LOCUS       NC_022571.1            26212 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_022571.1 Clostridium saccharobutylicum DSM 13864, complete
            sequence.
ACCESSION   NC_022571
VERSION     NC_022571.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-13 23:58:13
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 828096
            Orig. end    :: 854308
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..26212
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[838096:844308]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..16212
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..26212
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..26212
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="Putrescine2spermidine"
                     /region_number="4"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             316..1734
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_688"
                     /sec_met_domain="Radical_SAM (E-value: 9.4e-12, bitscore:
                     43.6, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYNVKSNVATEFISDEEILSTLEFAQKNKNNKKLINEILEKAKDC
                     KGLSHKEAAVLLECDLEDETQKMYKLAKEIKQRFYGNRIVMFAPLYLSNYCVNGCTYCP
                     YHHKNKHIRRKKLTQEEIKNEVIALQDLGHKRLALETGEDPVNNPIEYVLESIKTIYSI
                     KHKNGAIRRVNVNIAATTVENYAKLKEAGIGTYILFQETYNKKAYEELHPTGPKHDYAY
                     HTEAMDRAMDGGIDDVGMGVLFGLNLYKYDFVGLLMHAEHLEAAKGVGPHTISVPRIRP
                     ADDINPDEFTNAISDEIFQKIVAILRITVPYTGLIISTRESQKTREKVLELGVSQISGA
                     SCTSVGGYSEKEKEEDNSAQFDVNDDRTLDEIVNWLLEMGHIPSFCTACYREGRTGDRF
                     MTLVKAGQIANCCQPNALMTLKEYLEDYASEDTKKKGEEVIRNEIPNIPNEKVRKVVLE
                     HLEDLNEGKRDFRF"
     CDS             1981..3042
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_689"
                     /sec_met_domain="Peripla_BP_1 (E-value: 2.9e-07, bitscore:
                     28.2, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIFNKMLTIIIASIVMTTMFSIYSSNLTNANSQVVEGKPVSVAV
                     LFYRFNNEPYVSLLRQNFEEIQIENKDKVKFTFYDGEDNQAIQNRSIDKLLESRDADII
                     FLDLVDTKNVQEIINKIKENNIPVVIFHREPLNIESVKSYNKAFYVGGNPEEAGRLEGK
                     IIIDAWNKEKEIIDRNGDNIMQYVMLFGERDNLDAIGRTRYSLSAIHDAGINTEEIALK
                     VCNWDENLAENTIKTIFLQQGNKIETIISNNDSMAIGAIKALQKYGYNEGDKVKTIPVV
                     GVDAIPQAQEFIKKGYMAGSVLQDATAMVKAVYTIGMNLVHDRLPLDGTVYKVDDTGVA
                     IRIPYKEYTDNLL"
     CDS             3159..3725
                     /locus_tag="ctg1_690"
                     /transl_table=11
                     /translation="MSRLEEILEYNEKFVSENEYEQYVTSKNPKKKMAILSCMDARLTE
                     LLPKAMNIKNGDAKIIKDAGATVMHPFGGVTRSIIVAIYEFGAEDVFVVGHHGCGMSNL
                     DTKSIVNKMIERGIDKETISMLNNAGIDVEGWLHGFESVEDSIRESVRAIKNHPLIPKD
                     IRVHGLIMDSETGKIDIVINGDEVH"
     CDS             complement(3906..4319)
                     /locus_tag="ctg1_691"
                     /transl_table=11
                     /translation="MNPLLNMLLGSLFPGMGGMNGNTMPNGNGMNPLLNMLMGSLGGGM
                     NANMMNNPLFSMLMGNQNNMGNMNMSNTPNMNNSNTNSSNMNNMNMNPNMNMGNINPIL
                     SMLMNNQNNMGNMNMTNRPNMNMNSNRSSNSKR"
     CDS             4653..5741
                     /locus_tag="ctg1_692"
                     /transl_table=11
                     /translation="VRDYIGIGLSDDIKESVEQATDGLMHPKVIFVFAEYSKFEEAICL
                     MQEKYPNTPIVGTTGYCFANKNIIRNNIVIWAINEGIDVEVGVLENISKFPIKDIKSLE
                     ENIGKINAGNDNTVCIEFCTGAEEKIVSTINSAISKKNIPLIGGTSQGANDKGIKCVSL
                     NGKVYLDTCVYALIKNLNGKIKTYSENIYKEKSGNFIATKVDVQNRRILELNGKKAGQV
                     YCETLGITKNQINDCVLTNPLARVIGKEDFVIAIKLVDDEDSLNCYKRVNQNDVLNILE
                     LQNYKKAIQNTLDRIKADFANISFIFSIDCIYRFLLFESMNFTKEYCNIMGSIGQHIGI
                     VGEGEQYINQHVNQTMICVVFE"
     CDS             5752..6753
                     /locus_tag="ctg1_693"
                     /transl_table=11
                     /translation="VNIMRFLFSSKNEDESNKNIKLEDKFKVKEETNLSEEIYPITYSI
                     NYLKNRTYDLIKEESSTTNEIKKIEESFIGVKNKAKEINISVSSFNEHFNDIKVVSDEF
                     SNRMNNILKCVEESQKKVMNLKDSSKSVEESFKIIENTFEQFKKSYVTIKEYTTSIIDI
                     ADQTNLLALNASIEAARAGEQGKGFAVVAEEVKDLSGEIKELVNGVNTSMDNVENDTKQ
                     LNISLQNSQSALNESYENVNDTEEIFDEIKVNVNGVSDINEKISNAINNSNLEIKNISN
                     NIEHSTKYYDRVTSDINNLNTQLTHKGIIFEDINNFLEQMNPLINSIVEKHE"
     CDS             7119..7931
                     /locus_tag="ctg1_694"
                     /transl_table=11
                     /translation="MTIGKIQVNTFDVITFVGMAITLFTSILNLIQNKKGLYINNITRY
                     RVTWINTLRVQISTLKELSNITNLYVITREGVDKVAYRRELEKVVSLIKMHLNFCGQLD
                     NKLILKVEELKCIINSYLLMHYFRNIIKSINSDDEIENKFNEAIDVISEKKVLDELLNI
                     ARNTKNIKNTISIKNLSLLDLRYKIKAEYNNNTELIICAVKESEYVIQRWEYKIEKINK
                     EIDEIVQIYLKSEWSRCKKETRLWPFSRYNEEKAIKRLEKEYKAQAKK"
     CDS             8091..8429
                     /locus_tag="ctg1_695"
                     /transl_table=11
                     /translation="MEGQTLNNSNISSGDLKSNITTLPNNINIENATNNNNTKESITAL
                     VKHGGEVVGYELSNGQKISKEQGVQLARNDGINGVTVAISRKGEEYLRSLPDQDENNNL
                     KSLPIINE"
     CDS             8701..9396
                     /locus_tag="ctg1_696"
                     /transl_table=11
                     /translation="MSDLSDLKELTKAKAAREMQELQDKIITRLSSIKRDGIDELIKYL
                     LERTDYFTAPASTKFHSNFDGGLALHSDNVVELLMQKNQQYKLGLNNDTIYLTGYLHDL
                     CKCNLYEKTMRLKKDEMTGKWIGYASYEFDEKIPLGHGEKSVILLQQFVKLTLEECLMI
                     RWHMGAYVPKDEYRDYNKAIEMYKSVLAFSNSDAEASHFLEEVREPELYAIEEYNRYVK
                     EKAMKKLNN"
     CDS             10001..10816
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: AdoMet_dc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_697"
                     /sec_met_domain="AdoMet_dc (E-value: 3.5e-30, bitscore:
                     102.4, seeds: 266, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGLENKLKLYGFNNLTKTLSFNIYDVCYAKSEREQKDYIAYIDE
                     QYNSERLTNILCDVTDIIGAHVLNISKQDYDPQGASVTILISEETLAVKEIDPSCNKGQ
                     IDILKTRDTVVAHLDKSHVTVHTYPEYHPDNSIATFRVDIDVSTCGEISPLNALNYLIG
                     SFDSDIITIDYRVRGFTRDVDGKKLFIDHKITSIQDYIDEGTLKKYDAMDINVYQSNIF
                     HTKMLIKEIELQNYLFNRDVYEIKPKQRLEIENNLRKEMIEIFSGTNIY"
     CDS             10835..12298
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_698"
                     /sec_met_domain="OKR_DC_1_C (E-value: 6.7e-11, bitscore:
                     40.6, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 1.7e-131,
                     bitscore: 436.6, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDRESQSKAPIYEALMEYKKARVVPFDVPGHKQGRGNAMLREFL
                     GEQCLSVDVNSMKPLDNLCHPVSVIKEAEELAAEAFGSKHAFLMVNGTSSAVQAMVMSV
                     CKKGEKIIMPRNVHRSAINALVISGAIPVYINPGINKKLGIPLGMSVDDVKKAIKENPD
                     AKAVLVNNPTYYGICSNLKEITKLAHENGMYVLVDEAHGTHFYFGENMPMSAVEAGADM
                     AAISMHKTGGSLTQSSFLLLNCDLNEGYVRQIINLTQTTSGSYLLMSSLDLARRDLVLN
                     GDKIFKKVIELAEYARGEINKIGGYYAFSKELIDGDAIYDFDVTKLSIFTRDIGLAGIE
                     VYDLLRDEYGIQIEFGDIGNILAIISVGDRNLAIERLISSLSEIKRLHSKDKAGMFDHE
                     YINPEVVLTPQEAFYSPKKSVPMNESDKEICAEFVMCYPPGIPILAPGERITKEILDYI
                     DYAKEKGCFLTGTEDIKIENINIVDSVNS"
     CDS             12409..13254
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_699"
                     /sec_met_domain="Spermine_synth (E-value: 2.8e-59,
                     bitscore: 197.7, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 3.6e-15,
                     bitscore: 53.6, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELWYTEQHTENVRFSIKVEKEIHTEQTEFQRIDVLEAKEFGKFF
                     TLDGLMMVTEKDEFIYHDMIVHVPMATNPNIKKVLVIGAGDGGTIRELTRYKTIEKIDM
                     VEIDERVVEVCKEYFPQTACKLDDPRVNIFFEDGLRFVRNKENEYDLIIVDSTDPFGPG
                     EGLFTKEFYGNCYKALKEDGILVNQHESPYYDFHARAMKDAHKKIVGFFPVIRVYQAHI
                     PTYPSGHWLFGFASKKYDPIKDLDADAWNKLGIKTKYYNTDLHVGCFALPNYVLEMLEN
                     "
     CDS             13417..14619
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_700"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 2.3e-42, bitscore:
                     144.0, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 2.6e-38,
                     bitscore: 129.3, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKALIIGAGGVASVAIHKCCQNSEVFEEICIASRTLSKCDAIKS
                     SLEGKTKTKIQTAQVDADNVPELVALINKFKPEVVINLALPYQDLTIMDACLETKVHYI
                     DTANYEPLDTAKFEYKWQWAYREKFEKAGITALLGTGFDPGVTGVFSAYAQKHYFDEIN
                     YIDILDANAGDHGYPFATNFNPEINIREITANGSYWENGKWIETEPLEIKRVYDFPEIG
                     PKDMYLLHHEELESLGLNIKGIKRIRFWMTFSQKYITHLNVLENVGMTSIEPIEFEGKQ
                     IVPLQFLKAVLPDPASLGPRTKGKTNIGCIFQGKKDGKDKTYYVYNVCDHEECYKEVGS
                     QAISYTTGVPAMIGASLVMKGLWKKPGVYNVEEFDPDPFMEELNKWGLPWKESFDPTLV
                     E"
     CDS             15073..16212
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_701"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 1e-12, bitscore:
                     46.2, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDIDISKLPSPCYLVDERLLKKNLEVLDYVQKETGANIILATKS
                     FSMYSTFPLIGKYLKGVTSSSLHEARLGYEEMGKEVHIFSPAYRDDEFDDIMKYSDHIV
                     FNSFSQFKKYRDKIKNFTGKKIECGIRINPEYSEIETDIYNPCFKNSRMGVTLDNFEED
                     ELEGIDGLHFHTMCEQNSDTLARTIKVVDEKFGKYIKKMKWINFGGGHHITREDYDIET
                     LIKSINFIKDKYGVKVYLEPGEAIALNAGFLVSTVLDTMKNGMDIAILDTSAECHMPDV
                     LAMPYRPNIIGAGKPNEFEFTYRFGGPTCLAGDIIGDYSFKEPLKPGDKLVFCDMAIYS
                     MVKNNTFNGVNLPAIVKYSEEKGIEIIKQFGYEDFKSRL"
     CDS             16909..18351
                     /locus_tag="ctg1_702"
                     /transl_table=11
                     /translation="MKDDFISYENLRISTYEVKFVKEMHIENCLNNHATLNLICILDDE
                     MKDNCVQDTDQETPIEVFYEKEEAHFSLFNGVVTKVKVKVINYVYTLFIEAKSFDYKMD
                     IEKKKRDFQNINMSTHELIDEVMKSYPNANYNINIPNEPIGEFILQYNETDYEFLKRIV
                     SRYNQTLISEMELKNIYLYFGTPEKHVELKTQIVNYTISKTVHEYNDVKNNDVFDVLET
                     DFITYKIRTQEILNLGENFDFKGRQFYIYKAVYTMEEGNLENIYELRAKGGLRSKRLFN
                     MNVIGISINGSILEVKRDRVKVQLEINSDTDASIAYWFPYSTVAASKDGGGWYCMPEVG
                     ERIRLYCPTKDESKAFVINAIDTHEAKSGGGANEDRMSNPDNKSLKTDAGQEVKFTPNG
                     VSIECSGGQAAVNLNKDGTIEITGQKNINIACAQNLSLKAGNEMTISAQKSVDILCESG
                     SNVILSEADEILVNGTRVQNNG"
     CDS             18371..18985
                     /locus_tag="ctg1_703"
                     /transl_table=11
                     /translation="MNIDEKIAKLKMQQRLEKENELKKESQKEEISSIEEEITLKEVIE
                     QISEGALRINNTNFKFVKKVFLNGKLEIPMPLAYFEERVNTEKNTTLVNDNNGVSFTLA
                     YVDKGVQKQSFAKFKKGMEKNFKDIDLYLEWMEEGEVGEGASKVSYGTYKTPTGKGQIY
                     NLIFYREYKGTLIIGNYNCFEKDIKTWGLLIKASIMLMKVR"
     CDS             19124..20566
                     /locus_tag="ctg1_704"
                     /transl_table=11
                     /translation="VEGNQIGEAINYEKVRVNGYNLESIKSLKLETNINEHTVLNLTGI
                     LKNEVKDSDIASTTNNKTIEVYYVENESTTLFYGIVTNIEINVKFDVYMLNIEAKSMSY
                     LMDIQLKSKSFQNISMTTHTLIKSIMQNYSDSNYIINIPDEEVEELLVQYEETDWEFLK
                     RIASKYNQGLFPVMEGKKIQFVVAVPEQSKELKSENVNYKIRKDLEHYEYMHQNYLPDA
                     SEVDYITYEMESYVVLKLGDNIQFQGQNFYVYHGSYEIKDGTLINNYKLRIKNGLRQKR
                     IFNTKVIGSSIDGKIIQVQSDLVRIHLEIDEVQDQGTAYWFKFSTMSASSDGSGWYCMP
                     EMGDSVKVYFPTKDEDEAFAVSAVSGYEQGVGESEDRMGNPDNKYLRTTHDKQVKLTPD
                     GIFISCDSGQADMSLTSDGTLSITSQNNIDINAEQNIKIEAQKSFLVSAKQGINFACDK
                     GGGLEFDNSGNIKEKGTKVNNN"
     CDS             20632..21735
                     /locus_tag="ctg1_705"
                     /transl_table=11
                     /translation="MNREESLKEFKEKIVKALGEESIETFEKNFKDNEEKVKGMLINGM
                     RTLINRAKNIKENNSENKIAVFQFELLRINILNESYKILIHGYNSSWYLDPKPIYEEID
                     LSFLFEPFIKVKEKLIKEKRIYMGKVNNYDIQKMIFELVVKCYKNMSKTIRNWFWNLDE
                     EEWINERVIEDFYIVKWSEYQGRSETLFAMDNREKNIKELLELKEQPEEKLPFVYTVWK
                     NSILEDGVLAKQNMLFINFKGSNLKDIDFSECNIVRGQFKDTEVKRCTLVKCNLIGSSF
                     QNSKIEDSDFSNGNCTGVDFRQAELRYVNFSNSNLKKSNFINAKFKNVSFEGADLEDAV
                     FSAKDIPFINLTSEQLQTIYIDGGEER"
     CDS             21732..22253
                     /locus_tag="ctg1_706"
                     /transl_table=11
                     /translation="MKYFVLKQDRNLENAIEIEGFNNSQKMTLLKADEDKYKDSTNVLV
                     HGNENSIYPDLIQAPVLIISDELHKLFKLYENTVVYKIAVFSDLKRKKQKVYRLVLPEL
                     LDALSDKSVFFKNGWIDKIVLDDEKIGDYNIFQIKAGVDYYFIVSLDVVESMLKRGLFV
                     GIKFEEVEVI"
     CDS             22255..23028
                     /locus_tag="ctg1_707"
                     /transl_table=11
                     /translation="MASENEEKYGVIAGTAINEVEKGVKGTVNSVKQIGTMAQRAGGFA
                     LRDATNEWKWLNLSPEEKAAEKEKEKQAAEEAKAEADKADADKAKAEDDEKERIKNLEK
                     SYIVHTAAITCSCALHESYVVVPEGHGEFIHGIPQLNIGDSKPEINIRSFGICKSPQNP
                     SVQENAKKIADEVKNRPKGFTEKVMDFFSKPPAEDVGKDLLEQCVGECTPIIATEWIDG
                     KEDVLVDGKPALLGKCKLTCLYGGEIKLYTSGQRE"
ORIGIN
        1 gcactgattg gaattatagt tgaagatatg aactcaacag ataaaattaa tggtatttta
       61 catgaatatt ccgagtatat ggttggaaga atgggtatac cttataggga gaaaagtgta
      121 gcaataatta gtattgttat agatgctact aatgatgtaa taagctcatt atctggaaag
      181 ttaggcatga taaaaggtat aaatgttaaa acagtatatt ctaaaacagg aaagtaacta
      241 atctaggaat tttaattatt ttagataaat agctttaaaa ttaattaaaa ttttaaaaga
      301 aagaagtgtg taaaaatgta taacgtaaaa tcaaatgtag caacagaatt cattagcgat
      361 gaggaaatac tatcaactct tgaatttgcc caaaagaaca aaaataataa aaaattaata
      421 aatgaaattt tggaaaaagc taaagattgc aagggtttat ctcataagga agcggcagta
      481 ttactagaat gtgatttaga agatgaaact caaaagatgt ataagcttgc aaaggaaatt
      541 aagcaaagat tttatggtaa cagaatagta atgtttgctc cattatacct ttcaaattat
      601 tgtgtaaatg gatgcacata ttgtccatat catcacaaaa ataagcatat aagaagaaaa
      661 aaacttacac aagaagaaat taagaatgaa gtaattgcgc ttcaagattt aggacataag
      721 agattagcat tagaaacagg tgaagatcct gtaaataatc caattgagta tgtacttgaa
      781 agtataaaaa caatttatag cataaaacat aaaaatggtg caataagaag agttaatgtt
      841 aatattgcag caactactgt agaaaattac gcaaagctta aagaagcagg aataggaaca
      901 tatatattat tccaagaaac ttataataag aaagcatacg aagaacttca cccaacagga
      961 ccaaagcatg attatgctta tcatactgaa gctatggata gagctatgga tggaggaatt
     1021 gatgatgttg gaatgggagt attatttgga ttaaatttat ataaatatga ttttgttgga
     1081 ttacttatgc atgcagaaca tttagaagca gctaagggag ttggaccaca tacaataagt
     1141 gttccaagaa taagaccagc agatgatatc aatccagatg agtttactaa tgcaatttct
     1201 gatgagattt tccaaaaaat tgttgccata cttagaatta cagtaccata cacaggattg
     1261 ataatttcta caagagaatc acaaaagact agagaaaaag tattagaact tggtgtttct
     1321 caaattagtg gagcatcttg tacaagtgtt ggtggatatt cagaaaaaga aaaggaagaa
     1381 gacaattcag ctcaatttga tgttaatgat gatagaacat tagatgaaat tgtgaactgg
     1441 ttacttgaaa tggggcatat tccaagtttc tgtactgcat gttatagaga aggaagaaca
     1501 ggggatagat ttatgactct tgttaaagca ggacaaatag ctaattgttg tcaaccaaat
     1561 gcacttatga cgttgaaaga atatttagaa gattatgctt cagaagacac aaagaaaaaa
     1621 ggtgaagaag ttataagaaa tgaaattcca aatattccga atgaaaaagt cagaaaagtt
     1681 gttttagagc accttgaaga tttaaatgaa ggaaaacgtg attttagatt ctaacaaaaa
     1741 aattatatat ttaatggata gagagtatga gcttttagtt ttatgctctc tttttttgtg
     1801 tttaaattta agaatacatt gcaaaaatag tataaaatta ttattcaaac aaataataat
     1861 tttagaaatt atcataagac taataaaaaa ataatttata taatcatttt taaatttata
     1921 taacaataag taaattagat ttttgtatta gcattcagaa aattagatgg aggattaata
     1981 atgagaatat ttaataaaat gctaacaatt attatagctt caattgtaat gactacaatg
     2041 ttttcaattt acagctcaaa tttgactaat gctaattcac aagtcgttga aggaaaacct
     2101 gtaagtgtag ccgttttgtt ttatagattt aataatgaac cgtatgtttc cttattaaga
     2161 caaaattttg aagaaattca aatagaaaat aaagataaag tgaaatttac tttttatgat
     2221 ggcgaagata atcaagctat acaaaataga agtatcgata aattacttga aagcagagat
     2281 gcggacatta tcttcttaga tttagttgat acaaaaaatg ttcaagaaat tattaataaa
     2341 attaaagaaa acaatattcc agtagttatt tttcataggg aaccattaaa tattgaatct
     2401 gttaaatcct ataataaggc tttttatgta ggtggaaatc cagaggaagc tggcagattg
     2461 gaagggaaaa ttattataga tgcatggaat aaggaaaaag aaattataga tagaaatggt
     2521 gataatataa tgcaatatgt tatgttattt ggagaacgtg ataatttaga tgcaattgga
     2581 agaactagat attcattatc agcaattcat gatgcaggaa taaacacaga ggaaattgcg
     2641 ttgaaagttt gcaattggga tgaaaattta gctgaaaata ctattaagac aatatttttg
     2701 caacaaggaa ataaaataga aacaataatt tcgaataatg attcaatggc aataggagca
     2761 attaaagcat tgcaaaagta tggatataat gaaggagata aagtgaaaac tataccagtt
     2821 gttggagttg atgcaatacc acaagcacaa gaatttataa aaaaaggata tatggcaggt
     2881 tcagttcttc aggatgctac ggctatggtt aaagcagttt atacaattgg tatgaactta
     2941 gttcatgata gacttccact tgatgggact gtatataaag ttgatgatac aggagttgca
     3001 attagaattc cttacaaaga atatacagat aatttattat aatcaaaagt attgattata
     3061 ataaatatat atttaataaa aataatttta gtagtataat ctatttaata taagctatat
     3121 taaatagatt atactactat tggctagggg ggcgtaaaat gagtaggtta gaagaaatac
     3181 tagaatataa tgaaaagttt gtaagtgaaa atgaatatga gcaatatgtt acaagcaaaa
     3241 atcctaagaa aaaaatggct atattatctt gcatggatgc aagattaaca gaattattac
     3301 caaaggctat gaatataaaa aatggtgatg ctaagataat aaaagatgct ggtgcaactg
     3361 ttatgcatcc ttttggagga gttacaagaa gtataatagt agcaatatac gaatttggag
     3421 cagaagatgt atttgtagta ggacatcatg gttgcggaat gagtaattta gatacaaaaa
     3481 gcatagtgaa caaaatgata gagagaggta tagataaaga aactatatca atgttaaata
     3541 atgcaggtat tgatgttgaa ggatggcttc atggatttga atcagttgaa gattcaataa
     3601 gagaaagtgt gagagcaata aagaatcatc cgctaattcc taaagatata agagtacatg
     3661 gattaataat ggattcagaa acaggaaaaa tagatatagt aataaatgga gatgaggtac
     3721 attaaatttc tgccataaaa atttctccat tcatcaaatt agaataattt taatatgtac
     3781 aattatttca gtaatataca taaattcaag aaatataaaa gtagaataca cattacataa
     3841 tttaaaataa aaattaatgc attttaatag gcggcttaaa tttaagtcgc ctattggaat
     3901 tccaattatc tttttgaatt agaagatcta ttagaattca tattcatatt gggtctattt
     3961 gtcatattca tattgcccat attattttga ttgttcatta acatgcttag aataggattt
     4021 atattaccca tgttcatatt agggttcata ttcatgttat tcatatttga gctattagta
     4081 tttgaattgt tcatattggg tgtgtttgac atattcatat tgcccatatt attttgattg
     4141 cccattaaca tactgaataa aggattattc atcatatttg cattcattcc accaccaagg
     4201 cttcccataa gcatatttaa taaagggttc attccgttac cattaggcat tgtattaccg
     4261 ttcattccac ccataccagg gaaaagagat ccaagtagca tatttaataa aggattcatt
     4321 ttaacacctc attgttattt gtacttaata taatctatta tactttaggc taaaacgata
     4381 cataaaatta aaagtaatta taattttaag agaattataa tgtctgttca taattcgaat
     4441 taataaattt aaaagtcaag ttatactttt tagtaacata ttcttaaaat taataataaa
     4501 tttaggacat tgttaaatta taaagtaatg ggaataattc gatagattgt aactatatgt
     4561 gaaagtgtag tattatatag aatggatgtt aaaagtataa aatcaaattt tacacaaaaa
     4621 tgcaatattt ggtttatagg aggggattta tagtgagaga ttatattgga ataggactta
     4681 gtgatgatat aaaagaatca gtagaacaag ctacagatgg acttatgcat cctaaagtaa
     4741 tttttgtttt tgcagagtat agtaaatttg aagaagctat atgtttaatg caagaaaagt
     4801 atcctaacac tcccattgta gggacaacag gttattgttt tgcgaataaa aatataataa
     4861 gaaacaatat tgttatatgg gcaataaatg agggaataga tgttgaagtg ggtgttctgg
     4921 aaaatatttc aaagtttcca ataaaggata ttaaatcttt ggaagaaaat ataggaaaaa
     4981 tcaatgcggg aaatgataat acagtttgca tagaattttg tactggagct gaagaaaaga
     5041 tagtatcaac aattaattca gcaataagca aaaagaatat acctttaatt ggagggacgt
     5101 cacaaggcgc taatgataaa ggaatcaaat gcgtatcatt aaatggaaag gtttatttag
     5161 atacatgtgt atatgcatta ataaagaatc taaatggcaa aataaaaact tatagtgaaa
     5221 atatttataa agaaaaaagc ggaaatttta ttgcaactaa agttgatgtt caaaatagaa
     5281 gaattttaga gttaaatgga aaaaaagcag gacaagttta ctgcgaaact ttaggaatta
     5341 caaagaatca aataaatgat tgtgtactta ctaatcctct ggcaagagtg attggaaaag
     5401 aggattttgt aattgctatt aagttagtag atgatgaaga ttcattaaat tgttataagc
     5461 gagtaaatca aaatgatgtt ttaaatatat tagaattaca gaattataaa aaagccatac
     5521 agaatacatt ggatagaata aaagcagatt ttgctaatat ttctttcata ttttcaatag
     5581 attgcatata tagatttttg ttatttgaaa gcatgaattt tacaaaggaa tattgtaata
     5641 ttatgggatc aatagggcag catataggaa ttgttggtga aggagagcaa tatattaatc
     5701 aacatgtcaa tcaaacaatg atatgtgttg tttttgagta gaggagagag tgtgaatata
     5761 atgcgtttct tatttagtag taaaaatgaa gatgaaagca ataaaaatat taagttggaa
     5821 gataaattta aagtaaaaga agaaactaat ttaagcgaag aaatttatcc gattacatat
     5881 tctattaact atttaaagaa tagaacttat gatttaataa aggaagaaag cagtacaaca
     5941 aatgaaataa aaaaaataga agaatcattt ataggagtga aaaataaagc taaagaaata
     6001 aatatatctg tatcaagttt taatgaacat tttaatgata taaaagttgt ttcagatgaa
     6061 ttcagtaata gaatgaataa tatattaaaa tgtgtagaag aatcacaaaa gaaagttatg
     6121 aatttaaaag atagttctaa atcagtagag gaaagtttta aaattattga aaatacattt
     6181 gaacaattta aaaaatcata cgtaacaata aaagagtata caacaagcat tattgatata
     6241 gctgatcaaa cgaatttatt agctttaaat gcatctatag aggcagcaag agcaggtgag
     6301 caaggaaaag gatttgcagt tgttgcagaa gaagtgaagg atttatcagg tgaaattaag
     6361 gaactggtaa atggtgttaa tacaagtatg gataatgttg agaatgatac caagcagcta
     6421 aatatatctc ttcaaaattc acagagtgca ttaaatgaaa gttatgaaaa tgtaaatgat
     6481 acagaagaga tttttgatga aataaaagta aatgtaaatg gcgttagtga tattaatgaa
     6541 aaaatttcga atgctataaa taattctaat ttagaaataa aaaatataag taataatata
     6601 gaacattcaa ctaaatacta tgatagagta acatctgata ttaacaatct aaatactcaa
     6661 cttactcaca agggaataat ttttgaggat attaataatt tcctagaaca gatgaatcca
     6721 ttgataaata gcatagtaga aaaacatgaa tagaaaataa aaaagtgaat aaactaagtt
     6781 tggtaaaaat aagagctaag aattataatc ttggttcttt tttacgttgc tggtatcaaa
     6841 atgaagaagt attatatatt gtagttgatg taatttattg attataaata atttttttat
     6901 tctttagaaa attataaggc agttaaattt gtgtataact tttgaaatta gtagaaaaac
     6961 atagactgag aagcagattt tcttatttta taataaaaat gcaatattac tgtaattaaa
     7021 atagaaaaat ataaaacata ttttaaagta tgtttaattt tatttatatc aaataattaa
     7081 tataaaaagt acatatttaa taagtttagg agtattttat gacaattgga aaaattcaag
     7141 tgaatacatt cgatgtaata acatttgtag gaatggcaat tactcttttt acaagtatat
     7201 taaatttgat tcaaaacaaa aagggactat atataaataa cattacacga tatagggtaa
     7261 catggataaa tacattaaga gttcaaattt caacgttaaa agaattaagt aatataacaa
     7321 atttatatgt tataactagg gaaggagttg ataaagtagc atatagaagg gagttagaaa
     7381 aggttgtatc gttgataaag atgcatttaa atttttgtgg tcaattagat aataaattaa
     7441 tattaaaggt agaagaatta aaatgcataa taaatagtta cttattaatg cattatttta
     7501 gaaatataat taaatctata aatagcgatg atgagattga aaataaattt aatgaagcta
     7561 tagatgtaat aagtgaaaaa aaagtattag atgagctttt aaatatagct cggaatacta
     7621 aaaatataaa aaacactatt agtataaaaa atttaagttt gctagattta agatataaga
     7681 ttaaagcaga atataataat aatacagaac taataatatg tgcagttaaa gagagtgagt
     7741 atgtaataca gagatgggag tataaaatag aaaaaataaa taaagaaatt gatgaaatag
     7801 tacagatata tttgaaatca gaatggtcta gatgtaaaaa agaaactaga ttatggcctt
     7861 ttagtagata taatgaagaa aaagcaataa agcgcttaga aaaggaatat aaggcacaag
     7921 caaaaaaata atatttttca tgtggctaaa gaagaaagat ataaatatca tgcattaaac
     7981 attatatatt gaacaaaata attttataga ttaaaaatag aaattataaa tttaaatatt
     8041 tcactattaa tatagatgaa ataaatacta ttaattagga aggtgttatt atggaagggc
     8101 aaactttaaa taattcaaat attagttctg gagatttaaa atctaatatt actacattac
     8161 caaataacat taatatagaa aatgcaacta ataacaacaa tacaaaagaa tcaataacag
     8221 ctttagttaa acatggtgga gaagtagtag gatacgagtt atcaaatgga caaaagattt
     8281 ctaaagaaca aggtgttcaa ttagctagaa atgatggaat aaatggtgtg actgtagcga
     8341 tttctagaaa aggtgaagag tatttgagga gtttaccaga tcaagatgaa aataataatt
     8401 taaaatcatt gccaataata aatgaataaa aaataatttg atcaatttta agtcttctta
     8461 aattaaggat ataatataat gtataatcat attcttttat gtgtctaatt ataatttgct
     8521 ttagatagtt ttttatatta cttttacact tttttaggta aatgataaaa tcatagataa
     8581 acaatagtgt aatatttaaa atcatattta aattataata catttttagt tgagaataag
     8641 ctaaaaaaag taatataatt atgttaagtg atatatagaa aaatgttagg agatttaata
     8701 atgagtgatt taagtgattt aaaggaatta actaaagcaa aagcagcaag agaaatgcaa
     8761 gaattacaag ataagataat aacaagatta agctctatta aacgagatgg aatagatgaa
     8821 ttaataaaat atcttttaga aagaacagat tattttacag ccccagcatc tacaaaattt
     8881 cattctaatt ttgatggagg attagcactt cattcagata atgttgttga actattaatg
     8941 caaaaaaatc agcagtacaa attaggatta aataatgaca caatatattt aacaggatat
     9001 ttacatgatc tttgtaaatg taatctttat gaaaagacta tgagattaaa aaaggatgaa
     9061 atgacaggaa aatggatagg atacgcatct tatgaatttg atgaaaaaat tcctttaggc
     9121 catggtgaaa aaagtgtaat tttacttcaa caatttgtta agttaacgct ggaagaatgt
     9181 ttgatgataa gatggcatat gggagcttat gtacctaagg atgagtatag ggattataat
     9241 aaggcaatag aaatgtacaa atcagtttta gcatttagta attcagatgc agaagcttca
     9301 catttcttgg aagaagtaag ggaaccagaa ctttatgcaa tagaagaata taatagatat
     9361 gtaaaagaaa aggctatgaa aaaactcaat aattaaaaat aatattaaat ttaataataa
     9421 gtcaaataat aagaaaagat attttagtat aagaatttta caggggggat aaactggctt
     9481 tagatattaa aaagctagtt tatttttata atagattttt taagaaataa tagattgaaa
     9541 tgcttatttg atctgactgt gtttgcttaa taagtttaat taacaacctg ttatgatacg
     9601 aaatattccc ctctgtatga tgaaaagtat agaggggatt ttgtatatta tttaatgtga
     9661 ctaagatata attaaaaaat aacaagtcaa tttgatagaa tattttccat aatccttcat
     9721 tcgcagattg acctaataga ctggctatga ggcgaatcta cctcattacc ttataaaaaa
     9781 tattcatgat agattggact taatattttc ttttatagac gtaaagaaaa aatcgtcata
     9841 aatagtagca atttcagaaa aaatatagta aaatgtacaa tgttgtatga tgacaaatag
     9901 taaactaaaa gttaagtatt tgtaagaaca taaatgttta accgattaag tatattttta
     9961 tagtacagct aaaaaaacta tttatacaag aaaggcagtg atgttagggt tggaaaacaa
    10021 gctgaagtta tacggcttta acaacctcac aaagacactt agctttaaca tctatgatgt
    10081 atgctatgca aaaagtgagc gagagcaaaa ggactatatt gcttatattg atgagcaata
    10141 caattcagaa agacttacaa atattctgtg tgatgtaacg gatattattg gtgcacatgt
    10201 actaaatatt tcaaaacagg attatgatcc acaaggagct agtgtaacta ttttaatatc
    10261 agaagaaacc ttagcagtta aagaaataga tccatcttgt aataaaggtc aaattgatat
    10321 tttgaaaact agggatactg ttgtagcaca tttagataaa agtcatgtaa cagttcatac
    10381 ttatccagaa tatcatccag ataactcaat tgctactttt cgtgtggata ttgatgtatc
    10441 cacttgtgga gaaatctctc ctttaaatgc attaaactac cttataggaa gttttgattc
    10501 agatataata accatagact atcgtgttag gggatttact cgcgatgttg atggtaagaa
    10561 attatttata gatcataaga taacatcaat acaagattat attgatgagg gtacattaaa
    10621 gaaatatgat gctatggata taaatgtata tcaatcaaac atatttcata ctaaaatgtt
    10681 aataaaagaa attgaacttc aaaattatct tttcaataga gatgtttatg aaattaagcc
    10741 taaacaaaga cttgaaatcg aaaataattt aagaaaagaa atgattgaga ttttcagtgg
    10801 aacaaatata tattaatgat agggaggaag cagtatgata gatagagaat cccaatcaaa
    10861 ggcacctatt tatgaagcat taatggaata taaaaaagcc agagttgttc catttgatgt
    10921 accaggtcat aaacaaggac gaggaaatgc tatgcttaga gaatttttgg gcgaacaatg
    10981 tctttcagta gatgtaaatt caatgaaacc acttgataac ctttgccatc cagtatcagt
    11041 tataaaagaa gcagaagagc ttgcagcaga ggcttttggt tctaagcatg catttttgat
    11101 ggttaatgga acaagttcag cagttcaagc gatggttatg agcgtatgta aaaaaggtga
    11161 aaagattata atgccacgta atgttcatag aagtgctatt aatgcattgg taattagtgg
    11221 tgcaatacca gtttatataa acccaggcat aaataaaaaa cttggaatac cgcttggaat
    11281 gtcagttgac gatgttaaaa aagcaattaa agaaaatcca gatgcaaaag ctgtacttgt
    11341 gaataatcca acttattacg gaatttgttc taatttaaaa gaaattacta aattagcaca
    11401 tgaaaatgga atgtatgtgt tggtagatga agctcatgga acacactttt attttggaga
    11461 aaatatgcca atgtcagctg tagaagcagg agctgatatg gcagcaatta gtatgcataa
    11521 gacaggagga tctttaactc aaagttcttt cttattatta aattgtgatt taaatgaagg
    11581 atatgtaaga caaataatta atttaacaca aacaacaagt ggatcatatc ttttaatgtc
    11641 atcacttgat ttagctagaa gagaccttgt tcttaatgga gataagatat ttaagaaagt
    11701 aatagagctt gcagagtatg caagaggtga aataaataag ataggcggat actatgcatt
    11761 ttcaaaagaa cttattgatg gtgatgcaat atatgatttt gatgtgacta aattatctat
    11821 atttactaga gatataggac ttgcgggaat tgaagtgtat gatcttttaa gagatgaata
    11881 tggaatacaa atagaatttg gtgatatagg aaatattctt gcaattattt ctgttggtga
    11941 tcgtaacctt gcaattgaaa gattaatatc ttcattgtca gaaattaaga gactacattc
    12001 aaaagataaa gcaggaatgt ttgatcatga atatataaat ccagaagtag tacttacgcc
    12061 tcaagaagca ttttattcac caaagaaatc tgtaccaatg aatgaaagtg ataaagaaat
    12121 atgtgctgaa tttgtaatgt gctatccacc aggaatacca attctagctc caggagaaag
    12181 aattactaag gaaattttag attatataga ttatgcaaaa gaaaaaggat gttttttaac
    12241 tggaacagag gatattaaaa ttgaaaatat taatatagtt gattcagtta atagttaaca
    12301 gataataatt aatagtttta gataaaaatg tgtcttaagt ttaggcagaa gtttaacttt
    12361 aactattaat tattatctca aacaattaac tggggaagtg aggtaaatat ggaattatgg
    12421 tatacagaac agcatacaga aaatgttcga ttttcaatta aagttgaaaa ggaaatacac
    12481 actgaacaaa ctgaatttca aagaatagat gttttggaag caaaagagtt cggaaaattt
    12541 tttacattag atggattaat gatggtaaca gaaaaagatg aatttattta tcatgatatg
    12601 atagttcatg ttccaatggc aactaaccct aatataaaaa aggttctagt tataggtgct
    12661 ggagatggtg gaactataag agaacttaca agatataaga caatagagaa aatcgatatg
    12721 gttgaaatcg atgaaagagt tgttgaagta tgtaaggaat atttcccaca aacagcatgt
    12781 aaacttgatg atccaagagt taatatattt tttgaagatg gtttgagatt tgtgcgtaat
    12841 aaggaaaatg aatatgactt aataatagta gactcaacag atccatttgg accaggagaa
    12901 ggattattta ctaaggagtt ttatggcaat tgttataaag cgctaaaaga agatggaatt
    12961 ttagttaatc aacatgaaag tccatattat gattttcatg caagagcaat gaaagatgcg
    13021 cataagaaaa tagtaggttt ctttcctgtt attagggtat atcaagcgca tattccaact
    13081 tatccatcag gacattggtt atttggattt gcttcaaaaa aatatgatcc aataaaagat
    13141 ttagatgcag atgcatggaa taaattaggt ataaaaacaa aatactataa tacagacctt
    13201 catgtaggat gttttgcttt acctaattat gtattggaaa tgttagaaaa ttaaacatta
    13261 aaaattaaca gtagataatg aatgataaag gatgaataat taagtttcaa tgaaacttta
    13321 agaataatat taataaaaca gctaaaaaat atttaagtta taattattaa tttttcatcc
    13381 ttgatcattc ataaaaaaga attggaggaa ttaaaaatgg gaaaagcttt aattattggt
    13441 gctggcggtg ttgctagtgt tgctattcac aagtgttgtc aaaattcaga agtatttgag
    13501 gagatttgta tagctagtag aactttatca aaatgtgatg ctataaaatc gtcactagaa
    13561 ggaaagacta aaactaaaat acaaacagct caagtagatg ctgataatgt tccagaatta
    13621 gtagcactta ttaataaatt taaaccagaa gttgtaataa atcttgcact tccttatcaa
    13681 gatttaacaa ttatggatgc ttgtttagaa acaaaggttc attatataga tacagctaac
    13741 tatgaaccac ttgatacagc taaatttgaa tataaatggc aatgggcata tagagaaaag
    13801 tttgagaaag caggaataac tgcattactt ggtactggtt ttgatccagg tgttacagga
    13861 gtatttagtg cttatgctca aaaacattat tttgatgaaa taaactatat agatatatta
    13921 gatgctaatg caggtgatca tggatatcct tttgcaacta atttcaatcc agaaattaat
    13981 atacgtgaaa tcacagctaa tggtagctat tgggaaaatg gaaaatggat agaaacagaa
    14041 cctcttgaaa taaagagagt ttatgatttc cctgaaatag gaccaaaaga tatgtactta
    14101 cttcaccatg aagagttaga atctttaggc ttaaacatta aaggaattaa gagaatcaga
    14161 ttctggatga cattctcaca aaaatatata acacatttga atgtgcttga aaatgttgga
    14221 atgacttcaa ttgaaccaat tgaatttgaa ggaaagcaaa tagttcctct acaattccta
    14281 aaagcagttt taccagatcc agcatcactt ggtccaagaa caaagggtaa aactaatata
    14341 ggatgcatat tccaaggtaa gaaagatgga aaagataaaa cttactatgt atacaatgtt
    14401 tgtgaccatg aagaatgtta taaagaagtt ggttctcaag caatatcata tacaacaggt
    14461 gttccagcta tgattggagc aagtttagta atgaaaggtt tgtggaaaaa gccaggagta
    14521 tataatgtag aagagtttga tccagatcca ttcatggaag aattaaataa atggggatta
    14581 ccatggaaag aaagctttga tccaacttta gttgaataag caacatgtaa tttgaattta
    14641 tgtgatgact aaccgaaata agtaatatga tgtgttacgg tttctctgga atttagatgg
    14701 gtgattctat gataagaagt tgtacccaaa aagctagcct caaagacacg ctttgaacta
    14761 gctttttgga acaacttttt gtcaagaatc actaccatct aaattccaat gaaacactcc
    14821 acacatcata ttacttattt ctctgtaagt aggcacattc aaagaaatgt cagattcatt
    14881 tcttagttta cttttcaact ggtgtgtcaa ttaaataggt tcatccgtga attttgtgat
    14941 gttgaatttt aaaatactaa tttacatata ttaaaacaag tattttcaat aactaattaa
    15001 gattaactat cagcaatcac aaaatatctt gatgaaccaa aaaatataat tgaaaaaagg
    15061 actgatgatt caatgaaaga tatagatata agtaaattac catcaccatg ttatttggtt
    15121 gatgaaagac ttcttaagaa gaatttagaa gttttagatt atgttcaaaa ggaaacagga
    15181 gctaatatta ttcttgcaac aaaatcattc tcaatgtatt caacattccc gttgattgga
    15241 aagtacttaa agggagttac ttcaagttct ttacatgaag ctagacttgg atatgaagaa
    15301 atggggaagg aagtacatat tttttcgcct gcatatagag atgatgagtt tgatgatata
    15361 atgaaatata gtgatcatat tgtatttaat tcattcagtc aattcaaaaa atatagagat
    15421 aaaattaaaa attttactgg aaagaaaatt gaatgcggta ttcgtattaa cccagaatat
    15481 tctgaaatag aaacagatat atataatcca tgttttaaaa attcaagaat gggagttact
    15541 ttagataatt ttgaagaaga tgagcttgaa ggtatagatg gtttacattt ccatacaatg
    15601 tgtgaacaaa actctgatac acttgcgcgt acaataaaag tggtagatga aaagtttgga
    15661 aagtacataa aaaaaatgaa atggattaac ttcggtggtg gtcatcatat tactagagaa
    15721 gattatgata tagaaacact aattaaatct attaatttca ttaaagataa gtatggagta
    15781 aaagtatatc ttgaaccagg tgaagctatc gctttaaatg caggatttct tgtgtcaaca
    15841 gttttagata caatgaaaaa tggaatggat atagcaatac tagatacatc agcagaatgt
    15901 catatgccag atgtacttgc aatgccatat agacctaata taataggtgc tggaaagcca
    15961 aatgaatttg aatttactta tagatttgga ggaccaactt gccttgctgg tgatattata
    16021 ggtgattatt catttaaaga acctttaaag ccaggggaca aattagtatt ctgtgatatg
    16081 gctatttatt caatggttaa aaacaatact ttcaatggag tgaatcttcc tgctattgta
    16141 aagtatagtg aagaaaaagg aattgaaata ataaaacaat ttggatatga agattttaaa
    16201 tctagattat aatatttaat aaattaataa ttagagacat gaactagagt atatatatgt
    16261 agtagtttta gagaataata atttctgaga ctactatttt tttatgcggc taaaatcata
    16321 aaaaggattt gattaaaatg atattctgca atatatttta aatctatata atataattta
    16381 gtatgaagcg tacaaaatga ggggtaaaag gaaaattacc tatattattt ctttttattc
    16441 cttattttgt acgtttaaag gaaaaatggt taacatttat gtataattat gagaaaatag
    16501 caacgtataa agattatcta aaaagaaaaa taatatttat gaaaaagaaa ttaattaaag
    16561 gattaagtgt atttttaatt aaggataatt ttagctttga tatagaaaat tagtgtgcta
    16621 ggaatttaaa aataatgatg aatataaatt gtttattaaa atagaccaag attttataag
    16681 tcaactcaaa taagagttat taaaaaacta gttttattta taaaaaattc aaaaaagagg
    16741 ctgtcttgaa atagatatca aatttctatt ttgaaacagc ctattttaag tgtaaaaaat
    16801 ttcttggtga agtaaatgaa cttgttattt ttttaaatgt gcttaaatta agaataagct
    16861 caaagattag aattaattta gtgtaaaagt ggagggaagg atgtatttat gaaagatgat
    16921 tttatatcat atgaaaattt aagaatatca acttatgaag tgaaatttgt aaaagaaatg
    16981 catatagaaa attgtttgaa caaccatgct actttgaatc ttatatgtat tttagatgac
    17041 gaaatgaaag ataattgtgt acaagataca gatcaagaaa ctccaataga agtgttttat
    17101 gaaaaggaag aagcacattt ctctttattt aatggtgttg ttacaaaagt aaaggttaag
    17161 gtaattaatt acgtttatac attatttata gaagctaaaa gttttgatta taaaatggat
    17221 attgaaaaga aaaaaagaga ttttcaaaat ataaatatga gtactcatga acttatagat
    17281 gaggtaatga aatcatatcc taacgctaac tataatataa acattcctaa tgaaccaatt
    17341 ggagaattta tacttcaata taatgaaaca gattatgaat ttttaaagcg tatagtatct
    17401 agatataatc aaactcttat aagtgaaatg gaacttaaaa acatttattt atattttgga
    17461 actccagaaa aacatgtgga gctaaaaaca caaatagtaa attatacaat ctcaaaaaca
    17521 gtacatgaat ataatgatgt aaaaaataat gatgtgtttg atgttttgga aacagatttt
    17581 attacttata aaataaggac tcaagaaata ttgaatcttg gagaaaactt tgattttaaa
    17641 ggtagacaat tttatattta taaagcggta tatacaatgg aggaaggtaa tttagagaat
    17701 atatatgaat taagagcaaa aggtggtctt agatcaaaac gtttatttaa tatgaacgtt
    17761 ataggaatat cgattaatgg atctatatta gaagtaaaga gagatagagt aaaagttcaa
    17821 ttagaaatca acagtgatac tgatgcgtct atagcatatt ggttcccata ttctacagtt
    17881 gcagcatcaa aagatggtgg aggatggtat tgtatgcctg aagttggaga aaggataaga
    17941 ttatattgtc caacaaagga tgaaagtaag gcatttgtta taaatgcaat agatactcat
    18001 gaagcgaaat ctggaggggg ggccaatgaa gatagaatgt ctaatccaga taataaatct
    18061 ttaaagacag atgcaggtca agaagttaaa ttcacaccca atggagtatc gatagaatgt
    18121 agcggaggac aagcggccgt aaatttaaat aaagatggaa ctatagaaat tacagggcaa
    18181 aagaatataa atattgcttg tgctcagaat ctttcactaa aagcaggaaa tgaaatgaca
    18241 attagtgcac aaaagagtgt ggatattttg tgtgaatcag gaagcaacgt tatattatca
    18301 gaagcagatg aaatattagt caatggaact agggttcaga acaacggata agaaggaggc
    18361 attaattatt atgaatatag atgaaaaaat agcaaaatta aaaatgcagc aaaggcttga
    18421 aaaggaaaat gaattaaaaa aagagtcaca aaaagaagag atctcttcta tagaagaaga
    18481 gattaccctt aaagaagtta ttgaacaaat aagtgaaggg gcattaagga taaataatac
    18541 taactttaaa tttgtaaaaa aagtgttctt aaatggaaag ttagaaatac caatgccatt
    18601 agcatatttt gaagaaagag taaatactga gaagaatact actttagtta atgataataa
    18661 tggtgtaagt tttactttag cttatgtaga taaaggtgtt caaaagcaaa gctttgctaa
    18721 gtttaaaaaa ggtatggaaa aaaactttaa agatatagat ctttatttag aatggatgga
    18781 agaaggggaa gtaggagagg gtgcttctaa agtatcttat ggaacatata agacgcctac
    18841 aggaaaaggt caaatttata atctcatatt ctacagagag tataaaggaa ctttaataat
    18901 tggaaattat aattgttttg aaaaagatat aaaaacatgg gggcttttaa taaaagcaag
    18961 cataatgctt atgaaagtaa gataaagata agctaaataa ggcatatgaa aataaataac
    19021 tagtccaaaa tgtcatgatt attttttatt gggaagtaag gagatttgtc tcatagcgga
    19081 ctattagatt ttggaaggtg ccttaaaggg agggagtaaa aaagtggaag gaaatcaaat
    19141 tggtgaagcg attaactatg agaaagtccg agttaatggt tacaatttag aatcaattaa
    19201 aagcttgaaa ttagaaacta atataaatga acatactgtc ttaaatctaa caggcatttt
    19261 aaaaaacgaa gttaaagata gtgatattgc ttcaacgact aataataaaa ctatagaggt
    19321 ttattatgta gaaaatgaaa gtacaacatt attttatgga attgttacta acatagaaat
    19381 aaacgtaaaa tttgacgtat atatgttaaa tattgaagca aaaagtatgt catatttaat
    19441 ggatatacaa ttaaaatcaa aatcttttca aaacatatca atgacaactc atactcttat
    19501 aaagtctata atgcaaaatt atagtgattc taactatatt attaatatac ctgatgagga
    19561 agtagaagaa ctgcttgtac aatacgaaga aacagactgg gagtttttaa aaaggatagc
    19621 atctaaatat aatcaaggct tatttccagt tatggaaggt aagaaaatac aatttgtagt
    19681 ggcagtacca gaacagtcta aagaattgaa atcagaaaat gttaattata aaatacgtaa
    19741 agatttagaa cattatgaat atatgcatca aaattattta ccagatgcaa gtgaagtaga
    19801 ttacattact tatgagatgg aaagctatgt ggtattaaaa cttggagata atatacaatt
    19861 tcagggacaa aatttttatg tatatcatgg aagttatgaa ataaaagatg gtactttaat
    19921 taataactat aaattaagaa ttaaaaatgg attaagacag aaaagaatat ttaatacaaa
    19981 agttatcgga agttcaattg atgggaaaat aatacaagtt caaagtgact tagtgagaat
    20041 tcatctagaa atagatgaag ttcaagatca aggaacagct tattggttca agttttctac
    20101 tatgtcagca tcaagcgatg gtagtggatg gtattgtatg ccagagatgg gggatagtgt
    20161 gaaagtatat tttcctacta aagatgaaga tgaagcattt gcagttagtg cagtaagtgg
    20221 atatgaacaa ggagtaggtg aatcagaaga tagaatggga aatccagata ataagtattt
    20281 gagaactact catgataagc aggtaaagct tacacctgat gggattttta tttcctgtga
    20341 cagtggacag gcagacatga gtcttacaag tgatggaaca cttagtatta caagtcaaaa
    20401 taacatagat attaatgcag aacaaaacat taaaattgaa gctcaaaaaa gttttttagt
    20461 aagtgcaaaa caaggcataa attttgcttg tgacaaaggt ggaggcttag aatttgataa
    20521 ttcaggaaat ataaaagaaa agggcacaaa agttaataac aattaaaaaa ttatttattt
    20581 gtgtgtacct aaacccaaaa gtataagtcc taataagaaa gaagggattt tatgaataga
    20641 gaagagtctt taaaagagtt taaagaaaaa atagtcaaag ctttaggtga agaaagtata
    20701 gaaacttttg aaaaaaattt taaagataat gaagaaaaag ttaaaggaat gttaataaac
    20761 ggaatgagaa ccttaattaa cagagcaaag aacattaaag agaacaatag tgaaaataaa
    20821 atagcagttt ttcaatttga acttcttaga attaatattt taaacgaatc ttataagata
    20881 ttaattcatg gatataattc ctcttggtat ttggatccta agcctatata tgaagaaata
    20941 gatttaagtt ttttatttga accttttatt aaagttaagg aaaaattgat taaagagaaa
    21001 agaatttata tgggcaaagt taataattat gacatacaaa aaatgatatt tgaacttgta
    21061 gtgaaatgtt ataagaatat gtcaaagaca ataaggaatt ggttttggaa tttagatgaa
    21121 gaggaatgga ttaacgaaag ggtaatagaa gatttttata tagtaaagtg gagtgaatat
    21181 caaggaagaa gtgaaactct ctttgctatg gacaatagag aaaagaatat aaaagaactt
    21241 ttagaattga aagagcagcc tgaagaaaaa ttaccttttg tatacactgt ctggaaaaac
    21301 agtattttag aagatggagt tttagcaaag caaaacatgt tatttattaa ttttaaaggc
    21361 agcaatctta aagatataga tttttcagaa tgtaacatag taagaggtca gtttaaggat
    21421 acagaagtaa aaagatgtac acttgtgaaa tgcaatttaa tagggtcatc ttttcaaaat
    21481 tctaaaatcg aagattctga ttttagcaat ggaaattgca caggtgtgga ttttaggcaa
    21541 gcagaactta gatatgtaaa tttttcaaat tcaaatctta aaaagtctaa ttttataaat
    21601 gcaaagttta aaaatgtatc ttttgaagga gcagatttag aagatgcagt atttagtgct
    21661 aaagatatac cttttattaa tttaacttca gagcagcttc aaactatata tatagatgga
    21721 ggcgaagaaa gatgaaatac tttgttttaa agcaagatag aaatttagaa aatgcaattg
    21781 aaatagaagg ctttaataac agccaaaaga tgacattact taaggcagat gaagataagt
    21841 ataaagattc taccaatgta ctcgtacatg gaaatgaaaa tagcatttat ccagatttaa
    21901 tacaagcacc agtgcttata atttcagatg agcttcataa actttttaaa ttatatgaaa
    21961 acactgtagt ttataaaata gcagtatttt cagatttaaa aaggaagaag cagaaagtat
    22021 atagattagt tcttccagaa ttattagatg cattaagtga taagtctgtt ttctttaaaa
    22081 atggctggat agataagata gtattagatg atgagaaaat tggtgactac aatatatttc
    22141 aaatcaaagc aggagtagat tattacttta tagtgtctct tgatgtagtg gaaagtatgc
    22201 ttaaaagagg attatttgta ggaattaaat ttgaggaagt tgaggtgata taagatggca
    22261 agtgaaaatg aagaaaaata tggtgttata gctggaacag caataaatga agttgaaaaa
    22321 ggcgtaaaag gtacagttaa ctcagtaaag caaattggga ccatggctca gagagccgga
    22381 ggttttgcac ttagagatgc tacaaatgaa tggaaatggc tcaacttatc accagaagaa
    22441 aaagcagctg agaaagaaaa agaaaagcaa gcagcagagg aggcaaaagc agaagcagat
    22501 aaagcagacg cagataaagc aaaggcagaa gatgatgaaa aggaaaggat aaaaaatctt
    22561 gaaaaaagct atatagttca tacagcagct attacttgta gttgtgcgct tcatgaaagt
    22621 tatgttgtag ttccagaagg ccatggggaa tttatacatg gaattcctca gttaaatata
    22681 ggagatagta agccagaaat aaatataaga agttttggaa tatgtaaaag tcctcaaaat
    22741 ccaagtgtac aagaaaatgc taaaaaaata gcagatgagg ttaaaaatag acctaaaggc
    22801 tttacggaaa aagttatgga tttcttttca aaaccaccag ctgaagatgt gggtaaagat
    22861 ttactagaac aatgtgtagg agaatgtact ccaataatag ctacagagtg gatagatgga
    22921 aaagaagatg ttcttgttga tggtaaacct gcattacttg gaaaatgtaa acttacatgt
    22981 ttatatggcg gagaaattaa attatataca agtggacaaa gggaataaaa atctaattag
    23041 aattataaat gaaaaggagg tattatagaa tgctgacata taaaagtcta aaaatagaga
    23101 taccttatga tgcagttcaa attgaagata tagatatatt acaacctata aatgatcatg
    23161 catatttaaa gattaaactt ttgatagaag aaggaaaaat aatagaatat ataaataaaa
    23221 atgttagcga agaaaaagtg actgtatcta gaattgaaga taacggtgaa gaaactaaat
    23281 tatttgtagg aaagataaat aaagttttta tgtcatatga aggcagcgtt caaattatgg
    23341 aactagaagc tgtttcatat acaaaagatt ttgatattaa gaaaaatagc agaacttttt
    23401 gtaatttagc aatgacttat caagaagtta taacaaaggt tttagaaagg tatagtaata
    23461 aagcatttac agacaacata acgaacggac aagcaatagg agaatttatt cttcaatatg
    23521 aagaaagtga ttgggaattt ttaaagagaa tagctagtca ttttaatggt gtactacttc
    23581 cagaagctac tgaagattat ggaagatttt attttggaat accggattta aataacaata
    23641 aagagataaa catagatgat tatgaagtag taaaggatat agatagcttt aataagttag
    23701 aagctatggg ctttgaagaa aattttcttc aggaatatac aacttgggat attgtaagtc
    23761 caattaaatt aatgcttggt gagaaagttt tatttaataa agttaaatgt gtagtagcaa
    23821 aaattcatac tgaagtatat aaggaagaaa ttagaacaat atatacttta gggattcaaa
    23881 gagggcttag aaccacctat agagtaaatc acaagatttt tggaatgagt attcctgcaa
    23941 cagttaaaga tgtaaaagga aataatatga gtgttcactt tgaaatagat tcagaagatg
    24001 aagagtgctc aaatcaaaag tactttacat atgcaataga aagtagtgca tggtactgta
    24061 tgccagagaa gggaagccaa gttcatatat actttccaac taatgaagaa aaagaagcaa
    24121 ttgcagttca tgcagtaaga attggagcag gttcagctaa aactcaaaat cctgatatta
    24181 agtcattttc tcatacaggt ggaagtgaaa tgaaactaac accaagtgat atgaattttt
    24241 caccaggagg tggtggagta agtttaaact tagctcaatc aggggatgtc tctttaaatg
    24301 gacaaaatat aaatcttaca gctaatgaaa acttagagct tggaatgaga gatggaagtg
    24361 gagatgtgcc ggcttttagg ccacaaaata tagatatttc ggctaagagt aaaatagaaa
    24421 tagcaaaggg tggtattggg attcaaattg ctgatgagac atttttaaag gcatctgtaa
    24481 ttaaatacga aggaagtatt aaggatccag tagaaatacc agatgaaata gctcatagga
    24541 atgatgagga tgcagataat atagaaaaaa taaataacca agctaaagta aatatggaag
    24601 caaaagttga tgaagctaaa agtaaaattg gttttggagt agttgcttca gtaattggag
    24661 cagttgcagt tggagttggg gttgccgtat ttgcagcagc tacagttgca acgggagggt
    24721 taactcttgc tatagctgga gttgcagtgg catctggtgt tacagctatg gcagtaggtg
    24781 catctgaaac cagtgagggg ctgtcgaatt atagtaaatc ccagagtggt gattactcga
    24841 aatcctataa ttttatgcgg gatactgtct gtggtggaaa tgaaggtctt tataatgttg
    24901 taaaatatgg atctgttatg attgcaggaa taagtactgc attgttaaca ggtggagcat
    24961 ctttacatga aatggcagtt acaatgggga aaataggact tgattcaggc ataaatacag
    25021 gattcgaatt acttgcagat tacgcagatg atggaaagat tgataatggt tgggaaagtt
    25081 atgctgaatc gtttgcttta aattgtggat taagcggtgg aggtacaact gcatttaacg
    25141 ggttgaataa gctggaaaaa attaagaagt tggaatgcgg aacattaggc aagataaggt
    25201 ttggaacaga tgttgcagta gatatggcag ggcagctggc aactacaggt gatgcaaatt
    25261 taacaactac tcttttaagg aaatatataa gcaataaagt atgtttttct gacccagtag
    25321 atggagcaac aggaagtttg tatattccag caacagatat agtactacca gatattcatg
    25381 aagaatttaa gatcgaaaga aaatatgaat cagtaaataa tagattagga cttcttggta
    25441 ttggatggac aacaagtttt gaaactttcg ttgaaattga aggtgaaaaa ataaatgtac
    25501 tttgcaccga tggtcatgta gaaagctttt atttaattga agatgaatgg gtaaatgata
    25561 aaggcggagc taagatttat gatttaaaac aagaaaatga ttattggata tttaaaactg
    25621 cttttgatag gaaaacttat aagtacaata gatcaggaaa gttaataaat ataactgata
    25681 agcatagtaa taaagtttca ttaacttata taggagaaaa tattgaaact ttaacaacat
    25741 tctcaaatta taaattatca tttacttata aagatggaaa agtaattgaa ataaaagatg
    25801 agcttggaag aacagttcaa tataaatata ctggaaatta tttaacagct gttatccatg
    25861 ttgatcaagg aataacaaga tatacctacg atgaaaaagg atatataagc agcataacag
    25921 accaaaatgg aaatacttat acgaaaaatt tctttgataa aaaaggaaga gtaatccgtc
    25981 aggacttccc aaatgatgat acatgtaaaa taacttatga tgattcagaa aaagaagtaa
    26041 cattctatta tactaagagt aaacgaacag aaaaaacaag atttaataaa gagggtttaa
    26101 ttacacattt attttatgaa gatggaagta cagaagaata taaatatgat gaatatcaaa
    26161 ataagattta tataaaggat agaaatggat ttgaaacaaa tagagtttat ga
//
