LOCUS       NZ_LT699723.1          15002 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_LT699723.1 Merdibacter massiliensis strain Marseille-P3254T,
            whole genome shotgun sequence.
ACCESSION   NZ_LT699723
VERSION     NZ_LT699723.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 01:23:04
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 42656
            Orig. end    :: 57658
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15002
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[52656:57409]"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14753
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
     cand_cluster    1..15002
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /kind="single"
                     /product="acetate2butyrate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15002
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="acetate2butyrate"
                     /region_number="1"
                     /rules="(not (POR or POR_N or PFOR_II) and minimum(4,
                     [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF, ETF_alpha,
                     HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and minimum(1,
                     [EC1_2-faecali, ECH1_Enoyl_CoA_DH1, ECH1_Enoyl_CoA_DH2,
                     ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4, Thiolase_C]))"
                     /tool="gutsmash"
     CDS             239..991
                     /locus_tag="ctg17_49"
                     /transl_table=11
                     /translation="MIFKKEVWMTPYQMMRTLHIYVPDEVQSSKQRYPVFYMYDGHNLF
                     DDAEATYGKSWGLKEYLDGQKEKRIIVGIECNHEGNQRIVEYCPYTFYDHRLGTIVGSG
                     KQMMEWVVQELKPLIDQELPTLPDRNHTWIGGSSMGGLMALYSITYHNAVFSRAACLSP
                     FLGPVRKQIAQDCQLLLQTDTYIYLSWGSNESRSKRGFTYMSKVNIEIANLLYQQDIHL
                     RLNLVPGGQHCEASWEKEIPTFFQFFKQ"
     CDS             1085..2170
                     /locus_tag="ctg17_50"
                     /transl_table=11
                     /translation="MDRSVQTRYLHENKQRIIAISDIHGNLSLLKTLLDQVHYDEYEDT
                     LLFLGDLIEKGNENLATLRYIMNLCQNGNAYALMGNCDFVCKNIVHHYNLHFLNKILCQ
                     RQASILHEMAAQIGISIDQSTDMERLCDRLLAHFFKELHWVDTLPQVIYTDNYIFVHAG
                     ILNEQTFGSDFREVLTFPHFLLNGKDFKHYVVAGHMPVSEYCQDIACFNPIINEQKHII
                     SIDGGNMVKKAGQLNALIIQNDRFSFKSADSLPLAQALCDVNVKNQDPLFITWRESEIV
                     RLEKGEKRDFCLHLSSGKKLWIDHAFLHNEDGKWKADDFTTYQMPLKRGEYVSIVKTYD
                     QFALIKKEGILGWCRKEHLRC"
     CDS             complement(2184..3209)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Beta_elim_lyase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg17_51"
                     /sec_met_domain="Beta_elim_lyase (E-value: 1.6e-38,
                     bitscore: 124.6, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISFVNDYSEGACDEILQRLKETNHLQSCGYGLDEYCQAAADKIK
                     KVIACEDCDVHFLVGGTQCNKTVIAAALRPHEAVICAESGHINVHETGAVENSGHKVLY
                     AKGEDGKITPKEIEQIVLKHTDEHMVKPAMVYLSDATELGTYYTYNELKAISECCHAHH
                     LYLFLDGARLGNALCAKDNDLKIEDLPKLCDVFYIGGTKNGALFGEALVIVNPALKPDF
                     RYHIKQNGGMLAKGRLLGIQFEVLFEGDLYFRLANHANAMAQQIAQTLRECHVDFLFES
                     QTNQIFPIFTQSELQTLRQHFELGDWEKLDDEHTAIRIVTSWDTKEEAVKQFCETVMKL
                     R"
     CDS             3336..4376
                     /locus_tag="ctg17_52"
                     /transl_table=11
                     /translation="MFEINESYLFDFAKKLLSIDSPSGYTMHAIHFMEEEAKSLGYTCE
                     HNAKGNLLIRVPGYDSTHTLALSAHCDTLGLMVRSIKENGTLAVTPIGSPTLPTLDSEY
                     CRVLTRDGKVYTGTILCKAAAKHVHPDASTLTRDADTLEVRIDEVVKTKADVENLGIQN
                     GDYIAIDPKTVITKSGFIKSRFLDDKISCSCLFSVLHYIKENNLRFKNDLLFVFSTFEE
                     VGHGASSMPSDVDTMLAVDMGCIGLDLACSEYDVSICAKDSSGPYDYAMTSTLISLAKD
                     NQLNYAVDIYPMYGSDVSAALKGGNDIKGALIGPGVHASHGMERTHISALKSTISLVLA
                     YLSANK"
     CDS             complement(4447..6423)
                     /locus_tag="ctg17_53"
                     /transl_table=11
                     /translation="MINQTENFEQGVFQTKGKFYIQGRSGSGKTTLLLKRLQYLREEGI
                     SFKKVLNLTAYKEDTKNLERLWKESYDPCGEDVPSFKSIYQFCFQILYRYHQLYGGTQP
                     HVSRDFRLQVSKMIQEFFGIQLNHYELDEVYKQLCICRGQLMDEAQIQQITYPNMNFYY
                     LFQQFEKYKKQRSLMSYEDLMVEAYQCLLKEESLRRQIREQIRFIHVDDAQNLSLAAHK
                     MLQLISDEQSSVALFIDNDQYAGSHAPYRLRYEEFLNIFPDAVKIELDHNYRCDANIDE
                     MIQKFMHSDYDFHLQDDSVVRFLTAKDLDASYHQALILAKNDSNMVFLSREHFTLLPLA
                     DLLDKENIPFHVSNFHSFFRDNTIHDLLALFRLMMDPKDYYAFTLIQKKIGFGLSDRNL
                     NEIEQMLQEDDSLDIYSAIFNSSIRSSTKNRVIKHIEEIRIAQHLDSIKMLLFVLTKLH
                     YEDYIKQKGVTIKNPNILVFATMAQRYKDPAELLERFKHLMSIEDEQEHSISLYSFSQV
                     KGKVFEEVCFLDCLDAFYQVFPDQIQEKRFLYSILSKISKRMVFLVAKTAFMQKMTPHA
                     FIHDLYLLMKAKDAGERKERKTKEVSKATLRSGKRIVHKTLGNGRIRRIFPEDDEIEIV
                     FADGVAKRLKLSACLESALLSFH"
     CDS             complement(6754..8337)
                     /locus_tag="ctg17_54"
                     /transl_table=11
                     /translation="MKNIEVLELNHSYLSNRNYTAFQMILPLDCEKKIDSSDPVYSFLE
                     VMEGVNWNKYLNHPAHRGREEYNPFKMIKVILFAFMNHIYSLRDIEKSCRTDIRFMFLM
                     QEETPSHMAFHRFIQKYLKYDIQFIFRDIFESIEILDPSIDHDTVYIDGTKLEANANKF
                     TFIWKKTAIKTRDKIFTRLNEWVRKLGDRIEASQKEEWTIKDIENMANQIFHIVEQEGI
                     TFIYGKGKRKSQIQHYYDELMKYKETLQNCLERIELCGPDRNSCSKTDHDATMMHMKED
                     HYMKTGIFKAGYNAQIAVSSEYIQLACIYQDRTDQKTFIKFLETFRALYNRMPKTVAAD
                     AGYGSYDNYFFCLENDMEAYIKYMMYSKEKETSYKKKTFIKSNWNRNGNGRYICPAGHE
                     FGCINETVDKRSKYYRINQTHSCGKCTDCPLKSQCTKAKGDRTISVNPILEEFERTARK
                     KLNSEEGIHHRVQRSIQSEGAFGVIKEDYAYDRLHRRSIKNVEMEFLLVCVGFNLMKYH
                     NKKIRKKAQA"
     CDS             complement(8402..9979)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CoA_trans_230_acto"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg17_55"
                     /sec_met_domain="CoA_trans_230_acto (E-value: 7.2e-101,
                     bitscore: 328.4, seeds: 30, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKIISLEKAVSMIPDGATVGIGGFIGCGHPQEFSVGIEESFLKS
                     GHPRDLTIMFSAGIGDGTDKLGLNKIGHEGLLKRIIGGHWGLIPKLQQLVFENKVEGYN
                     LPLGTISLMFREIAGHRPGVITKIGLKTFVDPRLEGGKMNERTKEDLVELIEMDGEEWL
                     RYKSFPVNVALIRATYCDEDGNATMDKEAATLDSLAIAQAAKNSGGIVLLQVEKVVQNG
                     TLDARKVKIPGIYVDGIVISRPENHWQTYEAYYNPALCGEVKVPVDSIPPMKLNERKVI
                     CRRAAMELDPHAIINLGIGMPEGIANVANEEGLPGLKLTVETGGIGGVPMAGTAFGTCT
                     NPTAILDQPYQFDFYDGGGLDQAFLGLAECDRFGNINVSRFGPKIAGCGGFINITQTAP
                     VVVYCGTFTAGGLKVEVKDGQLHILQEGRIKKFIKDVEQVTFGAAYAKETGQKVLYITE
                     RAVFELLDGVLTLTEIAPGVDLEKDIMAHMEFRPAVSENLKEMDARIFRDEIMGLLEEK
                     EEAVTNKE"
     CDS             complement(10001..10780)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: EC1_2-faecali"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_56"
                     /sec_met_domain="EC1_2-faecali (E-value: 3.9e-90, bitscore:
                     293.5, seeds: 67, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METVLIAKEGHVATITINRPKALNALSTEVLTELNAALDEVAADK
                     DVYALVITGAGEKSFVAGADIAEMKDKTVEEAATYGKFGNEVFRKIETFRCPVIAAVNG
                     FALGGGCELAMSCDIRIAGDNAVFGQPEVGLGITPGFGGTQRLARLVGAGIAKEMIYTA
                     RNIKADRAAEIGLVNKVVPAGELMETVMKMANGIAKNAPIAVANAKKAINEGLQCDIDG
                     GIAIEVKEFSDCFASEDQTYGMTCFLEKVKDKQFSNK"
     CDS             complement(10871..11710)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_57"
                     /sec_met_domain="HCDH (E-value: 1.6e-37, bitscore: 120.1,
                     seeds: 68, tool: rule-based-clusters)"
                     /sec_met_domain="HCDH_N (E-value: 4.9e-60, bitscore: 194.4,
                     seeds: 60, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVGVIGAGTMGQGIANAFATNGYDVTVCDIKLEWAQGGIDKIG
                     KKLDKLVSREKMTAEKAAEIKGNLKAGEYADLADCDLIVEAVLEIMDTKKELFSQLDEI
                     CKEDCIFATNTSSLSVTEIAKGIKHHVIGMHFFNPADRMKLVEVISGINTPVETKEAII
                     EISKSLGKTPVEVAEGPGFVVNRILVPMINEAAFILQEGIASAEDIDTAMKLGANHPMG
                     PLALGDLIGLDIVVAIMDVLFAETHDPKYRCCTLLRKMVRGGKLGQKSGIGFYDYSK"
     CDS             complement(11753..12781)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF_alpha"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 155;
                     E-value: 6.5e-48)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_58"
                     /sec_met_domain="ETF (E-value: 6.4e-48, bitscore: 155.0,
                     seeds: 129, tool: rule-based-clusters)"
                     /sec_met_domain="ETF_alpha (E-value: 9.8e-33, bitscore:
                     104.1, seeds: 511, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKFEGYKDIYVFVEQKNGEIANVGYELISEARKLVASIPSLGFK
                     VVGVLLGHNIADKANEVIAHGADKVIVVDDALLESYSTQFYADALTQVINEFKPDSFLT
                     GATVLGRDLAPRVAARLNAGLTADATKIEMDQTKVADGEALLLVTRPTFGGNLFGTIIC
                     PNTRPQMATIRPNVFAMDAPDASRTGEVVTFSPKWTDTDPKVVVKKVIEKVVEGVDITK
                     ADILVAAGRGAEDCLDMVKAVAEELGGEMCASRAVVDDGFVDKAIQVGQTGKTVRPSLY
                     IACGISGACQHVAGMEKSDMIIAINRDPQAEIFSIANMGFIGDVKEILPLLKDEIIAAK
                     KA"
     CDS             complement(12795..13583)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 154;
                     E-value: 1.3e-47)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_59"
                     /sec_met_domain="ETF (E-value: 1.3e-47, bitscore: 154.0,
                     seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIIVLVKQVPDSTEIRVDKVTGTLIRAGVPSIINPDDLAGVEAA
                     LQLKEKYGATVVAVSMGPGQAGDMLKELYARGVDECVLITDRKFGGADTCATSTTLAGA
                     LKKIGYDLIIAGRQAIDGDTAQVGPQTAERLGIPQVTYVDEIIELTDKTVTVKKSLEDC
                     EEIIEAKLPCVLTTLSGMNEPRYMNCNDIVDSFSKELTIFTFDDLGIDESLVGLAGSPT
                     KVHATFTKDVSAETETFDMPAAEAAKLIAKTLKEKQIITK"
     CDS             complement(13614..14753)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_60"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 3e-53, bitscore:
                     172.0, seeds: 49, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 9.7e-32, bitscore:
                     101.1, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.8e-37, bitscore:
                     120.5, seeds: 796, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFMLTEQQQMMKKLFAEFAEKEVKPLAAEVDEEERFPRETVEKM
                     KACKMLGIPYSREYGGAGADYLCYILAVEELSKKCGTTGVVLSAHTSLGTWPIAQFGTP
                     EQKAKYLPDLCTGKKLAAFGLTEPNAGTDAAGQQTTAVKDGEDYILNGTKIFITNAGEA
                     DVYIIFAMTDKSKGTHGISAFIVEKGMPGFTFGQHEKKLGIRGSATSELIFNNVRLSKD
                     QLLGQEGKGFKIAMMTLDGGRIGIAAQALGIAQGAIDEVVPYVKSRKQFGRAIAKFQNT
                     QFQLADMQTKVDAARWLVYDAAMKKEKGMPYTVEAAKAKLFAAEVAMEVTTKAIQLMGG
                     YGYTRDYPVERMFRDAKITEIYEGTSEVQRMVISGAMLK"
     CDS             complement(14859..15002)
                     /locus_tag="ctg17_61"
                     /transl_table=11
                     /translation="HAGKCQLMQSIFPKENADKALKYRLYRHLPAYEKIIRNLVSFCLL
                     KF"
ORIGIN
        1 ggaaagccgg ctcctgatat ttatgaatgt gctgccaaac ggttgcatgt tcccatcaag
       61 caatgcatcg ttgttgaaga ctcccctagc ggtattttag ctgccgatgc agcacaagcg
      121 atgccgctgt tgattcccga tgctgcttat gtcaacgatg ctattcgaaa gaaagccaaa
      181 tggatcttaa agagcttgga tgaaatgatt cctctattag aaaaggagga aagctcatat
      241 gatatttaaa aaagaagttt ggatgacccc ttatcagatg atgcggacac tgcatattta
      301 tgtgccggat gaagtgcagt cttccaaaca gcgctatcct gttttttata tgtatgacgg
      361 acacaatctt ttcgatgacg cagaagctac ttatggaaaa tcctggggat taaaagaata
      421 tcttgacgga caaaaagaaa aaaggatcat tgttggaata gagtgcaatc atgagggaaa
      481 tcaacgtatc gtcgaatatt gtccatatac tttttatgac catcgtctag gaacaatcgt
      541 gggcagcggc aaacaaatga tggaatgggt cgtacaggaa ttaaaacctt tgatcgatca
      601 ggaactgcct actcttccag ataggaacca tacatggatc ggcggcagtt ctatgggcgg
      661 actcatggca ttgtattcaa tcacctatca caacgccgtc ttttcaaggg cagcttgttt
      721 atctccgttt ttaggtccag tgcgaaaaca aattgcccaa gattgccagc ttttgcttca
      781 aacagatacc tatatttatc tttcttgggg aagtaatgaa tcacgctcta aaagaggctt
      841 tacttatatg agcaaagtca atatagaaat agccaactta ttgtatcaac aagacatcca
      901 tctccgcttg aatcttgtgc ctggcggaca acattgtgag gcttcttggg agaaagagat
      961 tcccactttc tttcaattct tcaaacagta agcatgaact tactgttttt ttctgtttag
     1021 tgcttaaatg gacttttatc tcttttttat ctataataaa acctgataag aaaggagcat
     1081 accgatggat cgcagcgtac agacaagata tcttcatgaa aacaagcaac ggatcattgc
     1141 catttctgat atacacggca atctttcttt gcttaaaaca cttttagatc aagtacacta
     1201 tgatgaatat gaagatacat tgcttttcct aggtgatcta atagaaaaag ggaatgaaaa
     1261 ccttgcgaca ttacgataca tcatgaacct ttgtcaaaat gggaatgcct atgctttaat
     1321 gggaaattgt gattttgtct gcaaaaatat cgttcatcac tacaatttgc attttttaaa
     1381 caagatctta tgtcaaaggc aagcaagcat tctgcatgaa atggcagcac aaatcggcat
     1441 cagtattgac caatcaacag atatggaacg gctttgcgat cggctgctcg cgcatttttt
     1501 caaagaactg cattgggtgg atacactccc ccaagtcatt tacacagaca attacatttt
     1561 tgtccatgca ggtattctca acgaacagac attcggcagc gactttcgtg aagtactgac
     1621 ttttcctcat ttcttattaa atggaaaaga tttcaaacac tatgttgttg ctggccatat
     1681 gccagtgagc gaatactgtc aagatattgc ttgtttcaat ccgatcataa acgaacaaaa
     1741 acacatcata tccatcgatg gcggcaatat ggtgaaaaaa gcaggacagt taaatgcttt
     1801 gatcattcaa aatgatcgtt tttctttcaa aagtgcggat tcgctgcctc ttgcacaagc
     1861 actttgcgat gtcaatgtca aaaatcaaga tccattgttc atcacatgga gagaaagtga
     1921 aatcgttcgt ttagaaaaag gagaaaaacg tgatttttgt ttacatcttt cctccggtaa
     1981 aaaactttgg atcgaccatg cttttctaca taatgaggat ggaaaatgga aagcagatga
     2041 ttttacgacc tatcaaatgc cattgaaacg tggagaatat gtttcgatag taaaaacata
     2101 tgaccaattt gcactcataa aaaaagaagg aatcttaggt tggtgtcgaa aagaacactt
     2161 acgctgctga ttcctttttc ttattatcgt aatttcatga cagtttcgca aaattgtttg
     2221 actgcttctt cttttgtatc ccaagaagta acgattcgaa tagctgtatg ctcatcatcc
     2281 aatttttccc aatcgccaag ttcaaaatgt tgacgaaggg tttgcagttc gctttgagtg
     2341 aagattggaa aaatttgatt tgtctgtgat tcaaataaga aatcaacatg acactcacgc
     2401 aaagtctgcg caatctgttg agccatcgca ttggcatggt ttgccaatcg aaaataaaga
     2461 tccccctcaa acaacacctc aaattgaatt cccagtaagc ggccttttgc cagcatacct
     2521 ccattttgtt tgatgtggta acgaaaatcc ggttttaatg ctgggtttac aataactaaa
     2581 gcttcaccga acaatgcccc gttttttgta ccgccaatgt agaatacgtc gcataatttt
     2641 ggcaagtctt caatctttaa atcattatct tttgcacata aggcatttcc taaacgcgca
     2701 ccatctaaaa atagatataa gtgatgtgca tggcagcatt cactaattgc ttttagctca
     2761 ttatatgtat aataggtacc caattccgtg gcatccgata aatagaccat ggccggcttg
     2821 accatatgtt catccgtatg tttcaacacg atttgttcaa tttctttagg cgtgattttc
     2881 ccgtcttccc cttttgcata cagcacttta tgaccgctgt tttctactgc accagtttca
     2941 tgaacgttga tgtgtccact ttctgcacag ataacagctt catgcggccg taatgcagct
     3001 gcaattacgg ttttattaca ttgtgttccc cctactaaaa aatgaacatc acaatcttcg
     3061 caagcaatga cttttttgat cttatctgcc gcagcttggc aatattcatc cagcccatac
     3121 ccgcagctct gcaaatgatt tgtttctttt aaacgttgca atatctcgtc acatgctccc
     3181 tcactataat catttacaaa tgaaatcatt ttctattcct tctttccttt atcaaactgt
     3241 aattagaata ccacaactca tgcatattga aaatcccatt ccttgcattt ataaaaaaat
     3301 agcctatact tatacgtgat aatggaggta aaactatgtt tgaaatcaac gaatcttatt
     3361 tatttgattt tgcaaaaaaa cttttgtcca tcgattctcc tagcggctat acgatgcatg
     3421 caatccattt catggaagaa gaggcaaaat cgcttggtta tacatgtgag cacaatgcaa
     3481 aggggaattt gctcatccgt gttcctggat atgattccac gcataccctt gctttaagcg
     3541 cccattgcga tactcttggt ctcatggtgc gttccatcaa ggaaaatggt accctcgctg
     3601 taacaccaat cggctctcct acactgccta ctttagacag tgaatattgc cgtgtcctta
     3661 cacgcgatgg caaagtatat actggcacca tcttatgcaa ggcagcagca aaacacgtac
     3721 acccggatgc ttccacattg accagagatg cggataccct ggaagttcga atcgatgaag
     3781 tcgtaaaaac aaaggctgat gtagaaaatc tgggaattca aaatggagat tatattgcaa
     3841 tcgatcccaa aactgtgatc accaaaagcg gatttatcaa atctcgtttt cttgatgata
     3901 agatcagctg ttcttgttta ttttctgtct tgcattatat caaggagaat aacttaagat
     3961 ttaaaaatga tttgctattt gtcttcagta catttgaaga agtaggacat ggtgcaagca
     4021 gcatgccgag cgacgtagat acgatgctcg ctgttgatat gggatgcatc ggtctggatc
     4081 ttgcatgcag cgaatatgat gtcagcatct gcgcgaaaga tagcagcggg ccatatgatt
     4141 acgcaatgac aagcacactg atttcattgg caaaagacaa tcaattaaac tatgcagttg
     4201 atatctatcc tatgtatggc agcgatgtct ctgcagcatt aaaaggcggc aatgatatta
     4261 aaggagcatt gatcggacct ggtgtgcatg cctcacatgg aatggagcga acacacatca
     4321 gtgcattaaa aagtacgatt tctcttgtat tagcctattt atctgccaat aaataaaata
     4381 aaaagacagg atgctatttt atctttgatc aaaacgatca cagataaaat agataaactg
     4441 tcttttttaa tgaaatgaca ataatgcact ctctagacaa gccgaaagct ttagtctttt
     4501 tgcaacaccg tccgcaaata cgatttcaat ctcgtcatct tctggaaaga ttcgccgaat
     4561 gcgtccattg cctaaagttt tatgaacaat tcgttttccc gaccgtaatg ttgccttcga
     4621 cacttctttt gtctttcttt cttttctttc cccagcatct tttgctttca tcaacaaata
     4681 taaatcgtga atgaatgcat gtggtgtcat tttctgcata aatgcagtct ttgcaaccaa
     4741 gaagaccata cgtttcgata ttttagacaa gatgctgtaa agaaatcttt tttcttgaat
     4801 ctggtccggg aacacttgat aaaaagcatc tagacaatcc aaaaagcaca cttcttcaaa
     4861 aactttccct tttacttgcg aaaaactata aagagaaatg gaatgttctt gttcatcttc
     4921 tatgctcatc aaatgtttga accgctctaa taattctgcc ggatccttat aacgttgcgc
     4981 catcgtggca aataccagaa tgttaggatt tttgatcgta acacctttct gtttaatata
     5041 atcttcataa tgcagttttg ttaagacaaa taacagcatt ttgatggagt ccagatgttg
     5101 tgcaatacgg atttcctcaa tgtgtttgat aactctattt tttgtggaag agcgtatcga
     5161 actattgaat atagcgctat aaatatctaa actgtcatct tcctgcagca tttgttcgat
     5221 ctcgtttaaa tttcgatcac tcaaaccaaa tccaattttt ttctgaatca aagtaaacgc
     5281 ataataatct ttcggatcca tcatcaaacg aaacaaagct aacagatcat gaatggtatt
     5341 gtcacggaaa aagctgtgaa aattagacac atggaacgga atgttctctt tgtctaacaa
     5401 atctgctaat ggcaataatg taaaatgttc tctacttaaa aataccatat ttgaatcatt
     5461 ttttgctaaa atgagagctt ggtgataaga agcatctaag tcttttgctg tcagaaagcg
     5521 gacaacagaa tcgtcttgca gatggaaatc ataatcacta tgcataaatt tttgtatcat
     5581 ttcatcgata tttgcatcac accggtaatt atgatccagc tcaattttga cagcatccgg
     5641 aaaaatattt aaaaattctt catatcgcag gcgatatgga gcatgcgaac ctgcatattg
     5701 atcattatcg atgaataaag caaccgaact ttgttcatcg ctgatcaatt gcagcatctt
     5761 atgtgcagcc aacgataaat tttgggcatc atctacatga ataaaacgaa tttgttcacg
     5821 tatctgccgg cgtaagctct cctctttcaa aagacattgg tatgcttcta ccatcaagtc
     5881 ttcataactc attaaagaac gctgcttttt atatttttca aactgctgga ataaataata
     5941 aaaattcata tttggatatg tgatctgctg tatctgcgcc tcatccatca gctgtccgcg
     6001 acagatacaa agttgtttat acacttcatc caattcataa tgattaagct gtataccaaa
     6061 aaattcttga atcatcttag agacttgcag tcgaaaatct cgtgacacgt gcggttgtgt
     6121 accgccatat aattgatgat atcgatacaa tatttgaaaa caaaactgat aaatagactt
     6181 gaaggaaggt acatcctcac cacacggatc ataactctct ttccataagc gttccaaatt
     6241 ttttgtgtct tccttatatg cagtaagatt cagtactttt ttaaaagaaa ttccttcttc
     6301 tcgtaaatac tgtaatcttt ttaacaacaa tgtcgtcttt ccactgccag aacgcccttg
     6361 aatataaaat tttccctttg tttgaaaaac tccttgttca aaattttccg tctggttgat
     6421 catgcatatc cccttcctat aataatcgaa catgtttata attatatctc atttttgaaa
     6481 tcatttcatc aaaaaaatca ataaaatgta agacacaaaa aaatcaataa aatgtaagat
     6541 atttgttcat gtaataatac aaatttacag catatatcaa atcaattaaa aagaggctgt
     6601 aacgaaatag aagattttaa ttaaacgaat ctgtctattg aggttacgac ctcttttttc
     6661 ttttctttac tttgaaattg tttcaattct cccaattatc cctgtttttt ggcattatga
     6721 aaacacctat tgtggaaaac ccatcaacat tatttatgct tgtgcttttt ttcttatttt
     6781 tttgttatga tatttcatca gattaaagcc tacgcacacc aacaggaact ccatttctac
     6841 atttttgatg cttctcctat gtaatctgtc ataagcataa tcttctttta tcactccaaa
     6901 agctccttcg ctttgtatgg atctttgcac tcgatgatgg attccttctt cgctatttag
     6961 tttttttctc gctgttcttt caaactcctc aagtatcgga ttcacgctta tcgttcgatc
     7021 tcccttggct ttcgtacatt gagatttgag tgggcaatcc gtgcatttgc cacagctgtg
     7081 cgtttgattg attcgataat atttgcttct cttatcaacc gtttcattga tacagccaaa
     7141 ttcatgtcct gccgggcaga tatatcttcc atttccattt ctgttccagt ttgatttgat
     7201 gaatgttttt ttcttgtagc tcgtttcttt ttcttttgaa tacatcatat atttgatata
     7261 ggcttccata tcattttcta aacagaagaa ataattatca taggatccat atcctgcatc
     7321 cgctgctact gttttaggca tcctgttata aagtgctctg aatgtttcaa gaaatttgat
     7381 aaatgtcttt tgatcggttc tatcctgata gatacaagcc aattggatat attcactgct
     7441 tactgctatc tgtgcattgt atcctgcctt gaagattcct gtcttcatat aatggtcctc
     7501 tttcatgtgc atcatcgttg catcgtggtc tgttttcgaa cagctgtttc tgtcaggtcc
     7561 gcatagttca attctttcca aacagttttg cagtgtttct ttgtatttca tcaattcatc
     7621 ataataatgc tggatctggc tttttcgctt accttttcca taaatgaaag tgattccctc
     7681 ttgttcaacg atatgaaaaa tttggttagc catattttct atgtctttta ttgtccactc
     7741 ctctttttga gatgcttcaa tacgatcacc cagtttcctg acccattcgt ttaatcgagt
     7801 gaatatttta tctcttgttt tgattgcggt ctttttccag atgaaagtaa acttgttggc
     7861 attggcctca agcttggttc catcaatata aaccgtatca tgatcaattg acggatctaa
     7921 tatctcaatt gattcaaata tatctctaaa aatgaattgg atgtcatatt ttaaatactt
     7981 ttggatgaaa cgatgaaatg ccatgtgact tggcgtttcc tcctgcatca agaacatgaa
     8041 acggatgtct gttctacagc ttttttcaat atctcttaga ctataaatat gattcatgaa
     8101 cgcaaacagg atgactttga tcatcttgaa gggattatat tcttcacgcc ctctgtgagc
     8161 agggtgatta agatatttgt tccagttgac tccttccatc acttcaagaa aactgtacac
     8221 cggatcagaa gaatcgatct ttttttcaca atccagtggt aaaatcatct gaaatgcggt
     8281 ataattccta ttgctcaaat aggaatgatt tagctctaac acttcgatgt ttttcatagc
     8341 taaattatac caaaaaatgc atcctttctc tttcgagatt agatgcattt tttatttttg
     8401 gctattcctt attcgttaca gcctcttctt tttcttcaag cagccccatg atctcatcac
     8461 ggaagatgcg ggcatccatc tctttcagat tttctgaaac agctggacgg aattccatat
     8521 gagccatgat gtctttttct aaatcaacac caggcgcaat ttctgttaat gttaatacac
     8581 catctagcag ttcgaatact gcacgttctg taatgtataa cactttctgt cctgtttctt
     8641 ttgcgtaagc agctccaaat gttacttgtt caacatcttt gataaacttt ttgattctgc
     8701 cttcctgcag gatatgcaac tgcccatctt ttacttctac ttttaaaccg ccagcggtaa
     8761 aagttccaca gtaaacgaca acaggcgctg tttgcgtaat gttgataaag ccaccacaac
     8821 cggctatttt tggtccaaag cgggaaacat tgatattacc aaaacgatca cattctgcta
     8881 atcctaagaa agcttgatct agaccgccgc catcataaaa gtcaaactga taaggctgat
     8941 ctaagatagc agttggattt gtacatgtac caaaagcagt acctgccatc ggtactccgc
     9001 caataccacc tgtttcaacg gttagtttta aaccaggtaa accttcttca tttgcaacat
     9061 ttgcaatacc ttccggcata ccgataccta aattgatgat tgcatgcgga tctaattcca
     9121 ttgcagcacg acggcagatg accttgcgtt cattcaattt cattggtgga atagaatcaa
     9181 caggtacttt tacctctcca cataaagctg ggttgtaata tgcttcatat gtctgccaat
     9241 ggttctctgg acgggaaata acgatgccat ccacataaat gcctgggatt tttacttttc
     9301 gcgcatctaa tgtaccgttt tgaacaactt tttcaacctg caacaacaca ataccgccag
     9361 aattttttgc agcctgtgca atggctaatg aatccaacgt tgcagcttct ttatccattg
     9421 ttgcgtttcc atcctcatca caataagttg cacggatcaa agcaacattg accgggaatg
     9481 acttataacg cagccactct tcaccatcca tttcaatcaa ttctactaaa tcttcttttg
     9541 tacgctcatt catctttccg ccttctaatc gtggatcgac aaatgtcttt aaaccgatct
     9601 tggtaatgac accgggacga tgtcctgcaa tttcacggaa catcagcgaa atcgtaccca
     9661 atggcaaatt gtatccctct actttatttt caaataccaa ttgctgcagc tttggaatca
     9721 atccccaatg tccgccgata attcttttta gcaaaccttc atgcccgatc ttgttcaaac
     9781 caagtttatc tgttccatca ccgataccag cagagaacat gatcgttaga tcacgcggat
     9841 gtccgctttt caaaaagctt tcttcaattc caactgaaaa ttcctgcgga tgtccacaac
     9901 cgataaatcc gccgatacca acagttgcac catcaggaat catggaaaca gctttttcca
     9961 aagagattat tttactcatc tacatatcac cttttcattt ctacttatta gaaaactgtt
    10021 tgtccttcac tttttcaagg aagcaagtca taccataagt ctgatcttca cttgcaaagc
    10081 aatcagagaa ttcttttact tcgattgcga taccgccatc gatatcacac tgtaaacctt
    10141 cgttaatagc tttttttgca tttgcaacag caattggcgc atttttagca atgccatttg
    10201 ccattttcat gactgtttcc attaattcac cggctggtac cactttattt accaaaccaa
    10261 tttctgcagc acgatctgct ttgatattac gggcagtata aatcatttct ttggcaatgc
    10321 ctgcaccgac caaacgtgct aaacgttgag tacctccaaa accaggcgta attcctaatc
    10381 ctacttctgg ctgaccaaat acggcattat caccggcaat gcgaatatca caactcattg
    10441 ccagttcgca gccgccgcct aatgcgaaac catttacggc tgcaatgaca ggacaacgga
    10501 atgtttcgat cttacggaac acttcattac caaatttacc atatgtagca gcttcttcta
    10561 ctgttttatc tttcatttct gctatatctg caccggcaac aaatgatttt tcaccagcac
    10621 cagtaataac taaagcatat acatctttgt ctgcagcaac ttcatcaagt gcagcattca
    10681 attctgtcaa tacttctgtg cttaaagcat tcaatgcttt gggacgattg atcgtaatag
    10741 ttgcaacatg accttctttt gcaattaata ctgtttccat attttataag cctacctttc
    10801 tttttaaaaa gtgaatccat caactcctat gtgaatggaa tggattcact ttctattatt
    10861 ctatatttaa ctatttactg taatcgtaga atccgatacc gctcttttga cccaatttgc
    10921 cgccacgtac catttttctt aataatgtgc agcaacgata ttttggatcg tgtgtctcag
    10981 caaagagtac atccataata gcaacgacaa tatccaaacc aatcaaatca cctaaagcta
    11041 aaggtcccat tggatggtta gcgcctaatt tcattgctgt atcaatatct tcagcagaag
    11101 caataccttc ctgcaggatg aaagctgctt cgttgatcat tggtaccaag atacggttta
    11161 caacaaatcc tggaccctct gctacttcaa ctggagtctt acctaaagat ttgctgattt
    11221 cgatgattgc ttcttttgtc tcaacaggtg tgttgatacc agaaataacc tctaccaatt
    11281 tcatacgatc tgccgggtta aagaaatgca tgccaattac gtgatgcttg attccttttg
    11341 caatttctgt tacggataaa gaagaagtgt ttgttgcaaa aatgcagtct tctttacaaa
    11401 tttcatccaa ctgagagaac agctctttct ttgtatccat gatttccaaa actgcttcta
    11461 cgatcaaatc gcaatcagca agatctgcat attctccagc ttttaagtta cctttgattt
    11521 ctgctgcttt ttcggcagtc attttttcac ggctaaccag tttatctaat tttttaccga
    11581 ttttatcaat tccgccttgt gcccattcca gcttgatgtc acaaactgtt acatcatatc
    11641 catttgtagc gaatgcattt gcaatgcctt gacccattgt acctgcgcca ataactccaa
    11701 cttttttcat gatagtactc tcctctcttc ttacttattt ttattaattc aattatgctt
    11761 ttttagcagc gatgatctca tcctttaaca acggcaagat ttcttttaca tcaccgataa
    11821 atcccatatt tgcaatggag aagatctctg cctgtggatc acggttgata gcgatgatca
    11881 tatctgattt ttccatacca gccacatgct gacatgcacc agaaatacca caagcgatat
    11941 acagagatgg gcgaactgtt tttccagtct gtcctacctg aatagcttta tcaacaaagc
    12001 cgtcatctac gactgcacgt gaagcgcaca tttctccacc taattcttct gcaacggctt
    12061 ttaccatatc taagcagtct tcagcaccac ggccagcagc aaccaagata tctgcttttg
    12121 taatgtcgac accttctact actttttcga ttactttctt tacaacaact tttggatctg
    12181 tatctgtcca ttttggtgag aaagtgacta cttcaccagt tctgcttgca tctggtgcat
    12241 ccattgcaaa cacgtttgga cgaattgtag ccatttgcgg acgagtattt ggacaaatga
    12301 tcgtaccaaa taaattaccg ccaaatgtag gacgtgttac caacaataaa gcttcgccat
    12361 ctgctacttt tgtctgatcc atttcgatct tagtagcatc agctgtcaaa cctgcattta
    12421 aacgtgcagc aacgcgtggt gctaaatcgc gtccaagaac agttgcacct gtcaagaatg
    12481 aatctggttt aaattcattg atgacctgtg tcaaagcatc agcataaaac tgtgtggaat
    12541 agctttctaa taatgcatcg tctacaacga ttactttatc agcaccatgt gcgattactt
    12601 catttgcttt atcagcaatg ttatgtccta acaaaacacc aacaactttg aagcctaagc
    12661 ttggaatgga agcaactaat tttcttgctt cagaaatcag ctcgtaacct acgttggcaa
    12721 tttcgccgtt cttctgttct acaaatacgt aaatgtcttt gtatccttca aatttagcca
    12781 tgtttcttct cctcctattt tgtgatgatc tgcttttctt ttaatgtttt tgcgatcaac
    12841 ttagcagcct ctgcagcagg catatcaaat gtttctgttt ctgctgaaac atccttagta
    12901 aaagtagcat gtacttttgt aggagaacca gctaaaccaa ctaaactttc atcgatgccc
    12961 agatcatcaa aagtaaagat cgtcagttct tttgagaaag aatcaacaat atcgttacag
    13021 ttcatataac gaggctcatt cattccactt aatgtagtca atacacaagg taattttgct
    13081 tcaataattt cttcgcaatc ttccaatgat tttttaacag ttactgtttt gtctgtcaat
    13141 tcaataattt catctacata cgtaacttgt gggataccta aacgctcagc agtctgcgga
    13201 ccaacctgtg ctgtatcgcc atcaattgcc tgacgtccgg caatgatcag atcataaccg
    13261 attttcttta aagcgccggc caaagtagta gatgtagcgc aagtatctgc accaccgaat
    13321 ttacggtcag tgatcaatac acattcatct acgccacgcg cgtataattc tttcaacatg
    13381 tcaccagctt gacctggacc cattgaaaca gcaacaactg ttgctccata tttttctttc
    13441 aactgcaatg cagcctctac accagctaaa tcatctgggt tgatgatact aggaacacca
    13501 gcacggatca acgtaccagt tactttgtct acacggattt ctgttgaatc cggtacttgt
    13561 tttacaagaa cgataatttt catgatcttc gtttcctttc cttctatcta ttattacttc
    13621 agcattgcgc cactgattac catgcgctgt acttccgatg taccttcata gatttctgtg
    13681 atcttagcat cacggaacat tctttctact ggataatcac gagtataacc ataaccaccc
    13741 atcaactgaa ttgcttttgt agttacttcc atagctactt cagcagcaaa taattttgcc
    13801 tttgcagctt ctactgtata aggcatacct ttctcttttt tcattgctgc atcgtaaacc
    13861 aaccaacgag ctgcatctac ttttgtctgc atatcagcta attggaattg tgtattttgg
    13921 aatttagcaa ttgcacgtcc gaactgttta cgtgatttaa cataaggaac gacttcatcg
    13981 attgcgcctt gtgcgatacc taaagcctgt gcagcaatac cgatacggcc accatccaat
    14041 gtcatcatgg caatcttgaa tcccttgcct tcttgtccaa gcaactgatc tttgctcaag
    14101 cgtacattat tgaagatcaa ttcacttgtt gcactaccgc ggatacccaa tttcttttca
    14161 tgttgtccga aagtaaatcc tggcatacct ttttcaacga taaatgcaga aataccatgt
    14221 gtgccttttg atttatctgt cattgcgaag atgatataga catctgcctc accagcattt
    14281 gtgataaaga tttttgtacc gtttaagata taatcttcac catcttttac agctgttgtc
    14341 tgctgacctg cagcatctgt acctgcgttt ggttctgtta aaccaaatgc agctaatttc
    14401 ttgcctgtac aaagatctgg cagatatttt gctttctgct caggtgtacc aaattgagcg
    14461 attggccaag ttcctaaaga tgtgtgtgcg gataaaacaa cacctgttgt accacatttt
    14521 ttgctcaact cttcaactgc aagaatatag cagagatagt cggctccagc tcctccatat
    14581 tcacgagaat atggaatacc cagcattttg catgccttca ttttttcaac agtttctctt
    14641 gggaaacgtt cttcttcgtc gacttcggct gcaagaggtt ttacttcttt ttcagcgaat
    14701 tcagcgaata acttcttcat catttgttgt tgttctgtta acatgaagtc cataatgttc
    14761 tcctccttga ataaatgaac ctagattgtg tgtctgattc accttcacat aatcctttct
    14821 aattttatcc ttttcaatgt aacgcgtcaa ccggtttgtt aaaattttaa caaacaaaaa
    14881 ctcactaaat ttctgattat cttttcataa gctggtaaat gtcggtatag cctgtatttt
    14941 agggctttat cggcattttc ctttgggaag atactctgca taagctggca tttaccagca
    15001 tg
//
