LOCUS       c00050_NZ_JAFR..       15320 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_JAFRGN010000052.1 MAG: Butyrivibrio sp. isolate RGIG2449
            Goat_Ileum.Co__c693728, whole genome shotgun sequence.
ACCESSION   c00050_NZ_JAFR..
VERSION     c00050_NZ_JAFR..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 01:24:04
            Original ID  :: NZ_JAFRGN010000052.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15320
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15320
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1735:5320]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1736..5320
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..15320
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15320
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             3..119
                     /locus_tag="ctg50_1"
                     /transl_table=11
                     /translation="EKEEKEDIAEASEKADNTEENADQKPENKKKKKSRKNN"
     CDS             265..1713
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg50_2"
                     /sec_met_domain="OKR_DC_1_C (E-value: 1.3e-14, bitscore:
                     46.1, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 3.9e-123,
                     bitscore: 402.4, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LDLNRQKKAPVYEALERFRKQRVVPFDVPGHKRGRGNPELVSFLG
                     DRCVGIDVNSMKPLDNLCHPVSVIKEAEELMADAFGAAHAFMMVNGTTSAVQAMVLSHV
                     KKGEKIIMPRNVHKSAINALILCGAIPVYIDPKVDTNLGIPLGMELADVKKAIEENPEA
                     KAILINNPSYYGICSNLKAIVDLAHENGMKALVDEAHGTHLYFGPNLPLNAMAAGADMA
                     AISMHKSGGSLTQSSILLCGPDANIGYISRIVNLTQTTSASYLLLGSLDISRRNLALNG
                     ASSFEKVTKMAQYAREEINDIGGYYAYGNELKNGGSIYDFDETKLVVNTRKIGLTGIEV
                     YDLLRDEYDIQMEFGDLSNVMAYISIGDRLQDIERLAGALADIRRLYAKPEQSFFSAEY
                     VTPIVKATPQEAFYAEKESLPIDQTVGRISAESVMCYPPGIPILSPGEVITEEILDYIK
                     TAMAKGCSMQGPESEDISELFVLK"
     CDS             1736..2608
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg50_3"
                     /sec_met_domain="Spermine_synth (E-value: 2e-50, bitscore:
                     162.2, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 1.8e-12,
                     bitscore: 38.5, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEMDYWFSDMHTGNVKISIRLAKQLFSGTSEFQRIDVFDSPEFG
                     KFLASDGNIIFSEKDEFTYDEMIVHVPMAVHPKVQRVLVLGGGDGGVARELCHYDEIKV
                     IDVVEPDNMFVDVCKQYFPDNAVGLEDDRVHIYYQDGLKYLRKCEDMYDLIINDATEPL
                     GHEAGLFTKEFYGSCYKALHDDGIMVYQHGSPFYDEDEESCRAMHRKAYRVFPVNRVYQ
                     AHIPTCPAGYWLFGFASKKYHPLKDFNPDRWDERGIKTWYYTTHLHKGAFMLPKYVEDL
                     LQEEEDMSR"
     CDS             2710..3972
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg50_4"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 3.9e-41, bitscore:
                     133.2, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 4.1e-31,
                     bitscore: 99.4, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRLLVIGCGGVAQVAIQKCAQNSAVFTEMCLASRTVSKCDALKD
                     KLEKQGTPVKITTATVNADDVNDVIKLIKEYQPDAVLNVALPYQDLTIMDACLACKVDY
                     IDTANYEPEDTDEPVWRAAYEKRCKEKGFTAYFDYSYQWAYMDKFKEAGITGLLGTGFD
                     PGVTSVFVAYAKKHYFDEIHTVDILDCNGGDHGYAFATNFNPEINLREVSANGSYWEDG
                     HWIETKPMEIKRVYDFPQVGQKDMYLLHHEEIEALGRNFPEIKRIRFFMTFGQSYLDHM
                     RCLEDVGMLSTSPIMFEGREIVPIQFLKALLPDPASLGPRTVGKTNIGCIFRGIKDGKE
                     KTLFIYNVCDHQECYKELGSQAISYTTGVPAMIGTALVLSGKWKKPGVFTTDEFDPDPY
                     MEMLNEYGLPWVVDENPVLVD"
     CDS             4112..5320
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg50_5"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 1.9e-12,
                     bitscore: 38.8, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLTEVRTPAYVIDEKKLRENLEILDRVQKESGAKILLAQKAYSV
                     YQTYPLIAKYLTGATASGLYEARLAHEELKVREGIENHVYEPAFEDDEMAELCQICDHI
                     VFNSLNQLEHHRKTWEQPVREGKISVGLRINPEFSTQEEHEIYDPCSEGSRLGIKLADM
                     PAELPEGVEGIHFHTLCEQDFEPLRQTFHHVEENFGRFFPLKNEGQEPSGDMAVNGAGR
                     KIKWINLGGGHHITREDYNVDGLITFIKEIKSKYDMEVYLEPGEAIALDAGYLVTTVMD
                     IVHTQRMPVLVLDTSAACHMPDVLEMPYRPPLRDSEQPGELEFNYRLSSRTCLAGDVIG
                     DYSFVHEINIGDKLIFEDMAIYSMVKNNTFNGMPLPDIDIMHENGEVEVIKKFGYQDFK
                     MRL"
     CDS             5333..6610
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAD_porph"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg50_6"
                     /sec_met_domain="PAD_porph (E-value: 4.8e-112, bitscore:
                     365.7, seeds: 436, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LSGITNSVPIKDGFYMPAEYSRHDGTIMIYPVRPGSWRKDRAGAL
                     YSFANVFIEILKRENLYLIADKAHWKEARDFMDEIITDYVQGTGRLVAPMTKEEEDRII
                     AEGESLFANEDTLYTVSDVLENRCLIPPIDSDDAWARDVGPTFVVRDNAGSKAEIRGIN
                     WSFNAWGGEVDGLYASWDKDDKVASSFCDLIELPFYDAQPFVLEGGSIHCDGEGTAMVT
                     ESCLLSEGRNPAMSREEIEEKLREYLNVEKVLWLPRGIYNDETNEHVDNVCAFVAPGEV
                     VLAWTDDENDPQYELSRADLEYLEKETDAKGRSIVVHKLPIPDHSVLVSEADLANYEFE
                     EGEDFREVGERLAASYVNFYFINGAALVPQFGGENEESDERALDILSELCPDREIIGIP
                     ARDILLGGGNIHCITQQIPENNLGEN"
     CDS             6613..7512
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CN_hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg50_7"
                     /sec_met_domain="CN_hydrolase (E-value: 4.6e-48, bitscore:
                     155.2, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGNMVKVACVQFACGEVAASDAEQVKRNIEKADKLTREAAANGAK
                     IILLSELFERKYFCQERRYDYYELALPLSENPAVAHFKKLCAELKVVMPICVYEKDGNV
                     FYNSVVMIDADGSDLGVYRKTHIPDDHYYQEKFYFTPGNTGFKVFDTAYGRVGVGICWD
                     QWFPETARCLTLGGADIILYPTAIGSEPILDVDSSGHWMRTMQGHSAANIIPVAAANRI
                     GREDVEPSEENGGQKSSLTFYGNSFLTDVTGDCITRASKDKEEIIYAEYDFAENGKMRA
                     SWGLFRDRRPECYRQITD"
     CDS             7521..8336
                     /locus_tag="ctg50_8"
                     /transl_table=11
                     /translation="MTIEAYLNPDFTIIKKLIFLCLTLALSGVCIGIIFLFSKAYGKKY
                     DERCREDYTKEDFEVRLQKFFEMIISGTCVMSFSCAYVIINHVYELVETGKAVNLTPFE
                     TFLTTTWADGKDFVLLFLICFSCVLNSILDTFIIPLKILKSEEKATMRMLGMFFAIITL
                     MYLNTIGDESQYGPVMMYYFGLMIGRFVYFDASFKDFLANMKKVIENSPILLMYVIYTW
                     ILVFTGFKLEYFLERNYYIVGIFHSQLFMIFVVLIVFWIDRIINKTAAK"
     CDS             complement(8362..9249)
                     /locus_tag="ctg50_9"
                     /transl_table=11
                     /translation="MGYKDYMVRATAGNAQIRAFAATTRDLADYGRKAHGLSPIATAAL
                     GRLMTGTVMMGQMMDNDSDMITVKMDGDGPLKGVLATADNKGNVKGYVSNPYVIMEPNA
                     AGHLNVGGGIGEGTLTVIRDMGLKEPYVGQVPLYTGEVAEDLTYYFTKSEQTPSSVGLG
                     VLVERENLSVIAAGGFIVQLMPFADEQTITHLEFNLGKFSSVTDILKAGKTPEDMLRIV
                     LDGFDIEFTDTVDLNFYCNCDKDRVERALMLVGKKDIQDMIDDGKEIEIKCHFCNKAYT
                     FSVDELKAIKEKAK"
ORIGIN
        1 aagaaaagga agaaaaagaa gatatagcag aggcttctga aaaggctgat aatactgaag
       61 aaaatgcgga tcagaaacca gagaataaga aaaagaaaaa gtctagaaaa aacaactaaa
      121 agttactcat attttgcttt aatattaaga agttttatag tatgattaca ttactgtgta
      181 attagataat aagagggggt agcatgtcag tatggcatgc cactccttta cttgtgtgta
      241 aggatttttt tggagggtag ttagttggat cttaatagac aaaaaaaggc tccggtatat
      301 gaagctttgg agaggtttag gaagcagcgc gttgttccat ttgacgtgcc tggtcataaa
      361 agaggaagag gtaacccaga gctcgtaagc tttttgggtg acagatgtgt tggcatagat
      421 gttaactcta tgaagcctct tgataatctc tgccatcctg tttctgttat caaggaagca
      481 gaagagctta tggctgatgc ttttggcgca gctcatgctt ttatgatggt taatggtact
      541 acaagtgctg ttcaggctat ggttttatcc catgtcaaga agggtgagaa gatcattatg
      601 cccagaaacg tgcataagag tgctatcaat gctcttattc tgtgtggtgc tattcctgta
      661 tatattgatc ccaaggtaga tactaatctt ggtattcctc ttggaatgga gcttgcggat
      721 gttaagaagg ctattgagga gaacccagaa gctaaggcta ttctcattaa taacccttca
      781 tattacggta tctgttctaa tctgaaggct attgttgatc ttgctcacga gaatggtatg
      841 aaggcccttg ttgatgaggc tcatggaact catctttact ttggacctaa ccttccactt
      901 aatgccatgg cagcaggcgc agatatggca gctatcagta tgcacaaatc tggcggaagt
      961 cttactcaga gctcaatcct tctgtgtgga ccagatgcta atattggata tatcagtaga
     1021 atcgttaacc tgactcagac cacaagtgcc agctaccttc ttcttggaag tcttgatatt
     1081 tccaggagaa accttgctct taacggagca tccagctttg agaaggttac caagatggct
     1141 cagtacgcaa gagaagagat caatgacatt ggtggctatt atgcttatgg taatgagctc
     1201 aaaaatggcg gaagcatcta cgatttcgat gagaccaagc ttgtagttaa caccagaaag
     1261 attggtctta caggtatcga ggtttacgac ctccttagag atgaatatga cattcagatg
     1321 gagtttggtg atctgtctaa tgttatggca tatatatcaa ttggtgatag acttcaggat
     1381 attgagagac ttgcaggagc tcttgctgat atcagaagac tttatgctaa gcctgagcag
     1441 agctttttct ctgcagagta tgtgactcct attgttaagg caactccaca ggaagccttc
     1501 tatgcagaaa aagagtcact tcctatcgat cagactgtag gcaggatcag tgcagagtca
     1561 gtaatgtgct atccacctgg aattccaatt ctgtctccag gagaagttat tacagaagag
     1621 attcttgatt atatcaagac tgcaatggct aagggctgtt caatgcaggg ccctgagagt
     1681 gaagatattt cagagttatt tgtgttaaaa taatagatgt gtaggaggaa atagcatggc
     1741 tgagatggat tattggttca gtgatatgca cactggaaat gttaagataa gtatcaggct
     1801 ggctaaacag ctcttttccg gaacaagtga gttccagaga atagacgtgt ttgattcccc
     1861 tgagtttggc aagttccttg cttcagatgg taatatcatc ttttctgaga aggacgagtt
     1921 cacatatgac gagatgatcg ttcacgtgcc tatggctgtt catcccaagg ttcagagagt
     1981 actggttctt ggtggtggtg acggaggcgt agcaagagag ctgtgtcact atgatgagat
     2041 caaggttatt gatgtagtag agcctgacaa catgtttgtg gatgtatgta agcagtactt
     2101 ccctgataat gccgttggtc ttgaggatga cagagttcac atctattatc aggacggact
     2161 taagtatctt cgtaaatgtg aggatatgta cgaccttatt atcaatgatg ctacagagcc
     2221 tcttggtcat gaggcaggtc tttttacaaa agagttctac ggaagctgct acaaggcact
     2281 tcacgatgat ggaatcatgg tttatcagca cggaagccca ttctatgatg aggatgagga
     2341 gagctgcaga gccatgcaca ggaaggctta cagagtattt cctgttaata gagtttatca
     2401 ggcgcatatt cctacatgtc ctgctggata ctggctgttt ggatttgcca gcaagaagta
     2461 tcatccgctc aaggatttca accctgatag atgggatgag agaggaatca agacttggta
     2521 ttacactacg caccttcaca agggagcgtt catgttgcct aaatacgtag aggatcttct
     2581 tcaggaagag gaagatatgt ctagataaca tggtcataag tgattgccaa tgcaagcttg
     2641 cttgcgaatt ggcatattac ttcatgacct gatccgatgt tatctatagt gaagaaaagg
     2701 agaaataaaa tgggaagatt attggttatt ggctgcggcg gcgtagcaca ggtagcaatt
     2761 cagaaatgtg cacagaatag cgctgtattt acagagatgt gccttgcgag cagaactgtt
     2821 agcaagtgtg atgcactcaa ggacaagctt gagaaacagg gaacacctgt taagatcaca
     2881 acagctactg taaatgctga tgatgttaac gatgttatca agcttatcaa ggagtatcag
     2941 cctgacgctg ttcttaacgt agcacttcct tatcaggatc ttacaatcat ggacgcatgt
     3001 cttgcgtgca aggttgacta tattgataca gctaactatg agccagagga tacagatgag
     3061 cctgtatggc gtgcagctta tgagaagcgc tgcaaggaaa agggctttac agcttacttt
     3121 gattacagct atcagtgggc atatatggac aagttcaagg aggctggtat cacaggtctt
     3181 cttggaacag gttttgaccc tggtgtaaca agtgtattcg tagcttacgc taagaagcac
     3241 tattttgatg agattcatac agttgatatt cttgactgca atggtggtga ccatggttat
     3301 gcctttgcaa ccaacttcaa tcctgagatc aaccttcgtg aagtaagtgc taacggcagt
     3361 tactgggagg atggccactg gatcgagact aagcctatgg aaattaagag agtatatgat
     3421 ttccctcagg ttggtcagaa ggatatgtac cttcttcatc acgaggagat tgaggcactt
     3481 ggccgcaact tccctgagat caagagaatt cgtttcttca tgacatttgg tcagagctat
     3541 cttgatcaca tgagatgtct tgaggatgtt ggtatgcttt caacaagccc tatcatgttc
     3601 gaaggtagag agatcgttcc tattcagttc ctgaaggctc ttttaccaga tcctgcaagt
     3661 cttggaccta gaactgttgg taagacaaac atcggatgta tcttccgcgg aatcaaggat
     3721 ggcaaagaga agacactctt catttacaat gtttgtgatc accaggaatg ctacaaggag
     3781 ctcggcagcc aggctatcag ctacacaaca ggtgttccag ctatgatcgg tacagctctt
     3841 gtactgtcag gcaagtggaa gaagccaggt gtattcacaa ctgatgagtt tgatccagat
     3901 ccatacatgg agatgcttaa cgagtatggt cttccatggg ttgttgatga gaatccagtt
     3961 cttgtggact aataagtaag tagatatata ggtggaagtt tgtgaaaatg aacttccacc
     4021 tttttaatgc atgtttaagg gcgtgtttgc atcttaacaa ttcgattgat atgatagata
     4081 tgtacattca cttttttatg gaggaatgcc tatgaagctt acagaggtga gaacacccgc
     4141 gtatgttata gatgaaaaaa agctaagaga aaatcttgag attctagata gagtacagaa
     4201 ggagtcagga gctaagatac ttcttgctca gaaagcatat tctgtatatc agacttaccc
     4261 acttatagct aaatatctta ctggtgctac ggcgtcaggc ttatatgagg cgagacttgc
     4321 tcacgaagag cttaaggttc gggaaggcat agagaatcat gtatatgagc ctgcctttga
     4381 agatgatgag atggcggagt tgtgccagat atgcgatcac atcgtattta attccctcaa
     4441 ccagcttgag catcacagga aaacctggga acagcctgta agagaaggta agatttctgt
     4501 tgggcttaga atcaatcctg agttcagtac tcaggaagag catgagatat acgatccttg
     4561 ttctgaagga tcaagacttg gaattaagct tgctgatatg ccagctgagc ttcctgaggg
     4621 cgttgaggga atacattttc atactctctg cgagcaggat ttcgagccgc ttcgtcagac
     4681 cttccatcat gtagaggaga actttggaag attctttcct cttaagaatg aaggacaaga
     4741 gccttcaggc gatatggctg taaatggtgc tggtcgcaag atcaaatgga taaaccttgg
     4801 cggcggacac catattacaa gagaagacta caatgtggat ggccttatca cctttattaa
     4861 agagataaag agcaagtatg atatggaagt gtaccttgag cctggagaag ccattgcgct
     4921 tgatgcgggc tatcttgtta caacagtaat ggatatcgta catacccaga gaatgccggt
     4981 tttggtactt gatacatcag ctgcctgcca catgccggat gtactggaga tgccatacag
     5041 gccaccactt cgtgactcag agcagccagg agagctggag ttcaactata gattgtcttc
     5101 ccgaacttgc cttgctggag atgtcattgg tgattatagc tttgtccatg agataaatat
     5161 tggagataag cttatctttg aagatatggc tatctatagt atggtcaaga acaatacctt
     5221 taatggcatg ccacttcctg atattgatat tatgcatgag aacggggaag tagaagtaat
     5281 caaaaagttt ggttatcagg actttaagat gagactgtga aggagaatag aattgtcagg
     5341 gattacaaat tcagttccta taaaagatgg tttttacatg cctgctgagt attcaaggca
     5401 tgatggcaca ataatgatct atcctgtaag accaggaagc tggaggaagg acagagctgg
     5461 tgccttatat tcttttgcta atgtatttat agaaatcctc aagagagaaa atctctatct
     5521 tatcgcagat aaggcccact ggaaggaagc aagggacttc atggatgaga taattacaga
     5581 ttatgtacag ggaacaggac gtttagtagc gcctatgacc aaagaggaag aggacaggat
     5641 cattgcagag ggtgagagtc tttttgcaaa tgaagatact ctttatactg tatctgatgt
     5701 tctcgagaac agatgtctta ttccacctat tgattcagat gatgcctggg ccagggatgt
     5761 tggacctaca tttgttgtaa gggataatgc cggttctaag gctgaaattc gtggaatcaa
     5821 ctggtctttt aatgcctggg gcggagaagt cgatggactc tatgcttcct gggataagga
     5881 tgataaggtt gcaagtagtt tttgcgatct gatagaactt ccattttacg atgctcagcc
     5941 ttttgtgttg gaaggtggtt ccatccactg cgacggcgaa ggaacagcca tggtcacaga
     6001 gagttgcctt cttagcgaag gtagaaaccc agccatgagc agagaagaga tagaagaaaa
     6061 actcagagaa tatctgaatg tagagaaggt actgtggctt ccacgaggta tatataacga
     6121 tgagaccaac gagcacgttg ataatgtgtg cgcgtttgtg gctccgggtg aagtagttct
     6181 tgcctggaca gacgatgaga atgatccaca gtatgaactt tcaagagctg atcttgagta
     6241 tcttgaaaaa gagacagatg ccaagggcag gagcattgtt gtacataagc tccccatccc
     6301 tgatcattcg gttcttgttt cagaggctga ccttgccaac tatgagtttg aagagggcga
     6361 agatttcaga gaagtaggcg agagacttgc tgcaagttac gtgaatttct actttataaa
     6421 tggagcagcc ttggttcctc agtttggcgg cgagaacgaa gaaagtgatg agagagctct
     6481 ggatatctta agtgagctgt gtcctgacag agaaatcatc ggcataccag caagagatat
     6541 acttctggga ggcggtaata ttcattgtat tacccagcag ataccagaga ataatttggg
     6601 agaaaactaa gaatgggaaa catggttaaa gttgcctgtg tgcagtttgc ctgcggcgaa
     6661 gtggctgcat cagatgctga gcaggttaaa agaaatatag aaaaggcaga taagcttaca
     6721 agagaggcag cggctaatgg tgctaagata attcttttgt ctgagctgtt tgagcgtaag
     6781 tacttctgcc aggagcgaag atatgactac tatgagcttg cacttcctct gtctgagaat
     6841 ccggctgtag cacactttaa aaagctgtgt gctgagctta aggtggttat gcctatctgt
     6901 gtatatgaga aggatggcaa tgtattttac aactcagttg tgatgataga tgctgatgga
     6961 agtgaccttg gagtgtaccg caagactcat attccagatg accattatta tcaggagaaa
     7021 ttctatttta ctccaggtaa tacaggcttt aaggtgtttg atacagctta tggccgcgtg
     7081 ggcgttggca tctgctggga tcagtggttc ccggagactg caaggtgcct tacacttgga
     7141 ggtgccgaca ttattcttta tcctacagca attggctcgg agcctattct tgatgtggat
     7201 agttcaggac actggatgcg cacaatgcag ggacattcag cagctaatat tattccagtg
     7261 gctgcagcca acagaattgg aagagaggat gttgagccat ccgaggaaaa cggcggacag
     7321 aaatccagcc ttactttcta tggtaatagc ttccttactg atgttactgg cgattgtatt
     7381 accagagcca gcaaggataa ggaagaaata atctacgcag aatatgattt tgcagagaat
     7441 ggaaaaatga gagcatcctg gggacttttc agagatcgca gaccagagtg ttacagacag
     7501 attactgatt gaggaatgtc atgacaatag aagcttattt gaatccagac tttacgatta
     7561 tcaagaaact gattttttta tgcctgacct tggcgcttag cggcgtttgt ataggaatta
     7621 tctttctttt ttctaaggct tatggcaaga aatatgacga aagatgcagg gaggattata
     7681 caaaagaaga ctttgaagtg agacttcaga agttctttga gatgataata tcaggaacct
     7741 gcgtaatgtc tttttcctgt gcttatgtca tcatcaacca tgtgtatgag cttgtggaga
     7801 cgggaaaggc cgttaacctt acgccgtttg agacgtttct gacaactacc tgggcagatg
     7861 gtaaggattt tgttctgctg tttttgatat gcttttcatg tgttcttaat tccatactgg
     7921 atacctttat tattccgctc aagatactaa agagcgaaga gaaggctacc atgagaatgc
     7981 ttggcatgtt ctttgccatc ataactctga tgtaccttaa tactataggt gatgagagtc
     8041 agtatgggcc tgttatgatg tattactttg gactaatgat aggtagattc gtgtactttg
     8101 atgcttcctt caaggatttc ctggcaaata tgaagaaggt tatagaaaat tcgccgattc
     8161 ttctgatgta cgtcatatac acctggatat tggtgtttac aggatttaag ctggaatatt
     8221 ttcttgagag aaattactac attgttggta tattccactc tcagctattt atgatatttg
     8281 ttgtgttaat agttttctgg atagacagga taataaataa aaccgcggcc aagtgaccgc
     8341 ggtttttcta tgtacattga attatttggc tttttctttg attgccttaa gctcatctac
     8401 tgagaaggtg taagctttat tgcagaagtg acactttatc tcgatttctt tgccatcatc
     8461 tatcatgtcc tgaatatctt ttttaccaac aagcataaga gcacgctcta cgcggtcctt
     8521 gtcgcagttg cagtagaagt taaggtctac tgtatctgta aattcgatat caaatccatc
     8581 aagaacaatc ctaagcatat cctctggtgt cttgcctgcc ttgagaatgt ctgtgacgga
     8641 tgagaactta ccgagattga actcgagatg tgtgattgtc tgttcatcag caaaaggcat
     8701 gagctgaaca atgaagccac cagctgcgat tactgaaagg ttttctcttt ctacgagaac
     8761 tccgagacca acggaggaag gtgtctgctc agatttggtg aagtagtagg taaggtcttc
     8821 agcaacttct cctgtgtaga gaggaacctg gccgacatat ggctctttta atcccatgtc
     8881 tctgataact gtaagagttc cctcgccgat tccgccgcct acattaagat ggccggcagc
     8941 gttaggctcc atgataacgt atggattgct gacatagccc ttaacgttgc ctttattatc
     9001 agctgtagcg agaacgccct taagtgggcc atcaccgtcc atcttgactg tgatcatatc
     9061 gctgtcatta tccatcatct gacccatcat aactgttcct gtcatgagcc ttccaagagc
     9121 tgctgtagcg attggagata ggccgtgagc ctttctgcca taatcagcaa gatccctggt
     9181 ggtagctgcg aatgctctta tctgtgcgtt gcctgctgtg gcacgtacca tgtaatcttt
     9241 gtatcccatg tatatatatt tctccttgtt tctgaaaatc gattgtatca agttttttaa
     9301 ctcaacaata ttatacgaaa aaaacatata tgtaaacact tggacaaaaa tacaatattt
     9361 actggtcaaa aaagactatg catatatata aaatgtgcgt aataagcgct tgttttcaga
     9421 taatttgaaa tggtcaaaaa tgcaaaacat tatgctgaaa atgcaatgcc aatttccgac
     9481 aaaatgccta aaatatgtta ttagataaat tattatttgt aacattttta tgtctgcgat
     9541 cttgaggggg attgctaagt aaggaaatgt taacaaaaag gggaaaggaa aaaaggaggt
     9601 tgttgggatg tataagggta gtaaccgacg ctccaaggcg ctaggcagaa gtcttgcact
     9661 tggtatgagc gccattatgg ctgcgtcaac tattgctgct ggtacaggaa gcatcacagc
     9721 atttgcggaa gagggggtaa gttctcttga ttcttcagat gtggtcgttt ttgacgagga
     9781 agcttctgag gctggtagcg attctagtag tgaagctact tcattagaat ctgacacaga
     9841 aactgatgag gccaaagagg atacttctga agatgaagta gttctttttg atgaggcaga
     9901 ggaaggagat tctcttgatt ctgagcttga tgagcttgaa cttgaagaaa ctcaggctga
     9961 ggctttggat gaagaaacca aggttacagc taatcttctt gctactacag caaatgtaaa
    10021 tgcttctgag gatggagtta ttgcagatca gggagatgat ggctttgata atttccatga
    10081 agatctgact gttgcagata tcagattcgg tacaaatggt aacgtttcat ctgcaagtgt
    10141 ttatagtaag gataatggat acggttttag cgatgttgat tatagccagg cagctgccgg
    10201 ctgggttagc aacgtttatt atccaagagt tcctgctgtt tctgcaggag ctggcaatgt
    10261 agttgatgct gaagactatg ttgctattgc cagcaagatt tggacagaaa ctgaatctac
    10321 aggctatggc gtttatacat atgagagtac atctactttt gatgtagatc tttataatgc
    10381 tgattacaag gttgaggtta catttgttaa ccctactgat aacggctata ctgcagctct
    10441 tgaggctgag gacattacca aggttactgg tatctcagtt cccgctggcg gaagtcaatc
    10501 agctagcttt gaggctaacc ttgtagatgg caatcttaat cttaagttcc ttggcacaag
    10561 tagtgccaca tctatgagtg atgcgcagac tacaaaggtt tatgtttcca gagtcaagat
    10621 cacaagactt gctactgagg aaagaggtga taagcctaca atctttgttg cttctgactc
    10681 aactgttcag acttatgatt cctattatta tccacagact ggatggggcc aggtcctttc
    10741 ttcatacttt ggtgatttcg tagaggaaag agagtgtgac gactgcggat acagccagtc
    10801 acaggtttac gagacagcaa atgtaattgt agagaaccgt tcaattggtg gacgttcatc
    10861 caagtccttt atcgacgagg gtaagtttga tgatatcctt gaggacatca agccaggtga
    10921 ctacctcctt gtacagtggg gacacaatga cgctacttac tcaagaccaa acagatatgt
    10981 ttctgctgat gattttgaga agtggatgat ggtttatgta aatggtgcta tagaaagagg
    11041 tgcaacacct gtacttgtta caccagttgc ccgctatagc tacacaacta acccagatgg
    11101 aagccttaat tcttttgcaa gtaacttcga agcatacaga caggtaatgc tgagattatc
    11161 tgcacagtac gacattcctt atgttgatct tacacagcgt tctatcgatg tatgtaacag
    11221 ctttggaatc gaaggctcca agatgctttt ccttaagctt gcagccggtg aggtatctac
    11281 aggcgcatat gcaggtggcg ttgatgattc tacacacctt cagtactatg gagcacttaa
    11341 gtttgctcag tgtgtagcag aaggtattgt tgattatgct agtggtaagg ttgagggtgc
    11401 ttcagacaag cttgatgatc tggctggtct tgtagttatc aatgcagctt cagaagctcc
    11461 ggctaagcct cagggtctta agacaacttc aattggtgcc acaagcattt cacttgagtg
    11521 ggaagctgct gagggcgcag agctttacta tatttacaga gcagcacttt cagagggaca
    11581 gacaattgat gatgtagatt tttcaaaggc tgataagtat tctgtttcag gtaagacaac
    11641 ttatgttgat ccaagctgtg gaggtggcgt tacatatgta tatgccgtag caggctttaa
    11701 cagctatggt gtaggagaag tatctgacaa gcttgcagtt tctactaaga cagcaggact
    11761 tcgctttgac tttaactaca acaattctcc tacaatggaa ggttggactg gtgttaacca
    11821 gaatgagatg tacactgctg aaaaaggcta tggatggatc acagctccta acaatggccg
    11881 ttacagaggt ggaaatggca aggctgattc atcagctatg gcagatgact ttaaccttgg
    11941 tgccggagaa tttgcagttg atcttccaaa cggtaaatat gaaattacag tatatgctgc
    12001 agatctttta aatggaacaa gtacaattaa gcctgcatat tctgctgagg gaatttcaat
    12061 cggatcaatt gcctgcaagc agtctcttgg aagctgcaca ggaacagtaa gtgttacaga
    12121 tggtcagctc aatctgacag tagaaggtgc taatcagtac atcaacggtg ttactattac
    12181 atctctttta ccagctcctg gaaaccttgc tattacagag ctttcattcg gtaagaccac
    12241 agcaacattc cttctgtcat tcactaaggt agaggatgct gtatcctaca gagtttacca
    12301 gaagggtgag tctgataaga ccttcaatct ggttaagagc tacacagcac aggaacttat
    12361 cgacaacgag cttgactgcc gcgctatgac agcagctctt ggtgaaactt attcatacta
    12421 tatgacatgc gttgttgcag acggttctga gtcagcagca agtaatatcg ttactcagtc
    12481 aatgcttgat agcagcgttg cagtacctgc agcagttcgt ggccttaagt gcacaagccc
    12541 tgaggaaggc caggaagagc ttcagacaac aattactctt gcatgggatg agagcccagc
    12601 tgatgagaat gttatcaagt acatcatcta tcgttctgct aaggcagaga gcgataaggg
    12661 cttcaaggag tttgttaagg ttggagaatc ctttacaaat tcatttacag atgaagatcc
    12721 tgagatagct acaaatattc actattacta caaagttgct gctatgaatg caggtggaat
    12781 cggtgagcag tctgagactg ttgtaacccc tatcgctggt tcacttgtag caggcggact
    12841 tgagtcttat gctacacgtg ctcttgtagt aatgaacctt gccggagatg ctggagcaga
    12901 gatcaaggtt tctgcaacag atagagatgg caatcctatt accagaggaa attacctctc
    12961 atggagaagc ttccctggtg acttcaatgg caaagaactt acaacaacat tcaatgtata
    13021 cagaaatggt acatgtattg cacatgatat cagtgcaacc aacatgatcg atgagggtgg
    13081 ccttccatcc aatgtttata ctgtagttgg ctccaatgat tcttctcttg gccttacagc
    13141 aaaagaaaca actgtatggg ctaaccagta cattgagctt agccttaata agcctgcaga
    13201 tgagacaatg ccagatggtt caacctgttc atatactgct aatgatatgt ccgttggaga
    13261 tcttgatggc gatggagagc ttgaactcat cgttaagtgg tatccaagta atgccaaaga
    13321 taactcaggt tctggctaca caggaaagac cttccttgat ggatatgagg tggattttag
    13381 cacaggtgct gtaagccagc tctggagaat tgatcttggt gttaacatca gatctggtgc
    13441 tcactataca cagttccagg tttgggacta cgatgcagac ggtattgcag agatcgcaat
    13501 gaagactgca gatggtacaa caacttacaa gaatgagaat ggaagtcttg ttgagactgg
    13561 atttgtaggc gcttgcaaca gcgatgcact tcctacagat gttatcagtt ccaagaacga
    13621 ttacagaaat acatctggtt atgttctcga tgggccagag tacttctcaa tgttcaaggg
    13681 caacactggt gaacttattg atacaactaa ttacgttcct gctagaggat cagtatcagc
    13741 atggggcgat ggctatggta acagagtaga cagattcctt tctgcaactg cttaccttaa
    13801 cggaacaact cctttcgcag tatttgctag aggatattac acaagaacag ctcttacagc
    13861 ttattatctc acaaagacaa cagatgatga gggcaaagaa gtagagcaga tcggtgttta
    13921 ctggaagttt gatacagaca acattgaaaa tggttcagct tatacagctc agggtaacca
    13981 cggcctttct gtcaacgatg ttgatggcga tggcaaagat gagatcgttt acggttcact
    14041 tactatcgac aacgatggaa cagctcttta ctgcacaggc cttggtcacg gcgatgcaat
    14101 gcatgtaagt gactggattc cttctaatcc tggtcttgag gttatggatg ttcacgagca
    14161 tgacaatgct gcataccatg tagaaatcca tgatgctgag acaggtgaga tgatcactgg
    14221 ttactacaca ggtaaggata ccggacgtgg aatggcatca gatatcgatc ctacagcaga
    14281 gggagcagag tactggtcaa ttgctaaccc taactacaag ggcaatgatg agccagcatg
    14341 gaattccaga aatgctgatg tatttagctc actttcagga cttgttggag cttcaaatgg
    14401 atcagtagat tcaatgatcg cactttcaga tggtgctaca ccagctgtta acttctcaat
    14461 gttctgggat ggagaccttc ttgcagatat gcaggatcac accttcaacc aggctgcata
    14521 tgcaccactt acaacaacta ttgagaagtg ggattatgag aaccagaagt caataacact
    14581 ctttgagtca tcacaggttc ttacaagtaa cggaacaaag ggcaaccttg gtcttgttgc
    14641 agatattctt ggtgattaca gagaagaaat catcgcaaga tgcgctgctg atgacagcag
    14701 aattagaatt tactcaacaa caattcagac tgattatgta gttccttgct cgcttacaga
    14761 ccttgcttac agagaaggtg ttgcttggca gaacgttggc tacaaccagc ctgcacatac
    14821 aagctatctc atctctgaag gcattatcac ttccaaggtt tcagagggaa gcgttgatgc
    14881 aagtagcgta acaatcaact tcacacaggc aaatgacggt gtatatggtc atgatattca
    14941 gggctatgtt gttaaaagag ctgacgtaac agttgacgaa aacggcaacc aggtaattgg
    15001 cgattacgag acagtaggag agcttgatgc taagggtgtt gtaacaagtg aaagcccagt
    15061 acctcagaca gaaaaagttc tcgttggtta tgcagatgca ggagtattca gaaagtttga
    15121 ctttggatac aagagctcaa atgctacagg ctttgagaga atcctcgcag atgactatag
    15181 ctcggcaaga ggcttcggat gggaagaagg cacaggttca actgttaact ggaataaggt
    15241 tggcgtagga attgagaatg ctggtgatac tcagacacct atcgagaaag catgttgcga
    15301 tcttgacaga agagacaatg
//
