LOCUS       NC_000962.3            22540 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_000962.3 Mycobacterium tuberculosis H37Rv, complete genome.
ACCESSION   NC_000962
VERSION     NC_000962.3
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 00:13:04
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 3695023
            Orig. end    :: 3717563
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..22540
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[3705023:3707563]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..12540
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..22540
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..22540
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="Fumarate2succinate"
                     /region_number="8"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(1447..2163)
                     /locus_tag="ctg1_3445"
                     /transl_table=11
                     /translation="MDGVDRSRGWTHPYQPPFRGPSHDCYIGFNAVQVHVVDHPLAAAR
                     LTTLRDERTDNAGFRAALRELTLLLIYEATRDAPCEPVPIRTPLAETVGSRLTKPPLLV
                     PVLRAGLGMVDEAHAALPEAHVGFVGVARDEQTHQPVPYLDSLPDDLTDVPVMVLDPMV
                     ATGGSMTHTLGLLISRGAADITVLCVVAAPEGIAALQKAAPNVRLFTAAIDEGLNEVAY
                     IVPGLGDAGDRQFGPR"
     CDS             2175..3074
                     /locus_tag="ctg1_3446"
                     /transl_table=11
                     /translation="MLRGIQALSRPLTRVYRALAVIGVLAASLLASWVGAVPQVGLAAS
                     ALPTFAHVVIVVEENRSQAAIIGNKSAPFINSLAANGAMMAQAFAETHPSEPNYLALFA
                     GNTFGLTKNTCPVNGGALPNLGSELLSAGYTFMGFAEDLPAVGSTVCSAGKYARKHVPW
                     VNFSNVPTTLSVPFSAFPKPQNYPGLPTVSFVIPNADNDMHDGSIAQGDAWLNRHLSAY
                     ANWAKTNNSLLVVTWDEDDGSSRNQIPTVFYGAHVRPGTYNETISHYNVLSTLEQIYGL
                     PKTGYATNAPPITDIWGD"
     CDS             3098..4360
                     /locus_tag="ctg1_3447"
                     /transl_table=11
                     /translation="MVADLVPIRLSLSAGDRYTLWAPRWRDAGDEWEAFLGKDDDLYGF
                     ESVSDLVAFVRTDTENDLVDHPAWQDLTGAHAHNLNPAEDNQFDLVVVEELLAEKPTAE
                     SVAALAASLAIVSAIGSVCELAAVSKFFNGNPILGTVSGGLEHFTGKAGNKRWNSIAEV
                     IGRSWDDVLAAIDEIISTPEVDAELSEKVAEELAEEPEGAEEVAAEVEATQDTQEAAES
                     DDEEADAPGDSVVLGGDRDFWLQVGIDPIQIMTGTATFYTLRCYLDDRPIFLGRNGRIS
                     VFGSERALARYLADEHDHDLSDLSTYDDIRTAATDGSLAVAVTDDNVYVLSGLVDDFAD
                     GPDAVDREQLDLAVELLRDIGDYSEDSAVDKALETTRPLGQLVAYVLDPHSVGKPTAPY
                     AAAVREWEKLERFVESRLRRE"
     CDS             complement(4381..5313)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_3448"
                     /sec_met_domain="Abhydrolase_1 (E-value: 3.7e-10, bitscore:
                     37.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VLLTGPPPSLPERIRTDEADVLMLPDGRALAYLEWGDSTGYPAFY
                     FHGTPSSRLEGAFADGAARRTGFRLIAIDRPGYGRSTFQAGRNFRDWPADVCALADAFE
                     LEEFGVVGHSGAGPHLFACGAVIPRTRLAFVGALGPWGPLATPDIMRSLNAADRCYARL
                     ARSGPRLFGALFAPLGWCAKYTPGLFSTLLAAAVPAADKHLLSDERFGRHLRAIQLEAF
                     RQGSRGAAYESFLQFRPWGFDLAEVAVPTHIWLGDRDSFVPRAMGEYLQRAIPHVDLHW
                     AHGKGHFNIEDWDAILAACALDIGKRRGG"
     CDS             complement(5333..5503)
                     /locus_tag="ctg1_3449"
                     /transl_table=11
                     /translation="MNGDSASTIDIDKAVTRTPVRRIVRSALDRLWLRQSQPRRYRFLE
                     DSCMARALNRL"
     CDS             complement(5682..5993)
                     /locus_tag="ctg1_3450"
                     /transl_table=11
                     /translation="MYRFACRTLMLAACILATGVAGLGVGAQSAAQTAPVPDYYWCPGQ
                     PFDPAWGPNWDPYTCHDDFHRDSDGPDHSRDYPGPILEGPVLDDPGAAPPPPAAGGGA"
     CDS             complement(6064..7161)
                     /locus_tag="ctg1_3451"
                     /transl_table=11
                     /translation="MTAAPTLQTIRLAPKALLHDHLDGGLRPATVLDIAGQVGYDDLPA
                     TDVDALASWFRTQSHSGSLERYLEPFSHTVAVMQTPEALYRVAFECAQDLAADSVVYAE
                     VRFAPELHISCGLSFDDVVDTVLTGFAAGEKACAADGQPITVRCLVTAMRHAAMSREIA
                     ELAIRFRDKGVVGFDIAGAEAGHPPTRHLDAFEYMRDHNARFTIHAGEAFGLPSIHEAI
                     AFCGADRLGHGVRIVDDIDVDADGGFQLGRLAAILRDKRIPLELCPSSNVQTGAVASIA
                     EHPFDLLARARFRVTVNTDNRLMSDTSMSLEMHRLVEAFGYGWSDLARFTVNAMKSAFI
                     PFDQRLAIIDEVIKPRFAALMGHSE"
     CDS             complement(7161..8444)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_trans_3N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_3452"
                     /sec_met_domain="Glycos_trans_3N (E-value: 1.6e-17,
                     bitscore: 61.0, seeds: 1422, tool: rule-based-clusters)"
                     /sec_met_domain="Glycos_transf_3 (E-value: 3.7e-33,
                     bitscore: 113.1, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VTDFAFDAPTVIRTKRDGGRLSDAAIDWVVKAYTDGRVADEQMSA
                     LLMAIVWRGMDRGEIARWTAAMLASGARLDFTDLPLATVDKHSTGGVGDKITLPLVPVV
                     AACGGAVPQASGRGLGHTGGTLDKLESITGFTANLSNQRVREQLCDVGAAIFAAGQLAP
                     ADAKLYALRDITGTVESLPLIASSIMSKKLAEGAGALVLDVKVGSGAFMRSPVQARELA
                     HTMVELGAAHGVPTRALLTEMNCPLGRTVGNALEVAEALEVLAGGGPPDVVELTLRLAG
                     EMLELAGIHGRDPAQTLRDGTAMDRFRRLVAAQGGDLSKPLPIGSHSETVTAGASGTMG
                     DIDAMAVGLAAWRLGAGRSRPGARVQHGAGVRIHRRPGEPVVVGEPLFTLYTNAPERFG
                     AARAELAGGWSIRDSPPQVRPLIVDRIV"
     misc_feature    complement(7398..7400)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="gutsmash"
     CDS             complement(8441..8842)
                     /locus_tag="ctg1_3453"
                     /transl_table=11
                     /translation="MPDVDWNMLRGNATQAAAGAYVPYSRFAVGAAALVDDGRVVTGCN
                     VENVSYGLTLCAECAVVCALHSTGGGRLLALACVDGHGSVLMPCGRCRQVLLEHGGSEL
                     LIDHPVRPRRLGDLLPDAFGLDDLPRERR"
     CDS             9079..9417
                     /locus_tag="ctg1_3454"
                     /transl_table=11
                     /translation="MWSWVCHRISGATIFFFLFVHVLDAAMLRVSPQTYNAVLATYKTP
                     IVGLMEYGLVAAVLFHALNGIRVILIDFWSEGPRYQRLMLWIIGSVFLLLMVPAGVVVG
                     IHMWEHFR"
     CDS             9414..9848
                     /locus_tag="ctg1_3455"
                     /transl_table=11
                     /translation="MSAPVRQRSHDRPASLDNPRSPRRRAGMPNFEKFAWLFMRFSGVV
                     LVFLAIGHVFIMLMWDNGVYRLDFNFVAQRWASPFWQTWDLLLLWLAQLHGGNGLRTII
                     DDYSRKDTTRFWLNSLLVLSMLFTLMLGTYVIVTFDPNIS"
     CDS             10001..11749
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 366.2; E-value:
                     8.3e-112)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_3456"
                     /sec_met_domain="FAD_binding_2 (E-value: 5.5e-110,
                     bitscore: 366.2, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 4.3e-44,
                     bitscore: 147.5, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGAAQGGMCA
                     ALANVEDDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRI
                     DQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFNEFYALDLALTQ
                     TPSGPVATGVIAYELATGDIHVFHAKAVVIATGGSGRMYKTTSNAHTLTGDGIGIVFRK
                     GLPLEDMEFHQFHPTGLAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDI
                     VARSMVLEVLEGRGAGPLKDYVYIDVRHLGEEVLEAKLPDITEFARTYLGVDPVTELVP
                     VYPTCHYLMGGIPTTVTGQVLRDNTSVVPGLYAAGECACVSVHGANRLGTNSLLDINVF
                     GRRAGIAAASYAQGHDFVDMPPNPEAMVVGWVSDILSEHGNERVADIRGALQQSMDNNA
                     AVFRTEETLKQALTDIHALKERYSRITVHDKGKRFNTDLLEAIELGFLLELAEVTVVGA
                     LNRKESRGGHAREDYPNRDDVNYMRHTMAYKEIGADKEGPELRSDVRLDFKPVVQTRYE
                     PKERKY"
     misc_feature    10733..10735
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="gutsmash"
     misc_feature    11516..11518
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="gutsmash"
     CDS             11749..12540
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_3457"
                     /sec_met_domain="Fer2_3 (E-value: 3.5e-30, bitscore: 102.1,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 1.5e-11, bitscore: 42.5,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.13, bitscore: 10.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVEPDVETLDPPLPPVPDGAVMVTVKIARFNPDDPDAFAATGGW
                     QSFRVPCLPSDRLLNLLIYIKGYLDGTLTFRRSCAHGVCGSDAMRINGVNRLACKVLMR
                     DLLPKKKGKSLTVTVEPIRGLPVEKDLVVDMEPFFDAYRAIKPYLITSGNPPTRERIQS
                     PTDRARYDDTTKCILCACCTTSCPVFWHEGSYFGPAAIVNAHRFIFDSRDEAAAERLDI
                     LNEVDGVWRCRTTFNCTESCPRGIEVTKAIQEVKRALMFTR"
     CDS             complement(12619..13047)
                     /locus_tag="ctg1_3458"
                     /transl_table=11
                     /translation="MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNG
                     FVRVISQPRYPSPISVAHAIDLLARATHTRYHEFWSCTVSILDSKVIDRSRLHSPKQVT
                     DAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL"
     CDS             complement(13051..13293)
                     /locus_tag="ctg1_3459"
                     /transl_table=11
                     /translation="MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQP
                     AASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV"
     misc_feature    complement(13180..13182)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="gutsmash"
     CDS             complement(13415..14029)
                     /locus_tag="ctg1_3460"
                     /transl_table=11
                     /translation="MSVQTDPALREHPNRVDWNARYERAGSAHAPFAPVPWLADVLRAG
                     VPDGPVLELASGRSGTALALAAHGRQVTAIDVSDVALLQLDSEAVRRGVADRLNLVQAD
                     LGCWEPGETRFALVLSRLFWDAAIFHRACEAVMPGGVLAWESLALSGAEAGTASAKRRV
                     KPGEPACLLPADFTVVHEGQGNCDSAPSRIMIARRSPLPGA"
     misc_feature    complement(13868..13870)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="gutsmash"
     CDS             complement(14026..14691)
                     /locus_tag="ctg1_3461"
                     /transl_table=11
                     /translation="MITVNVLYFGAVREACKVAHEKISLESGTTVDGLVDQLQIDYPPL
                     ADFRKRVRMAVNESIAPASTILDDGDTVAFIPQVAGGSDVYCRLTDEPLSVDEVLNAIS
                     GPSQGGAVIFVGTVRNNNNGHEVTKLYYEAYPAMVHRTLMDIIEECERQADGVRVAVAH
                     RTGELRIGDAAVVIGASAPHRAAAFDAARMCIERLKQDVPIWKKEFALDGVEWVANRP"
     misc_feature    complement(14590..14592)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="gutsmash"
     CDS             complement(14692..15225)
                     /locus_tag="ctg1_3462"
                     /transl_table=11
                     /translation="VNDHDGVLTHLDEQGAARMVDVSAKAVTLRRARASGAVLMKPSTL
                     DMICHGTAAKGDVIATARIAGIMAAKRTGELIPLCHPLGIEAVTVTLEPQGADRLSIAA
                     TVTTVARTGVEMEALTAVTVTALTVYDMCKAVDRAMTITDIRLDEKSGGRSGHYRRHDA
                     DVKPSDGGSTEDGC"
     CDS             complement(15222..15374)
                     /locus_tag="ctg1_3463"
                     /transl_table=11
                     /translation="MPGRFSVHNKRSVRLTCWTRQMHCLTRVDFDLAEAFSAVHDEQCS
                     QQVAR"
     CDS             15410..15736
                     /locus_tag="ctg1_3464"
                     /transl_table=11
                     /translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGVG
                     CAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAELD
                     RPAR"
     misc_feature    15683..15685
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="gutsmash"
     CDS             15787..16671
                     /locus_tag="ctg1_3465"
                     /transl_table=11
                     /translation="LRWGVESICTQLTELGVPIAPSTYYDHINREPSRRELRDGELKEH
                     ISRVHAANYGVYGARKVWLTLNREGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPA
                     TARPADLVQRRFGPPAPNRLWVADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMAT
                     SMVLDAIEQAIWTRQQEGVLDLKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSS
                     YDNALAETINGLYKTELIKPGKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELE
                     AAYYAQRQRPAAG"
     CDS             16726..18438
                     /locus_tag="ctg1_3466"
                     /transl_table=11
                     /translation="MVVVGTDAHKYSHTFVATDEVGRQLGEKTVKATTAGHATAIMWAR
                     EQFGLELIWGIEDCRNMSARLERDLLAAGQQVVRVPTKLMAQTRKSARSRGKSDPIDAL
                     AVARAVLRETDLPLATHDETSRELKLLTDRRDVLVAQRTSAINRLRWLVHELDPERAPA
                     ARSLDAAKHQQALRTWLDTQPGLVAELARAELTDIIRLTGEINTLAQRISARVHQVAPA
                     LLEIPGCAELTAAKIVGEAAGVTRFKSEAAFACHAAVAPIPVWSGNTAGQMRLSRSGNR
                     QLNAALHRIALTQIRMTDSRGQAYYQRLQDAGKTKRAALRCLKRRLARTVFQALRTVHQ
                     PSSEHTQPAAACHRSYCSSHLGEPPRLTDMTQKTRIQPLPPKRAGLLIRALYRIAKRRF
                     GEVPEPFTVTAHHRRLLIANVVHEALLQRASRKLPPSVRELAVFWTARSIGCSWCVDFG
                     AMLQRLDGLDVDRLTDIDNYATSSKFSDDERAAIAYAEAMTADPHSVTDEQVADLRARF
                     GEAGVIELTYQIGVENMRARMNSALGITEQGFNSGDACRVPWAAPDVPSAESR"
     CDS             complement(18371..19318)
                     /locus_tag="ctg1_3467"
                     /transl_table=11
                     /translation="MTSMEVSEFEALRQHLMSVAYRLTGTVADAEDIVQEAWLRWDSPD
                     TVIADPRAWLTTVVSRLGLDKLRSAAHRRETYTGTWLPEPVVTGLDATDPLAAVVAAED
                     ARFAAMVVLERLRPDQRVAFVLHDGFAVPFAEVAEVLGTSEAAARQLASRARKAVTAQP
                     ALISGDPDPAHNEVVGRLMAAMAAGDLDTVVSLLHPDVTFTGDSNGKAPTAVRAVRGSD
                     KVVRFILGLVQRYGPGLFGANQLALVNGELGAYTAGLPGVDGYRAMAPRITAITVRDGK
                     VCALWDIANPDKFTGSPLKERRAQPTGRGRHHRN"
     misc_feature    complement(18542..18544)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="gutsmash"
     CDS             19369..20685
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_3468"
                     /sec_met_domain="Aminotran_3 (E-value: 3.6e-94, bitscore:
                     313.6, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LHFARHGAGIQHPVIVRGDGVTIFDDRGKSYLDALSGLFVVQVGY
                     GRAELAEAAARQAGTLGYFPLWGYATPPAIELAERLARYAPGDLNRVFFTSGGTEAVET
                     AWKVAKQYFKLTGKPGKQKVISRSIAYHGTTQGALAITGLPLFKAPFEPLTPGGFRVPN
                     TNFYRAPLHTDLKEFGRWAADRIAEAIEFEGPDTVAAVFLEPVQNAGGCIPAPPGYFER
                     VREICDRYDVLLVSDEVICAFGRIGSMFACEDLGYVPDMITCAKGLTSGYSPLGAMIAS
                     DRLFEPFNDGETMFAHGYTFGGHPVSAAVGLANLDIFEREGLSDHVKRNSPALRATLEK
                     LYDLPIVGDIRGEGYFFGIELVKDQATKQTFTDDERARLLGQVSAALFEAGLYCRTDDR
                     GDPVVQVAPPLISGQPEFDTIETILRSVLTDTGRKYLHL"
     CDS             20754..21971
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S11"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_3469"
                     /sec_met_domain="Peptidase_S11 (E-value: 2.1e-36, bitscore:
                     123.5, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAFLRSVSCLAAAVFAVGTGIGLPTAAGEPNAAPAACPYKVSTPP
                     AVDSSEVPAAGEPPLPLVVPPTPVGGNALGGCGIITAPGSAPAPGDVSAEAWLVADLDS
                     GAVIAARDPHGRHRPASVIKVLVAMASINTLTLNKSVAGTADDAAVEGTKVGVNTGGTY
                     TVNQLLHGLLMHSGNDAAYALARQLGGMPAALEKINLLAAKLGGRDTRVATPSGLDGPG
                     MSTSAYDIGLFYRYAWQNPVFADIVATRTFDFPGHGDHPGYELENDNQLLYNYPGALGG
                     KTGYTDDAGQTFVGAANRDGRRLMTVLLHGTRQPIPPWEQAAHLLDYGFNTPAGTQIGT
                     LIEPDPSLMSTDRNPADRQRVDPQAAARISAADALPVRVGVAVIGALIVFGLIMVARAM
                     NRRPQH"
     misc_feature    20763..20765
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="gutsmash"
ORIGIN
        1 acctggcggt ggtgttgcgc gccacctggg cggtggcacg ggtgctcacg gatcgaggtc
       61 tggctggttc gccggtgatc gtggggcgcg acgctcggca cggctcaccg gcgtttgccg
      121 ctgcggccgc cgaagtgctt gccgccgcag gtttttccgt gctgcttctg cccgatcccg
      181 cacccacccc ggtggtggcg ttcgcggtgc ggcacaccgg cgccgccgct gggatacaga
      241 tcacggcgtc acacaacccg gcgaccgaca acggctacaa ggtctatgtc gacggcggcc
      301 ttcagctcct cgcccctacc gaccggcaga tcgaagccgc gatggccacc gcgcccccgg
      361 ccgatcagat cgccaggaag accgtcaacc ccagtgaaaa ccgcgcctcc gatctgatcg
      421 accgttatat ccagcgtgcg gccggggtcc gaaggtgcgc cggttcggtc cgggtggccc
      481 tgacgccgct gcacggggtt ggcggggcga tggccgtcga gacccttcgg cgagccggtt
      541 tcaccgaggt gcataccgtg gcgacgcaat tcgcgccgaa tcccgacttc cccaccgtga
      601 cattgccgaa ccccgaggag cccggagcca ccgacgcact gctcaccctg gctaccgacg
      661 tggacgccga cgtcgcgatc gcgctggatc ccgatgcgga tcgctgcgcg gtcgggatac
      721 ccacggtgtc gggatggcgg atgctgtccg gtgacgaaac cggttggcta ctaggtgatt
      781 acatcttgtc gcaaaccgac gaccgggcgt cgccgccgga aaccagggtg gtggccagca
      841 ccgtggtgtc gtcgcggatg ctggcggcga tcgccgcgca tcacgctgcc gtgcacgtgg
      901 agaccctcac cggctttaag tggctggcgc gcgccgatgc gaacctgccc ggcaccctgg
      961 tgtacgccta cgaggaagcg atcgggcact gcgtcgaccc caccgcggtg cgtgacaaag
     1021 acggcatcag cgccgcggtg ttggtgtgcg atctggtggc cgcgctcaaa ggccagggtc
     1081 gttcggtgac cgacgcgctc gacgagctcg cccgatgcta cggcgtgcat gaggttgccg
     1141 ccctgtcacg ccccgtgagc ggcgccgtcg agaccaccga cctgatgcga cggctccgcg
     1201 aggacccgcc gcgtcggctg gccggtttcc ccgccacggt caccgatatc ggcgacacgc
     1261 tgatcctcac cggcggcgac gacaacatgt tggtcagggt ggcggtgcgg ccttctggaa
     1321 cagaaccgaa gctgaagtgc tacttggaga ttcgctgcgc ggtgaccggt gacctaccag
     1381 ctgcccgaca gctggtgcgg gcgaggatcg atgagctgtc ggctagcgtg cggcggtggt
     1441 ggtgactcag cgcgggccga actggcgatc gccggcatcg ccgagaccgg gcacaatgta
     1501 ggcgacctcg ttaagccctt cgtcgatggc cgcagtgaac aaccgcacgt ttggcgcagc
     1561 cttctgcagc gccgcgattc cttctggcgc cgcaaccaca cacagcaccg tgatatccgc
     1621 tgcaccgcgc gagatcagca gaccgagggt gtgcgtcatc gacccgccgg tggccaccat
     1681 cgggtcaagc accatgaccg gtacatccgt caggtcgtcg ggcagcgagt ccagatacgg
     1741 caccggctgg tgggtttgct cgtcgcgggc gacaccgaca aagccaacgt gcgcctccgg
     1801 caaggcggca tgcgcctcgt cgaccatccc caaccccgcc cgcaacacag gaaccagcag
     1861 gggtggcttg gttagccgcg acccgaccgt ctcggccagc ggcgtacgga tcgggactgg
     1921 ctcgcagggc gcatcgcggg tggcctcata gatcaacagc agcgtgagct cgcgcagcgc
     1981 tgcccggaag ccggcgttgt cggtgcgttc gtcacgcagc gtggtcagtc gggccgcggc
     2041 cagtgggtgg tcaacgacat ggacctgcac ggcgttgaac cctatataac aatcgtggct
     2101 cggtccccta aaagggggct gatacgggtg cgtccatccg cgcgaccggt caaccccgtc
     2161 catatactcc cggcatgctc cgcggaatcc aggctctcag ccggcccctg accagggtat
     2221 accgtgcctt ggcggtgatc ggtgtcctgg cagcatcgtt gctggcctca tgggtcggcg
     2281 ctgtcccaca agtgggtctg gcagcgagtg ccctgccgac cttcgcgcac gtggtcatcg
     2341 tggtggagga gaaccgctcg caggccgcca tcatcggtaa caagtcggct cccttcatca
     2401 attcgctggc cgccaacggc gcgatgatgg cccaggcgtt cgccgaaaca cacccgagcg
     2461 aaccgaacta cctggcactg ttcgctggca acacattcgg gttgacgaag aacacctgcc
     2521 ccgtcaacgg cggcgcgctg cccaacctgg gttctgagtt gctcagcgcc ggttacacat
     2581 tcatggggtt cgccgaagac ttgcctgcgg tcggctccac ggtgtgcagt gcgggcaaat
     2641 acgcacgcaa acacgtgccg tgggtcaact tcagtaacgt gccgacgaca ctgtcggtgc
     2701 cgttttcggc atttccgaag ccgcagaatt accccggcct gccgacggtg tcgtttgtca
     2761 tccctaacgc cgacaacgac atgcacgacg gctcgatcgc ccaaggcgac gcctggctga
     2821 accgccacct gtcggcatat gccaactggg ccaagacaaa caacagcctg ctcgttgtga
     2881 cctgggacga agacgacggc agcagccgca atcagatccc gacggtgttc tacggcgcgc
     2941 acgtgcggcc cggaacttac aacgagacca tcagccacta caacgtgctg tccacattgg
     3001 agcagatcta cggactgccc aagacgggtt atgcgaccaa tgctccgcca ataaccgata
     3061 tttggggcga ctagccgccg tcgctattct gtgccgcatg gttgctgacc tcgtacccat
     3121 ccgcttgagc ctgtccgctg gtgaccgcta cacgctgtgg gctcctcgct ggcgggatgc
     3181 cggcgacgag tgggaggcgt tcctgggcaa agacgacgac ctgtatggct tcgagagcgt
     3241 ctctgacctg gtcgcgttcg tgcgcaccga caccgagaac gacctggtcg accacccggc
     3301 atggcaagac ctgaccggag cccacgcgca caacctcaat ccggccgaag acaatcagtt
     3361 cgacctggtc gtcgtcgagg aactgctggc tgagaagccg acggcggagt cagtggccgc
     3421 gctggccgcc tcattggcga tcgtatccgc catcggatcg gtgtgcgaac tggcggcagt
     3481 gtcgaagttc ttcaacggca atcccatcct gggcacggtt tccggcgggc tcgaacactt
     3541 caccggaaaa gccggcaata aacgctggaa ttcgattgcc gaggtcatcg gacgcagctg
     3601 ggacgacgtg ctcgcggcca tcgacgagat catcagcacc cccgaggtcg acgctgagct
     3661 gtcggaaaag gtcgccgagg agttggcgga ggagcccgag ggcgccgagg aagtggcggc
     3721 ggaggtggag gccacgcagg acacgcagga ggcggccgag tccgacgacg aggaagccga
     3781 cgcacccggt gacagtgtcg tactgggcgg cgatcgggac ttctggttgc aggtgggcat
     3841 cgacccgatc cagatcatga cgggcaccgc caccttctac acgcttcgct gttacctgga
     3901 tgatcgaccg atcttcctgg gccgcaatgg tcggatcagt gtgtttggct ccgagcgggc
     3961 attggcccgc tatcttgccg atgagcacga ccacgacttg tcggacctga gcacctacga
     4021 cgacatccgc acggccgcca ccgacggctc gctggcggtt gccgttaccg acgacaacgt
     4081 ctatgtgctc agtgggctgg tcgacgattt tgccgacggg ccggacgcgg tggaccgtga
     4141 gcagctcgac ctggccgtcg agctgctccg cgatatcggc gactactccg aggacagcgc
     4201 agtcgacaag gcactcgaga caacccgccc gctgggccag ctggtggcct atgtgttgga
     4261 cccccactcg gtcggcaaac ccacggcccc gtatgcggcg gctgtccgtg aatgggagaa
     4321 attggaaagg ttcgtggagt cgcggctcag gcgcgaatag gcaccgtcag ccggcgaagg
     4381 ctagccgccg cggcgcttgc cgatgtccag ggcacacgcg gcgaggatcg catcccagtc
     4441 ttcgatgttg aaatggccct tgccgtgcgc ccagtgcaaa tcaacgtgcg gaatcgcgcg
     4501 ctgcaggtat tcgcccatgg cgcgtggcac gaaggagtca cgatcaccca gccagatatg
     4561 ggtaggcacg gccacctcgg cgaggtcgaa accccacggc cgaaattgca gaaatgattc
     4621 ataggctgcg ccgcggctgc cctgtcggaa cgcttcgagc tggatggcgc gcaggtggcg
     4681 gccgaagcgt tcgtcgctca gcaggtgctt gtcggccgcg gggaccgcag ccgccaacaa
     4741 cgtagaaaac agcccgggcg tgtatttcgc gcaccagccg agcggggcaa acaacgcacc
     4801 gaatagccgc ggcccgcttc gcgccaaccg cgcgtagcac cgatcggccg cgttgaggct
     4861 gcgcatgata tccggcgtcg ccagtggacc ccatggtccg agcgcgccga cgaacgctag
     4921 tcgggtccgc gggatgacgg caccgcaggc gaataggtgc ggtcccgcgc ccgaatgccc
     4981 gaccaccccg aactcctcca gctcgaacgc gtcagccagg gcacacacgt ccgcgggcca
     5041 atcgcgaaaa ttgcgtcccg cttgaaaggt ggagcgcccg tacccgggcc gatcaatcgc
     5101 tatcagtcgg aagccggtgc gccgcgcggc accatcggcg aaggccccct cgagccgcga
     5161 acttggcgtg ccgtggaagt agaacgctgg gtagccggtg ctatcacccc attccaggta
     5221 ggcaagcgcc cgcccgtcgg gcagcatgag cacatccgcc tcgtcggtgc gaatgcgctc
     5281 gggcagcgat ggcggtggcc cggtcaagag cacaccagcg atggtatgcc gatcagagtc
     5341 gattcagcgc gcgtgccatg cacgagtcct cgaggaaccg atagcgccta ggctgggact
     5401 gccgcaacca cagccgatcc agcgccgaac gcacgatccg gcgaacgggt gtgcgggtaa
     5461 cagccttgtc gatgtcgatg gtggaggcgc tgtcgccgtt catgacaggt tcccttcaag
     5521 cgtcctgcaa gcggttgcca aagccgtcgc ctattttctg tcatcggacg gcgcgatcca
     5581 tcggcacggg agcgtaaatc tgccccgccg ggggtcgtag cttgccgggg gcacgcccgg
     5641 gtttatacgc gtattcgctg atgcggcccg gtcaacgagc gctatgcgcc gccaccggca
     5701 gccgggggcg gcggcgcagc accgggatcg tcaagcacgg gaccttcgag gatgggtccg
     5761 gggtagtcgc ggctgtggtc ggggccgtcg ctgtcgcggt ggaagtcgtc atggcaggtg
     5821 tagggatccc agttgggccc ccatgcgggg tcgaaaggct gccccgggca ccagtagtag
     5881 tcgggcaccg gcgcggtttg ggctgcggac tgcgcgccga ccccgagacc cgccacaccc
     5941 gtggccagga tgcacgccgc cagcatgagc gtgcggcacg cgaaccggta catgcgatga
     6001 cggtacgaaa gcgatctggc aagcaactgg acgctaggtg cgatatacca gagaacttgc
     6061 tgattactcg ctgtgaccca tgagcgccgc gaaccgcggc ttgatcactt cgtcgattat
     6121 cgccagccgc tggtcgaacg gaatgaacgc ggatttcatc gcattgacgg tgaagcgcgc
     6181 caggtcgctc cagccataac cgaaagcctc taccaaacga tgcatttcga ggctcatcga
     6241 ggtgtcgctc atcagccggt tgtcggtatt gacggtcacc cggaaccggg cccgagccag
     6301 taggtcgaac ggatgctcgg cgatgcttgc gaccgcgccg gtctgcacgt tggagctggg
     6361 gcacagctcc agcggaattc gcttgtcccg caggatagct gccagccgac ccaactggaa
     6421 accgccgtcg gcatccacgt cgatgtcgtc gacgatccgc accccgtgac ccagccggtc
     6481 ggcaccgcag aaggcgatcg cctcgtggat ggacggcaac ccgaacgcct caccggcatg
     6541 aatcgtgaag cgcgcgttgt gatcacgcat gtactcgaat gcatccaagt gccgggttgg
     6601 cgggtggccg gcctccgcgc cggcgatgtc gaatccgaca actcccttgt cccggaaccg
     6661 gatcgccaac tctgcgatct cccgggacat tgcggcgtgc cgcatcgcgg tgaccagaca
     6721 gcggacggtg atgggttgac catcggcggc acacgccttc tcgccggcgg cgaagcccgt
     6781 cagaacggtg tcgacgacgt cgtcgaacga cagcccgcag ctgatgtgca gctccggcgc
     6841 gaaccgcacc tcggcataga ccaccgaatc ggcggccagg tcttgcgcgc attcgaaggc
     6901 gacccgatac aaggcctcgg gagtctgcat caccgccacc gtgtgcgaaa acggttccag
     6961 gtagcgctcc agcgagccgc tgtgcgactg ggtgcgaaac caacttgcca gcgcgtcgac
     7021 gtcagttgcc ggcaggtcgt cgtatccgac ctgcccggca atgtccagca cggtggccgg
     7081 ccgcagcccg ccgtcgaggt gatcgtgcag caacgccttg ggggctagcc tgatcgtctg
     7141 cagggtcggc gcagcggtca tcagacgatc cgatcgacga ttagcggccg cacctgcggc
     7201 ggactgtccc ggatactcca accgccggcc agctcggctc gcgccgcacc aaagcgctcg
     7261 ggagcattcg tgtagagggt gaacaacggc tcaccgacca caaccggctc ccccgggcgg
     7321 cgatgaatcc gcacccccgc accgtgctgt acgcgtgcgc ccgggcggga cctgcccgca
     7381 ccgagtcgcc atgccgctaa ccccactgcc atcgcatcga tgtcgcccat tgtgccgctc
     7441 gcgcccgccg tgacggtttc cgaatgcgaa ccgatcggca acggtttcga caagtcacct
     7501 ccctgcgcgg caaccaaccg gcgaaaccgg tccattgcgg tgccgtcccg cagcgtctgg
     7561 gccgggtccc ggccgtggat cccggcaagc tcgagcatct cgccggccag ccgcaacgtc
     7621 agctccacca cgtcgggcgg tccgccgccg gccagcacct ccagcgcctc ggccacctcg
     7681 agcgcattgc cgacggttcg acccagcggg cagttcatct ccgtcagcag ggcacgggtg
     7741 ggcacgccat gcgccgcgcc cagttcgacc atggtgtgcg caagttcgcg cgcctgcact
     7801 ggcgacctca tgaaggcccc ggaaccaacc ttgacgtcga gcaccagtgc acccgcaccc
     7861 tcagccagct tcttgctcat aatcgaactg gcgatcaacg gcagcgattc gacggtgccg
     7921 gtaatgtcgc gcagcgcata cagcttggca tcggctggcg ccagctggcc ggcggcgaag
     7981 atcgcggcgc cgacgtcgca aagctgctcg cgcacccgct ggttggacag attcgcggtg
     8041 aacccggtga tggattccag cttgtccagg gtgccgccgg tgtggccgag tccgcggccc
     8101 gacgcctggg gcactgcgcc accgcaggcg gcgacgacgg gcaccaatgg cagcgtgatt
     8161 ttgtcaccta ccccgccggt ggaatgcttg tccacggtcg ctagtggcag atcggtgaaa
     8221 tccagccggg cacccgaggc cagcatggcc gccgtccatc tggcgatctc gccgcggtcc
     8281 atgccccgcc aaacgatcgc catcagcagc gccgacatct gttcgtcggc gacccggccg
     8341 tcggtatagg ccttgacgac ccagtcgatg gcggcgtcgg acaaccggcc gccgtcacgt
     8401 ttggtgcgga tgacggtcgg ggcgtcgaat gcgaagtcgg tcaccggcgt tcccggggga
     8461 ggtcgtcgag gccgaaggcg tcgggcagca ggtcgccgag ccggcggggt cgcaccggat
     8521 ggtcgatcag tagctcggaa cccccgtgtt cgagcagcac ctgacggcat cgcccgcacg
     8581 gcatcagcac ggatccatgg ccgtcgacgc aggccagcgc gagcagccgg ccgccgccgg
     8641 tcgaatgcag ggcgcacacc accgcacatt cggcgcacaa agtcaagcca tacgagacgt
     8701 tttccacgtt gcatccggtc accacgcgac catcgtcgac cagtgcggcc gcacccaccg
     8761 caaaccgcga atacggcaca taggctccgg ctgctgcctg ggttgcattg ccccgcagca
     8821 tattccaatc gacatcaggc attcggcaac cccgctcgtc gatgggccga ctaagaaaag
     8881 ccagcctaac cccggatcca cacacgatcc cgatcggact gttcgacacc gcgggcaacc
     8941 tggccaagtt aagctcgatt gcccggctct agctgttcga tagtgctttt aaggggtttg
     9001 ccagcggtga atacaacggc gacaaccgtc tcgcgcgggc ggcggccacc tcggaccctg
     9061 tatcggggag atcccggtat gtggtcgtgg gtatgccatc gcatcagcgg cgcgacgatt
     9121 ttcttcttcc tgtttgtcca tgtcctggac gccgccatgc tgcgggtgag cccgcagacc
     9181 tacaacgcgg tgctggcgac ctacaagacc ccgatcgtcg gcctgatgga gtacggccta
     9241 gtcgccgcgg tcctttttca cgcactgaac gggattcggg tcatcttgat cgatttctgg
     9301 tcggaaggcc cgcgctatca gcggctgatg ttgtggatca tcggcagcgt cttcctcttg
     9361 ctgatggttc cggcaggcgt ggtggtgggc atccacatgt gggagcactt ccgatgagcg
     9421 ccccggtcag acagcgcagc catgaccgtc cagccagcct ggacaaccca cgatcaccac
     9481 ggcggcgtgc cggcatgccc aacttcgaga aattcgcctg gctgttcatg cggttttccg
     9541 gtgttgtgtt ggtgttcctg gcgatcgggc acgtgttcat catgctgatg tgggacaacg
     9601 gcgtgtatcg cctggacttc aacttcgttg cccaacgctg ggcgtcgccg ttctggcaga
     9661 cctgggatct gctgttgttg tggctggcgc agctgcacgg cggcaacggt ctgcgcacca
     9721 tcattgacga ctacagccgc aaagacacca cccgattctg gctgaactcg ttgctggtgt
     9781 tgtccatgct gttcaccctg atgctgggaa cctacgtgat agtgacattc gacccgaaca
     9841 tctcctgaaa ggcccggaag gagcacatga tcacgccacc tctcccccgc aagcgggcgg
     9901 tacccccacc tcatcgctgc ggccccctcg tcgcttcgcg gctgggggtg cccccactgc
     9961 atcgtcggcg gcggcgttga tctgccaaca ccgatacgac gtggtgatcg tcggcgcggg
    10021 cggtgccggg atgcgcgccg cggtcgaggc gggtccgcgg gtgcgtaccg cggtgctgac
    10081 caagctgtat cccacccgca gccacaccgg cgcggcccag ggcggcatgt gcgccgcgct
    10141 ggccaacgtc gaggacgaca actgggagtg gcacacgttc gacaccgtca agggcggcga
    10201 ctatctcgcc gaccaggacg ccgtggagat catgtgcaag gaagccatcg acgcggtgct
    10261 cgacctggag aagatgggga tgccgttcaa ccgcaccccc gagggccgca tcgaccagcg
    10321 ccgcttcggc gggcacaccc gcgaccacgg caaggccccg gtgcgccggg cctgctacgc
    10381 ggccgatcgc accggccaca tgattctgca gacgctgtat cagaactgcg tcaagcacga
    10441 cgtcgagttc ttcaacgagt tttacgcgct ggatttggct ttgactcaaa cgccgtcggg
    10501 cccggtggcc accggggtga tcgcctacga gctagcgacc ggtgacatcc atgtctttca
    10561 cgccaaggcc gtcgtgatcg cgaccggcgg ctcgggccgc atgtataaga ccacgtccaa
    10621 cgcacacacc ctgaccggcg acggcatcgg catcgtgttc cgcaagggac ttcccttgga
    10681 ggacatggag tttcaccagt ttcaccctac cggcctggcc ggtctgggca tcttaatctc
    10741 cgaagcggtg cgcggcgaag gcggccggct gctcaacggg gaaggtgagc gtttcatgga
    10801 gcgctacgcc ccgacgatcg tcgacctagc gccccgcgac atcgtcgccc gctcgatggt
    10861 gctggaagtg ctggagggac gcggcgccgg accgctcaag gactacgtct acatcgacgt
    10921 ccgccacctg ggcgaggaag tgctcgaggc caagctgccc gacatcaccg agttcgcccg
    10981 cacctacctg ggcgtggatc cggtcaccga gctggtgccg gtctacccga cgtgccacta
    11041 cctgatgggc ggcatcccga ccacagtcac cgggcaggtg ctgcgggaca acaccagcgt
    11101 tgtcccgggc ctgtatgcgg ccggcgagtg cgcgtgcgtg tcggtgcatg gcgccaaccg
    11161 gctgggcacc aactcgctgt tggatatcaa cgtcttcggt cgtcgggccg gcatcgccgc
    11221 cgccagttat gcgcagggtc acgactttgt cgacatgccg cccaacccgg aggccatggt
    11281 ggtgggctgg gtcagcgaca tcctgtccga acacggaaac gagcgggtcg ccgacattcg
    11341 cggggcgctg cagcagtcga tggacaacaa cgccgcggtg ttccgcaccg aggagaccct
    11401 gaagcaggcg ctcaccgaca tccacgcgct caaggagcgc tactcccgaa tcacggtgca
    11461 cgacaagggg aaacgcttca acaccgacct gctggaagcc atcgagctgg gatttttact
    11521 ggagctggcc gaggtcacgg tggtcggcgc tttgaatcgc aaggagtccc gcggcggtca
    11581 cgcccgcgag gactatccca accgcgacga cgtcaactac atgcgacaca ccatggccta
    11641 caaggaaatt ggggccgata aggagggccc cgagctgcgc agcgatgtcc gccttgattt
    11701 caaacccgtc gtgcagaccc gttacgaacc caaggaacgg aagtactaat gagcgtcgag
    11761 ccggacgtcg aaactttgga tccgccccta ccgccggtac cggacggcgc ggtgatggtg
    11821 accgtcaaga tcgcccggtt caaccccgac gaccccgacg cgttcgcggc caccggcggc
    11881 tggcagagct tccgggtgcc ctgtttgccc agcgatcggc tgctcaacct gctcatctac
    11941 atcaagggct acctcgacgg cacgctcacc ttccggcgat cctgcgccca tggggtgtgc
    12001 ggctctgatg ccatgcgcat caacggggtg aaccggctgg cctgcaaggt gctgatgcgt
    12061 gacctgctgc cgaagaagaa gggcaaatcg ttgaccgtca cggtcgagcc gatccgcggg
    12121 ctgccggtgg aaaaggacct ggtggtcgac atggagccgt tcttcgacgc ctaccgggcg
    12181 atcaaaccgt acctgatcac cagcggcaac ccgcccaccc gcgaacggat ccagagcccg
    12241 accgaccgcg cccgctacga cgacaccacc aagtgcatcc tgtgcgcgtg ctgcaccacc
    12301 agctgcccgg tgttctggca cgagggcagc tacttcggcc cggcggcgat cgtcaacgcg
    12361 caccgcttca tcttcgacag ccgcgacgag gccgccgccg agcgcctcga catcctcaac
    12421 gaggtcgacg gggtgtggcg ctgccgcacc acgttcaact gcaccgaatc ctgcccacgg
    12481 ggcattgagg tgaccaaggc gatccaggag gtcaagcgcg cgctgatgtt cacccgctga
    12541 gggcttgcgc gagcagacgc aaaatcgccc gaaaaccagt ggttttgggc gattttgcgt
    12601 ctgctcgcgc agccgggtct acagcgttgc caggtgctgt ttggttgcgc caggaaccgc
    12661 agtcaacgca atcgactgat cgaaggtgac aaatcggcca tcatgagcga ccgcgagggc
    12721 cagcaagtac gcgtcggtga cctgtttggg gctgtgcagg cgggaacgat cgatgacctt
    12781 tgagtcgaga atgctgacgg tgcaggacca gaactcgtga tagcgcgtgt gcgtcgcacg
    12841 agccaacaag tcgatggcat gggctaccga gattgggctg ggatagcgcg gttggctgat
    12901 gacgcggacg aacccgtttt gggtgatcgc acaggaagcc catccccgct cgatctgccc
    12961 ggtgatccac gctcgggcgc gctcgtggtc gacgtgatcg cggtccaaca gcgccagtag
    13021 cacgttgacg tccaacagcg ctcgcatcga tcacacggcc tcctcgtcac gaagccgatc
    13081 gatcagcgcg ttcgataccg ctccaccgcg atgaggcagg ggttcgaagc catgaaaggc
    13141 gtcctcctgg ctcgccgcag gctggggatt ctggttggtt aacgcttgcc gggccagatc
    13201 cgacaggatt tcacccgcgg tgcgcttctc cctgcgtgcc cgttccttca cggccagcaa
    13261 tacatcgtcg tcgatggaca acgtggtgcg catgcatcag atgctatcgc accaatctgg
    13321 gcgcaacgcg tctacaggat ggccagcgct cgcggcattg agaatctcct tcgtgggtgc
    13381 actcccacgc gaggtagggg ccgacgacca ccatctatgc ccctggcaac ggtgagcgcc
    13441 gcgcgatcat gatccgcgac ggcgccgaat cgcagttacc ctgcccctcg tgtacaacgg
    13501 tgaagtcggc aggaagcaga cacgctggct ctcccggctt gacacgtcgc ttcgcgctgg
    13561 ctgtgcccgc ctcggcgcca ctgagagcca gcgactccca tgccaatacg ccgcctggca
    13621 tcaccgcctc acaggcgcgg tgaaatatcg ccgcatccca aaagagcctg ctgagcacca
    13681 gcgcgaaacg cgtctcgccg ggttcccagc agcccaagtc ggcctgcacg aggttgagcc
    13741 gatcggccac gcctcgacgc acggcctcgc tgtccagctg cagcagcgcg acatcggaca
    13801 catcgattgc ggtgacctgg cggccgtggg cggccaacgc cagtgcggta cccgatcgac
    13861 cgctggctaa ctccagaacg ggaccgtccg gaacgcctgc tctgaggaca tcggcgagcc
    13921 aaggcaccgg ggcaaacggc gcgtgcgccg aacccgcgcg ttcgtatcgc gcgttccagt
    13981 cgacgcggtt ggggtgctcc cgcagcgccg gatccgtctg cacgctcatg gccgattggc
    14041 cacccactca acaccgtcga gtgcgaactc cttcttccat atcggcacat cctgtttgag
    14101 ccgctcgatg cacatgcgag cggcgtcgaa cgcggccgcg cggtgaggag ccgaagcacc
    14161 gatgacaacc gccgcatcac cgatgcgcaa ttcaccggtc cggtgtgcca cggcaactcg
    14221 cacaccgtcg gcctgtcgtt cacactcttc gatgatgtcc atcagcgtgc ggtgcaccat
    14281 ggccggatag gcctcgtagt acaacttggt cacttcgtgg ccgttgttgt tgttacgcac
    14341 ggtacccacg aagatgacgg cgccgccctg ggaaggtcca gatatcgcgt tgagcacttc
    14401 atcgacgctc agcggctcat cggtgagccg gcagtagaca tcggagcccc cggcaacctg
    14461 cggtatgaac gccaccgtgt cgccatcgtc gagaatcgtt gatgctggcg ctatggattc
    14521 gttaacggcc atccgcactc gcttgcgaaa atcagcaagt ggcggatagt cgatttgcaa
    14581 ttggtcgact aagccgtcga cggtggtgcc gctttcgagt gagatcttct cgtgagcgac
    14641 cttgcacgct tcgcgaaccg cgccaaagta gagcacattg acagtaatca ttcaacatcc
    14701 atcctcggtg gagccaccat cgctgggttt gacgtccgcg tcgtgccgcc ggtaatgacc
    14761 cgatcggcca ccgctttttt cgtccaatct gatatccgtg atcgtcatgg cacggtcgac
    14821 tgctttgcac atgtcgtaaa ccgtgagcgc tgtcaccgta acggcggtca acgcctccat
    14881 ctccacaccc gtacgtgcca ccgtggtcac cgtcgccgca atcgagagcc ggtccgcgcc
    14941 ctgcggctcg agcgtgacgg tgaccgcctc gatccccagc gggtgacaca gcgggataag
    15001 ctcaccggtc cgtttggccg ccataatgcc ggctatccgt gcggtcgcta tgacatcgcc
    15061 ctttgccgcg gtgccgtgac agatcatgtc cagggtcgac ggtttcatca ggacggcccc
    15121 ggatgcccgc gctcgccgca aggtcaccgc cttcgccgac acatcgacca ttcgggcggc
    15181 gccttgttca tcaaggtggg taagcacccc atcgtggtcg ttcaccgtgc cacctgctgg
    15241 ctgcattgct catcgtgcac tgcgctgaaa gcctcggcga ggtcgaagtc gacgcgagtc
    15301 aaacagtgca tctggcgcgt ccaacaagtc aaccgcaccg accgcttgtt atggacactg
    15361 aaccgccccg gcatgtccgg agactccagt tcttggaaag gatggggtca tgtcaggtgg
    15421 ttcatcgagg aggtacccgc cggagctgcg tgagcgggcg gtgcggatgg tcgcagagat
    15481 ccgcggtcag cacgattcgg agtgggcagc gatcagtgag gtcgcccgtc tacttggtgt
    15541 tggctgcgcg gagacggtgc gtaagtgggt gcgccaggcg caggtcgatg ccggcgcacg
    15601 gcccgggacc acgaccgaag aatccgctga gctgaagcgc ttgcggcggg acaacgccga
    15661 attgcgaagg gcgaacgcga ttttaaagac cgcgtcggct ttcttcgcgg ccgagctcga
    15721 ccggccagca cgctaattac ccggttcatc gccgatcatc agggccaccg cgagggcccc
    15781 gatggtttgc ggtggggtgt cgagtcgatc tgcacacagc tgaccgagct gggtgtgccg
    15841 atcgccccat cgacctacta cgaccacatc aaccgggagc ccagccgccg cgagctgcgc
    15901 gatggcgaac tcaaggagca catcagccgc gtccacgccg ccaactacgg tgtttacggt
    15961 gcccgcaaag tgtggctaac cctgaaccgt gagggcatcg aggtggccag atgcaccgtc
    16021 gaacggctga tgaccaaact cggcctgtcc gggaccaccc gcggcaaagc ccgcaggacc
    16081 acgatcgctg atccggccac agcccgtccc gccgatctcg tccagcgccg cttcggacca
    16141 ccagcaccta accggctgtg ggtagcagac ctcacctatg tgtcgacctg ggcagggttc
    16201 gcctacgtgg cctttgtcac cgacgcctac gctcgcagga tcctgggctg gcgggtcgct
    16261 tccacgatgg ccacctccat ggtcctcgac gcgatcgagc aagccatctg gacccgccaa
    16321 caagaaggcg tactcgacct gaaagacgtt atccaccata cggatagggg atctcagtac
    16381 acatcgatcc ggttcagcga gcggctcgcc gaggcaggca tccaaccgtc ggtcggagcg
    16441 gtcggaagct cctatgacaa tgcactagcc gagacgatca acggcctata caagaccgag
    16501 ctgatcaaac ccggcaagcc ctggcggtcc atcgaggatg tcgagttggc caccgcgcgc
    16561 tgggtcgact ggttcaacca tcgccgcctc taccagtact gcggcgacgt cccgccggtc
    16621 gaactcgagg ctgcctacta cgctcaacgc cagagaccag ccgccggctg aggtctcaga
    16681 tcagagagtc tccggactca ccggggcggt tcagaggcaa ccaccatggt tgttgttgga
    16741 accgatgcgc acaagtacag ccacaccttt gtggccaccg acgaagtggg tcgccaactc
    16801 ggtgagaaga ccgtcaaggc caccacggcc gggcacgcca cagccatcat gtgggcccgt
    16861 gaacagttcg gcctcgagct gatctggggc atcgaggact gccgcaacat gtcggcgcgt
    16921 ctggagcgtg acctactggc ggccggccag caggtggtgc gggtacccac caagctgatg
    16981 gcccagaccc gcaagtcggc gcgcagtcgg ggcaagtcgg atccgatcga tgcgctggcg
    17041 gtggcgcggg cggtgctgcg tgaaaccgac ctacccctgg ccacccacga cgagacgtcg
    17101 cgggagttga agttgttgac tgaccgtcga gatgtccttg tggcccaacg cacgtcggcg
    17161 atcaaccggt tgcgctggct cgtccatgaa ctcgatcccg agcgggcacc ggcagcacgc
    17221 tcgctcgatg ccgccaagca ccagcaggcc ctgcggacct ggctggacac ccagccagga
    17281 ttggtcgccg aactcgcgcg cgccgagctg accgacatca tccggctcac cggcgagatc
    17341 aacaccctag cccagcgcat cagcgcccga gtccaccagg tcgcccccgc actgctggaa
    17401 atccctggct gcgcggagct gactgcagcc aaaatcgtcg gcgaagccgc cggagtgacc
    17461 cggttcaaaa gcgaagccgc cttcgcctgc catgccgcag tggctcccat cccggtgtgg
    17521 tcgggcaaca ccgccggcca gatgcggctc agccgctcgg gcaaccgcca gctcaacgcc
    17581 gccctacacc gcatcgcact gacccaaatc cggatgaccg acagccgggg ccaggcctac
    17641 taccaaaggc tgcaagacgc cgggaaaacc aaacgcgcag cactacgctg cctcaaacgc
    17701 cgcctagccc gcaccgtctt ccaggccctg cgcaccgtcc accagcccag ctccgaacac
    17761 acccaacccg cggccgcttg ccataggagc tattgctcgt cacacctcgg cgagccacct
    17821 cgtctaacgg atatgacaca gaaaacccgc atccagcccc tacctcccaa gcgagccggc
    17881 ctgttgatcc gcgcactgta tcggatcgcc aagcggcgct tcggcgaagt tcccgagccg
    17941 ttcacggtca ccgcacatca tcggcggctg ctgatcgcca atgtggtgca cgaagccctg
    18001 ctgcagcgag cgtcgcggaa gctaccgccc agcgtccgtg agctggcggt gttttggacc
    18061 gcccgcagca tcggctgctc gtggtgcgtg gacttcggag ccatgctgca gcgcctggac
    18121 gggctggacg tggacaggct cacggacatc gacaattacg ccacctcatc gaaattcagc
    18181 gacgacgaac gcgccgccat cgcctacgcc gaggcgatga ccgcagaccc gcattcggtg
    18241 accgacgagc aggtggccga cctgcgggcc cgcttcggcg aggccggcgt gatcgagctg
    18301 acttaccaga tcggcgtgga gaacatgcga gcccggatga attcggcgct gggcatcacc
    18361 gagcaaggct tcaattccgg tgatgcctgc cgcgtcccgt gggctgcgcc cgacgttcct
    18421 tcagcggaga gccggtgaac ttgtcgggat tggcgatatc ccacagcgcg cacacctttc
    18481 cgtcgcgcac ggttatcgcg gtgatccgcg gcgccatcgc ccgatacccg tcgaccccgg
    18541 gtaagcccgc cgtgtaggcg ccgagctctc cgttgaccag cgccagctga ttcgcgccga
    18601 agagccccgg gccgtaacgc tggaccagcc cgagtatgaa ccggaccacc ttgtcggatc
    18661 cgcggacggc ccgtaccgct gtgggcgcct tgccattcga atcgccggta aacgtcacgt
    18721 cgggatgcag cagcgacacc accgtgtcca ggtcaccagc ggccatggcg gccatcagcc
    18781 ggccgaccac ctcgttgtgg gccggatccg gatcccccga tatcagggcg ggctgcgccg
    18841 tgacggcctt gcgggcccgc gacgccagct ggcgcgcggc ggcctcgctg gttcccagca
    18901 cctcggccac ttcggcaaac ggcacggcga acccgtcgtg cagcacgaac gcgacccgct
    18961 gatcggggcg cagccgctcc agcaccacca tggccgcgaa cctggcgtcc tcggcggcca
    19021 ccacggcggc caacggatcg gtcgcgtcca agccggtgac caccggttcg ggcagccagg
    19081 tgccggtgta ggtctcccgc cggtgcgccg ccgacctcaa cttgtccaga cccagccggc
    19141 tcaccacggt ggtcagccag gcccgcgggt cggcgatcac ggtgtccggt gagtcccagc
    19201 gcagccaggc ctcctgcacg atgtcctcag catcggcgac cgtgccggtc agcctgtagg
    19261 cgaccgacat gagatgctgt cgcagtgcct cgaattcgga aacctccatc gaggtcattg
    19321 cccgagccta gcgctgcgct cgccaacacg acgacacgaa acctttggtt gcacttcgcc
    19381 cggcacggtg ccggcatcca acacccggtc atcgtccgcg gcgacggcgt caccatcttc
    19441 gacgaccgcg gcaagagcta tctggacgcc ttgtccgggc tgttcgtggt gcaggtcggt
    19501 tacggccggg ccgaactcgc cgaggcggcc gcgcggcaag ccggcacgct ggggtatttc
    19561 ccgctctggg ggtatgccac cccgccggcg atcgagctcg ccgagcgcct ggcccgctac
    19621 gcgcccgggg acctaaaccg ggtgtttttc accagcggcg gcaccgaggc cgtcgaaacc
    19681 gcctggaagg tggccaagca gtacttcaag ctcaccggca aaccgggcaa acaaaaggtc
    19741 atttcacgct cgatcgccta ccacggcacc acccagggcg cgctggcgat caccggcctg
    19801 ccattgttca aggcgccatt cgaaccgctg acgccgggcg gcttccgggt gcccaacacc
    19861 aatttctacc gagcaccgtt gcacaccgac ctcaaagagt tcgggcgatg ggctgctgac
    19921 cggatcgccg aggccatcga gttcgaaggc cccgacaccg tggccgcggt gtttttggag
    19981 ccggtgcaga acgcgggcgg ctgcatcccg gcgccgccgg gttatttcga acgggtccgc
    20041 gagatctgtg accgctacga cgtgctgctg gtctccgacg aggtgatctg tgcgttcggc
    20101 cggatcgggt cgatgttcgc ctgtgaagac ctcggctacg tgcccgacat gatcacctgc
    20161 gccaagggcc tgacgtcggg ctactcgccg ctgggcgcga tgatcgccag cgaccggttg
    20221 ttcgaaccgt tcaacgacgg cgagacgatg ttcgcacacg gctacacgtt tggcggtcat
    20281 ccggtgtcgg cggccgtcgg cctggccaac ctcgacatct tcgagcgcga gggtctcagc
    20341 gatcacgtca agcggaattc ccccgcgctg cgggccaccc tggagaaact gtacgacctg
    20401 cccatcgtcg gcgacatccg cggcgagggg tatttcttcg gcatcgaact ggtcaaagac
    20461 caggcgacca agcaaacctt caccgatgac gaacgcgcac gactgctagg ccaggtatcc
    20521 gcggcgctct ttgaggccgg gctgtactgc cgcaccgacg accgcgggga ccccgtcgtc
    20581 caggtggctc ccccgctgat tagcggacag cccgagttcg acaccatcga aaccatcctg
    20641 cgcagcgtgc tcaccgacac cggacgcaaa tatcttcatc tgtaactttc gtcccgccag
    20701 tcacagcgcg gctcctcgcg gtcgggccgc cgatcaccta ctctgcacag acgatggcct
    20761 tcttacgttc ggtatcgtgc ctggcagcag ccgtgtttgc ggtaggcacc ggaattggtc
    20821 tacctaccgc ggccggcgaa cccaatgccg caccggcggc gtgcccgtac aaggtgtcca
    20881 ccccacccgc cgtggactcg tcggaggttc ccgcggccgg tgaaccccca ctgccgctgg
    20941 tggtaccccc caccccggtc ggcggcaacg cgctgggcgg ctgcggcatc atcaccgccc
    21001 ctggcagcgc gccagcgccc ggcgacgtct cagccgaggc ctggctggtg gcggacctgg
    21061 acagcggcgc ggtgatcgcc gcccgggatc cgcacggccg gcaccgcccg gccagcgtca
    21121 tcaaggtgct ggtggcgatg gcgtccatca acacgctcac cctcaacaag tcggtcgccg
    21181 gaaccgccga cgacgcggcg gtcgagggca ccaaagtcgg ggtgaacacc ggtggcacct
    21241 acaccgtcaa ccagctgctg cacgggctgc tgatgcactc cggcaacgac gctgcgtacg
    21301 cgctggccag gcagctcggc ggcatgccgg ccgcgctgga gaaaatcaat ctgctggccg
    21361 ccaagctggg cggccgggac acccgagtgg ccacgccgtc cggactggac gggcccggca
    21421 tgagcacgtc ggcctatgac atcggcctgt tctaccggta cgcgtggcag aacccggtct
    21481 tcgccgacat cgtcgcgacc cgcaccttcg acttcccggg gcacggcgac catccaggct
    21541 acgagttgga gaacgacaac cagctgctct acaactatcc gggcgcgctc ggcggcaaga
    21601 ccggctatac cgacgacgcg gggcagacct tcgtgggcgc ggccaaccgc gacggccggc
    21661 ggctgatgac ggtgctgctg cacgggaccc ggcagccgat cccgccgtgg gagcaggcgg
    21721 cgcacctgct cgactacggg ttcaacaccc cggcaggcac ccagatcggg acactgatcg
    21781 aacccgaccc gtcgctgatg tccaccgacc gcaatcccgc cgaccggcaa cgagtcgacc
    21841 cccaggccgc ggcgcggata tcggccgccg acgcccttcc ggtgcgggtt ggcgtggccg
    21901 tcatcggcgc cctgatcgtg ttcgggttga tcatggtcgc gcgggcgatg aaccgccggc
    21961 cgcagcacta gctgcttacc ccgatacctt cggcgtcgtt tgcgggcggg catcctagcc
    22021 ggccttggtc ggcaccgaaa tcggggcttg accagcggtt gaccgcgtga cgacgctgtg
    22081 gcagcctcat cgaaatgact acagccctat accaggacgc ggggttcacg cccgccgggg
    22141 cgcccgacga ccccgaccgc gtggtggacg tgctgagcgc cccggtaccg gtcaactgac
    22201 cagatcgggg cgccgggcgc tcctcgtcgg gctcaccgcc gccagcgtcg gcgtcctcta
    22261 cgggtacgac ctttccgcca tcgcgggtgc gttgctgtct ctcagcgagg aattcgaact
    22321 caccactcga gaacaggagt tgctgaccac cacggcggtg ctcggccaga tcgccggggc
    22381 gcttggcggc ggcatcctcg ccaacgcgat cggacgcaag aaatcggtgg tgctcatcgt
    22441 cgccggctac gcagtgttcg ccctgctcgg cgcgacctcg gtgtccgtac cgatgctggt
    22501 ggtggcgcgt ctgctgctgg gtgtgacaat cggcctgtcg
//
