccggtgaa gccgtggctt taaacacagg ctacctggtg
     2221 gcagaggtac tggatatagt agagaatgaa atgaatatag caatactcga tacctcggcg
     2281 gcctgccata tgcccgatgt gctggagatg ccctacagac ccaacataat agctgccgga
     2341 aagcccgggg aaaataagta tacttacagg ttgggaggcc ccacctgtct ggcgggagac
     2401 ataatagggg actattcttt cagggaacca ctgaacccgg gcgacaggct ggttttctgt
     2461 gacatggccc attacaccat ggtaaagaac aataccttca acggtgtcaa tctcccggcc
     2521 atagtgcttt acagccaaaa ggacggggtg gaaatagtaa ggaaattcca gtacggtgat
     2581 tttgagacaa gattatcgta aatattgttt agaattgaat attgattttt gtataaacct
     2641 aacaaaaaag ttaggttttt tgcttctata tgacacaaaa ttatatgaag aggtaagttt
     2701 tataaattaa attgatcctc ctttgatgct attataaata cataaggcgt gactgaacat
     2761 tgagctcatg ccagtatatt aaaggaggtc atgaaaatat gaaaaaagct attagtaagg
     2821 cccttgctgc aggtatggcc atcgttatga cgttgtccat agcagcttgc ggttcatcga
     2881 caccggcagc tacttcaacc tcaaccgcgg cagccagcag tgctgctccg tcatcaaccg
     2941 cagcagaatc atctgcaccg gcaggggagc ctgtaaaact cacattttgg catatccaga
     3001 caacagaacc tttcccggga cttatggaag agtggatgaa gaatttctca acagaaaatc
     3061 caaactatac tgttgaggtt acagcggttc aaaatgacgc tttcaaacaa aagcttctga
     3121 tttcaatgag ttcaaatcaa actccggaca tattccctca ctggtcgggc ggaccgatga
     3181 accaatatgc cgatgaagga aagattgctg acttaactac ctacatgaat gaaaataact
     3241 ataaagaccg cttcatgacg gcagctataa accaggctac atataaagat aaaatttggg
     3301 cagtacctgt tgaaaacaca tcggtggcaa tgttcttcta taacaaggag ctgtttgcaa
     3361 agtataatct gcaggttcca aagacaatta aagaacttga agctctttgt gacactttaa
     3421 agaagaatgg tatcatacct ttctctctgg ccaacaagac tcagtggaca ggttccatgt
     3481 attacatgta tctggctgac cgtttcggcg gacccgaacc tttcaatgct gcggcacagc
     3541 gcacaggttc ctttgaaaat gaagcattta cccaggccgg aaacaagatc caggaatggg
     3601 tcaagaagga ttacttcaac aaaggcttca acggtcttga tgaagattcc ggacagtcac
     3661 gtactctcct ttattcagga aaagctgcca tgacacttat gggctcgtgg ttcctttcaa
     3721 ccgttaaagg tgaaaacccg gaattttttg ataagaatgt aggttctttc ccattcccgg
     3781 ctgctgacga cggaaaaggt gatcccaatt cagttgttgg tactgtagga gataacttct
     3841 attcagtttc cgcaacctcc aaagatgttg caggagcctt caaagctata acttacctta
     3901 tagacgacaa ggctgtggct acacgtgttg aaaacggcag agttcctcct gtaaagggtg
     3961 taaaggttac cgacccgcgc ctccaggatg tattaaatgc agttgaaaag gctccttatg
     4021 ttcagctgtg gtatgatcag tatctcccgg ctgaagttgc ccaggttcac aaggatactt
     4081 cacaagccat atttggtctt gcaaagactc cggaacaggt aaacaaggaa atggaagcag
     4141 cggctaaaaa atactttggc aaataataat cagtaactta aaagtatcta taattgattg
     4201 ggtatcactc atctgatacc catcaattat attactgtca aaatatttat tcctaaaaat
     4261 aaccggtctg aaataagctg cttactcaga ggggaggaga aacaatgcaa agtaccaaat
     4321 cactcttaag ctacagaaaa cgcaatacgg caattgcagc aacagtattc cttattccgg
     4381 tattcctctt tatcttgatt tttatagtat atcctattat caactctttt tggctaagtc
     4441 ttcacaactg gaacggaatc agttccaata aggtttttta cggcttggaa aactggaaaa
     4501 cacttgcgac cgacaccgtc ttttacaagt cttttcttaa taatataata atagtaatcc
     4561 tgtcaatagc catacagctg cccatagcca tggcactggc ctttctgctg gatacggggg
     4621 gaaagaaact gaatttcctc aagatggtct atttcctgcc catgctcatg tcctcagtgg
     4681 cagtcggctt cctctttaaa tatacctacg acccccagtt cgggctcata agtgcagtgt
     4741 ccacattatt cggaggagaa ggcatggtag atctgctggg aaatccaaag gtcgccattt
     4801 atgccgttat cacagtcata tgctggcagt acattccatt ttacatggta tatttcctgg
     4861 cggctttcag ttccctgccc gaggaactct acgaagcttc aataatcgac ggtgccacat
     4921 acggacagta cttctggaga gttgcactgc cctgtatgaa gggtactgta aagagcgctg
     4981 cggttctctc acttgtgggc tcgttaaaat attttgatct tatatacgtt atgacccagg
     5041 gaggacctaa cggtgcgaca gagctcatgg ccacgtatat gtacaaaaac gccttccaga
     5101 caatgcaaat gagctatggc tcaaccattg cctcaggtat gttccttgta attacattga
     5161 tttcattgct gaccctcagg gctttgaacg gaagggagga ggcgtaaagg atgaccagga
     5221 aaaaaaattc agccggaaaa ataattgtag cgttattggc cctgttatgg ttggttatag
     5281 caggagctcc attttacttc atggtaatct cagcctttaa agaacagttt gaaattctca
     5341 ccacaggtgt attttcaata cccaagggtt tttatatgga caacttcgca ggtgttatta
     5401 aaagccagtt ttacaaatat ttgctgaaca gcacctttgt ggtgattgtt tcactggtac
     5461 ttattctggt tacggcactg tgcgcggcat atccattttc aagatttaaa tttaagctta
     5521 acaagcccct gttcggactt gtggtagccg caatggccgt gcccatacac gtgactctta
     5581 tacctatctt tcagctgacc cagaaaatac acctgtatga caccatttat gcgcttatag
     5641 ggccgtatac cgccttcaat ctgcccatat cggtattcat tctgaccagt tttatggcag
     5701 aaataccgaa ggaactggaa gaatctgctg aaatagacgg ctgcggcaaa tacaggacct
     5761 tcttccatat catcgcgcct ttgtcaaagg cgggactggc cacactggcc atttacaacg
     5821 ccgtcaacat gtggaatgaa ttcagcttcg cacttgtact gacccagtcg gcaaagagca
     5881 ggacattgcc tttgtcaata tgggatttcc agggacaata taattccaat gtccccatga
     5941 taatggccgt attgaccttt tgcgcacttc ccatgatagt tgcctttgcc atcggtcagg
     6001 ataagctgat caaaggcatg atggcaggag ccgtgaaagg ataggggctg tatacatgta
     6061 aaactttttt gctgttaccc ggggataaat atggtgtata ataaaaatgc atatgttatc
     6121 cctggcggtt tataacacac gtaagcatgc agaggaggtt agcgtgaaaa gaatacttcc
     6181 aatccttatt gcacttataa tagttcttcc gctgtcgggc tgtttttacg acggacacat
     6241 gggtatgacc actcagagag cgcagaaaaa acagctgacc ctgtacagta ttcaggggga
     6301 ttctgccgta aacgaggtta ttaccgattc agtcaaccgg tttgagagca gcaatagtgg
     6361 ttttgaggta gtacatgaac taattcccaa tgatctgtat aagaacagac tttctgtgtg
     6421 tgtggctaca aatcagatgc cggacgtgtt tccaacctgg tcgggaagca tattgaagga
     6481 atatgtgagc atcggaggag ttgtaaacct gagcagttat atgagcaagg aggattacag
     6541 ctccagattc aacaaaaaag cacttgatat ggttaccttc ggagacggaa tatggggtgt
     6601 tccggtagaa aatatgtcgg ttgcaatgat tttctataat aagagtatct ataagacgct
     6661 taacctgtcg gaacccgcca atttcaccca gctcaagaag aatatcgagg tacttaaaga
     6721 acatggttat ataccttttg ccctggccaa cagaacggcc tggacgggtt ccatgttcta
     6781 tatgtatttt gtggaccgcc tgggaggacc cgaggtgttt gacaatgctg ctaacaggaa
     6841 aaataacggt tcctttgaca atgaagtatt tgtaagagcc ggtcaaatgg tacagcagct
     6901 ggttgacatg agagcttttc cccaggggtt caactggatg gatgaggatt ccggagatgc
     6961 gcgcaatctt ctctataatg aaacggctgc catgaccttg gccggaagct ggtttttgag
     7021 caatgtaaaa tttgaaaatc ccggatttta tgaaaagata ggagtttttc ctttccccgc
     7081 aattgaaggg gggaagggaa atccaaacaa ttccataggt accatggggg ataattttta
     7141 ctctgtggca ggttcctgca attacattga tcaggccttt gagcttgtgc agtatctcat
     7201 tgacgatact gcggttcaaa agcgcattca cgcaggcaaa attcctccgg ttaacgatgt
     7261 cagcatagaa gatccgctga caaatgaagt atttgatttt ataaagaaat ctccaaatgt
     7321 tcaattctgg tatgaccaat acctccctcc caagctttcg gaggcccatt tagcccttac
     7381 aaggcagata ttcgggggtg aggaccctaa acgtgctgca aagagtatgg aagatataac
     7441 acgacagtac tatagtcaat aaagggtgag cctatgaaga actggttatt acaattagct
     7501 aaaaagaaaa tgaggaatat tcctttcaga tcaaaactta cttattatct tgtaataaca
     7561 atatgcttga ccgtattgat agtggtgggc ttttcatata ctgtgaccag ccgttccata
     7621 aaacagcagg caaaagatat gacaatgctt caactccagc aaaatacctc aaaccttgag
     7681 gactaccttc aaaacattga aagtactccc gacagcatag tcaccgacag aagctttcag
     7741 gaatatcttt cgagacatga tgaagacagc atggactttt cggccactgt ggacgatgtt
     7801 taccggtcca tgtccaatat aatgggctcc aagagagata tattatatat gtttctttat
     7861 aaggccattg acaataatat tctttatctg ggacccacaa aagcaggaca ggactccgac
     7921 tactccaatg tggcagccta catgtcaaaa aaggacatct caggaagtcc cataagggtc
     7981 agtttcaggc aggatcccat tttaacgaag aaatataccc ttacaatata ccagcccata
     8041 tttgatatat acaggataaa gagacccatc ggcatgctgg gcatatcggt aacggaggat
     8101 gtggtggcca ggttttattc ccacagcaaa agggatctcc cccttgaaac ctttattatg
     8161 aacggtcagg gtacaattgt ttcccacacc gacaagagta agataagttc aagtgccggg
     8221 ctggatgaaa tcctggataa gcacgacggt tcggccgaga tcggaggaaa gctggtcgta
     8281 tataaataca tagaagactg ggactggtat gtggtgggta ctcttcccat cagctacctc
     8341 cttagagata ataatgtaat gcttctggca atactggcca tagttatttt caccataata
     8401 ctggcatcat ttatctcatt gattttcagc cggcatttgc tgcggccctt taatgatctg
     8461 atatacagga tgtcaatggt atcaaagggg gatctgacca cacgcataaa cctatcggac
     8521 cacggctatg atttcgaaca ggtatcaaaa ggtttcaacc tcatggtgga acagataaat
     8581 gtcctcatgc agagaatata tgatgaacaa aggcagttaa aggagatcga gtttaaagca
     8641 ctccaggcac agataaatcc tcactttctt tataacacgc tggagtcaat acattggcag
     8701 gcccttatga acgggcatca tgaaatttcg accatggtaa aagccctggc aggcttctac
     8761 cgcataagcc tgagccgtgg agaggccatt attcccctga tgaatgagtc ccagcatgtt
     8821 gaaaactatc tgaccataca ggaaatgcgg tataaggaca agatggaaag ttatatagat
     8881 attcccgagg aatttctgga ggtaatgata cctaaaatga cccttcagcc cctggtggaa
     8941 aactcgatat atcacggcct gagagtcaag cagtcaaagg gctttataaa aataaccgct
     9001 gtccgtgaag gggaggattt gatcgtaaaa gtcatagaca atggtatagg tatggtcccc
     9061 gaccagataa aaagcctgaa ccgtacactg gaggataacg attcgggtgt gggctacggg
     9121 gtcaggaatg tccacaggag gataaagctt ttttacggaa acccctatgg cttgttctat
     9181 gagagcaacg agtacggcgg tgtcaccgta aatgtcagat tgcatattaa ccgggaggaa
     9241 aacaatatat aatttgcaga gggtttctta tgacttggga aaatagactt aaaggaaaag
     9301 gttggtgaag tatattgtac aaagtgctga tagttgacga tgaggtaatg atacggaacg
     9361 gcctgtataa tatgattcca tggaaaaagc ttgagatagg tgacgtccgg actgcttcct
     9421 gtgcccagga ggctcttgaa cttgcccgtg aaacaaagcc cgatattgta ctgaccgata
     9481 tatgcatgcc tgaaatggac ggcctggaaa tgaccaggct tatgcttgaa ttccttcccg
     9541 atctgaaggt gcttgtactt accggctatg atgattttaa atatgctcag aagagctgct
     9601 atctcggtgt taaagaattc atactgaagc cggtggatga agtcagcctg gcaaacagca
     9661 tcaagctcca ggtggaaaac ataaaaaacg agctgcagtc ctctttgaaa tgcaatatcc
     9721 tcaacaggaa gagggtactg gaaaatcaga gagcctttga aaaatcactc atgcagctga
     9781 ccgaaaagtc caatgagacc gaagaaatgg atattgatga tctggctctg gaggagaact
     9841 gccggtatca ggtggggctc atatcacccg tgctgtcagg tgacagtgtg tgggtgcagc
     9901 ataaaaatct attgttgatt tcaattaaaa ccattcttat agatatgatt gattccaata
     9961 attcgggctg gacctttcaa aacagggacg gagatattgt tgtgatcttt tacataaaaa
    10021 ataataatga cagtgccgag gaccagattt ccaggcttca ggaaattgta aatgtggaat
    10081 atgacgtgga tctggagacc ggtatcggtc ccatagtggc caatatttcc aaaataaaga
    10141 cctcatacaa aaaagcaaaa gagaatgtga aagcaaacaa agcagaattt gatttgcagg
    10201 aggatagcca gggtattgaa ggctccaggc agaaggataa gctgtcgtac tacaggaatc
    10261 agatgctgga gagcataccg gataccgaag cggtaaaaaa gtaccttaag ctgtatattg
    10321 acgaggtaaa aaactcagga atgaaaaagg tgaatgccga gcagaaattc tatgagctgg
    10381 cttcggcctt ttactgggaa tatctgaaaa ccacaggcta ccaggccgac ggccgtctgg
    10441 agactctgat aacgacactg cagagcaacg accttgaaaa ctgctgtgtt ttcatagaaa
    10501 tgtttattgc caaactgatg tataccaaca aaaaacaaat gcatgagata gttgaagccg
    10561 ctaccaaata tattaaggac aatctgaccg aggaccttac ggtatttacc ctggcagagc
    10621 agttccatgt tgcccggaat tatttttcca ggctgttcaa aaaggaaatg ggagagggct
    10681 gcaacgaata cattaccagg ctccgcattg agaaggcaaa gcagcttttg ggggcgtcaa
    10741 ggctgaaaac ctacgagatt gccgaaaagg taggttatca cgacacaaat tatttttctc
    10801 tggcctttaa gaaaaatacc ggattatcgc cgaaggagtt cagagaaaag cttaacaatc
    10861 ccgaataaaa taattggtaa actgttttcc agtcccatga caaatttgca ggatttgcat
    10921 taaaactgcg attattaagg aaactaatac tataaccatg atcaggaggt attgtagcta
    10981 tggcagtaaa taccagaatt tttcactgtg acgaatactt tcgtctccca agaaaagaaa
    11041 aaaaggaatt tgacagtatt attctaaaag aactggaaga gaatcctgtc aggcatctgg
    11101 agactgaatg gggaagattt gaaaatctgc ctcccatgtc cgaagaggag attgacaggc
    11161 tggcagagga tgttttgagt gagatgtccc tggagcagaa ggttcaccag atgtcctgcg
    11221 ataattatgc aagatatgca ctcatcaatc ctccgagata taatttcata ccctattatg
    11281 ccggagaaaa cctggaactt ggcataccgg cagtcaaatt tacagacgga cctacgggaa
    11341 tagtgctggg ctatcatgcc accgccttcc ctgtctccat agcccgcggc tcctcctggg
    11401 ataccgaact ggaggaacgt gtgggagatg tcattggaat agagggccgc tcgggcggcg
    11461 caaacttctt tgccggggtt tgtataaacc tgctgcgcca ccctgcctgg ggacgtgccc
    11521 aggaaaccta cggagaagat acggttctgc ttggaaaaat gggtgcggct ttgacaaagg
    11581 gcgttcaaaa gcacatgatg gcctgcataa aacattacgc cgcaaacagt atggaaaacg
    11641 cccgcttcaa ggttgacgtg caaatggacg aaaggaccct gcgggaaatc tatctccccc
    11701 actttaaagc ctgtgtggat gcgggcgcag ctgcaatcat gagtgcctac aaccgtgtaa
    11761 gagggcagtg gtgcgggcac aacagctacc ttctcaatca gatactcaac ggtgactggg
    11821 gtttcaaagg tctggtgatg tccgacttca tatggggtgt gagagacacg gtagaagcgg
    11881 ctaacggagg aatgtgcata gaaatgtatg ccacacagta tttcggagaa aggcttgtgg
    11941 aagcggtcag ggaggtcaag gtggacgaaa gcaggataga tgaggcagtc aagcgcattc
    12001 tgaggcaaaa gatcagattt tcctttgtgg gtgacagggc attatattct gaagataaaa
    12061 tgggctcaag ggaacatgcg gccctggctc tggaggtatc tgaaaagtcc acggttcttc
    12121 ttaaaaatga cggcatatta cccctccaca gggacagggt caaaaaaatt acggtggtcg
    12181 gaaagctggc cgtccggccc aataccggtg acctgaaggg cagcagtgcc gtattccctc
    12241 cctatgtggt cactcccctt caggggcttg tcaatgaagc cggcggcagc attgagatat
    12301 gctatgttga cggaaggacc ccccaccagg ctcaggaact gtccagaaat gccgatgcag
    12361 tggtggtggt tgcaggcctt acttcacttg acgagggtga atttattaca aatggaggag
    12421 atgtgggcgg agacagaaaa aatctgggcc tgcacccaga ggatgaagac ctcattgaaa
    12481 cggtttcccg ggtcaacccc aatgtcatag tggtaatgca gggcggcagc acaataattg
    12541 tagagccctg gaagaagttt gccaaagcaa ttctcatgca gtggtatccg ggtatggagg
    12601 g
//
