LOCUS       c00043_NZ_JACH..       12207 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_JACHZF010000043.1 Halomonas campaniensis strain 5AG Ga0075189_43,
            whole genome shotgun sequence.
ACCESSION   c00043_NZ_JACH..
VERSION     c00043_NZ_JACH..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 01:37:07
            Original ID  :: NZ_JACHZF010000043.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12207
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12207
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[6185:10583]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      6186..10583
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..12207
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12207
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(96..917)
                     /locus_tag="ctg43_1"
                     /transl_table=11
                     /translation="MRVFTPTARLAALLLASTLLVGCASSGSTEEEDEFAGVAERELYE
                     EARGSLERRNFTAAITRLEALDTRFPFGNHAEQAQLELIYAYYETSDWEAARAAASRFI
                     RLHPSHPQADYALYMRGLSSWQAGRFSLERLKLIDISKRDLGASRDAYTDFSELVRLYP
                     NSEYAPDAQQRIVYLRNLMARHELHVADYYLRRGAYLAAVERGRWVIENYPETEATRDA
                     LAVMVEGYLGLEMRDRAREVLDVLIENAPRHDQLRGRTFEPRHVRAQSLSA"
     CDS             1059..2018
                     /locus_tag="ctg43_2"
                     /transl_table=11
                     /translation="MSQTLEAQQRVPDAMAGLRLDQAAAELFADHSRERLKAWIKSGEL
                     TVDGNPARPKDKVYGGEQLQLAAEVEDDTRFEPQEIPLAVVHEDDEVLVIDKPAGLVVH
                     PAAGNPDGTLLNALLHHCPSLAGVPRAGIVHRLDKDTTGLMVVAKTLAAQTALVEQLQA
                     RTVSREYDAVCVGAMTAGGTLEAPIGRHPKDRKRQAVTASGKPAVTHYRVVERFRAHTH
                     VRCRLETGRTHQIRVHLAHLRYPLVGDPVYGGRLKLPPGAAEPLKEILREFPRQALHAR
                     RLAFVHPGSGERVTFRSPLPDDMLMLIDYLREDHATMR"
     CDS             2043..2798
                     /locus_tag="ctg43_3"
                     /transl_table=11
                     /translation="MSDAPDLRPTLILPDWPAPTSVGAFVTTRETGPSQGDFACFNPAE
                     HVGDNADHVALCRRLLQKQVDDERPLLWLDQVHGARVQQAYDAHAPEADAAVAFDRDYA
                     CVVLTADCLPVFFSDRRGTRVAVAHAGWRGLAGGVLEATVAALGVPAEEQLAWLGPAIS
                     NAQFEVGPEVQQAFVGVHPEAADAFDPSPYRLGHYMADLYRLARLRLERLGVSHISGGH
                     FCTACEPRFYSHRRDDGRTGRMASVIWLR"
     CDS             3111..5693
                     /locus_tag="ctg43_4"
                     /transl_table=11
                     /translation="MRFDKFTAKLQNAVADAQSLAVGRGHNQLEPGHLLLALLEATDTG
                     VKALVQKAGGDAARLREGLTGHLDDLPKVAHFDGEVQPSRDLIKLFNLTDREAQKRGDQ
                     YIASELVLLAALEMGHAVTRLLTQAGVTRKSLVAAVDSVRGGERVDDPNAEDQREALEK
                     YTLDLNERAASGKIDPVIGRDDEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQR
                     IVDGEVPEGLKDKRVLSLDMGALLAGAKFRGEFEERLKSVLKELAQEEGRVILFIDELH
                     TMVGAGKAEGAMDAGNMLKPALARGELHCVGATTLDEYRKYIEKDAALERRFQKVLVDE
                     PSEEDTVAILRGLKERYEVHHGVDITDGAIIAAAKLSTRYITDRQLPDKAIDLIDEASS
                     RIRMELDSKPEEMDRLDRRLIQLKMEREHLRKESDEASRKRLETLEEQIGELEREYADL
                     DEIWKAEKASIQGAAQFKDELDRARVDLEQARRQGDLARMSEIQYGVIPALEKKIAEAG
                     EGEADTSRHQLLRSNVTEEEIAEVVSRWTGIPVSKMLEGERDKLLRMEEALHERVIGQD
                     EAVTAVANAVRRSRAGLADPNRPNGSFLFLGPTGVGKTELCKSLANFLFDTEEAMVRID
                     MSEFMEKHSVARLIGAPPGYVGYEEGGYLTEAVRRKPYSVLLLDEVEKAHADVFNILLQ
                     VLEDGRLTDGQGRTVDFRNTVIVMTSNMGSDIIQRMGGDDSDYAQMKEMVMAVVGDHFR
                     PELINRIDEVVVFHALGQAQIQAIAEIQLDRLRARLAEHDLSLEVSEAALGLLAEAGFD
                     PVFGARPLKRAIQARIENPLAQDLLAGKFSPGDVIHVEAEGDQLVFQS"
     CDS             6186..7910
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_5"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.2e-47, bitscore:
                     150.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VELLSGADMIARFLQDEGVEYIYGYPGGAALHIYDALFRQDKVKH
                     ILVRHEQAATHAADGYARAAGKPGVVLVTSGPGATNAVTGIATAYMDSIPMVVLCGQVM
                     SHLIGDDAFQETDIIGVTRPIVKHSFSIKHPTEIPEVLKKAFYLAATGRPGPVVVDIPK
                     DMTAPTERYEYVYPKKVKMRSYNPVSRGHSGQIKKAVEMMLKAKRPVFYTGGGVVTGRA
                     SEGLTDLVKRLGYPVTTTLMGIGSYPQSDRQCLGWLGMHGSYESNMAMHHADLIIAIGA
                     RFDDRVTNNTSKFCPTAKIIHVDIDPSSVSKTVRADVPIVGPAGSVISEMISLVQGKEV
                     AHPEALAEWWQKIDGWREERAGRLYEPSKPGEAIKPQEVIEALCRVTRGEAYVTTDVGQ
                     HQMFAAQYYKFDKPNRFITSGGLGTMGFGFPAAMGIKQNFPDEQVICVTGEGSFQMMMQ
                     ELSTCKQFGGGVKIVNLNNASLGMVRQWQDLNYKSRHAHSYMESLPDFQKLIESYGFTA
                     MKVETLDQLEPALERTFADKHELVFLDVAVDPHEHVYPMQVPLGAMRDMLLSKTERT"
     CDS             7910..8401
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_6"
                     /sec_met_domain="ALS_ss_C (E-value: 1.4e-31, bitscore:
                     97.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRHIISILMENEPGALSRVVGLFSQRNFNIETLNVAPTEDETLSR
                     LTVTTVGDDRVIEQITKHLNKLIDVVKLVDLTEGNHIERELMLVKVKALGAARDEVKRT
                     VDIFRAQIVDVTPSLYTVQITGDAGKLDAFLQAMAPVGILEVARTGVSGIARGDKVLSL
                     "
     CDS             complement(8505..9392)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     65.6; E-value: 9.4e-21)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg43_7"
                     /sec_met_domain="LysR_substrate (E-value: 1.1e-41,
                     bitscore: 131.7, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 1.4e-21, bitscore: 65.6,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLRPLKHFLALAETLHFGRASEACHVSPSTLSRSIRQLEETLGV
                     ALFERDNRHVALTRQGVTFQRYARETLEQWEQLRLSLMSEARRLTGEISVYCSVTASYS
                     FLYELLSEFRAHHPGIELKLHTGDPAEAMSRVLAGDEDMAITPRPRQTPEALAFKSLTR
                     SPLVFIAPHDRHEWIPATPETPSAEQWRQVPMVLSEAGLSREFANTWFRALGITPRIYA
                     QVAGHEAIVSMVGLGFGVGVVPKIVLDNSPLVERVRVLPVKPELPHYDVGLCVLERRLR
                     SPLIRALWDEVVER"
     CDS             9567..10583
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_8"
                     /sec_met_domain="IlvN (E-value: 1.7e-79, bitscore: 254.4,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 3.1e-64, bitscore: 204.9,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHVYYDKDCDLSLIQGKKVTIVGYGSQGHAHANNLKESGVDVTVA
                     LREGSSSAAKAEAAGLKVASVPEACKTADVVMILAPDENQKAIYENEVEPNLKQGATLA
                     FAHGFNIHYNQIEPRKDLDVIMIAPKAPGHTVRSEFVKGGGIPDLIAIHQDASGSAKEL
                     ALSYAAGVGGGRSGIIETTFKDETETDLFGEQAVLCGGAVELVKAGFETLTEAGYAPEM
                     AYFECLHELKLIVDLMYEGGIANMNYSISNNAEYGEYVTGTEVINEQSREAMRNALKRI
                     QTGEYAKMFIQEGNSNYPSMTARRRLNAEHDIEIVGAKLRGMMPWIAANQLVDKSKN"
     CDS             10748..11629
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CDP-OH_P_transf"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg43_9"
                     /sec_met_domain="CDP-OH_P_transf (E-value: 1.7e-16,
                     bitscore: 50.2, seeds: 996, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQDPRNTEHDLSQPGNETPGEAAADRAPPAEEDLAAAFVRETEV
                     IEEAVENGQKVRRKGIYLLPNLFTTSALFAGFFAVVAGINGDFTAAAVAIFIAMVLDGL
                     DGRVARMTNTQSAFGAEYDSLADMLSFGVAPALVAFTWILQDIGKTGWVVAFLYVACAA
                     LRLARFNVQIGSVDKKWFIGLPSPSAAALVAASVWTFHTLDAEAFGFKLLMLFIVGAAG
                     VLMVSNIRYHSFKEIDLKGPVPFVVLLAIVLGFVVISVQPSVMLLLLFGAYVASGPVMA
                     AMRKLKHAPPTA"
ORIGIN
        1 ggcgctcggc gctcggcgct cggcgctcgg cgctcggcgc tcggcgctcg gcgctcggcg
       61 ctcggcgctc ggcgctcggc gctcggcgct cggcgtcagg ccgacagcga ctgggcgcgc
      121 acgtgcctgg gctcgaaggt gcggccgcgc agctggtcgt ggcgcggggc gttctcgatc
      181 agcacgtcga gcacctcccg ggcgcggtcg cgcatctcca ggcccaggta gccctccacc
      241 atcaccgcca gggcgtcgcg ggtcgcctcg gtctccgggt agttctcgat cacccagcgg
      301 ccgcgttcca cggcggccag gtaggccccg cggcgcaggt agtagtcggc cacgtggagc
      361 tcatggcggg ccatcaggtt gcgcagatag acgatgcgct gctgggcgtc gggggcatac
      421 tcgctgttgg gatagagccg caccagctcg ctgaagtcgg tgtaggcgtc ccgcgaggcg
      481 cccaggtcac gcttggatat gtcgatcagc ttcaggcgct cgaggctgaa gcggcccgcc
      541 tgccaggagg acaggccacg catgtagagc gcgtagtctg cctggggatg gctcgggtgc
      601 agccggatga agcggcttgc ggcggcgcgg gcggcctccc agtcgctggt ctcgtagtag
      661 gcgtagatca gctccagctg cgcctgctcg gcgtggttgc cgaacgggaa gcgggtgtcc
      721 agggcctcga gccgcgtgat ggcggcggtg aagttgcgcc gctccaggga gcctcgcgcc
      781 tcctcgtaga gctcgcgctc ggcaacgccg gcgaactcgt cctcttcctc ggtggagccg
      841 ctgctggcgc agcccaccag cagggtggag gccagcagca gggccgcgag acgggcagtg
      901 ggggtgaaaa cgcgcatcgt gatcctcgtg gcaaacaacg cggattggcc gtgttagaat
      961 cgacctgaaa cccgctcact ataaagcact gcgtggcaaa acgcagtggt tcggcggcat
     1021 cccgaccacg acacctgcat acgggctccc tctcgctcat gtcccagacc ctggaagcac
     1081 agcaacgcgt tcccgacgcc atggccggcc tgcgcctgga ccaggccgcg gccgaactgt
     1141 tcgcggacca ctcgcgggag cgcctcaagg cctggatcaa gtcgggggag ctgaccgtcg
     1201 acggcaatcc cgccaggccg aaggacaagg tctatggcgg cgagcagctg cagctggccg
     1261 ccgaggtgga ggacgacacc cgcttcgagc cccaggagat ccccctggcg gtggtccacg
     1321 aggacgacga ggtgctggtg atcgacaagc cggccgggct ggtggtccat ccggcggcgg
     1381 gcaaccccga cggtaccctg ctcaatgcgc tgctgcacca ctgcccctcg cttgccggcg
     1441 tgccgcgggc gggcatcgtg caccgcctcg acaaggacac caccggcctg atggtggtgg
     1501 ccaagaccct ggccgcccag acggcgctgg tcgagcagct gcaggcgcgc acggtgtcgc
     1561 gggagtacga tgccgtgtgc gtgggggcga tgaccgctgg cggcaccctg gaggcgccca
     1621 tcggtcgcca ccccaaggac cgcaagcgcc aggcggtgac ggcctccggc aagccggcgg
     1681 tgacccacta ccgggtggtg gagcgcttcc gcgcccatac ccacgtgcgc tgccggctcg
     1741 agaccggccg tacccaccag atccgcgtgc acctggccca cctgcgctat cccctggtgg
     1801 gagacccggt ctacggcggg cggctgaagc tgccgcccgg cgccgccgag ccgctcaagg
     1861 agatcctgcg cgagttcccg cgccaggcgc tgcatgcccg ccgcctggcc ttcgtgcacc
     1921 ccggcagcgg cgagcgggtg accttccgct cgccgctgcc cgatgacatg ctgatgctga
     1981 tcgactacct gcgcgaagac cacgccacga tgcgctgata cccctgcgcc aaggaacccg
     2041 ccatgagcga cgcccctgac ctgcgcccga ccctgatcct gcccgactgg ccggccccca
     2101 cctcggtggg ggccttcgtg accacccgcg agacggggcc tagccagggg gacttcgcct
     2161 gcttcaatcc ggcggagcac gtgggcgaca acgccgacca cgtggcgctg tgccggcggc
     2221 tgctgcagaa gcaggtggac gacgaacgcc cgctgctgtg gctcgaccag gtccacggcg
     2281 cgcgggtgca gcaggcgtac gatgcccacg ccccggaggc cgacgccgcg gtggccttcg
     2341 accgcgatta cgcctgcgtg gtgctcaccg ccgactgcct gccggtgttc ttcagcgacc
     2401 gtcgcggcac ccgggtggcg gtggcccatg ccggctggcg cgggctggcc gggggggtgc
     2461 tggaagccac ggtggccgcc ctgggcgtgc cggcggagga gcagctggcc tggctgggcc
     2521 cggcgatctc caacgcccag ttcgaggtcg gccccgaggt gcagcaggcc ttcgtcggcg
     2581 tgcatcccga ggcggccgac gccttcgatc ccagccccta ccgcctgggc cactacatgg
     2641 cggacctcta tcgcctggcg cgcctgcgcc tggagcgcct gggggtgtcg cacatcagcg
     2701 gcggccactt ctgcaccgcc tgcgagccgc gcttctactc ccaccgccgt gacgacggcc
     2761 gtaccgggcg catggccagc gtgatctggc tgcgatagcg ccggtgtgcg ataccgggct
     2821 ctaggagggc ggcttcgccg cgcgactggc gtcgtcaggc gcccggcggt gtctccatgg
     2881 ctcgggtggc cacttccggg aggccttcgg cctccgttcg cccaatgaat tggcctccta
     2941 ccaattgcca ccttctgcct gcggggttga cccgcgtcaa cttgccacgc gcttcccctg
     3001 gcggtcgact tgaaagccgg cccgcctgac tccattgagt gtgtcaagac gaattgacag
     3061 ggccacgcgg tgcgtccgag cgcgccgcca ccccgatgga ggaaggtttc atgcgtttcg
     3121 acaagttcac cgccaagctg cagaacgccg tggccgacgc ccagtccctg gccgtgggcc
     3181 gcggccacaa ccagctggag cccgggcatc tgctgctggc gctgctggag gccaccgata
     3241 ccggcgtcaa ggcgctggtg cagaaggccg gcggcgacgc cgcgcggctg cgcgagggcc
     3301 tgacgggcca cctcgacgac ctgccgaagg tcgcccactt cgacggcgag gtgcagccct
     3361 cccgtgatct gatcaagctg ttcaacctca ccgaccgcga ggcccagaag cgcggcgacc
     3421 agtacatcgc cagcgaactg gtgctgctgg ccgcgctgga gatgggccat gcggtgaccc
     3481 ggctgctgac ccaggcgggg gtgacccgca agtcgctggt ggccgccgtc gacagcgtac
     3541 gcggcggcga gagggtcgac gaccccaacg ccgaggacca gcgcgaggca ctggagaagt
     3601 acaccctgga cctcaacgag cgggcggcca gcggcaagat cgacccggtg atcggccgcg
     3661 acgacgagat ccgccgcacc atccaggtgc tgcagcggcg caccaagaac aacccggtgc
     3721 tgatcggcga gcccggcgtg ggcaagaccg ccatcgtcga ggggctggcc cagcgcatcg
     3781 tcgacggcga ggtgccggag ggcctcaagg acaagcgcgt gctgtcgctg gacatgggag
     3841 cgctgctggc cggagccaag ttccgcggcg agttcgagga gcgcctcaag tcggtgctca
     3901 aggagctggc ccaggaagag ggccgggtga tcctgttcat cgacgagctg cacaccatgg
     3961 tcggcgccgg caaggccgag ggcgccatgg atgccggcaa catgctcaag cccgccctgg
     4021 cccgcggcga actgcactgc gtgggggcca ccaccctcga cgagtaccgc aagtacatcg
     4081 agaaggacgc ggccctggag cgccgcttcc agaaggtgct ggtggacgag ccctccgagg
     4141 aggacaccgt ggcgatcctg cgcggcctca aggagcgcta cgaggtgcac cacggcgtcg
     4201 acatcaccga cggggcgatc atcgccgcgg ccaagctctc gacccgctac atcaccgatc
     4261 gccagctgcc cgacaaggcc atcgacctga tcgacgaagc ctcctcgcgg atccgcatgg
     4321 agctcgactc caagcccgag gagatggatc gcctcgaccg ccggctgatc cagctgaaga
     4381 tggagcgcga gcacctcagg aaggagagcg acgaggcctc caggaagcgt ctcgagacgc
     4441 tcgaggagca gatcggcgag ctcgagcgcg agtatgccga cctcgacgag atctggaagg
     4501 ccgagaaggc cagcatccag ggcgcggccc agttcaagga cgagctcgac cgggcccgcg
     4561 tcgatctgga gcaggcgcgt cgccagggtg acctggcgcg gatgtccgag atccagtacg
     4621 gggtgatccc cgcgctcgag aagaagatcg ccgaggccgg ggaaggggag gccgatacct
     4681 ccaggcacca gctgctgcgc tccaatgtca ccgaggagga gatcgccgag gtggtgtcgc
     4741 gctggaccgg catcccggtc tccaagatgc tcgagggcga gcgcgacaag ctgctgcgca
     4801 tggaggaggc gctccacgag cgggtgatcg gccaggacga ggcggtgacc gcggtggcca
     4861 atgccgtgcg ccgttcccgc gccgggctgg ccgacccgaa ccggcccaac ggctccttcc
     4921 tgttcctcgg cccgaccggg gtgggcaaga cggagctgtg caagtcgctc gccaacttcc
     4981 tcttcgacac cgaggaggcg atggtgcgca tcgacatgtc ggagttcatg gagaagcact
     5041 ccgtggcgcg gctgatcggc gccccgcccg gctatgtcgg ctacgaggag ggcggctacc
     5101 tgaccgaggc ggtgcgccgc aagccctact cggtgctgct gctcgacgag gtggagaagg
     5161 cccacgccga cgtcttcaac atcctgttgc aggtgctgga ggatgggcgc ctgaccgacg
     5221 gccaggggcg caccgtggac tttcgcaaca cggtgatcgt gatgacctcc aacatgggct
     5281 cggacatcat ccagcgcatg ggcggcgatg actcggacta tgcccagatg aaggagatgg
     5341 tgatggcggt ggtcggcgac cacttccgcc cggaactgat caaccgcatc gacgaggtgg
     5401 tggtgttcca cgccctcggc caggcgcaga tccaggccat cgccgagata cagctcgacc
     5461 gcctgcgcgc gcggctcgcc gagcacgacc tctccctcga ggtcagcgag gcggcgctgg
     5521 gcctgctggc cgaggcggga ttcgacccgg tgttcggggc gcggccgctc aagcgggcga
     5581 tccaggcgcg catcgagaac ccgctggccc aggacctgct ggccggcaag ttctcgcccg
     5641 gcgatgtcat ccacgtggag gcggagggcg atcagctggt gttccagagc tgagcccaac
     5701 aaagcgttac cgtgccgacc gggcgtccgg tcggcaactg tctacactga aatcaggttg
     5761 cgtcctgtaa cccccttgcc cgcccggcac ccagcccggc gggctctttt atggcggcgc
     5821 gccgggcgcg tcggcccact cacgcctttt ccgcggttga caccgttgtg tcgctaatgg
     5881 aatcttggcc cttcctgatt tgcgggcgcg gaactctgcg ggcgaccccc cactcccgcg
     5941 cgaagggtag gccccatggc ctctacccgc cgaaggactt ccaggctcgg gccaaccgcc
     6001 cgtcctgacc aacgccccga cgcggcgatc cgccgcgatg agagtgcagg ccccaacagg
     6061 gccgaacaag ccagggtttg gcatcaggtg ccggcgaggc cggcagcgac ataccgtcgc
     6121 actcgacccc gtgtcccgca ttcgagacac ggatcgcact cgagacctcc aggggagaga
     6181 catcagtgga attgctttca ggcgcggaca tgatcgcccg cttcctccag gatgagggcg
     6241 tcgaatacat ctacggctat ccaggcgggg cggcgctgca catctacgac gccctgttcc
     6301 gtcaggacaa ggtcaagcac atcctggtac gccacgaaca ggccgccacc cacgccgccg
     6361 acggctacgc ccgggccgcg ggcaagcccg gtgtggtgct ggtcacctcc ggccccggcg
     6421 cgaccaacgc cgtcaccggc atcgccaccg cctacatgga ctcgatcccg atggtggtgc
     6481 tgtgtggcca ggtgatgagc cacctgatcg gcgacgacgc cttccaggag accgacatca
     6541 tcggcgtgac acgccccatc gtgaagcaca gcttctcgat caagcatccg accgagatcc
     6601 cggaagtgct gaagaaggcc ttctacctgg ccgcgaccgg ccgcccgggc ccggtggtgg
     6661 tggacattcc caaggacatg accgccccca ccgagcgcta cgagtacgtc tacccgaaga
     6721 aggtcaagat gcgctcgtac aacccggtct cccgcgggca cagcgggcag atcaagaagg
     6781 ccgtggagat gatgctcaag gccaagcgtc cggtgttcta caccggcggt ggcgtggtga
     6841 ccgggcgggc aagcgaaggg ttgaccgacc tggtaaagcg gctgggctac cccgtcacca
     6901 ccaccctgat gggcatcggc tcctatccgc agagcgatcg tcagtgtctc ggctggctgg
     6961 gcatgcacgg ctcctatgaa tccaacatgg ccatgcacca tgccgacctg atcatcgcca
     7021 tcggcgcacg cttcgatgac cgggtgacca acaacacctc caagttctgt cccacggcca
     7081 agatcatcca cgtggacatc gacccgagct cggtctccaa gaccgtgcgg gccgacgtgc
     7141 ccatcgtggg gccggccggc agcgtgatca gcgagatgat cagcctggtg cagggcaagg
     7201 aggtcgccca ccccgaggcg ctggccgagt ggtggcagaa gatcgacggc tggcgcgagg
     7261 agcgggccgg caggctctac gagccctcga agcccggcga ggccatcaag ccccaggagg
     7321 tcatcgaggc gctgtgccgg gtgacccgcg gcgaggccta cgtgaccacc gacgtgggcc
     7381 agcaccagat gttcgcggcc cagtactaca agttcgacaa gcccaaccgc ttcattacct
     7441 ccggcggcct cggcaccatg ggcttcggct tcccggcggc catgggcatc aagcagaact
     7501 tcccggacga gcaggtgatc tgcgtgaccg gcgagggcag cttccagatg atgatgcagg
     7561 agctctccac ctgtaagcag ttcggcggtg gcgtgaagat cgtcaacctg aacaacgcct
     7621 cgctggggat ggtgcggcag tggcaggacc tgaactacaa gtcccgccac gcccactcct
     7681 acatggagtc gctgcccgac ttccagaaac tgatcgagtc ctatggcttc accgcgatga
     7741 aggtcgagac cctcgaccag ctcgagccgg cactggagag aacctttgcc gacaagcacg
     7801 agctggtgtt cctcgacgtg gcggtcgacc cgcacgagca cgtctatccg atgcaggtgc
     7861 cgctgggcgc catgcgtgac atgctgcttt ccaagacgga gcggacctga tgcgccatat
     7921 catctcgatt ctgatggaaa acgaaccggg cgccctgtct cgcgtggtgg ggctgttctc
     7981 gcagcgcaac ttcaacatcg agacgctgaa cgtggcgccc accgaggacg agaccctgtc
     8041 gcgactgacc gtgaccacgg tgggggacga ccgggtgatc gagcagatca ccaagcacct
     8101 caacaagctg atcgacgtgg tcaagctggt ggacctcacc gagggcaacc acatcgagcg
     8161 cgagctgatg ctggtgaagg tcaaggcgct gggggcggcc cgtgacgagg taaagcgcac
     8221 cgtggatatc ttccgtgcgc agatcgtcga cgtgacgccg agcctctaca ccgtgcagat
     8281 caccggcgac gccggcaagc tggatgcctt cctgcaggcc atggcgccgg tggggatcct
     8341 cgaggtggcg cgtaccgggg tctccggcat cgcccgcggc gacaaggtgc tgtccctttg
     8401 atgtacgact gcgttcgctc gtgacgtaaa tcgttgcccc agcggcatac gttgcaacct
     8461 tcaggccgcc cttcggggcg gccttgctgt tttcggggca ggtgtcagcg ctccaccacc
     8521 tcgtcccata gcgcgcggat cagcgggctc ctcaggcgcc gctccagcac gcagaggccg
     8581 acgtcgtagt ggggcagttc cggcttcacc ggcagcaccc gcacccgctc caccagcggg
     8641 ctgttgtcga gcacgatctt cggcaccacg cccacgccga accccagtcc caccatgctg
     8701 acgatcgcct cgtggcctgc cacctgggcg tagatccgcg gggtgatgcc cagcgcccgg
     8761 aaccaggtat tggcaaactc ccgtgagagc cccgcctcgg aaagcaccat cggcacctgg
     8821 cgccactgct cggcactggg cgtctcgggg gtcgccggaa tccactcgtg gcggtcgtgg
     8881 ggggcgatga acaccagcgg cgagcgggtc agcgacttga aggccagcgc ctcgggcgtc
     8941 tggcgggggc gaggagtaat ggccatgtcc tcgtcgccgg ccagtacccg ggacatcgcc
     9001 tcggccgggt cgccggtgtg gagcttgagt tcgatgccgg ggtggtgggc gcggaattcg
     9061 ctgagcagtt cgtagaggaa gctgtagctg gcggtgaccg agcagtagac gctgatctcg
     9121 ccggtcaggc gccgggcctc gctcatcagc gagaggcgca gctgctccca ctgttccagg
     9181 gtctcccggg cgtagcgctg gaaggtcacc ccctggcgag tcagggccac gtggcggttg
     9241 tcgcgctcga agagtgccac gccgagggtc tcctcgagct ggcggatcga gcgcgacagc
     9301 gtcgaggggc tgacgtggca ggcttcgctg gcgcggccga agtgcagggt ctccgccagg
     9361 gccaggaagt gtttcagggg tcgcaggtcc atggggtcat tattgcataa tccggcatat
     9421 gtcgttgcat atatagcgtt ttacgcaatg gcgggtccgg cgtaaggtgg agccatcgga
     9481 tgccgcgaat cccgaccccg cgccagacgg ggcgggtggt catcaacgct gacacgatac
     9541 cttcaccata cttccaggag ttcaccatgc acgtgtatta cgacaaggat tgcgacctct
     9601 ccctcatcca gggcaagaag gtcaccatcg tgggctacgg ctcccagggc cacgcccatg
     9661 ccaacaacct gaaggagtcc ggcgtcgacg tcaccgtcgc cctgcgcgaa ggctcctcct
     9721 ccgccgccaa ggccgaggcc gccggcctca aggtcgccag cgtgcccgag gcctgcaaga
     9781 ccgccgacgt ggtgatgatc ctggccccgg acgagaacca gaaggcgatc tacgagaacg
     9841 aggtcgagcc gaacctgaag cagggcgcca ccctggcctt cgcccacggc ttcaacatcc
     9901 actacaacca gatcgagccg cgcaaggacc tggacgtgat catgatcgcg cccaaggccc
     9961 cgggccacac cgtgcgctcc gagttcgtca agggtggcgg cattcccgac ctgatcgcca
    10021 tccaccagga tgcgtccggc agtgccaagg aactcgcgct ctcctacgcc gccggcgtcg
    10081 gcggtggccg cagcggcatc atcgagacca ccttcaagga cgagaccgag accgacctct
    10141 tcggcgagca ggccgtgctg tgcggtggcg ccgtcgagct tgtcaaggcg ggcttcgaga
    10201 ccctgaccga ggcgggctac gcgccggaga tggcctactt cgagtgtctg cacgagctca
    10261 agctgatcgt cgacctgatg tacgagggcg gcatcgccaa catgaactac tccatctcca
    10321 ataacgcgga gtatggcgag tacgtgaccg gcaccgaggt gatcaacgag cagtcccgcg
    10381 aggcgatgcg caacgccctc aagcgcatcc agaccggcga gtacgccaag atgttcatcc
    10441 aggaaggcaa cagcaactat ccgtcgatga cggcccgtcg ccgcctgaac gccgagcacg
    10501 acatcgagat cgtcggcgcc aagctgcgcg gcatgatgcc gtggatcgcc gccaaccagc
    10561 tggtcgacaa gtccaagaac tgatcctcga ttggttccgg atgtacccga aggggcgcgg
    10621 acttccgcgc ccctttgctc gttcatgggg gtgaggcgcc tggggtgcgg cgttgtgggg
    10681 gcgtggcggg cgtgtagaat gatcctagcg ccccagggcg acctcattcc gacaatggac
    10741 gaaacgcatg agtcaggacc cccgcaatac cgagcatgat ctgtcgcagc ccggtaacga
    10801 gactcccggc gaggcggccg ccgacagggc gcctcccgcg gaggaggatc tggcggcggc
    10861 cttcgtgcgc gagacggaag tcatcgagga ggccgtggag aacgggcaga aggtgcgccg
    10921 caagggcatt tacctgctgc ccaacctgtt caccacctcc gccttgtttg ccggcttctt
    10981 cgccgtggtg gcaggcatca acggcgactt caccgcggcg gcggtggcca tcttcatcgc
    11041 catggtgctc gacggcctgg atggtcgcgt ggcgcgcatg accaataccc agagcgcctt
    11101 cggtgccgag tatgacagcc tggccgacat gctctccttc ggcgtggcgc cggccctggt
    11161 cgccttcacc tggattctgc aggacatcgg caagaccggc tgggtggtgg ccttcctcta
    11221 cgtggcctgt gccgcgctgc gcctggcgcg cttcaacgtg cagatcggca gcgtcgacaa
    11281 gaagtggttc atcggcctgc ccagtccgtc ggcggcggcc ctggtggcgg ccagcgtctg
    11341 gaccttccac accctggatg ccgaggcctt cggcttcaag ctgctgatgc tgttcatcgt
    11401 cggggccgcc ggggtgctga tggtcagcaa catccgctac cacagcttca aggagatcga
    11461 tctcaagggg ccggtgccct tcgtggtgct gctggccatc gtgctcggct tcgtggtgat
    11521 ctccgtgcag ccgtcggtga tgctgctgct gctgttcggc gcctacgtgg cctccggtcc
    11581 ggtcatggcg gcgatgcgca agctcaagca tgcgccgccg acggcctgac ccgcctgcca
    11641 cgctcctctc gacgcccgcc ccgcgcgggc gttctcgtcc gggcgccacg gcttgtccac
    11701 agccctcggg cgccagggcg ctgtggatag cccggggcgg cacgctggcg caacggcttc
    11761 cccgttctgc caccgtcctg acattttttt accggaaggg cttgcggggt cccggggaag
    11821 tccgtaaagt acgcatccgc tgccggcgac gggcaacgtt gcaggcggtg aaaggtggga
    11881 gaagtggttg ttctgcttgg ggttttcgaa aacgccccgc ttgacagtca ccgcggattc
    11941 ggtagaatgc gccccgcacg aatcgcagcc acctcgatag ggtggggcgg tcggcagcca
    12001 cggcaagttc gcttcgccaa cccctgcttg acacgccgaa gcgaatcggt agaatacgcc
    12061 ttcctcgcag ggcgctggcg aggcccgccg gatcatggat ccgcggccac ggcagcaagc
    12121 gagacgctcc gctcttttca tcgagcccgg agccgctctt taacaatcga tcaggtaatt
    12181 catgtgggcg cttgtcgatg tgtcggt
//
