LOCUS       c00013_NZ_FNBF..       16530 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_FNBF01000015.1 Eubacterium pyruvativorans strain i6, whole genome
            shotgun sequence.
ACCESSION   NZ_FNBF01000015
VERSION     NZ_FNBF01000015
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 01:35:59
            Original ID  :: NZ_FNBF01000015.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 27794
            Orig. end    :: 44324
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16530
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[37794:40170](-)"
                     /cutoff="2000"
                     /detection_rule="((PFL_proline or cds(PFL-like and
                     Gly_radical)) and Radical_SAM and P5CR_dimer and
                     F420_oxidored)"
                     /neighbourhood="10000"
                     /product="Hydroxy-L-proline2proline"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      complement(10001..12376)
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_proline or cds(PFL-like and
                     Gly_radical)) and Radical_SAM and P5CR_dimer and
                     F420_oxidored)"
                     /neighbourhood="10000"
                     /product="Hydroxy-L-proline2proline"
                     /protocluster_number="1"
     cand_cluster    1..16530
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_proline or cds(PFL-like and
                     Gly_radical)) and Radical_SAM and P5CR_dimer and
                     F420_oxidored)"
                     /kind="single"
                     /product="Hydroxy-L-proline2proline"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16530
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Hydroxy-L-proline2proline"
                     /region_number="1"
                     /rules="((PFL_proline or cds(PFL-like and Gly_radical)) and
                     Radical_SAM and P5CR_dimer and F420_oxidored)"
                     /tool="gutsmash"
     CDS             417..1508
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg13_25"
                     /sec_met_domain="Aminotran_5 (E-value: 3.5e-57, bitscore:
                     185.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKYDRVYNFSAGPSMLPVPVLEKARDELLNYHGTGESVMEMSHR
                     SAEYQEIIDRAEADLRDLLKIPDNYKVLFLQGGGTLQFSMVPMNLLRKSKKADYIITGN
                     WAKKAYEEATKFGDIRIAATSEPDHYSYIPKCGRDDFREDADYVYICYNNTIYGSHFNY
                     IPDTGDIPLVADMSSSFLSEEVDVSKFGLIYAGAQKNVAPAGVTIVIVREDLLGFADEK
                     TPIYLDYATHAKKGSMYNTPPCFTIYMAGLVFQYLKSIGGVKAIHEIDVKKAGKLYDYL
                     DSTDFYRTGIEPEDRSLMNVTFVTGNPELDAKFVAEAKEQGMINLKGHRSVGGIRASIF
                     NAMPPEGVDKLIEFMKQFEAKNR"
     CDS             1568..2998
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S11"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg13_26"
                     /sec_met_domain="Peptidase_S11 (E-value: 1.1e-38, bitscore:
                     124.2, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKGIREFGRKAAREPGRRNITAHQVEEAGKRRRSGFFGRFWIVIL
                     TVVLAAGLLPVPGQGGRVYAQDQPELTAKGAVVYCENTDEIVFAKGKNDKLSPYSITKL
                     MTAMLAVQNAPLDQKVTVSREAASQKDTSMGLKEGEQVTVEQLLYGALILSGNDAAYAL
                     GEAVSGTGKMKDFVAMMNETAKNIECRHTHFDNPSGISDRNNYTTAADFLQIARVAYSN
                     PTIRKIAGTKVYHMGLTNKSGARTMKNTAELINKSGSGVYAAKNGFWSDDDCSTAVAYR
                     KDGLQLFIILLGDTKKEREKDLLALIQYAKKSVQGIVAVKAGTHVGKVHVRHGARTSVD
                     VYTGETGYAYLPKEGSSRLVSTKTDLYSNVKAPLVSGQRVGTYRIYVSGEQVNSVPIVV
                     RENVLPGWLPSYLGISNFATVVILLLLLAVVAVLLWIASIRARNRRRRRLARQRKIERL
                     ARQKMMEEEERNQRGWRF"
     CDS             3000..4868
                     /locus_tag="ctg13_27"
                     /transl_table=11
                     /translation="MFDIQENLKKLPDSPGVYLHKDRLGQVIYVGKAISLRNRVRQYFQ
                     TSYQNSSPKVKAMVGHIAEFEYITCGSEMEALILECNLIKKYMPKYNVLLRDDKTYPYI
                     MITTSEDYPRVVKTRRISRDGNRYFGPFSDAGAVNQIVDLLNQLFSLKRCSMTEFPPNH
                     RPCLNYHIGACRGVCLGHVDKDQYYESIAKISQFLSGKDKPLVDLLTKRMQDASAKMAY
                     EEAARWRDMIQAVKSLKETQRVTMISDQDLDIVHAVKDRDRSFIVLFPVRDGKLSGRET
                     FPIQSDEGDTRGDMVREFLKQYYSQWARVPGEILVDEEPEEKELLEEFLSREGRKVHIN
                     VPKRGSKRALMDLTRRDLVEMTKTLQVRAETHREQEEAVYREMESLMQAGGFHRDPERE
                     GKPYRVESYDISNTNGVDSVGAMVVFSGLERVRKDYRRFRIKTVEGPDDYGSLQEVLYR
                     RFRRALAGDPGFIRLPDMIMMDGGLGQVSAACDVLDAMQLEIPVVGLAKDDSHRTRAVV
                     FRDGREVPLRSRPDLFRYAGTIQEEVHRYAIAYHHKLHGKNAMHSVLDNIEGVGPKRRN
                     ELLYHFKTVDNIRNATVLQLMEVPSIPQHVAENIVAYFQKHKKPVK"
     CDS             4975..5955
                     /locus_tag="ctg13_28"
                     /transl_table=11
                     /translation="MLSGYGNWKIKYVEEDGGILLLRAVTCDRDAVLPAEIGGVPVTGI
                     WNYAMGPKDHTEKEEGTWIELEGAGGDGEKKWSNAGIRSLTLPESVRFIGEYAFHGMYD
                     LEKLELFDVPVTWCAEACQNWFSLHEIIIRSWQGGQGNLAYLCEHFSAELDVRIFWEDG
                     RTARLLFPEYLEVVTENTPARQFVTNTEGFGYPYHHLFRGGQLSFGLYDGEWEYALSHE
                     AEDPEGLLTLAWYRLYWPEGLQDRFREGYQKYVSKNRMKLLDRLIREDAPGQLEKMLKL
                     VPAERAELDRGCETARTLRRTACLAVLMQQIRGLVPAGRKKNFDL"
     CDS             5987..7342
                     /locus_tag="ctg13_29"
                     /transl_table=11
                     /translation="MAYEKGQIGNEILRAVRNELYMNLPYLDVPLCSLGIREDAGATLG
                     MATDGMELVYNERWLKDRYLRSRRWVNRGYLHVILHCILRHIWKARGKDPVLWDIACDA
                     AVEALLAELDYDCLAVGRYPLREKFLRECAGAMRVITAEGVYLHLLRKKGLTEEDKKSL
                     WKTFHVDDHDYWTPRSRKQEQERQEQDERWEKISRQTQQNQGRGMTESGNGKAVIEQLN
                     VELRENVDYRSFLRRFAAPKEVMRADPDSFDYIFYTYGLQLYGNMPLVEPRETREEKRI
                     EDLIIAVDTSMSTNGDLVKAFLSCTYSILHSTETYTRKVNIHIIQCDNRVEADDAIHDL
                     DDLKEYMSHFTLKGGHGTDFRPVFEYADEMVRRGEFRNLRGLIYFTDGMGHYPKKRPAY
                     ETAFVYLGKAPELFPAPPWAIRLELDLPDLYRAAEDDEELEDLIQWEDLPDM"
     CDS             7360..8946
                     /locus_tag="ctg13_30"
                     /transl_table=11
                     /translation="MAMNIKQAKQEIRNTLRAYLSKDDLGNYLIPPKRQRPVLLMGPPG
                     IGKTQIMEQIAEEEGIPLISYTMTHHTRQSVIGLPFIVHQQFQGEDTPVTEYTMSEILA
                     TVYEMMEKTGRQEGILFLDEINCVSETLTPVMLQFLQYKTFGNRKLPDGWLIVTAGNPP
                     EYNKSAREFDVATMDRVKMIEVQEDFSVWKEYAYRNGIHGAIISYLDIKKENFFRIENT
                     VDGMRFITARGWEDLSEMLQAYEKLGIRPDRQMISEYIQLPGIARDFAGYLDLYRKYQE
                     TYHVDEILRGSWKPVTTRSFQTAPFDEKLSVMGLLHARLSDKARETRRKDALAGALHSD
                     LIRFRSGLEEGKDPGDRMEELADSVLRELKNAEEEKRLSREERELLQKEYRILDGYTSD
                     LRNEAAGASSDQAMDLVREWFAGVVEDRGKQVDDTSSSFDHAFGFLEQALGDSQEMVIF
                     VTNVTAGYDTSWFVQNFGCEAYYRHNRELLFDDVEQKIRGEIRDAEAENQEAASARQQE
                     GLQQIAEMLQK"
     CDS             complement(9074..9883)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) P5CR_dimer"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1046:NADP oxidoreductase coenzyme F420-dependent
                     (Score: 67.8; E-value: 3.4e-21)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg13_31"
                     /sec_met_domain="NAD_binding_2 (E-value: 4.7e-07, bitscore:
                     21.3, seeds: 140, tool: rule-based-clusters)"
                     /sec_met_domain="F420_oxidored (E-value: 1.9e-21, bitscore:
                     67.8, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="P5CR_dimer (E-value: 5.7e-41, bitscore:
                     130.4, seeds: 951, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLGFIGCGVMANAMMGGIIKNGLLKPEEIWGADPFEGSRQKTKE
                     QNGIHVTESNLEVIENCDVVFLTIKPQYYADAIASFRDHVREDQMFISIGAGRTLDYIA
                     EQFENKPVKVVRVMPNTPAQVAEGMSAACPNQYVTEEETQTALTILRAFGKAELMPESL
                     FDVVTGVSGSGPAYVCMFIEAMADAAVLGGMQRSQAYTFAEQTVLGTAKMLMETGLHPG
                     VLKDMVSSPAGTTIAAVRKLEEEGLRRAVIEGVNACTEKSIQMQSAK"
     CDS             complement(10001..12376)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Hydroxy-L-proline2proline: PFL-like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Hydroxy-L-proline2proline: Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg13_32"
                     /sec_met_domain="Gly_radical (E-value: 1.6e-36, bitscore:
                     116.4, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL-like (E-value: 1.6e-216, bitscore:
                     712.0, seeds: 123, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADRGMNERIRRLRRISTTTPAHIDLERAKIETDFYRENEGKYST
                     PVMRAMVLKEYFSRKTLYLGDDELIVGEKGKDPQASPTFPEICTHTVEDMKIMDARDLV
                     SFKVTDEDIALQEKEIIPFWKGKSTREKLLARMTDEWKTAYAAGMFTEFMEQRGPGHTC
                     GGDRIWTHGYLDYKQEIQDAIDRLDYMNDPEALDKFEELTAMSIDCDAICILGERYYKL
                     ALEKAAEEKDPQRKKELEQIAANCAVVPAHKPQTYWQALQAYWFTHLAVTTELNPWDAF
                     SPGRLDQHLFPFYEADTEAGILDDEHALELLECLWVKFYNQPAPVKVGVTLKESGTYTD
                     FANINTGGITPEGKNGVNAVSYLILDCMDEMQLVQPNSNVQISKKTPQKFLKRACEISR
                     KGWGQPAFYNTDELVQELMNAGKTVDDARCGGSSGCVETGCWGKEAYILTGYLNIPKIF
                     QLTLYDGYDTCTEQQLGLHTGNAQDFQTFEELWNAFEKQMKYFVDMKIRGNNVIEKIFA
                     EELPAPFLSIVTDDCIQNGKDYNAGGARYNTRYIQGVGIGTVTDCAAAIKYNVFDQKKF
                     TMAELLKAMEADFQGFDDIYSMVHDKSPKYGNDDDYADDIMKEIFDLYHDTITGRPTVC
                     GGTYHIDMLPTTCHVYFGDVILATPNGRKAHKPVSEGISPEKSADVNGPTAVIKSCAKM
                     DHIATGGTLLNQKFTPGVVAGEAGLDNMANLIRSYFAMDGHHIQFNVVDRQTLLDAQAH
                     PEEYQDLIVRVAGYSDYFKNLDKQLQDEIIERTEQSFE"
     CDS             complement(12382..13305)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg13_33"
                     /sec_met_domain="Fer4_2 (E-value: 2.7e-09, bitscore: 28.1,
                     seeds: 214, tool: rule-based-clusters)"
                     /sec_met_domain="Radical_SAM (E-value: 7.1e-25, bitscore:
                     79.5, seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 7e-06, bitscore: 17.7,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDAPVITNIQKYSIHDGDGIRTSVFFKGCPLRCLWCHNPETQVY
                     ERQIQFDPEKCTGCGRCARACPEQAISIDPGTAKACTDTALCQFHGKCEEACVTGARAV
                     LGRQYTVQEVMKEIMKDEMFYEQSGGGVTLSGGEVMTQNMDYIEELVKKLHREMITVYI
                     DTCGQAPYENFHRILPYVHTFLYDLKCMDPETHRKYMGVGNSLILENLKRLSEDGARIY
                     IRIPTVPGVSGTEENMRETIAFLKNNHIHTPQINLLPYHNTGSGKYAKLGRTYGGAELE
                     VPSKEQMEHFAEMFRAAGYSNTKIGG"
     CDS             complement(13509..14099)
                     /locus_tag="ctg13_34"
                     /transl_table=11
                     /translation="MRENRSLKEVIIESAWELFSEKGYDQTTINDIISKAGISKGSFYY
                     YFRSKDTLLNTLSNVLDNKYKQFEMEMSRDMNRFDELIELNYRMHNYIGKKLDYRLLAN
                     LYASQLTKAEDSNLLDRNRYYFRMITRLIDEGQKRGEIVADRPVHEIARIYGLCERALI
                     SDWCMNNGEYDLGEMSHQYMPLLFSTFRGKPEK"
     CDS             14424..14720
                     /locus_tag="ctg13_35"
                     /transl_table=11
                     /translation="MADEKNTLIPEEEEAEVITLEFDDGSKVDCEILGVFDYDDKDYIA
                     LIPDDGSDDVYLYRYQEYDDASFELIDITDDALFNKVAHEFDEIMASQEAEEE"
     CDS             14883..16262
                     /locus_tag="ctg13_36"
                     /transl_table=11
                     /translation="MEKYDIVVCGAGVGGVFMAYELTKVQNNARVLVIDAGGPIEKRVC
                     PISTGKTKQCINCNPCSIMNGYGGAGGLSDGKYNLTTQFGGDLHQYLGEEKTMALMYYV
                     DEVLCGMGGSGAKLYSTANSELKTKCLQHDLHLLDAQVRHLGTDTNVKILGNIYEYVKD
                     RIDIHFYERVADITQEGDGTFRVHTDKETYGAADVVLATGRSGSEWMSEICGKFGIPTK
                     KNRVDIGVRVELPAEVFKHITDQVYESKIVYQTEKYNDLVRTFCMNPYGEVVSENTNGI
                     VTVNGHSYSNPELRTENTNFALLVSNHFTEPFEDSNEYGQAIASLSNMLGGGVLMQRFG
                     DLVKGRRSSARRMEKCFTKPTLHATAGDLSLVIPKRQLDDIIEMIYALDTIAPGTANED
                     TLLYGVEVKFYNSKVEVDSNLMTRVPGLYAIGDGSGVTHSLSQASASGIYVARELAEKY
                     Q"
ORIGIN
        1 attttcgcct gtgccaaccc gacaccggaa atcttcccgg atgaggcgaa ggccgccggc
       61 gcggtggtga tctccaccgg ccgttctgat ttcccgaatc agattaacaa cgtgctggct
      121 ttcccgggca tcttccgggg cgccttcgat gtccgggcga aggacatcaa tgaggagatg
      181 aagatggctg cggcgaaggc gctggcggac ctgatcccgg cggaagaact gaatgcggac
      241 aacatcattc cgaaggcctt cgatccggcg gtgggaccgg cggtggcgaa ggccgtggcg
      301 gaagcggccc ggcagtccgg tgtggcgaga atctaagacg ttaattgttt acagtgatga
      361 agaagcgtgc tatactttcc ataaaaattg ttttttctga cagaggggag taagtcatga
      421 gtaagtatga tcgtgtgtac aatttctctg cggggccgtc catgctgccg gttccggttc
      481 tggagaaagc cagagatgaa ctgctgaact atcacggcac cggagagtcc gtcatggaga
      541 tgagtcaccg atctgcggaa taccaggaaa tcatcgaccg ggcggaggcg gatctcagag
      601 atctgctgaa gattccggac aattacaagg ttctgttcct ccagggcggc ggcacgctgc
      661 agttttccat ggtaccgatg aatctgctcc ggaagtcgaa gaaggcggat tatatcatca
      721 ccggcaactg ggcgaagaag gcctatgagg aggctacgaa gttcggcgat atccggattg
      781 ccgccacttc ggagccggac cattacagct acattccgaa atgcggccgg gacgacttcc
      841 gggaggatgc ggattacgtc tatatatgct ataataatac aatctatggt tcgcatttta
      901 actacatccc ggataccgga gacattccgc tggtggcgga tatgtcctcc agtttcctga
      961 gcgaagaggt tgatgtgtcg aagtttggtc tgatctatgc gggggcccag aagaatgtgg
     1021 cgccggccgg ggtgaccatc gtcatcgtcc gggaggatct gctgggcttc gctgacgaga
     1081 agaccccgat ctatctggac tatgccacac atgcgaagaa ggggagtatg tacaatacgc
     1141 cgccttgctt cacaatctac atggcagggc tggttttcca gtatctgaag tctatcggcg
     1201 gtgtgaaggc catccatgaa atcgatgtga agaaggctgg aaaactctat gactatctgg
     1261 actccacaga cttctaccgg accggcatcg aaccggagga ccgttctctg atgaatgtga
     1321 ccttcgtaac cggtaatccg gaactggatg cgaaattcgt ggccgaagcg aaagaacagg
     1381 gcatgatcaa tctgaaggga caccggagtg tgggcggaat ccgtgccagc atcttcaatg
     1441 cgatgccgcc ggaaggtgta gacaagctga tcgaattcat gaaacagttc gaggcgaaga
     1501 accgctgatc gggctttcct tctccggatc ctgatcggca aggtgcgata gaaggagatc
     1561 tataccggtg aagggaatca gagaatttgg acggaaagcg gcccgggaac cgggccgccg
     1621 gaatataact gcacatcagg tcgaagaagc cgggaagcgg aggcggtccg gcttcttcgg
     1681 ccgtttttgg attgtcatcc tcacagtggt tctggcagcg gggctgctgc cggttccggg
     1741 gcagggcggc cgggtatatg cccaggatca gccggaactg acggcgaagg gggcggtggt
     1801 ctactgcgaa aacacagacg agatcgtatt cgccaagggg aagaatgaca agctttcccc
     1861 ctacagcatc acgaagctga tgacggccat gctggcggtg cagaacgctc cgctggatca
     1921 gaaagtgact gtctcccggg aagcggcttc ccagaaggac accagcatgg gactgaagga
     1981 aggggagcag gtgacggtgg aacagctgct ctatggcgca ttgattcttt ctggaaatga
     2041 cgcggcttac gctctgggag aagcggtgag cggcaccgga aagatgaagg atttcgtggc
     2101 catgatgaat gagacggcga agaacatcga gtgccggcac acccatttcg acaatcccag
     2161 cggcatcagc gaccggaata attacaccac cgcggcggat ttccttcaga tcgcccgggt
     2221 ggcctattcc aaccccacga ttcggaagat cgccggcacg aaggtctacc atatgggact
     2281 caccaacaag tcgggcgccc gcaccatgaa gaacacggcg gaactgatta acaaatccgg
     2341 ttccggggta tatgctgcga agaacgggtt ctggtcagat gatgactgca gcacggcggt
     2401 ggcataccgg aaggacggcc tgcagctgtt catcatcctg ctgggggaca cgaagaagga
     2461 acgggagaag gatctgctgg cacttattca gtatgcgaag aagagtgtgc aggggatcgt
     2521 ggcggtgaaa gcggggaccc atgtggggaa agtccatgtg cgtcacggag ccaggacttc
     2581 cgtggatgtc tacaccgggg aaaccgggta cgcttatctg ccgaaggagg gatcttcccg
     2641 gctggtgagc acgaagacgg acctgtacag taatgtgaag gcacctctgg tcagcggcca
     2701 gcgggtgggc acctaccgga tctacgtcag cggcgaacag gtgaacagtg tgccgatcgt
     2761 ggtgcgggag aatgtgctgc cgggctggct tccgtcctac ctgggcattt ccaatttcgc
     2821 aactgtggtc attctcctcc tgctcctggc ggtggtcgcc gtcctgctct ggattgcttc
     2881 gatccgggcc cggaaccggc ggcggagacg gctggcccgg cagcggaaga tcgagcgtct
     2941 cgcccgtcag aaaatgatgg aagaggagga acggaaccag cggggctggc gattctgata
     3001 tgtttgatat acaggaaaat ctgaagaaac tcccggactc cccgggagtt tatctacata
     3061 aggacagact gggacaggtc atttacgtcg ggaaggctat ctcccttcgc aaccgggtgc
     3121 ggcaatactt tcagacctcc taccagaaca gcagtccgaa agtgaaggcg atggtggggc
     3181 acatcgcaga gtttgaatac atcacctgcg gcagtgagat ggaggccctc attctggagt
     3241 gcaatctgat caagaagtac atgccgaagt acaatgttct gctccgggat gacaagacct
     3301 atccgtacat catgatcacc accagtgaag actacccccg ggtggtgaag acccgccgca
     3361 tcagccggga cggaaaccgc tatttcggtc ccttcagcga tgccggcgcc gtgaatcaga
     3421 ttgtggacct gctgaatcag ctcttttccc tgaagcggtg ctccatgacg gagtttccgc
     3481 caaaccaccg gccttgtctg aactatcata tcggcgcctg ccggggggtc tgcctgggcc
     3541 atgtggacaa agatcaatat tatgaatcga tcgcgaagat cagtcaattt ttgtccggaa
     3601 aggacaagcc tcttgtggac ctgctcacga agcggatgca ggacgcctcg gcgaagatgg
     3661 cgtatgaaga ggccgcccgc tggcgggaca tgattcaggc ggtgaagtct ctgaaagaaa
     3721 cccagcgggt caccatgatc agcgatcagg atctggacat cgtccatgcg gtgaaggacc
     3781 gggaccgctc gttcatcgtg ctgtttccgg tgcgggacgg caagctcagc ggccgggaga
     3841 cattcccgat tcagtcggat gagggggaca cccgggggga tatggtccgg gagtttttga
     3901 aacagtacta cagtcagtgg gcccgggttc ccggggaaat cctggtggac gaggaaccgg
     3961 aggagaagga actgctggaa gaatttctga gccgggaggg ccggaaggtg catatcaatg
     4021 tgccgaagcg gggcagcaag cgggcgctga tggatctgac ccggcgggat ctggtggaaa
     4081 tgacgaagac gcttcaggtg cgggcggaga cccaccggga acaggaagaa gccgtgtacc
     4141 gggaaatgga gagcctgatg caggcaggag gatttcaccg ggatccggaa cgggaaggaa
     4201 agccttaccg ggtggaatcc tacgatattt ccaataccaa cggtgtggat tcggtgggcg
     4261 ccatggtggt gttcagcggc ctggaacggg tccggaagga ttaccgcagg ttcagaatca
     4321 agacggtgga gggcccggac gactacggca gcctgcagga ggtgctgtac cgccggttcc
     4381 gccgggcgct ggccggtgac ccgggcttca tccgtctgcc ggatatgatt atgatggacg
     4441 ggggtctggg gcaggtgagc gccgcctgcg atgtactgga tgccatgcag ctggagattc
     4501 cggtggtggg actggcgaag gacgacagcc acagaacccg ggcggtggtt ttccgggacg
     4561 ggcgggaggt tccgctccgg tcccggccgg acctgttccg ctatgcggga acgattcagg
     4621 aggaagtgca ccgttatgcc atcgcctacc atcataagct gcacgggaag aacgccatgc
     4681 actcggtgct ggataatatc gagggtgtgg gacccaagcg gcggaatgaa ctgctgtatc
     4741 atttcaaaac cgtggataac atacgaaatg cgacggttct ccagctgatg gaggtgccat
     4801 ccatccccca gcatgtggcg gagaatatcg tcgcttattt tcagaaacat aagaagccgg
     4861 tgaaatagcc cgggcagggt gaaggccgtt tggaagaggg cttttgcagg cgtcttgcag
     4921 cagggaagag ctgcagatcc cgcacaggga cgcaccgccg gcacaggaga aaaaatgctt
     4981 tcgggatacg gaaactggaa aatcaaatat gtggaagaag atggagggat tctgctcctc
     5041 cgggccgtga cctgtgaccg ggatgcggtt cttccggcgg agatcggcgg tgtgcctgtg
     5101 acggggatct ggaattacgc catgggaccg aaggatcata ccgaaaagga agaaggaacc
     5161 tggatcgaac tggagggggc cggcggggac ggagaaaaga aatggtccaa cgccggaatc
     5221 cgctctctga ccctgccgga aagtgtaaga ttcatcggtg aatatgcttt tcatggtatg
     5281 tacgatctgg agaaactgga actcttcgat gtgccggtga cctggtgcgc cgaagcctgc
     5341 cagaactggt tctccctgca tgaaataatc atccgcagct ggcagggagg gcagggaaat
     5401 ctggcttatc tctgtgaaca tttcagtgcg gaactggacg tgaggatctt ctgggaggac
     5461 ggacgcaccg cccggcttct gttcccggaa tacctggaag tggtgacgga gaacacaccg
     5521 gcccgtcagt ttgtcaccaa tacggagggg ttcggttatc cgtatcacca tctgttccgc
     5581 ggggggcagc tctccttcgg actgtatgac ggggaatggg aatatgcact gagccacgag
     5641 gcggaagatc cggagggact gctgactctg gcctggtacc ggctgtactg gccggaaggc
     5701 ctgcaggatc ggttccggga gggctatcag aaatacgttt cgaagaaccg gatgaaactt
     5761 ctggaccggc tgatccggga agatgcgccg gggcagctgg aaaaaatgct gaagctggtg
     5821 ccggcggaac gggcagaact ggaccggggc tgtgagacgg cccgcaccct ccggcgcacc
     5881 gcctgcctgg ccgtgctgat gcagcagatc cgggggctgg tgccggcggg ccggaagaag
     5941 aacttcgatt tataggctgc agagagaata ttcaaaggga gaatccatgg catacgagaa
     6001 gggacagatc ggaaacgaaa ttcttcgcgc tgtcagaaat gaactgtata tgaatctgcc
     6061 gtacctggac gtgcccctct gttctctggg gatccgggaa gacgccgggg ccacactggg
     6121 tatggccaca gacggaatgg aactggtgta caacgagcgg tggctgaagg accggtatct
     6181 ccgctcccgc cgttgggtga accgggggta tcttcatgtg atcctgcact gcatcctgcg
     6241 tcacatctgg aaggcccggg ggaaggatcc ggtcctctgg gatattgcct gtgatgcggc
     6301 ggtggaggcg ctgctggcgg aactggacta cgactgtctt gccgtcggac gataccctct
     6361 gcgggaaaaa tttctccggg agtgtgccgg cgccatgcgg gtgatcacgg cagagggggt
     6421 gtacctgcac ctgctgcgga agaaggggct gacggaagag gacaaaaaat ctctctggaa
     6481 gacgttccat gtggatgacc atgattactg gacgccccgt tcccggaagc aggagcagga
     6541 gcggcaggaa caggacgaga gatgggagaa aatcagccgg cagacccagc agaatcaggg
     6601 gcggggcatg acagaatccg gaaacggaaa ggccgtcatc gagcagctca atgtggagct
     6661 ccgggagaac gtggattacc gctctttcct gcgccgtttc gcggcgccga aggaagtgat
     6721 gagggcggac ccggattcct tcgattatat cttctatact tacggtcttc agctctacgg
     6781 gaatatgcct ctggtggagc cccgggaaac gagggaggaa aagcggatcg aagacctgat
     6841 catcgccgtg gacacctcca tgtccaccaa cggggatctg gtcaaggcgt ttctgtcctg
     6901 cacctactcg attctgcaca gcacggagac ctacaccaga aaggtgaata ttcatatcat
     6961 ccagtgcgac aaccgggtgg aggcggatga tgccatccac gatctggatg atctgaagga
     7021 atatatgagc cacttcacgc tgaaaggagg acacggcacg gatttccggc cggtgttcga
     7081 atatgcggac gagatggtgc ggcggggaga attccgcaat ctgcgggggc tgatctattt
     7141 caccgacggc atgggacatt atccgaagaa gcggccggct tacgaaacgg cctttgtgta
     7201 cctgggcaag gcgccggaac tgtttccggc ccctccgtgg gcgatccggc tggaactgga
     7261 tctgccggat ctgtaccggg cggcggaaga tgacgaggaa ctggaagatc tgattcagtg
     7321 ggaagatctt ccggatatgt aacagaagga gcttagaaaa tggcaatgaa tatcaagcag
     7381 gcgaagcagg agatccggaa tacgctcaga gcctatctgt caaaggatga tctgggcaac
     7441 tatctgatcc cgccgaagcg gcagcggccg gtgctgctca tggggccgcc ggggatcggt
     7501 aagacccaga tcatggagca gattgcagag gaggaaggca ttccgctgat ctcttatacc
     7561 atgacccacc ataccaggca aagcgtgatc ggacttccgt tcatcgtcca tcagcagttt
     7621 cagggggagg acaccccggt gacggaatac accatgagtg aaattctggc cacggtgtat
     7681 gagatgatgg agaaaacagg gaggcaggaa ggaatcctgt tcctggacga gatcaactgt
     7741 gtgtcggaga ccctgactcc ggtgatgctg cagttcctgc agtacaagac tttcgggaac
     7801 cggaaactgc cggacggctg gctgattgtc accgcaggca atccgccgga atacaataag
     7861 tccgcccggg aattcgacgt ggccaccatg gaccgggtga agatgattga ggtacaggaa
     7921 gatttcagtg tctggaagga atacgcctac cggaacggaa ttcacggcgc catcatcagc
     7981 tacctggata tcaagaagga gaacttcttc cggattgaga acacggtgga cggcatgcgg
     8041 ttcatcaccg cccggggctg ggaggatctg agtgagatgc tgcaggccta cgagaaactg
     8101 ggaatccgtc cggaccggca gatgatcagc gagtatatcc agcttccggg gatcgcccgg
     8161 gatttcgccg gatacctgga tctgtaccgg aaataccagg agacctacca tgtggatgag
     8221 attctgcggg gaagctggaa gccggtgacg acccgttctt ttcagacggc gcctttcgac
     8281 gaaaagctct cggtcatggg actgctccat gcccgcctgt cagacaaggc gcgggagaca
     8341 cggcggaaag atgccctggc cggtgcgctt cacagtgacc tgatccgctt ccgcagcggt
     8401 ctggaagagg gaaaggatcc gggggaccgg atggaggaac tggcggacag tgtgctccgg
     8461 gaactgaaga atgccgagga agagaagcgg ctgtcccggg aagagcggga gctgctgcag
     8521 aaggaataca ggattctgga tggatacact tccgatctgc ggaatgaggc ggcgggtgca
     8581 tcttctgatc aggccatgga cctggtgagg gagtggttcg ccggagtggt ggaagatcgg
     8641 ggaaaacagg tggatgacac ctcttcctcc ttcgaccatg ctttcggttt cctggagcag
     8701 gccctgggag acagccagga gatggtcatc ttcgtcacca atgtcacggc gggatatgac
     8761 accagctggt tcgttcagaa tttcggctgc gaagcctact accgccataa ccgggagctg
     8821 ctcttcgacg atgtggagca gaaaatccgg ggagagatcc gggatgcgga ggcggaaaac
     8881 caggaagctg cttccgcccg gcagcaggaa gggctgcagc agattgcaga aatgctgcag
     8941 aagtagaatt gaaatccggg gcccgcacga tgtatcatgc gggccccggg aagagaatgt
     9001 ttatgatccc gcagaacggt atgagaccgg actgcgggtg tttttttgtc gtctcatccg
     9061 aaggaaggga agactacttc gcactctgca tctggatgga cttctcggtg caggcgttca
     9121 cgccctcaat cacggcgcgg cgcaggccct cttcttccag cttgcggacc gccgcaatgg
     9181 tggtgccggc cggggaagaa accatgtcct tcaggacgcc cgggtgcagt ccggtttcca
     9241 tcagcatctt ggcagtgccc agaacggtct gctctgcgaa ggtatatgcc tggctccgct
     9301 gcatgccccc cagaaccgca gcgtccgcca tcgcttcaat gaacatgcat acgtaggccg
     9361 gaccgctgcc gctgacaccg gttaccacgt cgaaaagact ttccggcatg agctccgcct
     9421 tgccgaaggc ccgcaggatg gtcagggctg tctgggtttc ctcttctgta acgtactgat
     9481 tcgggcaggc ggcggacatg ccttccgcaa cctgggccgg ggtgttcggc atgacacgga
     9541 cgaccttcac cggcttgttt tcaaactgct ctgcgatata gtccagggta cggccggcgc
     9601 cgatggaaat gaacatctgg tcttctctga cgtgatcccg gaagctggcg atcgcatctg
     9661 catagtactg cggcttgatg gtcaggaaaa caacatcgca gttctcgatc acttccagat
     9721 tactttccgt gacgtggatg ccgttctgtt cctttgtttt ctgacggctg ccttcgaacg
     9781 ggtctgcccc ccagatttct tccggcttca gcagtccgtt cttgatgata ccgcccatca
     9841 ttgcattggc cataacgccg catccgataa atcctaactt catttcaatg ctccttccgt
     9901 tacctttgaa aatagtcgtt ttggaataaa tattagatat gacaaaggac ccgcggacgt
     9961 cccggcatgc cgggcgcccg cgcgccgcct tgtgttggta ttattcgaaa gactgttctg
    10021 ttctttcgat gatctcatcc tgcagctgct tgtccagatt cttgaaatag tcactgtagc
    10081 ctgctacacg gacgatgagg tcctgatatt cttccgggtg ggcctgggca tccagcagtg
    10141 tctggcgatc caccacgttg aactggatat gatgtccgtc catggcgaaa taggaacgaa
    10201 tcagattcgc catgttatcc agtccggctt ctccggccac aacccccggt gtgaatttct
    10261 gattcagcag tgtgccgccg gtggcgatgt gatccatctt tgcacaggac ttgatgacgg
    10321 cggtcgggcc gttcacatcg gcggatttct ccggagagat accttcggac accggcttat
    10381 gggctttccg gccgttcggc gttgccagga tgacgtcgcc gaagtacaca tgacaggtgg
    10441 tcggcagcat atcgatatga taggttccgc cgcagaccgt cggccggccg gtgatggtgt
    10501 catgatacag atcgaagatc tccttcatga tatcatctgc atagtcgtca tcgttgccgt
    10561 acttcgggga cttgtcatgc accatgctgt agatgtcgtc gaatccctgg aagtccgcct
    10621 ccatggcctt cagaagttcc gccatggtga acttcttctg gtcgaatacg ttgtacttga
    10681 tggcggccgc acagtcggta accgtgccga tgcccacacc ctggatgtat ctcgtgttat
    10741 accgggcgcc gcctgcgttg tagtcctttc cgttctgaat acagtcgtcg gtgacgatgg
    10801 aaaggaacgg ggcaggcagt tcttcggcga agatcttctc gatcacattg tttccccgga
    10861 ttttcatgtc cacgaagtac ttcatctgct tctcgaacgc attccagagt tcttcaaaag
    10921 tctggaagtc ctgggcattt ccggtgtgca gacccagctg ctgctctgtg caggtgtcat
    10981 atccgtcata cagagtcagc tggaaaatct tcgggatgtt caggtagcct gtgagaatgt
    11041 aggcttcctt gccccagcat ccggtttcca cacatccgga ggaaccgccg cagcgggcgt
    11101 catccacggt ttttccggcg ttcatcagtt cctgcaccag ctcgtcggtg ttgtagaacg
    11161 ccggctgtcc ccagcctttc cgggaaattt cacaggctct cttcaggaac ttctgcggcg
    11221 tcttcttgga aatctgtacg ttggagttcg gctgcaccag ctgcatttca tccatgcagt
    11281 ccagaatcag gtagctgacc gcattgacgc cgttctttcc ttccggtgtg atgccgccgg
    11341 tgttgatatt ggcgaagtcc gtgtaggttc ccgattcctt cagcgtgaca ccgaccttca
    11401 ccggcgccgg ctggttgtag aacttcaccc acaggcactc caaaagctcc agtgcgtgct
    11461 cgtcgtccag aatacccgct tccgtatccg cttcatagaa tgggaacagg tgctggtcca
    11521 gacggcccgg ggagaaggcg tcccatgggt tcagctcagt ggtaaccgcc aggtgggtga
    11581 accagtatgc ctgcagcgcc tgccagtagg tctgcggctt gtgggccgga accacggcgc
    11641 agttcgccgc aatctgctcc agttccttct ttctctgcgg gtccttctct tctgccgcct
    11701 tttccagcgc cagcttgtag taccgctcgc ccagaatgca gatcgcatcg cagtcaatgg
    11761 acatggcggt gagttcttcg aatttgtcca gcgcctccgg atcgttcata tagtccagtc
    11821 tgtcgatggc atcctgaatt tcctgcttgt agtccagata gccgtgggtc cagatccggt
    11881 cgccgccgca ggtgtgaccc gggccccgct gctccatgaa ctctgtgaac ataccggcag
    11941 cgtatgcggt cttccactcg tctgtcattc tggccagcag cttctcccga gtggacttcc
    12001 ccttccagaa cgggataatc tccttctcct gcagtgcgat gtcctcatcc gtcaccttga
    12061 aggaaaccag atcccgggca tccatgatct tcatatcttc cacagtgtgg gtgcagatct
    12121 ccgggaaggt cggggaagcc tggggatcct ttcccttctc gcccacaatc agttcgtcat
    12181 cacccagata cagggtcttc ctggagaaat actccttcag taccatcgcc cgcataaccg
    12241 gggtggaata ttttccttcg ttttcccgat aaaaatctgt ttcaatcttc gcccgctcca
    12301 ggtcgatgtg tgccggtgtg gtggtgctga tcctgcggag acgccggatt ctttcgttca
    12361 ttcctctgtc agccatttcg attaacctcc gattttcgtg ttgctgtaac ctgccgcccg
    12421 gaacatctct gcgaagtgtt ccatctgctc cttcgacgga acttccagtt ctgctccgcc
    12481 gtaagtgcgg cccagcttcg catacttccc gctgccggtg ttgtggtaag gcagcagatt
    12541 gatctgtggt gtgtgaatgt gattgttctt cagaaaagcg atcgtttccc gcatgttctc
    12601 ttccgtcccg ctgacacccg gtacggtcgg tattctgata tatattctgg cgccgtcctc
    12661 gctgaggcgc ttcagattct ccaggatgag agagttgccc actcccatgt atttccggtg
    12721 ggtttccgga tccatacatt tcaggtcgta caggaaagta tggacataag gcaggatgcg
    12781 gtggaaattc tcatagggcg cctgaccgca ggtgtcgatg tacaccgtga tcatttcccg
    12841 atgaagtttc tttaccagct cctcgatgta gtccatgttc tgggtcatga cttcgccgcc
    12901 gctcagcgtg acgccgccgc cggactgctc gtagaacatc tcgtccttca tgatctcctt
    12961 catgacttcc tgcacggtgt actgtctgcc caggacggca cgggcgccgg tgacgcaggc
    13021 ctcctcgcat tttccgtgga attgacaaag ggcagtgtcc gtacaggctt tcgccgtacc
    13081 cggatcgatg gaaattgcct gctccggaca ggcacgggca cacctgccgc agcccgtgca
    13141 tttctccggg tcgaactgga tctgccgttc gtacacctgg gtctccgggt tatgacacca
    13201 gagacagcga agggggcagc ccttgaaaaa aaccgaggtg cggatcccgt cgccgtcgtg
    13261 gatggaatat ttctgtatgt tcgtaataac tggcgcatca gacatggtat ctgacctcct
    13321 gcattggtgt gttggcggag tcgtatcagg tttagaccgt agtctaaaat cttcaccctt
    13381 attctactat acgcccggag gagatgcaat tcatttgtca aaaaataatc gaattgctgc
    13441 atagaaaata acaatgcggc gggatgaccc gccgcagatg attttcaggg tatttcgttg
    13501 taaaaaatct atttctccgg ctttccccgg aacgtgctga aaaggagggg catgtactgg
    13561 tgactcatct ctcccagatc gtattccccg ttgttcatgc accagtcgga gatcagcgcc
    13621 cgttcgcaga gtccgtagat acgggcgatc tcgtggaccg gccggtcagc gacaatttcg
    13681 ccccgtttct ggccctcgtc gatcagccgg gtgatcatac ggaaatagta gcggttccgg
    13741 tccagcagat tgctgtcttc cgctttcgtg agctgggagg cgtagaggtt ggccagaagg
    13801 cggtagtcca gcttctttcc gatatagttg tgcatccggt aattcagttc aatcagctca
    13861 tcgaaccggt tcatatcccg ggacatttcc atttcgaact gcttatactt gttatccagc
    13921 acattggaga gggtgttcag cagggtgtcc ttgctgcgga agtagtagta gaaggaaccc
    13981 ttcgaaatcc ccgctttcga aataatatcg ttaatggtgg tctggtcata tcctttctcg
    14041 gagaacagtt cccaggccga ttcaatgatc acttctttca ggcttctgtt ttctctcatc
    14101 attctcacgc tttctttctg tatcgtaacg cagtgccgga gctgcaggca ccggcactcc
    14161 tttcacatca gttatcacac atatgtaatg atagtcgata aaaggtcgaa tgtaaagaaa
    14221 agtaagacac ttcggcaggc tccggaggga agaaaatcaa cggctgtgat gttgcgtatt
    14281 gaaaggattg atgttatatt aagttgtaat tgtgattggg cgtacagccc tgtttcattg
    14341 caggatgcgg atcccggccc cggtgcgggg cggcggcggg attcctgccg gcacgccgca
    14401 gtttgcggag aatggagaag gaaatggcag acgagaagaa cacactgatt ccggaagagg
    14461 aagaggcgga agtcatcaca ctggagttcg acgacggttc caaggtggat tgtgagatcc
    14521 tgggtgtttt cgattatgat gacaaggatt atattgcgct gattccggat gatggaagcg
    14581 atgatgttta cctgtatcgt tatcaggagt atgatgacgc atcgttcgag ctgatcgaca
    14641 tcacagatga tgcactgttt aacaaggtgg cccatgaatt cgacgagatc atggccagcc
    14701 aggaagcgga agaggagtag atccgattcc gaaacattcc ggagttttcg caatgcaccg
    14761 accggctttc gccgggggtg catttttcat ggggcggtcc cggaaatgcc gccggcgaac
    14821 ggcagcagat cgttttttgt ccccggatag agagggtccg ggcagaaagg aaaaggaatc
    14881 acatggagaa atatgatatc gtagtgtgcg gcgccggcgt gggcggcgtg ttcatggcgt
    14941 atgagctgac caaggtgcag aacaatgccc gggttttggt aattgatgcc ggaggcccga
    15001 ttgagaagcg ggtgtgcccg atcagcaccg ggaagacgaa gcagtgcatc aactgcaatc
    15061 cctgcagtat catgaacgga tacgggggcg caggcggact gtcagacggg aaatataatc
    15121 tgacaaccca gttcggcgga gatctccatc agtatctggg cgaggagaag accatggcgc
    15181 tgatgtatta tgtggacgag gtgctttgcg gaatgggagg cagcggcgcc aaactatatt
    15241 ccaccgccaa ctcggagctg aagacgaagt gtctgcagca tgacctgcat ctgctggatg
    15301 cccaggtccg gcatctggga acggacacca atgtgaagat cctgggcaac atctatgagt
    15361 atgtgaagga ccggatcgac attcattttt atgaacgggt ggctgacatc acccaggaag
    15421 gggacggcac gttccgggtg cacacggaca aggaaaccta cggggcagcc gacgtggttc
    15481 tggccaccgg ccgctcggga tcggagtgga tgtcggaaat ctgcggcaag ttcggtattc
    15541 cgacgaagaa gaaccgggtg gacatcggtg tccgggtgga gctgccggcg gaggtgttca
    15601 agcatatcac cgaccaggtg tacgagagta agatcgttta tcagacagag aaatataacg
    15661 atctggtccg gactttctgc atgaatccgt acggcgaggt ggtttccgaa aacaccaacg
    15721 gcatcgtcac ggtgaacggc cacagctatt ccaatccgga actccggaca gagaacacga
    15781 actttgcgct gctggtgtcc aaccacttca cggagccctt cgaggattcc aacgagtacg
    15841 gtcaggccat tgcgagtctg tccaacatgc tgggaggcgg cgtgctgatg cagcgcttcg
    15901 gggatctggt caaagggaga aggagcagcg cccgccgcat ggagaagtgc ttcacgaagc
    15961 cgacccttca cgctacggca ggggatctga gcctggtgat tccgaagcgg cagctggatg
    16021 atatcatcga aatgatctat gcgctggata ccattgcgcc gggcacggcc aatgaggata
    16081 ctcttctcta cggtgtggaa gtgaaattct ataattccaa ggtggaagtg gattcaaatc
    16141 tgatgacccg ggtgccgggg ctctatgcca tcggtgacgg ttccggggtg acccactccc
    16201 tgtcccaggc ttcggcgtcc ggaatctatg tggcccggga gctggcggag aaatatcagt
    16261 agggagtgca gccgggcgca tagacgtgcc cggtgggagt gtacgaaaaa gaatacggtg
    16321 ggggctgcag attttccttg caatctccac cggttcccct tatactaatg atgttgctca
    16381 cgagagcagc gaaaatcaga tatgcggttg tggcggaatt ggcagacgcg cacggttcag
    16441 gtccgtgtga tgcgagtcat gagggttcga atccctccaa ccgcaccaag gatgagccgg
    16501 taattgacag ttgtcgatta ccggtttttt
//
