LOCUS       c00024_NZ_CALK..       16839 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CALKQY010000024.1 MAG: Hoylesella shahii isolate
            ERR589682_bin.108_CONCOCT_v1.1_MAG ERZ773040.10, whole genome
            shotgun sequence.
ACCESSION   c00024_NZ_CALK..
VERSION     c00024_NZ_CALK..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 00:51:52
            Original ID  :: NZ_CALKQY010000024.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 123155
            Orig. end    :: 139994
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16839
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[133155:136672]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13517
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..16839
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16839
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             447..1526
                     /locus_tag="ctg24_94"
                     /transl_table=11
                     /translation="MALALALSSSTMPLHAEKGTGQNLLTSSTFNAFQTPWISAPQTDS
                     TSMLWFTRIYKQTSRPRKAFVSVATTGKIQLLVNGMNVSRNLYEPFRRYADTTEVNIRY
                     DITPFLARNNTISLWYCPTMPHAGRKQVAISYWGELADGTPFAYNSDETWACRRANRGM
                     QWASAYQQNPSSHQQDVSSHQQDISSDRQVSSSGQQYPSSGMLFPLAEWHNATDNATPW
                     QINLADSIPWLSASRYNATHIAPLAQPLQLIPAPRVIKVFSPEVQNTKSDTLIYRFPHH
                     FQGIVRITFRGTRRGGNIYINHLRYICNGATDEQAFSKFTLTDNLNLIIHGDKHFRLKS
                     VQNVEALEIRIVLYRKFLF"
     CDS             1622..2500
                     /locus_tag="ctg24_95"
                     /transl_table=11
                     /translation="MRKLQLNDLTIPIVKESCDVVSMDDDLIFVDDLNKLSDLSGPYKM
                     QCLVLAICAQGSAQYTVDTITYELQPNHILVVPAGPILNSGELSTNCKGVAILLSKDFM
                     NEIIMGIHELSSLILFSRTNPVFTLNAEEGGEMLLHLSLIEKKMQQAGHRYRKDTVRSM
                     ITSMIYNASDAIYRVQQTTDLKKTRAEAIFAKFIKMVEQNFRKERRVSWYGEQLGITPK
                     YLSETVRNVSKRTPNQWIDKYITLELRVQLKNTTKSVKEIAKELNFPNQSFLGKFFKEQ
                     VGLSPSQYRKR"
     CDS             3303..3515
                     /locus_tag="ctg24_96"
                     /transl_table=11
                     /translation="MSLGHCHSLGEVYFAPELARRHPYEGRENLLSSTNSFLSCVICAW
                     EHILLVLIGRDARASLFLFYILCGF"
     CDS             complement(4807..5712)
                     /locus_tag="ctg24_97"
                     /transl_table=11
                     /translation="MNNLRRELELLLLLTENKDYSVQMLADRLDITRRQLYYDLENLRA
                     CGFKLVKTNTKYRLDRHSPFFKRLHENIAFTEEEAMMVYRLLDRLPHTDYLSKSIQSKL
                     ERFFNLELLTDVGQRRQAESNAAVLREAIQLRRVVILKNYSSPHSRTVSDRMVEPFLFL
                     NAEMDIRCFEINSHTNKTFKTSRAASVEMTDVEWLNEQSHKSIFTDLFMFSGEERLPVE
                     LKLGRLAHSILLEEYPAAEAYITPANTPNHWIFASEVASYLGIGRFVLGLYHDIDVLGS
                     AQFAAYINEKVKAMNQKVNP"
     CDS             complement(5984..9202)
                     /locus_tag="ctg24_98"
                     /transl_table=11
                     /translation="MALALATTASAQENPLWLRHCAISPDGSTVAFAYKGDIYTVPATG
                     GNARQLTTNSAHDSYPVWSPDSKQLAFCSNREGSMDVYVMNREGGAPRRLTTNSGTETP
                     IAFKDNNTVLYVSSIMPTAQSILFANGSLPQVYEVSTNASRPRLFSALPMMDISIRPNG
                     DLLYHDQKGYEDPLRKHHRSPITRDIWLRRAGKYTKLTNFNGEDRTPVWAAQGDSFYYL
                     SEEDGTFNVYKRNIDGTDKQQLTRHTTNPVRFLTAATDGTLCYGYDGEIYTLKQGAQPQ
                     KLKVNIVTDKTDKDLDRQTLFTGATEISLSPDGKELAFVLHGDVYVTSMDYRTTKQITD
                     TPEQEREIQFAPDGRSIVYASERNGLWQIYRTKLKLDKEKSFAYATQLEEEQLVKSNRT
                     SQQPRFSPDGKCIAFYEDRSTLRVLDIKSKEVRTVMDGKFVYSYSDGDIGFTWSPDSRW
                     LLASYIGIGGWNNPDIALVKADGKGEIHNLTQSGYSDGGPRWVLGGKAMIFSSDRAGYR
                     SHGSWGAERDVYIMFFDLDAYEKFRRNKEERELAKNEEQEQQKDKKDKKDKEEDKIKVG
                     SANKKKKDEPKGLVFDLENCRDRVIRLTDHSSHLGDYVLSNGGDTLYYQASFEGGYDLW
                     KRQISEDRTSIVMKNVGSGEFLPDKDFRHLYLCDYNAIKKIDLSSNSSKNIEFEARFNF
                     KPYAERQYMFNHVWQQVKDKFYEPTLHGVDWANYKKVYEKFLPYINNNFDFSEMLSEML
                     GELNASHTGARYWGTAPRLQTAHLGLFFDNDYTGNGLRVQEVIKRGPFAVRNTKVTAGC
                     IIEKIDGDSIVQGQDYFPLLDGKAGKPVRVSVFDPKTKKRFDVVIRPVSASEQQELLYK
                     RWVDRNRHLVDSLSGGRLAYVHVKAMNSPSYRQVYLELLSDTNRNRDAVIVDERHNGGG
                     WLHDDLCTLLNGKEYQQFVPNGRYVGSDPFNKWNKPSCVMICEDDYSNGHGFPWVYKEL
                     GIGKLIGTPVAGTMTAVWWENMLDPSIVFGIPQVGCRDLRGNYGENTQLNPDIEVYNSP
                     EDYINGYDRQLVKAVEEMMKVVKK"
     CDS             10001..10690
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_99"
                     /sec_met_domain="SucD_FumR (E-value: 4.3e-81, bitscore:
                     263.9, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWLINSSIGRKVVMSVTGVALVLFLTFHMSMNIVALFSEKGYNMI
                     CEFLGANWYAVVATLGLGALTVAHIVYAFILTAQNRRARGNERYAVTSRHEKVEWASQN
                     MLVLGIIIALGLVLHLYNFWYNMMFAELIGVEMKFHPADGFAYIRETFSNPVYVVLYIV
                     WFVAIWFHLSHGFWSAMQSLGVSGKVWFNRWKAIGLAYTTLLMLGFLIVVLAFAFGCAP
                     SLCACCA"
     CDS             10718..12700
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 196.9; E-value:
                     2e-60)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_100"
                     /sec_met_domain="FAD_binding_2 (E-value: 3.4e-60, bitscore:
                     196.9, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 3.6e-36,
                     bitscore: 116.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIKIDSRIPEGPVAEKWTNYKAHQRLVNPKNKLKLDVIVVGTGL
                     AGASAAASLGEMGFNVLNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTVK
                     GGDYRAREANVYRLAEVSNSIIDQCVAQGVPFAREYGGMLANRSFGGAQVSRTFYAKGQ
                     TGQQLLLGAYSALSCQVKAGKVKLYTRYEMEDVVIVDDRARGIIAKNLVTGKLERFSAN
                     AVVIATGGYGNAYFLSTNAMGCNCTAAIQCYRKGAYFANPSYVQIHPTCIPVHGDKQSK
                     LTLMSESLRNDGRIWVPKKIEDAKALQAGQKRGSDIPEEDRDYYLERRYPAFGNLVPRD
                     VASRAAKERCDKGFGVNNTGLAVFLDFSESIERLGIDAIQQRYGNLFDMYEEITDVNPG
                     ELANEINGVKYYNPMMIYPAIHYTMGGIWVDYELMTSIKGLFAIGECNFSDHGANRLGA
                     SALMQGLADGYFVLPYTIQNYLADQAIWPRLSTDLPEFAEAEKGVQDEIDRLMGIQGQR
                     SVDSIHKELGHIMWEHVGMGRTAEGLREGIKKMKELRKEFDTNLFIPGSKEGLNVELDK
                     AIHLRDFIIMGELEAYDALSRNESCGGHFREEYQTEEGEAKRDDENFFYVGCWKYQGND
                     TTEPELIKEPLEYEAIKVQTRNYKQ"
     CDS             12762..13517
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_101"
                     /sec_met_domain="Fer4_7 (E-value: 1.6e-11, bitscore: 37.4,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_3 (E-value: 4.1e-23, bitscore: 74.3,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.7e-05, bitscore: 17.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKNISFTLKVWRQNGPTAKGHFDTFEMKDIPGDTSFLEMLDILN
                     EQLIEARQEPFVFDHDCREGICGMCSLYINGHPHGPATGATTCQLYMRRFKDGDVITVE
                     PWRSAAFPVIKDCMVDRGAFDKIIQAGGYTTVRTGQPQDANAILIPKEDADEAMDCATC
                     IGCGACVAACKNGSAMLFVSSKVSQLALLPQGRPEAAKRAKAMVMTMEELGFGNCTNTR
                     ACEAECPKNESIANIARLNREFISAKLAD"
     CDS             13727..14374
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg24_102"
                     /sec_met_domain="HAD_2 (E-value: 2e-39, bitscore: 128.3,
                     seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIATVILDFDGTLGDSRRIIVDTLRETLRQHNLPVSTEEQCAAT
                     IGLPLKEAFVMLANVDEDTAMKCVNTYRSIFDVNNVTGAVKPFANVVDTIKQMYAAGLT
                     LTIASSRGRDSLPHLAQSIGIGQYISYIVSAEDVVNAKPHPEPVLKTLEHLDAKPQETL
                     VVGDMAFDIEMGRRANTFTCGVSYGNGSVNELEEAGANWVIDDFAQLLNIVF"
     CDS             14599..15819
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAPRTase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg24_103"
                     /sec_met_domain="NAPRTase (E-value: 5.5e-37, bitscore:
                     120.4, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQPILNHFTDNDAYTFSCQYYVLQTYPRAEVEYTFFDRNHTAYPE
                     GFADKVREQINLMQNVRITDEEIAFMQQRMYYLPQWYFTFLRGYKFNPSEVHIEQSAEG
                     QLAISIRGKWYSTIMWEMPVLSIISELMHQHRGDIERYDEALEYERAAEKARQILRGGL
                     ILGDMGTRRRLSFAHHDNVLRAMKATAEAGGETVDGVFQPWKGRIVGTSNVYLAMKYNL
                     VPMGTMSHQIIEFEENVSGIFECNFNVMRKFSDVYDGDNGIYLYDCFGDKVFFNNLSKR
                     MALMFTGLRVDSGVEEEQTEKIIEKYKQLGINPATKKVIFSNGLNIERALEIHRFVDGR
                     VQDSYGMGTFLTCDVVGCKPMNIVVKLTKCRITEKREWHDCVKLSCDKGKTLGNPEKCA
                     YLLKQIG"
     CDS             16042..16587
                     /locus_tag="ctg24_104"
                     /transl_table=11
                     /translation="MTKQLFFLVALALLFSCSSSSDKTYEPTIASAIINSVYLSVQDEK
                     GEVIDQDQLLKDARVQVRGCESRKPLHITSTAIGDVKFLSFSPDLPHREVMRFWDSKEG
                     KRGTGYSDAELTIDGVTMKLRFHYDYAEALNAEKLLGGSSIILKAVECNGKKISVQDHT
                     QFFIITMKKTAGGYELRP"
     CDS             complement(16712..16837)
                     /locus_tag="ctg24_105"
                     /transl_table=11
                     /translation="CCFLTAFIFLSASCLPLQLDVARYACVTKTGNLLYYKTTSV"
ORIGIN
        1 tggcaagcaa agcacggatt tgtattctgc tgcaagtgat attagtagat ggcgttatct
       61 caacacacaa ttcaacgctc cttattaata atgccactca tgcagtgctg tattttcagc
      121 attcattcac ccttctaaat agatggaaac ctcggtagaa cagcggacgt ttgctaaaaa
      181 atggttcaac gcacacacga aattagacag ctgcccgcaa tgccttctca tggaatttag
      241 gacagtgttt gcagactatg tgcacgcggt ggtttcgaag ttaactgcta ttggcgtaac
      301 aaacgcgtac ttgatactcg cataaagaga aaagtagaca aacaaactgc tgtttacgat
      361 aacgacaaaa caaaaaaact taacctcaaa gcggacgagg aggccgtgct aaaatgatat
      421 ttcgtatatg gatgtgtaac ctctgtatgg ctcttgccct tgcgctgagc tccagcacca
      481 tgcctctaca cgcagaaaaa ggcacaggtc aaaacctctt aaccagtagt acctttaacg
      541 cctttcaaac accttggata agcgcaccgc aaaccgactc gacgtccatg ctgtggttta
      601 cgcgcatcta taaacaaacg tcgcgccctc gtaaagcctt tgtgagcgtg gctacaaccg
      661 gaaaaataca gctacttgtt aacggcatga acgtaagccg caacctttac gaaccctttc
      721 gcagatatgc cgacaccaca gaagtgaaca tacgctacga cattacaccc tttcttgctc
      781 gtaacaacac catctccctt tggtattgcc ccaccatgcc ccatgcgggg cgcaagcaag
      841 tggccattag ctattggggc gaactggccg atggcacacc ctttgcctac aatagcgacg
      901 aaacatgggc ttgtagacga gccaatcgcg gcatgcaatg ggcttcagca taccaacaaa
      961 acccctcatc acaccaacaa gacgtttcat cacaccaaca agacatttca tcagaccgtc
     1021 aagtctcttc atcaggccag caataccctt cgtcaggaat gcttttccct ttagccgaat
     1081 ggcataacgc caccgacaat gccactccct ggcaaatcaa cctagccgac agcatacctt
     1141 ggctttcagc ttcgcgctac aacgccaccc atatagcacc attagcccaa cccttacaac
     1201 tcataccagc cccccgtgtg ataaaggtgt tttctccaga ggtgcaaaac accaaatccg
     1261 atacacttat ctaccgcttt cctcatcatt ttcaaggcat tgtgcgtatt acttttagag
     1321 gaactagaag aggaggaaat atttacatca atcaccttcg atatatttgc aatggtgcca
     1381 cagacgagca agcatttagc aaattcaccc ttaccgacaa ccttaacctt atcatccacg
     1441 gcgacaagca ctttcgttta aaaagtgtcc aaaatgtaga agccttagaa atacggattg
     1501 ttctatatag gaaatttctt ttttaataaa taacttattt cgcattttcg tactttttta
     1561 ttctttattg cttgcattta tggtattaat ttcctatatt tgcgaagtaa aaggtaagga
     1621 aatgcggaaa ctacaattga acgacttgac aattcctatt gtcaaagaaa gctgcgacgt
     1681 tgtgagtatg gacgacgatt taatattcgt cgacgacctc aacaagctgt cggacctatc
     1741 aggtccgtac aaaatgcagt gcttggtgct tgccatctgt gctcaaggca gtgcccagta
     1801 cacagtagac acaatcacgt atgagcttca acccaatcac attttggtgg tacctgctgg
     1861 tcccatactt aatagtggtg agctgagcac caactgtaag ggtgtagcca tactgttgtc
     1921 taaggacttc atgaacgaga ttatcatggg aatccatgaa ctttcgtcct tgattctctt
     1981 ctcaagaacc aaccctgtat tcacactcaa tgcagaagaa ggaggcgaaa tgctgctcca
     2041 cctctcgctc attgaaaaga aaatgcagca ggctggccat aggtatcgca aagatacagt
     2101 acgctcgatg ataacgtcga tgatatacaa tgcatcagac gctatctatc gggtacaaca
     2161 aacaacggac ttgaagaaga cacgagccga agccatcttc gccaagttca ttaaaatggt
     2221 agaacaaaac tttagaaaag aacggcgagt aagctggtat ggcgagcaat tgggcatcac
     2281 tcccaaatat ctttccgaaa cagtgagaaa cgttagtaag cgaacaccca accaatggat
     2341 tgataaatat atcaccttgg aactgcgcgt gcaacttaaa aacaccacta aaagcgtgaa
     2401 agaaattgct aaagaactca atttccccaa ccaaagcttc ttaggaaagt tctttaaaga
     2461 acaagtggga ctatctccct cacagtaccg caaacggtaa accgccctca ggtgcatggt
     2521 ttcctttctg caatgtcgcc ccaatattga gtacctcatc gcagattggg ctcggcacat
     2581 gcaccaacga gctggcaagg aaatagagtt agagtaatta gaaaatgttt taggagcaga
     2641 gaattttgag ttagagccta tattaaataa ttaaataaac cacatagata aaattagata
     2701 gaaaaggaac aaagggaata tgagggtgaa cgctgattat attgcagccc tttcgatgca
     2761 atataccaat ctcctcattc ttatctcaat gtgatgtttg ccgtagtgac agcttcttca
     2821 atctcccaat agttgctttt tgtctcacat ataatgccgt gccacatctt agtatatggc
     2881 tgggtaatgc ctacaaccaa ccataatgat ggtataaatt gctatgcttg gcacactgtg
     2941 gcgcctttac tggctcaagc gtgctaagac ttattgcaaa ccgtgcatgg ctacatattg
     3001 aagtgttggg ctgtgtattg acttatcccc ccacatcaag caacatctat cgctaacaga
     3061 acgctttcaa cacacctaaa cgcccccgac aattgtattt gcactggcgc atggcgagaa
     3121 gctcgacctc tccattagcg acgaagtaag gctaagctgc tgcttacatg cttttaggcc
     3181 aaacgtgctt ggcacgattt gactgttgcg acgcgtgttt aaacattggt ttctcgcgct
     3241 ggctgttctc catgggcatt atccccagta gttcataaac accaaaataa atagacgttc
     3301 aaatgtcttt ggggcattgc cattcgttgg gtgaagtgta tttcgcacct gaacttgcca
     3361 gacgccatcc ctacgaaggg cgcgagaacc ttctctcatc gactaactcc ttcttatcgt
     3421 gcgttatatg cgcgtgggag catattttat tggttttaat agggagggac gcaagagcgt
     3481 ccctcttctt gttttatatc ttatgtggct tttaacccaa gtttttcttt gttctatctg
     3541 ggttataact gtgatagctg ttttgtatgg cgatgttaaa cttaatggca atctaatggg
     3601 gatttggttt ctgtgctggt tttgttttca tggccatcaa gaaagcgatg gggcaaatca
     3661 tggattattc tctaatggtg gggcgtgtat ctgctagttt ttaactgggt gtttgtatag
     3721 tagacttgta gagaacgatg ccgttaatat ggagctattt ctcttttttc gctgtattgt
     3781 gtatcgagat ttgttttcaa tggtgtaaaa tatttgtact aaattttaac attgtgagtg
     3841 ccttgtgtga gaatttttcg ggtgcggggc ggaaatttgg gcgtatttcg aaagtttgta
     3901 atgatttgaa tttcagctgt ttgtgtggtt ttagctgaaa aaacgccatt atttgcttgt
     3961 atatacaagt gcttagcata tttaatcgcc agtgtaatgg ctgcgaagct gatatttgtt
     4021 gcaagtttac attttgttag ttaattgtct ttcgagtgct gtttttcgtg cagttatttt
     4081 cttggttctt cttctgagtg gtgtattttg tgacattctg tcttgtgttt tgcagcattt
     4141 agctctgcgt tttgctgcat ttaaccttgc gttttgtagg agatagcctt gcgttttgtt
     4201 gcagttaaca gtgcgttttg ctgcattttg cagtgctaat tgtacctaaa ataagcgtat
     4261 tttttttgca aagttggctg cgaatttagc gcaatttttc ttgaaataga aggctaaagt
     4321 catagtaaat tgcaaataat ggggcgaaaa atggtggcgg tggtttcctg ttttaatcaa
     4381 aaaatggtgg tttagatggt ttttagcggt catttttctc tagaagggtg ggtttggaag
     4441 gatgtgtttt gtaaaataaa cctaataaat taacagttgg tatataatgg aaaattagtg
     4501 gttagcgtgg ttaagcgttt gtgtactgtt gagcgcattg cctttgttgt agaagaataa
     4561 gtagggcaat acaccaaaag catgagcgat gcaagagacc aacaagcaaa cgaaagagag
     4621 aatagacgcc atgaaaacaa tatacaacat gtgataagtg gcctaactta gagattgggg
     4681 ataatgcttt agccgaaata aggtggcaaa ggcattgcta atggcaaaag agtgagggaa
     4741 agaaaaccac tagcgtgtgg ttaaagataa gccgaataac agaaaaagac tattcggcat
     4801 gggtgtttat gggtttactt tctggttcat ggcctttact ttctcgttga tataggcggc
     4861 aaattgggca ctgccaagca cgtcgatgtc gtggtaaaga cccagcacga aacgcccgat
     4921 acccaaataa ctggccactt cggaggcgaa aatccagtgg ttgggtgtgt tggctggagt
     4981 gatataagct tcggcagcgg ggtattcttc caataagatg ctgtgtgcca acctacccag
     5041 ttttagttca acaggcaggc gttcttcgcc gctaaacata aataagtcgg tgaagataga
     5101 tttatgactc tgttcgttga gccattccac atcggtcatt tccaccgaag cagcgcgcga
     5161 ggttttgaac gttttgttgg tatggctgtt aatttcgaag catctaatat ccatttcggc
     5221 attaagaaac aagaatggtt ccaccattct gtcgctcacc gttctactat gaggcgacga
     5281 atagtttttg agtataacca cacggcgcag ctgtatggcc tcgcgcagca cggcagcgtt
     5341 gctttcagcc tgtcgtcttt gtcccacatc ggtgagcaat tccaggttga agaaacgttc
     5401 cagttttgat tgtatgcttt tggagaggta gtcggtgtgt ggcaatctgt cgagcagtcg
     5461 gtacaccatc atggcctctt cttcggtgaa tgcgatgttt tcgtgcagtc gtttaaagaa
     5521 gggcgaatgc ctgtcaagtc tatattttgt gttggttttt acgagtttaa acccgcaagc
     5581 acgcagattt tcgaggtcgt aataaagttg tcggcgtgtg atgtctagtc tatcggccag
     5641 catctgcaca gaatagtctt tgttttcggt taataaaagc aggagttcca gttctcgtct
     5701 aaggttgttc attgggactt tatgttaata aatgagcctc acccccagcc cctctccaag
     5761 gggagagggg agtgatatgc tttgttttta ttgggtaatt aaccgtattg gtgctgttgg
     5821 aacagatagg ggctaatagg gttgatgaaa tagataggga ctaataggca agtggggtga
     5881 gagggactat acattaattg ccattactat ccaaatcacg ataaagcagc ctggctaatc
     5941 actcccctct ccccttggag aggggctggg ggtgaggctt tttttatttc ttcaccacct
     6001 tcatcatttc ttccacggcc ttaaccagtt gtcggtcgta accattgata tagtcttcgg
     6061 gtgagttata cacttcgatg tcggggttga gctgcgtgtt ttcgccgtag ttaccgcgca
     6121 agtcgcgaca tcccacttgt ggaataccaa agacgatgga ggggtcgagc atgttttccc
     6181 accaaacggc ggtcattgta ccagccacag gtgtaccgat gagtttgccg atgcccagtt
     6241 ctttgtacac ccaggggaat ccatgtccgt tgctgtagtc gtcttcgcat atcattacgc
     6301 acgagggttt gttccatttg ttaaaggggt cgctgcccac atagcgtcca ttaggcacaa
     6361 actgctggta ttctttacca ttaagcagcg tgcaaaggtc gtcgtgtagc catccgccgc
     6421 cgttgtgtct ttcgtcaaca ataacggcgt ctctatttct attggtatcg ctcagcagtt
     6481 cgaggtacac ttgtcggtag ctagggctgt tcatagcctt tacatgcacg tatgcaagtc
     6541 ggccacccga gaggctgtca accaagtgtc tgttgcggtc tacccatcgt ttgtagagca
     6601 gttcctgttg ttcgctagcc gatacgggtc ggattaccac gtcgaagcgt ttttttgttt
     6661 tagggtcgaa taccgacacg cgcaccggtt taccagcttt gccatcgagc agtgggaaat
     6721 agtcttgtcc ttgcacgatg ctgtctccgt cgattttttc gatgatgcaa cctgcagtaa
     6781 ccttagtgtt gcgcacagca aaaggtccgc gtttaatcac ttcttgcacg cgcagtccgt
     6841 tgccagtgta gtcgttatcg aagaaaagtc ctagatgcgc tgtttgcaag cgtggcgcag
     6901 tgccccagta gcgtgcgcca gtgtgcgagg cgttaagttc gcccagcatt tcgctaagca
     6961 tttcgctaaa gtcgaagttg ttgttgatgt aggggaggaa tttttcgtac acctttttat
     7021 agttggccca gtctacgccg tgtagtgtag gttcgtagaa tttatccttc acctgttgcc
     7081 aaacatggtt aaacatgtat tgtctttcgg cataaggttt gaagttgaag cgagcttcga
     7141 actcaatatt tttgctagaa ttgctgctta ggtcgatttt cttgatggcg ttgtagtcgc
     7201 agaggtagag gtggcggaag tctttatcag gcaaaaactc gccactaccc acatttttca
     7261 ttacaataga ggtgcgatct tcgctaattt gtcgtttcca caagtcgtat ccgccttcga
     7321 acgacgcttg ataatagagt gtatctccgc cgttgcttag cacgtaatcg cccaagtgcg
     7381 aagagtggtc cgtgagccga ataacgcggt cgcgacaatt ttcgaggtcg aaaaccagcc
     7441 ctttaggttc gtctttcttt ttcttattag ccgaaccaac ttttattttg tcttcctctt
     7501 tatccttttt atcttttttg tccttttgtt gttcttgttc ttcgttttta gccagttcgc
     7561 gttcttcctt gttgcgtctg aacttttcgt aagcatcgag gtcgaagaac atgatataga
     7621 catcgcgttc tgcaccccat gagccatgac tgcgatatcc agctcggtcg ctactgaaga
     7681 tcatggcttt tccgccaagc acccaacgag gtccgccgtc gctgtatccg ctttgtgtga
     7741 ggttatgaat ttcgcccttt ccatcggcct taaccagtgc gatgtcgggg ttgttccatc
     7801 cgccaatgcc gatataagaa gcgagtagcc aacggctatc ggggctccaa gtgaagccga
     7861 tatcgccatc cgagtacgaa tacacaaact ttccgtccat cacagtgcgt acttccttgc
     7921 tcttaatgtc gagaacgcgc agtgtagagc ggtcttcgta gaaggcaata cacttgccat
     7981 cggggctaaa gcgcggttgt tgcgatgtgc gattgctttt taccagttgt tcttcttcaa
     8041 gctgagtggc ataggcaaag ctcttttcct tgtctaattt cagttttgtg cgatagattt
     8101 gccacagtcc gttgcgttcc gaagcataaa caatgcttcg tccgtcgggt gcaaattgaa
     8161 tttcgcgttc ttgttcgggg gtgtcggtaa tctgctttgt ggtgcggtag tccatcgaag
     8221 ttacgtacac atcgccgtgc aaaacgaagg ccaactcctt gccatcaggc gagagagaaa
     8281 tctctgttgc gcccgtgaag agcgtctgtc ggtcaaggtc tttatccgtt ttgtcggtca
     8341 cgatgttcac ctttagcttt tgaggttgag caccttgctt gagtgtataa atctccccgt
     8401 cgtatccata gcacaatgtg ccgtcggtag cagcggtaag aaagcgcacg gggttggtgg
     8461 tatgtcgggt aagttgttgt ttatcagtac cgtcaatatt tcgtttgtac acgttgaatg
     8521 tgccatcttc ttcgctcaga taataaaacg agtcgccttg agcggcccaa acaggcgtgc
     8581 ggtcttcgcc attaaagttg gtgagtttgg tgtatttgcc tgctcttctc aaccaaatat
     8641 ctcgtgtgat gggcgagcgg tggtgctttc tcagcgggtc ttcgtagcct ttttggtcgt
     8701 gataaagcaa gtcgccatta ggtcggatgc tgatatccat catgggcaaa gccgagaaaa
     8761 ggcgagggcg cgaggcgtta gtgctcacct cgtagacctg aggaagcgag ccattagcaa
     8821 acaaaatgct ctgagcagtg ggcatgatgc tgcttacata gagcactgtg ttgttgtctt
     8881 taaaggcgat gggcgtttcg gttccgctgt tggtggtgag tctacgcggt gcgccgcctt
     8941 ccctgttcat tacatacacg tccatacttc cctcgcgatt agagcagaag gccagctgtt
     9001 tgctgtctgg gctccacacg ggataggagt cgtgggcgga gttagttgtt agttgcctag
     9061 cgttaccgcc cgtagcgggt acggtgtaga tgtcgccttt gtaggcaaaa gccacggtag
     9121 agccatcggg cgaaatagca caatggcgca accacaatgg attttcttgt gccgatgccg
     9181 tagtagctaa ggcaagggcc atgatagtga gggtagtttt catcattata taatggaatg
     9241 tctttattgt taacgtgatt gttaggaggt tattggcggg gcatgagaga taaaagcata
     9301 tcagagcgag cccccaacag gtaaaaattc ttttttcttg gctgcaaatt tattgaatat
     9361 tcgcgagacg gcaaaagggt tagtagagaa aaatttgcaa ccttgaagca gaatagataa
     9421 gcgatgggat agagaagtaa gaatgttcag cgtaaaaatt atgaacaagg gaaaggtgga
     9481 ttgctgttta cataccgcca ttaagagtgg atttgctgtg tcaagatgtg ttgtgagggc
     9541 ggagtatttg tgtcatcttg tctgaaaaag ggtgcttctt gttgtcgttt gttaataata
     9601 gagcggtgag aagtattctc gcggaagata tatataggtg taataaagcg tgaaaaatac
     9661 tttggaaaat cactaaaata tagtattttt gcagcgtgtt acatatgtgg catacctaaa
     9721 tcaaggtatt gcagacaagg ttaagtttgt tttttgtgcc gttttggcca cgacttcagt
     9781 gggagtaggg tgtaagattg cgcaagaaac acgctgtaaa cacttcgggg tataaagaaa
     9841 atgcccgtct gcaatcacga tgcaatgaaa gtacgcaatg gcttgtgcgc aaaataggta
     9901 gcttttgtgg ccgaggatac tgcaggaaca tgcaattggg caaatcaaca ataatgggaa
     9961 aataatacaa acataattaa ataattaaat tcaatcattt atgtggttaa tcaattcttc
    10021 tatcggtaga aaggttgtca tgtctgtaac cggcgtggcg ctcgttctgt tcttgacatt
    10081 ccatatgtca atgaacatcg ttgcgctgtt ttcggaaaag ggatacaaca tgatctgcga
    10141 gtttttgggt gccaactggt atgccgtagt tgccacgctt ggtcttggag ccttgactgt
    10201 ggcgcacatt gtgtatgcct ttatcctcac ggcacaaaac cgtagagccc gcggaaacga
    10261 gcgttatgct gttactagca ggcacgagaa ggtggaatgg gcatcgcaaa acatgcttgt
    10321 tctgggtatt atcattgctc tgggcttggt gttgcacctt tacaatttct ggtacaacat
    10381 gatgtttgca gaacttattg gtgtggaaat gaagttccat ccagccgatg ggtttgctta
    10441 catcagggaa acattctcta atcccgttta tgtagtgctc tacattgtgt ggtttgtggc
    10501 catttggttc cacctttcgc atggcttttg gagtgctatg caaagccttg gcgttagtgg
    10561 caaggtgtgg tttaaccgtt ggaaagccat cggtttggct tataccaccc tgcttatgtt
    10621 gggcttcctc attgtagtgt tggccttcgc tttcggttgt gcgcctagct tgtgcgcctg
    10681 ctgcgcttaa tcatgatacc aataaaaaga taaaattatg gctattaaaa tagattcgag
    10741 aatacccgaa ggacccgttg cagagaaatg gaccaactat aaggctcatc agcgactggt
    10801 taaccccaag aacaaactga aactcgatgt tatcgttgtg ggaactggtc ttgctggtgc
    10861 cagcgcagcc gcttcgcttg gcgaaatggg tttcaatgtg ctgaacttct gcatacaaga
    10921 ctcaccccgt agagcacact ctatcgctgc tcagggtggt atcaatgccg ccaaaaacta
    10981 tcaaaacgat ggcgactcgg tgtatcgcct tttctatgac accgtaaaag gtggcgacta
    11041 tcgtgcgcgt gaagctaacg tttaccgctt ggccgaggtt agtaacagca ttatcgacca
    11101 gtgtgtggct caaggtgtgc ccttcgcacg tgaatatggc ggtatgttgg ccaatcgctc
    11161 gttcggtggt gcacaggtaa gccgtacgtt ctacgccaaa ggtcaaactg gtcagcagct
    11221 tttgctgggc gcttactctg ctcttagctg ccaggttaag gcgggaaagg tgaaacttta
    11281 cacccgttat gaaatggaag acgtggtaat tgttgacgac cgtgcacgtg gtatcatcgc
    11341 aaagaacctc gttacgggta agctagagcg cttctcggcc aacgcagtgg ttattgcaac
    11401 tggcggatat ggcaatgctt acttcctttc taccaacgct atggggtgta actgtacggc
    11461 tgccattcag tgttatcgta aaggcgcata ctttgcaaac ccctcttatg tgcaaattca
    11521 ccccacttgt attcccgttc acggcgacaa gcagtctaaa cttacactga tgtctgagtc
    11581 gttgcgtaac gacggtcgta tctgggtgcc caagaagatt gaagatgcta aggcattgca
    11641 ggccggtcag aagcgtggtt cggatattcc cgaagaagat cgcgactatt atttggagcg
    11701 tcgttatccc gctttcggta acttggttcc tcgcgacgtg gcttcgcgtg cagccaaaga
    11761 gcgttgcgac aaaggttttg gcgtaaacaa tacgggtctt gcagtgttcc tcgacttctc
    11821 tgaaagtatc gaacgcctag gcatcgacgc cattcaacag cgctatggca acctcttcga
    11881 tatgtacgaa gagattaccg acgttaatcc tggcgagtta gccaacgaga ttaacggcgt
    11941 gaaatattac aaccccatga tgatttaccc cgccatccac tatacgatgg gcggtatttg
    12001 ggttgactac gaactgatga cctctatcaa aggcctcttc gctattggcg aatgcaactt
    12061 ctctgaccac ggagctaacc gcttgggcgc gtcggcactg atgcaaggtc ttgcagatgg
    12121 ctactttgtt ctgccttaca ccatccaaaa ctatttggcc gaccaagcta tttggccacg
    12181 tctttctacc gacctgcccg aatttgccga ggccgaaaag ggtgttcaag acgagataga
    12241 cagactgatg ggtatccaag gacaacgctc ggtagactct attcataagg aattgggcca
    12301 catcatgtgg gaacacgtgg gcatgggtcg cactgccgaa ggtcttcgcg agggtattaa
    12361 gaagatgaaa gaactgcgta aggagtttga tactaacctc ttcatccctg gttcgaagga
    12421 aggtttgaac gtagaacttg ataaagcaat ccacttgcgc gactttatta tcatgggcga
    12481 actcgaagct tacgatgcac tttcgcgtaa cgaaagctgc ggtggacact tccgtgagga
    12541 ataccaaaca gaagaaggcg aggccaaacg tgatgatgaa aacttcttct acgtaggttg
    12601 ctggaagtat caaggtaacg ataccaccga gcccgaactc attaaagagc ctctggagta
    12661 cgaagcgata aaggttcaaa cacgtaacta taagcaataa ttaagttgac gagttgacaa
    12721 gttgacgaat taacacgcca acttaaacaa aactaaatca catggacaaa aatataagtt
    12781 tcacactcaa agtgtggcgt cagaatggac ccactgccaa gggacatttt gatacattcg
    12841 aaatgaagga tatacctggc gacacatcgt tcctagagat gcttgacatc cttaacgaac
    12901 aactaattga ggctcgtcaa gaaccattcg tgttcgatca cgattgtcga gaaggcatct
    12961 gcggtatgtg ttcgctttac attaacggac atccccacgg ccccgcaaca ggtgctacca
    13021 cctgtcagct gtacatgcgc cgcttcaaag atggcgatgt tatcaccgtt gaaccatggc
    13081 gttcggctgc attccctgtt attaaggact gtatggtaga ccgtggcgcg tttgataaga
    13141 ttatccaagc tggtggttat accaccgttc gtaccggaca accacaagat gccaatgcta
    13201 tccttatccc taaggaagac gccgacgagg caatggactg cgccacatgc atcggttgcg
    13261 gcgcttgcgt tgcagcttgc aagaatggtt cggctatgct cttcgttagt tcgaaggtta
    13321 gtcagctcgc actgctgcct caaggacgcc ccgaagcagc taaacgcgct aaagcgatgg
    13381 tgatgacaat ggaagaactg ggctttggta actgcaccaa tactcgtgct tgcgaggccg
    13441 aatgccccaa aaacgagtct atcgccaaca tcgcacgcct taaccgcgag tttatttcgg
    13501 ctaagttggc cgactaaaca ccgaggctta acgccttacg cctggctcga acacattgct
    13561 tgttggcttg tgtcttgcca cgagcgcacc tatgcgtgct aatatcatta tgtgagaacg
    13621 ttctgtggct ttccatgggg cgttctcaca ttgcgtttta taccatcact tttcctcaat
    13681 aatttctttg ttactgacaa agttttcata cctttgcacc aaaaagatga gaattgcaac
    13741 tgtgatactc gactttgatg ggacgcttgg cgactcgcgc cgtatcattg tcgacacatt
    13801 aagagagaca ctcaggcaac acaacttgcc tgttagcacc gaagaacaat gcgcagccac
    13861 catcggactg cctcttaaag aggcttttgt gatgctggca aacgtagatg aagacacagc
    13921 aatgaagtgt gtgaacacct atcgtagcat tttcgatgta aacaacgtta ctggtgcggt
    13981 gaaacctttt gctaatgtgg tggataccat caaacaaatg tatgccgcag gactaacact
    14041 caccattgct agcagtcgtg gacgcgactc gcttcctcat cttgcgcaaa gcatcggcat
    14101 tggccagtac atcagttaca tcgttagtgc cgaggatgtt gttaacgcta aaccacatcc
    14161 cgagcctgta ctcaaaacct tagaacatct cgatgccaaa ccccaagaaa cgctcgtggt
    14221 gggcgatatg gctttcgaca tagagatggg acggcgtgcc aacaccttta cttgtggtgt
    14281 tagttatggc aatggctcgg tgaacgaatt ggaagaggcc ggcgccaatt gggtgatcga
    14341 cgactttgcc cagttgctta acattgtgtt ctagtgcgct gcacccaaac aaaggcttac
    14401 aaaccaagcc aaaccatcgc atcaaacaca tcgtggctta gccctaagtc tggccattgt
    14461 cgatgcattg agccgaaaca atcctctcga acactacaaa tgtaggcgct ataaaatccc
    14521 tatgtcacca agaaatatag caaatcacac cgcgctcacc actaattaat aaacgataaa
    14581 cccataaaag caatagctat gcagcccatt cttaatcatt ttaccgacaa cgatgcttat
    14641 accttcagtt gccagtatta cgttttgcag acctatcccc gtgccgaagt tgaatatacc
    14701 ttcttcgacc gtaaccatac tgcctaccca gaaggctttg ccgacaaggt gagagaacaa
    14761 attaacttga tgcagaacgt gcgaataacc gacgaagaga ttgcgtttat gcagcaacgc
    14821 atgtattatc tgccccaatg gtacttcact ttcttgcgcg gatacaagtt taatcccagc
    14881 gaagtgcaca tcgaacaaag tgccgaagga caactggcca tctccattcg tggtaaatgg
    14941 tattccacta ttatgtggga aatgcccgta ctctctatta tttctgaact gatgcaccaa
    15001 catcgcggcg acatcgaacg ctacgatgag gcactagagt acgaacgtgc agccgaaaaa
    15061 gctagacaaa tactgcgtgg tggactgatc ttgggcgata tgggcacgcg tcgccgactc
    15121 tcttttgcac accacgacaa tgtgttgcgt gcaatgaaag ccaccgccga ggcgggtggc
    15181 gaaaccgtag acggcgtgtt ccaaccctgg aagggtcgca ttgtgggcac cagcaacgtg
    15241 tatttggcca tgaaatataa cttagtgccc atgggaacga tgagccatca gattatagaa
    15301 tttgaagaaa acgttagcgg catcttcgaa tgcaacttta atgtgatgcg taagttcagc
    15361 gatgtttacg atggcgacaa tggcatttat ctttacgact gctttggcga taaggttttc
    15421 ttcaataatc tctctaaacg tatggcgctt atgtttacag gtttgcgcgt tgatagtggt
    15481 gttgaggaag aacaaaccga gaaaattatc gagaaataca aacagctggg tattaatcct
    15541 gccaccaaaa aggtgatttt tagtaacggc ctgaacatcg aacgcgcttt ggaaattcat
    15601 cgttttgttg acggaagagt gcaagatagc tacggcatgg gcacattcct cacgtgcgat
    15661 gtggtgggat gcaaacctat gaacatcgtg gtgaaactca ctaagtgccg tatcaccgaa
    15721 aaacgcgagt ggcacgactg cgttaaactc tcgtgcgata aaggtaaaac actgggtaat
    15781 cccgagaaat gtgcctacct cctaaagcaa ataggatagg ccaaagggat gtgaaagcaa
    15841 aagattagcg aacgaagact gctcgtttca tagccaacgg tcttcgttcg cccatcatcg
    15901 acaattaatt tgctcaaact cagttggcag gtggacttta attttaaccc ttcatggtga
    15961 aagtgcttta ggtagggatg agcttagagg ccaaaaccag atatgtatga tatatataac
    16021 aaacataatt aacttaatta catgacgaaa caattatttt ttctagtcgc gttagcgctg
    16081 cttttttctt gctcaagtag ttcggataaa acctacgaac caaccattgc atcagccatc
    16141 attaacagcg tgtatctgtc tgttcaagac gaaaagggtg aagtgataga ccaagatcag
    16201 ctgttgaaag acgcaagggt gcaggtgcgc ggatgcgaaa gcagaaagcc actacacatc
    16261 actagcacag cgattggcga tgttaagttt ttgagtttct cgcccgattt accccaccgc
    16321 gaagtaatgc gtttttggga tagtaaagaa ggcaaacgcg gcactggcta ttcggatgca
    16381 gaactcacaa ttgatggcgt aacaatgaaa cttcgatttc attatgacta tgccgaagca
    16441 ttaaatgccg aaaaactgtt gggtggttca agcattattc taaaagccgt tgagtgtaat
    16501 ggcaagaaga taagtgtaca agaccataca caattcttta tcatcacgat gaagaaaacg
    16561 gccggcggtt acgaactacg cccctaaccc ctacctcgca gcaaggccat attatgcact
    16621 tgtctgcaaa ttgctaagaa atagaggcta acgatgctag gcgcatcgtt gcttactacg
    16681 ctaactttta accccaattg cttattagag cctaaacaga tgttgtttta tagtagagca
    16741 gattgcccgt ctttgtaacg caggcgtagc gggctacgtc aagttgcaaa ggcagacaag
    16801 atgccgacaa gaaaataaaa gctgttagga aacaacacc
//
