LOCUS       c00113_NZ_BBIR..       13821 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_BBIR01000046.1 Pseudomonas japonica NBRC 103040 = DSM 22348
            strain NBRC 103040, whole genome shotgun sequence.
ACCESSION   NZ_BBIR01000046
VERSION     NZ_BBIR01000046
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 01:47:56
            Original ID  :: NZ_BBIR01000046.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13821
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13821
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1461:3821]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1462..3821
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..13821
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13821
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             complement(25..1188)
                     /locus_tag="ctg113_1"
                     /transl_table=11
                     /translation="MTLDPPTLLVLSIVLAATASAYLAVEWRSVRESSLLFWSAGFATI
                     SIGSTLALMRMNGLLLLGIWFANGLLVTAHWLFLLGVARFTETRLSRAWYLIFVLWVAL
                     LALPDAPWWSNVMTFANSGLVGVLALRASLLLRPHGNSLSIGAVQLRYVMLSHGAFYCI
                     KALLAVMPGALLDLASFRGEIIQVSLVEGAVALMLIALSMTGSERYRREKRIARLAARD
                     PLTALYNRRALEVRAPRLLENVSAQQPGALLLIDIDNFKLVNDLHGHAAGDRLLVSLSE
                     MILAKIPEDALAARLGGDEFLILLGNTSRERIVALGNALREQFQQEAVSAFDTPEPVTL
                     SIGANLFEQPPVSLAALIEQSDAALYESKRGGRDSIRLVDRTASNPT"
     CDS             complement(1462..2445)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg113_2"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 2.4e-27, bitscore:
                     87.4, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 7.5e-15,
                     bitscore: 46.2, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VINVGSAFLNMSVLRACIDTGVAYLDTAIHEEPGKICETPPWYGN
                     YEWKHLEECQQKNITAILGVGFDPGVVNAYAALAKQQYFDRIDSIDILDVNAGSHGKYF
                     ATNFDPEINFREFTGQVWSWQNSQWTSNTMFEVKRTDDLPVVGSQNLYLTGHDEVHSLS
                     KNLDVPNVRFWMSFGEHYINVFTVLKNLGLLSEQPVKTAEGLEVVPLKVVKAVLPDPAS
                     LAPGYTGKTCIGDLVKGSKDGQPREVFIYNVADHEEAYAETDSQGISYTAGVPPVAAAL
                     LVARGQWDVQRMVNVEELPAEPFLHALDVMGLPTRVKDENGDRPWA"
     CDS             complement(2724..3821)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg113_3"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 1.2e-09,
                     bitscore: 29.2, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VIKTPYYLIDKQKLLGNLEKIAYVREKSGAKALLALKCFATWSVF
                     DLMQQYMDGTTSSSLYELKLGRQKFEGETHAYSVAWADDEIEEMLANCDKIIFNSIGQL
                     QRFAEASEGKVRGLRVNPQVSSSDYLLADPARPFSRLGEWDPVKVEGVIEQISGFMFHN
                     NCENGDFELFDKMLGTIEERFGHLLHKVEWVSLGGGIHFTGEGYALDAFCERLKSFSET
                     YGVQVYLEPGEAAITNSASLEVTVLDTLFNGKHLAVVDSSIEAHMLDLLIYRLNAKMAP
                     NDGEHTYMVCGKSCLAGDIFGEYQFDRPLAIGDRLSFVDAAGYTMVKKNWFNGLKMPSI
                     VVKQLDGSVEVVREFGFEDYLSSLS"
     CDS             3934..4194
                     /locus_tag="ctg113_4"
                     /transl_table=11
                     /translation="VLAFGWVSGCKMLRELGWVGWTAGKMRGALASDEVRKAKQIPHVD
                     GTYIDSGALPPGDCPVIDPDCLAAPSSTGLTRVKPRRTRAR"
     misc_feature    3970..3972
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="gutsmash"
     misc_feature    4093..4095
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="gutsmash"
     CDS             4221..4664
                     /locus_tag="ctg113_5"
                     /transl_table=11
                     /translation="MIYPVLLTLHLFAAIVFIGTVFFEVLFIGGIRQQLPDRLMMMLEH
                     AIGQRARRLMPWVLLVLFGAGAGMVRERYLAQLAAPLDSPFGTLLGLKILVALSVLGHF
                     VTALWLFRSGRMTATAVRFIHASVFTHLLLIVLLAKGMFYLSW"
     CDS             4681..5868
                     /locus_tag="ctg113_6"
                     /transl_table=11
                     /translation="MQVIDRKKAMAIAPLWRLAFRPFFLGGSLLALLVLPLWLVALSGK
                     LEWAPAGGWLAWHRHELLFGFGLAIVAGFLLTAVQTWTGQPGLSGKRLAALALVWLAGR
                     LAWLGAAPWPLLVLLELGFPLLLAGLMGRTLWKVRQQRNYPLVALLLLLTLVDGIAMAG
                     VVHGNDGWQRQGVLGGLWLVAAMMGLIGGRVIPFFTQRGLGRATAVQPWAWLDWLLLGG
                     SALVAVLYATGLALRPGVLVGGLFAALAIGHGIRLLRWHDRGLWRVPLLWSLHLAYAWL
                     AVACAGMALWHFGVALNPSLAVHCLTVGGMAGLILAMIARVSLGHTGRPLEPPKGMTLA
                     FVLLNLAGLARVLLVPLHTHVGLGLATLCWTVAFGLFIRGYAPMLVRARVDGHPG"
     CDS             5944..7164
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg113_7"
                     /sec_met_domain="Radical_SAM (E-value: 6.9e-09, bitscore:
                     27.1, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLIAKLGILADAAKYDASCASSGAPKRSSKGRDGLGATNGMGIC
                     HSYTPDGRCVSLLKVLLTNFCLYDCQYCVNRRSSNVPRARFSPEEVVRLTLDFYRRNCI
                     SGLFLSSGIIRSADYTMEQLVRVARLLREEHGFRGYIHLKTIPDADPLLIEEAGRLADR
                     LSVNIELPSDASLRRLAPEKQVSSIRRAMGTIHRGQQAVAGEARAPRFTPAGQSTQMIV
                     GADASDDRTILRNAESLYQGYGLKRVYYSAFSPIPDSPDSVPLAAPPLLREHRLYQADF
                     LMRGYGYKAGELLSEANNLALDIDPKLAWALSHREVFPVDINRAEPALLARVPGIGLRS
                     VQRLVALRRERRVRYDDLIQLRCVLDKARPFIVTSDYRPVLGEMRSGLLRARLREPQAP
                     VQMGLWG"
     CDS             7161..8027
                     /locus_tag="ctg113_8"
                     /transl_table=11
                     /translation="MIALDCDDTFATWRDQARVLLGHGIDPAEVNWGQGPIQDLLAQPD
                     ALPRGPGPFRARVPVQLLEQLQLAARYRGEQRWNLLYEVLWRVAHGDRTAMLAGDRLGS
                     ELQRRIRQVTREAHHLHAFVRFVPLPTLLAERLQLDLVAFHEPAHDILESASDHFAERL
                     GRQRWLIATSRDGIRYDGAQFDYRRQCPEAWRQWAREADDPDADLWLTYYRHTFNPARV
                     NPDALRLHMPGRFWRHLPEGPLIPRLVGLARQGKQRDGQAQEVAEQGGKRIRYAEPRAS
                     DMPILTR"
     CDS             8034..8735
                     /locus_tag="ctg113_9"
                     /transl_table=11
                     /translation="MHKADRLFQLVNLIRVHQPITAERLAERIGVSVRSIYRYIDDLSL
                     SGVPVYGTTGVGYALDAAFEMPPLRLSRIEVDALTLGMEMLAGSADPQLAGAARTLLSK
                     VSAIAPEQRSDTRQSPVRATGSADATTRGHLSSLRQAIEHKRVLQITYTSLDGAVSHRL
                     IQPIGLFYWGGKWTVGSWCNTRAAYRDFRVDRIASIITSEAPWHDGPQIALRTYMRHQS
                     SHWRTDNRASG"
     CDS             9255..9929
                     /locus_tag="ctg113_10"
                     /transl_table=11
                     /translation="MGRFELGVIEVLLQHGANPNWQATAESSDLVAAHVYGVSGYSSDA
                     PDFVSGPQMGELAFRHGYRPDARALQSIKSFVALDENPRARIKMNVKAFYDQLWNASSA
                     QVKADFQALEAASEALAQQRKREAMDEAEKERLAEENRQRQRAQQESLRVASLRELGTR
                     ICTNRSSDRGWVTYVGYVENLGPRKVQIRVAQAFYQDAPSLAPGDFRPSILWDDLSTWQ
                     SC"
     CDS             10021..10470
                     /locus_tag="ctg113_11"
                     /transl_table=11
                     /translation="MRERKSARLLIVDPEQRVLLFHFVHTDDALAGHSHWATPGGGLEE
                     GEGFREAAIRELREETGIEVADVGEPVGERRFVMRLPSGEDVISMELYYGVRATSQQLS
                     RDGWTAHEMKVMAAHRWWSAEELRGTTETVYPQQLLEMLERARDA"
     CDS             10463..11020
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg113_12"
                     /sec_met_domain="Isochorismatase (E-value: 6.2e-39,
                     bitscore: 124.7, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEDNAALLIVDMQKGIANPAGVRRNNPDAEQQVEALLRAWRTSR
                     RPVVHVRHISRSADSVFRPGQVGCEFQEALAPLGNEQVFEKNVPDAFVASGLERWLHVR
                     GIRQLVVCGVATNNSVEATARTGGNLGFDVVVVADACYTFDLLGRDGRCWAAAEVHALS
                     LDNLAMDYARVLDTRDVLNAAF"
     CDS             complement(11190..12053)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     0.3; E-value: 2.5)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg113_13"
                     /sec_met_domain="LysR_substrate (E-value: 7.3e-33,
                     bitscore: 104.4, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 4.6e-23, bitscore: 71.9,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VQDLQIDWLKCFVAVVDTGSLSKAAPEVHRSQSAVSMQLKKLEAA
                     LGRQLLVRDARQQQLTADGQVLLGYARRILDLHSDAQNAFHGDELTGRIRLGVPDDYAA
                     RYLTPVLKRFALRYGAVEIELDCEQSTSLIPRIDQGDLDLALVSRDHSRRGTLLFREPM
                     VWVGSPQFDVWRRDPLPIATYESTSQARRCAIHSLALQGRDYRVVYNSSSLAGQIAAVE
                     SGLAVAVLTRCSAPEHLEILGAEHGLGPLEPMEVAVYRSRASHGSKPVDQLYGLLIKTL
                     RRVAVS"
     CDS             12207..12926
                     /locus_tag="ctg113_14"
                     /transl_table=11
                     /translation="VLSVAKGSTELGYNEVWDGFRQLLPISMFVVVFGLAFGLAAAQVG
                     LDSPTIMWMSTLVFAGASQFAALDLWGAQVPLVPLIVTVFAINARHLLMGATLYPWLRE
                     LPVARRYGIMLVVSDANWAMAMQALSAGKPGLGILFGGGLALWSTWILGTWLGLYFGNL
                     VSDPVSWGLDMVMGCFLLSMVVGGKKDLRVLLIWAVAAGSALLAYRFLPENSHVVVGAL
                     AGGIVGAVWMEKRKDEH"
     misc_feature    12210..12212
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="gutsmash"
     CDS             12916..13224
                     /locus_tag="ctg113_15"
                     /transl_table=11
                     /translation="MNIETSGHGPLILVLIMAAVTLATRWGGVFVMSFVPINYRVQQFI
                     GAMSGSVLVAVLTPLAVSGDNGARVALASTAVVMLLVKKPLPAIAAGIVAAALFRHF"
ORIGIN
        1 ttccgattgc ccgcgatgag gccctcaggt cgggttgctg gccgtccggt ccaccagcct
       61 gatgctgtcc cgccccccac gcttggactc gtacagcgcc gcgtcgctct gttcgatcag
      121 cgccgccagg ctcaccggcg gctgctcgaa gagattggcg ccgatgctca gggtcaccgg
      181 ttccggggtg tcgaaggcgc tgacggcttc ctgctggaac tgctcgcgca gggcgttgcc
      241 gagggcgacg atgcgctccc gggaggtatt gcccaggagg atcaggaact cgtcgccgcc
      301 caggcgcgcg gccagcgcgt cttcggggat cttcgcgagg atcatctcgc tcaggctcac
      361 cagcagacgg tccccggccg cgtgaccgtg gaggtcgttg accagcttga agttgtcgat
      421 atcgatcagc agcagggcgc ctggctgctg cgccgagacg ttttccagca ggcgcggtgc
      481 gcggacttcc agggcacggc ggttgtacag ggcggtcaac gggtcgcggg cggcgaggcg
      541 ggcgatgcgt ttctcgcggc ggtagcgttc gctgccggtc atcgacaggg cgatcagcat
      601 cagcgccacg gcaccttcga ccagtgacac ctggatgatc tcgccgcgga acgaagccag
      661 gtcgagcagg gcgccgggca tcaccgcgag cagtgccttg atgcaataga aggcgccatg
      721 gctgagcatc acataacgca actgcacggc gccgatgctc agcgaattgc catggggacg
      781 cagcagcagg ctggcgcgca gggccagcac gccgaccagc ccggagttgg cgaaggtcat
      841 cacgttcgac caccagggcg cgtcgggcag cgccagcagc gcgacccaga gcacgaagat
      901 caggtaccag gcacgcgaca ggcgggtctc ggtgaaccgc gcgacaccca gcaggaacag
      961 ccagtgggcg gtcaccagca aaccgttggc gaaccagatg ccgagcagca gcaggccgtt
     1021 catgcgcatc agggccaggg tcgagccgat gctgatggtg gcgaatccgg cgctccagaa
     1081 cagcagggag gattcgcgca cactgcgcca ttccacggcc agataggcgg aggcggtcgc
     1141 ggcgagcacg atgctgagca ccagcagggt aggtggatcg agcgtcatgg gctgacgggc
     1201 ctttcttgtt gactacgaaa tgggcgggat tgtaagcggt tgaaacgttt ttcggagcac
     1261 tgcgctgcgt ttcatctgca ccccccctgt aggagctggc ttgcctgcga aggaccgcac
     1321 agcggtccca gacttcaccg ccatcaggga ccgctgtgcg gtccttcgca ggcaagccag
     1381 ctcctacagg gggggcaggc tgggtggaaa cgaaaaaggg gcgcctgtat gggcgcccct
     1441 tcttttcagc tcatgaacct atcaggccca cggacgatca ccgttctcgt ccttgacccg
     1501 ggtcggcaga cccatcacgt cgagggcgtg gaggaacggc tcggccggca gctcttcgac
     1561 gttgaccatg cgctgcacgt cccactggcc acgggcgacc agcagggccg cggccaccgg
     1621 cggcacgccg gcggtgtagg agatgccctg gctgtcggtc tcggcgtagg cttcttcgtg
     1681 gtcggccacg ttgtagatga agacttcgcg cggctgaccg tccttgctgc ccttgaccag
     1741 gtcaccgatg caggtcttgc cggtgtagcc aggcgccagc gaggccggat ccggcagcac
     1801 ggccttgacc actttcagcg gcaccacttc caggccttcg gcggtcttca ccggttgctc
     1861 ggagagcagg ccgaggttct tcagcacggt gaacacattg atgtagtgct cgccgaagct
     1921 catccagaaa cgcacgttgg gcacgtcgag gttcttcgac agcgagtgca cttcatcgtg
     1981 gccggtgagg tagaggttct gcgaaccgac caccggcagg tcgtcggtac gcttcacttc
     2041 gaacatggtg ttgctggtcc actggctgtt ctgccagctc catacctgtc cggtgaattc
     2101 acggaaattg atttccggat cgaagttggt ggcgaagtat ttgccgtggg acccggcatt
     2161 gacgtcgaga atgtcgatcg agtcgatgcg gtcgaaatac tgttgtttcg ccagcgccgc
     2221 gtaggcgttg accacacccg ggtcgaaacc gacaccgaga atggccgtga tgttcttctg
     2281 ctggcactct tcgaggtgtt tccactcgta gttgccgtac cagggcgggg tttcgcagat
     2341 cttgcccggt tcttcgtgga tcgcggtgtc caggtaggcg acaccggtat cgatgcaggc
     2401 acgcagcacc gacatgttga ggaaggcgga accgacgttg atcacgatct gcgattgagt
     2461 ctcgcggatc agcgccttgg ttgcctcgac atcgagggca ttgagcgaga aggcctggat
     2521 gtcggcgggt accttgaggc tacccttggc cttgacgctg tcgatgatgg cctggcattt
     2581 ggagatgttc cgcgacgcaa tcgcaatacg accgagctcg tcgttgtgct gcgcgcactt
     2641 gtgggccacc accttggcga cacctcctgc accaatgata agaacgttct tcttcaattc
     2701 tctatctctc cttatctgcc agctcaggaa aggctggaca ggtagtcttc gaaaccgaac
     2761 tcacgaacca cctcgacgct accgtcgagt tgtttcacta cgatggacgg cattttcagg
     2821 ccgttgaacc agtttttctt gaccatggtg taacccgcgg cgtcgacgaa cgacagccga
     2881 tcgccgatgg ccagcggacg atcgaattgg tactcgccga agatgtcacc ggccaggcac
     2941 gacttgccgc agaccatgta ggtgtgctcg ccgtcgttgg gggccatctt ggcgttgagg
     3001 cggtagatca gcaggtcgag catgtgcgct tcgatcgagc tgtcgaccac ggcaaggtgc
     3061 ttgccgttga acagggtgtc gagaaccgtg acttccagcg aggcgctgtt ggtgatcgcc
     3121 gcttcgcccg gctccaggta gacctgcacg ccgtaggttt cggagaacga cttgaggcgt
     3181 tcgcagaagg cgtccagggc atagccctcg ccggtgaagt ggatgccgcc gccgaggctg
     3241 acccattcga ccttgtgcag caggtggccg aagcgttcct cgatggtgcc gagcatcttg
     3301 tcgaacagct cgaagtcgcc gttctcgcag ttgttgtgga acatgaagcc ggagatctgc
     3361 tcgatcacgc cttcgacctt gaccgggtcc cattcgccga ggcggctgaa cggacgcgcc
     3421 gggtcggcca gcaggtagtc ggagctgctc acctgcgggt tgacccgcag accgcggacc
     3481 ttgccctcgg atgcctcggc gaagcgctgc agctggccga tggagttgaa gatgatcttg
     3541 tcgcagttgg cgagcatctc ttcgatctcg tcgtcggccc aggccacgct gtaggcgtgg
     3601 gtctcgcctt cgaacttctg gcggccgagc ttgagctcgt agagcgagga cgaggtggtg
     3661 ccgtccatgt actgctgcat caggtcgaac accgaccagg tggcgaagca cttgagtgcc
     3721 agcagggcct tggcaccgga tttctcgcgc acgtaggcga tcttttccag gttgcccagc
     3781 agcttttgct tgtcgatgag gtagtacggg gtcttgatca cttcgaggct ccaggtaggc
     3841 cagccaaaaa aagagccgca ttgtgcccgt actcgataca tatcgaaagg gcgggatgcg
     3901 ctttttgcgc tgtcaatggg ccggctgcct gccgtgctgg cgtttggctg ggtgtcgggt
     3961 tgcaaaatgt tacgcgagct ggggtgggtt gggtggaccg ccgggaagat gcgaggggct
     4021 cttgccagcg atgaagtccg aaaggcaaag cagatcccgc acgttgacgg cacctatatt
     4081 gatagcggtg cgttaccgcc aggtgactgt ccggtcattg atccggattg cctcgccgcg
     4141 ccgagttcca ccggcttgac gagggtcaag ccgcgccgga cgcgagcgcg ctagtctgcc
     4201 gggcacaatg aggccccgcc atgatctatc ccgttctgct gaccctgcat ctgttcgccg
     4261 ccatcgtgtt catcggcacg gtatttttcg aagtgctgtt catcggcggg atccgccagc
     4321 aattgcccga ccggctgatg atgatgctcg aacacgccat cggccagcgc gcccgccggc
     4381 tgatgccctg ggtgctgctg gtgctgttcg gggccggcgc gggcatggtc cgcgagcgtt
     4441 acctggcgca actggcggcg ccgctggact cgccgttcgg caccttgctc ggcctgaaga
     4501 tcctggtcgc cctcagcgtg ctcgggcatt tcgtcacggc gctgtggttg tttcgcagcg
     4561 gccgcatgac ggcgacggcg gtgcgtttca tccacgccag cgtctttact catctgttgc
     4621 tgatcgtgct gctggccaag ggcatgttct atctgagctg gtgaaccggg ggagcccgcc
     4681 atgcaagtga tcgaccgcaa gaaagccatg gcgatcgcgc cactgtggcg cctggcgttt
     4741 cgcccgttct tcctcggcgg cagcttgctc gcgctgctgg tgttgccgct gtggctggtg
     4801 gccctgagcg gcaagctgga gtgggcgccc gccggcggct ggctggcctg gcaccggcat
     4861 gaactgctgt tcggtttcgg cctggcgatc gtcgccggct ttctgttgac cgcggtgcag
     4921 acctggaccg gccagccagg cctgagcggc aagcgcctgg cggccctggc cctggtctgg
     4981 ctggcggggc gcctggcctg gctgggggcg gcaccctggc cgttgctggt gctgctggaa
     5041 ctgggctttc cgctgctgct ggcggggctc atgggacgca ccttgtggaa ggtccgccag
     5101 cagcgcaact acccactggt ggcgctgctg ctgttgctga ccctggtgga cggcatcgcg
     5161 atggctggcg tggtccacgg caacgatggc tggcaacgcc agggtgtgct cggcgggctg
     5221 tggctggtgg cggcgatgat gggcctgatc ggcggccggg tgattccgtt ctttacccag
     5281 cggggactgg ggagggcgac ggcggtgcag ccctgggcgt ggctggactg gctgctgctg
     5341 ggcggttcgg cgctggtcgc ggtgttgtat gcgacgggcc tggcgctgcg gcccggtgtc
     5401 ctggtcggcg ggctgtttgc cgcgctggcg atcggtcatg gcatccgcct gttgcgctgg
     5461 catgatcgcg gcctgtggcg ggtaccgctg ctgtggtcgc tgcacctggc ctatgcctgg
     5521 ctggcggtgg cctgcgcagg catggcgctg tggcatttcg gcgtggcgct gaacccgagc
     5581 ctggccgtgc actgcctgac ggtgggcggc atggccggac tgatcctggc gatgatcgcc
     5641 cgggtcagtc ttggccacac cggacgcccc ctggagccgc ccaagggcat gaccctggcc
     5701 ttcgtcctgc tcaacctggc cgggctcgcc cgggtgctgc tggtgccgct gcatacccac
     5761 gtcggtctgg ggctggcgac gctgtgctgg accgtggcgt tcggcctgtt cattcgcggc
     5821 tacgcgccga tgctggtgcg ggcgagggtg gacgggcatc ccggctagat cgacgacagg
     5881 cgcttgcatc cttgccaatc tcgaaatact gtatggatat tcagtattcg ggaagcgctc
     5941 cccatgcaac tcatcgccaa gctcggcatc ctcgccgacg ccgccaagta cgacgcttcg
     6001 tgtgccagca gtggtgcccc caagcgcagc tcgaagggcc gcgacgggct tggcgcgacc
     6061 aatggcatgg gcatctgcca cagctacacc ccggacggcc gctgcgtgtc gctgctcaag
     6121 gtgctgctga ccaacttctg cctgtacgac tgccagtact gcgtcaaccg ccgttccagc
     6181 aatgtcccgc gggcgcgctt cagccccgag gaagtggtgc gcctgaccct ggatttctat
     6241 cggcgcaact gcatcagcgg gctgttcctc agttccggga tcatccgttc ggcggactac
     6301 accatggagc aactggtgcg ggtcgcccgg ctgctgcgtg aggaacatgg ctttcgcggc
     6361 tacatccacc tcaagaccat ccccgacgcc gatccgttgc tgatcgagga agccgggcgc
     6421 ctggccgatc gcctcagcgt caatatcgag ctgcccagcg atgccagcct caggcgcctg
     6481 gccccggaaa agcaggtgag cagcatccgc cgggccatgg gcaccatcca ccgtggccag
     6541 caggcggtgg ccggcgaggc gcgggcgccg cgcttcaccc cggcggggca gagcacgcag
     6601 atgatcgtcg gcgccgatgc ctcggacgac cgcaccatcc tgcgcaatgc cgaatcgctg
     6661 tatcagggct atggcctcaa gcgcgtgtac tactcggcgt tcagcccgat cccggacagc
     6721 cccgacagcg tgccgctggc ggcgccaccg ctgttgcgcg agcaccgcct gtaccaggct
     6781 gatttcctca tgcgcggcta tggctacaag gctggcgaac tgctcagcga ggcgaacaac
     6841 ctggccctgg atatcgatcc caagctggcc tgggcgctgt cccatcgcga ggtgtttccg
     6901 gtggatatca accgcgccga gccggccttg ctggcgcggg tgccgggcat cggcctgcgc
     6961 agcgtgcagc gcctggtggc gctgcgccgc gagcggcggg tgcgctacga cgacctgatc
     7021 cagttgcgct gcgtgctgga caaggcgcgg ccgttcatcg tcaccagcga ctatcgcccg
     7081 gtgctggggg agatgcgcag cggtctgctc cgtgctcggc tgcgtgagcc gcaggcacca
     7141 gtgcagatgg ggttgtgggg atgattgccc tcgactgcga cgacaccttc gccacctggc
     7201 gcgaccaggc gcgggtactg ctcgggcatg gcatcgaccc ggccgaggtc aactggggcc
     7261 agggaccgat ccaggacctg ctggcccagc ccgatgcact gccgcggggg cccggaccgt
     7321 tcagggcgcg ggtgccggtg cagttgctgg agcagttgca gctggctgcc cgctatcgcg
     7381 gtgagcagcg ctggaacctg ctctacgaag tgctctggcg cgtggcccat ggcgaccgta
     7441 ccgccatgct cgccggcgac cgcctgggca gcgagttgca acggcggatc aggcaggtca
     7501 cccgcgaagc ccatcacctg cacgccttcg tgcgtttcgt gccgttgccg acgctgctgg
     7561 ccgagcgcct gcaactggat ctggtggcct ttcacgaacc ggcccacgac attctcgaaa
     7621 gcgccagcga ccatttcgcc gaacgcctgg ggcggcagcg ctggctgatc gcgacctcgc
     7681 gcgatggcat ccgctatgac ggtgcgcagt tcgattaccg ccgccagtgc cccgaagcat
     7741 ggcggcagtg ggcgcgggag gcggacgacc ccgatgccga cctgtggctg acctattacc
     7801 gccacacctt caacccggca cgggtcaacc ccgacgcctt gcgtctgcat atgcccgggc
     7861 ggttctggcg gcacctcccg gaagggccgt tgatcccgcg gctggtgggc ctggcccggc
     7921 agggcaagca gcgggatgga caggcgcagg aggtggcgga gcagggtggc aagagaatcc
     7981 gatatgccga gccgcgcgcc agcgatatgc cgatactcac gaggtaattc tccatgcaca
     8041 aagccgatcg cctgttccag ctggtcaacc tcatccgcgt gcaccagccg atcaccgccg
     8101 agcgcctggc cgagcgcatc ggcgtgtcgg tgcgctcgat ctatcgctat atcgacgacc
     8161 tgtccctgag tggtgtcccg gtgtatggca ccacgggcgt tggctacgcc ctcgacgccg
     8221 ctttcgagat gccaccgctg cgcctgagcc gcatcgaggt cgacgcgctg accctcggca
     8281 tggaaatgct cgccggcagc gccgacccgc aactcgccgg cgccgcgcgg accctgctga
     8341 gcaaggtctc ggccattgcg ccggagcagc gcagcgacac gcggcaaagc ccggttcgcg
     8401 ccacgggcag cgccgatgcc acgacccgcg ggcacctcag cagcctgcgc caggccatcg
     8461 agcacaagcg cgtgctgcag atcacctaca ccagtctcga cggcgccgtg tcgcaccgcc
     8521 tgatccagcc catcggcctg ttctactggg gcggcaagtg gaccgtcggc agctggtgca
     8581 acacccgtgc ggcctatcgc gatttccgcg tcgaccgcat tgcctcgatc atcaccagcg
     8641 aagcaccctg gcatgacggc ccgcagattg ccctgcgcac ctacatgcgt catcaatcga
     8701 gccactggcg taccgacaac agggcgtcag gatgacctgc tgatcactcc cgacgtttcg
     8761 tgtgcaagac agcctgttgc ctggggcatg gcagattcgc ttgaagcgtc atgagtgatg
     8821 tcgttgtgat atcgtcgctg cgtatatctc gattttcact tcagcaagga tcgttggctg
     8881 tgaagcacat tgttcccttc gcgttatcac tgtttctgat tggatgtggc acgacttcgg
     8941 aaaatcgtga aaagaccgcc gagtcggctc aggctctgcg taactgtctc tcggccaccc
     9001 actttgaacc caagtaccag gcttgccaca gccaccgtct ggaaggcacg gcgtccaacc
     9061 aggctcggga gcactggagg caattcctga gcgagcaagg gccggatata cgcctgctgg
     9121 ggggcatcta tggatacaac ctcgacgccg tcaaggcagc gatcgccgcg ggcgcaaacg
     9181 tcaaccgcga gtacagccca gaggcgacga cgggacggcc aacgggacgg aacaccaccc
     9241 cgctcgatca agcgatgggt cgattcgagc tcggcgtgat cgaagtgctg ctgcagcatg
     9301 gcgccaatcc gaattggcaa gcgaccgcgg aatcctccga tctcgttgcc gcgcatgtct
     9361 atggggtcag tggttattcg agtgacgcgc ccgatttcgt ttctggtccg caaatggggg
     9421 agctcgcgtt tcgccatggt taccgtcccg acgccagggc gctccaatcc atcaagtcgt
     9481 tcgtcgcgtt ggacgaaaat ccccgtgccc gcatcaagat gaacgtcaag gcgttctacg
     9541 accagctctg gaatgcgtcg agcgcacaag tcaaggccga cttccaggcc ctggaagccg
     9601 ccagcgaggc gctcgcccaa caacgcaagc gcgaggccat ggacgaggct gaaaaggaac
     9661 gtctcgcgga ggaaaaccgc cagcggcaac gcgcgcagca ggaaagcctg cgggtcgcga
     9721 gcctgcgcga actcggtacc cgtatctgta ccaatcgcag cagcgaccgc ggttgggtca
     9781 cctacgtggg ttatgtcgag aacctggggc cacgcaaggt ccagatccgc gtggcacaag
     9841 cgttctacca ggacgctcca tcgctcgcac cgggtgattt ccggcccagc atcctgtggg
     9901 acgacctgag cacttggcag tcctgctgac gcatgcccga ttcgcgtgat gatgaccgcc
     9961 gcttctggca tcatcgcgcg ccaatcgaac atcgttgctg cccacaagga ccctgctgtc
    10021 atgcgtgaac ggaaatcagc ccgcctcttg atcgtcgacc ccgagcagcg ggtgctgctg
    10081 ttccatttcg tgcacaccga tgacgcgctg gcggggcact cgcactgggc cacccccggt
    10141 ggtggcctgg aggagggcga ggggttccgc gaggcggcga tccgcgaact gcgcgaggag
    10201 accggtatcg aggtcgccga cgtgggtgag ccggtcggcg agcgacgctt cgtcatgcgc
    10261 ctgcccagcg gcgaggacgt catttcgatg gagctgtatt acggcgtgcg ggccacctcg
    10321 caacagctca gccgcgacgg ctggaccgcg catgagatga aggtgatggc ggcgcatcgc
    10381 tggtggtcgg ccgaggaact gcgcggcacc accgagacgg tgtatccgca gcaactgctg
    10441 gagatgctgg agcgtgcccg tgatgcttga ggacaatgcc gcactgctga tcgtcgatat
    10501 gcagaaaggc atcgccaacc ccgcgggtgt ccggcgcaac aatcccgacg cggagcagca
    10561 ggtcgaagcc ttgctgcgag cctggcggac gtcgcggcga ccagtggtgc atgtgcggca
    10621 tatctcgcgt tccgcggact cggtgtttcg accggggcaa gtgggttgcg aattccagga
    10681 ggcgctggcg ccgctgggga acgagcaggt gttcgagaag aacgtgccgg atgcctttgt
    10741 cgcctcgggc cttgagcgct ggctgcatgt gcgcgggatc cgccagcttg tggtgtgcgg
    10801 ggtggcgacc aacaactcgg tggaggccac ggcgcgcacg ggcggcaacc tggggttcga
    10861 tgtcgtggtg gtggcggatg cctgctacac cttcgatctg ctcgggcggg atggccggtg
    10921 ttgggcggcg gcggaggtgc atgcgctctc gctggacaac ctggcgatgg attatgcgcg
    10981 ggtgctggac actcgggatg tcttgaatgc ggctttctga tgccatgcga tagtcctgta
    11041 ggagctggct tgcctgcgaa cgggcgcgaa gcggccgcaa aactgtgagc gcggcgtgtc
    11101 aggcatgcct gggactcagg ttttgcgacg gctgcgccgt cgttcgcagg caagccagct
    11161 cctacaaggg atcgcattcg ctctggtaat caggacacgg ccaccctccg caaggtcttg
    11221 atcagcaacc catacaactg atccaccggc ttcgacccgt gcgatgcccg gctccgatac
    11281 accgccactt ccatcggctc cagcggtccc aggccatgct cggcaccgag gatttccaga
    11341 tgctccggcg cgctgcagcg ggtcagcacc gccaccgcca ggccactttc caccgccgcg
    11401 atctgcccgg ccaggctgga gctgttgtac accacccggt aatcccgccc ctgcaaggcc
    11461 agcgagtgaa tggcacagcg ccgcgcctgg ctggtgcttt cataggtggc gatgggcagc
    11521 ggatcacgac gccagacatc gaactgcggc gagccgaccc agaccatcgg ctcacggaac
    11581 agcagggtgc cgcgccgtga atggtcgcgg gataccaggg ccagatccag gtcaccctgg
    11641 tcgatgcgcg gaatcagcga ggtggattgt tcgcagtcca gctcgatctc caccgcgccg
    11701 tagcgcaggg cgaagcgctt gagcaccggg gtcaggtagc gcgcggcgta gtcgtccggc
    11761 acgccgaggc ggatgcgccc ggtgagctcg tcgccatgaa aggcattctg cgcatcgctg
    11821 tgcaggtcga ggatgcgccg cgcataaccc agcagcacct ggccatccgc ggtgagttgc
    11881 tgctggcgcg catcgcgtac cagcaactgg cgacccagcg ccgcctccag cttcttcaac
    11941 tgcatgctca ccgccgattg cgagcggtgc acctcgggcg cggccttgga cagcgagccg
    12001 gtgtccacca cggcgacgaa acacttgagc cagtcgatct gcaggtcctg cacgggcacg
    12061 ctccgatgta ttcgataagc gaatgggtta gtcgcgtaat atgcgctttt cgcaatgctg
    12121 tgtctgctgg atagtgactg gcgtccgaat gctgcgttcg agtaacagcg ctccgccgga
    12181 cggagcgcca aagaaggaga agggttgtgt tatcggttgc caagggctcc acggagctgg
    12241 gctacaacga ggtatgggac gggttccggc agttgttgcc gatctcgatg ttcgtcgtgg
    12301 tgttcggtct ggccttcggc ctggccgcgg cccaggtcgg gctggattca ccgacgatca
    12361 tgtggatgag caccctggtc ttcgcgggcg cgtcgcagtt cgccgccctc gatctgtggg
    12421 gcgcgcaggt gccgctggtg ccgttgatcg tcaccgtgtt cgccatcaat gcccgccatc
    12481 tgctgatggg cgcgacgctc tatccctggc tgcgcgagct gccggtggca cggcgctacg
    12541 ggatcatgct ggtggtgtcg gacgccaact gggcgatggc gatgcaggcg ctgagcgccg
    12601 gcaagccggg cctgggcatt ctcttcggcg gtggcctggc gctgtggtcg acgtggattc
    12661 tcggtacctg gctcggcctg tacttcggca acctggtcag cgacccggtg agctggggcc
    12721 tggacatggt catgggttgc ttcctgctgt cgatggtggt gggcggcaag aaagacctgc
    12781 gcgtgctgct gatctgggcg gtcgccgccg gttcggcgtt gctggcgtac cggttcctgc
    12841 cggagaacag tcatgtggtg gtcggtgccc tggccggtgg catcgtcggt gcggtgtgga
    12901 tggagaaacg caaggatgaa cattgaaacc agcgggcacg gcccgctcat tctggtcctg
    12961 atcatggcgg cggtaaccct ggcgacccgc tggggcgggg ttttcgtgat gtccttcgtg
    13021 ccgatcaact accgcgtgca gcagttcatc ggcgccatgt ccggctcggt gctggtggcg
    13081 gtgctgacgc cgctggcggt gagtggcgac aacggcgcga gggtggcgct ggcgagcacc
    13141 gcggtggtga tgttgctggt gaagaagccg ttgccggcaa tcgccgcggg gatcgtggcg
    13201 gcggccttgt tccggcattt ctgagcaatc tcccggggcc tgccgcgccg cacggcggcc
    13261 cctcgtgcca accgctggct atctgccaac ctgcgattat tcttacagct gcgtgcaacg
    13321 cgaggccgtc cgcctgttcc aggcccggcg cagtccgtaa tccgatgtca tcagcctttc
    13381 gaatggccag agtgcgtgcg gaatcaatag cgggatgctc cggcctacaa gaacaagacg
    13441 gagaacattc atggcggtca tgagcggcac ttcatccccg ggcagcacgt ccggcaagaa
    13501 catcacccac gacgagcgca aggtcatctt cgcctcgtcc ctggggacgg tcttcgagtg
    13561 gtacgacttc tacctgtacg ggtccctggc ggcgatcatc gccaagcact tcttcgccgg
    13621 ggtcaatgaa accaccgcgt tcatcttcgc cctgctggcc ttcgccgccg gttttgcggt
    13681 acggccgttc ggcgccatcg tcttcggacg cctgggcgac atgatcgggc gcaaacacac
    13741 cttcctcatc accatcatca tcatgggcgt gtccactgcc atcgtcggcc tgttgcccag
    13801 ttacgccagc atcggcgtgg c
//
