LOCUS       NZ_LR134477.1          14591 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_LR134477.1 Actinomyces viscosus strain NCTC10951 chromosome 1,
            complete sequence.
ACCESSION   NZ_LR134477
VERSION     NZ_LR134477.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-13 23:29:38
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 273
            Orig. end    :: 14864
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..357
                     /locus_tag="ctg1_1"
                     /transl_table=11
                     /translation="MPWPDPGAALYPELAELGSSREALAPVSGDALTQVRIALAVWTAV
                     RSWACSLYLRHADVQMPAARKARALTRPRVTQVSKGPGARRTPRLREMTEADLEEIARL
                     EASCSAPRHGAGTC"
     protocluster    1..14591
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[2740:5089]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2468..4816
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..14591
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14591
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             636..884
                     /locus_tag="ctg1_2"
                     /transl_table=11
                     /translation="MLAELVDTARKAGCPDVLLEVRQSNQTAPGDLRQARVRPIGRRRR
                     YYQAPPEDAVVMRLTLRSAWTLSERPRSVSRVRAEPS"
     CDS             1695..2039
                     /locus_tag="ctg1_3"
                     /transl_table=11
                     /translation="VHGRAYLNMYYGFQLWWVWLIYAIALVSLCLHVWHGVWSALQTLG
                     AVRGGTIPFIRLIAFVVAFALFAGFMIVPTAILFGYVDAPMSAADYYPQFCDAIGSSAE
                     HFAECVAATH"
     CDS             2468..3691
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 116.9; E-value:
                     3.8e-36)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_4"
                     /sec_met_domain="FAD_binding_2 (E-value: 1.8e-34, bitscore:
                     116.9, seeds: 62, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VRGPGRPFAREYGGLLDNRSFGGVQVSRTFYARGQTGQQLLIGAY
                     QALERQVHAGTVKEFRRHEMVELILVDGRARGIVTRDMVSGEIETHLADAVVLASGGYG
                     NVFFLSTNAMGCNATAIWRAHRKGAYFANPCYTQIHPTCIPQSGDFQSKLTLMSESLRN
                     DGRIWVPKRAEDCDKDPRDIPEEARDYYLERIYPAFGNLVPRDIASRQAKNMCDEGRGV
                     GPAIKERDANGNERMMRRGVYLDFSEAIGRLGKDAVSARYGNLFEMYQRITGDDPYEVP
                     MRIYPAVHYTMGGLWVDYDLESNVPGLYIAGEANFSDHGAQPPGRLGAHAGPGRRLLRP
                     ARHHERLPGGHAAPGQGRPERPGDRRGQALRRGAGRPPHGPARNPQRGRLPHGPGTHHV
                     GVLRHGAA"
     CDS             3642..4049
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_5"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.5e-35,
                     bitscore: 119.5, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALGRIMWEYCGMERRDAGLRDAIKQIRALKEEFWRDARITGQAD
                     ELNQALEKAGRLLDFFELAELMCIDALHRRESCGGHFRAESQTPEGEAMRHDDEFLYVA
                     AWEWGGENRPPILHKEDLVYKDIELKQRSYK"
     CDS             4046..4816
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_6"
                     /sec_met_domain="Fer4 (E-value: 4.2e-06, bitscore: 23.8,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 1.1e-06, bitscore: 25.9,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_3 (E-value: 3.7e-25, bitscore: 85.5,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 2.9e-11, bitscore: 41.1,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 1.6e-05, bitscore: 22.6,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VNIKLKIWRQKNKDSKGHFEEYAMSGIEEHMSFLEVLDLLNEQLF
                     AEGKEPVAFDSDCREGICGQCGVVINGQAHGPIRSTTCQLHMRHLAEDPSFKDGSTITI
                     EPWRSTGFPVLRDLIVDRSALDRIVQAGGYISVNTGGAPEAHSVPVQKEKADAAFEAAA
                     CIGCGACVAACPNASAMLFTGAKISHLGLLPQGQPERLARVVSMLNQHDAEGFGGCTNI
                     GECAAVCPKSVPLEVISRLNRDLGHALWKGQHAH"
     CDS             complement(4916..5449)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_7"
                     /sec_met_domain="HAD_2 (E-value: 5.4e-13, bitscore: 46.8,
                     seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSERFDEIMAYSPGRTGIDTIRRFLPELASEEHDAIHERFAQEEI
                     VRTAGRMAEIPGAAALVTALIDAGVPLALVTSAPIELMRVRMQEAGVPIPAVAVSADDV
                     ARGKPDPGAYLKAAELLDVPISSCLVLEDAASGYTAAQRAGAQILLVGDGVPEADPQVP
                     RIPDFTGVTFTVVG"
     CDS             complement(5474..5614)
                     /locus_tag="ctg1_8"
                     /transl_table=11
                     /translation="MTVHPAVQLMSSSGPAGEPVRLARAEAILCDMDGTLVDSSAVVES
                     M"
     CDS             complement(5706..6053)
                     /locus_tag="ctg1_9"
                     /transl_table=11
                     /translation="VDRLLGNTGIVRNRAKILATIDNARATLRLREAGDVDGGLAGLVW
                     SYQPESTPRPRRLEDVPTQSPQSAALSRDLKRRGFRFVGPTTMHALMEAIGIIDTHLVG
                     SHRRGSSGVWA"
     CDS             6992..7483
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M22"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_10"
                     /sec_met_domain="Peptidase_M22 (E-value: 5.7e-27, bitscore:
                     92.5, seeds: 111, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VDRLSQEGDRSAIRFPRGLAAGKDKERHRYDFSFSGLKTAVARYV
                     ESLEDAGQEVPGADVCAAFSEAVNDSLTAKAVQACLDTGCDTLVVGGGYSANSRLRSLA
                     AERCEAAGITLRLPPLRFCTDNGAQIAALGSAAVRAGVAPSPMDFAPDSGMPLDVSVVH
                     "
     CDS             8998..9471
                     /locus_tag="ctg1_11"
                     /transl_table=11
                     /translation="VLTYSVSMRGMKEKTVEMDRKLAAISSTMVEFVSGIGVVKAFGRV
                     GRAHSAYLTAADEFSAFYRAWAMPLVTVTCLSFTWVSIPVLLLVNLGDGALLIHAGAVT
                     LPQVLATTLVALGPARRAHHHRLDLLVLPDGRSGGSAPVRGPRHPRSARCRPS"
     CDS             9658..10503
                     /locus_tag="ctg1_12"
                     /transl_table=11
                     /translation="VRIGGVDLRDMDETTLYSTVSFVLQDAQLLGTTVRENIALGRPDA
                     DLDQVRAAARVARIDEEIMALPDGYDTVLGQDTALSGGQEQRIAIARAILLDTPVILLD
                     EATAMADPESEAEIQQALSALVKERTVLVIAHRPAAVRGADRIAVMERGRIVASGTHDD
                     LVNEPHYRALLRQTGELDGAAGPIGESSVTGADGPSLADEPGGEASGAPSPDSVEQAVE
                     QVPDRSRSVPPVPTPAAGASGAVRSLLARFRRLMLDSSGGQTRTSLVLGAANGVASGPH
                     "
     CDS             10801..11145
                     /locus_tag="ctg1_13"
                     /transl_table=11
                     /translation="MYMLTSTTAACVVVWAGSWAWDWRLGLLLTVAAPLFAELVRAARR
                     LMDHGKSISEPAERELATRVVEIARCQGPALVPGRHRLQPPEGRLRTTASVPHGAPCSG
                     RPPVTSSTVH"
     CDS             complement(11420..11521)
                     /locus_tag="ctg1_14"
                     /transl_table=11
                     /translation="MVVLPLPEGPTIAHMVRAGTFIDTPARTGWSAR"
     misc_feature    complement(11510..11512)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="gutsmash"
     CDS             11570..11719
                     /locus_tag="ctg1_15"
                     /transl_table=11
                     /translation="VGGTDVRDMPTAQLMEQLSMVFQDVYLFDDTLDANIHIGDPAADD
                     DQVR"
     CDS             11783..12064
                     /locus_tag="ctg1_16"
                     /transl_table=11
                     /translation="VGEGGRALSGGERQRVSIARALLKRAPIVLLDEATSALDAENEAN
                     IVAAMQELRRTSTLIVIAHKLETIAAADQVIVLDDAGHVAQHGRHEDL"
     CDS             complement(12254..12478)
                     /locus_tag="ctg1_17"
                     /transl_table=11
                     /translation="VKKLSWQQAHRRIWISTAHMYGSWSMTVCKVVVALDEKQVVLPGA
                     VAQGIFRKRTEARAELVVERINAMDPMNG"
     CDS             12686..13093
                     /locus_tag="ctg1_18"
                     /transl_table=11
                     /translation="VKDRTIASVAASYDPQAQTVGNWVAKYRKDRATDQDRKKASESAE
                     IAKLRAEKQGAVSGERVPEKSCGLLREGTTVTERYGLINREEGHYPTSSMCRWSGVSRS
                     GCYSWRDRPQCATAIGREVLATMIKDAFADS"
     CDS             13591..13869
                     /locus_tag="ctg1_19"
                     /transl_table=11
                     /translation="MSCASGPRGRALEALADPARAKGAIRRIAEELGVHPEALRSWVKK
                     AQVDGGLRPGTTTDEAQRIKELEKGGPRAAKSQRDPEECVGFFRGGV"
     CDS             14151..14591
                     /locus_tag="ctg1_20"
                     /transl_table=11
                     /translation="VARCTVERLMGDLGLHGVRRAKSPRTTRSAPPDRCPADLVKRHFS
                     AFRPNELWVADITYVRTFSGWVYVAFVTDVFSRRIVGWQTTYRPVCTDLALDALKMAVW
                     QRKRTGADLSGLVHHLRPRRAVPVHPLRAGPIRLRGSRLCRL"
ORIGIN
        1 atgccgtggc cggatccggg cgccgccctc tatcccgagc tggccgagct gggctcctcc
       61 cgcgaggcgc tcgctccggt ctccggcgat gccctgaccc aggtgcgcat cgccctggcc
      121 gtctggaccg cggtgaggag ctgggcgtgc agcctctacc tgcgccacgc ggacgtgcag
      181 atgcccgccg cgcgcaaagc gcgtgcgctg acccggcccc gggtgactca ggtgtccaag
      241 ggaccgggag cacggcggac gcccaggctg cgggagatga ccgaggcgga cctggaggag
      301 atcgcccggc tcgaggcgag ctgttcggcg ccgaggcatg gagccgggac ctgctgaccg
      361 ctgagctgga ggcctcccgg gggccccggg ccgaccgccg ctacgtcgtc gtcgagactg
      421 atgccgagcc tggtgtcgag ccagacggtg ccggcgagga acacggcgcg gatcatgccg
      481 acagccgcgt ggggctccgg gctcgagcag gaaccgggcc gggggggacg cctcctgggc
      541 tatgccggcc tctaccacgc cggtggtctg accagcgccg acctgctgac catcgccacc
      601 gtcccggccg cacgcgggcg gggctggcct cgggcatgct cgccgagctc gtggacaccg
      661 cccggaaggc gggctgtccc gacgtcctgc tggaggtgcg ccagtcgaat cagaccgccc
      721 caggggatct acgccaggca cgggttcgtc ccatcggcag acgccgccgc tactatcagg
      781 cgccgcccga ggacgccgtg gtcatgcggc tgacgctgcg cagcgcctgg accctctcgg
      841 agcggccgag gtcagtgagt cgagtccggg ctgagccgag ctgagtcggg ctgggccgag
      901 cgcgcggctc tgcccggccg aaagatccgc acgcccgacc gggaggattg cgccgggggt
      961 gaagaagcag ataggcacgg tgttggccgg caataaatac ggctttctgc ggtggaggcc
     1021 tcgagtgtcc gaggcctcac agatttgtct gacaccccta tgacgaaaag gcggcctcgg
     1081 acggtggcgt cagcaaattc cgcagcgttg aatccgacgt tgaggccttc cgaaatcccc
     1141 gagattctgc ggattgtcgg cgtatcggtg ctggtggcgg cacagatggt gccgaggtgg
     1201 cttcaatccc ggctagcctt ttgccgtggc caaaacatct gctccttccc tgaagaggcg
     1261 gaccgccttc tccacgaccg tcttcatgaa gcgcatgatg gcgatctcgg ggctggtgtt
     1321 cctgttcttc gtcctcttcc acgcctatgg caacctccac tacttcgagg gtgaggtcgc
     1381 ctacgatcac tacgccgtgt tcctgcgcgc gatcctcgta ccaatcctgc cctacgaggg
     1441 tttcctgtgg atcctccgcc tggcgctcat ggcctgcctc ctggctcacg ccggcagcgc
     1501 cttccacctg tgggtgcgca acaagcgggc ccgtggcaac gacaagtacg ccgtcaagaa
     1561 gcccggcgcc gagtacttcg cctcccgcta cgccatgcgc accatgcgct ggggcggcgt
     1621 catcctcctg ctgttcatca tctggcacat cctgcagttc acccaccctg tcactgacgc
     1681 cggggggcca gtacgtgcac ggacgcgcct acctcaacat gtactacggc ttccagctgt
     1741 ggtgggtgtg gctcatctac gcgatcgcgc tggtgtccct gtgcctgcac gtgtggcacg
     1801 gcgtgtggtc ggccctgcag acgctgggtg cggtgcgagg aggcaccatc cccttcatcc
     1861 ggctgatcgc cttcgtggtg gccttcgcgc tgttcgccgg cttcatgatc gttccgacgg
     1921 cgatcctctt cggctatgtc gacgccccca tgtccgctgc cgactactac ccgcagttct
     1981 gtgatgcgat cggctcctcc gccgagcact tcgccgagtg tgttgcggcg acccactgag
     2041 agtgaacgac tatgactgaa ctcatcgacg gcctgtacta cgagggcgag aagatcgccg
     2101 acaccaaggc cccccacccg tcccgatcga caggcgctgg gagcagcgca agttcgaggc
     2161 caagctcgtc aaccccgcca accgccgcaa gctggacatc atcgtcgtcg gctccggcct
     2221 ggccggcggc gccgctgccg cctccctggg cgagcagggc tacaacgtca aggtcttctt
     2281 ctaccaggac tcgcccgccg ggcgcactcc atcgccgccc agggcggtat caacgccgcg
     2341 aagaactacc gcaacgacgg cgactccacc taccggctct tctacgacac ggtcaagggc
     2401 ggcgactacc gcgcccgcga ggacaacgtc taccgcctgg ccgaggtcag cgcaacatca
     2461 tcgaccagtg cgtggcccag ggcgtccctt cgcccgcgag tacggcggcc tgctggacaa
     2521 ccgctccttc ggtggcgtcc aggtctcccg taccttctac gcccgcggcc agaccggcca
     2581 gcagctcctc atcggcgcct accaggccct ggagcgtcag gtgcacgccg ggacggtcaa
     2641 ggagttccgc cgccacgaga tggtcgagct catcctcgtc gacgggcgcg cccgcggcat
     2701 cgtcacccgc gacatggtct ccggtgagat cgagacccac ctggccgacg ccgtcgtcct
     2761 ggccagcggc gggtacggca acgtgttctt cctgtccacc aacgcgatgg gctgcaacgc
     2821 caccgccatc tggcgcgcgc accgcaaggg cgcctacttc gccaacccct gctacacgca
     2881 gatccacccc acctgcatcc cgcagtccgg agacttccag tccaagctca ccctcatgag
     2941 tgagtcgctg cgcaacgacg gacgcatctg ggtgcctaag cgggccgagg actgcgacaa
     3001 ggacccgcgc gacatccccg aggaggctcg cgactactac ctcgagcgca tctacccggc
     3061 cttcggaaac ctcgtgccgc gtgacatcgc ctcgcgtcag gccaagaaca tgtgcgacga
     3121 gggccgcggc gtgggcccgg ccatcaagga gcgcgacgcc aacggcaacg agcggatgat
     3181 gcgtcgcggc gtctacctgg acttctccga ggccatcggc cgcctgggca aggacgccgt
     3241 ctccgcccgc tacggcaacc tgttcgagat gtaccagcgc atcaccggcg acgaccccta
     3301 cgaggtcccc atgcgcatct acccggccgt gcactacacg atgggcggcc tgtgggtgga
     3361 ctacgacctg gagtccaacg tcccgggcct ctacatcgcc ggtgaggcga acttctccga
     3421 ccacggcgcc caaccgcctg ggcgcctcgg cgctcatgca gggcctggcc gacggctact
     3481 tcgtcctgcc cgacaccatg aacgactacc tggcggacat gctgcgcctg ggcaaggtcg
     3541 acccgaacgc cccggagatc gccgaggcca agcgctccgt cgaggagcgg gtcgcccgcc
     3601 tcatggccct gcgcggaacc cgcagcgtgg acgacttcca catggccctg ggacgcatca
     3661 tgtgggagta ctgcggcatg gagcggcgtg acgccggtct gcgcgacgcc atcaagcaga
     3721 tccgggccct caaggaggag ttctggcgcg acgcccgcat cacgggccag gccgacgagc
     3781 tcaaccaggc cctggagaag gccggccggc tgctggactt cttcgagctg gccgagctca
     3841 tgtgcatcga cgccctgcac cggcgtgagt cctgcggtgg tcacttccgg gcggagtccc
     3901 agacgcccga gggtgaggcc atgcggcacg atgacgagtt cctctacgtc gccgcctggg
     3961 agtggggcgg ggagaaccgt ccgccgatcc tccacaagga ggacctcgtc tacaaggaca
     4021 tcgagctcaa gcagcggagt tacaagtgaa catcaagctc aagatctggc gccagaagaa
     4081 caaggactcg aagggccact ttgaggagta cgccatgagc gggatcgagg agcacatgag
     4141 cttcctcgag gtcctcgacc tgctcaacga gcagctcttc gccgagggca aggagccggt
     4201 ggccttcgac tccgactgcc gcgagggcat ctgcggtcag tgcggtgtgg tcatcaacgg
     4261 gcaggcccac gggccgatcc gctcgaccac ctgccagttg cacatgcgtc acctggcgga
     4321 ggacccctcc ttcaaggacg gctccaccat cacgatcgag ccgtggcgct ccaccggctt
     4381 cccggtgctg cgcgacctca tcgtggaccg ctccgccctg gaccgcatcg tccaggccgg
     4441 cggctacatt tcggtcaaca ccggtggtgc ccccgaggcg cactcggtgc ccgtacagaa
     4501 ggagaaggcc gacgccgcct tcgaggccgc cgcctgcatc ggctgcggcg cctgcgtggc
     4561 cgcctgcccc aacgcctcgg cgatgctgtt cacgggtgcg aagatctcgc acctggggct
     4621 gctgccgcag gggcagcctg agcgcctcgc ccgcgtggtg agcatgctca atcagcacga
     4681 cgccgagggc ttcggcggct gcacgaacat cggtgagtgc gcggccgtgt gccccaagtc
     4741 ggtgcctctc gaggtcatct cgcgcctcaa ccgcgacctg ggccacgccc tgtggaaggg
     4801 ccagcacgcc cactgaccac ctctccaccc tcatccaccg agccgggcac ttttcgcgta
     4861 cccctgcaga aattctgttg ggccacgcga aaagtgcccg gctcggtgtg aggggctagc
     4921 cgacgacggt gaaggtcacc ccggtgaagt ccggaatccg aggcacctgc gggtcggcct
     4981 cgggaacacc gtcgcccacg aggaggatct gggctccggc ccgctgggct gcggtgtagc
     5041 cggaggcggc gtcctccagc accaggcagg aggagatggg cacgtccagg agctcggcgg
     5101 ccttgagata ggcgccggga tcgggctttc cgcgggcgac gtcgtcggct gagacggcaa
     5161 ccgccggaat ggggaccccg gcctcctgca tgcgcactcg catgagctcg atcggggccg
     5221 aggtgaccag ggccaggggg acgccggcgt cgatcagcgc ggtcaccagt gccgcggcgc
     5281 cggggatctc ggccattcgc ccggccgtgc gcacgatctc ctcctgggcg aagcgctcgt
     5341 ggatggcgtc gtgctcctcc gaggccagct ccggcaggaa ccgacggatc gtgtcgatac
     5401 cggtgcgtcc gggggagtag gccatgatct cgtcgaagcg ctcgctcatg ccgtggtcgc
     5461 gggcgaagga gcttcacatg gattccacga ccgccgagga gtccacgagc gtgccgtcca
     5521 tgtcgcacag gatcgcctcg gcccgggcca ggcgcaccgg ttccccggcg ggaccgctcg
     5581 acgacatcag ctggacggcc gggtgaacag tcatggtgcc tcctgagacg gaatcaaggg
     5641 aacgagggaa gaaggagcgg atacggccgt cacagggtac caacgaaaga cgggccgtgg
     5701 ccgtgctatg cccacacccc ggagctgccg cggcggtggg agccgaccag gtgggtatcg
     5761 atgatcccga tcgcctccat gagggcgtgc atcgtcgtcg ggccgacgaa gcggaagccg
     5821 cggcgcttga ggtcgcggga cagggcggcc gactgcggtg actgcgtagg gacgtcctcc
     5881 agcctgcgcg gccggggagt cgactccggc tggtaggacc acaccaggcc cgccaggccg
     5941 ccgtcgacgt cgcccgcctc cctgaggcgc agcgtcgcgc gggcgttgtc gatggtggcc
     6001 aggatcttgg cccggttgcg cacgattccc gtattcccca gcaggcggtc cacctccgcc
     6061 tgccgagccg gccacgatct cggggtcgaa tccggcgaag gcgtcgcgga aggccggtcg
     6121 cttgcgcagg atcgtcgccc aggacagtcc cgactgaaag gcctccaggc tcaaccgctc
     6181 gaagacaccc ccgctcatcg cgcaccggca taccccactc ggtgtcgtag tactcgcgca
     6241 gcagcgggtc ggtggcggcc cagcgcggtc tggccaggcc gtcgtcgccc accaccaggt
     6301 ctgggttgcc gggctcagtc acgggtgcct cctcatgcgt cgtgccgcct gccgcacgcg
     6361 tccgttgccc agcggggaca gtgcccgaag gcgcctggcg tcagcccgtg ccggcaggcg
     6421 ataggctgtg ggcttgtgag cgatcctctc catcctcggc atcgagtcca cctgcgacga
     6481 gaccggcgtg gccctcgtgc gcggggcgcg agctcctcgc cgacgtcacc gccacctcca
     6541 tggaccagta cggcgcgctt cggcgggatc atccccgaga tcgcctcgcg cgcccacctg
     6601 gagtccttcc tgcccaccct cgacgccgcg ctggagaagg ccgacgtccg atctgggcga
     6661 ggtcgacgcc gtcgcgggtg tgcgccggcc ccgggctcat cggttccctg accgtcggaa
     6721 tctccgccgc caagccctgg ccgcgagcct ggcaggccgg tctacggcgt caaccacgtc
     6781 atcggcacct ggcggtcgac gagctggtcg acggccccct gcccgagcgg ttcatcgggc
     6841 tcatcgtctc cggcggtcac tccaacctcc tgagcatccg cgacatcgcc accgacgtcg
     6901 tcgagctcgg cggcaccctc gacgacgccg ccggcgaggc ctccgacaag gtcggtcggc
     6961 tcctgggctg ccctacccgg gtggccccca cgtggaccgg ctctcccagg agggcgaccg
     7021 cagcgccatc cgcttccctc gcggcctggc cgccggcaag gacaaggagc gccaccgcta
     7081 cgacttctcc ttctccggtc tcaagaccgc ggtggcccgc tacgtcgagt ccctggagga
     7141 tgccggccag gaggtgcccg gcgccgacgt gtgcgccgcc ttctccgagg ccgtcaacga
     7201 ctccctgacg gccaaggcgg tccaggcctg cctggacacc ggctgcgaca cgctcgtcgt
     7261 cggaggtgga tactccgcca actcccgcct gcggtccctg gccgccgagc gctgcgaggc
     7321 agccggcatc accctgcgcc tgccgccgct gcgcttctgc accgacaacg gcgcccagat
     7381 cgccgccttg ggctcggcgg ccgtgcgcgc cggcgttgcc cccagcccca tggacttcgc
     7441 cccggactca gggatgccgc tggacgtcag cgtcgttcac tgacagtcat tcactgatgc
     7501 ctgccggcgt cccctgaccc ctgctgtgtc gcgccggcgg ccactccccg gatgatgatc
     7561 tcgatcttgc ggtccaggcc gccgcgctcc agccagctct cgttcggggt cagcgcctcg
     7621 ggcagggacg gcgcccgact ggtggccgcc aggcggctcg cctcctgcag ccccgtggaa
     7681 ccgccgcgct cggaggcggg ggtgtcctcc gccggctcct gcccggtcgg cgcggggagc
     7741 ccggagcggc cgacgggggg agcgcattga cctcgatctg cgcgtgcgtg gagatgacgg
     7801 tgtcgcccac gaagtccagg accaccctgg cctcctcggc ctcaagccct ccgtcgacca
     7861 gcacctgaca cgcctgggag acggggccgg cgaagagctg gtgcgcccac ggcaccccca
     7921 tgatgacgcc ggccaggcct ggtactgctc cagcatcccc cagacggcct cgacgtgcgc
     7981 ccggaccgtc tcgggccagc tcctccccgg acgcgggacc tcgacccggg aggcgatccg
     8041 ctccaggcag gcggccagca ggtcctcgcg cgaggcgatc gtgcggtaca gccccgagtc
     8101 cgccacgccc agccgcttgg ccacccgccg tcagcgtgaa gtccgcgatg ccgatctcga
     8161 gtgccggcgt cgacgacgtc gtcgcgcgag aaaccgggtc tcggtccggt cggtccggcc
     8221 cagtcgcgcc agtgatgcca tggcagcaca gtagtgcgcc gcgacgacgg ttgctcccgc
     8281 ttcagcggtg agaataaggc gggccttatc gaattctgaa atgtattcag aattagagcc
     8341 gacggaagga tgaggctcct catgagcacg cagactcagt cgttgtcgag gacgtcgccg
     8401 caaccttcgg cgagcactca gtccgccgag gcgccgggcg atcagccccc gcagagcaac
     8461 gcccagcgct cgcgcgaggg gcaggccgcc atcgctcgcc tgggcgctcc cgtgtgcacc
     8521 cgcctgagga tcggtcaggc cctcgtcccg ctctccgcgg tcctggcggt ggcgccgtac
     8581 gtcgcactgg tccagctcgg cgacatcctt ctgcgcgcct accgggccgg ggtggggccc
     8641 gacccccagc aggtgccgct ccgccgtcat gatgctcgtg ggacctactc acccggctgc
     8701 tcctgtactt cctggccctg ctcatcaccc acatggccga cctgtccctg cgcgatcggc
     8761 tgcggcgcga catcgtcgac cgcatctccc atgctccgct ggcctggttc accgcctcca
     8821 cctccgggcg catccgcaag gccgtccagg acgacacgac cctggtccac accgtcatcg
     8881 cccacggccc cgtcgagcgt ctcaacgccg tcgtcactcc gttggcgcta ctggtgtgcg
     8941 cccttctgga tcgactggcg cctggcactg atcgcgctgt ccacactcgt cctctacgtg
     9001 ctcacctact cggtgtcgat gcgcggcatg aaggagaaga ccgtggagat ggaccgcaag
     9061 ctcgccgcca tctcctccac catggtcgag ttcgtctccg gcatcggcgt ggtcaaggcc
     9121 ttcggccgcg tcggccgcgc ccactcggcc tacctcactg cggccgacga gttctccgcc
     9181 ttctaccgcg cctgggcgat gcccctggtg actgtcacct gcctgtcctt cacctgggtc
     9241 tcgatcccgg tgctcctcct ggtcaacctc ggtgacgggg cactgctcat ccatgccggc
     9301 gccgtcaccc tgccccaggt cctggccacg accctggtcg ccctgggtcc tgcccgccgt
     9361 gctcatcacc atcgcctcga tctcctggtc ctaccagatg gccggagcgg cggctctgcg
     9421 cctgtgcgag gtcctcgaca cccccgttct gcccgttgcc gaccgtcctg agcggccccg
     9481 cagcgccctt gtcgagatca gccacgtctc cttctcctac ggggacaccc tcgccgtcga
     9541 cgacgcctct ctcgtcctgg agccgggcac cgtcaccgcc tgctgggacc ctccgggtcg
     9601 ggaaagtcga cactggccac cctcatcgcc cgcttcgccg accccgacgc cggagccgtg
     9661 cgcatcggcg gggtggacct gcgggacatg gacgagacga ccctgtactc caccgtctcc
     9721 ttcgtcctcc aggacgccca gctgctcggg accaccgtgc gggagaacat cgcgctcgga
     9781 cgccccgacg ccgacctgga ccaggtgcgg gccgccgccc gggtggcccg catcgatgag
     9841 gagatcatgg cactgccgga cggctacgac accgtcctgg gacaggacac cgccctgtcc
     9901 ggaggccagg agcagcgcat cgccatcgct cgtgccatcc tgctggacac tcccgtcatc
     9961 ctgctcgacg aggccaccgc catggccgat cccgagtccg aggccgagat ccagcaggcg
    10021 ctgagcgccc tggtcaagga acgaacggtg ctggtgatcg cccaccgccc ggctgccgtg
    10081 cgcggcgccg accgcatcgc cgtcatggag cgggggcgca tcgtcgcctc cggcacccat
    10141 gacgacctcg tgaacgagcc ccactaccgg gccctcctgc ggcagactgg tgagctcgac
    10201 ggcgctgccg gcccgattgg cgagagctcc gtgaccgggg cggacgggcc ctccctcgcc
    10261 gacgaaccgg gtggcgaggc ctccggtgct ccgtccccgg actccgtcga gcaggccgtc
    10321 gagcaggttc ctgaccggag ccggtcggtt cccccggtcc cgacgccggc cgccggtgcc
    10381 tccggagccg tacgctccct gctggcccgc ttccgcaggc tcatgctcga ctcctctggc
    10441 ggccagacgc gcacgagtct cgtcctgggc gcggccaacg gcgtcgcatc cgggccgcac
    10501 tgatctcact cctgcccgcc tcggtcgccc tggggaccgg cgcgccccga tggggactgt
    10561 ccgtcggcgg gtggctcctc gtcctcgtcg tgtgcggcgt cgttgccgcc gtcaccgagt
    10621 tccagggaca gcgccgagga atgtccgggc gctcggcttc atgcacgacg tccaccacgc
    10681 cgtcggcgac cggattcgcc cgcctgcccc tgcgctggtt caacgccgac tccgcaggga
    10741 gcctgtcgcg ggccgtcagc caggagatgg tggcccctcg gggagtccgc cgcccacttc
    10801 atgtacatgc tcacctccac caccgccgcc tgcgtcgtcg tctgggccgg ctcctgggcc
    10861 tgggactggc gcctgggcct cctgctgacg gtggccgcgc ccctgttcgc cgaactcgtg
    10921 cgcgccgcac gccgcctgat ggatcacggc aagtcgatct ccgagcccgc cgagcgcgag
    10981 ctggcaaccc gcgttgtcga gatcgcccgc tgtcagggcc ctgcgctcgt gccgggccgc
    11041 caccggctac agccgcctga gggccgcctt cggacgacgg cgtccgtgcc tcacggcgct
    11101 ccctgtagtg ggagaccgcc ggtaacgtcg tcaacggtgc actgagccag gtcgtcgtcg
    11161 tggccatgat cggcctgacc gcctccttcg ccgtctccgg aaccatggag ccgctcgtgg
    11221 ccgtcgccat catcggcatg tgcctgcgct tcaccaccat gctcgacgac atcagcgggg
    11281 ccgtcatggg catggaggag cgccgtcaga tgatgaacca cctcgacgcc gtcatggacg
    11341 ccgagctcat ggccgagccg cagacccgtg ccacgctgtc cgatcctgga gccgtcgagc
    11401 tcgacgacgt cgtcttcggc taccgcgccg accatcccgt cctggccggg gtgtcgatga
    11461 acgtccccgc acgcaccatg tgcgcgatcg tggggccctc cggcagcggt aagacgacca
    11521 tcgcccgcct ggtcgcccgc ttctggacgc cgactccggg accgtgcgcg tgggcggcac
    11581 cgacgtgcgc gacatgccga ccgcacagct catggagcag ctctccatgg tcttccagga
    11641 cgtctacctc ttcgacgaca ccctggacgc caacatccac atcggagacc ctgcggccga
    11701 cgacgatcag gtgcgctgag ccgcagacct cgctggtgtc accgagatcg tcgaccgtct
    11761 gccccacggc tgggacacgc gcgtgggaga gggcgggcgg gccctgtccg gcggtgagcg
    11821 ccagcgcgtc tccatcgccc gcgccctgct caagcgcgcg ccgatcgtcc tgctcgacga
    11881 ggccaccagt gccctggacg cggagaacga ggccaatatc gtggccgcga tgcaggagct
    11941 gcgacgcacc tcgacgctca tcgtcatcgc ccacaagctc gagacgattg ctgcggctga
    12001 ccaggtcatc gtcctcgacg acgccggaca cgtcgcccag cacggacggc acgaggactt
    12061 gtgacggccg acggccccta ccgcagcttc tgggagcagc gcacccgggc ccgcggctgg
    12121 gagctcgtgt caacgagctg agaaccgttg gccgggaaca gatacgagtc cggcccgtgc
    12181 ccgatccgat tcggaccggg cacgggccgg gtcatgcgag gcgctgccga gatgctgtcg
    12241 gcgtgcgggg acgttatccg ttcatggggt ccatggcgtt gatccgctca acgactagct
    12301 ccgcccgggc ctcggtccgc ttacggaaga tcccctgtgc gacggcgccc ggaaggacga
    12361 cctgcttctc atcgagggcg acaacgacct tgcatacggt cattgaccag ctgccgtaca
    12421 tgtgagcggt gctgatccag atgcgacgat gggcctgctg ccagctcagc ttcttcacac
    12481 gcccaattgg cgagtgaagc tcaagtccct cggagctgac gacggtgcgg atgcgtgtta
    12541 cgccgaccgg tactgcgagc agtggagtgc gtggtgtttc tcggacaggg ggagtttttc
    12601 ttcccgtgag tcgataggat ggagaccatg ccagcagcga aatactcgga ggagttcaag
    12661 gcccaggtcg tgcgtgaggt cacccgtgaa ggaccgcacg atcgcctcgg tagcggcctc
    12721 gtacgatccc caggcccaga cggtgggtaa ctgggtcgca aagtacagaa aagatcgtgc
    12781 taccgaccag gaccgcaaga aggcctccga gtcagccgag atcgcgaagc tgagagcgga
    12841 gaagcaggga gctgtgtcag gagaacgagt tcctgaaaaa agctgcggcc ttcttcgtga
    12901 aggaacgacc gtgaccgagc gctacgggct catcaatcgc gaagaaggcc attaccctac
    12961 ctcctcgatg tgccggtggt ccggtgtctc acggtcgggc tgctactcct ggcgcgaccg
    13021 gccccagtgc gccaccgcca tcggaagaga agtgctggcc accatgatca aggacgcttt
    13081 tgccgactcg tgagggcacc tacgggtacc gaaggatcca ggcccacctg gagcggcgtg
    13141 gcgtgagggt ggatggtgcc acggtccgct ccatcatgcg cgacctgggc cttgaggccg
    13201 cgcagccgcg ggcgaaggtc cgcacctacc gtgccggccg cggaccacgg gtgagcgccc
    13261 cgacctggtg gggcgcgact cccgctgccc acgagcctgg gcgtgagtgg tgcggggaca
    13321 ttcccccgca agcgggaggt accccctcct acatcaggcg cgtgggtcgg gttcgtctgt
    13381 cttgctacgg ttctggactg ctgcaccaag aaggtcgtgg ggtatgcgat ggccgagcca
    13441 tgtgcgcacc tcgctggtgt gtgaggccat cgacatggcg gtcaggcgat gcccggccgg
    13501 gaagggtgtg acggtgtgaa tcgccccggg tttgatggag gcggtgatga cacggaagga
    13561 tcactgtcat gggacagagg aagtaccccg atgagctgcg cgagcgggcc acgaggacgg
    13621 gccttggagg cgctggccga cccggcgcgg gccaagggcg cgatccgcag gatcgccgag
    13681 gagctgggag tccaccccga ggctctgcgc tcctgggtca agaaggccca ggtcgatggt
    13741 ggtctaagac cgggaaccac caccgatgaa gcgcagcgga tcaaggagct ggagaaggga
    13801 ggtccgagag ctgcgaagag ccaacgcgat cctgaggagt gcgtcggctt ttttcgcggc
    13861 ggagtgtgag cgcccgtcgc gctgatctgt cagtacatcg aggccaagaa ggaggagctc
    13921 ggggcctggc cgatctgcgc cacgctcagc gaggctggtg tgcagatcgc cccgagtgcc
    13981 tgctacgccc gtcgtagccg tcctccatca gccaggtcgt tgctcgacga ggccctcaag
    14041 gcggagatat ccagggtcca caagaaccag ctactcggtg ctgggggccc gcaagatgca
    14101 cgtgatgcgg ggtcgccctt gaggtcgccg agcgtcacgg agccggtcac gtggcccgct
    14161 gtaccgtcga gcggctcatg ggcgacctgg gtctgcacgg tgtcaggcgc gccaagtcgc
    14221 ccaggacgac ccgctcggca cctccggacc ggtgcccggc cgacctcgtc aaaaggcatt
    14281 tcagcgcgtt caggcccaac gagctgtggg tcgccgacat cacctatgtg cgtacgttct
    14341 cggggtgggt ctacgtcgcc ttcgtcaccg acgtgttctc gcggcggatc gtggggtggc
    14401 agaccaccta ccggccagtg tgcaccgacc tggctctgga cgccctcaag atggccgtct
    14461 ggcagcgaaa acgcaccggg gctgatctct ctggcctggt gcaccacttg cgaccgcggc
    14521 gtgcagtacc ggtccatccg ctacgggcag gccctatcag actgcgaggc agtcgcctct
    14581 gtaggctcta a
//
