LOCUS       c00109_NZ_AFGF..       14385 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_AFGF01000115.1 Acetonema longum DSM 6540 Contig00120, whole
            genome shotgun sequence.
ACCESSION   NZ_AFGF01000115
VERSION     NZ_AFGF01000115
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 01:23:03
            Original ID  :: NZ_AFGF01000115.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14385
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14385
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1851:4385]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1852..4385
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..14385
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14385
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(94..321)
                     /locus_tag="ctg109_1"
                     /transl_table=11
                     /translation="MAWHGADRQDPLLPALHMLRLTASQAPHPVSFASRSVASLSLISL
                     LLVYSLSREYSWIVYTDIVADSRAKSFFKY"
     CDS             complement(438..635)
                     /locus_tag="ctg109_2"
                     /transl_table=11
                     /translation="MVNGDTDNLSVILTFFYVIIPFRNVGSAVFLDKRFQRDNFFMLIG
                     QAGPAEHHYTFIVSVELVRQ"
     CDS             complement(705..866)
                     /locus_tag="ctg109_3"
                     /transl_table=11
                     /translation="VALSNVKCGVSNCRYWESGQRCNASAIEVHTDNGSGQANQSRETN
                     CKTFETTR"
     CDS             complement(957..1862)
                     /locus_tag="ctg109_4"
                     /transl_table=11
                     /translation="LISNSLTIIPFYLSNPLNRCHGSGHRHLFKGCFIIAARNLLQNSS
                     VASNLRPFGLQEGIFRRERECNGKALVTLRLCTAKEGFGVINYIRIWRLFLLTLLLTSW
                     IIKGPALAAPDPLAAAIDSPVRLTAEQVYVAAARVIRQERMFRLLIGLIAIGVVLSVIM
                     WRRNRAGFKRELAKSQDVLRPALLYDVQKVSGQSVFTLSKPLVSIGQAVEEGRNGVDIP
                     LPITNLAAVQAVLEYRTGAFYLVNYNEGVALTVNGLPVLDEARLKSGDQICIASRPFRF
                     LVPGDKEYTDQRRQCGLGDC"
     CDS             complement(1852..2619)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: 102.1; E-value: 5.3e-32)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg109_5"
                     /sec_met_domain="Fer2_3 (E-value: 3.1e-32, bitscore: 102.1,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 9.6e-11, bitscore: 33.3,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00016, bitscore: 13.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSISKSEAKTVRLIIKRQDSPETAPYTQEFVVPYSDNMNVVTAL
                     MEIQKNPVTSDGKEVNPVAWDCNCLEEVCGACTMIINGKARQSCSALIDQLEQPIRLAP
                     LTKFPVVRDLIVDRSRMFEALKKVKAWINVDGTWDLGPGPRMAQKNQEEVYPLSRCMTC
                     GCCMEACPNFNDKSDFLGPAPISQVKLFNAHPTGNLQKDERLTALMGPGGLAACGNAQN
                     CVAACPKSISLTKSIADLNRQVNRFALSKLFDQ"
     CDS             complement(2622..4385)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 305.3; E-value:
                     2.5e-93)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg109_6"
                     /sec_met_domain="FAD_binding_2 (E-value: 1.5e-93, bitscore:
                     305.3, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 7.2e-42,
                     bitscore: 133.7, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIKFIVIGGGAAGLTATMRIAEQGHKVDLFSIVPVKRSHTGCAQ
                     GGINAAMNTKGQGDSTQQHFIDTVVGGDFLANQPPVKALCDAAPGVIHMLDRMGMMFTR
                     TSEGILDLRPFGGTKHKRTAFSGATTGQQLLYTLDEQVRRYEDKGLVKKYEGWEFLSAV
                     LDEAGECRGIVAQHLSTMEIEVFAADAVILATGGIGMVFGRSTNGTISTGSAASIAYQQ
                     GAYYANGEFIQIHPTALPGEDKRRLMSESARGDGGRIWTYKDGKPWYFLEEWYPAYGNL
                     VPRDVAARAIFKVCVEMGLGIDGKNIVYLDVSHIDSKELDRKLGGILEIYEKFIGEDPR
                     KVPMKIFPSMHYTMGGLWTDYSHMTSIPGLFAAGECDYMYHGANRLGGNSLMSATYSGM
                     VAGPAAVNFVKGRQRTPVSSALLEAAKQKEIAAFEQLMKMNGTENPYVIHREMGDWMTE
                     NVTIQRFNAKLQETDNKLQELEERWEKVGVSDHSCYSNQVVMFTRQLHHMLKLSRVITQ
                     GALRRNESRGSHFKPEFPERDDENWLKTTKAAYSADGPVFSYEPVDTSLLAPRARRYDV
                     DNNSAAKKEAK"
     CDS             complement(4422..5027)
                     /locus_tag="ctg109_7"
                     /transl_table=11
                     /translation="LNQTDFYLRRLHSLTGIVPVGFFLLEHIFTISRRIAGSAAFDAAV
                     DFLQNMPMKAGLEIGFIALPLLFHGIYGLYAAFAAKNNVATYGYFRNWTFYMQRITAYI
                     AFLFIIWHVWLLRLGGAGLGAVTNAKTLSTVLQDPIVFSLHMIGYIATVFHFTNGIWAF
                     LITWGITTGSRAQLTSQYLCWGLFVLLNIVGLTAMMYF"
     CDS             complement(5030..5584)
                     /locus_tag="ctg109_8"
                     /transl_table=11
                     /translation="MSQKRITTPLTEETARSLKAGDSVLITGVIYTGRDAAHKRMVETL
                     DKGEALPVDMRDQIIYYVGPAPAKPGQPIGSAGPTTSGRMDAYTPKMLAQGLRGMIGKG
                     YRSAEVVEAMKKYGCVYLAATGGAAALIAKTIKKYEVMAYEDLGTEAIAKLTVEDFPAI
                     VVIDSQGNNFYEEGQKPYRRL"
     CDS             complement(5599..6444)
                     /locus_tag="ctg109_9"
                     /transl_table=11
                     /translation="MRTVEAKVITAAIAKLCIDANYYLSPDVYDALVAGKEKEESPLGR
                     EILGQLVDNACIARNQAMPICQDTGMAVVFMEIGQDVHITGGDLEAAVNAGVVQGYKEG
                     YLRKSVVNDPMFVRKNTGDNTPAILHLSIVPGDKIKITIAPKGFGSENMSAVKMLTPSA
                     GVAGVKKFVTDTVTAAGSNPCPPMVVGVGIGGTFEKAAFLAKKALLRPINKHNADPMYA
                     KLEEELLELVNKTGVGPQGLGGTITALGVNVEYYPTHIAGMPVAININCHATRHAEIEI
                     "
     CDS             6614..6937
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     64.6; E-value: 2.1e-20)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg109_10"
                     /sec_met_domain="HTH_1 (E-value: 1.2e-20, bitscore: 64.6,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELRQLECFHMVCQTNNFTRTAEKLHIAQPSVTNAIRNLETELGI
                     RLFNRTTKKSVINAGRAGVFAPGGKNPAGNAGSGQRNGRLLPVEARWHQNSRAPDDWRL
                     FVP"
     CDS             7017..7562
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg109_11"
                     /sec_met_domain="LysR_substrate (E-value: 7.4e-41,
                     bitscore: 131.0, seeds: 361, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEREELDLGIIILPEHSDNLNTIPIVQETIVLCVAPTHRLSREN
                     QVSFKQLKNEEFILLKEDSYHRQVIMEQCQIYQFQPRVIFSSTQIQTIKALVSSGAGIS
                     FLMQRVVAQDAPQIISLPLAEPITINIGLAWKKDKYLSKASQAFIEFIHEYTQSPDFHN
                     PWRLLPQSFPPCKMKELS"
     CDS             complement(7661..9625)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transketolase_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transket_pyr"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transketolase_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg109_12"
                     /sec_met_domain="Transketolase_C (E-value: 1e-16, bitscore:
                     52.2, seeds: 80, tool: rule-based-clusters)"
                     /sec_met_domain="Transket_pyr (E-value: 6.3e-52, bitscore:
                     167.0, seeds: 81, tool: rule-based-clusters)"
                     /sec_met_domain="Transketolase_N (E-value: 2.8e-156,
                     bitscore: 510.7, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLAVDAIEKAKSGHPGMPMGAAPMAYVLWNKFLRHSPLNPAWPDR
                     DRFVLSAGHGSMLLYALLHLTGYDLPLEELKKFRQWESRTPGHPEFSYTAGVETTTGPL
                     GQGLANAVGMAIAERHLAARFNRPGYDIVDHYTYTIVGDGCLMEGISHEAASLAGTLKL
                     GKLICLYDDNHISIEGSTDIAFGDDSLKRFEAYGWQVLAVKDGNDLTAIEAAIEQAKKD
                     NARPSLIAVRTEIGYGSPGKQGKASAHGEPLGESEVALVKEGFGWPKEPSFYVPDEAAR
                     HFQAVAEQNNQQEQAWQKLFASYATGFPELAAEWQRGLEGQLPDNWDQDLPVYPPSAKG
                     MATRAASGEALTAIAGKVPNLIGGSADLAPSTKTYMKGLGDFSAANPAGRNMRFGVREH
                     GMGSVMNGMALHGGLIPFGATFLAFADYMRPPIRLAALMRQKAVYVFTHDSIGLGEDGP
                     THQPIEQVASLRVIPELTVIRPADANETVEAWRYAMESQEGPVALIFTRQNVPVIDRSR
                     YESHGDLFQGAYIVDKGGVKPDVILMGTGSELHIALEAAAKLKEKGITARVVSMPSWEL
                     FDEQPSEYRDMVLPPSIGARIAIEAGSTQGWHKYVGDKGEIVGMDHFGASAPAEILYEK
                     FGITAEHLVNRAVKLCRGK"
     CDS             complement(9913..10743)
                     /locus_tag="ctg109_13"
                     /transl_table=11
                     /translation="MEIRTAVSPRDIKAYTTERMREEFLIQDLLLPGKIKMVYSHVDRI
                     IAGGARPAEPIALQAGKEIGADFFLQRREMGIVNIGPAGTVMVDGTEYRLEKSDGLYVS
                     MGSKDLVFSSDDPKNPAKFYFNSCPAHAAFPTKKILKKDIKGNHLGSIQQSNERTIYKY
                     IDPQAGAKSCQLVMGMTVLEPGNMWNSMPCHTHDRRMEVYFYFDLPENAVVFHLMGEPA
                     ETRHIVMRNEEAVISPSWSIHSGVGTASYTFIWGMCGENQNFDDMDHVPMAILK"
     CDS             complement(10934..11950)
                     /locus_tag="ctg109_14"
                     /transl_table=11
                     /translation="MMLKRSCQAGETVLFWFHMIVGWGSPIMNQFVPVYVFLVMATFLW
                     GVQPVIVKTLLTELSPLWITFCRYLGISVILLAILFFSNGKAAVPPARHFRVLALMGIT
                     GITLNNVLQFSGLKFSTAMHCSLVSATTPALTAVISAIFLREKISRIQWTGIMISFFGV
                     TFLVAHGSIDAILHLSFNYGDILFLGSQICWAVYSILGRSVMRELSPVTVTAWAGLAGT
                     VATGPLLFWDGGHGVSRMTSTGVLSLLYMVIGGGILAMTWWNSGVKTLGPTKAAIFINI
                     MPLVGMTFAVSFLGEHLGWREILGGLSIISGVCLMTQSDHLSDWFKNLKRVESSVRH"
     CDS             complement(12191..12850)
                     /locus_tag="ctg109_15"
                     /transl_table=11
                     /translation="LKGLFIPKRLQNLRLALMAGIGAGFLTAILVLTLGKGTNPYVWNV
                     ANFLGGLGNDLFLVSTNLLIIGWALRRNLKSLIKLILGLDLTVWIVVQAIKLFPVAAWA
                     LRPDGTIGGFPSGHTTHAFAMGFVLTLLFPRFWWFWYSCSMAISWSRVESSWHTDMQVI
                     AGIFLGLGIAWVLISLWSKHPDADRMPGQGRVPYRRPERSWPYGWLNRRNRELPQE"
ORIGIN
        1 tcttaaaatt gatattcctt ttgttacgcc ttgtgcgttt ttaataaatt ctacaagcag
       61 ccgtacatct ccctgccgat aaactaaact tttttaatat ttaaagaagc ttttggctcg
      121 tgaatctgct acaatatcag tatatacaat ccatgaatat tccctgctca atgaataaac
      181 cagaaggagt gaaatcaatg aaagcgatgc gacgctccga gaagcaaatg acacgggatg
      241 aggcgcttga cttgctgtca gccggagcat atggagtgct ggcaacagtg gatcctgacg
      301 gtcagcccca tgccacgcca ttgaactatg tgctggtcaa tggcgtttta tactttcact
      361 gcgcctggga aggcgtgaag ttgaacaata tccggcacaa cgctaaggtg ggttttaccg
      421 tggtcgggcg cagccagcta ttgccggacc aattcaacac tgactatgaa agtataatgg
      481 tgttcggccg ggccggcctg gccgatgagc atgaaaaaat tatcgcgttg aaagcgcttg
      541 tccaaaaata cagcgctgcc tacattcctg aagggtatga ttacatagaa aaaagtcagg
      601 atcacactca ggttgtccgt atcaccattg accatatttc cggtaaacac aagctatagt
      661 gtaaaaagaa acagacccgg cgccgccggg tcatttgctt cttatcatct ggttgtttca
      721 aaggtcttac agttggtttc gcggctttgg ttagcctggc cgctgccatt gtccgtatgg
      781 acctcaatag cggaagcgtt gcaacgctgg ccggactccc aatacctaca gttggatacg
      841 ccgcatttta cattcgacaa tgccactgat cctcacctcc taaaaaatag tctccaaata
      901 gtatgtgagg atttgtatct cttattctgt gcaaaaagat tcaaatgcct ttctgttcaa
      961 cagtctccca gcccgcattg ccgccgttga tcggtatact ccttatcgcc ggggactaaa
     1021 aaacgaaagg gacggctggc gatgcaaatc tgatcgccgg atttcagacg ggcctcatcc
     1081 agtaccggaa gcccatttac cgtcagggca accccttcgt tatagttgac caggtaaaaa
     1141 gcgccggttc tatattccag cacggcctgt acagcagcaa ggttcgtaat gggcagggga
     1201 atatccactc cgttgcgacc ttcttccaca gcctgaccaa tagaaaccag cggtttagaa
     1261 agggtaaata ccgactgacc gctgaccttc tgtacgtcat ataacagagc cggccgcagg
     1321 acatcctgtg acttggccaa ttctcgctta aaacccgcgc gattccgtcg ccacataata
     1381 actgacagca caacgccgat agcgatcagg ccgatcagca gacggaacat cctctcctgc
     1441 ctgatgaccc gtgctgcggc cacatagacc tgctcagccg tcagcctgac cggactgtca
     1501 atggcagctg ctaaagggtc tggcgccgcc agggccggcc cctttatgat ccagcttgtt
     1561 aagagtaatg tcagcaagaa taagcgccat atcctgatat agtttatcac gccgaatccc
     1621 tcctttgcgg tacacagtcg taatgtaacc aaagctttcc cgttacattc ccgctcccgg
     1681 cgaaaaattc cttcctggag accgaacggt ctcagattcg aggccacaga tgagttttgc
     1741 aacagattcc tagcggctat aataaaacac cctttaaaca gatgtctatg gcctgagcca
     1801 tggcatctgt ttaaagggtt tgacagatag aaaggaatga ttgtgagcga gttactgatc
     1861 aaacagtttg cttaacgcaa accgattgac ctggcggttc aggtcggcaa tagacttggt
     1921 cagggaaatg gatttggggc aggctgccac acagttttgg gcattgccgc aggcggccag
     1981 gccgccgggt cccatcagcg ccgtcaatcg ttcatccttt tgcaggttgc cggtgggatg
     2041 ggcgttaaac agtttgacct ggctaatggg cgccgggccg aggaagtcgg atttgtcatt
     2101 gaagttcggg caggcttcca tgcagcagcc acaggtcatg caacgggaaa gaggatatac
     2161 ttcttcctga tttttctgag ccatacgcgg ccccggcccc agatcccagg tgccgtccac
     2221 attgatccag gccttgactt ttttcagtgc ctcaaacatc cggctgcggt ctacaatcag
     2281 gtcccgcacc accggaaatt tggtcaaagg agccagacga atgggctgct ccagttgatc
     2341 aatcaaggcg gagcaagact gccgggcttt gccgttaatg atcatcgtgc aggcgccgca
     2401 tacttcttcc agacagttgc agtcccaggc aaccgggttt acttccttgc cgtcgctggt
     2461 gaccggattc ttttgaatct ccatcagggc agtgaccaca ttcatattat cgctgtaagg
     2521 cacgacgaat tcctgggtat aaggcgccgt ttccggactg tcctgacgct tgataatcaa
     2581 acgaactgtt tttgcttctg atttcgatat cgatgtcatg gttacttggc ctccttcttg
     2641 gcggcggagt tgttgtcaac atcatagcgc cgcgcccgag gcgctaacag cgacgtatca
     2701 accggctcgt aggagaagac cgggccatcg gcggaataag ccgccttggt ggttttcagc
     2761 cagttttcat catcccgttc cgggaactcg ggtttaaagt gtgaaccgcg gctttcattg
     2821 cgccgcaaag cgccctgggt gatgaccctg gaaagcttga gcatatgatg gagctgccgg
     2881 gtaaacataa ccacctgatt ggaatagcag gagtggtcgc tgacgccgac cttttcccag
     2941 cgttcttcca gttcctgcag cttattgtca gtttcctgca atttggcgtt aaagcgttga
     3001 atcgtcacat tctcggtcat ccagtcgccc atttcccggt gaatcacata gggattctcg
     3061 gttccgttca ttttcataag ctgctcaaag gcggctattt ctttttgttt ggcggcttcc
     3121 agcaacgcgg aggaaaccgg tgtccgctgg cggcctttga cgaagtttac ggctgccgga
     3181 ccagccacca tgccgctgta tgtggcggac attagagagt tgcctcccag ccggttggcg
     3241 ccatgataca tatagtcgca ctcgccggcg gcaaacaagc cgggaatgct ggtcatatga
     3301 gaatagtccg tccacagtcc gcccatggtg taatgcatgg aagggaaaat cttcatgggg
     3361 actttgcggg gatcttcccc gataaatttt tcatagattt ccaggatgcc gcccagcttg
     3421 cggtccagtt ccttcgagtc aatatgggaa acatccaggt agacgatatt cttgccgtcg
     3481 atgcccagtc ccatttccac acatactttg aatatggctc tggccgccac gtcccggggt
     3541 accagattgc cgtaggcagg ataccattct tcgaggaaat accagggttt tccgtcttta
     3601 taggtccaga tgcggccgcc gtcaccccgg gccgattcac tcatcaggcg ccgtttgtcc
     3661 tcacccggca gagcggtggg gtgaatctgg ataaactcgc cgttggcgta gtatgctccc
     3721 tgctgatagg caatcgaggc agccgatccg gtgctgatag tgccgttggt gctgcgtccg
     3781 aataccatgc cgataccgcc ggtagccaga atcaccgcat cagcggcaaa aacctcaatc
     3841 tccatggtgc tcaaatgctg ggccacaatg ccgcggcact ccccggcctc atccagcaca
     3901 gcagacaaaa attcccatcc ttcgtacttt ttgaccaagc ctttatcttc gtaacgacgt
     3961 acctgctcat ccaaagtgta cagaagctgc tgaccggtgg tagcgccgga aaaggcggta
     4021 cgtttatgtt tagtgccgcc gaaaggcctc aggtccagta tcccttccga tgtccgggta
     4081 aacatcatgc ccatgcggtc cagcatgtga atcacgccgg gtgcggcatc gcacagcgct
     4141 tttaccggcg gttgattagc aagaaaatcg ccgcctacaa cagtgtcgat aaaatgctgc
     4201 tgggtggaat ccccctgacc cttggtattc atagcggcgt tgatgccacc ctgagcacag
     4261 cctgtatgag agcgtttcac cggcacgatg gaaaatagat ctactttatg tccctgctcg
     4321 gcaatgcgca tggtagccgt caggccggca gcgccgccgc cgattacgat aaatttgatg
     4381 ctcatagttt gctccttcct agtagactaa agcttagaaa ctcagaaata catcattgct
     4441 gtcaggccga cgatgttcag cagcacaaac agcccccagc agagatactg actggttaac
     4501 tgcgcccggg aaccggttgt aataccccag gtaatcaaaa aggcccatat cccgttggta
     4561 aagtggaata cagtggcaat atatccaatc atgtgaaggg aaaaaacaat gggatcctgc
     4621 agcacggtgg agagggtctt agcgttcgtc acagcgccca gacccgctcc acccaagcgc
     4681 agcagccata cgtgccaaat aatgaaaaga aatgcgatat aagcggtgat ccgctgcata
     4741 tagaaggtcc agttccgaaa atagccgtaa gtggcaacat tgtttttggc ggcaaaagcc
     4801 gcatataagc cgtagatgcc gtgaaataag agaggaagag cgataaagcc aatctccaga
     4861 cccgctttca tcggcatatt ctgcagaaaa tccaccgctg cgtcaaaggc ggctgaaccc
     4921 gctattctgc gggagatagt gaagatgtgt tccaagagaa aaaagcctac aggcactata
     4981 ccggtcaggg aatgaagccg gcgcaaataa aaatctgtct ggttcaacgt tataacctcc
     5041 gatatggttt ttgtccttct tcgtagaagt tattgccctg actgtcaatc accactatag
     5101 ccggaaagtc ttctaccgtg agtttggcaa tcgcttctgt tcctaaatct tcataagcca
     5161 ttacttcata ctttttgatg gtcttagcga tcaaagcagc cgcgccgcct gtagcggcca
     5221 aatacacaca gccatatttt ttcatagctt ccacgacttc cgccgaacgg tatcccttgc
     5281 caatcatacc ccgcaaccct tgagccagca ttttgggagt ataggcatcc atgcggccgc
     5341 tggtggtagg tccggcagac ccgataggct gaccaggctt agccggagca ggacctacat
     5401 aataaataat ctggtcgcgc atatcaaccg gcagagcctc gcctttgtcc agagtctcca
     5461 ccatccgttt atgagccgca tcccgcccgg tgtagatcac accggtaatc agcacgctgt
     5521 caccggcttt taacgagcgg gcagtttctt cagtcagagg ggtcgtaatc cgtttttgtg
     5581 acatagccca cacgctcctt atatttcaat ttccgcatgc ctggtggcat gacagttaat
     5641 attgatagca accggcatac cggcgatatg ggtaggataa tattccacat tgacacccag
     5701 agcggtaatt gtcccgccta acccttgagg acccacgccg gttttgttga ccagttccag
     5761 caattcctcc tccagtttag cgtacatcgg atcggcatta tgcttgttaa tcggccgcaa
     5821 caaagccttt ttcgccagaa aggcagcttt ttcaaaggtg ccgccgatcc caacgccgac
     5881 gaccatgggc ggacagggat tagacccggc agcggtcacc gtatcggtga cgaatttctt
     5941 cactccggct acgccggcgg aaggggtcag cattttcacc gcgctcatat tctcactgcc
     6001 aaagcctttg ggagcgatgg tgattttaat tttgtcgccg ggaacgatgg agagatgcag
     6061 gatggccggc gtattatccc cggtattttt gcggacaaac atcggatcat tgaccactga
     6121 ttttcgtaaa tagccctctt tatagccctg gactaccccg gcattcaccg cagcttccaa
     6181 atcgccgcca gtgatgtgaa catcctgtcc gatttccata aaaaccacgg ccataccggt
     6241 gtcctggcag ataggcatgg cttggtttct ggcgatacag gcattgtcca ccaattgccc
     6301 cagaatttct ctgcccaggg gcgattcttc cttttccttg ccagcaacca aagcatcgta
     6361 gacgtccgga gacagatagt aattggcgtc aatgcaaagt ttagctatgg ctgccgtaat
     6421 gactttggcc tctactgtac gcataataac cctcctattt taaaattttc aagcactatg
     6481 tatccttgtt ataaatgtaa catgcactat gattcattta aaatatcttt tttctatgat
     6541 atgataagaa gtagctatga caagttaaat cgattctgaa aacttctgtc ccagaagcga
     6601 aacgaggtgc agaatggaac ttcgacagtt ggaatgtttt cacatggttt gccagaccaa
     6661 taactttacc cgtaccgccg aaaaattgca tatagcccag ccttcggtca cgaatgccat
     6721 tcgaaacctg gaaacggaat tgggcatccg gctatttaac cgcacgacaa aaaaaagtgt
     6781 cattaacgcc ggaagggcag gtgtttttgc gccgggtgga aaaaatcctg cgggaaatgc
     6841 gggaagcggt cagagaaatg gacgactttt gccagttgaa gcgaggtggc atcaaaatag
     6901 ccgtgccccc gatgattggc gcttatttgt tccctgacat tttcacccat tttaagaatt
     6961 cacacccttt cctggacctg ctggtctttg aggaaggatc ccttgcagcc cgcgcaatgc
     7021 tggaacggga agaattagac cttggcatca tcatcctgcc ggaacactcg gacaatctca
     7081 acactatccc tatcgtccag gaaaccatcg tgttatgcgt ggcccccacc catcgcctga
     7141 gccgggaaaa ccaggtttct ttcaagcaac tgaaaaatga agaatttatt cttctgaaag
     7201 aggattccta tcatcggcag gtcattatgg agcaatgcca aatctatcag ttccagcccc
     7261 gcgtcatttt ttcctctact cagatccaaa cgatcaaagc cctggtctct tccggcgccg
     7321 gcatctcttt tctcatgcag agggtggtgg cccaagatgc gccgcagatt atcagtctgc
     7381 cgttggcaga gcccattacg atcaacatcg gtttggcctg gaaaaaagac aagtacctgt
     7441 ctaaggcttc acaggcattt attgaattta ttcatgaata cactcaatcc ccggattttc
     7501 ataacccttg gcgtcttttg ccccagtcat ttccgccttg caagatgaag gagctgtctt
     7561 aataaaaaaa ggaaggcacc cacccgtcat ggcaagaaaa tagatattgt atgcgaaaga
     7621 ggattcatct gcggtagatg aatccccttt cgcattttta ttattttccc cggcagagtt
     7681 ttaccgcccg gtttaccaaa tgctcagccg taatgccgaa tttctcgtaa aggatctccg
     7741 caggggcgga agcgccaaag tggtccatac ccacgatttc gcccttatcc cccacatatt
     7801 tgtgccagcc ctgggtgctg ccggcttcaa ttgcgatcct ggcccctatg gaaggcggca
     7861 gcaccatgtc acgatattca gaaggctgtt catcaaacag ttcccagctg ggcatgctga
     7921 caacccgggc cgtaatgcct ttttccttga gtttagcggc agcttccaaa gcgatatgca
     7981 gttccgaacc ggtgcccatc agaatcacat ccggcttaac gccgccttta tccacaatat
     8041 aagcaccctg gaacagatcg ccatgggact cgtaacggct gcggtcaatc accggcacat
     8101 tttggcgggt gaagatcaag gccacaggcc cttcctggct ttccatggcg taacgccaag
     8161 cttccaccgt ttcattggca tcagccggac ggatgacggt gagttcaggg ataacccgca
     8221 aggaagccac ctgctctatc ggctgatgag tcggaccgtc ttcccccaga ccgatgctgt
     8281 catgggtaaa cacataaaca gctttttgcc gcatcaaggc cgccaggcgg atggggggac
     8341 gcatgtaatc ggcaaacgcc aggaatgtag cgccaaaagg aattaaaccg ccatggagcg
     8401 ccatgccgtt catgacggat cccataccat gctctcggac gccaaagcgc atattgcggc
     8461 cggccgggtt agcggcgcta aagtcaccta aacctttcat atatgtctta gtagatggcg
     8521 ccaggtcggc ggaaccgccg atgagattgg gaactttccc ggcaatagcc gtcaaagcct
     8581 cgccggaggc agctctggtg gccatgcctt tggcactggg cggatagacc ggcagatcct
     8641 ggtcccaatt gtccggaagc tgtccctcta aaccccgctg ccactcagcc gccagttcgg
     8701 gaaaccctgt ggcgtaggag gcaaaaagtt tttgccaagc ctgttcctgc tggttgtttt
     8761 gttcggctac agcctgaaaa tgccgcgccg cctcatccgg aacgtaaaaa gacggttctt
     8821 tcggccagcc aaaaccttct tttaccaagg ccacttcgct ctcacccaag ggctcgccat
     8881 gagcgctggc ttttccctgc ttacccgggc tgccatagcc gatctcggtg cgaacagcaa
     8941 ttagactggg tctggcatta tcctttttag cctgctcaat ggctgcttca atggctgtca
     9001 aatcattgcc gtccttcaca gccaggacct gccagccgta agcttcaaac cgtttgaggc
     9061 tgtcgtcgcc aaatgcaata tcagtactgc cttctattga aatatgatta tcatcataaa
     9121 ggcaaatcag cttgcccagt ttcagcgtgc cagccagaga ggcggcttcg tgggagattc
     9181 cctccatcag gcagccgtcg ccgacgatgg tataggtgta gtgatccacg atatcataac
     9241 cggggcgatt gaacctggcc gccagatgac gctcagcgat agccatgccg actgcgttgg
     9301 ccagaccctg gcccaggggg ccggtcgttg tctccactcc tgccgtgtag ctgaactccg
     9361 gatgtccggg agtccggctc tcccattggc ggaatttttt caattcttcc aggggcaaat
     9421 cataaccggt cagatgcagc agagcataca agagcatcga accatggccg gctgacaaga
     9481 caaaccggtc acggtcaggc caggccggat ttagcggact gtggcgcaaa aatttattcc
     9541 acaggacata agccatggga gcagccccca tcggcatgcc aggatgcccg gatttcgcct
     9601 tttcgatggc atcgaccgcc aacatccgta ttgtgttgac gcacaattgg tcagttgctt
     9661 ggttcattga ataaggtgcc tccttataat catgtgttca tgcggttcag aaaggaaaat
     9721 ggaaccattt gagcaagttt taaaccagat ttctatattc gttgtttccc ggcgaaaccc
     9781 tttccggtta aagcccattt ccccgatttt tacagaaaat caacgcaaaa agggataatc
     9841 tgttctgtaa agattatccc ctaaaacggc tattcccatg ttgccgggaa aatagttttt
     9901 gttttatcca ggctatttca gtattgccat cggaacatgg tccatgtcgt cgaaattctg
     9961 attctcaccg cacattcccc aaataaaggt ataactggcg gttcccacgc cggaatgaat
    10021 ggaccagctg ggagaaatga cggcttcttc atttctcatc acaatgtgcc gcgtttcagc
    10081 cggctcaccc atcagatgga atacgaccgc attctccggc aggtcaaaat aaaaataaac
    10141 ctccatgcgc cggtcatgag tgtgacaagg catactgttc cacatatttc ccggttcaag
    10201 taccgtcatg cccatgacca gctggcaact cttcgctcct gcctggggat caatgtattt
    10261 ataaatagtg cgctcgttgg attgctgaat cgatcccagg tgattacctt tgatgtcttt
    10321 cttcagtatc tttttcgtcg gaaaagccgc gtgggccggg cagctattga aataaaattt
    10381 cgccgggttc ttgggatcgt cactggagaa taccaggtcc ttcgacccca tactcacata
    10441 caacccatca gatttctcca gcctgtactc tgtgccgtct accatcacag tcccggccgg
    10501 tccgatattg acaataccca tttctcttct ttgcaggaaa aagtccgcgc cgatctcttt
    10561 gcccgcctgc agggcaatcg gttccgccgg ccgtgctccg ccggcgatga tccggtccac
    10621 gtggctatat accattttta ttttgccagg cagtaataaa tcctgaatta agaattcttc
    10681 tctcattctt tcggtagtat aggccttaat atctctggga cttaccgctg ttctgatttc
    10741 catggctacc acccctccat cgttgaaaaa tcaataatgc cttttccttt agcctcgggc
    10801 cttttggatt agattatagc ataatttttt caaccttcgc actattaagg cgaaccacat
    10861 ggtgaacttt cgtactatgc catgaaatat cggattcttc cccagcaaga gaaccggacc
    10921 cggaagaagg tgctcagtgg cggaccgaag actcgacccg cttcaggttc ttaaaccagt
    10981 cagataaatg gtcgctctgg gtcatcaggc atacaccgga aatgatcgat aacccgccta
    11041 aaatttcgcg ccagcctaaa tgttccccta agaaacttac ggcaaaagtc atgccgacca
    11101 aaggcatgat attgatgaag atagcggcct tggtcggccc cagagtttta acgccgctat
    11161 tccaccaagt cattgccagg atgccgccgc caatgaccat atacagcagg gataataccc
    11221 ctgtagaggt catccgggat accccatgcc ccccgtccca aaacaaaaga ggccccgtcg
    11281 ccacagtacc ggctaaaccg gcccaagccg taacagtcac cggtgaaagc tcacgcatga
    11341 cgctgcggcc taatattgaa tatacagccc agcaaatttg actgcctaaa aagaggatat
    11401 cgccgtagtt aaaggaaaga tgcaaaatag cgtcgatcga cccatgagcg actaaaaagg
    11461 tgacaccgaa aaaggaaatc ataatgcctg tccactggat cctgctgatt ttctcccgca
    11521 gaaaaatagc gctgatgacc gccgttaatg ccggcgtagt cgccgaaacc agcgaacaat
    11581 gcatggcggt tgaaaatttc aaaccgctaa attgaagaac gttattcaaa gtgataccgg
    11641 tgatgcccat taaagccaga acacgaaaat gccgggccgg aggaaccgcc gctttgccgt
    11701 tcgagaaaaa taaaatggct aacaggatca cactaatacc cagatagcgg cagaaagtga
    11761 tccagagtgg agataattcc gtaagaagtg ttttgactat aaccggctgt acgccccata
    11821 agaaagtggc catcaccaaa aaaacataga ccggaacgaa ttgattcatg attggcgacc
    11881 cccatcccac tatcatatgg aaccaaaaaa gtacggtctc accagcttgg caagaccgct
    11941 taagcatcat ctataaaatg ttctggagcg ggtgatggga atcgaaccca cgcgactagc
    12001 ttggaaggct aggactctac cattgagcta cacccgcaat atgtcttgat caaataaata
    12061 tggtcggagc ggcaggattt gaacctgcga ccccctggtc ccaagccagg tgctctacca
    12121 aactgagcca cgccccgttc aacacgaaaa gtattatact atactgccgg aattaagtca
    12181 agaatctttt ttactcctga ggaagctcac ggtttcgccg gttcaaccag ccatagggcc
    12241 aggatctttc cggccgtctg tagggcacgc gtccttgccc gggcatccgg tccgcatcag
    12301 gatgcttact ccataaggag atcagtaccc aggcaatgcc taaccccaaa aagataccgg
    12361 ctatcacctg catatccgta tgccagcttg actctacccg tgaccaggat atagccatac
    12421 tgcaagaata ccaaaaccac caaaacctcg gaaaaagcag ggtcaacaca aaacccattg
    12481 caaaagcgtg ggtggtatga ccgctgggaa agccgccgat ggtaccgtca gggcgcaggg
    12541 cccaggcagc aacaggaaag agtttaatgg cctgaacgac gatccagaca gtgagatcca
    12601 gtcccagaat caatttgata aggcttttaa ggtttcttcg caaagcccag ccaatgatca
    12661 gcaaattggt actgaccaga aaaagatcat ttcctaaacc gccaagaaag ttagccacat
    12721 tccatacata aggattcgtt cctttgccta atgtcaagac gagtatggcc gtcaggaagc
    12781 cggcgccaat tcccgccatc aaagccaatc gcagattctg caatcgtttt ggtataaaaa
    12841 gtcctttcaa agcctgtata ctcctctcac aacatttgac gttgttcaat gaccgtatgg
    12901 cataggataa ccatacatta aattgcgggc ataataccaa ttcaggcgga gttcctctcg
    12961 gccttgccgg ttgatggcga cactgcccaa aggggatatg gattgaaaat aaggtccata
    13021 ttgctgcagc acccgctcgg tcacggcagg tctgccgata atgacagcat ccttccccag
    13081 catagaaccg atggggcgaa tgaaggcgaa gtgatggggt tcatctgaca agcaaactac
    13141 cggcagcttc ccgctcaggg cataatcaat cttgccggca tcaatccaat gaggggcgat
    13201 cacaaacaat tcagcctgat gctcttgagt cagaaaacct tttgccgcaa aagccggccg
    13261 gacttcccgc caatcatacg cttccataga agggtccccc tgagggaaga gcgacggatt
    13321 cattgttttc aaccaaccgg tggccgtgtg cgaagccaga acggcaatca gcaaaataaa
    13381 aacaagagcg gaaagcctca gccaaaccgc tgtttttcga ttatgacagg ccagtcggtt
    13441 agcaaccact ctccccagca agggaaacaa aaagagatat cccggcgcct gccagtgaaa
    13501 caggccttcc gccccgcata gggtcaagaa ggtaaaaatc agaatgggac cggctgccaa
    13561 acaggataaa aaccagcgtt ttgactgttc cggagtgctg cccggacctc ccaaaccact
    13621 ggtaatccag gacccaacca gcggcagcca gatccaggga agcacccagg ccgcctgccc
    13681 ggcaatattg cccatcattc gtccggggta ccagcccttg gctaagcccc ggctgccctg
    13741 aaacgcaaaa gatgcccagt catgctgcca gttccagatc aaaaccggcg agaaaataag
    13801 aagtccgatg cctaatgcca gatagggacc ggccgttaaa agcaaggggc gatgcgtacg
    13861 ggatgtaatg ataaagagga aagcgccgaa ggcgataaaa acagcatgat atttgctgag
    13921 aagtcccagc cccaaaagaa cccccgctgc caaccaccag aacagagacc gttcctgcgt
    13981 cgggtcaaat agaagctgga ccagtaccag cacacaggcc agcataaaaa acatcaaggg
    14041 tccgtccggc aagatccaac cgccggtact gagactaaat acagccgaaa gattcatgat
    14101 caaggcggcg taaacgccgg cccaattgcc gaaaagaacg gcgcccagcc tgtacatcag
    14161 ccaggtagtg gcagcaaaca gcaaaataaa cggcaaccgc agcagaatgc cataatctgt
    14221 gccgaaaatc ttgccagcca gccctatcaa ccagaaatgc aacggcggat gatcgaaata
    14281 actcaatgtc cagattcgtg atacagccac agcgtaagat tcatcaacgc ctaatccaat
    14341 ggttaagccg aggacgaccc tgaataagag gccgccaaga attaa
//
